77,800 results match your criteria Peripheral Vascular Disease


Cardiovascular Disease: Lower Extremity Peripheral Artery Disease.

FP Essent 2019 Apr;479:11-15

Womack Army Medical Center Department of the Army, WAMC Stop A 2817 Reilly Rd, Ft Bragg, NC 28310-7301.

Lower extremity peripheral artery disease (PAD) refers to atherosclerotic disease that involves the iliac, femoral, or more distal arteries of the lower extremities. This condition affects 8 to 12 million Americans. Risk factors include advanced age, hypertension, dyslipidemia, diabetes, and cigarette smoking. Read More

View Article

Download full-text PDF

Source

Quality of Life in Individuals With Peripheral Arterial Disease Who Underwent Toe Amputations: A Descriptive, Cross-sectional Study.

Wound Manag Prev 2019 Apr;65(4):34-40

University of Virginia Health System, Charlottesville, VA.

Studies have shown above- or below-the-knee amputation has a profound impact on physical, mental, and emotional health; the impact of having a toe(s) amputated is unknown.

Purpose: This descriptive research study measured health-related quality of life (HRQoL) using the Vascular Quality-of-Life Questionnaire-6 (VascuQol-6) among persons with peripheral arterial disease (PAD) who had undergone toe amputations.

Methods: A list of 127 patients discharged from the hospital in 2016 with a diagnosis of PAD and toe amputation was provided to the investigator. Read More

View Article

Download full-text PDF

Source

The relationship between adrenal incidentalomas and mortality risk.

Eur Radiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, 111 E 210th Street, Bronx, New York, NY, 10467, USA.

Objective: To determine all-cause mortality risk in patients with and without adrenal incidentaloma.

Methods: Retrospective cohort study of patients with CT abdomen performed within 24 h of emergency room presentation at an academic medical center from January 1, 2005, to December 31, 2009, without history of adrenal disease, adrenal lab testing, or cancer. Incidentaloma cohort identified by database query of imaging reports followed by manual review and matched to no-nodule controls at 3:1 on age ± 1 year and exam date ± 3 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-019-06202-yDOI Listing

Endovascular Strategies in the Management of Acute Limb Ischemia.

Vasc Specialist Int 2019 Mar;35(1):4-9

Department of Surgery, Division of Vascular Surgery, Northshore University Health Systems, A Teaching Affiliate of the University of Chicago Pritzker School of Medicine, Evanston, USA.

Acute limb ischemia (ALI) represents one of the most common emergent scenarios encountered by a vascular specialist. Despite expedient revascularization, high rates of limb loss are reported along with high mortality rates which are second only to ruptured abdominal aortic aneurysms. Surgical revascularization is standard of care. Read More

View Article

Download full-text PDF

Source
http://www.vsijournal.org/journal/DOIx.php?id=10.5758/vsi.20
Publisher Site
http://dx.doi.org/10.5758/vsi.2019.35.1.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453593PMC
March 2019
1 Read

Immune mechanisms of hypertension.

Nat Rev Immunol 2019 Apr 16. Epub 2019 Apr 16.

Centre for Cardiovascular Biology and Disease Research, Department of Physiology, Anatomy and Microbiology, La Trobe University, Melbourne, Victoria, Australia.

Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke. Traditionally, hypertension has been regarded as a disorder of two systems that are involved in the regulation of salt-water balance and cardiovascular function: the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system (SNS). However, current treatments that aim to limit the influence of the RAAS or SNS on blood pressure fail in ~40% of cases, which suggests that other mechanisms must be involved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-019-0160-5DOI Listing

Efficacy and Feasibility of Pain management and Patient Education for Physical Activity in Intermittent claudication (PrEPAID): protocol for a randomised controlled trial.

Trials 2019 Apr 16;20(1):222. Epub 2019 Apr 16.

Department of Physiotherapy and Paramedicine, School of Health and Life Sciences, Glasgow Caledonain University, Glasgow, UK.

Background: Physical activity (PA) improves functional capacity and quality of life and provides secondary prevention benefits in individuals with peripheral arterial disease (PAD) and intermittent claudication (IC). However, pain and patient lack of knowledge are key barriers to the uptake of, and adherence to, PA recommendations. This trial will test the efficacy and feasibility of a non-invasive pain management intervention with and without patient education to improve PA in individuals with PAD and IC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-019-3307-6DOI Listing

Current Topics in Vascular Access: Superficialization of Arteriovenous Fistula.

Contrib Nephrol 2019 16;198:1-11. Epub 2019 Apr 16.

Department of Internal Medicine, Division of Kidney and Dialysis, Hyogo College of Medicine, Nishinomiya, Japan.

Background: An arteriovenous fistula (AVF) is considered the gold standard modality of vascular access (VA) for maintenance hemodialysis (HD) because of its superior patency, few complications, provision of high quality of life, and low risk of patient mortality. The rapid growth of the aging population and the high prevalence of comorbidities, particularly diabetes mellitus and peripheral vascular disease, in patients requiring HD inevitably deteriorate the ability to construct and maintain a conventional AVF because of these patients' insufficient vascular adaptability. Furthermore, a substantial proportion of patients undergoing HD encounter non-maturation AVF failure and mis-cannulation-related complications, resulting in the need for a temporary VA procedure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496530DOI Listing
April 2019
1 Read

[Ghrelin Physiology and Pathophysiology: Focus on the Cardiovascular System].

Kardiologiia 2019 Apr 13;59(3):60-67. Epub 2019 Apr 13.

Research Institute for Complex Issues of Cardiovascular Diseases Kemerovo State Medical University.

Ghrelin is a multifunctional peptide hormone, mainly synthesized by P / D1 cells of the stomach fundus mucosa. Its basic effect, which is realized via GHS-R1 α receptor in the arcuate and the ventromedial nucleuses of hypothalamus, is stimulation of the synthesis of pituitary hormones. Ghrelin is involved in control of appetite and energy balance, regulation of carbohydrate and lipid metabolism, cell proliferation and apoptosis, as well as modulation of functioning of gastrointestinal, cardiovascular, pulmonary and immune systems. Read More

View Article

Download full-text PDF

Source
https://lib.ossn.ru/jour/article/view/569
Publisher Site
http://dx.doi.org/10.18087/cardio.2019.3.10220DOI Listing
April 2019
1 Read

Vascular Tests for Dermatologists.

Am J Clin Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Dermatologists encounter patients with a variety of lower extremity ulcers including those related to venous insufficiency and peripheral arterial disease. Vascular studies, including ankle brachial pressure index, toe pressure, toe brachial index, Doppler arterial waveform, Duplex ultrasonography, and angiography, play an essential role in the prevention, diagnosis, and management of vascular diseases. In fact, dermatologists are often the first medical providers to see patients with complex vascular conditions. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s40257-019-00441-x
Publisher Site
http://dx.doi.org/10.1007/s40257-019-00441-xDOI Listing
April 2019
1 Read

Predictive value of P-selectin and endothelin-1 for vascular restenosis after interventional procedures for peripheral artery disease.

Exp Ther Med 2019 May 18;17(5):3907-3912. Epub 2019 Mar 18.

Department of Science of Epidemic Febrile Disease, School of Basic Medical Sciences, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China.

Peripheral artery disease (PAD) is caused by the building up of plaques in the arteries that carry blood to the lower limbs. The present study aimed to assess the predictive value of the plasma levels of P-selectin (Ps) or endothelin-1 (ET-1) regarding the occurrence of vascular restenosis after endovascular therapy for PAD. Patients with or without vascular restenosis confirmed by computed tomography angiography after endovascular therapy between March and December 2015 (n=20 per group) were enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2019.7407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447944PMC

Correlation between angiopoietin-like proteins in inflammatory mediators in peripheral blood and severity of coronary arterial lesion in patients with acute myocardial infarction.

Exp Ther Med 2019 May 13;17(5):3495-3500. Epub 2019 Mar 13.

Department of Radiology, Pingjin Hospital Heart Center and Tianjin, Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Logistics University of PAPF, Tianjin 300162, P.R. China.

The effects of angiopoietin-like protein 2 (Angptl 2) and interleukin-6 (IL-6) in inflammatory mediators on the severity of coronary arterial lesion in patients with acute myocardial infarction were investigated. One hundred and twenty-six patients with acute myocardial infarction admitted to Tianjin Union Medical Center (the myocardial infarction group) and 133 healthy individuals (the control group) were selected for retrospective analysis from January 2013 to December 2015. The levels of Angptl 2 and IL-6 in serum of patients were detected by enzyme linked immunosorbent assay (ELISA), and the correlation analysis between the levels and the degree of coronary stenosis in patients with myocardial infarction was conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2019.7386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447790PMC

Factors related to peripheral arterial disease in patients undergoing hemodialysis: the potential role of monocyte chemoattractant protein-1.

Hypertens Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Nuclear Medicine, General Hospital "LAΪKO", Athens, Greece.

Peripheral arterial disease (PAD) is substantially prevalent among patients in the end stage of renal disease (ESRD). We considered factors related to peripheral arterial disease in patients undergoing hemodialysis including the important role of monocyte chemoattractant protein-1 (MCP-1) serum concentrations. We studied 150 patients in on-line-predilution hemodiafiltration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41440-019-0259-xDOI Listing

Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels.

Mol Ther 2019 Mar 30. Epub 2019 Mar 30.

Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

Endothelial surface and circulating glycoprotein von Willebrand factor (vWF) regulates platelet adhesion and is associated with thrombotic diseases, including ischemic stroke, myocardial infarction, and peripheral vascular disease. Thrombosis, as manifested in these diseases, is the leading cause of disability and death in the western world. Current parenteral antithrombotic and thrombolytic agents used to treat these conditions are limited by a short therapeutic window, irreversibility, and major risk of hemorrhage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymthe.2019.03.016DOI Listing

Pain Intensity, Pressure Pain Hypersensitivity, Central Sensitization, and Pain Catastrophizing Related to Vascular Alterations in Raynaud's Phenomenon: A Preliminary Case-Control Study.

Pain Med 2019 Apr 15. Epub 2019 Apr 15.

Instituto de Investigación Biosanitaria Granada, Department of Physical Therapy, Faculty of Health Science, University of Granada, Granada, Spain.

Objective: To evaluate pain intensity, widespread pressure pain, central sensitization (CS), and catastrophizing between subjects with primary and secondary Raynaud's phenomenon (RP) and healthy controls and to compare the relationships between vascular impairment and pain perception.

Methods: A preliminary case-control study was performed with a total sample of 57 participants (37 with RP). Sociodemographic data, clinical/vascular data, and pain variables (pain intensity, pressure pain sensitivity, pain magnitude and threshold, CS, and catastrophizing) were registered. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/pm/pnz089DOI Listing

Associations between lung and endothelial function in early middle age.

Respirology 2019 Apr 15. Epub 2019 Apr 15.

Firestone Institute for Respiratory Health, Michael de Groote School of Medicine, McMaster University and St Joseph's Healthcare, Hamilton, ON, Canada.

Background And Objective: Chronic lung disease is associated with impaired endothelial function and this may be a risk factor for poor cardiovascular health. It is unknown if there is an association between lung and endothelial function in the general population. We investigated associations between lung and endothelial function in a population-based cohort of 38-year-old men and women. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13556
Publisher Site
http://dx.doi.org/10.1111/resp.13556DOI Listing
April 2019
1 Read

Accepted but Unacceptable: Peripheral IV Catheter Failure.

J Infus Nurs 2019 May/Jun;42(3):151-164

Portsmouth Regional Hospital, Department of Cardiothoracic and Vascular Surgery, Portsmouth, New Hampshire (Dr Helm); University of California, Division of Infectious Diseases, Los Angeles, California (Dr Klausner and Ms Huang); and Eastern Maine Medical Center, Division of Cardiovascular Surgery, Bangor, Maine (Dr Klemperer). Robert E. Helm, MD, is a cardiothoracic surgeon in the Department of Cardiothoracic and Vascular Surgery at the Portsmouth Regional Hospital in Portsmouth, New Hampshire. Jeffrey D. Klausner, MD, MPH, is a professor of medicine in the Division of Infectious Diseases at the University of California, Los Angeles. John D. Klemperer, MD, is a cardiothoracic surgeon in the Division of Cardiovascular Surgery at the Eastern Maine Medical Center in Bangor, Maine. Lori M. Flint, BSN, RN, CCRN, is a critical care nurse. Emily Huang, BA, is a research assistant in the Division of Infectious Diseases at the University of California, Los Angeles.

Peripheral intravenous (IV) catheter insertion, the most common invasive hospital procedure performed worldwide, is associated with a variety of complications and an unacceptably high overall failure rate of 35% to 50% in even the best of hands. Catheter failure is costly to patients, caregivers, and the health care system. Although advances have been made, analysis of the mechanisms underlying the persistent high rate of peripheral IV failure reveals opportunities for improvement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/NAN.0000000000000326DOI Listing
April 2019
1 Read

Popliteal Artery Entrapment Syndrome (PAES) in a 17-Year-Old Adolescent.

Case Rep Vasc Med 2019 11;2019:8540631. Epub 2019 Mar 11.

Division of Angiology, Department of Internal Medicine, University Hospital Graz, Austria.

Introduction: Popliteal artery entrapment syndrome (PAES) is caused by compression of the popliteal artery (PA) due to deranged myotendinous structures. It can be asymptomatic or may present with exercise intolerance, claudication, or even limb-threatening ischemia. The clinical picture depends on the anatomy and degree of vascular compromise. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/crivam/2019/8540631/
Publisher Site
http://dx.doi.org/10.1155/2019/8540631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432725PMC
March 2019
1 Read

Prevalence of And Factors Associated with Healthcare-associated Infections in Slovenian Acute Care Hospitals: Results of the Third National Survey.

Zdr Varst 2019 Mar 26;58(2):62-69. Epub 2019 Mar 26.

Members of the SNHPS III Network are listed at the end of the article Ljubljana, Slovenia.

Introduction: In the third Slovenian national healthcare-associated infections (HAIs) prevalence survey, conducted within the European point prevalence survey of HAIs and antimicrobial use in acute care hospitals, we estimated the prevalence of all types of HAIs and identified factors associated with them.

Methods: Patients were enrolled into a one-day cross-sectional study in November 2017. Descriptive analyses were performed to describe the characteristics of patients, their exposure to invasive procedures and the prevalence of different types of HAIs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2478/sjph-2019-0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455016PMC

Therapeutic Potential of Regulatory T Cells in Preeclampsia-Opportunities and Challenges.

Front Immunol 2019 21;10:478. Epub 2019 Mar 21.

Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.

Inflammation is a central feature and is implicated as a causal factor in preeclampsia and other hypertensive disorders of pregnancy. Inflammatory mediators and leukocytes, which are elevated in peripheral blood and gestational tissues, contribute to the uterine vascular anomalies and compromised placental function that characterize particularly the severe, early onset form of disease. Regulatory T (Treg) cells are central mediators of pregnancy tolerance and direct other immune cells to counteract inflammation and promote robust placentation. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fimmu.2019.00478
Publisher Site
http://dx.doi.org/10.3389/fimmu.2019.00478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448013PMC
March 2019
1 Read

Comorbidities Related to Clinical Outcomes in Patients With Acute Ischemic Stroke Undergoing Mechanical Thrombectomy: Review of Literature and Experience at a Single Comprehensive Stroke Center.

Ochsner J 2019 ;19(1):13-16

Department of Vascular and Interventional Neurology, Ochsner Clinic Foundation, New Orleans, LA.

Recent clinical trials have shown mechanical thrombectomy (MT) to have clinical benefit for patients with acute ischemic stroke. The purpose of this study was to identify comorbid conditions that correlate with functional nonindependence in patients with acute ischemic stroke who underwent MT at a single comprehensive stroke center. Patients who had multiphase computed tomography angiography (MCTA) and subsequently underwent MT were included in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.31486/toj.18.0108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447207PMC
January 2019

Evaluation of various risk factors associated with multidrug-resistant organisms isolated from diabetic foot ulcer patients.

J Lab Physicians 2019 Jan-Mar;11(1):58-62

Department of Surgery, Government Medical College and Hospital, Chandigarh, India.

Aims: Diabetic foot ulcer is a dreaded complication of diabetes. Diabetic foot ulcer patients are often infected with multidrug resistant organism (MDRO) due to chronic course of the wound, inappropriate antibiotics treatment, frequent hospital admission, neuropathy, nephropathy, and peripheral vascular disease.

Materials And Methods: This prospective study was conducted in our 750 bedded hospital for a period of 6 months. Read More

View Article

Download full-text PDF

Source
http://www.jlponline.org/text.asp?2019/11/1/58/254072
Publisher Site
http://dx.doi.org/10.4103/JLP.JLP_106_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437817PMC
April 2019
1 Read

lncRNA-ATB promotes viability, migration, and angiogenesis in human microvascular endothelial cells by sponging microRNA-195.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Vascular Surgery, Jining No. 1 People's Hospital, Jining, China.

The atherosclerosis in the arterial system of the extremities is considered as the major pathogenesis of peripheral arterial disease. The present work aimed to explore the potential role of long noncoding RNA activated by tumor growth factor-β (lncRNA-ATB) on the dysfunction of endothelial cells. Human microvascular endothelial cells (HMEC-1) were transfected with lncRNA-ATB expressing vectors, and then the formation of tubes and expression of proteins associated with angiogenesis were analyzed using microscope and reverse transcription-quantitative polymerase chain reaction (RT-qPCR)/Western blot analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.28692DOI Listing
April 2019
3.263 Impact Factor

Impact of risk factors and surgical techniques in coronary endarterectomy: a network meta-analysis.

Interact Cardiovasc Thorac Surg 2019 Apr 14. Epub 2019 Apr 14.

Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

The goal of this network meta-analysis was to compare the early mortality rate of patients who underwent coronary endarterectomy (CE) combined with coronary artery bypass grafting (CABG) with different techniques and with isolated CABG. This analysis also evaluated potential risk factors in patients who undergo CE. Eighteen studies were included, covering 21 752 different patients, among whom 3352 underwent CE + CABG with either open or closed techniques and 18 400 underwent isolated CABG. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/icvts/ivz090DOI Listing

Treadmill Measured vs. Questionnaire Estimated Changes in Walking Ability in Patients With Peripheral Artery Disease.

Eur J Vasc Endovasc Surg 2019 Apr 11. Epub 2019 Apr 11.

Vascular Surgery Department, University Hospital Centre of Angers, Angers, France; UMR CNRS 6015, INSERM U1083, Mitovasc Institute, Angers, France. Electronic address:

Objective: Determining the maximum walking time (MWT) using the treadmill test is the gold standard method for evaluating walking capacity and treatment effect in patients with peripheral arterial disease (PAD). However, self reported functional disability is important when assessing quality of life. Changes in the Walking Estimated Limitation Calculated by History (WELCH) questionnaire scores were compared with the MWT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejvs.2018.11.015DOI Listing

Marine and plant-based n-3 PUFA and atherosclerotic cardiovascular disease.

Proc Nutr Soc 2019 Apr 15:1-8. Epub 2019 Apr 15.

Department of Cardiology,Aalborg University Hospital,Aalborg,Denmark.

n-3 PUFA may exert favourable effects on several processes that may inhibit the atherosclerotic process. However, the role of n-3 PUFA in lowering the risk of atherosclerotic CVD (ASCVD) has been fiercely debated. In the present paper, we summarise the main findings from previous follow-up studies of intake and studies using adipose tissue as an objective biomarker to investigate exposure to n-3 PUFA in relation to ASCVD risk and discuss some perspectives for further research. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S0029665119000582DOI Listing
April 2019
1 Read

[Treatment of retinopathy of incontinentia pigmenti by anti-vascular endothelial growth factor].

Authors:
X Wang J H Liang

Zhonghua Yan Ke Za Zhi 2019 Apr;55(4):294-301

Beijing Key Laboratory of Vision Loss and Restoration, Ministry of Education, Department of Ophthalmology, People's Hospital, Peking University, Beijing 100044, China.

To investigate the treatment of retinopathy of incontinentia pigmenti by anti-vascular endothelial growth factor. Retrospective study of 5 patients(8 eyes) diagnosed retinopathy of incontinentia pigmenti from 2005 to 2017, including 0 males and 5 females (8 eyes involved) with an average age of 2.4 months(range, 1-5 months). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.04.012DOI Listing
April 2019
1 Read

[Mid-term multi-center outcomes of bilateral radial artery as conduits in coronary artery bypass grafting].

Zhonghua Yi Xue Za Zhi 2019 Apr;99(14):1069-1074

Department of Cardiac Surgery, Hebei Chest Hospital, Shijiazhuang 050041, China.

To evaluate the mid-term outcomes of bilateral radial artery (BRA) grafts in coronary artery bypass grafting (CABG). All perioperative medical records and follow-up results of CABG with BRA grafts in multi-centers of China were analyzed retrospectively. A total of 211 patients (170 males and 41 females) underwent CABG grafting with BRA conduits between August 2013 and September 2018, with a mean age of (56. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.14.007DOI Listing
April 2019
1 Read

Cardiac biomarkers but not measures of vascular atherosclerosis predict mortality in patients with peripheral artery disease.

Clin Chim Acta 2019 Apr 11. Epub 2019 Apr 11.

Angiology, Klinic im Park, Zurich, Switzerland.

Background: Peripheral artery disease (PAD) becomes more prevalent with advancing age and is associated with elevated risk of cardiovascular events and shortened life expectancy. We investigated the prognostic performance of cardiac and vascular biomarkers in a cohort of PAD patients.

Methods: A total of 95 PAD patients were enrolled (mean age 68 years, range 47 to 86 years, 73 males). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00098981193181
Publisher Site
http://dx.doi.org/10.1016/j.cca.2019.04.061DOI Listing
April 2019
3 Reads

Non-specific chest pain and subsequent serious cardiovascular readmissions.

Int J Cardiol 2019 Apr 2. Epub 2019 Apr 2.

Keele Cardiovascular Research Group, Keele University, Stoke-on-Trent, UK; Royal Stoke University Hospital, Stoke-on-Trent, UK. Electronic address:

Background: The rates of readmission for serious cardiovascular events among patients admitted with a diagnosis of non-specific chest pain are unknown.

Methods: A national retrospective cohort study in the United States was undertaken to evaluate the rates, trends and predictors of readmission for serious cardiovascular events (acute coronary syndrome (ACS), pulmonary embolism (PE) and aortic dissection (AD)) after an inpatient episode with a primary diagnosis of non-specific chest pain.

Results: Among 1,172,430 patients with an index diagnosis of non-specific chest pain between 2010 and 2014, 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2019.04.001DOI Listing

Left Ventricular and Proximal Aorta Coupling in Magnetic Resonance Imaging: Aging Together?

Am J Physiol Heart Circ Physiol 2019 Apr 12. Epub 2019 Apr 12.

Division of cardiology, Johns Hopkins University, School of Medicine.

Background: The importance of aorta-ventricular coupling in cardiovascular disease is recognized but underestimated. The contribution of the age-related decline in ascending aortic function in comparison to characteristic impedance and total peripheral resistance on left ventricular function and remodeling is poorly studied. Our aim was to evaluate the relation of proximal aortic distensibility and impedance with left ventricular geometry and function in asymptomatic individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpheart.00694.2018DOI Listing

Diabetic foot infections: a comprehensive overview.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):26-37

Diabetes Care Unit, Endocrinology, University Hospital "A. Gemelli", Catholic University of the Sacred Heart, Rome, Italy.

Diabetic foot ulcers (DFUs), a micro-vascular complication, are associated with a substantial increase in morbidity and mortality. DFUs are a complicated mixture of neuropathy, peripheral arterial diseases, foot deformities, and infections. Foot infections are frequent and potentially devastating complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26355/eurrev_201904_17471DOI Listing
April 2019
1 Read

Screening and Management of Depression in Patients With Cardiovascular Disease: JACC State-of-the-Art Review.

J Am Coll Cardiol 2019 Apr;73(14):1827-1845

Depression and Anxiety Center for Discovery and Treatment, Department of Psychiatry, and Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

Depression is a common problem in patients with cardiovascular disease (CVD) and is associated with increased mortality, excess disability, greater health care expenditures, and reduced quality of life. Depression is present in 1 of 5 patients with coronary artery disease, peripheral artery disease, and heart failure. Depression complicates the optimal management of CVD by worsening cardiovascular risk factors and decreasing adherence to healthy lifestyles and evidence-based medical therapies. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07351097193051
Publisher Site
http://dx.doi.org/10.1016/j.jacc.2019.01.041DOI Listing
April 2019
1 Read

Killer-cell immunoglobulin-like receptor ligand mismatch cord blood transplantation in high-risk neuroblastoma.

Pediatr Int 2019 Apr 11. Epub 2019 Apr 11.

Department of Pediatrics, Showa University Fujigaoka Hospital, Japan.

Background: The prognosis of high-risk neuroblastoma-stage 4 with bone marrow metastasis, MYCN amplified, or refractory neuroblastoma is poor. To date, no standard treatment has been established. In an attempt to measure the survival rates of four selected cases, we challenged the killer-cell immunoglobulin-like receptor ligand mismatch cord blood transplantation in the graft-versus-host disease with reduced intensity conditioning. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ped.13861DOI Listing
April 2019
1 Read

Retrograde dorsalis pedis angiosomal flow compromised by small puncture wound leading to transmetatarsal amputation.

Foot (Edinb) 2019 Feb 14;39:60-67. Epub 2019 Feb 14.

Foot and Ankle Surgery Resident, Dept. of Orthopedics, John Peter Smith Hospital, 1500 S. Main Street, Fort Worth, TX, 76104, United States.

Pedal puncture wounds can precipitate a variety of complications, often resulting from a delay in treatment. Although the risk of infection predominates, direct vascular insult and subsequent ischemia is a lesser reported complication of these injuries. Consequently, this may have morbid results, especially on a background of pre-existing peripheral vascular disease. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09582592183014
Publisher Site
http://dx.doi.org/10.1016/j.foot.2019.02.007DOI Listing
February 2019
2 Reads

Identification of atrial fibrillation-associated lncRNAs in atria from patients with rheumatic mitral valve disease.

Microsc Res Tech 2019 Apr 11. Epub 2019 Apr 11.

Department of Cardiovascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Objective: We analysed lncRNA expression profiles in atrial samples from patients with rheumatic mitral valve disease (RMVD) to identify the potential differences in atrial fibrillation (AF)-associated lncRNAs between RMVD patients with AF and sinus rhythm (SR).

Methods: Masson's trichrome staining and scanning electron microscopy were performed to evaluate the tissue morphology. Western blotting was performed to detect the expression of fibrosis-related proteins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jemt.23261DOI Listing
April 2019
1 Read

Nailfold Capillaroscopy of Resting Peripheral Blood Flow in Exfoliation Glaucoma and Primary Open-Angle Glaucoma.

JAMA Ophthalmol 2019 Apr 11. Epub 2019 Apr 11.

Einhorn Clinical Research Center, Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York.

Importance: Systemic blood flow alterations have been described using video nailfold capillaroscopy (NFC) in high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) variants of primary open-angle glaucoma (POAG). To date, no previous studies have explored alterations in nailfold capillary blood flow in exfoliation glaucoma (XFG).

Objective: To investigate the measure of peripheral blood flow as a surrogate marker of systemic vascular involvement in patients with XFG, HTG, and NTG, as well as in individuals serving as controls, using NFC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaophthalmol.2019.0434DOI Listing

Cell therapy of critical limb ischemia-problems and prospects.

Vasa 2019 Apr 10:1-11. Epub 2019 Apr 10.

2 Division of Vascular Surgery, Palo Alto Medical Foundation, Burlingame, USA.

Cell therapy is proposed for indirect revascularization for the patient's incurable by endovascular or surgical revascularization. The therapy with stem cells (SCs) or progenitor cells is assumed to be more efficient as compared with protein or gene therapy not only because of their direct vasculogenic properties, but also thanks to their paracrine effect via secretion of manifold biologically active substances. This review gives an overview of the potential of SC-based therapy for critical limb ischemia (CLI), putative mechanism underlying cell therapy, and comparison of cell therapy to angiogenesis gene therapy in CLI treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1024/0301-1526/a000787DOI Listing

Antithrombotic Therapy in Patients With Atrial Fibrillation After Percutaneous Coronary Intervention During 2-Year Follow-Up, from a Nationwide Population Study.

Am J Cardiol 2019 Mar 16. Epub 2019 Mar 16.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Patients with atrial fibrillation (AF) who underwent percutaneous coronary intervention (PCI) are recommended to receive oral anticoagulants (OAC) and concomitant antiplatelet agents followed by OAC monotherapy continued beyond a year after PCI. However, long-term prescription patterns of antithrombotic therapy in real-world clinical practice were not fully investigated. From the National Health Insurance Service database of Korea, we obtained records of patients with AF who underwent PCI between 2009 and 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjcard.2019.03.024DOI Listing
March 2019
1 Read

Peripheral arterial occlusive disease operative case volume in the final years of 5+2 and 0+5 vascular training paradigms.

Surgery 2019 Apr 6. Epub 2019 Apr 6.

Albert Einstein College of Medicine, Bronx, NY; Division of Vascular Surgery, Montefiore Medical Center, Bronx, NY. Electronic address:

Background: Peripheral arterial occlusive disease constitutes a substantial portion of clinical practice in vascular surgery and, as such, trainees must graduate with proficiency in endovascular and open procedures to become capable vascular surgeons. Case volume for 0+5 integrated vascular surgery residents in the chief and junior years was compared with their 5+2 fellowship counterparts for the treatment of peripheral arterial occlusive disease.

Methods: In this retrospective review, operative volume for peripheral arterial occlusive disease cases in both vascular training paradigms was evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.surg.2019.02.021DOI Listing
April 2019
4 Reads

A Low-Molecular-Weight Polyethylenimine/pDNA-VEGF Polyplex System Constructed in a One-Pot Manner for Hindlimb Ischemia Therapy.

Pharmaceutics 2019 Apr 8;11(4). Epub 2019 Apr 8.

Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.

Peripheral arterial disease (PAD) is often characterized by continued reduction in blood flow supply to limbs. Advanced therapeutic strategies like gene therapy could potentially be applied to limb ischemia therapy. However, developing a gene delivery system with low toxicity and high efficiency remains a great challenge. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/pharmaceutics11040171DOI Listing

Evaluation of the relationship between plaque formation leading to symptomatic carotid artery stenosis and cytomegalovirus by investigating the virus DNA.

Arch Med Sci Atheroscler Dis 2019 4;4:e19-e24. Epub 2019 Mar 4.

Department of Cardiovascular Surgery, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

Introduction: The most common etiologic factor of coronary artery disease (CAD), carotid artery disease, and peripheral artery disease is atherosclerosis. In our study, we aimed to show the effect of cytomegalovirus (CMV), which can occur almost everywhere in the human body, on triggering the chronic inflammatory process in the pathophysiology of atherosclerosis, and its presence and impact in the plaques leading to carotid artery stenosis.

Material And Methods: Thirty-six patients, who underwent carotid endarterectomy at the Department of Cardiovascular Surgery, Istanbul University Istanbul Medical Faculty between April 2017 and April 2018, were included in this study upon their consent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/amsad.2019.83304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451143PMC
March 2019
2 Reads

Evaluation of hs-CRP and sLOX-1 Levels in Moderate-to-High Risk Acute Coronary Syndromes.

Endocr Metab Immune Disord Drug Targets 2019 04 8. Epub 2019 Apr 8.

Başkent University Faculty of Medicine, Ankara, Turkey

Objective: Risk stratification and prompt treatment are essential for the management of acute coronary syndromes (ACS) and prediction of future prognosis. Subclinical vascular inflammation and novel biomarkers play an important role in the clinical evaluation of ACS patients.

Methods: We enrolled patients who were admitted to emergency service with unstable angina or non- ST segment elevated ACS (NSTE-ACS) in the study population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1871530319666190408145905DOI Listing
April 2019
1 Read

Macrovascular complications of type 2 diabetes mellitus.

Curr Vasc Pharmacol 2019 Apr 5. Epub 2019 Apr 5.

Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia; Institute of Health Technologies, Tallinn University of Technology, Tallinn. Estonia.

Background: Type 2 diabetes mellitus (T2DM) has emerged as a pandemic. It has different complications, both microvascular and macrovascular.

Objective: The purpose of this review is to summarize the different types of macrovascular complications associated with T2DM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161117666190405165151DOI Listing
April 2019
1 Read

PI3K activity in dendritic cells exerts paradoxical effects during autoimmune inflammation.

Mol Immunol 2019 Apr 5;111:32-42. Epub 2019 Apr 5.

Institute for Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism for Rheumatoid Arthritis and Thrombosis Research, Vienna, Austria. Electronic address:

The peripheral activation of autoreactive T cells and subsequent central nervous system (CNS) immune cell infiltration are key events relevant for experimental autoimmune encephalomyelitis (EAE), a commonly employed multiple sclerosis (MS) model, influenced by T1 and T17 mediated immunity. The phosphoinositide-3-kinase (PI3K)-AKT kinase pathway modulates outcome during EAE, with direct actions of PI3K on adaptive immunity implicated in deleterious and effects on antigen presenting cells involved in beneficial responses during EAE. Here, by genetically deleting the regulatory subunit of Class Ia PI3K, p85α, in selective myeloid cells, we aimed to resolve the impact of PI3K in EAE. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01615890193003
Publisher Site
http://dx.doi.org/10.1016/j.molimm.2019.03.015DOI Listing
April 2019
2 Reads

Response by Itoga et al to Letter Regarding Article, "Association of Blood Pressure Measurements With Peripheral Arterial Disease Events".

Circulation 2019 Apr;139(15):1855-1856

Division of Nephrology, Department of Medicine (T.I.C.), Stanford University School of Medicine, CA.

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.0
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039293DOI Listing
April 2019
2 Reads

Are two internal thoracic grafts better than one? An analysis of 5301 cases.

Eur J Cardiothorac Surg 2019 Apr 8. Epub 2019 Apr 8.

Department of Cardiothoracic Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: Although bilateral internal thoracic artery (BITA) grafting is associated with improved survival, many surgeons are reluctant to use this technique due to its greater complexity and the potentially increased risk of sternal infection. This observational study examined if BITA grafting provides improved outcomes compared with single internal thoracic artery (SITA) grafting in patients with multivessel coronary disease.

Methods: Patients in our institution who underwent BITA grafting during 1996-2011 were compared to those who underwent SITA grafting during the same period. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/ejcts/advance-article/doi/10.1093/e
Publisher Site
http://dx.doi.org/10.1093/ejcts/ezz094DOI Listing
April 2019
1 Read

Cystic Fibrosis Transmembrane Conductance Regulator Genotype, Not Circulating Catecholamines, Influences Cardiovascular Function in Patients with Cystic Fibrosis.

Clin Med Insights Circ Respir Pulm Med 2019 29;13:1179548419835788. Epub 2019 Mar 29.

Department of Kinesiology, University of Minnesota, Minneapolis, MN, USA.

Background: Cystic fibrosis (CF) is a genetic disease affecting multiple organ systems of the body and is characterized by mutation in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR). Previous work has shown that a single dose of aβ-agonist increases cardiac output (Q) and stroke volume (SV) and decreases systemic vascular resistance (SVR) in healthy subjects. This effect is attenuated in patients with CF; however, the mechanism is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179548419835788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442074PMC
March 2019
1 Read

Cardio-Oncology Rehabilitation to Manage Cardiovascular Outcomes in Cancer Patients and Survivors: A Scientific Statement From the American Heart Association.

Circulation 2019 Apr 8:CIR0000000000000679. Epub 2019 Apr 8.

Cardiovascular disease is a competing cause of death in patients with cancer with early-stage disease. This elevated cardiovascular disease risk is thought to derive from both the direct effects of cancer therapies and the accumulation of risk factors such as hypertension, weight gain, cigarette smoking, and loss of cardiorespiratory fitness. Effective and viable strategies are needed to mitigate cardiovascular disease risk in this population; a multimodal model such as cardiac rehabilitation may be a potential solution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIR.0000000000000679DOI Listing
April 2019
2 Reads

High-nitrate salad increased plasma nitrates/nitrites and brachial artery flow-mediated dilation in postmenopausal women: A pilot study.

Nutr Res 2019 Feb 22. Epub 2019 Feb 22.

College of Health Solutions, Arizona State University, Phoenix, AZ 85004; School of Life Sciences, Arizona State University, Phoenix, AZ 85004. Electronic address:

Cardiovascular disease risk is elevated in postmenopausal women relative to men of the same age or to younger, premenopausal women. This elevated risk is closely linked to the loss of estrogen, which is a potent stimulator of the vasodilator nitric oxide. While studies have largely supported dietary nitrate supplementation (typically concentrated beetroot juice) to augment plasma nitric oxide, these studies focused mainly on improving vascular fitness of athletes or patient populations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nutres.2019.02.001DOI Listing
February 2019
3 Reads

Tips and tricks for facilitating teaching of Doppler waveforms and ankle-brachial index in undergraduate level: A practical guide.

J Vasc Nurs 2019 Mar 8;37(1):64-68. Epub 2018 Dec 8.

Department of Vascular Surgery, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

Although the measurement of ankle-brachial index (ABI) is considered a fundamental skill in assessment and diagnosis of peripheral arterial disease and a predictive tool for cardiovascular events, real-world practice shows that the experience of many health professionals is far from ideal. Not only teaching and practice of ABI measurement in undergraduate medical curricula are limited but various mistakes in the process of calculation, estimation, and interpretation of ABI results in the postgraduate practice have also been documented. Because vascular surgery is a core subject in our medical school, we deal with the difficulties and challenges that undergraduate medical students and nurses face to measure and comprehend ABI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jvn.2018.10.003DOI Listing
March 2019
1 Read