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    Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease.
    PLoS One 2017 24;12(5):e0178353. Epub 2017 May 24.
    Department of Biomedical Engineering, University of Southern California, Los Angeles, California, United States of America.
    Painful vaso-occlusive crisis (VOC), a complication of sickle cell disease (SCD), occurs when sickled red blood cells obstruct flow in the microvasculature. We postulated that exaggerated sympathetically mediated vasoconstriction, endothelial dysfunction and the synergistic interaction between these two factors act together to reduce microvascular flow, promoting regional vaso-occlusions, setting the stage for VOC. We previously found that SCD subjects had stronger vasoconstriction response to pulses of heat-induced pain compared to controls but the relative degrees to which autonomic dysregulation, peripheral vascular dysfunction and their interaction are present in SCD remain unknown. Read More

    Hemoglobin Glycation Index Is Associated with Cardiovascular Diseases in People with Impaired Glucose Metabolism.
    J Clin Endocrinol Metab 2017 May 23. Epub 2017 May 23.
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
    Context: There is a substantial interindividual variation in the association between glycated hemoglobin (HbA1c) and plasma glucose concentrations. Its impact on cardiovascular disease (CVD) has not been comprehensively evaluated.

    Objective: We examined associations between interindividual variations in HbA1c, which was estimated as the hemoglobin glycation index (HGI), and CVD. Read More

    Hypertension and Cardiac Arrhythmias: Executive Summary of a Consensus Document from the European Heart Rhythm Association (EHRA) and ESC Council on Hypertension, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS) and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE).
    Eur Heart J Cardiovasc Pharmacother 2017 May 25. Epub 2017 May 25.
    Institute of Cardiovascular Science, University College London, UK University College London, UK.
    Hypertension (HTN) is a common cardiovascular risk factor leading to heart failure (HF), coronary artery disease (CAD), stroke, peripheral artery disease and chronic renal failure. Hypertensive heart disease can manifest as many types of cardiac arrhythmias, most commonly being atrial fibrillation (AF). Both supraventricular and ventricular arrhythmias may occur in HTN patients, especially in those with left ventricular hypertrophy (LVH), CAD or HF. Read More

    Improved Adherence to a Stepped-care Model Reduces Costs of Intermittent Claudication Treatment in The Netherlands.
    Eur J Vasc Endovasc Surg 2017 May 20. Epub 2017 May 20.
    Department of Vascular Surgery, Catharina Hospital, Eindhoven, The Netherlands; Department of Epidemiology, CAPHRI School for Public Health and Primary Care, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. Electronic address:
    Objective/background: A previous budget impact analysis regarding a supervised exercise therapy (SET) first treatment strategy (stepped care model [SCM]) for Dutch patients with intermittent claudication (IC) showed a low referral rate in 2009, despite solid evidence of the effectiveness of SET programs. Recently, several campaigns have stimulated stakeholders in the field to adopt a SET first strategy in patients with IC. The aim of the present study was to reassess SCM adherence after a 2 year period. Read More

    Longevity Klotho gene polymorphism and the risk of dementia in older men.
    Maturitas 2017 Jul 8;101:1-5. Epub 2017 Apr 8.
    WA Centre for Health & Ageing of Centre for Medical Research, Harry Perkins Institute of Medical Research, Perth, Australia; School of Medicine and Pharmacology, University of Western Australia, Perth, Australia; Department of Geriatric Medicine, Royal Perth Hospital, Perth, Australia.
    Introduction: Klotho variants (KL-VS) have been associated with increased longevity and better cognitive function. It is unclear whether they modulate dementia risk.

    Methods: We recruited 527 men aged 71-87 years who were free of cognitive impairment. Read More

    Association between advanced glycation end-products and functional performance in Alzheimer's disease and mixed dementia.
    Int Psychogeriatr 2017 May 25:1-10. Epub 2017 May 25.
    Research Group Healthy Ageing,Allied Healthcare and Nursing,Hanze University of Applied Sciences,Groningen,the Netherlands.
    Background: People with Alzheimer's disease (AD) experience, in addition to the progressive loss of cognitive functions, a decline in functional performance such as mobility impairment and disability in activities of daily living (ADL). Functional decline in dementia is mainly linked to the progressive brain pathology. Peripheral biomechanical changes by advanced glycation end-products (AGEs) have been suggested but have yet to be thoroughly studied. Read More

    Acute effects of cinacalcet on arterial stiffness and ventricular function in hemodialysis patients: A randomized double-blinded crossover study.
    Medicine (Baltimore) 2017 May;96(21):e6912
    aCHU de Québec Research Center, L'Hôtel-Dieu de Québec Hospital bDepartment of Medicine, Faculty of Medicine, Université Laval, Québec, QC, Canada.
    Background: Serum calcium concentration (Ca) plays an essential role in a vascular muscle tone and myocardial contractility. Previously, we showed that acutely lowering Ca by hemodialysis reduced arterial stiffness. Cinacalcet is a calcimimetic that lowers Ca and parathyroid hormone (PTH). Read More

    Surrogate and clinical endpoints for studies in peripheral artery occlusive disease: Are statistics the brakes?
    Pol Przegl Chir 2017 Apr;89(2):39-48
    Klinikum Magdeburg, Magdeburg, Germany.
    Background: The aim of this review is to present the available clinical and surrogate endpoints that may be used in future studies performed in patients with peripheral artery occlusive disease (PAOD). Importantly, we describe statistical limitations of the most commonly used endpoints and offer some guidance with respect to study design for a given sample size. The proposed endpoints may be used in studies using surgical or interventional revascularization and/or drug treatments. Read More

    Feasibility and Tolerability of Daily Pulse Consumption in Individuals with Peripheral Artery Disease.
    Can J Diet Pract Res 2017 05 24:1-5. Epub 2017 May 24.
    a Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Albrechtsen Research Centre, Winnipeg, MB.
    The present study investigated the feasibility, tolerability, and adherence of daily consumption of whole pulses (dried beans, peas, lentils, chickpeas) by individuals with peripheral artery disease participating in an 8-week study. Study questionnaires and semi-structured interviews for 26 participants were used to determine prestudy pulse consumption and participants' experiences with respect to adherence, positive and negative effects, bowel routine, satiety, and enjoyment of the foods. Although the majority of participants rarely consumed pulses prior to the study, there was a high rate of adherence to daily consumption of the study foods for 8 weeks despite comments regarding study fatigue during the latter part of the study. Read More

    Advances in Clinical Cardiology 2016: A Summary of the Key Clinical Trials.
    Adv Ther 2017 May 23. Epub 2017 May 23.
    Craigavon Cardiac Centre, Southern Trust, Craigavon, Northern Ireland, UK.
    Introduction: The findings of many new cardiology clinical trials over the last year have been published or presented at major international meetings. This paper aims to describe and place in context a summary of the key clinical trials in cardiology presented between January and December 2016.

    Methods: The authors reviewed clinical trials presented at major cardiology conferences during 2016 including the American College of Cardiology (ACC), European Association for Percutaneous Cardiovascular Interventions (EuroPCR), European Society of Cardiology (ESC), European Association for the Study of Diabetes (EASD), Transcatheter Cardiovascular Therapeutics (TCT), and the American Heart Association (AHA). Read More

    Association Between Inflammatory Skin Disease and Cardiovascular and Cerebrovascular Co-Morbidities in US Adults: Analysis of Nationwide Inpatient Sample Data.
    Am J Clin Dermatol 2017 May 22. Epub 2017 May 22.
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Suite 1600, 676 N. St. Clair St., Chicago, IL, 60611, USA.
    Background: Psoriasis, atopic dermatitis or eczema (AD-E), pemphigus, bullous pemphigoid (BP), and hidradenitis are chronic inflammatory skin disorders associated with systemic immune activation, considerable symptom burden, stigma, functional disturbances, and mental health symptoms. All of these might increase cardiovascular risk.

    Objective: The objective of this study was to determine whether these inflammatory skin diseases are associated with increased cardiovascular/cerebrovascular risk and/or disease. Read More

    New technologies in vascular surgery: San Donato's experience in the last decades.
    Eur Heart J Suppl 2016 Apr 29;18(Suppl E):E37-E41. Epub 2016 Apr 29.
    Operative Unit of Vascular Surgery I, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
    The Department of Vascular Surgery I at IRCCS Policlinico San Donato has been part of the Cardiovascular Center "Edmondo Malan" since the end of the 1980s. Surgical activity of the Department has always been designed to prevent and treat vascular diseases such as aneurysms of the thoracic and abdominal aorta and peripheral vessels, carotid artery stenosis, peripheral arterial disease, and chronic venous insufficiency. Excellent results have been achieved with the endovascular treatment of both symptomatic and asymptomatic carotid artery stenosis also by using innovative devices. Read More

    Risk Factors for 30-Day Mortality in Patients with Methicillin-Resistant Staphylococcus aureus Bloodstream Infections.
    Int J Infect Dis 2017 May 19. Epub 2017 May 19.
    Henry Ford Health System, Detroit, Michigan, USA; Wayne State University School of Medicine, Detroit, Michigan, USA.
    Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) blood stream infections (BSI) are a major health care problem accounting for a large percentage of nosocomial infections. The aim of this study was to identify risk factors associated with 30-day mortality in patients with MRSA BSI.

    Methods: This was a retrospective study performed in Southeast Michigan. Read More

    Medical management of claudication.
    J Vasc Surg 2017 May 19. Epub 2017 May 19.
    Johns Hopkins Center for Vascular Medicine, Johns Hopkins University School of Medicine, Baltimore, Md. Electronic address:
    Peripheral artery disease (PAD) is common and associated with significant morbidity and mortality. Optimal medical management of PAD is required for each patient, irrespective of the decision regarding lower extremity revascularization. The goals include reducing cardiovascular morbidity and mortality and improving quality of life. Read More

    Neutrophil-Lymphocyte Ratio in Different Stages of Breast Cancer.
    Acta Med Iran 2017 Apr;55(4):228-232
    Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Research, Kaviani Breast Diseases Institute, Tehran, Iran.
    Despite many advances in the treatment of breast cancer, it is still the second most common cause of death in women in the United States. It has been shown that inflammation plays a major role in the treatment of these cancers and inflammatory factors enhance tumor growth, invasion, metastasis, and vascularization. In this study, we would like to analyze peripheral blood neutrophil-lymphocyte ratio (NLR) in breast cancer patients and its correlation with disease staging. Read More

    Estimating energy expenditure in vascular surgery patients: Are predictive equations accurate enough?
    Clin Nutr ESPEN 2016 Dec 6;16:16-23. Epub 2016 Oct 6.
    Nutrition and Dietetics, Faculty of Medicine, Nursing and Health Sciences, School of Health Sciences, Flinders University, GPO Box 2100, Adelaide, 5001, South Australia, Australia. Electronic address:
    Background & Aims: Malnutrition is prevalent in vascular surgical patients who commonly seek tertiary care at advanced stages of disease. Adjunct nutrition support is therefore pertinent to optimise patient outcomes. To negate consequences related to excessive or suboptimal dietary energy intake, it is essential to accurately determine energy expenditure and subsequent requirements. Read More

    Cardiovascular toxic effects of targeted cancer therapy.
    Jpn J Clin Oncol 2017 May 20:1-7. Epub 2017 May 20.
    Department of Medical Oncology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
    Over the past decade, there has been a major shift in chemotherapy from non-specific cytotoxic drugs to molecular targeted drug therapies. As more molecular targeted therapies are developed, new types of cardiovascular toxicities induced by targeted therapies are a growing problem. Cardiotoxicity induced by the human epidermal growth factor receptor-2 inhibitor trastuzumab manifests as decreased left ventricular ejection fraction. Read More

    Drug-Coated Balloons for long lesions in peripheral arterial disease.
    J Cardiovasc Surg (Torino) 2017 May 22. Epub 2017 May 22.
    Center for Interventional Vascular Therapy, Division of Cardiology, Department of Medicine, Columbia University Medical Center/NY Presbyterian Hospital, New York, NY, USA -
    In the current era, endovascular treatment of long femoropopliteal lesions (>15 cm) is becoming more feasible and favorable, with patency rates that rival surgical outcomes. Drug-coated balloons offer promising results at least to one year follow up although randomized, controlled trials to evaluate its efficacy compared to other treatment modalities (surgical and endovascular alike) is lacking at this time. Read More

    Quality of life in patients with intermittent claudication.
    Gefasschirurgie 2017 18;22(3):159-164. Epub 2017 Apr 18.
    Academic Vascular Surgical Unit, Hull Royal Infirmary, Anlaby Road, HU3 2JZ Hull, UK.
    Background: Intermittent claudication (IC) is a common condition that causes pain in the lower limbs when walking and has been shown to severely impact the quality of life (QoL) of patients. The QoL is therefore often regarded as an important measure in clinical trials investigating intermittent claudication. To date, no consensus exits on the type of life questionnaire to be used. Read More

    Role of Nonneuronal TRPV4 Signaling in Inflammatory Processes.
    Adv Pharmacol 2017 24;79:117-139. Epub 2017 Apr 24.
    Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia. Electronic address:
    Transient receptor potential (TRP) ion channels are important signaling components in nociceptive and inflammatory pathways. This is attributed to their ability to function as polymodal sensors of environmental stimuli (chemical and mechanical) and as effector molecules in receptor signaling pathways. TRP vanilloid 4 (TRPV4) is a nonselective cation channel that is activated by multiple endogenous stimuli including shear stress, membrane stretch, and arachidonic acid metabolites. Read More

    Outcomes of open and endovascular lower extremity revascularization in active smokers with advanced peripheral arterial disease.
    J Vasc Surg 2017 Jun;65(6):1680-1689
    Division of Vascular and Endovascular Surgery, Department of Surgery, University of California, Irvine Medical Center, Orange, Calif. Electronic address:
    Objective: Concern over perioperative and long-term durability of lower extremity revascularizations among active smokers is a frequent deterrent for vascular surgeons to perform elective lower extremity revascularization. In this study, we examined perioperative outcomes of lower extremity endovascular (LEE) revascularization and open lower extremity bypass (LEB) in active smokers with intermittent claudication (IC) and critical limb ischemia (CLI).

    Methods: Active smokers undergoing LEE or LEB from 2011 to 2014 were identified in the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) targeted vascular data set. Read More

    Comparative analysis of peri-operative complications between a multicenter prospective cervical deformity database and the nationwide inpatient sample database.
    Spine J 2017 May 17. Epub 2017 May 17.
    International Spine Study Group, Littleton, CO.
    Background Context: Complication rates for adult cervical deformity are poorly characterized given the complexity and heterogeneity of cases.

    Purpose: To compare peri-operative complication rates following adult cervical deformity corrective surgery between a prospective multi-center database for cervical deformity patients (PCD) and Nationwide Inpatient Sample (NIS).

    Study Design/setting: Retrospective review of prospective databases. Read More

    Descriptive study of the frequency of medical adhesive-related skin injuries in a vascular clinic.
    J Vasc Nurs 2017 Jun;35(2):86-89
    Division of Vascular and Endovascular Surgery, Department of Surgery, University of Virginia Health System, Charlottesville, Virginia. Electronic address:
    A medical adhesive can be defined as a product used to secure a device (ie, tape, dressing, catheter, electrode, and ostomy pouch) to the skin. Skin injury related to medical adhesive usage occurs across all care settings with medical adhesive-related skin injuries (MARSIs) playing a significant role with patient safety. The purpose of this descriptive prospective study was to assess all adult patients with wounds seen in the vascular clinic for MARSI by the CWOCN NP over a 3-month time period. Read More

    The patient's experience of amputation due to peripheral arterial disease.
    J Vasc Nurs 2017 Jun;35(2):57-63
    Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden; Wound Centre, Södersjukhuset AB, Stockholm, Sweden.
    It is not uncommon that patients with peripheral arterial disease (PAD) need to undergo a lower limb amputation, with or without previous revascularization attempts. Despite that, the patient's experience of the amputation has been scarcely studied. The aim of this qualitative study was to describe the patient's experience of amputation due to PAD. Read More

    Patient outcomes following lower leg major amputations for peripheral arterial disease: A series review.
    J Vasc Nurs 2017 Jun;35(2):49-56
    Sydney Local Health District, New South Wales, Australia.
    Introduction: Despite improvements in revascularization, major amputation remains a significant part of the case-mix in vascular surgical units. These patients tend to be elderly with complex pathology, resulting in poor outcomes and longer lengths of stay (LOS).

    Aim: This series review provides a description of the patient complexities and outcomes in an Australian cohort undergoing major lower limb amputation for peripheral arterial disease. Read More

    Review of Article: Leeper, N.J., Myers, J., Zhou, M., Nead, K.T., Syed, A., Kojima, Y. … Cooke, J.P. (2013). Exercise capacity is the strongest predictor of mortality in patients with peripheral arterial disease. Journal of Vascular Surgery, 57, 728-33.
    J Vasc Nurs 2017 Jun 28;35(2):112-113. Epub 2017 Apr 28.
    PAD PRAIRIE Initiative: Promoting Healthy Aging and Mobility in Rural Minnesota, University of Minnesota, School of Nursing, Minneapolis, Minnesota. Electronic address:

    Bi-dimensional variational mode decomposition of laser speckle contrast imaging data: A clinical approach to critical limb ischemia?
    Comput Biol Med 2017 May 13;86:107-112. Epub 2017 May 13.
    University Hospital, Lab Physiology and Vascular Investigations, 49000 Angers, France.
    The number of patients suffering from peripheral arterial occlusive disease (PAOD) is growing worldwide. PAOD corresponds to an impairment of perfusion in the distal portion of some arteries that can generate critical limb ischemia. For some patients, the pathology leads to the necessity of amputation. Read More

    Acute impact of drinking coffee on the cerebral and systemic vasculature.
    Physiol Rep 2017 May;5(10)
    Department of Biomedical Engineering, Toyo University, Kawagoe, Saitama, Japan
    Previous studies have suggested that the risk of ischemic stroke increases immediately after drinking coffee. Indeed, drinking coffee, that is, caffeine, acutely increases arterial stiffness as well as blood pressure and peripheral vascular resistance. On the other hand, it has been reported that arterial stiffening is associated with elevation in the pulsatility index (PI) of cerebral blood flow (CBF), which increases the risk of brain disease. Read More

    Two-year outcome and risk factors for mortality in patients with coronary artery disease and renal failure: The prospective, observational CAD-REF Registry.
    Int J Cardiol 2017 May 7. Epub 2017 May 7.
    Department of Nephrology, Hypertension, and Rheumatology, University Hospital Muenster, Muenster, Germany. Electronic address:
    Background: Chronic kidney disease (CKD) and coronary artery disease (CAD) are strongly associated. CAD is the most frequent cause of cardiovascular death in patients with CKD.

    Methods: The prospective observational nationwide multicenter Coronary Artery Disease and REnal Failure (CAD-REF) Registry enrolled 3352 patients with angiographically documented CAD classified according to their baseline estimated glomerular filtration rate (eGFR) into 5 groups according to the K/DOQI-guidelines. Read More

    Medium-term effect of sublingual l-glutathione supplementation on flow-mediated dilation in subjects with cardiovascular risk factors.
    Nutrition 2017 Jun 7;38:41-47. Epub 2017 Jan 7.
    CNR Institute of Clinical Physiology, Milan and Pisa, Italy.
    Objective: Supplementation of glutathione (GSH) may be a positive strategy to improve the endogenous antioxidant defense required to counteract many acute and chronic diseases. However, the efficacy of GSH treatment seems to be closely related to type of administration, degree of absorption, and increase of its concentrations. The aim of this study was to test a new sublingual formulation of L-GSH, which enters directly the systemic circulation, to assess its efficacy on circulating biochemical markers of hepatic metabolism, lipid profile, and oxidative stress and on peripheral vascular function compared with placebo in patients with cardiovascular risk factors (CVRF). Read More

    BAlloon versus Stenting in severe Ischaemia of the Leg-3 (BASIL-3): study protocol for a randomised controlled trial.
    Trials 2017 May 19;18(1):224. Epub 2017 May 19.
    Heart of England NHS Foundation Trust, Netherwood House, Solihull Hospital, University Department of Vascular Surgery, Lode Lane, Solihull, B91 2JL, UK.
    Background: Severe limb ischaemia (SLI) is defined as the presence of rest pain and/or tissue loss secondary to lower extremity atherosclerotic peripheral arterial disease. The superficial femoral and popliteal arteries are the most commonly diseased vessels in such patients and are being increasingly treated using endovascular revascularisation techniques. However, it is currently unknown whether drug-eluting stents and drug-coated balloons confer additional clinical benefits over more established techniques using plain balloons and bare metal stents, or whether they represent a cost-effective use of NHS resources. Read More

    Greater Frequency of Fruit and Vegetable Consumption Is Associated With Lower Prevalence of Peripheral Artery Disease.
    Arterioscler Thromb Vasc Biol 2017 Jun 18;37(6):1234-1240. Epub 2017 May 18.
    From the Leon H. Charney Division of Cardiology, Department of Medicine (S.P.H., E.G., J.S.B.), Division of Vascular Surgery, Department of Surgery (C.B.R., M.A.A., J.S.B.), and Division of Biostatistics, Department of Population Health (Y.G., J.F.X.), New York University Langone Medical Center, New York University School of Medicine, NY.
    Objective: Although fruit and vegetable (F&V) consumption is associated with lower risk of coronary heart disease and stroke, its association with peripheral artery disease (PAD) is less certain. We, thus, sought to characterize F&V intake and investigate the association between F&V consumption and presence of PAD in a large community sample.

    Approach And Results: Self-referred participants at >20 000 US sites who completed medical and lifestyle questionnaires were evaluated by screening ankle brachial indices for PAD (ankle brachial index ≤0. Read More

    Statement for Doppler waveforms analysis.
    Vasa 2017 May 19:1-9. Epub 2017 May 19.
    9 Médecine vasculaire, CHU Toulouse, Toulouse, France.
    Peripheral artery disease of the lower limbs (PAD) is a common disease. Evaluation of PAD is primarily based on non-invasive examinations with analysis of the arterial Doppler signal being a key element. However, the description of arterial Doppler waveforms morphologies varies considerably across medical schools and from country to country. Read More

    Geographic variation and risk factors for systemic and limb ischemic events in patients with symptomatic peripheral artery disease: Insights from the REACH Registry.
    Clin Cardiol 2017 May 18. Epub 2017 May 18.
    FACT (French Alliance for Cardiovascular Trials), French Clinical Research Infrastructure Network, University Hospital Departments-FIRE, Hôpital Bichat, Public Assistance Hospitals of Paris, Paris Diderot University, Sorbonne University Paris Cité, and National Institute of Health and Medical Research, U-1148 Paris, France.
    Background: Patients with symptomatic peripheral artery disease (PAD) are at high risk of ischemic events. However, data about predictors of this risk are limited.

    Hypothesis: We analyzed baseline characteristics and 4-year follow-up of patients enrolled in the international REduction of Atherothrombosis for Continued Health (REACH) Registry with symptomatic PAD and no history of stroke/transient ischemic attack to describe annual rates of recurrent ischemic events globally and geographically. Read More

    The Influence of Heating on Toe pressure in Patients with Peripheral Arterial Disease.
    Scand J Surg 2017 May 1:1457496917705994. Epub 2017 May 1.
    1 Department of Vascular Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
    Background And Aim: The toe skin temperature in vascular patients can be low, making reliable toe pressure measurements difficult to obtain. The aim of this study was to evaluate the effect of heating on the toe pressure measurements.

    Materials And Methods: A total of 86 legs were examined. Read More

    [Choosing wisely recommendations in angiology].
    Internist (Berl) 2017 May 17. Epub 2017 May 17.
    Praxisklinik Herz und Gefäße, Akademische Lehrpraxisklinik der TU Dresden, Forststr. 3, 01099, Dresden, Deutschland.
    Background: The Choosing wisely initiative addresses measures of high medical impact which are frequently not appropriately performed according to expert opinion.

    Objective: To increase the quality of indications by providing supportive information on diagnostic and therapeutic measures in the field of angiology.

    Materials And Methods: As part of the Choosing wisely initiative, the German Society of Angiology has constructed five positive recommendations on underused measures and five negative recommendations concerning those possibly overused. Read More

    The use of intraoperative epiaortic ultrasonography in monitoring patients over 75 years old treated with aortic valve replacement.
    Kardiochir Torakochirurgia Pol 2017 Mar 31;14(1):10-15. Epub 2017 Mar 31.
    Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, SMDZ in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, Zabrze, Poland.
    Introduction: Epiaortic ultrasound scanning (EAS) extended the use of ultrasound to the intraoperative diagnosis of aortic pathology. Surgical palpation of the ascending aorta underestimates the presence and severity of atherosclerotic plaques. Epiaortic ultrasound scanning has been used as an adjunct to transesophageal echocardiography (TEE) or as a primary direct diagnostic tool for imaging the ascending aorta as well as the aortic arch, which gained prominence as part of a multipronged intraoperative strategy to reduce atherosclerotic emboli. Read More

    NK1.1(+) cells promote sustained tissue injury and inflammation after trauma with hemorrhagic shock.
    J Leukoc Biol 2017 May 17. Epub 2017 May 17.
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;
    Various cell populations expressing NK1.1 contribute to innate host defense and systemic inflammatory responses, but their role in hemorrhagic shock and trauma remains uncertain. NK1. Read More

    Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease.
    N Engl J Med 2017 05;376(20):1933-1942
    From the Cleveland Clinic Coordinating Center for Clinical Research (C5Research), Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland (A.M.L., V.M., E.M., K.W., D.M., S.E.N.); South Australian Heart and Medical Research Institute, University of Adelaide, Adelaide (S.J.N.), and School of Medical Sciences, University of New South Wales, Sydney (P.J.B.) - both in Australia; Eli Lilly, Indianapolis (J.S.R., G.R., B.V., G.W.); Washington Cardiovascular Associates, Medstar Research Institute, Washington, DC (H.B.B.); Centre for Cardiovascular Science, University of Edinburgh, Edinburgh (K.A.A.F.); Beth Israel Deaconess Medical Center, Boston (C.M.G.); Duke University Medical Center, Durham, NC (C.G.); Université Sorbonne Paris 6, ACTION Study Group, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Institut de Cardiologie, Paris (G.M.); Penn Heart and Vascular Center, Philadelphia (D.R.); Columbia University, New York (A.R.T.), and Saratoga Cardiology Associates, Saratoga Springs (D.K.) - both in New York; St. Michael's Hospital, Toronto (S.G.), Recherche Médicale Saint-Jérôme, Saint-Jérôme, QC (Y.P.), and Centre de Santé et de Services Sociaux du Nord de Lanaudière-Centre Hospitalier Régional de Lanaud, Saint-Charles-Borromée, QC (S.K.) - all in Canada; Instituto Cardiovascular de Buenos Aires, Buenos Aires (D.C.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Heart Institute (InCor)-University of São Paulo Medical School, São Paulo (J.C.N.); Hospital Central Dr. Ignacio Morones Prieto, San Luis Potosi, Mexico (J.L.L.-P.); the First Affiliated Hospital of Harbin Medical University, Harbin, China (W.L.); and South Oklahoma Heart Research, Oklahoma City (N.T.).
    Background: The cholesteryl ester transfer protein inhibitor evacetrapib substantially raises the high-density lipoprotein (HDL) cholesterol level, reduces the low-density lipoprotein (LDL) cholesterol level, and enhances cellular cholesterol efflux capacity. We sought to determine the effect of evacetrapib on major adverse cardiovascular outcomes in patients with high-risk vascular disease.

    Methods: In a multicenter, randomized, double-blind, placebo-controlled phase 3 trial, we enrolled 12,092 patients who had at least one of the following conditions: an acute coronary syndrome within the previous 30 to 365 days, cerebrovascular atherosclerotic disease, peripheral vascular arterial disease, or diabetes mellitus with coronary artery disease. Read More

    Midterm Results of Low-Profile Stents to Treat Atherosclerotic Iliac Artery Disease.
    J Endovasc Ther 2017 Jun;24(3):349-354
    1 Department of Surgery, Vascular and Endovascular Surgery Unit, San Giovanni di Dio Hospital, Florence, Italy.
    Purpose: To evaluate the safety and effectiveness of low-profile 4-F stents for the treatment of atherosclerotic iliac artery lesions.

    Methods: Between January 2009 and December 2015, 63 patients (mean age 69.3 years; 42 men) received low-profile stents (Astron Pulsar or Pulsar-18) at the discretion of the operator to treat iliac artery occlusive disease. Read More

    Managing refractory cryoglobulinemic vasculitis: challenges and solutions.
    J Inflamm Res 2017 8;10:49-54. Epub 2017 May 8.
    Institute of Rheumatology, School of Medicine, University of Belgrade, Belgrade, Serbia.
    Cryoglobulinemia is thought to be a rare condition. It may be an isolated disorder or secondary to a particular disease. According to immunoglobulin composition, cryoglobulinemia is classified into three types. Read More

    The Consequences of Real Life Practice of Early Abdominal Aortic Aneurysm Repair: A Cost-Benefit Analysis.
    Eur J Vasc Endovasc Surg 2017 May 12. Epub 2017 May 12.
    Department of Surgery, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands. Electronic address:
    Background: The reported 54 mm median intervention diameter for endovascular aneurysm repair (EVAR) in the Vascular Quality Initiative and European data from the Pharmaceutical Aneurysm Stabilisation Trial (PHAST) implies that in real life the majority of abdominal aortic aneurysm (AAA) repairs occur at diameters smaller than the consensus intervention threshold of 55 mm. This study explores the potential consequences of this practice.

    Methods: The differences between real life AAA repair and consensus based intervention threshold were explored in reported data from vascular quality initiatives and PHAST. Read More

    Redox regulation of ischemic limb neovascularization - What we have learned from animal studies.
    Redox Biol 2017 May 4;12:1011-1019. Epub 2017 May 4.
    Aston Medical Research Institute, Aston Medical School, UK.
    Mouse hindlimb ischemia has been widely used as a model to study peripheral artery disease. Genetic modulation of the enzymatic source of oxidants or components of the antioxidant system reveal that physiological levels of oxidants are essential to promote the process of arteriogenesis and angiogenesis after femoral artery occlusion, although mice with diabetes or atherosclerosis may have higher deleterious levels of oxidants. Therefore, fine control of oxidants is required to stimulate vascularization in the limb muscle. Read More

    Intravascular Ultrasound Validation of Contemporary Angiographic Scores Evaluating the Severity of Calcification in Peripheral Arteries.
    J Endovasc Ther 2017 May 1:1526602817708796. Epub 2017 May 1.
    9 Lankenau Medical Center, Wynnewood, PA, USA.
    Purpose: To validate 3 angiographic scoring systems for peripheral artery calcification using intravascular ultrasound (IVUS) as the gold standard.

    Methods: The study employed preprocedure angiography and IVUS data from 47 patients (median age 72 years; 34 men) in the 55-patient JetStream G3 Calcium Study ( ClinicalTrials.gov identifier NCT01273623) to validate the 3 angiographic scoring systems [Peripheral Academic Research Consortium (PARC), Peripheral Arterial Calcium Scoring System (PACSS), and the DEFINITIVE Ca(++) trial]. Read More

    Lower extremity computed tomography angiography can help predict technical success of endovascular revascularization in the superficial femoral and popliteal artery.
    J Vasc Surg 2017 May 11. Epub 2017 May 11.
    Division of Vascular Surgery, Stanford University, Stanford, Calif.
    Objective: Preprocedural computed tomography angiography (CTA) assists in evaluating vascular morphology and disease distribution and in treatment planning for patients with lower extremity peripheral artery disease (PAD). The aim of the study was to determine the predictive value of radiographic findings on CTA and technical success of endovascular revascularization of occlusions in the superficial femoral artery-popliteal (SFA-pop) region.

    Methods: Medical records and available imaging studies were reviewed for patients undergoing endovascular intervention for PAD between January 2013 and December 2015 at a single academic institution. Read More

    The BCR/ABL tyrosine kinase inhibitor, nilotinib, stimulates expression of IL-1β in vascular endothelium in association with downregulation of miR-3p.
    Leuk Res 2017 May 5;58:83-90. Epub 2017 May 5.
    Department of Hematology, Fukushima Medical University, Hikarigaoka-1, Fukushima 960-1295, Japan. Electronic address:
    BCR/ABL tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis for in dividuals with chronic myeloid leukemia (CML). However, many patients treated with TKIs suffer from TKI-related complications. In particular, vascular events such as peripheral artery occlusive disease have become aserious clinical problem for patients who receive the TKI, nilotinib. Read More

    Hospitalization for Charcot neuroarthropathy in diabetes: A population study in Italy.
    Diabetes Res Clin Pract 2017 Apr 28;129:25-31. Epub 2017 Apr 28.
    Diabetes Unit and Diabetes Foot Unit, San Jacopo Hospital, USL Centro-Toscana, Pistoia, Italy.
    Aims: To provide data on hospitalization and incidence rates of Charcot neuroarthropathy (CN) and its relation to lower limbs' amputations/revascularizations in population with diabetes of Italy as well as of one of its regions (Tuscany).

    Methods: Hospitalizations with CN diagnosis (codes ICD-9-CM: 7130, 7135, 7138) have been recorded in people with diabetes over years 2003-2013 in Italy and 2008-2015 in Tuscany. Amputations, peripheral vascular disease, revascularizations and infections were likewise evaluated. Read More

    Cross-talk Between Enzymes Matrix-metalloproteinsese 2 and 9 and Regulatory T-cell Immunity in the Global Burden of Atherosclerosis.
    Scand J Immunol 2017 May 13. Epub 2017 May 13.
    Department of Physiology and Immunology, Medical Faculty, University of Rijeka.
    Changes in immune and inflammatory responses may play a crucial role in the development and progression of atherosclerosis, as an autoimmune, chronic and progressive inflammatory disease. Immunological activity and vascular inflammation during atherosclerosis can be modulated by autoimmune responses against self-antigens, according to changeable risk factors (cholesterol, oxidized low-density lipoprotein (ox-LDL) in the vascular wall, fatty acids, etc.) and accompanied by accumulation of leucocytes and proinflammatory cytokines, which stimulate the transcription of matrix-metalloproteinases (MMPs), whose concentration are increased in foam cell rich regions. Read More

    Feasibility and safety of transfemoral sheathless portico aortic valve implantation: Preliminary results in a single center experience.
    Catheter Cardiovasc Interv 2017 May 13. Epub 2017 May 13.
    Heart Valve Clinic, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
    Background: Feasibility of transfemoral (TF) transcathteter aortic valve replacement (TAVR) is limited by the smallest diameter, the calcification and tortuosity of the iliofemoral access vessels. The use of the Portico system without delivery sheath results in significantly lower profile delivery system compared to standard technique. We herein report our single center experience, feasibility and safety of such an approach. Read More

    Perfusion index and left ventricular output correlation in healthy term infants.
    Eur J Pediatr 2017 May 12. Epub 2017 May 12.
    Division of Neonatology, Careggi University Hospital, University of Florence School of Medicine, Largo Brambilla 3, 50141, Florence, Italy.
    Perfusion index (PI) is a non-invasive marker of peripheral perfusion which is detected by an oximeter. We aimed to assess the correlation between PI and left ventricular output (LVO) in healthy term infants at the time of the screening for congenital heart disease (CHD). PI was measured at 48 ± 2 h of life in the infant's right hand (PIrh) and in 1 foot (PIf) contemporary to SpO2 for CHD screening. Read More

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