84,721 results match your criteria Peripheral Vascular Disease

The illness and death of King George VI of England: the pathologists' reassessment.

Cardiovasc Pathol 2021 Jun 8;53:107340. Epub 2021 Jun 8.

Department of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health and Science Center at Houston, Houston, Texas 77030, USA.

The illness and death of King George VI has received renewed attention based on the events portrayed in the Netflix blockbuster series, The Crown. The King, a heavy smoker, underwent a left total pneumonectomy in September 1951 for what euphemistically was called "structural abnormalities" of his left lung, but what in reality was a carcinoma. His physicians withheld this diagnosis from him, the public, and the medical profession. Read More

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Novel Approaches to Restore Pancreatic Beta-Cell Mass and Function.

Handb Exp Pharmacol 2021 Jun 11. Epub 2021 Jun 11.

Institute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich-Heine-University, Düsseldorf, Germany.

Beta-cell dysfunction and beta-cell death are critical events in the development of type 2 diabetes mellitus (T2DM). Therefore, the goals of modern T2DM management have shifted from merely restoring normoglycemia to maintaining or regenerating beta-cell mass and function. In this review we summarize current and novel approaches to achieve these goals, ranging from lifestyle interventions to N-methyl-D-aspartate receptor (NMDAR) antagonism, and discuss the mechanisms underlying their effects on beta-cell physiology and glycemic control. Read More

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Screening for atrial fibrillation in high-risk nursing home residents.

Heart Rhythm O2 2020 Apr 27;1(1):10-13. Epub 2020 Apr 27.

Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York.

Background: Various methods have been implemented for screening of patients for atrial fibrillation (AF), but the yield has generally been low. Targeting high-risk patients may improve detection of asymptomatic AF, which could be of value if appropriate treatment could be initiated before a potential thromboembolic event.

Objective: The purpose of this study was to test screening of high-risk nursing home residents having ≥2 risk factors for AF and no previous history of AF using a smartphone-based electrocardiographic (ECG) monitoring device to determine whether it is an accurate, easy-to-use method of screening for asymptomatic AF. Read More

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Inter-rater Reliability of a 13-Category Arterial Doppler Waveform Classification and Practice of French Vascular Physicians.

Front Cardiovasc Med 2021 25;8:640838. Epub 2021 May 25.

Université de Rennes 1, INSERM CIC 1414, Rennes, France.

Arterial Doppler Ultrasound waveform (DW) analysis allows the detection and evaluation of lower extremity peripheral artery disease. The high heterogeneity of the reported description of DW is reduced by the use of classification. However, the reliability of these classifications is either unknown or low to moderate and practices of vascular caregivers regarding the use of these classifications remain unknown. Read More

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Novel Immune Cell Subsets Exhibit Different Associations With Vascular Outcomes in Chronic Kidney Disease Patients-Identifying Potential Biomarkers.

Front Med (Lausanne) 2021 25;8:618286. Epub 2021 May 25.

Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Oviedo, Spain.

Alterations in novel immune cell subsets, such as angiogenic T cells (Tang), senescent T cells (CD4CD28), and monocyte subsets are associated with impaired vascular homeostasis in several inflammatory conditions. However, mediators underlying vascular deterioration in chronic kidney disease (CKD) are poorly characterized. This study assessed their role in the vascular deterioration of CKD using a broad spectrum of surrogate markers ranging from altered functionality to overt calcification. Read More

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Successful removal of a Life-threatening PE using the INARI flow triever device.

Radiol Case Rep 2021 Jul 25;16(7):1878-1881. Epub 2021 May 25.

McClow, Clark and Berk Radiologists, Jacksonville, Florida.

The authors report a case of a 75-year-old male with pulmonary embolism (PE) successfully treated using the INARI FlowTriever System, a mechanical thrombectomy device. Imaging confirmed deep vein thrombosis and PE presented after two days of left lower extremity (LLE) pain and dyspnea on exertion with history of peripheral vascular disease, coronary artery disease, insulin dependent diabetes mellitus, hyperlipidemia and LLE percutaneous coronary intervention with coronary stent placement. PE treatment with single session clot burden reduction resulted in immediate improvement in oxygenation and echocardiogram confirmed relief of right heart strain. Read More

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A Predictive Model for Progression of Chronic Kidney Disease to Kidney Failure Using a Large Administrative Claims Database.

Clinicoecon Outcomes Res 2021 4;13:475-486. Epub 2021 Jun 4.

Managed Care Health Outcomes, Vifor Pharma, Inc., Redwood City, CA, USA.

Background: To create an appropriate chronic kidney disease (CKD) management program, we developed a predictive model to identify patients in a large administrative claims database with CKD stages 3 or 4 who were at high risk for progression to kidney failure.

Methods: The predictive model was developed and validated utilizing a subset of patients with CKD stages 3 or 4 derived from a large Aetna claims database. The study spanned 36 months, comprised of a 12-month (2015) baseline period and a 24-month (2016-2017) prediction period. Read More

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Distribution of Peripheral Arterial Disease in Patients Undergoing Endovascular Revascularization for Chronic Limb Threatening Ischaemia: Insights from the Vascular Quality Initiative in Singapore.

Vasc Specialist Int 2021 Jun 11;37:13. Epub 2021 Jun 11.

Department of Vascular Surgery, Singapore General Hospital, Singapore.

This study aimed to examine the distribution of lower limb atherosclerotic lesions in a multi-ethnic Asian cohort with chronic limb threatening ischemia (CLTI) from Singapore. The Society for Vascular Surgery Vascular Quality Initiative registry database was used to identify 265 CLTI patients who underwent percutaneous angioplasty between June 2019 and December 2019, of whom 171 (64.5%) were male, and the mean age was 67. Read More

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Atherectomy Combined with Balloon Angioplasty versus Balloon Angioplasty Alone for de Novo Femoropopliteal Arterial Diseases: A Systematic Review and Meta-analysis of Randomised Controlled Trials.

Eur J Vasc Endovasc Surg 2021 Jun 7. Epub 2021 Jun 7.

Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University, School of Medicine, Shanghai, China; Vascular Centre of Shanghai JiaoTong University, Shanghai, China. Electronic address:

Objective: The efficacy and cost effectiveness of atherectomy for femoropopliteal (FP) arterial diseases have not been determined yet. A systematic review and meta-analysis were performed to compare the efficacy and safety between atherectomy combined with balloon angioplasty (BA) and BA alone for patients with de novo FP steno-occlusive lesions.

Methods: The Cochrane Library, Medline, and Embase were used to search for studies evaluating outcomes of atherectomy combined with BA compared with BA alone in FP arterial diseases from inception to July 2020. Read More

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The use of near-infrared spectroscopy in the diagnosis of peripheral artery disease: A systematic review.

Vascular 2021 Jun 10:17085381211025174. Epub 2021 Jun 10.

70309Kaunas University of Technology, Kaunas, Lithuania.

Background: Peripheral arterial disease is a stenosis or occlusion of peripheral arteries that results in compromised blood flow and muscle ischemia. The available diagnostic methods are mostly used to measure and visualize blood flow and are not useful in the evaluation of perfusion, especially in diabetic patients, which is now considered to be a research priority by most of the vascular societies around the world as this is still a relatively poorly studied phenomenon.

Objective: The aim of this review is to explore the clinical significance of muscle tissue oxygenation monitoring in lower-extremity peripheral artery disease diagnosis using the near-infrared spectroscopy method. Read More

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Prognostic value of C-reactive protein to albumin ratio for long-term outcomes of patients with peripheral arterial disease underwent endovascular treatment.

Vascular 2021 Jun 10:17085381211025172. Epub 2021 Jun 10.

Department of Cardiology, Medical Faculty, M.D. Kafkas University, Kars, Turkey.

Background: Peripheral artery disease (PAD) is part of the systemic atherosclerotic process that is highly associated with cardiovascular diseases. Despite successful endovascular treatment (EVT) strategies, mortality and morbidity rates still remain higher in PAD patients. C-reactive protein (CRP) and albumin are biomarkers of inflammation and malnutrition that play key roles in the progression of peripheral arterial disease. Read More

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Leveraging Machine Learning and Artificial Intelligence to Improve Peripheral Artery Disease Detection, Treatment, and Outcomes.

Circ Res 2021 Jun 10;128(12):1833-1850. Epub 2021 Jun 10.

Department of Surgery, Division of Vascular Surgery (A.M.F., F.D., N.J.L., E.G.R.), Stanford University School of Medicine, CA.

Peripheral artery disease is an atherosclerotic disorder which, when present, portends poor patient outcomes. Low diagnosis rates perpetuate poor management, leading to limb loss and excess rates of cardiovascular morbidity and death. Machine learning algorithms and artificially intelligent systems have shown great promise in application to many areas in health care, such as accurately detecting disease, predicting patient outcomes, and automating image interpretation. Read More

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Contemporary Medical Management of Peripheral Artery Disease.

Circ Res 2021 Jun 10;128(12):1868-1884. Epub 2021 Jun 10.

Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (M.A.C.).

Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis. Modifiable risk factors including cigarette smoking, dyslipidemia, diabetes, poor diet quality, obesity, and physical inactivity, along with underlying genetic factors contribute to lower extremity atherosclerosis. Patients with PAD often have coexistent coronary or cerebrovascular disease, and increased likelihood of major adverse cardiovascular events, including myocardial infarction, stroke and cardiovascular death. Read More

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Epidemiology of Peripheral Artery Disease and Polyvascular Disease.

Circ Res 2021 Jun 10;128(12):1818-1832. Epub 2021 Jun 10.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (K.M.).

Atherosclerotic lower extremity peripheral artery disease (PAD) is increasingly recognized as an important cause of cardiovascular morbidity and mortality that affects >230 million people worldwide. Traditional cardiovascular risk factors, including advanced age, smoking, and diabetes, are strongly linked to an increase risk of PAD. Although PAD has been historically underappreciated compared with coronary artery disease and stroke, greater attention on PAD in recent years has led to important new epidemiological insights in the areas of thrombosis, inflammation, dyslipidemia, and microvascular disease. Read More

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Genetic Determinants of Peripheral Artery Disease.

Circ Res 2021 Jun 10;128(12):1805-1817. Epub 2021 Jun 10.

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (S.M.D.).

Peripheral artery disease-atherosclerosis of the abdominal aorta and lower extremity vascular bed-is a complex disease with both environmental and genetic determinants. Unmitigated disease is associated with major functional decline and can lead to chronic limb-threatening ischemia, amputation, and increased mortality. Over the last 10 years, major advances have been made in identifying the genetic basis of this common, complex disease. Read More

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Advances in Revascularization for Peripheral Artery Disease: Revascularization in PAD.

Circ Res 2021 Jun 10;128(12):1885-1912. Epub 2021 Jun 10.

Division of Vascular and Endovascular Surgery, University of California, San Francisco (P.A.S., M.S.C.).

Effective revascularization of the patient with peripheral artery disease is about more than the procedure. The approach to the patient with symptom-limiting intermittent claudication or limb-threatening ischemia begins with understanding the population at risk and variation in clinical presentation. The urgency of revascularization varies significantly by presentation; from patients with intermittent claudication who should undergo structured exercise rehabilitation before revascularization (if needed) to those with acute limb ischemia, a medical emergency, who require revascularization within hours. Read More

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Peripheral Vascular Disease in 2021.

Circ Res 2021 Jun 10;128(12):1803-1804. Epub 2021 Jun 10.

Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, MA (N.M.H.).

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Racial and Ethnic Disparities in Peripheral Artery Disease.

Circ Res 2021 Jun 10;128(12):1913-1926. Epub 2021 Jun 10.

Division of Cardiovascular Medicine, Harrington Heart and Vascular Institute, University Hospitals, Cleveland, OH (E.L.H., K.W.S.).

Peripheral artery disease is an obstructive, atherosclerotic disease of the lower extremities causing significant morbidity and mortality. Black Americans are disproportionately affected by this disease while they are also less likely to be diagnosed and promptly treated. The consequences of this disparity can be grim as Black Americans bear the burden of lower extremity amputation resulting from severe peripheral artery disease. Read More

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Bench-to-Bedside in Vascular Medicine: Optimizing the Translational Pipeline for Patients With Peripheral Artery Disease.

Circ Res 2021 Jun 10;128(12):1927-1943. Epub 2021 Jun 10.

Division of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, CA (T.A., N.J.L.).

Peripheral arterial disease is a growing worldwide problem with a wide spectrum of clinical severity and is projected to consume >$21 billion per year in the United States alone. While vascular researchers have brought several therapies to the clinic in recent years, few of these approaches have leveraged advances in high-throughput discovery screens, novel translational models, or innovative trial designs. In the following review, we discuss recent advances in unbiased genomics and broader omics technology platforms, along with preclinical vascular models designed to enhance our understanding of disease pathobiology and prioritize targets for additional investigation. Read More

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New Directions in Therapeutic Angiogenesis and Arteriogenesis in Peripheral Arterial Disease.

Circ Res 2021 Jun 10;128(12):1944-1957. Epub 2021 Jun 10.

Department of Cardiovascular Sciences, Houston Methodist Research Institute, TX (J.P.C.).

The prevalence of peripheral arterial disease (PAD) in the United States exceeds 10 million people, and PAD is a significant cause of morbidity and mortality across the globe. PAD is typically caused by atherosclerotic obstructions in the large arteries to the leg(s). The most common clinical consequences of PAD include pain on walking (claudication), impaired functional capacity, pain at rest, and loss of tissue integrity in the distal limbs that may lead to lower extremity amputation. Read More

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Impact of Alcohol Use Disorder on Stroke Risk in Geriatric Patients with Prediabetes: A Nationwide Analysis.

Int J Clin Pract 2021 Jun 9:e14477. Epub 2021 Jun 9.

Division of Cardiology, Atlanta VA Medical Center, Decatur, GA, USA.

Background: With rising trends of prediabetes in the geriatric population, we aim to assess the impact of alcohol use disorder (AUD) on the outcomes of patients with prediabetes.

Methods: Hospitalizations among the patients (≥65 years) with prediabetes were identified with a diagnosis of AUD and in-hospital stroke using the National Inpatient Sample database (2007-2014). We compared demographics, comorbidities, all-cause mortality, stroke rate, and resource utilization in the elderly prediabetes patients with vs. Read More

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Adaptive immune system in pulmonary sarcoidosis - comparison of peripheral and alveolar biomarkers.

Clin Exp Immunol 2021 Jun 9. Epub 2021 Jun 9.

Respiratory Diseases and Lung Transplantation, Department of Medical and Surgical Sciences & Neurosciences, Siena University Hospital, Siena, 53100, Italy.

Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Recent research has focused on the role of autoimmunity in its development and progression. This study aimed to determine and define disturbance and distribution of T- and B-cell subsets in the alveolar and peripheral compartments. Read More

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Anesthetic Considerations for Endovascular Neurologic, Vascular, and Cardiac Procedures.

Adv Anesth 2020 Dec 18;38:63-95. Epub 2020 Sep 18.

Department of Anesthesiology, University of Virginia Health System, PO Box 800710, Charlottesville, VA 22908, USA. Electronic address:

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December 2020

Diffusion tensor imaging indices of acute muscle damage are augmented after exercise in peripheral arterial disease.

Eur J Appl Physiol 2021 Jun 9. Epub 2021 Jun 9.

Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, USA.

Purpose: Although it is known that peripheral arterial disease (PAD) is associated with chronic myopathies, the acute muscular responses to exercise in this population are less clear. This study used diffusion tensor imaging (DTI) to compare acute exercise-related muscle damage between PAD patients and healthy controls.

Methods: Eight PAD patients and seven healthy controls performed graded plantar flexion in the bore of a 3T MRI scanner. Read More

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Mortality Rates After Paclitaxel-Coated Device Use in Patients With Occlusive Femoropopliteal Disease: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

J Endovasc Ther 2021 Jun 9:15266028211023505. Epub 2021 Jun 9.

Department of Surgery, Prince of Wales Hospital, Sydney, New South Wales, Australia.

Purpose: A late increased mortality risk has been reported in a summary level meta-analysis of patients with femoropopliteal artery occlusive disease treated with paclitaxel-coated angioplasty balloons and stents. However, at the longer follow up timepoints that analysis was limited by small trial numbers and few participants. The aim of this study was to report an updated summary level risk of all-cause mortality after treatment with paclitaxel-coated devices in that same patient group. Read More

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Exploring prevalence of wound infections and related patient characteristics in homecare using natural language processing.

Int Wound J 2021 Jun 9. Epub 2021 Jun 9.

School of Nursing, Columbia University, New York City, New York, USA.

We aimed to create and validate a natural language processing algorithm to extract wound infection-related information from nursing notes. We also estimated wound infection prevalence in homecare settings and described related patient characteristics. In this retrospective cohort study, a natural language processing algorithm was developed and validated against a gold standard testing set. Read More

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Using Patient-Reported Outcomes toAssess Healthcare Quality: Toward Better Measurement of Patient-Centered Care in Cardiovascular Disease.

Methodist Debakey Cardiovasc J 2021 Apr;17(1):e1-e9

Saint Luke's Mid America Heart Institute, University of Missouri Kansas City,Kansas City, Missouri.

Patient-reported outcomes (PROs) are elicited directly from patients so they can describe their overall health status, including their symptoms, function, and quality of life. While commonly used as end points in clinical trials, PROs can play an important role in routine clinical care, population health management, and as a means for quantifying the quality of patient care. In this review, we propose that PROs be used to improve patient-centered care in the treatment of cardiovascular diseases given their importance to patients and society and their ability to improve doctor- provider communication. Read More

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Relationship between Vitamin D Deficiency, Albuminuria, Peripheral Artery Disease and 5-year Mortality in Chronic Kidney Disease.

Yasemin Özgür

J Coll Physicians Surg Pak 2021 Jun;30(6):644-650

Department of Internal Medicine, Kartal Dr Lutfi Kırdar City Hospital, İstanbul, Turkey.

Objective: To investigate the effects of vitamin D deficiency, albuminuria and peripheral artery disease (PAD) relationships, on 5-year mortality in patients with chronic kidney disease (CKD) .

Methodology: Observational study.

Place And Duration Of Study: Department of Internal Medicine, Kartal Dr Lutfi Kırdar City Hospital, İstanbul, Turkey, from August 2015 to August 2020. Read More

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Can Paclitaxel Coated Balloons Have a Deep Impact on Critical Limb Ischemia?

JACC Basic Transl Sci 2021 May 24;6(5):428-430. Epub 2021 May 24.

Center for Interventional Vascular Therapy, Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.

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Heart failure due to primary hypothyroidism. Case report and review

Rev Med Inst Mex Seguro Soc 2020 ;58(2):206-211

Hospital Militar Central, Unidad de Insuficiencia Cardiaca, Servicio de Cardiología, Buenos Aires, Argentina.

Background: There are well-recognized relationships between thyroid hormones, heart and peripheral vascular system. Thyroid hormones have relevant actions on the heart and circulation, generate multiple effects including hemodynamic changes and exert mediated effects on cardiac cells through gene expression.

Clinical Case: We present a 64-year-old woman with diagnosis of dilated cardiomyopathy with reduced ejection fraction, in whom coronary disease was thought of as the most probable etiology by clinical antecedents but in the evolution, other possible etiologies were to appear. Read More

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January 2020