81,502 results match your criteria Peripheral Vascular Disease


Acute vascular benefits of Finnish sauna bathing in patients with stable coronary artery disease.

Can J Cardiol 2020 Jun 29. Epub 2020 Jun 29.

Cardiovascular prevention and rehabilitation centre, Montreal Heart Institute, Montréal, Canada; Department of pharmacology and physiology, Faculty of medicine, Université de Montréal, Montréal, Canada; Research centre, Montreal Heart Institute, Montréal, Canada. Electronic address:

Background: Finnish sauna bathing habits are associated with a decreased risk of cardiovascular mortality. The physiological adaptations mediating this association remain to be fully elucidated. This study tested the hypothesis that Finnish sauna bathing acutely improves peripheral flow-mediated dilation (FMD) in middle-aged and older adults with stable coronary artery disease (CAD). Read More

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http://dx.doi.org/10.1016/j.cjca.2020.06.017DOI Listing

Dynamic Protein Palmitoylation Cycling: A New Pathway Impacting Peripheral Arterial Disease?

Circ Res 2020 Jul 2;127(2):266-268. Epub 2020 Jul 2.

From the Department of Pharmacology (N.E.B., W.C.S.), Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1161/CIRCRESAHA.120.317113DOI Listing

Temporal dispersion in demyelination of POEMS syndrome and Castleman disease.

Clin Neurophysiol Pract 2020 31;5:112-117. Epub 2020 May 31.

Department of Neurology, Kuala Lumpur Hospital, Jalan Pahang, 50586, Wilayah Persekutuan, Kuala Lumpur, Malaysia.

Objective: We detailed the electrophysiological patterns of peripheral nerve temporal dispersion across spectrum of POEMS syndrome and Castleman disease (CD).

Methods: Compound muscle action potentials (CMAP) duration of 3 patients with POEMS syndrome and 2 with hyaline vascular type CD without clonal plasma cell dyscrasia were retrospectively analysed.

Results: Median and ulnar nerves distal CMAP duration were prolonged in all patients irrespective of plasma cell dyscrasia or M protein. Read More

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http://dx.doi.org/10.1016/j.cnp.2020.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322354PMC

Isolated pulmonary vasculitis associated with nilotinib use: A case report.

Leuk Res Rep 2020 18;14:100214. Epub 2020 Jun 18.

Division of Rheumatology, University of California, Los Angeles, David Geffen School of Medicine, California, USA.

An association between tyrosine-kinase inhibitor therapy for chronic myeloid leukemia and vascular adverse events including peripheral arterial disease, coronary artery disease, and pulmonary hypertension has been described. We present a patient who developed isolated pulmonary artery vasculitis resulting in left pulmonary artery stenosis, in addition to left coronary artery stenosis while on nilotinib. While monitoring for cardiovascular events is important, clinicians should also recognize possible drug-induced vasculitis during chronic nilotinib therapy. Read More

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http://dx.doi.org/10.1016/j.lrr.2020.100214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322170PMC

Emerging Role of Large-bore Percutaneous Axillary Vascular Access: A Step-by-step Guide.

Interv Cardiol 2020 Apr 15;15:e07. Epub 2020 Jun 15.

Division of Cardiology, Department of Medicine, University of Washington Heart Institute Seattle, WA, US.

Advances in transcatheter structural heart interventions and temporary mechanical circulatory support have led to increased demand for alternative sites for large-bore vascular access. Percutaneous axillary artery access is an appealing alternative to femoral access in patients with peripheral arterial disease, obesity or for prolonged haemodynamic support where patient mobilisation may be valuable. In particular, axillary access for mechanical circulatory support allows for increased mobility while using the device, facilitating physical therapy and reducing morbidity associated with prolonged bed rest. Read More

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http://dx.doi.org/10.15420/icr.2019.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312195PMC

Incidence and risk factors associated with postoperative delirium following primary elective total hip arthroplasty: a retrospective nationwide inpatient sample database study.

BMC Psychiatry 2020 Jul 1;20(1):343. Epub 2020 Jul 1.

Department of Orthopaedic Surgery, Division of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 1838 Guangzhou Avenue, Guangzhou, 510515, Guangdong, China.

Background: Postoperative delirium is a common complication following major surgeries, leading to a variety of adverse effects. However, there is a paucity of literatures studying the incidence and risk factors associated with delirium after primary elective total hip arthroplasty (THA) using a large-scale national database.

Methods: A retrospective database analysis was performed based on Nationwide Inpatient Sample (NIS) from 2009 to 2014. Read More

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http://dx.doi.org/10.1186/s12888-020-02742-6DOI Listing

Predictive value of ankle-brachial index for long-term events of ischemic stroke in hemodialysis patients.

Vascular 2020 Jul 1:1708538120925954. Epub 2020 Jul 1.

Department of Nephrology, Tainan Sin-Lau Hospital, Tainan, Taiwan.

Objectives: The ankle-brachial index is a noninvasive modality to evaluate atherosclerosis and is a predictive role for future cardiovascular events and mortality. However, few studies have evaluated its relation to long-term future ischemic stroke in hemodialysis patients. Therefore, we examined the relationship between ankle-brachial index and ischemic stroke events among hemodialysis patients in a seven-year follow-up. Read More

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http://dx.doi.org/10.1177/1708538120925954DOI Listing

COVID-19 as a Vascular Disease: Lesson Learned from Imaging and Blood Biomarkers.

Authors:
Paolo Zamboni

Diagnostics (Basel) 2020 Jun 29;10(7). Epub 2020 Jun 29.

Department of Surgery, Vascular Disease Centre University Hospital of Ferrara, 44124 Cona (Fe), Italy.

COVID-19, a disease initially thought to be prominently an interstitial pneumonia with varying degrees of severity, can be considered a vascular disease with regards to serious complications and causes of mortality. Quite recently, blood clots have emerged as the common factor unifying many of the symptoms initially attributed without an explanation to COVID-19. Cardiovascular biomarkers and particularly, D-dimer and troponin appear to be very powerful prognostic markers, signaling the need for earlier and more aggressive interventions and treatments in order to avoid and/or minimize arterial/venous thromboembolism and myocardial infarct. Read More

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http://dx.doi.org/10.3390/diagnostics10070440DOI Listing

COVID-19 Infection and Neurological Complications: Present Findings and Future Predictions.

Neuroepidemiology 2020 Jul 1:1-6. Epub 2020 Jul 1.

Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari "Aldo Moro"Bari, "Pia Fondazione Cardinale G. Panico", Tricase, Italy.

The present outbreak caused by SARS-CoV-2, an influenza virus with neurotropic potential, presents with neurological manifestations in a large proportion of the affected individuals. Disorders of the central and peripheral nervous system are all present, while stroke, ataxia, seizures, and depressed level of consciousness are more common in severely affected patients. People with these severe complications are most likely elderly with medical comorbidities, especially hypertension and other vascular risk factors. Read More

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http://dx.doi.org/10.1159/000508991DOI Listing

Hyperspectral Imaging Quantification of Mouse Limb Microcirculation Using an Ischemia Reperfusion Model with Phosphodiesterase 5 Inhibitor Preconditioning.

J Laparoendosc Adv Surg Tech A 2020 Jun 29. Epub 2020 Jun 29.

Unistra, Fédération de Médecine Translationnelle, Unité de Recherche 3072, "Mitochondrie, Stress oxydant et Protection Musculaire", Institut de Physiologie, Strasbourg, France.

Peripheral arterial disease has high incidence and complication rates. Vessel recanalization represents the main therapy. However, it induces reperfusion injury. Read More

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http://dx.doi.org/10.1089/lap.2020.0364DOI Listing

Relationship Between Vascular Aging and Left Ventricular Concentric Geometry in Community-Dwelling Elderly: The Northern Shanghai Study.

Clin Interv Aging 2020 4;15:853-863. Epub 2020 Jun 4.

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.

Purpose: There have been few recent studies regarding vascular aging and its relationship with left ventricular (LV) geometry. Moreover, the association of abnormal LV geometry with various kinds of vascular aging has not yet been systematically analyzed. Thus, this study aimed to further elucidate this relationship. Read More

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http://dx.doi.org/10.2147/CIA.S248816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283487PMC

Quantitative analysis of pulmonary vasculature in systemic sclerosis at spirometry-gated chest CT.

Ann Rheum Dis 2020 Jun 30. Epub 2020 Jun 30.

Dept Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Objective: To prospectively investigate whether differences in pulmonary vasculature exist in systemic sclerosis (SSc) and how they are distributed in patients with different pulmonary function.

Methods: Seventy-four patients with SSc undergoing chest CT scan for interstitial lung disease (ILD) screening or follow-up were prospectively enrolled. A thorough clinical, laboratory and functional evaluation was performed the same day. Read More

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http://dx.doi.org/10.1136/annrheumdis-2020-217359DOI Listing

Disparities in Physical Activity Levels in Patients with Peripheral Arterial Disease Across the Atlantic.

Eur J Vasc Endovasc Surg 2020 Jun 27. Epub 2020 Jun 27.

Division of Vascular and Endovascular Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1016/j.ejvs.2020.05.040DOI Listing

Demographic and procedural characteristics in the RECording COurses of vasculaR Diseases (RECCORD) registry - the first 1000 patients.

Vasa 2020 Jul 1:1-7. Epub 2020 Jul 1.

Division of Vascular Medicine, Medical Clinic and Policlinic IV, University Hospital Munich, Munich, Germany.

The RECcording COurses of vasculaR Diseases (RECCORD) registry established by the German Society of Angiology - Society for Vascular Medicine aimed to address the lack in contemporary real-world data regarding current practice of medical and interventional care in vascular patients. We herein report the demographic and procedural characteristics of the first 1000 patients undergoing endovascular revascularization (EVR) for symptomatic peripheral artery disease (PAD). RECCORD is an observational, prospective, multicenter, all-comers registry. Read More

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http://dx.doi.org/10.1024/0301-1526/a000882DOI Listing

Diagnosing Calciphylaxis: A Review With Emphasis on Histopathology.

Am J Dermatopathol 2020 Jul;42(7):471-480

Assistant Professor, Departments of Pathology and Dermatology, University of California, San Francisco, CA.

Calciphylaxis is a cutaneous vasculopathy with high morbidity and mortality characterized by vascular intimal fibrosis, calcification, stenosis, thrombosis, and eventual tissue death due to ischemia. Histopathologic diagnosis is often difficult, frequently necessitating multiple tissues samples due to lack of specific histopathologic features and subtle changes on biopsies of early lesions. In this study, we review the reported clinical and histopathologic features of calciphylaxis, correlating them with relevant imaging, ancillary studies, and pathophysiology. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001526DOI Listing

"Failure-to-Cross" in Patients Undergoing Percutaneous Peripheral Intervention: The Non-Reimbursed Procedure.

Ann Vasc Surg 2020 Jun 27. Epub 2020 Jun 27.

Department of Surgery, Advocate Lutheran General Hospital, Park Ridge, IL. Electronic address:

Background: Percutaneous Peripheral Intervention (PPI) is often the first mode of therapy for patients with symptomatic arterial occlusive disease. Technical success generally remains high although "failure-to-cross" still complicates 5-20% of cases. Extended efforts to cross long, occlusive lesions can utilize significant hospital and practitioner resources. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.06.038DOI Listing

Monitoring the microcirculation in the diagnosis and follow-up of systemic sclerosis patients: focus on pulmonary and peripheral vascular manifestations.

Microcirculation 2020 Jun 30. Epub 2020 Jun 30.

Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Firenze, Florence, Italy.

Systemic sclerosis (SSc) is a connective tissue disease, characterized by vascular damage and progressive fibrosis, affecting the skin and internal organs. The vascular changes include functional and structural abnormalities in the microcirculation, which play a central role not only in diagnosis, but also in the prognosis and follow-up of systemic sclerosis patients. Nailfold videocapillaroscopy (NVC) is a safe, validated, non-invasive, inexpensive, reliable and reproducible method that allows for the evaluation of structural changes in scleroderma microangiopathy. Read More

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http://dx.doi.org/10.1111/micc.12647DOI Listing

Clinical Utilization Pattern of Multiple Strengths of Glimepiride and Metformin Fixed Dose Combinations in Indian Type 2 Diabetes Patients.

J Assoc Physicians India 2020 Jul;68(7):57-61

Vice President, Scientific Services, USV Private Limited, Mumbai, Maharashtra.

Background: In Indian clinical set-up, modern sulfonylurea, particularly glimepiride is still preferred as an add-on to metformin due to its efficacy, safety and cost effectiveness. In view of this, a case-based questionnaire survey was conducted to analyze the clinical utility of multiple strengths of glimepiride and metformin fixed dose combination in type 2 diabetes mellitus (T2DM).

Methods: The case-based questionnaire survey was conducted with 174 health care professionals across India to assess the use of glimepiride and metformin fixed dose combination according to age, duration of diabetes, body mass index (BMI), diabetes complications, concomitant medications like insulin, and statin. Read More

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Open-label multicenter registry on the outcomes of peripheral arterial disease treated by balloon angioplasty with optical frequency domain imaging in superficial femoral artery and popliteal artery (OCEAN-SFA study).

Cardiovasc Interv Ther 2020 Jun 29. Epub 2020 Jun 29.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Although balloon angioplasty for femoropopliteal artery lesions has been associated with restenosis rates of up to 60% at 12 months, the mechanism of restenosis has not been fully evaluated. The aim of this study was to evaluate the relationship between the vascular features observed on optical frequency domain imaging (OFDI) before and after balloon angioplasty of femoropopliteal artery lesions, and restenosis at 6 months. This study was a prospective multicenter single arm study. Read More

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http://dx.doi.org/10.1007/s12928-020-00679-xDOI Listing

Ankle Disarticulation: An Underutilized Approach to Staged Below Knee Amputation-Case Series and Surgical Technique.

J Foot Ankle Surg 2020 Jul - Aug;59(4):869-872

Professor, Department of Plastic and Reconstructive Surgery, MedStar Georgetown University Hospital, Washington, DC. Electronic address:

The staged approach to below knee amputation has proven to be an effective method of achieving functionality after amputation and reducing risk for postamputation complications. Transtibial or "guillotine" amputations are often used as the first-stage amputation. Disarticulation at the ankle joint is an alternative method that can be used with favorable results and benefits. Read More

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http://dx.doi.org/10.1053/j.jfas.2019.10.009DOI Listing
October 2019

Perioperative cardiovascular complications rate and activity of coagulation and fibrinolysis among patients undergoing vascular surgery for peripheral artery disease and abdominal aortic aneurysm.

Vascular 2020 Jun 29:1708538120937127. Epub 2020 Jun 29.

Department of Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Krakow, Poland.

Objectives: To compare preoperative coagulation and fibrinolysis activity and incidence of perioperative complications between patients undergoing vascular procedures for peripheral artery disease and abdominal aortic aneurysm.

Methods: This is a substudy of a prospective observational cohort study (VISION; NCT00512109) in which we recruited patients aged ≥45 years, undergoing surgery for peripheral artery disease and abdominal aortic aneurysm. Blood samples were obtained 24 h preoperatively to measure platelet count, concentrations of coagulation coagulation (fibrinogen, factor VIII, von Willebrand factor:Ristocetin cofactor, antithrombin III), fibrinolysis (dimer D, plasmin-antiplasmin complexes, tissue plasminogen activator) markers and level of soluble CD40 ligand. Read More

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http://dx.doi.org/10.1177/1708538120937127DOI Listing

Dysregulation of microRNA Modulatory Network in Abdominal Aortic Aneurysm.

J Clin Med 2020 Jun 24;9(6). Epub 2020 Jun 24.

Chair and Department of Biology and Genetics, Medical University of Lublin, 4a Chodźki St., 20-093 Lublin, Poland.

Abdominal artery aneurysm (AAA) refers to abdominal aortic dilatation of 3 cm or greater. AAA is frequently underdiagnosed due to often asymptomatic character of the disease, leading to elevated mortality due to aneurysm rupture. MiRNA constitute a pool of small RNAs controlling gene expression and is involved in many pathologic conditions in human. Read More

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http://dx.doi.org/10.3390/jcm9061974DOI Listing

Overexpression of PD-1 on Peripheral Blood Lymphocytes in Patients with Idiopathic Pulmonary Arterial Hypertension and Its Association with High Viral Loads of Epstein-Barr Virus and Poor Clinical Parameters.

J Clin Med 2020 Jun 24;9(6). Epub 2020 Jun 24.

Department of Cardiac and Vascular Diseases, Faculty of Medicine, Jagiellonian University Medical College, Centre for Rare Cardiovascular Diseases, John Paul II Hospital, 31-202 Krakow, Poland.

Idiopathic pulmonary arterial hypertension (IPAH) is a rare but severe disease with the elevated blood pressure in the pulmonary arteries without a known trigger of vascular remodelling. It leads to the right heart failure with reduced survival. Changes in the immunological landscape of the lungs and the periphery are common in IPAH patients, suggesting an immune system dysfunction. Read More

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http://dx.doi.org/10.3390/jcm9061966DOI Listing

Homocysteine concentration and adenosine A receptor production by peripheral blood mononuclear cells in coronary artery disease patients.

J Cell Mol Med 2020 Jun 29. Epub 2020 Jun 29.

C2VN, INSERM, INRA, Aix Marseille University, Marseille, France.

Hyperhomocysteinemia is associated with coronary artery disease (CAD). The mechanistic aspects of this relationship are unclear. In CAD patients, homocysteine (HCy) concentration correlates with plasma level of adenosine that controls the coronary circulation via the activation of adenosine A receptors (A R). Read More

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http://dx.doi.org/10.1111/jcmm.15527DOI Listing

ARM VEIN VERSUS SMALL SAPHENOUS VEIN FOR LOWER EXTREMITY BYPASS IN THE ABSENCE OF BOTH GREAT SAPHENOUS VEINS.

Ann Vasc Surg 2020 Jun 26. Epub 2020 Jun 26.

Department of Vascular and Endovascular Surgery, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.

Background: Bypass surgery remains the gold standard for long and complex arterial occlusions in the lower limb. Vein is regarded superior to prosthetic conduits in peripheral arterial bypass surgery. However, this option is often limited due to previous bypass, stripping, or poor quality of the ipsilateral and/or contralateral great saphenous vein (GSV). Read More

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http://dx.doi.org/10.1016/j.avsg.2020.06.043DOI Listing

[Therapeutic aspects of the choice of antithrombotic therapy in patients with multifocal lesions of peripheral arteries].

Ter Arkh 2019 Sep 15;91(9):158-164. Epub 2019 Sep 15.

Lomonosov Moscow State University.

The article discusses the features of the development and course of the atherosclerotic process in various vascular basins. Variability of factors such as local hemodynamics, differences in the structure of the arteries can influence the formation of atherosclerotic plaque and the progression of the atherosclerotic process. A better understanding of the nature and causes of these differences can help improve the tactics of treatment and prevention of vascular complications. Read More

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http://dx.doi.org/10.26442/00403660.2019.09.000407DOI Listing
September 2019

[Somatic mutation of the V617F JAK2 gene in patients of the cardiovascular diseases].

Ter Arkh 2019 Jul 15;91(7):25-28. Epub 2019 Jul 15.

The Federal Center of Cardiovascular Surgery of Krasnoyarsk.

The JAK2 V617F somatic mutation is one of the most frequent markers of CHIP (clonal hematopoiesis of indeterminate potential). CHIP is characterized by the presence of a myeloid cells clone in peripheral blood in the absence of the sufficient reasons to diagnose the hematologic disease. The CHIP is proposed as a potential independent risk factor for vascular pathology. Read More

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http://dx.doi.org/10.26442/00403660.2019.07.000245DOI Listing

[Atherosclerosis of peripheral arteries in patients with coronary artery disease and type 2 diabetes mellitus].

Ter Arkh 2019 Oct 15;91(10):54-62. Epub 2019 Oct 15.

South-Ural State Medical University.

Aim: To study the features of atherosclerosis of peripheral arteries in patients with coronary artery disease (CAD) depending on the presence of type 2 diabetes mellitus (T2DM) and to identify factors associated with multifocal atherosclerosis.

Materials And Methods: The study included 140 patients (77 men and 63 women) with CAD (mean age 62.0 (56. Read More

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http://dx.doi.org/10.26442/00403660.2019.10.000106DOI Listing
October 2019

[Peripheral nervous system lesion in systemic vasculitis - issues of diagnosis and treatment].

Ter Arkh 2019 Dec 15;91(12):63-69. Epub 2019 Dec 15.

Clinic of modern rheumatology.

Vasculitis is a clinically diverse group of diseases with histopathological signs of blood vessel inflammation, which contributes to vascular damage and ischemic damage to the affected tissues. Vasculitic neuropathy is a common complication of the primary systemic vasculitides, such as polyartertis nodosa and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, systemic diseases of the connective tissue - systemic lupus erythematosus and Sjogren syndrome, vasculitis associated with infection, most often viral hepatitis C and B and non - systemic vasculitis neuropathy. Vessels of medium and small caliber are involved in the pathological process in these diseases. Read More

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http://dx.doi.org/10.26442/00403660.2019.12.000206DOI Listing
December 2019

The association between sympatho-vagal balance and central blood pressures.

Physiol Int 2020 Apr 23. Epub 2020 Apr 23.

6Department of Biobehavioral Sciences, Teachers College, Columbia University, New York, NY, USA.

Purpose: High central blood pressure is more predictive of cardiovascular disease (CVD) versus high peripheral blood pressure. Measures of central pressures (CPs) include, central systolic blood pressure (CSBP) and central diastolic blood pressure. Measures of central pressures augmentation (CPsA) include augmentation pressure (AP) and the augmentation index @ 75 beats·min-1 (AIx@75). Read More

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http://dx.doi.org/10.1556/2060.2020.00005DOI Listing

[Problems and prospects of cell therapy for critical ischaemia of lower limbs].

Angiol Sosud Khir 2020 ;26(2):23-33

Department of Vascular Pathology and Hybrid Surgery, National Medical Research Centre named after Academician Meshalkin E.N. under the RF Ministry of Public Health, Novosibirsk, Russia.

Background: Cell therapy was proposed as a procedure of indirect revascularization for patients with critical ischaemia of lower extremities for whom endovascular and surgical revascularization is impossible. We present herein a review of the state of the art of studies in the field of cell therapy of this cohort of patients.

Basic Provisions: Cell therapy has proved safe, however, the results of studies of efficacy are relatively ambiguous and unconvincing. Read More

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http://dx.doi.org/10.33529/ANGIO2020220DOI Listing
January 2020

Differential Proteomic Expression of Equine Cardiac and Lamellar Tissue During Insulin-Induced Laminitis.

Front Vet Sci 2020 12;7:308. Epub 2020 Jun 12.

Department of Biochemistry and Molecular Biology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, United States.

Endocrinopathic laminitis is pathologically similar to the multi-organ dysfunction and peripheral neuropathy found in human patients with metabolic syndrome. Similarly, endocrinopathic laminitis has been shown to partially result from vascular dysfunction. However, despite extensive research, the pathogenesis of this disease is not well elucidated and laminitis remains without an effective treatment. Read More

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http://dx.doi.org/10.3389/fvets.2020.00308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303262PMC

Rare and Fascinating Case of ST-Elevation Myocardial Infarction Diagnosis From an Underlying Ventricular Paced Rhythm.

Cureus 2020 May 25;12(5):e8274. Epub 2020 May 25.

Cardiology, University of Illinois College of Medicine at Peoria, Peoria, USA.

This is a case of a patient diagnosed with anterior ST-elevation myocardial infarction (STEMI) with a ventricular paced rhythm after the patient underwent a femoral-femoral bypass surgery for severe peripheral vascular disease. The case highlights the diagnosis of STEMI in the setting of paced rhythm in the appropriate clinical setting. Read More

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http://dx.doi.org/10.7759/cureus.8274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314364PMC

Acute Respiratory Failure Secondary to COVID-19 Viral Pneumonia Managed With Hydroxychloroquine/Azithromycin Treatment.

Cureus 2020 May 25;12(5):e8268. Epub 2020 May 25.

Anesthesiology, State University of New York Downstate Medical Center, Brooklyn, USA.

A 74-year-old male was admitted to the Intensive Care Unit (ICU) at State University of New York (SUNY) Downstate Medical Center following acute respiratory failure secondary to coronavirus disease 2019 (COVID-19) viral pneumonia. The patient had significant comorbidities, including a history of lung and esophageal cancer status-post resection, cerebrovascular accident with neurological deficits, diabetes mellitus, hypertension, and peripheral vascular disease. The patient was in septic shock and respiratory failure on admission requiring intubation and mechanical ventilation. Read More

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http://dx.doi.org/10.7759/cureus.8268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314365PMC

2017 JAPAN Critical Limb Ischemia Database (JCLIMB) Annual Report.

Ann Vasc Dis 2020 Jun;13(2):205-233

Since 2013, the Japanese Society for Vascular Surgery has started the project of nationwide registration and tracking database for patients with critical limb ischemia (CLI) who are treated by vascular surgeons. The purpose of this project is to clarify the current status of the medical practice for the patients with CLI to contribute to the improvement of the quality of medical care. This database, called JAPAN Critical Limb Ischemia Database (JCLIMB), is created on the National Clinical Database (NCD) and collects data of patients' background, therapeutic measures, early results, and long-term prognosis as long as five years after the initial treatment. Read More

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http://dx.doi.org/10.3400/avd.ar.20-00018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315241PMC

Prevalence of device use and transmission based precautions in nineteen large Australian acute care public hospitals: Secondary outcomes from a national healthcare associated infection point prevalence survey.

Infect Dis Health 2020 Jun 25. Epub 2020 Jun 25.

School of Nursing and Midwifery, University of Newcastle, Ourimbah, NSW, Australia. Electronic address:

Background: The use of invasive devices increases the risk of healthcare associated infections (HAI). The recent national HAI point prevalence survey secondary outcomes aimed to estimate the prevalence of patients with an indwelling urinary catheter device and vascular access devices; and also identify prevalence of those managed under transmission based precautions (TBP); and those colonised or infected with a multi drug resistant organism (MDRO).

Methods: A point prevalence study was conducted in large acute care Australian public hospitals. Read More

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http://dx.doi.org/10.1016/j.idh.2020.05.006DOI Listing

Involvement of microcirculation in critical ischemia: how to identify it?

Authors:
Pavel Poredos

Int Angiol 2020 Jun 25. Epub 2020 Jun 25.

Department of Vascular Disease, University Medical Centre Ljubljana, Ljubljana, Slovenia -

Critical limb ischemia represents the most severe pattern of peripheral arterial disease (PAD) associated with the high risk of major amputation, cardiovascular events and death. The diagnosis and management of critical limb ischemia (CLI) is often challenging. Systolic ankle and toe pressure measurements are considered to be the basic techniques for the identification of PAD. Read More

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http://dx.doi.org/10.23736/S0392-9590.20.04428-4DOI Listing

Dual Pathway Inhibition for Vascular Protection in Patients with Atherosclerotic Disease: Rationale and Review of the Evidence.

Thromb Haemost 2020 Jun 28. Epub 2020 Jun 28.

Research and Development Pharmaceuticals, Bayer AG, Wuppertal, Germany.

Despite advances in secondary prevention strategies in patients with cardiovascular disease, the residual risk of recurrent atherothrombotic events remains high. Dual-antiplatelet therapy is the standard of care for secondary prevention in patients with acute coronary syndrome (ACS), whereas single antiplatelet therapy, generally with aspirin, is the standard of care for secondary prevention in stable patients with coronary artery disease (CAD), peripheral artery disease (PAD), or cerebrovascular disease. However, atherosclerotic plaque disruption not only triggers platelet activation but also results in thrombin generation because of tissue factor exposure. Read More

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http://dx.doi.org/10.1055/s-0040-1713376DOI Listing

Upregulation of long non-coding RNA MEG3 in type 2 diabetes mellitus complicated with vascular disease: a case-control study.

Mol Cell Biochem 2020 Jun 27. Epub 2020 Jun 27.

Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College, Wenchang West Road 22, Wuhu, 241002, Anhui, China.

Previous studies have indicated that long non-coding RNAs (lncRNAs) were closely related to diabetes. In this study, we aimed to explore the possible role and mechanism of lncRNA MEG3 in the occurrence and development of type 2 diabetes mellitus (T2DM) and its vascular complications. A case-control study involving 115 subjects was conducted, including 53 T2DM patients (37 patients with vascular complication and 16 patients without vascular complications) and 62 healthy subjects. Read More

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http://dx.doi.org/10.1007/s11010-020-03810-xDOI Listing

Axillary access TAVR: Entrapment of a transcatheter aortic valve in the innominate artery with aortic dissection.

Cardiovasc Revasc Med 2020 Jun 18. Epub 2020 Jun 18.

Department of Advanced Cardiopulmonary Therapies and Transplantation, McGovern Medical School, University of Texas Health Science Center-Houston and Memorial Hermann Hospital-Texas Medical Center, 6400 Fannin, Suite 2350, Houston, TX 77030, United States of America. Electronic address:

Non-femoral transcatheter aortic valve replacement (TAVR) is indicated when peripheral vascular disease is diagnosed. We describe the "double-stick" technique via the axillary artery. During the procedure, the pigtail coiled around the TAVR system. Read More

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http://dx.doi.org/10.1016/j.carrev.2020.06.020DOI Listing

Decrease of peripheral resistance after intraoperative administration of iloprost in patients with and without type 2 diabetes mellitus and with peripheral arterial occlusive disease.

Diab Vasc Dis Res 2020 May-Jun;17(5):1479164120930589

Department of Surgery, Vascular and Endovascular Surgery, Wilhelminenspital, Vienna, Austria.

Background: In many cases, Ilomedin infusions are applied as part of a perioperative measure in patients with peripheral arterial occlusive disease because it makes a relevant vasodilatatory effect in patients with type 2 diabetes mellitus and with/without peripheral neuropathy.

Aims: A prospective case-control study was performed to investigate the effect of prostanoids on peripheral resistance in patients with type 2 diabetes mellitus and patients without type 2 diabetes mellitus, as well as the role of peripheral neuropathy in patients undergoing arterial reconstruction.

Methods: Sixty patients undergoing arterial reconstruction were enrolled. Read More

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http://dx.doi.org/10.1177/1479164120930589DOI Listing

A pilot study of next generation sequencing-liquid biopsy on cell-free DNA as a novel non-invasive diagnostic tool for Klippel-Trenaunay syndrome.

Vascular 2020 Jun 26:1708538120936421. Epub 2020 Jun 26.

Candiolo Cancer Institute FPO-IRCCS, Candiolo, Italy.

Objectives: Somatic mosaicism of gene is currently recognized as the molecular driver of Klippel-Trenaunay syndrome. However, given the limitation of the current technologies, somatic mutations are detected only in a limited proportion of Klippel-Trenaunay syndrome cases and tissue biopsy remains an invasive high risky, sometimes life-threatening, diagnostic procedure. Next generation sequencing liquid biopsy using cell-free DNA has emerged as an innovative non-invasive approach for early detection and monitoring of cancer. Read More

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http://dx.doi.org/10.1177/1708538120936421DOI Listing

A prospective community engagement initiative to improve clinical research participation in patients with peripheral artery disease.

SAGE Open Med 2020 13;8:2050312120930915. Epub 2020 Jun 13.

Heart and Vascular Institute, College of Medicine, Penn State University, Hershey, PA, USA.

Objective: Patients diagnosed with peripheral artery disease are difficult to recruit into clinical trials. However, there is currently no high-quality, patient-centered information explaining why peripheral artery disease patients choose to participate or not participate in clinical research studies.

Methods: The current study was a prospective community engagement initiative that specifically asked patients with and without peripheral artery disease: (1) what motivates them to participate in clinical research studies, (2) their willingness to participate in different research procedures, (3) the barriers to participation, (4) preferences about study design, and (5) demographic and disease-related factors influencing participation. Read More

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http://dx.doi.org/10.1177/2050312120930915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294489PMC

Diagnosis of Diabetes Mellitus in Older Adults.

Authors:
S Sethu K Reddy

Clin Geriatr Med 2020 Aug 18;36(3):379-384. Epub 2020 Apr 18.

CMED 2419, Central Michigan University, Mt. Pleasant, MI 48859, USA. Electronic address:

In the United States, 4 out of 10 adults with diabetes are ≥65 years of age. The older adult with diabetes is very likely to be asymptomatic and also at higher risk of vascular disease. New concerns include new diagnosis of diabetes for older adults admitted to hospital and older adults in long-term care facilities. Read More

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http://dx.doi.org/10.1016/j.cger.2020.04.011DOI Listing

Extensive serum biomarker analysis before and after treatment in healing of diabetic foot ulcers using a cytokine antibody array.

Cytokine 2020 Jun 22;133:155173. Epub 2020 Jun 22.

Department of Peripheral Vascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, China.

Diabetic foot ulcers (DFU) remain a serious public health problem. However, the current evaluation and confirmation of the efficacy of DFU is unclear. The present study aimed to measure the alterations of circulating proteins in patients after DFU healing for the exploration of the prognostic biomarkers. Read More

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http://dx.doi.org/10.1016/j.cyto.2020.155173DOI Listing

A National Canadian Survey of Antithrombotic Therapy Following Urgent and Emergent Limb Revascularization.

Can J Cardiol 2020 Jun 22. Epub 2020 Jun 22.

Population Health Research Institute, 20 Copeland Ave, Hamilton, Ontario, Canada; Department of Medicine, 1280 Main St W, McMaster University, Hamilton, Ontario, Canada.

Patients with peripheral artery disease undergoing urgent or emergent lower extremity revascularization have the highest risk of major adverse cardiac (MACE) and limb (MALE) events. While available evidence suggests that antithrombotic therapy reduces this risk, optimal antithrombotic therapy is unclear. We aim to describe current practice patterns for use of antithrombotic therapies after urgent/emergent peripheral artery revascularization. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.06.008DOI Listing

Single stick access using a VA-ECMO arterial return cannula for coronary intervention in cardiogenic shock.

Catheter Cardiovasc Interv 2020 Jun 25. Epub 2020 Jun 25.

The CardioVascular Center, Tufts Medical Center, Boston, Massachusetts, USA.

Use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is growing exponentially for cardiogenic shock and cardiac arrest, and many of these patients require percutaneous coronary intervention (PCI). In some cases, radial arterial access may not feasible among patients with peripheral vascular disease or if larger diameter guide catheters are required. Further, VA-ECMO is commonly used in combination with an intra-aortic balloon pump or Impella, thereby limiting vascular access options and increasing the risk of vascular complications including bleeding and limb ischemia. Read More

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http://dx.doi.org/10.1002/ccd.29073DOI Listing

Three-Year Sustained Clinical Efficacy of Drug-Coated Balloon Angioplasty in a Real-World Femoropopliteal Cohort.

J Endovasc Ther 2020 Jun 25:1526602820931477. Epub 2020 Jun 25.

Universitäts-Herzzentrum Freiburg-Bad Krozingen, Bad Krozingen, Germany.

To report the 36-month outcomes from the prospective, multicenter, single-arm IN.PACT Global Study ( identifier NCT01609296) evaluating the performance of the IN.PACT Admiral drug-coated balloon (DCB) in real-world patients with femoropopliteal occlusive disease. Read More

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http://dx.doi.org/10.1177/1526602820931477DOI Listing

Increased Serum Klotho With Age-Related Aortic Stiffness and Peripheral Vascular Resistance in Young and Middle-Aged Swine.

Front Physiol 2020 9;11:591. Epub 2020 Jun 9.

California Medical Innovations Institute, San Diego, CA, United States.

The anti-aging function of Klotho gene has been implicated in age-related diseases. The physiological importance of Klotho in the progression of arterial stiffness with aging, however, remains unclear. The goal of this study is to determine the correlation of circulating Klotho with early age-related aortic stiffening and peripheral hemodynamics. Read More

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http://dx.doi.org/10.3389/fphys.2020.00591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297143PMC

Evaluation of Peripheral Perfusion in the Presence of Plantar Heel Ulcerations Status After Transmetatarsal Amputation With Achilles Tendon Lengthening.

J Foot Ankle Surg 2020 Jun 21. Epub 2020 Jun 21.

Attending Physician, Department of Plastic Surgery, MedStar Georgetown University Hospital, Washington DC.

The objective of this study is to evaluate peripheral perfusion in patients who developed plantar heel ulcerations status after transmetatarsal amputation and Achilles tendon lengthening. Peripheral perfusion was assessed via contrast angiography of the 3 crural vessels (anterior tibial, posterior tibial, and peroneal arteries), as well as intact heel blush and plantar arch. The secondary objective is to correlate the arterial flow to time to develop heel ulceration and incidence of minor and major lower-extremity amputation. Read More

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http://dx.doi.org/10.1053/j.jfas.2019.11.002DOI Listing