77,344 results match your criteria Peripheral Vascular Disease


Biobanking: Objectives, Requirements, and Future Challenges-Experiences from the Munich Vascular Biobank.

J Clin Med 2019 Feb 16;8(2). Epub 2019 Feb 16.

DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, 80636 Munich, Germany.

Collecting biological tissue samples in a biobank grants a unique opportunity to validate diagnostic and therapeutic strategies for translational and clinical research. In the present work, we provide our long-standing experience in establishing and maintaining a biobank of vascular tissue samples, including the evaluation of tissue quality, especially in formalin-fixed paraffin-embedded specimens (FFPE). Our Munich Vascular Biobank includes, thus far, vascular biomaterial from patients with high-grade carotid artery stenosis ( = 1567), peripheral arterial disease ( = 703), and abdominal aortic aneurysm ( = 481) from our Department of Vascular and Endovascular Surgery (January 2004⁻December 2018). Read More

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http://dx.doi.org/10.3390/jcm8020251DOI Listing
February 2019

Monocytic C-C chemokine receptor 5 expression increases in in vitro intermittent hypoxia condition and in severe obstructive sleep apnea patients.

Sleep Breath 2019 Feb 18. Epub 2019 Feb 18.

Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan City, Taiwan.

Purpose: Obstructive sleep apnea (OSA) patients have higher risk of cardiovascular disease. C-C chemokine receptor 5 (CCR5), as an important receptor for monocyte recruitment and the initiation of atherosclerosis, was studied under intermittent hypoxia and in OSA patients.

Methods: The expression and function of CCR5 regulated by intermittent hypoxia in monocytic THP-1 cells were investigated in an in vitro intermittent hypoxia culture system. Read More

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http://dx.doi.org/10.1007/s11325-019-01797-4DOI Listing
February 2019
2.869 Impact Factor

Effects of a novel hydrogen sulfide prodrug in a porcine model of acute limb ischemia.

J Vasc Surg 2019 Feb 15. Epub 2019 Feb 15.

Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center-New Orleans, New Orleans, La; Department of Pharmacology, Louisiana State University Health Sciences Center-New Orleans, New Orleans, La. Electronic address:

Objective: Previous studies have shown that hydrogen sulfide (HS) exerts potent proangiogenic properties under in vitro conditions and in rodent models. We sought to determine whether a novel HS prodrug promotes peripheral revascularization in a swine model of acute limb ischemia (ALI).

Methods: ALI was induced in 17 female miniswine via intravascular occlusion of the external iliac. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.08.172DOI Listing
February 2019

A systematic review and meta-analysis of the effects of supervised exercise therapy on modifiable cardiovascular risk factors in intermittent claudication.

J Vasc Surg 2019 Feb 15. Epub 2019 Feb 15.

Department of Vascular Surgery, Erasmus University Medical Centre, Rotterdam, The Netherlands.

Objective: Cardiovascular events, such as myocardial infarction and stroke, contribute significantly to the prognosis of patients with peripheral artery disease. Therefore cardiovascular risk reduction is a vital element of treatment in patients with intermittent claudication (IC). The cardiovascular risk is largely determined by modifiable risk factors, which can be treated with medical care and lifestyle adjustments, such as increasing physical activity. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.10.069DOI Listing
February 2019

Screening Coronary Angiography in Patients with Long-Standing Diabetes Mellitus undergoing Kidney Transplant Evaluation.

Clin Transplant 2019 Feb 18:e13501. Epub 2019 Feb 18.

Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA.

Background: The Utility of coronary angiography in patients with diabetes mellitus undergoing kidney transplant evaluation is unclear. Predictors of critical angiography lesions in these patients will aid in appropriate use of angiography.

Methods: Single center study of 80 patients with ≥ 15 years of diabetes mellitus who underwent a screening coronary angiography despite a negative cardiac stress test. Read More

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http://dx.doi.org/10.1111/ctr.13501DOI Listing
February 2019

Resistance Exercise-Induced Responses in Physiological Factors Linked with Cognitive Health.

J Alzheimers Dis 2019 Feb 13. Epub 2019 Feb 13.

School of Psychology and Exercise Science, Murdoch University, Perth, Western Australia, Australia.

The global population is aging at an unprecedented rate giving rise to a greater prevalence of age-related illnesses such as dementia and vascular disease. Dementia affects approximately 47 million individuals globally with projections of 130 million by the year 2050. Late-onset Alzheimer's disease is the most common form of dementia, accounting for approximately 75% of all cases and is characterized by a progressive decline in cognitive function, memory, and cerebral volume. Read More

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http://dx.doi.org/10.3233/JAD-181079DOI Listing
February 2019

Characteristics of peripheral immune cell subsets in patients with carotid atherosclerosis undergoing carotid endarterectomy.

Arch Med Sci Atheroscler Dis 2018 14;3:e129-e136. Epub 2018 Nov 14.

Department of Anesthesiology, Intensive Therapy and Acute Intoxications, Pomeranian Medical University, Szczecin, Poland.

Introduction: The role of circulating immune cells in the pathophysiology of cerebrovascular accidents is currently under debate. The aim of this study was to characterize peripheral immune cell subsets in patients undergoing carotid endarterectomy (CEA).

Material And Methods: We conducted a prospective observational study in a group of 124 patients with significant carotid stenosis undergoing carotid endarterectomy, both symptomatic and asymptomatic. Read More

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http://dx.doi.org/10.5114/amsad.2018.79537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374565PMC
November 2018

New therapies for the treatment of heart failure: a summary of recent accomplishments.

Ther Clin Risk Manag 2019 22;15:147-155. Epub 2019 Jan 22.

Department of Physiology, Pomeranian Medical University, Szczecin, Poland,

Despite continuous efforts to prevent cardiovascular diseases (CVDs), heart failure prevails as the number one cause of death in developed countries. To properly treat CVDs, scientists had to take a closer look at the factors that contribute to their pathogenesis and either modernize current pharmaceuticals or develop brand new treatments. Enhancement of current drugs, such as tolvaptan and omecamtiv mecarbil, sheds new light on already-known therapies. Read More

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http://dx.doi.org/10.2147/TCRM.S179302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348963PMC
January 2019

Inflammatory biomarkers, vascular procedures of lower limbs, and wound healing.

Int Wound J 2019 Feb 17. Epub 2019 Feb 17.

Department of Vascular and Endovascular Surgery, Centre Hospitalier Sud Francilien, Paris, France.

Abnormal, persistent inflammation after bypass surgery could prevent healing of an ischaemic foot lesion. In 37 patients with peripheral arterial disease (PAD) (Rutherford Grade III Category 5) who underwent infrapopliteal vein graft and midfoot amputation, plasma levels of fibrinogen, C-reactive protein (CRP), interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), and matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) were determined preoperatively and during the follow up. Nine patients without clinical and Doppler evidence of arterial disease, who underwent post-traumatic midfoot primary amputation, were included in the experiment group, and 15 age-matched healthy volunteers served as control. Read More

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http://dx.doi.org/10.1111/iwj.13086DOI Listing
February 2019

Inhibition of endothelial Progenitor Cells Inhibition in the first 24 hours of an Acute Ischemic Cerebrovascular Event.

Isr Med Assoc J 2019 Feb;21(2):71-76

Department of Medicine, Padeh Medical Center, Poriya, Israel.

Background: Endothelial progenitor cells may have a role in ongoing endothelial repair. Impaired mobilization or depletion of these cells may contribute to progression of vascular disease. Our hypothesis was that endothelial progenitor cells would be suppressed in patients with acute cerebrovascular event based on our previous study that found severe endothelial dysfunction in those patients. Read More

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February 2019
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Mandatory public reporting of cardiac surgery outcomes: The 2003 to 2014 Massachusetts experience.

J Thorac Cardiovasc Surg 2018 Dec 31. Epub 2018 Dec 31.

Department of Health Care Policy, Harvard Medical School, Boston, Mass; T.H. Chan School of Public Health, Harvard University, Boston, Mass.

Objectives: Beginning in 2002, all 14 Massachusetts nonfederal cardiac surgery programs submitted Society of Thoracic Surgeons (STS) National Database data to the Massachusetts Data Analysis Center for mandatory state-based analysis and reporting, and to STS for nationally benchmarked analyses. We sought to determine whether longitudinal prevalences and trends in risk factors and observed and expected mortality differed between Massachusetts and the nation.

Methods: We analyzed 2003 to 2014 expected (STS predicted risk of operative [in-hospital + 30-day] mortality), observed, and risk-standardized isolated coronary artery bypass graft mortality using Massachusetts STS data (N = 39,400 cases) and national STS data (N = 1,815,234 cases). Read More

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http://dx.doi.org/10.1016/j.jtcvs.2018.12.072DOI Listing
December 2018

Unlikely association between Kawasaki disease and intracranial aneurysms: a prospective cohort study.

J Neurosurg Pediatr 2019 Feb 15:1-4. Epub 2019 Feb 15.

1Department of Neurosurgery, Division of Clinical Neurosciences.

OBJECTIVEKawasaki disease (KD) is a vasculitis that can cause aneurysm formation in coronary arteries and, more rarely, in peripheral arteries. A possible connection between KD and intracranial aneurysms is unclear. The purpose of this study was to determine if KD is associated with intracranial aneurysms. Read More

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http://dx.doi.org/10.3171/2018.11.PEDS18575DOI Listing
February 2019

Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial).

J Surg Res 2019 Feb 13;238:164-174. Epub 2019 Feb 13.

Division of Vascular and Endovascular Surgery, Department of Surgery, University of California, San Francisco, California. Electronic address:

Background: N-3 polyunsaturated fatty acid (PUFA) supplementation has been associated with reduced mortality and inflammation in patients with cardiovascular disease. There are limited data on the effects of n-3 PUFA supplementation in patients with peripheral artery disease (PAD).

Materials And Methods: The OMEGA-PAD II trial was a double-blinded, randomized, placebo-controlled trial to assess the effect of 3 mo of high-dose oral n-3 PUFA supplementation on inflammation, endothelial function, and walking ability in patients with PAD. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.038DOI Listing
February 2019

Perceptions of Canadian vascular surgeons toward pharmacologic risk reduction in patients with peripheral artery disease: 2018 update.

Ann Vasc Surg 2019 Feb 13. Epub 2019 Feb 13.

Division of Vascular Surgery, Li Ka Shing Knowledge Institute of St. Michael's Hospital, and University of Toronto, Toronto, ON, Canada; Department of Surgery, King Saud University, Riyadh, Kingdom of Saudi Arabia; King Saud University-Li Ka Shing Collaborative Research Program, Toronto, Ontario, Canada; and Riyadh, Kingdom of Saudi Arabia. Electronic address:

Background: Vascular surgeons have a central role in managing peripheral artery disease (PAD). This study assessed their knowledge, attitudes, and behaviours regarding pharmacologic risk reduction in PAD and results were compared to a similar 2004 survey conducted by our group.

Methods: An online questionnaire was administered to 161 active members of the Canadian Society for Vascular Surgery. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.11.034DOI Listing
February 2019

Gut microbiota-dependent CCR9+CD4+ T cells are altered in secondary progressive multiple sclerosis.

Brain 2019 Feb 15. Epub 2019 Feb 15.

Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, Japan.

The mechanism underlying the progression of relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis (SPMS), characterized by accumulating fixed disability, is yet to be fully understood. Although alterations in the gut microbiota have recently been highlighted in multiple sclerosis pathogenesis, the mechanism linking the altered gut environment with the remote CNS pathology remains unclear. Here, we analyse human CD4+ memory T cells expressing the gut-homing chemokine receptor CCR9 and found a reduced frequency of CCR9+ memory T cells in the peripheral blood of patients with SPMS relative to healthy controls. Read More

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http://dx.doi.org/10.1093/brain/awz012DOI Listing
February 2019

Validity and reliability of lower-limb pulse-wave velocity assessments using an oscillometric technique.

Exp Physiol 2019 Feb 16. Epub 2019 Feb 16.

Department of Exercise and Sport Science, University of North Carolina, Chapel Hill, USA.

New Findings: What is the central question of this study? There is growing interest on the effects of sedentarism on central and peripheral cardiovascular health. To permit further investigation, including in larger epidemiological studies, there is a need to identify arterial health assessment tools that are valid (accurate) and reliable (precise), yet practical. What is the main finding and its importance? Lower-limb vascular health (femoral-ankle pulse-wave velocity) can be determined in a supine position with accuracy and precision using an oscillometric-based device. Read More

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http://dx.doi.org/10.1113/EP087444DOI Listing
February 2019

Factors associated with readmission and mortality in adult patients with skin and soft tissue infections.

Int J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Clinical Microbiology Department, Son Llàtzer Hospital, Balearic Islands, Spain.

Background: Skin and soft tissue infections (SSTIs) are a common cause of consultation, and complicated cases require hospitalization. We describe factors that are related to readmission and/or mortality of hospitalized patients diagnosed with SSTIs.

Methods: Retrospective review of hospital-admitted patients with a diagnosis of cellulitis, abscess, hidradenitis, fasciitis, and Fournier's gangrene. Read More

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http://dx.doi.org/10.1111/ijd.14390DOI Listing
February 2019

Endocannabinoid Signalling in Atherosclerosis and Related Metabolic Complications.

Thromb Haemost 2019 Feb 15. Epub 2019 Feb 15.

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.

Endocannabinoids are a group of arachidonic acid-derived lipid mediators binding to cannabinoid receptors CB1 and CB2. An overactivity of the endocannabinoid system plays a pathophysiological role in the development of visceral obesity and insulin resistance. Moreover, elevated circulating endocannabinoid levels are also prevalent in atherosclerosis. Read More

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http://dx.doi.org/10.1055/s-0039-1678738DOI Listing
February 2019

Association between Drug Use and In-Hospital Outcomes after Infrainguinal Bypass for Peripheral Arterial Occlusive Disease.

Ann Vasc Surg 2019 Feb 12. Epub 2019 Feb 12.

Johns Hopkins Bayview Vascular and Endovascular Research Center, Baltimore, MD; Department of Surgery, University of California San Diego, La Jolla, CA. Electronic address:

Objective: Drug abuse may affect lower extremity vessels due to ischemia following intra-arterial injections, vasospasm, arterial and venous pseudoaneurysms, arteriovenous fistulae, vasculitis and complicated abscesses. Little is known about the outcomes of Lower Extremity Bypass (LEB) for peripheral arteries disease (PAD) in patients with a history of drug abuse disorder. The aim of this study is to evaluate the outcomes of LEB in this patient population. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.12.070DOI Listing
February 2019
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Assessment of the utility of a Vascular Early Warning System (VEWS) device in the assessment of peripheral arterial disease in patients with diabetes and incompressible vessels.

Ann Vasc Surg 2019 Feb 12. Epub 2019 Feb 12.

Leeds Vascular Institute, Leeds General Infirmary, Leeds, UK; Leeds Diabetes Limb Salvage Unit, St James' University Hospital, Leeds, UK; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.

Objectives: To assess the ability of a novel, automated CE marked vascular early warning system (VEWS) device to detect peripheral arterial disease in patients with incompressible ankle arteries and non-measurable ankle brachial pressure index (ABPI) secondary to diabetes.

Research Design And Methods: Recruited patients had diabetes, recent MRA evidence of PAD and incompressible vessels on ABPI. VEWS indices of each leg were automatically calculated by employing optical infrared and red sensors applied to the foot with readings obtained with the subject's leg both flat and elevated. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.11.033DOI Listing
February 2019

Hard-to-heal diabetic foot ulcers treated using negatively charged polystyrene microspheres: a prospective case series.

J Wound Care 2019 Feb;28(2):104-109

Diabetic Foot Unit, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.

Objective:: To describe the outcomes of a new product based on negatively charged polystyrene microspheres (NCM) technology, in non-responding diabetic foot ulcers (DFU).

Methods:: A clinical case series of patients with a hard-to-heal DFU treated with NCM were recruited between March and June 2017 in a specialised diabetic foot unit. DFUs were treated daily with NCM over four weeks, although the health professional could decide to continue NCM treatment in some patients. Read More

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http://www.magonlinelibrary.com/doi/10.12968/jowc.2019.28.2.
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http://dx.doi.org/10.12968/jowc.2019.28.2.104DOI Listing
February 2019
1 Read

Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third- or further-line treatment.

Cancer Biol Med 2018 Nov;15(4):443-451

Department of Pulmonary Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.

Objective: Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor, fibroblast growth factor receptor, platelet-derived growth factor receptor, c-Kit, and c-MET; therefore, it exhibits both antitumor and anti-angiogenetic activities. A phase III trial has shown that anlotinib improved progression-free survival (PFS) and overall survival (OS) in patients with advanced non-small cell lung cancer (NSCLC), who presented with progressive disease or intolerance after standard chemotherapy. This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment. Read More

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http://dx.doi.org/10.20892/j.issn.2095-3941.2018.0158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372914PMC
November 2018

Endovascular Treatment of the Superficial Femoral Artery: When Nothing Is Actually Quite Something.

J Am Coll Cardiol 2019 Feb;73(6):680-683

Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.12.009DOI Listing
February 2019

Drug-Eluting Stent Versus Drug-Coated Balloon Revascularization in Patients With Femoropopliteal Arterial Disease.

J Am Coll Cardiol 2019 Feb;73(6):667-679

Division of Angiology, Department of Internal Medicine, Neurology and Dermatology, University Hospital Leipzig, Leipzig, Germany. Electronic address:

Background: Randomized trials of drug-eluting stents (DES) and drug-coated balloons (DCB) for femoropopliteal interventions reported superior patency rates for both strategies compared to standard balloon angioplasty. To date, head-to-head comparisons are missing.

Objectives: The authors sought to compare DES versus DCB for femoropopliteal lesions through 36 months. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.11.039DOI Listing
February 2019

CHADS₂, CHA₂DS₂ASc, and New ABCD Scores Predict the Risk of Peripheral Arterial Disease in Patients with Sleep Apnea.

J Clin Med 2019 Feb 5;8(2). Epub 2019 Feb 5.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

The association between sleep apnea (SA) and peripheral artery disease (PAD) remains debatable, and there is no clinical tool to predict incident PAD in SA patients. The CHADS₂ score has been found useful in predicting PAD risk. This study was designed to investigate the association between these diseases and the usefulness of CHADS₂ and CHA₂DS₂ASc scores in predicting subsequent PAD in SA patients. Read More

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http://dx.doi.org/10.3390/jcm8020188DOI Listing
February 2019

Spinal cord watershed infarction: Novel findings on magnetic resonance imaging.

Clin Imaging 2019 Jan 31;55:71-75. Epub 2019 Jan 31.

Department of Radiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32611, USA. Electronic address:

Spinal cord watershed ischemia is a rare phenomenon often associated with cardiac arrest, prolonged hypotension, and atherosclerotic disease. It can manifest as central necrosis with peripheral sparing in the transverse axis, and central lesion with rostral and caudal sparing in the longitudinal axis. Few reports provide detailed imaging findings of spinal cord watershed ischemia lesions. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.01.023DOI Listing
January 2019

Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease

Turk J Med Sci 2019 Feb 11;49(1):327-335. Epub 2019 Feb 11.

Background/aim: Fetuin-A, a circulating inhibitor of calcification, is a marker of inflammatory-nutritional state. We evaluated the association between serum fetuin-A levels and vascular calcification, intima-media thickness, and nutritional and inflammatory markers in different stages of chronic kidney disease (CKD).

Materials And Methods: CKD patients were sampled for calcium-phosphate parameters and nutritional and inflammatory markers [highly sensitive C-reactive protein (hs-CRP)], and serum fetuin-A levels. Read More

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http://dx.doi.org/10.3906/sag-1809-43DOI Listing
February 2019
1 Read

[The effectiveness of the integrated approach to the treatment of chronic prostatitis, including in patients with benign prostatic hyperplasia].

Urologiia 2018 Oct(4):81-87

I.P. Pavlov Ryazan State Medical University of Minzdrav of Russia, Ryazan, Russia.

Introduction: Concurrent chronic prostatitis (CP) plays an important role in the pathogenesis and progression of benign prostatic hyperplasia (BPH), increasing the severity of lower urinary tract symptoms (LUTS), lowering the quality of life, and increasing the risk of acute urinary retention. However, in the management of patients with BPH, the role of CP is not always taken into account.

Aim: To evaluate the effectiveness of integrated management of patients with CP and patients with co-occurring BPH and CP using a physiotherapeutic device Mavit for the treatment of inflammatory diseases of the prostate. Read More

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October 2018
5 Reads

Clinical Features and Outcomes of Peripheral Vascular Disease Patients Receiving Red Blood Cell Transfusions.

Cureus 2018 Dec 4;10(12):e3682. Epub 2018 Dec 4.

Emergency Medicine, Charleston Area Medical Center, Charleston, USA.

Background Peripheral vascular disease (PVD) patients are commonly transfused with red blood cells (RBC) due to their inability to compensate for anemia and blood loss. Anemias, as well as allogeneic transfusions, have been demonstrated as independent risk factors for increased mortality and morbidity following cardiovascular procedures. The relationships between anemia, transfusion, and adverse outcomes in PVD patients remain unascertained and understudied. Read More

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http://dx.doi.org/10.7759/cureus.3682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367124PMC
December 2018

Sex-dependent differences in central artery haemodynamics in normal and fibulin-5 deficient mice: implications for ageing.

Proc Math Phys Eng Sci 2019 Jan 9;475(2221):20180076. Epub 2019 Jan 9.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.

Mouse models provide unique opportunities to study vascular disease, but they demand increased experimental and computational resolution. We describe a workflow for combining and biomechanical data to build mouse-specific computational models of the central vasculature including regional variations in biaxial wall stiffness, thickness and perivascular support. These fluid-solid interaction models are informed by micro-computed tomography imaging and ultrasound and pressure measurements, and include mouse-specific inflow and outflow boundary conditions. Read More

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http://dx.doi.org/10.1098/rspa.2018.0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364598PMC
January 2019

Novel Antiplatelet Therapies for Atherothrombotic Diseases.

Arterioscler Thromb Vasc Biol 2019 Feb 14:ATVBAHA118310955. Epub 2019 Feb 14.

From the Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, MA.

Antiplatelet therapies are an essential tool to reduce the risk of developing clinically apparent atherothrombotic disease and are a mainstay in the therapy of patients who have established cardiovascular, cerebrovascular, and peripheral artery disease. Strategies to intensify antiplatelet regimens are limited by concomitant increases in clinically significant bleeding. The development of novel antiplatelet therapies targeting additional receptor and signaling pathways, with a focus on maintaining antiplatelet efficacy while preserving hemostasis, hold tremendous potential to improve outcomes among patients with atherothrombotic diseases. Read More

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.310955
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http://dx.doi.org/10.1161/ATVBAHA.118.310955DOI Listing
February 2019
2 Reads

Evaluation of vascular pain in patients with colorectal cancer receiving peripheral venous chemotherapy with or without oxaliplatin.

Sci Rep 2019 Feb 12;9(1):1819. Epub 2019 Feb 12.

Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Nanakuma 7-45-1, Jonan-ku, Fukuoka, 814-0180, Japan.

Oxaliplatin is a key chemotherapy drug in patients with colorectal cancer. Administration of oxaliplatin via a peripheral vein often causes vascular pain. However, no studies have evaluated vascular pain in patients with colorectal cancer in relation to peripheral venous administration of chemotherapy with or without oxaliplatin. Read More

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http://dx.doi.org/10.1038/s41598-018-37966-wDOI Listing
February 2019

Early risk assessment of circulating endothelial progenitor cells and plasma stromal cell-derived factor-1 for nondisabling ischemic cerebrovascular events.

BMC Neurol 2019 Feb 12;19(1):22. Epub 2019 Feb 12.

Department of Neurology, Second Peoples Hospital of Chengdu, Chengdu, 610000, Sichuan Province, China.

Background: Endothelial progenitor cells (EPCs) play an important role in ischemic stroke. However, there are few studies on the relationship between EPC and nondisabling ischemic cerebrovascular events. Our aim was to investigate the association of EPCs and SDF-1 (serum stromal cell-derived factor-1) with NICE (nondisabling ischemic cerebrovascular events). Read More

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http://dx.doi.org/10.1186/s12883-019-1250-5DOI Listing
February 2019

Glycocalyx Breakdown is Associated with Severe Disease and Fatal Outcome in Plasmodium falciparum Malaria.

Clin Infect Dis 2019 Feb 12. Epub 2019 Feb 12.

Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia.

Background: Interactions between the endothelium and infected erythrocytes, microvascular dysfunction and parasite sequestration play major roles in the pathogenesis of severe falciparum malaria. The glycocalyx is a carbohydrate-rich layer lining the endothelium mediating NO production and vascular homeostasis. The role of the glycocalyx in falciparum malaria and the association with disease severity is not known. Read More

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http://dx.doi.org/10.1093/cid/ciz038DOI Listing
February 2019
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Four-Limb Blood Pressure Measurement with an Oscillometric Device: a Tool for Diagnosing Peripheral Vascular Disease.

Curr Hypertens Rep 2019 Feb 12;21(2):15. Epub 2019 Feb 12.

Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, 330006, NO 1 Mingde Road, Nanchang, Jiangxi, China.

Purpose Of Review: Traditionally, the term peripheral vascular disease (PAD) is restricted to the occlusive arterial disease in the leg, but now, the connotation of PAD is more widespread as it encompasses all extracoronary and extracerebral vascular disease. The incidence of PAD is increasing worldwide; therefore, it is necessary to diagnose PAD at an early stage.

Recent Findings: Oscillometric BP device is widely used for four-limb measurement in clinical practice and provides several parameters for evaluating inter-limb BP difference, such as ankle-brachial index (OS-ABI), inter-arm BP differences (IAD), and inter-ankle BP difference (IAND). Read More

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http://dx.doi.org/10.1007/s11906-019-0917-zDOI Listing
February 2019

Accelerated peripheral vascular aging in pseudoxanthoma elasticum - proof of concept for arterial calcification-induced cardiovascular disease.

Aging (Albany NY) 2019 Feb;11(3):1062-1064

Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.18632/aging/101821DOI Listing
February 2019

Hospital Incidence, Treatment, and In Hospital Mortality Following Open and Endovascular Surgery for Thoraco-abdominal Aortic Aneurysms in Germany from 2005 to 2014: Secondary Data Analysis of the Nationwide German DRG Microdata.

Eur J Vasc Endovasc Surg 2019 Feb 7. Epub 2019 Feb 7.

Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany. Electronic address:

Objective: Hospital incidence, treatment modality, and in hospital mortality after surgery are reported for thoraco-abdominal aortic aneurysms (TAAAs) treated by endovascular or open means in Germany from 2005 to 2014.

Methods: Data were extracted from diagnosis related group statistics from the German Federal Statistical Office. All inpatient cases with a diagnosis of ruptured and non-ruptured TAAA (ICD-10 I71. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10785884183080
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http://dx.doi.org/10.1016/j.ejvs.2018.10.030DOI Listing
February 2019
4 Reads

The longitudinal association between natural outdoor environments and mortality in 9218 older men from Perth, Western Australia.

Environ Int 2019 Feb 8;125:430-436. Epub 2019 Feb 8.

School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia.

Background/aim: Natural outdoor environments may mitigate harmful environmental factors associated with city living. We studied the longitudinal relationship between natural ('green and blue') outdoor environments and mortality in a cohort of older men residing in Perth, Western Australia.

Methods: We studied a cohort of 9218 men aged 65 years and older from the Health In Men Study. Read More

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http://dx.doi.org/10.1016/j.envint.2019.01.075DOI Listing
February 2019

Plasticity of the Maternal Vasculature During Pregnancy.

Annu Rev Physiol 2019 Feb;81:89-111

Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Arcavacata di Rende (CS), Italy.

Maternal cardiovascular changes during pregnancy include an expansion of plasma volume, increased cardiac output, decreased peripheral resistance, and increased uteroplacental blood flow. These adaptations facilitate the progressive increase in uteroplacental perfusion that is required for normal fetal growth and development, prevent the development of hypertension, and provide a reserve of blood in anticipation of the significant blood loss associated with parturition. Each woman's genotype and phenotype determine her ability to adapt in response to molecular signals that emanate from the fetoplacental unit. Read More

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http://dx.doi.org/10.1146/annurev-physiol-020518-114435DOI Listing
February 2019
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Perforated appendicitis in the setting of a massive ventral hernia, morbid obesity, and multiple severe comorbidities: challenges in acute management.

Trauma Surg Acute Care Open 2019 24;4(1):e000243. Epub 2019 Jan 24.

Division of General Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

A 57-year-old woman with morbid obesity (body mass index [BMI] of 43), systemic lupus on steroids, type 2 insulin-dependent diabetes, peripheral vascular disease, unprovoked pulmonary embolism on rivaroxaban, and hypertension presented with 3 days of worsening abdominal pain and nausea. She had an extensive surgical history including a cesarean section, multiple laparotomies for small bowel obstructions (one complicated by bowel perforation requiring resection), and a double-barrelled ileostomy, which had been since reversed. As a result, she had a massive incisional hernia (figure 1). Read More

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http://dx.doi.org/10.1136/tsaco-2018-000243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347851PMC
January 2019
1 Read

Non-invasive vascular screening test to diagnose peripheral vascular disease.

Ann Transl Med 2018 Dec;6(Suppl 2):S108

Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.21037/atm.2018.11.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330627PMC
December 2018

Acute iliac arterial thrombosis during laparoscopic abdominoperineal resection.

J Surg Case Rep 2019 Feb 5;2019(2):rjz020. Epub 2019 Feb 5.

Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Background: Acute iliac arterial thrombosis during surgery is very rare complication. There were few reports on this complication relative to gastroenterological surgery, and the risk has not been recognized.

Case Presentation: A 70-year-old man, diagnosed with a rectal cancer (adenocarcinoma of rectum) with known history heavy cigarette smoking with no known history of peripheral vascular disease underwent a laparoscopic abdominoperineal resection. Read More

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http://dx.doi.org/10.1093/jscr/rjz020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362890PMC
February 2019
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Thirty-day readmission after endovascular or surgical revascularization for chronic mesenteric ischemia: Insights from the Nationwide Readmissions Database.

Vasc Med 2019 Feb 10:1358863X18816816. Epub 2019 Feb 10.

1 Cardiovascular Institute, Warren Alpert Medical School of Brown University, Providence, RI, USA.

There are limited contemporary data on readmission after revascularization for chronic mesenteric ischemia (CMI). This study aimed to determine the rates, reasons, predictors, and costs of 30-day readmission after endovascular or surgical revascularization for CMI. Patients with CMI discharged after endovascular or surgical revascularization during 2013 to 2014 were identified from the Nationwide Readmissions Database. Read More

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http://dx.doi.org/10.1177/1358863X18816816DOI Listing
February 2019
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Pentoxifylline ameliorates chronic stress/high-fat diet-induced vascular wall disease: the role of circulating endothelial progenitor cells.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 9. Epub 2019 Feb 9.

Department of Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Depression and cardiovascular disease (CVD) are two faces of one coin. A pro-inflammatory state was previously suggested in the pathology of both diseases. We investigated the effect of chronic administration (2 weeks) of imipramine (20 mg/kg/day) and pentoxifylline (50 mg/kg/day) on behavioral, aortic histological abnormalities, and level of circulating endothelial progenitor cells (CEPCs) in peripheral blood of male Wistar rats exposed to chronic mild stress (CMS) and high-fat diet. Read More

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http://link.springer.com/10.1007/s00210-019-01627-0
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http://dx.doi.org/10.1007/s00210-019-01627-0DOI Listing
February 2019
6 Reads
2.471 Impact Factor

Association between peripheral artery disease and major adverse cardiovascular events in patients with acute coronary syndrome: findings from the Gulf COAST registry.

Med Princ Pract 2019 Feb 10. Epub 2019 Feb 10.

Objective: To evaluate the association between peripheral artery disease (PAD) and major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS) in the Arabian Gulf.

Methods: Data was analyzed from 4044 consecutive patients diagnosed with ACS admitted to 29 hospitals in four Arabian Gulf countries from January 2012 to January 2013. PAD was defined as any of the following: claudication, amputation for arterial vascular insufficiency, vascular reconstruction, bypass surgery, or percutaneous intervention in the extremities, documented aortic aneurysm or ankle brachial index of < 0. Read More

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http://dx.doi.org/10.1159/000497790DOI Listing
February 2019
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Leptinemia is Associated With Peripheral Artery Disease.

J Surg Res 2019 Feb 6;238:48-56. Epub 2019 Feb 6.

Department of Surgery, University of California, San Francisco, San Francisco, California. Electronic address:

Background: Leptin, adiponectin, and resistin are in a class of hormones called adipokines that are produced by adipocytes and have been implicated in the causal pathway of atherosclerosis. We examined the association between adipokine levels and peripheral artery disease (PAD), hypothesizing that after adjusting for fat mass, leptin and resistin would be higher, whereas adiponectin would be lower, in patients with PAD.

Methods: A cross-sectional sample of 179 predominately male (97%) vascular surgery outpatients was recruited from the San Francisco Veterans Affairs Medical Center (SFVAMC). Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.023DOI Listing
February 2019

Hospital Discharge Teaching for Patients with Peripheral Vascular Disease.

Crit Care Nurs Clin North Am 2019 Mar 22;31(1):91-95. Epub 2018 Dec 22.

Louisiana State University Health New Orleans, School of Nursing, 1900 Gravier Street, New Orleans, LA 70112, USA.

Peripheral disease affects both arteries and veins and encompasses pathophysiologic conditions that affect arterial, venous, and lymphatic circulations. This article discusses disorders of peripheral vascular disease (PVD) that affect the lower extremity. PVD is an obstruction in the arteries known as arteriosclerosis obliterans, a condition that manifests from insufficient tissue perfusion that results in hardening of the arteries. Read More

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http://dx.doi.org/10.1016/j.cnc.2018.11.003DOI Listing

Risk factors for critical limb ischemia in patients undergoing femoral cannulation for venoarterial extracorporeal membrane oxygenation: Is distal limb perfusion a mandatory approach?

Perfusion 2019 Feb 8:267659119827231. Epub 2019 Feb 8.

1 Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.

Background:: Venoarterial extracorporeal membrane oxygenation support is a well-established tool in the care of severe refractory cardiac and respiratory failure. The application of this support may serve as a bridge to transplant, recovery or to implantation of a ventricular assist device. Venoarterial extracorporeal membrane oxygenation support can be administered through an open surgical access via the common femoral or axillary artery or a percutaneous approach using Seldinger technique. Read More

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http://dx.doi.org/10.1177/0267659119827231DOI Listing
February 2019
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Rehabilitative Exercise Reduced the Impact of Peripheral Artery Disease on Vascular Outcomes in Elderly Patients with Claudication: A Three-Year Single Center Retrospective Study.

J Clin Med 2019 Feb 7;8(2). Epub 2019 Feb 7.

Department of Nursing, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofía University Hospital, 14004 Cordoba, Spain.

The study retrospectively evaluated the association between rehabilitative outcomes and risk of peripheral revascularizations in elderly peripheral artery disease (PAD) patients with claudication. Eight-hundred thirty-five patients were enrolled. Ankle-brachial index (ABI) and maximal walking speed (S) were measured at baseline and at discharge from a structured home-based rehabilitation program. Read More

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http://dx.doi.org/10.3390/jcm8020210DOI Listing
February 2019

Evaluation of materials used for vascular anastomoses using shear wave elastography.

Phys Med Biol 2019 Feb 8. Epub 2019 Feb 8.

Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minnesota, 55905, UNITED STATES.

Cardiovascular disease is the leading cause of mortality in the United States. Peripheral artery disease (PAD) affects a substantial portion of the elderly population (> 70 years). PAD can be symptomatic or asymptomatic, and treatment is directed towards improving functional vessel patency and limb salvage. Read More

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http://dx.doi.org/10.1088/1361-6560/ab055cDOI Listing
February 2019