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    Association of warfarin with congestive heart failure and peripheral artery occlusive disease in hemodialysis patients with atrial fibrillation.
    J Chin Med Assoc 2017 Feb 14. Epub 2017 Feb 14.
    Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Institutes of Physiology and Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROC. Electronic address:
    Background: The effect of warfarin on the risk of cardiovascular (CV) disease is unknown among chronic hemodialysis patients with atrial fibrillation (HD-AF).

    Methods: Population-based propensity score and prescription time-distribution matched cohort study including 6719 HD-AF patients with CHA2DS2-VASc score ≥ 2 were divided into warfarin users and nonusers and followed-up for CV events and death.

    Results: Warfarin treatment in HD-AF patients with AF preceding HD was associated with higher risks of developing congestive heart failure [hazard ratio (HR)=1. Read More

    Motor phenotype is not associated with vascular dysfunction in symptomatic Huntington's disease transgenic R6/2 (160 CAG) mice.
    Sci Rep 2017 Feb 17;7:42797. Epub 2017 Feb 17.
    IRCCS Neuromed, Pozzilli (Italy).
    Whereas Huntington's disease (HD) is unequivocally a neurological disorder, a critical mass of emerging studies highlights the occurrence of peripheral pathology like cardiovascular defects in both animal models and humans. The overt impairment in cardiac function is normally expected to be associated with peripheral vascular dysfunction, however whether this assumption is reasonable or not in HD is still unknown. In this study we functionally characterized the vascular system in R6/2 mouse model (line 160 CAG), which recapitulates several features of human pathology including cardiac disease. Read More

    Marrow-isolated adult multilineage inducible cells embedded within a biologically-inspired construct promote recovery in a mouse model of peripheral vascular disease.
    Biomed Mater 2017 Feb 17;12(1):015024. Epub 2017 Feb 17.
    Department of Orthopaedics, University of Miami Miller School of Medicine, FL, United States of America. Geriatric Research, Education, and Clinical Center and Research Service, Bruce W. Carter VAMC, Miami, FL, United States of America.
    Peripheral vascular disease is one of the major vascular complications in individuals suffering from diabetes and in the elderly that is associated with significant burden in terms of morbidity and mortality. Stem cell therapy is being tested as an attractive alternative to traditional surgery to prevent and treat this disorder. The goal of this study was to enhance the protective and reparative potential of marrow-isolated adult multilineage inducible (MIAMI) cells by incorporating them within a bio-inspired construct (BIC) made of two layers of gelatin B electrospun nanofibers. Read More

    A Phase II Randomized Trial (GO27827) of First-Line FOLFOX Plus Bevacizumab with or Without the MET Inhibitor Onartuzumab in Patients with Metastatic Colorectal Cancer.
    Oncologist 2017 Feb 16. Epub 2017 Feb 16.
    Rocky Mountain Cancer Center, Denver, Colorado, USA.
    Background: Dysregulated hepatocyte growth factor/mesenchymal-epithelial transition (MET) signaling is associated with poor prognosis and resistance to vascular endothelial growth factor inhibition in metastatic colorectal cancer (mCRC). We report outcomes from a double-blind, multicenter phase II trial of the MET inhibitor onartuzumab in combination with mFOLFOX-6 and bevacizumab for mCRC (GO27827; NCT01418222).

    Materials And Methods: Patients were randomized 1:1 to receive onartuzumab (10 mg/kg intravenously [IV]) or placebo plus mFOLFOX-6 and bevacizumab (5 mg/kg IV). Read More

    Genetic variants rs1994016 and rs3825807 in ADAMTS7 affect its mRNA expression in atherosclerotic occlusive peripheral arterial disease.
    J Clin Lab Anal 2017 Feb 15. Epub 2017 Feb 15.
    Department of Medical Biology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
    Aim: Peripheral artery disease (PAD) is a vascular disease affecting peripheral circulation. Recently, genome-wide association studies revealed a relationship between single nucleotide polymorphisms (SNPs) in ADAMTS7 (a disintegrin and metalloprotease with thrombospondin motif 7) and atherosclerosis. In this study, we aimed to determine ADAMTS7 expression in peripheral blood mononuclear cells (PBMCs) and the frequency of ADAMTS7 rs1994016 and rs3825807 polymorphisms in a sample of Turkish patients with PAD, and to evaluate the association of matrix metalloproteinase (MMP) levels with PAD development. Read More

    Explaining Racial Disparities in Amputation Rates for the Treatment of Peripheral Artery Disease (PAD) Using Decomposition Methods.
    J Racial Ethn Health Disparities 2017 Feb 15. Epub 2017 Feb 15.
    CTI Clinical Trials and Consulting Services, Inc., 1775 Lexington Avenue, Suite 200, Cincinnati, OH, 45212, USA.
    Introduction: While studies have documented racial and ethnic disparities in amputation rates for patients with peripheral artery disease (PAD), the importance of specific factors has not been quantified. This research seeks to provide such evidence and to quantify how much of the difference reflects observable versus unexplained factors.

    Methods: This study used the nationally representative HCUP inpatient database from 2006 to 2013 for patients with a primary diagnosis of PAD who were either Caucasian, African-American, or Hispanic. Read More

    A comparative study of the risk profile of hemodialysis patients in a for profit network and in two regional registries of the Italian Society of Nephrology.
    J Nephrol 2017 Feb 16. Epub 2017 Feb 16.
    Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension, Azienda Ospedaliera Bianchi Melacrino Morelli, CNR-IFC, Reggio Calabria, Italy.
    In 2013, the Italian Society of Nephrology joined forces with Nephrocare-Italy to create a clinical research cohort of patients on file in the data-rich clinical management system (EUCLID) of this organization for the performance of observational studies in the hemodialysis (HD) population. To see whether patients in EUCLID are representative of the HD population in Italy, we set out to compare the whole EUCLID population with patients included in the regional HD registries in Emilia-Romagna (Northern Italy) and in Calabria (Southern Italy), the sole regions in Italy which have systematically collected an enlarged clinical data set allowing comparison with the data-rich EUCLID system. An analysis of prevalent and incident patients in 2010 and 2011 showed that EUCLID patients had a lower prevalence of coronary heart disease, peripheral vascular disease, heart failure, valvular heart disease, liver disease, peptic ulcer and other comorbidities and risk factors and a higher fractional urea clearance (Kt/V) than those in the Emilia Romagna and Calabria registries. Read More

    Unusual Presentation of Type 1 Idiopathic Macular Telangiectasia.
    Case Rep Ophthalmol Med 2017 19;2017:5395069. Epub 2017 Jan 19.
    Department of Ophthalmology, Croix-Rousse University Hospital, Hospices Civils de Lyon, University of Lyon I, 69004 Lyon, France; CNRS UMR 5510 Mateis, 69621 Villeurbanne, France.
    Purpose. To report unusual presentation of type 1A idiopathic macular telangiectasia (IMT). Methods. Read More

    Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates.
    Cell Rep 2017 Feb;18(7):1761-1773
    Department of Experimental Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands. Electronic address:
    Here, we characterize a subset of ILC3s that express Neuropilin1 (NRP1) and are present in lymphoid tissues, but not in the peripheral blood or skin. NRP1(+) group 3 innate lymphoid cells (ILC3s) display in vitro lymphoid tissue inducer (LTi) activity. In agreement with this, NRP1(+) ILC3s are mainly located in proximity to high endothelial venules (HEVs) and express cell surface molecules involved in lymphocyte migration in secondary lymphoid tissues via HEVs. Read More

    Clearance of cerebral Aβ in Alzheimer's disease: reassessing the role of microglia and monocytes.
    Cell Mol Life Sci 2017 Feb 14. Epub 2017 Feb 14.
    Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, 127 S. San Vicente, AHSP A8115, Los Angeles, CA, 90048, USA.
    Deficiency in cerebral amyloid β-protein (Aβ) clearance is implicated in the pathogenesis of the common late-onset forms of Alzheimer's disease (AD). Accumulation of misfolded Aβ in the brain is believed to be a net result of imbalance between its production and removal. This in turn may trigger neuroinflammation, progressive synaptic loss, and ultimately cognitive decline. Read More

    A Novel Application of Double-Paddle Peroneal Chimeric Flap as External Sentinel Monitor in Hypopharyngeal Reconstruction.
    Ann Plast Surg 2017 Feb 14. Epub 2017 Feb 14.
    From the *Division of Plastic and Reconstructive Surgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung; †School of Medicine, National Yang-Ming University; ‡The School of Medicine of National Defense Medical Center, Taipei; and §Department of Otolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China.
    Objectives: Monitoring the viability of buried free flaps in hypopharyngeal reconstruction is difficult. Various methods have been proposed to monitor these buried flaps, but limitations remain.

    Method: We present a method of using double-paddle chimeric peroneal flaps that permanently externalizes a flap skin paddle as a monitoring paddle in hypopharyngeal reconstructions. Read More

    Vitamin K Antagonist Therapy Is a Risk Factor for Ulcer Development and Death Among Dialyzed Patients.
    Ther Apher Dial 2017 Feb 14. Epub 2017 Feb 14.
    Nephrology and Dialysis Unit, University Hospital "Maggiore della Carità", Novara, Italy.
    Peripheral artery disease is a common complication among dialyzed patients. Since Vitamin K antagonists promote metastatic calcifications and these are the main determinants of vascular damage, we investigated their role in the development of lower limb ulcers in dialyzed patients. We retrospectively enrolled 316 dialyzed patients, aged 68 ± 15 years, 65% male, 32% diabetic, 43% with ischemic heart disease and followed them for 36 ± 25 months. Read More

    Eating the Dead to Keep Atherosclerosis at Bay.
    Front Cardiovasc Med 2017 30;4. Epub 2017 Jan 30.
    Karp Family Research Laboratories, Vascular Biology Program, Harvard Medical School, Boston Children's Hospital , Boston, MA , USA.
    Atherosclerosis is the primary cause of coronary heart disease (CHD), ischemic stroke, and peripheral arterial disease. Despite effective lipid-lowering therapies and prevention programs, atherosclerosis is still the leading cause of mortality in the United States. Moreover, the prevalence of CHD in developing countries worldwide is rapidly increasing at a rate expected to overtake those of cancer and diabetes. Read More

    Safety and Effectiveness of Bone Marrow Cell Concentrate in the Treatment of Chronic Critical Limb Ischemia Utilizing a Rapid Point-of-Care System.
    Stem Cells Int 2017 17;2017:4137626. Epub 2017 Jan 17.
    Fortis Escorts Heart Institute and Research Centre, New Delhi, India.
    Critical limb ischemia (CLI) is the end stage of lower extremity peripheral vascular disease (PVD) in which severe obstruction of blood flow results in ischemic rest pain, ulcers and/or gangrene, and a significant risk of limb loss. This open-label, single-arm feasibility study evaluated the safety and therapeutic effectiveness of autologous bone marrow cell (aBMC) concentrate in revascularization of CLI patients utilizing a rapid point-of-care device. Seventeen (17) no-option CLI patients with ischemic rest pain were enrolled in the study. Read More

    Feasibility and pilot efficacy of a brief smoking cessation intervention delivered by vascular surgeons in the Vascular Physician Offer and Report (VAPOR) Trial.
    J Vasc Surg 2017 Feb 9. Epub 2017 Feb 9.
    Department of Surgery, Boston Medical Center, Boston, Mass.
    Background: This study determined the feasibility and potential efficacy of an evidence-based standardized smoking cessation intervention delivered by vascular surgeons to smokers with peripheral arterial disease.

    Methods: We performed a cluster-randomized trial of current adult smokers referred to eight vascular surgery practices from September 1, 2014, to July 31, 2015. A three-component smoking cessation intervention (physician advice, nicotine replacement therapy, and telephone-based quitline referral) was compared with usual care. Read More

    Perioperative outcomes of infrainguinal bypass surgery in patients with and without prior revascularization.
    J Vasc Surg 2017 Feb 9. Epub 2017 Feb 9.
    Division of Vascular and Endovascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass. Electronic address:
    Objective: Although an increasing number of patients with peripheral arterial disease undergo multiple revascularization procedures, the effect of prior interventions on outcomes remains unclear. The purpose of this study was to evaluate perioperative outcomes of bypass surgery in patients with and those without prior ipsilateral treatment.

    Methods: Patients undergoing nonemergent infrainguinal bypass between 2011 and 2014 were identified in the National Surgical Quality Improvement Program Targeted Vascular module. Read More

    Efficacy and Safety of Alprostadil in Patients with Peripheral Arterial Occlusive Disease Fontaine Stage IV: Results of a Placebo Controlled Randomised Multicentre Trial (ESPECIAL).
    Eur J Vasc Endovasc Surg 2017 Feb 8. Epub 2017 Feb 8.
    UCB Pharma, Brussels, Belgium.
    Objectives: The aim was to assess the efficacy and safety of alprostadil in patients with peripheral arterial occlusive disease (PAOD) Fontaine Stage IV.

    Methods: This was a multinational, prospective, randomised, double blind, placebo controlled, parallel group trial. Patients with Stage IV PAOD were equally randomised to either 4 weeks of alprostadil treatment twice daily or to placebo treatment twice daily. Read More

    Better survival for African and Hispanic/Latino Americans after infrainguinal revascularization in the Society for Vascular Surgery Vascular Quality Initiative.
    J Vasc Surg 2017 Feb 8. Epub 2017 Feb 8.
    The Department of Surgery, George Washington University, Washington, D.C.
    Objective: Inferior survival outcomes have historically been reported for African Americans with cardiovascular disease, and poorer outcomes have been presumed for peripheral arterial disease (PAD) as well. The current study evaluates the effect of race and ethnicity on survival of patients undergoing open or endovascular interventions for lower extremity PAD.

    Methods: Data of patients from the Society for Vascular Surgery Vascular Quality Initiative database were obtained for patients undergoing open infrainguinal (INFRA) or suprainguinal (SUPRA) bypass, peripheral vascular intervention (PVI), and amputation (AMP). Read More

    What are the decision-making preferences of patients in vascular surgery? A mixed-methods study.
    BMJ Open 2017 Feb 10;7(2):e013272. Epub 2017 Feb 10.
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
    Objectives: Shared decision-making (SDM) has been advocated as the preferred method of choosing a suitable treatment option. However, patient involvement in treatment decision-making is not yet common practice in the field of vascular surgery. The aim of this mixed-methods study was to explore patients' decision-making preferences and to investigate which facilitators and barriers patients perceive as important for the application of SDM in vascular surgery. Read More

    Differential leucocyte RNA expression in the coronary arteries compared to systemic circulation discriminates between patients with and those without coronary artery disease.
    Clin Investig Arterioscler 2017 Feb 7. Epub 2017 Feb 7.
    Department of Internal Medicine, Centre for Diabetes and Vascular Medicine, St Franciscus Gasthuis, Rotterdam, The Netherlands.
    Aims: To test the hypothesis that the pattern of gene expression in circulating leukocytes may differ between vascular compartments, depending on the presence or absence of atherosclerosis, we evaluated the regional vascular differences in patterns of inflammatory cell activation.

    Methods: Patients (n=8) with angiographically-established coronary artery disease (CAD+) and 8 without (CAD-) had blood samples taken from a peripheral vein as well as from left and right coronary arteries. Samples were pooled resulting in 4 CAD+ samples versus 4 CAD- samples and hybridised to a Whole Human Genome Microarray 4×44K. Read More

    Validity of Peripheral Arterial Disease Diagnoses in the Danish National Patient Registry.
    Eur J Vasc Endovasc Surg 2017 Feb 7. Epub 2017 Feb 7.
    Faculty of Medicine, Aalborg University, Aalborg, Denmark.
    Objectives/background: The objective was to validate the diagnoses of peripheral arterial disease (PAD) in the legs, obtained from national registers in Denmark.

    Methods: In total, 1435 registered cases of PAD were identified in the Danish National Patient Registry among 57,053 middle aged participants from the Danish Diet, Cancer and Health cohort study. Validation was performed by reviewing all medical records using pre-specified criteria for a diagnosis of PAD. Read More

    [Indications for Retinal Laser Therapy Revisited].
    Klin Monbl Augenheilkd 2017 Feb 10. Epub 2017 Feb 10.
    Zentrum für Augenheilkunde, Universität zu Köln.
    Background Laser therapy is an important treatment option in retinal diseases, especially in cases of vascular involvement. Most approaches are based on coagulation of retinal structures. As there is increasing use of agents targetting vascular endothelial growth factor in the treatment of macular diseases, indications for the use of laser treatment need to be reviewed carefully, especially with respect to their significance in first line therapy. Read More

    Automated image analysis of intra-tumoral and peripheral endocrine organ vascular bed regression using 'Fibrelength' as a novel structural biomarker.
    J Appl Toxicol 2017 Feb 10. Epub 2017 Feb 10.
    AstraZeneca PLC, Oncology iMED, Alderley Edge, Cheshire, UK.
    The study of vascular modulation has received a great deal of attention in recent years as knowledge has increased around the role of angiogenesis within disease contexts such as cancer. Despite rapidly expanding insights into the molecular processes involved and the concomitant generation of a number of anticancer vascular modulating chemotherapeutics, techniques used in the measurement of structural vascular change have advanced more modestly, particularly with regard to the preclinical quantification of off-target vascular regression within systemic, notably endocrine, blood vessels. Such changes translate into a number of major clinical side effects and there remains a need for improved preclinical screening and analysis. Read More

    Associations between polymorphisms of the ADIPOQ gene and hypertension risk: a systematic and meta-analysis.
    Sci Rep 2017 Feb 9;7:41683. Epub 2017 Feb 9.
    Department of Vascular Disease and Hypertension, Peripheral Vascular, 1st Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, People's Republic of China.
    ADIPOQ gene polymorphisms have been indicated to be associated with hypertension; however, published studies have reported inconsistent results. Eligible studies were retrieved by searching the PubMed, Embase and China National Knowledge Infrastructure databases. The case group consisted of patients with hypertension, and the control group consisted of subjects with normal blood pressure. Read More

    Risk Factors for 30-Day Hospital Re-Admission with an Infectious Complication after Lower-Extremity Vascular Procedures.
    Surg Infect (Larchmt) 2017 Feb 8. Epub 2017 Feb 8.
    1 Division of Vascular Surgery, University of Missouri School of Medicine , Columbia, Missouri.
    Background: Lowering the 30-d re-admission rate after vascular surgery offers the potential to improve healthcare quality. This study evaluated re-admission associated with infections after open and endovascular lower extremity (LE) procedures for peripheral artery disease (PAD).

    Methods: Patients admitted for elective LE procedures for PAD were selected from the Cerner Health Facts(®) database. Read More

    Automated oscillometric blood pressure and pulse-wave acquisition for evaluation of vascular stiffness in atherosclerosis.
    Clin Res Cardiol 2017 Feb 6. Epub 2017 Feb 6.
    Clinic of Diagnostic and Interventional Radiology, Saarland University Medical Center, Kirrberger Straße, Geb. 50.1, 66421, Homburg/saar, Germany.
    Objective: Evaluation of diagnostic accuracy of an oscillometry-based device (VascAssist) combining fully automated ankle-brachial index (ABI) and pulse-wave velocity (PWV) assessment for detection of peripheral arterial disease (PAD).

    Subjects And Methods: 110 consecutive subjects including symptomatic PAD patients (n = 41) and healthy PAD-free participants (n = 69) were recruited. All subjects underwent standard manual Doppler-based ABI (sABI) and oscillometry-based automated ABI (aABI) measurements (VascAssist). Read More

    Evolution of patency rates of self-expandable bare metal stents for endovascular treatment of femoro-popliteal arterial occlusive disease: Does stent design matter?
    Eur Radiol 2017 Feb 6. Epub 2017 Feb 6.
    Institute for Clinical Radiology, Hospitals of the Ludwig-Maximilians-University of Munich, Nussbaumstr. 20, 80336, Munich, Germany.
    Objective: To analyse the patency rates of femoro-popliteal stenting with different self-expandable Nitinol stent-designs.

    Methods: Two hundred and twenty-two patients (142 (64%) male; age 72.4 ± 11. Read More

    Associations between chronic comorbidity and exacerbation risk in primary care patients with COPD.
    Respir Res 2017 Feb 6;18(1):31. Epub 2017 Feb 6.
    Department of Primary and Community Care, Radboud University Medical Center, 117-ELG, Geert Grooteplein Noord 21, Nijmegen, 6525 EZ, The Netherlands.
    Background: COPD often coexists with chronic conditions that may influence disease prognosis. We investigated associations between chronic (co)morbidities and exacerbations in primary care COPD patients.

    Method: Retrospective cohort study based on 2012-2013 electronic health records from 179 Dutch general practices. Read More

    [Ischemic origin of diabetic foot disease. Epidemiology, difficulties of diagnosis, options for prevention and revascularization].
    Orv Hetil 2017 Feb;158(6):203-211
    Angiológia, Szent Imre Egyetemi Oktatókórház Budapest, Tétényi út 12-16., 1115.
    "Diabetic foot" as definition covers a multifactorial clinical condition. According to the recent epidemiological data, the role of lower limb ischemia is getting more influential over other pathological causes, like neuropathy, infections and bone or soft tissue deformity. In diabetes, vascular disease leads to increased risk for leg ulcers and minor or major amputations. Read More

    Prevalence of difficult venous access and associated risk factors in highly complex hospitalized patients.
    J Clin Nurs 2017 Feb 6. Epub 2017 Feb 6.
    Bioaraba Research Institute, OSI Araba University Hospital, Jose Achótegui, 01009, Vitoria-Gasteiz, Spain.
    Aims And Objectives: To estimate the prevalence of difficult venous access in complex patients with multimorbidity and to identify associated risk factors.

    Background: In highly complex patients, factors like ageing, the need for frequent use of irritant medication and multiple venous catheterisations to complete treatment could contribute to exhaustion of venous access.

    Design: A cross-sectional study was conducted. Read More

    Thrombolysis in peripheral artery disease.
    Ther Adv Cardiovasc Dis 2017 Feb 1:1753944716687517. Epub 2017 Feb 1.
    Department of Vascular Surgery, KAT General Hospital, Athens, Greece.
    Peripheral artery disease (PAD) has been associated with severe morbidity and mortality worldwide, affecting the quality of life for millions of patients. Acute thrombosis has been identified as a major complication of PAD, with proper management including both open as well as endovascular techniques. Thrombolysis has emerged as a reasonable option in the last decades to treat such patients although data produced by randomized trials have been limited. Read More

    Endovascular management of para-prosthetic aortocaval fistula: case report and systematic review of the literature.
    Ann Vasc Surg 2017 Feb 2. Epub 2017 Feb 2.
    Unit of Vascular Surgery, Department of Surgical Sciences, University of Parma, Ospedale Maggiore, Parma, Italy.
    The aim of this article is to report a case of asymptomatic para-anastomotic aortocaval fistula (ACF) treated by endovascular aortic repair, and to review data of the literature on arteriovenous fistulae (AVF) secondary to abdominal aortic surgery. A 78-year-old male complained of worsening pain in the right lower limb since 2 months. He presented a history of right femoro-popliteal bypass for peripheral arterial occlusive disease and elective surgical treatment for a non-ruptured infrarenal aortic aneurysm (Dacron tube graft). Read More

    Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years.
    Br J Surg 2017 Feb;104(3):166-178
    Vascular Surgery Research Group, Imperial College London, London, UK.
    Background: The erosion of the early mortality advantage of elective endovascular aneurysm repair (EVAR) compared with open repair of abdominal aortic aneurysm remains without a satisfactory explanation.

    Methods: An individual-patient data meta-analysis of four multicentre randomized trials of EVAR versus open repair was conducted to a prespecified analysis plan, reporting on mortality, aneurysm-related mortality and reintervention.

    Results: The analysis included 2783 patients, with 14 245 person-years of follow-up (median 5·5 years). Read More

    Lipoprotein(a)-hyperlipoproteinemia as cause of chronic spinal cord ischemia resulting in progressive myelopathy - successful treatment with lipoprotein apheresis.
    Clin Res Cardiol Suppl 2017 Feb 3. Epub 2017 Feb 3.
    Apheresis Research Institute, Cologne, Germany.
    High concentrations of lipoprotein(a) (Lp(a)) represent an important independent and causal risk factor associated with adverse outcome in atherosclerotic cardiovascular disease (CVD). Effective Lp(a) lowering drug treatment is not available. Lipoprotein apheresis (LA) has been proven to prevent cardiovascular events in patients with Lp(a)-hyperlipoproteinemia (Lp(a)-HLP) and progressive CVD. Read More

    C-Reactive Protein Predicts Incidence of Dementia in an Elderly Asian Community Cohort.
    J Am Med Dir Assoc 2017 Jan 31. Epub 2017 Jan 31.
    Population Health Science Institute, National Health Research Institutes, Miaoli, Taiwan. Electronic address:
    Background: Many studies have investigated the association between markers for peripheral inflammation and risk of dementia, but the results have been conflicting. We aimed to evaluate the association between a specific inflammation marker, C-reactive protein (CRP), and dementia in an elderly Asian community cohort.

    Methods: The cohort included 1436 individuals (ages 65 and older) from a national representative sample in Taiwan. Read More

    Are mast cells important in diabetes?
    Pol J Pathol 2016 ;67(3):199-206
    Postgraduate Medical School, Università G. d'Annunzio, Chieti, Italy.
    Diabetes is a metabolic disorder characterized by hyperglycemia and associated with microvascular and macrovascular syndromes mediated by mast cells. Mast cells are activated through cross-linking of their surface high affinity receptors for IgE (FcRI) or other antigens, leading to degranulation and release of stored inflammatory mediators, and cytokines/chemokines without degranulation. Mast cells are implicated in innate and acquired immunity, inflammation and metabolic disorders such as diabetes. Read More

    Crosstalk between oxidative and nitrosative stress and arterial stiffness.
    Curr Vasc Pharmacol 2017 Feb 1. Epub 2017 Feb 1.
    Department of Functional Sciences, Discipline of Pathophysiology, "Victor Babes" University of Medicineand Pharmacy, Timisoara, Romania.
    Arterial stiffness, the expression of reduced arterial elasticity, is an effective predictor of cardiovascular disorders. Oxidative stress is an imbalance between exposure to toxic reactive oxygen species (ROS) and antioxidant systems. The increase in reactive nitrogen species (RNS) is termed nitrosative stress. Read More

    A model to estimate cost-savings in diabetic foot ulcer prevention efforts.
    J Diabetes Complications 2017 Jan 21. Epub 2017 Jan 21.
    Southern Arizona Limb Salvage Alliance (SALSA), University of Arizona College of Medicine, Tucson, AZ.
    Background: Sustained efforts at preventing diabetic foot ulcers (DFUs) and subsequent leg amputations are sporadic in most health care systems despite the high costs associated with such complications. We sought to estimate effectiveness targets at which cost-savings (i.e. Read More

    Impact of betablockers on general and local outcome in patients hospitalized for lower extremity peripheral artery disease: The COPART Registry.
    Medicine (Baltimore) 2017 Feb;96(5):e5916
    aDepartment of Vascular Medicine, Hôpital européen Georges-Pompidou, assistance publique hôpitaux de Paris, APHP, Paris Descartes University, Sorbonne Paris Cite, PARCC, INSERM U970, Paris bDepartment of Vascular Medicine, Rangueil Hospital, Institute of Molecular Medicine of Rangueil, INSERM U858 cDepartment of Biostatistics, Rangueil Hospital, Toulouse dDepartment of Thoracic and Cardiovascular Surgery and Angiology, Dupuytren University Hospital, Limoges eDepartment of Cardiology, Dupuytren University Hospital, INSERM U1094, Limoges fDepartment of Vascular Medicine, Saint-André Hospital, Bordeaux, France.
    Lower extremity peripheral artery disease (PAD) is one manifestation of atherosclerosis. Patients with PAD have an increased rate of mortality due to concurrent coronary artery disease and hypertension. Betablockers (BB) may, therefore, be prescribed, especially in case of heart failure. Read More

    Cross-sectional study of the ankle-brachial index and cardiovascular risk factors in postmenopausal women.
    Kardiol Pol 2017 Feb 2. Epub 2017 Feb 2.
    Clinic of Vascular Surgery and Angiology, Collegium Medicum of Nicolaus Copernicus University in Bydgoszcz.
    Background: The incidence of peripheral artery disease (PAD) and cardiovascular events in the female population has been on the increase. A: IM: To analyze the risk factors of a cardiovascular event and PAD in women and to assess the usefulness of the ankle-brachial index (ABI).

    Methods: Evaluation of selected parameters in a cohort of 365 women living in the same district. Read More

    Numerical Modeling of Nitinol Stent Oversizing in Arteries with Clinically Relevant Levels of Peripheral Arterial Disease: The Influence of Plaque Type on the Outcomes of Endovascular Therapy.
    Ann Biomed Eng 2017 Feb 1. Epub 2017 Feb 1.
    Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstrasse 78, 3014, Bern, Switzerland.
    Oversizing of the Nitinol stents in the femoro-popliteal arterial tract is commonly performed by clinicians and further encouraged by stent manufacturers. However, in spite of the procedure's supposed benefits of strong wall apposition and increased luminal gain, its effects on the mechanical behavior of arteries with peripheral arterial disease are not fully clear. In this study, finite element (FE) analyses of endovascular revascularization of an idealized artery with 70% stenosis and three different plaque types have been performed to examine the influence of Nitinol stent oversizing on the arterial stresses and acute lumen gain. Read More

    Calcification of arteries supplying the gastric tube increases the risk of anastomotic leakage after esophagectomy with cervical anastomosis.
    J Thorac Dis 2016 Dec;8(12):3551-3562
    Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
    Background: Anastomotic leak is an important cause of morbidity and mortality after esophagectomy for esophageal cancer patients. Calcification of the arteries supplying the gastric tube has been found to be associated with leakage after esophagectomy with cervical anastomosis in Europeans. The purpose of this study is to evaluate the association between calcifications of the supplying arteries of the gastric tube and the occurrence of anastomotic leakage after esophagectomy with cervical anastomosis in Chinese patients with esophageal cancer. Read More

    Emerging role of exosome-mediated intercellular communication in vascular remodeling.
    Oncotarget 2017 Jan 28. Epub 2017 Jan 28.
    Department of Cardiology, Cardiovascular Key Lab of Zhejiang Province, Second Affiliated Hospital, Zhejiang University College of Medicine, Hang Zhou, Zhejiang, P.R. China.
    Vascular remodeling refers to the alternations of function and structure in vasculature. A complex autocrine/paracrine set of cellular interaction is involved in vascular remodeling. Exosome, a newly identified natural nanocarrier and intercellular messenger, plays a pivotal role in regulating cell-to-cell communication. Read More

    Actions of Quercetin, a Polyphenol, on Blood Pressure.
    Molecules 2017 Jan 29;22(2). Epub 2017 Jan 29.
    Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
    Disorder of blood pressure control causes serious diseases in the cardiovascular system. This review focuses on the anti-hypertensive action of quercetin, a flavonoid, which is one of the polyphenols characterized as the compounds containing large multiples of phenol structural units, by varying the values of various blood pressure regulatory factors, such as vascular compliance, peripheral vascular resistance, and total blood volume via anti-inflammatory and anti-oxidant actions. In addition to the anti-inflammatory and anti-oxidant actions of quercetin, we especially describe a novel mechanism of quercetin's action on the cytosolic Cl(-) concentration ([Cl(-)]c) and novel roles of the cytosolic Cl(-) i. Read More

    Pho4 Is Essential for Dissemination of Cryptococcus neoformans to the Host Brain by Promoting Phosphate Uptake and Growth at Alkaline pH.
    mSphere 2017 Jan-Feb;2(1). Epub 2017 Jan 25.
    Fungal Pathogenesis Laboratory, Centre for Infectious Diseases and Microbiology, The Westmead Institute for Medical Research, Westmead, NSW, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, NSW, Australia; The Westmead Clinical School, Sydney Medical School, The University of Sydney, Westmead, NSW, Australia.
    Phosphate acquisition by fungi is regulated by the phosphate-sensing and acquisition (PHO) signaling pathway. Cryptococcus neoformans disseminates from the lung to the brain and is the commonest cause of fungal meningitis worldwide. To investigate the contribution of PHO signaling to cryptococcal dissemination, we characterized a transcription factor knockout strain (hlh3Δ/pho4Δ) defective in phosphate acquisition. Read More

    Phase Ib Safety, Two-Dose Study of MultiGeneAngio in Patients with Chronic Critical Limb Ischemia.
    Mol Ther 2017 Jan 28. Epub 2017 Jan 28.
    Rappaport Faculty of Medicine, Technion IIT, Haifa 3200003, Israel; VESSL Therapeutics Ltd., Haifa 3436212, Israel.
    Critical limb ischemia (CLI) is the most severe presentation of peripheral arterial disease. We developed cell-based therapy entailing intra-arterial injection of autologous venous endothelial cells (ECs) modified to express angiopoietin 1, combined with autologous venous smooth muscle cells (SMCs) modified to express vascular endothelial growth factor. This combination promoted arteriogenesis in animal models and was safe in patients with limiting claudication. Read More

    Genetic polymorphisms in key hypoxia-regulated downstream molecules and phenotypic correlation in prostate cancer.
    BMC Urol 2017 Jan 31;17(1):12. Epub 2017 Jan 31.
    ICBAS, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal.
    Background: In this study we sought if, in their quest to handle hypoxia, prostate tumors express target hypoxia-associated molecules and their correlation with putative functional genetic polymorphisms.

    Methods: Representative areas of prostate carcinoma (n = 51) and of nodular prostate hyperplasia (n = 20) were analysed for hypoxia-inducible factor 1 alpha (HIF-1α), carbonic anhydrase IX (CAIX), lysyl oxidase (LOX) and vascular endothelial growth factor (VEGFR2) immunohistochemistry expression using a tissue microarray. DNA was isolated from peripheral blood and used to genotype functional polymorphisms at the corresponding genes (HIF1A +1772 C > T, rs11549465; CA9 + 201 A > G; rs2071676; LOX +473 G > A, rs1800449; KDR - 604 T > C, rs2071559). Read More

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