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    3151 results match your criteria Peripheral Giant Cell Granuloma

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    Giant Cell Reparative Granuloma Mimicking Aneurysmal Bone Cyst in Proximal Phalanx of Toe.
    Malays Orthop J 2016 Mar;10(1):55-56
    Department of Orthopaedics, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan Malaysia.
    Giant Cell Reparative Granuloma (GCRG) of phalanx is uncommon. It is a benign osteolytic lesion but can be locally aggressive. GCRG has certain radiology and histological features that are similar to other giant cell lesions of the bone. Read More

    The effect of thymoquinone coating on adhesive properties of polypropylene mesh.
    BMC Surg 2017 Apr 17;17(1):40. Epub 2017 Apr 17.
    Department of Pathology, Kirikkale University Medical Faculty, Tahsin Duru Cad. No:14, Yenisehir, Yahsihan, 71450, Kirikkale, Turkey.
    Background: An incisional hernia is a common complication following abdominal surgery. Polypropylene mesh is frequently used in the repair of such defects and has nearly become the standard surgical treatment modality. Though they are very effective in reducing recurrence, mesh materials exhibit a strong stimulating effect for intraabdominal adhesion. Read More

    [Granulomatous periocular eruption].
    Ann Dermatol Venereol 2017 Apr 11. Epub 2017 Apr 11.
    Clinique universitaire de dermatologie, allergologie et photobiologie, CHU de Grenoble, boulevard de la Chantourne, 38700 La Tronche, France.
    Background: Herein, we report a case of atypical periorificial dermatitis in a patient that had been receiving treatment for some time for atopic dermatitis. The specific feature of this rash was its periocular predominance with no perioral involvement, its clinical aspect and its histological picture evocative of sarcoidosis.

    Patients And Methods: A 33-year-old man was being treated for a atopic dermatitis limited to the face and poorly responsive to dermal corticosteroids. Read More

    Annular Elastolytic Giant Cell Granuloma Successfully Treated With Adalimumab Subsequently Complicated by Drug-Induced Lupus.
    J Drugs Dermatol 2017 Feb;16(2):169-171
    We report a 51-year-old female with a 3-year history of recalcitrant annular elastolytic giant cell granuloma (AEGCG) who was effectively treated with the anti-tumor necrosis factor (TNF)-alpha antibody, adalimumab. Her disease was refractory to topical glucocorticoids, intralesional glucocorticoids, narrow-band ultraviolet light (UV)-B phototherapy and cyclosporine. During her treatment with adalimumab she developed a positive anti-nuclear-antibody and double-stranded-DNA antibody and her treatment was terminated. Read More

    Pseudotumoral form of soft tissue tuberculosis of the hand: six cases.
    Pan Afr Med J 2016 21;25:178. Epub 2016 Nov 21.
    Orthopedic surgery and Trauma Department, Maamouri Hospital, Nabeul, Tunisia.
    Musculoskeletal involvement is not uncommon in extra-pulmonary tuberculosis, but the localization in the soft tissue of the hand is very rare. Diagnosis is much more difficult because of the atypical location and non-specific symptoms. We report 6 cases of pseudotumoral form of soft tissue tuberculosis of the hand treated in our department during the past 12 years. Read More

    A Giant-Cell Lesion with Cellular Cannibalism in the Mandible: Case Report and Review of Brown Tumors in Hyperparathyroidism.
    Case Rep Dent 2017 9;2017:9604570. Epub 2017 Feb 9.
    Department of Surgical and Morphological Sciences, University of Insubria, ASST dei Sette Laghi, Unit of Oral Pathology, Dental Clinic, Varese, Italy.
    A small radiolucent area in the mandible was discovered in a 58-year-old woman with no oral complaints. The patient's history included only hypertension. The lesion was considered as an inflammatory cyst and was enucleated. Read More

    [Giant cell reparative granuloma of the metacarpal bone : Diagnostic difficulties].
    Unfallchirurg 2017 Mar 3. Epub 2017 Mar 3.
    Klinik für Unfallchirurgie, Klinikum Passau, Innstraße 76, 94032, Passau, Deutschland.
    Giant cell reparative granuloma (GCRG) is benign, non-tumorous granulation tissue. It mainly arises in the jaw bone and occasionally in the hand and foot. Because of the high rate of recurrence, wide surgical resection and autologous bone grafting are recommended. Read More

    Osteolysis of the Greater Trochanter Caused by a Foreign Body Granuloma Associated with the Ethibond® Suture after Total Hip Arthroplasty.
    Case Rep Orthop 2017 31;2017:6082302. Epub 2017 Jan 31.
    Akita Hip Research Group (AHRG), Akita, Japan; Department of Orthopedic Surgery, Akita University Graduate School of Medicine, Akita, Japan.
    The present case shows a case of progression of osteolysis of the greater trochanter caused by a foreign body granuloma associated with the number 5 Ethibond suture in cementless THA with the direct lateral approach that was completely healed by removal of the Ethibond suture. A 55-year-old Japanese woman with secondary osteoarthritis caused by acetabular dysplasia underwent left cementless THA with the direct lateral approach. After setting of the total hip prosthesis, the gluteus medius muscle and vastus lateralis muscle were reattached to the greater trochanter through two bone tunnels using number 5 Ethibond EXCEL sutures. Read More

    Actinic Granuloma Annulare With Scarring and Open Comedones.
    Am J Dermatopathol 2017 Feb 14. Epub 2017 Feb 14.
    *Department of Dermatology, Medical School, University of São Paulo, São Paulo, Brazil; and †Department of Pathology, Hospital Obrero, La Paz, Bolivia.
    Actinic granuloma and annular elastolytic giant cell granuloma are variants of granuloma annulare affecting, respectively, sun-exposed and sun-covered skin sites on where, besides classical findings, abundant elastophagocytosis is observed. Here, we report a case of exuberant actinic granuloma annulare that, in addition to extensive scarring, showed multiple overlying open comedones. Markedly dilated follicular infundibula filled with compact masses of laminated keratinous material were observed in proximity to dermal inflammation composed of many histiocytes and multinucleated giant cells in close association with degenerated elastic fibers and abundant elastophagocytosis. Read More

    Spectrum and clinical variants of giant cell elastolytic granuloma.
    Int J Dermatol 2017 Feb 27. Epub 2017 Feb 27.
    Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan.
    Background: Giant cell elastolytic granuloma, also known as annular elastolytic giant cell granuloma or actinic granuloma, is histologically characterized by elastophagocytosis. Recent studies have revealed various clinical presentations in both sun-exposed and non-sun-exposed areas.

    Objectives: To clarify clinical characteristics based on case series observation. Read More

    Histological evaluation of the possible transformation of peripheral giant cell granuloma and peripheral ossifying fibroma: A preliminary study.
    Indian J Pathol Microbiol 2017 Jan-Mar;60(1):15-20
    Department of Pathology, Gülhane Military Medical Academy, Ankara, Turkey.
    Aims: The objective of this study is to describe shared morphological features of peripheral giant cell granuloma (PGCG) and peripheral ossifying fibroma (POF) in detail and discuss the possible relationship between them.

    Materials And Methods: Ten intermediate cases with features resembling to both POF and PGCG were selected and type 3 and 1 collagen immunostainings were performed for evaluation of the connective tissue maturation. Immunohistochemical staining percentage (SP) for stromal cells in the slides of POF and PGCG counterparts of intermediate lesions was scored as 1 when the SP was above 10%, 2 when the SP was above 25%, 3 when the SP was above 50% and 4 when the SP was above 75%. Read More

    Mycolates of Mycobacterium tuberculosis modulate the flow of cholesterol for bacillary proliferation in murine macrophages.
    J Lipid Res 2017 Apr 13;58(4):709-718. Epub 2017 Feb 13.
    Laboratory of Molecular Immunology, Department of Biomedical Molecular Biology, Ghent University, Ghent Zwijnaarde 9052, Belgium
    The differentiation of macrophages into lipid-filled foam cells is a hallmark of the lung granuloma that forms in patients with active tuberculosis (TB). Mycolic acids (MAs), the abundant lipid virulence factors in the cell wall of Mycobacterium tuberculosis (Mtb), can induce this foam phenotype possibly as a way to perturb host cell lipid homeostasis to support the infection. It is not exactly clear how MAs allow differentiation of foam cells during Mtb infection. Read More

    Age and Expression of CD163 and Colony-Stimulating Factor 1 Receptor (CD115) Are Associated With the Biological Behavior of Central Giant Cell Granuloma.
    J Oral Maxillofac Surg 2017 Jan 9. Epub 2017 Jan 9.
    Associate Professor and Head, Department of Oral Pathology and Oral Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
    Purpose: Central giant cell granulomas (CGCGs) are clinically classified as nonaggressive (nA-CGCGs) and aggressive (A-CGCGs). However, histopathologically, all lesions feature spindle mononuclear cells (MCs) and multinuclear giant cells (GCs) in a hemorrhage-rich stroma. We aimed to investigate the presence of cells with a monocyte- or macrophage-related phenotype and, together with clinical variables, to examine their predictive potential for the biological behavior of CGCGs. Read More

    Patients with benign hand tumors are indicated for surgery according to patient-rated outcome measures.
    J Plast Reconstr Aesthet Surg 2017 Apr 9;70(4):487-494. Epub 2017 Jan 9.
    Department of Hand Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
    Introduction: This study assessed the treatment outcomes of upper extremity benign tumors using the patient-rated outcome measures of Hand20 questionnaire.

    Methods: In total, 304 patients who underwent surgery for benign bone and soft tissue tumors of the upper limb were included. Tumors were classified into three size groups: <1 cm, 1-3 cm, and >3 cm. Read More

    Radiologic-Pathologic Correlation of Primary and Secondary Cardiomyopathies: MR Imaging and Histopathologic Findings in Hearts from Autopsy and Transplantation.
    Radiographics 2017 Jan 27:160082. Epub 2017 Jan 27.
    From the Departments of Radiology (H.H., Y.M., M.H., H.N.) and Pathology (H.H., H.I.U.), National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, Japan; Departments of Diagnostic Radiology (F.K.), Cardiology (S.N.), and Cardiovascular Surgery (A.I.), Saitama Medical University International Medical Center, Hidaka, Japan; Department of Radiology, Tenri Hospital, Tenri, Japan (K.U.); and Department of Radiology, Kobe University, Kobe, Japan (K.S.).
    Cardiac magnetic resonance (MR) imaging with late gadolinium enhancement (LGE) is used to detect and assess the myocardial damage seen with a variety of cardiomyopathies. Gadolinium-based contrast material accumulates in the expanded interstitial space of the myocardium. Areas with LGE correspond to replacement fibrosis, fibrofatty change, epithelioid granuloma, inflammatory cell infiltration, cardiomyocyte necrosis, and amyloid deposition-conditions that represent a focal increase in interstitial space. Read More

    Evaluation of mast cell counts and microvessel density in reactive lesions of the oral cavity.
    J Dent Res Dent Clin Dent Prospects 2016 21;10(4):241-246. Epub 2016 Dec 21.
    Postgraduate Student, Biotechnology Research Center and Department of Orthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
    Background. Reliable immunohistochemical assays to assess the definitive role of mast cells (MCs) and angiogenesis in the pathogenesis of oral reactive lesions are generally not available. The aim of the present study was to evaluate mast cell counts (MCC) and microvessel density (MVD) in oral reactive lesions and determine the correlation between MCC and MVD. Read More

    A central giant cell granuloma in posterior part of maxilla-A case report.
    Int J Surg Case Rep 2017 17;30:222-225. Epub 2016 Nov 17.
    Department of the Oral & Maxillofacial Surgery, kalka Dental College & Hospital, Meerut India College of Medicine & J.N.M. Hospital, West Bengal India.
    Introduction: Central Giant Cell Granuloma (CGCG) is an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of hemorrhage, aggregations of multinucleated giant cells and occasionally trabeculae of woven bone1.

    Presentation Of Case: we are presenting a case of Central Giant Cell Granuloma on Maxilla. Extra oral examination revealed a diffuse swelling on the left side of face causing slight obliteration of nasio - nasolabial labial fold resulting in facial asymmetry & Intraoral examination shows a purple expansile mass in the region of upper left 26, 27 and 28 edentulous areas. Read More

    Pharmacological and surgical therapy for the central giant cell granuloma: A long-term retrospective cohort study.
    J Craniomaxillofac Surg 2017 Feb 9;45(2):232-243. Epub 2016 Dec 9.
    Department of Oral and Maxillofacial Surgery (Head: Prof. J. de Lange), Academic Medical Center, Academic Center Dentistry Amsterdam and University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. Electronic address:
    Purpose: This is a retrospective cohort study of patients with a central giant cell granuloma (CGCG) treated at a single center to assess and compare the different surgical and non-surgical approaches.

    Material And Methods: A cohort with a single histologically proven non-syndrome-related CGCG was selected and reviewed. Patients were allocated to group I (surgery), group II (pharmacotherapy), and group III (pharmacotherapy and surgery). Read More

    Inhalation and Oropharyngeal Aspiration Exposure to Rod-Like Carbon Nanotubes Induce Similar Airway Inflammation and Biological Responses in Mouse Lungs.
    ACS Nano 2017 Jan 11;11(1):291-303. Epub 2017 Jan 11.
    Institute of Environmental Medicine (IMM), Karolinska Institutet , Stockholm 171 77, Sweden.
    Carbon nanotubes (CNTs) have the potential to impact technological and industrial progress, but their production and use may, in some cases, cause serious health problems. Certain rod-shaped multiwalled CNTs (rCNTs) can, in fact, induce severe asbestos-like pathogenicity in mice, including granuloma formation, fibrosis, and even cancer. Evaluating the comparability between alternative hazard assessment methods is needed to ensure fast and reliable evaluation of the potentially adverse effects of these materials. Read More

    Peripheral Giant Cell Granuloma in a Child Associated with Ectopic Eruption and Traumatic Habit with Control of Four Years.
    Case Rep Dent 2016 24;2016:6725913. Epub 2016 Nov 24.
    Master's Program in Integrated Dental Sciences, University of Cuiabá, Cuiabá, MT, Brazil.
    Peripheral giant cell granuloma (PGCG) is a nonneoplastic lesion that may affect any region of the gingiva or alveolar mucosa of edentulous and toothed areas, preferentially in the mandible and rarely occurring in children. This report describes the clinical and histopathological findings of a PGCG diagnosed in the maxilla of a 9-year-old boy associated with a tooth erupting improperly and a traumatic habit. The patient did not present anything noteworthy on extraoral physical examination or medical history, but the habit of picking his teeth and "poking" the gingiva. Read More

    IL-12Rβ1 defect presenting with massive intraabdominal lymphadenopathy due to Mycobacterium intracellulare: A case report.
    Asian Pac J Allergy Immunol 2016 Dec 12. Epub 2016 Dec 12.
    Marmara University School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, Turkey.
    Infections due to non-tuberculous mycobacteria species are problematic for immunodeficient individuals. Mendelian susceptibility to mycobacterial diseases (MSMD) defines a group of genetic defects affecting cellular interactions and the interferon (IFN)-γ pathway. Patients with MSMD may present with a disseminated infection resulting from the Bacillus Calmette-Guerin vaccine, Mycobacterium tuberculosis complex, environmental nontuberculous mycobacteria or Salmonella species. Read More

    Palatal Swelling: A Diagnostic Enigma.
    Case Rep Dent 2016 16;2016:1945907. Epub 2016 Nov 16.
    Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Sri Ramachandra University, Tamil Nadu, India.
    Giant cell tumor (GCT) of bone is a giant-cell-rich bony lesion associated with abundant multinucleated osteoclast-type giant cells. It is a primary neoplasm of bone with characteristic clinical, radiological, and pathological features. It is an expansive and lytic lesion without periosteal reaction and prominent peripheral sclerosis. Read More

    Primary Tuberculosis of Cervix: A Coincidental Finding.
    J Reprod Infertil 2016 Oct-Dec;17(4):247-249
    Department of Pathology, North Eastern Indira, Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.
    Background: 95% of Tuberculosis (TB) of the female genital tract (FGT) is located in tissues other than the cervix. A rare case of primary TB of the cervix which was diagnosed coincidently in a patient of endometrioma was reported in this study.

    Case Presentation: A 34 year old nullipara, a diagnosed case of endometrioma had a small cervical growth. Read More

    IL-4 induces the formation of multinucleated giant cells and expression of β5 integrin in central giant cell lesion.
    Med Oral Patol Oral Cir Bucal 2017 Jan 1;22(1):e1-e6. Epub 2017 Jan 1.
    Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
    Background: It is now well established that IL-4 has a central role in the development of monocytes to multinucleated giant cells (MGCs) by inducing the expression of integrins on the surface of monocytes. The aim of this study was to investigate the potential role of IL-4 in induction of β5 integrin expression in the peripheral blood samples of patients with giant cell granuloma.

    Material And Methods: Monocytes were isolated from peripheral blood samples of patients with central giant cell granuloma (CGCG) and healthy controls using human Monocyte Isolation Kit II. Read More

    Differential Cytokine Gene Expression in Granulomas from Lungs and Lymph Nodes of Cattle Experimentally Infected with Aerosolized Mycobacterium bovis.
    PLoS One 2016 30;11(11):e0167471. Epub 2016 Nov 30.
    Infectious Bacterial Diseases of Livestock Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, Iowa, United States of America.
    The hallmark lesion of tuberculosis in humans and animals is the granuloma. The granuloma represents a distinct host cellular immune response composed of epithelioid macrophages, lymphocytes, and multinucleated giant cells, often surrounding a caseous necrotic core. Within the granuloma, host-pathogen interactions determine disease outcome. Read More

    Multifocal tenosynovial giant cell tumors in a child with Noonan syndrome.
    Pediatr Radiol 2017 Mar 23;47(3):361-365. Epub 2016 Nov 23.
    Department of Pathology, Medical College of Wisconsin & Children's Hospital of Wisconsin, Milwaukee, WI, USA.
    Noonan syndrome is a genetic disorder with variable expression of distinctive facial features, webbed neck, chest deformity, short stature, cryptorchidism and congenital heart disease. The association of Noonan syndrome and giant cell granulomas of the mandible is widely reported. However, Noonan syndrome may also be associated with single or multifocal tenosynovial giant cell tumors, also referred to as pigmented villonodular synovitis. Read More

    Filariasis in Mandible and Maxilla: A Rare Entity-First Report of a Case.
    J Oral Maxillofac Surg 2017 Apr 31;75(4):769.e1-769.e4. Epub 2016 Oct 31.
    Tutor, Institute of Dental Sciences, Bhubaneswar, India.
    Wuchereria bancrofti, Brugia malayi, and Brugia timori, categorized as nematodes, are responsible for causing lymphatic filariasis. Even though it can affect individuals of all age groups and both genders, it predominantly affects people of low socioeconomic strata. The filarial worms dwell in the subcutaneous tissues and lymphatics of human hosts. Read More

    "Giant cell reparative tumor: An exceptional differential diagnosis for a lytic lesion of the temporal bone".
    Neurochirurgie 2016 Dec 17;62(6):332-335. Epub 2016 Nov 17.
    Department of Neurosurgery, hôpital Nord, CHU AP-HM, 13015 Marseille, France. Electronic address:
    Background And Importance: Giant cell reparative granuloma is a very rare benign osteolytic lesion. It typically arises in the mandible and rarely involves the skull.

    Clinical Presentation: A 25-year-old male was admitted in August 2002 for a painless left preauricular mass of several months duration. Read More

    Enhanced formation of giant cells in common variable immunodeficiency: Relation to granulomatous disease.
    Clin Immunol 2017 Feb 14;175:1-9. Epub 2016 Nov 14.
    Department of Immunology, University College London, Royal Free Hospital NHS Trust, Pond Street, Hampstead NW3 2QG, London.
    Peripheral monocytes from patients with common variable immunodeficiency (CVID) had on average a 2 fold greater tendency to form giant cells in medium without additional cytokines. Giant cell formation was faster and 3 to 5 fold higher in most CVID cells compared to normal. Addition of IL4, GMCSF, IFNγ, TNFa and both T cell and monocyte conditioned media promoted monocyte fusion of some CVID individuals over 5 fold the normal average level, with combinations of cytokines and monokines acting synergistically. Read More

    Acute alloxan toxicity causes granulomatous tubulointerstitial nephritis with severe mineralization.
    J Toxicol Pathol 2016 Oct 27;29(4):261-264. Epub 2016 May 27.
    Laboratory of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
    Alloxan had been recognized as having a direct nephrotoxic effect different from its diabetogenic action. We encountered previously unreported granulomatous tubulointerstitial nephritis with severe luminal and interstitial mineralization in one diabetic rat after one week of alloxan administration. Histopathologically, many dilated and occluded proximal and distal tubules were segmentally observed in the cortex and outer medulla. Read More

    A recurrent central giant cell granuloma in a young patient and orthodontic treatment: a case report.
    J Orthod 2016 Dec 22;43(4):306-313. Epub 2016 Sep 22.
    a Maxillofacial Department , Royal Surrey County Hospital Foundation Trust , Guildford, Surrey , UK.
    Central giant cell granuloma (CGCG) is an uncommon benign intraosseous lesion of the jaw, found predominantly in children and young adults below 30 years of age. The purpose of this article was to present a summary of the current literature and a case report of an 11-year-old boy diagnosed with an aggressive CGCG involving the anterior maxilla that was removed in 2004 and subsequently recurred almost 3 years later in 2006. The presenting features of the patient and the effect of combined surgical and orthodontic treatment for this condition are discussed. Read More

    Multifocal Central Giant Cell Granuloma - A Case Report.
    Iran J Pathol 2016 ;11(3):276-280
    Dept. of Oral & Maxillofacial Pathology and Microbiology, Dr D Y Patil Dental College & Hospital, Sector 7, Nerul, Navi Mumbai, Maharashtra, India.
    Central giant cell granuloma is a benign, aggressive neoplasm composed of multinucleated giant cells that almost exclusively occurs in the jaws though extra- gnathic incidence is rare. Multifocal CGCGs of the jaws are very rare and suggestive of systemic diseases such as hyperparathyroidism, an inherited syndrome such as Noonan- like multiple giant cell lesion syndrome or other disorders.Very few cases of multifocal CGCGs in the jaws without any concomitant systemic disease have been reported. Read More

    Efficacy of Ethanolamine Oleate Sclerotherapy in Treatment of Peripheral Giant Cell Granuloma.
    J Oral Maxillofac Surg 2016 Nov 30;74(11):2200-2206. Epub 2016 Apr 30.
    Assistant Professor, Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt. Electronic address:
    Purpose: The aim of this study was to evaluate the efficacy of ethanolamine oleate (EO) sclerotherapy in the treatment of peripheral giant cell granuloma.

    Patients And Methods: This study included 24 patients presenting with PGCGs greater than 2 cm in diameter. Definitive diagnosis was confirmed after histopathologic examination of incisional biopsy specimens. Read More

    The role of monocytes in ANCA-associated vasculitides.
    Autoimmun Rev 2016 Nov 1;15(11):1046-1053. Epub 2016 Aug 1.
    Renal and Vascular Inflammation Section, Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK. Electronic address:
    The anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) are a heterogeneous group of diseases causing inflammation in small blood vessels and linked by the presence of circulating ANCA specific for proteinase 3 (PR3) or myeloperoxidase (MPO). These antigens are present both in the cytoplasmic granules and on the surface of neutrophils, and the effect of ANCA on neutrophil biology has been extensively studied. In contrast, less attention has been paid to the role of monocytes in AAV. Read More

    [Giant inflammatory pseudotumor of the cranial base].
    Neurocirugia (Astur) 2016 Nov - Dec;27(6):291-295. Epub 2016 Jul 12.
    Servicio de Anatomía Patológica, Hospital Universitario Ramón y Cajal, Madrid, España.
    The inflammatory pseudotumour (IPT) is a non-neoplastic entity of unknown origin, and is characterised by a proliferation of connective tissue and a polyclonal inflammatory infiltrate. Central nervous system involvement is uncommon, and usually represents a diagnostic and therapeutic challenge even for the experienced clinician. This reports deals with the case of a 56year-old woman diagnosed with a giant, infiltrating mass centred in the left cavernous sinus, who had a rapid clinical and radiological response to steroid therapy. Read More

    Coexisting sarcoidal granulomatous inflammation and diffuse tenosynovial giant cell tumor of the knee after a total knee replacement: a case report.
    Skeletal Radiol 2016 Dec 7;45(12):1735-1740. Epub 2016 Oct 7.
    Department of Pathology, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
    Sarcoidosis is a systemic inflammatory disorder characterized by non-caseating granulomas, predominantly involving lung, mediastinal lymph nodes and other organs. Synovium involvement is infrequent, and as far as we know, involvement of a periprosthetic membrane has not been reported in the English literature. Intra-articular diffuse tenosynovial giant cell tumor ("conventional diffuse pigmented villonodular synovitis") is an uncommon, locally aggressive neoplasm with few previous case reports in which it arose in periprosthetic tissues after knee arthroplasty. Read More

    Multinucleated giant cell cytokine expression in pulmonary granulomas of cattle experimentally infected with Mycobacterium bovis.
    Vet Immunol Immunopathol 2016 Nov 31;180:34-39. Epub 2016 Aug 31.
    Infectious Bacterial Diseases of Livestock Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, United States.
    Regardless of host, pathogenic mycobacteria of the Mycobacterium tuberculosis complex such as Mycobacterium bovis, induce a characteristic lesion known as a granuloma, tubercle or tuberculoid granuloma. Granulomas represent a distinct host response to chronic antigenic stimuli, such as foreign bodies, certain bacterial components, or persistent pathogens such as M. bovis. Read More

    Spontaneous Resolution of a Central Giant Cell Granuloma in a Child After an Incisional Biopsy: A Five-year Follow-up.
    J Dent Child (Chic) 2016 ;83(2):102-5
    Department of Stomatology and Oral Radiology, School of Dentistry, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.
    A central giant cell granuloma (CGCG) is typically regarded as a benign lesion with osteoclastic activity. Treatment often involves surgical procedures that may cause deformities; however, minimally invasive approaches have been suggested for treating pediatric patients. We report a case of CGCG of the mandible in a 13-year-old boy who presented with a well-defined radiolucent area in the anterior mandible that was initially detected in a radiographic examination for orthodontic purposes. Read More

    Histopathological findings in wild Nutrias (Myocastor coypus) with Capillaria hepatica infection.
    J Vet Med Sci 2017 Jan 28;78(12):1887-1891. Epub 2016 Aug 28.
    Institute of Animal Medicine, Gyeongsang National University, Jinju, Republic of Korea.
    Capillaria hepatica is a zoonotic nematode that uses rodents and other mammals as hosts, especially rats and mice, and causes hepatic granuloma and eventually fibrosis/cirrhosis. However, C. hepatica infection in nutria, a large semiaquatic rodent, has rarely been reported, and histopathologic features of the infection have not been described in detail. Read More

    The effect of clinical features and glucocorticoids on biopsy findings in giant cell arteritis.
    BMC Musculoskelet Disord 2016 Aug 24;17(1):363. Epub 2016 Aug 24.
    Department of Clinical Sciences, Rheumatology, Lund University, Malmö, Sweden.
    Background: To investigate the effect of baseline clinical characteristics and glucocorticoid treatment on temporal artery biopsy (TAB) findings in patients with giant cell arteritis (GCA).

    Methods: Individuals who developed GCA after inclusion in two population-based health surveys were identified through linkage to the local and the national patient registers. In addition, other patients diagnosed with GCA at the Departments of Internal Medicine and Rheumatology at an area hospital were included. Read More

    Granuloma annulare: Pathogenesis, disease associations and triggers, and therapeutic options.
    J Am Acad Dermatol 2016 Sep;75(3):467-79
    Department of Dermatology, Perelman School of Medicine at the Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    Granuloma annulare (GA) represents a cutaneous reaction pattern of unknown cause with a variety of previously described potential disease associations and triggers. This review attempts to synthesize the available data regarding potential etiopathogenesis, reviews the available data on potential GA disease associations and work-up indicated for patients with GA, and discusses potential inciting triggers. In the final part, this article describes the available treatments options and supporting data, and provides a framework for approaching management of patients with GA. Read More

    Granuloma annulare: Clinical and histologic variants, epidemiology, and genetics.
    J Am Acad Dermatol 2016 Sep;75(3):457-65
    Department of Dermatology, Perelman School of Medicine at the Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    Granuloma annulare (GA) is a poorly understood condition characterized by a set of clinical morphologic variants with 2 predominant histopathologic patterns of inflammation. This review provides a comprehensive overview of the available information about the clinical variants and histopathologic features, current epidemiologic data, and potential genetic underpinnings of GA. Much of the current understanding of GA is based on retrospective studies, case series, and case reports; this review aims to synthesize the available information and present it clearly for practicing dermatologists. Read More

    Defining a new aggressiveness classification and using NFATc1 localization as a prognostic factor in cherubism.
    Hum Pathol 2016 Dec 3;58:62-71. Epub 2016 Aug 3.
    INSERM, UMRS 1138, Centre de Recherche de Cordeliers, Molecular Oral Pathology, 75006 Paris, France; Université Paris Descartes, 75006 Paris, France; APHP, Necker Enfants Malades, Service de Chirurgie Maxillo-Faciale et Plastique, 75015 Paris, France; APHP, CRMR des Malformations Rares de la Face et de la Cavité Buccale, 75015 Paris, France.
    Cherubism is a rare genetic disease characterized by bilateral giant cell reparative granuloma of the jaws consisting of a fibrotic stroma with giant multinucleated cells (GMCs) and osteoclastic features. Cherubism severity is highly variable, and recurrence after surgery is the most important risk. Currently, there are no prognostic indicators. Read More

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