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Andes Pediatr 2022 Apr;93(2):247-252

Hospital Universitario Central de Asturias, Oviedo, España.

Introduction: Central Giant Cell Granuloma is an infrequent bone lesion located mainly in the maxillary bone. The main treatment is surgery with wide margins, so it sometimes causes great morbidity and esthetic al terations. Denosumab, a RANK-ligand inhibitor monoclonal antibody, has been presented as a valid therapeutic alternative in the treatment of these lesions. Read More

J Oral Pathol Med 2022 Jun 15. Epub 2022 Jun 15.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

Background: Giant cell granuloma of the jaws are benign osteolytic lesions of the jaws. These lesions are genetically characterized by mutually exclusive somatic mutations at TRPV4, KRAS, and FGFR1, and a fourth molecular subgroup which is wild-type for the three mutations. Irrespective of the molecular background, giant cell granulomas show MAPK/ERK activation. Read More

Anticancer Res 2022 Jun;42(6):2945-2952

Institute of Human Genetics, Otto-von-Guericke University, Magdeburg, Germany.

Background/aim: In the autosomal dominant hereditary disease neurofibromatosis type 1 (NF1), lesions of the jaw develop in isolated cases, which are diagnosed as central giant cell granuloma (CGCG). This study aimed to clarify the genetic basis of a bone lesion in a syndromic patient.

Case Report: The NF1 patient had developed a CGCG that recurred after local excision. Read More

Virchows Arch 2022 May 25. Epub 2022 May 25.

Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

Non-ossifying fibroma (NOF) and central giant cell granuloma (CGCG) are both benign tumours of bone with overlapping morphology and similar mutations in the RAS/MAPK pathway. However, NOF is located in the long bones with regression after puberty in contrast to CGCG which is located in the jaw bones and does not regress spontaneously. We hypothesised that endocrine regulation by oestrogen plays a role in the spontaneous regression in NOF. Read More

Ann Pathol 2022 Apr 3;42(3):214-226. Epub 2022 May 3.

Service de pathologie, hôpital Trousseau, CHRU de Tours, Tours, France; Université de Tours, Tours, France.

Giant cell tumors of bone (GCTs) are rare mesenchymal tumors classified as intermediate in the WHO 2020 classification, i.e. neither completely benign nor definitely malignant, due to recurrence (frequent) and pulmonary metastases (rare). Read More

Cytojournal 2022 4;19:11. Epub 2022 Mar 4.

Department of Oncopathology, Malabar Cancer Centre, Moozhikkara, Kannur, Kerala, India.

A few studies are dealing with the role of fine-needle aspiration cytology in diagnosing osteoarticular tuberculosis (TB). The present study was undertaken to study the cytomorphological features of six cases of osteoarticular TB throughout 1 year, diagnosed by fine-needle aspiration cytology. The Papanicolaou, Giemsa, Ziehl-Neelsen, and periodic acid-Schiff stains were used in each case. Read More

Int J Surg Case Rep 2022 May 14;94:107082. Epub 2022 Apr 14.

Department of Pathology and Clinical Laboratory, French Medical Institute for Mothers and Children (FMIC), Kabul, Afghanistan. Electronic address:

Introduction And Importance: Giant cell granulomas (GCG) and ossifying fibroma (OF) of the jaw are benign reactive lesions. GCG characterized by the presence of abundant multinucleated giant cells in a cellular stroma. On the other hand, the characteristic feature of OF is benign connective tissue replaces the normal bone. Read More

Clin Case Rep 2022 Apr 8;10(4):e05709. Epub 2022 Apr 8.

Department of Dermatology Fattouma Bourguiba University Hospital of Monastir Monastir Tunisia.

Annular elastolytic giant cell granuloma (AEGCG) is a benign skin disorder, with, unknown cause. It appears as erythematous papules or annular plaques. Few challenging cases of AEGCG have been reported in the literature. Read More

Cesk Patol 2022 ;58(1):52-56

Penile paraffinoma or sclerosing lipogranuloma is a disease occurring uncommonly in Czechia; a pathologist meets this only rarely. Microscopically, we deal with chronic fibroproductive inflammation localised usually in subcutaneous tissue of the penis. It is caused by previous voluntary injection of liquid paraffin / mineral oil for the purpose of penis circumference augmentation, usually performed by a non-healthcare person or by the patient himself. Read More

Acta Stomatol Croat 2022 Mar;56(1):77-88

Department of Oral and Maxillofacial Medicine and Diagnostic Sciences, Case Western Reserve University, Cleveland, OH.

Objective: Giant cell lesions of the jaws (GCLJ) may rarely occur in the setting of RASopathy syndromes such as Noonan syndrome or neurofibromatosis I. Recently, central giant cell granulomas (CGCG), the most common of the GCLJ, have been recognized as benign neoplasms characterized by Ras/MAPK signaling pathway mutations. This provides a rational basis for understanding GCLJ in RASopathy syndromes as syndromically occurring CGCG. Read More

Bone 2022 06 21;159:116395. Epub 2022 Mar 21.

Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia; Child Health Research Centre, The University of Queensland, Brisbane, QLD, Australia; Department of Endocrinology and Diabetes, Queensland Children's Hospital, Brisbane, QLD, Australia.

Background: Central giant cell granulomas (CGCG) are rare osteolytic, benign but often locally aggressive tumours of bone. Surgical curettage may not be possible in extensive lesions and resection carries high morbidity, especially in growing children, and previous medical therapies have had variable efficacy and high recurrence rates. Interruption of receptor activator of nuclear factor-kappa B ligand (RANKL) signalling holds promise as an effective therapeutic strategy for these tumours. Read More

Orv Hetil 2022 03 13;163(11):446-452. Epub 2022 Mar 13.

2 Semmelweis Egyetem, Fogorvostudományi Kar, Arc-Állcsont-Szájsebészeti és Fogászati Klinika Budapest, Mária u. 52., 1085 Magyarország.

Összefoglaló. A cherubismus ritka, autoszomális dominánsan öröklődő megbetegedés. A fibroossealis elváltozások csoportjába tartozik. Read More

Acta Biomater 2022 04 9;143:310-319. Epub 2022 Mar 9.

Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, 300 Halket St, Pittsburgh, PA 15213, USA; Magee-Womens Research Institute, University of Pittsburgh, 204 Craft Ave, Pittsburgh, PA 15213, USA.

Objective: Urogynecology meshes, typically manufactured from polypropylene, are widely used in the surgical treatment of stress urinary incontinence and pelvic organ prolapse. However, mesh-associated complications such as mesh exposure can develop in women undergoing mesh implantation, for which diabetes is an independent risk factor. We aimed to define the impact of diabetes on the vaginal immune response to mesh by comparing diabetic vs. Read More

J Cutan Pathol 2022 Jul 21;49(7):651-657. Epub 2022 Mar 21.

Department of Dermatology, Showa University School of Medicine, Tokyo, Japan.

We report two cases of eyebrow granulomas in patients who underwent a permanent eye makeup procedure. A rash was observed 16 months after the procedure in Case 1, and 10 years after the procedure in Case 2. Histopathologically, both patients exhibited noncaseating epithelioid cell granulomas. Read More

In Vivo 2022 Mar-Apr;36(2):1021-1029

Department of Orthodontics, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.

Background: Noonan syndrome (NS) is a multigenic disorder with a highly variable phenotype. Cardiac disorders and a predisposition to neoplasm often require early medical attention. Central giant central lesions (CGCLs) of the jaws are part of the phenotype. Read More

Arch Oral Biol 2022 Apr 21;136:105385. Epub 2022 Feb 21.

Department of Medical Pathology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey. Electronic address:

Objective: To examine and compare the immunohistochemical expressions of IL-1β, IL-6, IL-17 and TNF-α in peripheral giant cell granuloma (PGCG) and peripheral ossifying fibroma (POF).

Design: The study included 20 POF and 20 PGCG cases diagnosed at the Pathology Department of Eskişehir Osmangazi University Medical Faculty. Hematoxylin & Eosin-stained slides obtained from each biopsy specimen were re-evaluated, and IL-1β, IL-6, IL-17 and TNF-α antibodies were investigated immunohistochemically. Read More

Acta Derm Venereol 2022 Mar 28;102:adv00684. Epub 2022 Mar 28.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, No.1, Shuaifuyuan, Dongcheng District, Beijing 100730, China.

Elastolytic giant cell granuloma, an idiopathic granulomatous dermatosis, is characterized by annular plaques on sun-exposed areas, and has been termed actinic granuloma or annular elastolytic giant cell granuloma. Many atypical clinical manifestations and lesions involving sun-protected areas have been reported. The aims of this retrospective study of 105 patients were to summarize the clinical and histological features of patients with this condition; to provide evidence for the viewpoint that elastolytic giant cell granuloma is a better term to include all clinical morphological types presenting with elastolysis, elastophagocytosis, and an infiltrate of multinucleated giant cells histologically; and to establish a new clinical classification. Read More

J Inflamm Res 2022 2;15:621-634. Epub 2022 Feb 2.

Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, People's Republic of China.

Purpose: The presence of Langhans giant cell (LGC) is a hallmark of mycobacterium-induced granuloma. The molecular characteristics and functions of LGC remain unclear to date. The study aimed to systematically characterize the molecular characteristics of LGC and reveal the potential functions. Read More

J Indian Soc Periodontol 2022 Jan-Feb;26(1):75-78. Epub 2021 Sep 27.

Department of Pathology, Hamdard Institute of Medical Sciences and Research and Associated HAHC Hospital, Jamia Hamdard, New Delhi, India.

It is often documented that chronic irritation could be an etiology of oral cancer; yet out of negligence little heed is paid to any sort of discomfort until it grows to a sizable mass where it is difficult to go unnoticed. Intraorally, the source of irritation could vary from a jagged tooth edge to a chronic cheek bite. Furthermore, the removable prosthesis and orthodontic appliances can lead to alteration of the oral mucosal tissue. Read More

Ann Diagn Pathol 2022 Jun 2;58:151910. Epub 2022 Feb 2.

Department of Spinal Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, China. Electronic address:

Objective: To explore the pathological features of Brucella spondylitis (BS) under the optical microscope, thus providing pathological references for the diagnosis.

Methods: We retrospectively analyzed 70 BS patients (42 males and 28 females, mean age 52.01 ± 10. Read More

Calcif Tissue Int 2022 04 28;110(4):464-474. Epub 2022 Jan 28.

Department of Diabetes and Endocrinology, Westmead Hospital, Sydney, NSW, Australia.

Central giant cell granuloma (CGCG) is a rare lesion of the jaw occurring in young adults and adolescents. Surgery, the traditional mainstay of therapy, is associated with significant morbidity. Denosumab, a humanised monoclonal antibody to RANKL, is effective in a related entity, giant cell tumour of bone (GCTB), but experience in the more indolent CGCG is limited. Read More

Front Immunol 2021 6;12:776913. Epub 2022 Jan 6.

Research and Evaluation, UK Health Security Agency (UKHSA), Salisbury, United Kingdom.

Non-human primate models of Tuberculosis (TB) are one of the most commonly used within the experimental TB field because they closely mimic the whole spectrum of disease progression of human TB. However, the early cellular interactions of the pulmonary granuloma are still not well understood. The use of this model allows investigation into the early interactions of cells within pulmonary granulomas which cannot be undertaken in human samples. Read More

Ann Pathol 2022 Apr 17;42(3):259-263. Epub 2022 Jan 17.

Service d'anatomie et de cytologie pathologiques, hôpital Trousseau, CHRU de Tours, avenue de la République à Chambray-Lès-Tours, 37044 Tours Cedex 9, France.

We report the case of a 10-year-old child with bilateral mandibular localization of a central giant cell granuloma occurring in the setting of Noonan syndrome. The histological appearance was classic with two intermigled components, one fibrous with non-atypical mononuclear cells, the other consisting of numerous osteoclast-like giant cells. This aspect is similar to that observed in the brown tumor as well as that of cherubism, which can also give multiple bone lesions. Read More

J Oral Pathol Med 2022 Feb 6;51(2):206-216. Epub 2022 Feb 6.

Department of Pathology, Biological Science Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.

Background: Central giant cell granulomas (CGCG) of the jaws are osteolytic lesions that may behave aggressively and respond poorly to surgery. Microscopically, in addition to giant cells, there is a mononuclear cell population composed of macrophage/monocytic cells and spindle-shaped cells of mesenchymal origin. Seventy two percent of these tumours harbour mutually exclusive TRPV4, KRAS and FGFR1 mutations. Read More

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096211070387

Department of Gastroenterology, SUNY Upstate Medical University, Syracuse, NY, USA.

Inflammatory pseudotumors of the liver are rare, non-neoplastic liver tumors. Due to the nonspecific clinical presentation, imaging features, and histopathological findings, they can mimic malignant tumors requiring invasive diagnostics. We present a case of a 61-year-old female patient with a history of type 2 diabetes mellitus, hypothyroidism, hyperlipidemia, and polymyalgia rheumatica who had initially presented with abdominal pain for 3 weeks. Read More

J Pharm Bioallied Sci 2021 Nov 10;13(Suppl 2):S1741-S1743. Epub 2021 Nov 10.

Departments of Oral Maxillofacial Surgery and Implantology, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

The giant cell granuloma is an identical reactive lesion which is mostly progressive in nature. The clinical behavior of these lesions varies from indolent to aggressive variant. The central form of giant cell granuloma involves the craniofacial bone, followed by long bones of hands and feet. Read More

Clin Implant Dent Relat Res 2022 Feb 4;24(1):133-137. Epub 2022 Jan 4.

Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging, Goldschleger School of Dental Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Purpose: The objectives were to characterize clinico-pathologically a large series of peri-implant peripheral giant cell granuloma (PGCG), and investigate the role of foreign material as a possible etiological factor.

Material And Methods: The study was retrospective, conducted on peri-implant specimens submitted for histology between 2005 and 2021.

Results: Three hundred and thirty-five peri-implant biopsies were retrieved, of which 52 (15. Read More

BMC Musculoskelet Disord 2021 Dec 6;22(1):1023. Epub 2021 Dec 6.

Department of Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136, Bologna, Italy.

Background: There is no standard treatment for giant cell tumors of the sacrum. We compared the outcomes and complications in patients with sacral giant cell tumors who underwent intralesional nerve-sparing surgery with or without (neo-) adjuvant therapies versus those who underwent non-surgical treatment (denosumab therapy and/or embolization).

Methods: We retrospectively investigated 15 cases of sacral giant cell tumors treated at two institutions between 2005 and 2020. Read More

Rinsho Ketsueki 2021 ;62(11):1598-1603

Department of Hematology, Sakai city Medical Center.

Localized thyroid diffuse large B-cell lymphoma stage with stage IE according to the Ann Arbor clinical staging system was diagnosed in a 75-year-old woman. The patient was treated with three courses of chemotherapy followed by radiotherapy. Positron emission tomography/computed tomography (PET-CT) using 2-deoxy-2-[F-18] fluoro-D-glucose (FDG) PET-CT was performed two months after chemotherapy showed increased FDG uptakes in systemic lymph nodes and gluteal muscles. Read More