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Materials (Basel) 2020 Jul 1;13(13). Epub 2020 Jul 1.

Clinical Microbiology Department, IIS-Fundacion Jimenez Diaz, UAM, 28040 Madrid, Spain.

The aim of this study was to evaluate the effectiveness of a moxifloxacin-loaded organic-inorganic sol-gel (A50) by locally preventing the catheter-related bloodstream infection (CRBSI) provoked by () and the effect resulting from its hydrolytic degradation on coagulation by using a rabbit in-vivo model. A50 coating can completely inhibit growth and would locally prevent CRBSI provoked by . None of the coagulation blood parameters showed a significant difference constant over time between the control catheter group and the A50-coated catheter group, despite the visible silica release resulting from physiological A50 sol-gel degradation detected in serum at least during the first week. Read More

J Oral Maxillofac Surg 2020 Jun 10. Epub 2020 Jun 10.

Assistant Professor of Surgery and Residency Program Director, Department of Oral and Maxillofacial Surgery, Parkland/UT Southwestern, Dallas, TX.

An association between granulocyte colony-stimulating factor therapy (G-CSFT) in patients with glycogen storage disease type Ib (GSDIb) and the development of giant cell lesions of the maxillofacial complex has emerged. We have reported, to the best of our knowledge, the fourth case of giant cell granuloma (GCG) in a patient with GSDIb undergoing G-CSFT. GSDIb can present with hypoglycemia, hypertriglyceridemia, and neutropenia. Read More

Insights Imaging 2020 Jun 29;11(1):80. Epub 2020 Jun 29.

Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Spinal osseous neoplasms are frequently encountered and can be challenging when present as solitary lesions. Familiarity with the range of benign and malignant spinal pathology can help the radiologist formulate a comprehensive differential diagnosis. This article focuses on the spectrum of extradural spinal tumors, accounting for the majority of primary spinal tumors, by comparing the epidemiology, pathophysiology, clinical presentation, and characteristic imaging appearance of these lesions. Read More

Mod Pathol 2020 Jun 26. Epub 2020 Jun 26.

Department of Pathology, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain.

The precise nature of the local immune responses in lung tuberculosis (TB) granulomas requires a comprehensive understanding of their environmental complexities. At its most basic level, a granuloma is a compact, organized immune aggregate of macrophages surrounded by myeloid, B and T cells. We established two complementary multiplex immunolabeling panels to simultaneously evaluate the myeloid and lymphocytic contexture of 14 human lung TB granulomas in formalin-fixed paraffin-embedded tissue samples. Read More

J Oral Maxillofac Pathol 2020 Jan-Apr;24(1):76-80. Epub 2020 May 8.

Department of Oral Pathology and Microbiology, Bareilly International University, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.

Context: Focal fibrous hyperplasia, peripheral ossifying fibroma, pyogenic granuloma, peripheral giant cell granuloma, giant cell fibroma and focal reactive overgrowth (FROGs) are one of the foremost numerous benign soft-tissue growths in the oral cavity. Chronic irritation or trauma is with identified as the causative aspect. It may develop up to few centimeters in diameter, pedunculated or sessile and may arise on the gingiva or buccal mucosa. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Jul 31;130(1):78-84. Epub 2020 May 31.

Professor and Head, Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Mumbai, India.

Objectives: This study aimed to evaluate and compare the immunohistochemical expression of OCT-4 and SOX-2 and to determine their use in differentiating giant cell tumor (GCT) from central giant cell granuloma (CGCG) and peripheral giant cell granuloma (PGCG).

Study Design: Formalin-fixed, paraffin-embedded tissue blocks of 10 histopathologically diagnosed cases of GCT, CGCG, or PGCG were examined for anti-OCT-4 and anti-SOX-2 antibodies. Nuclear staining of stromal mononuclear cells and multinucleated giant cells was considered positive for OCT-4 and SOX-2 expression. Read More

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):644-646

Department of Pathology, East District of Suzhou Municipal Hospital, Suzhou 215000, China.

Acta Otorrinolaringol Esp 2020 May 26. Epub 2020 May 26.

Hospital General Universitario Gregorio Marañón, Madrid, España.

Ann Diagn Pathol 2020 May 21;47:151536. Epub 2020 May 21.

Oral and Dental Surgery Unit, Rashid Hospital, Dubai, United Arab Emirates.

Langerhans cell histiocytosis (LCH) is a bone marrow-derived immature myeloid dendritic cell proliferative disorder with diverse clinical manifestations commonly involves bone, skin, lymph node and lung. Oral involvement is uncommon. Intraoral lesions can be the first sign of either a localized LCH or clinically undiagnosed systemic LCH, predates systemic manifestations of LCH, or an early indicator of recurrence in known cases. Read More

J Clin Neurosci 2020 May 14. Epub 2020 May 14.

Service de Radiologie, Institut Mohamed Kassab d'orthopédie, Ksar Said, Tunisia.

Brucellar spondylodiscitis (BS) is the most common form of musculoskeletal brucellosis. The isolation of Brucella spp from blood, other body fluids or tissue cultures is the gold standard for definitive diagnosis of BS. BS shows a large histopathological spectrum of lesions with non-specific and granulomatous forms, and its histopathological features are not widely reported. Read More

Front Cell Infect Microbiol 2020 29;10:189. Epub 2020 Apr 29.

Aix-Marseille Univ, IRD, Assistance Publique-Hôpitaux de Marseille (APHM), MEPHI, IHU-Méditerranée Infection, Marseille, France.

Granulomas are compact structures formed in tissues by the immune system in response to aggressions. The formation of granulomas using circulating mononuclear cells is an innovative method to easily assess the immune response of patients. Monitoring the efficiency of mononuclear cells from patients to form granulomas would help improve their therapeutic management. Read More

Ital J Pediatr 2020 May 11;46(1):58. Epub 2020 May 11.

Pediatric Endocrinology Unit, Department of Public Health and Pediatric Sciences, Regina Margherita Children's Hospital, University of Turin, Turin, Italy.

Background: Jaffe-Campanacci syndrome is characterized by multiple non-ossifying fibromas, café-au-lait macules and giant cell granulomas of the jaw. Even if the association between all these peculiar features and neurofibromatosis type 1 have been described, it has not yet been clarified whether Jaffe-Campanacci syndrome represents a distinct entity or it can be regarded as a neurofibromatosis type 1 subtype.

Case Presentation: The patient here described is a young boy, who fulfilled the clinical diagnostic criteria for both syndromes. Read More

Clin Implant Dent Relat Res 2020 Jun 7;22(3):366-372. Epub 2020 May 7.

Oral Pathology Master Programme, Oral and Maxillofacial Pathology Unit, Dental Clinic Service, Department of Stomatology II, University of the Basque Country (UPV/EHU), Leioa, Spain.

Background: Peri-implantitis is the inflammatory process, which most commonly affects the therapy with dental implants. However, there are other reactive and neoplastic entities, mainly benign but also malignant, which also take place in the peri-implant mucosa. There is little information about the histopathological analysis of these peri-implant inflammatory diseases. Read More

Acta Derm Venereol 2020 Jun 15;100(13):adv00182. Epub 2020 Jun 15.

Department of Dermatology, Aichi Medical University, 480-1195 Nagakute, Japan. E-mail:

Pathol Int 2020 Apr 27. Epub 2020 Apr 27.

Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

The solid variant of aneurysmal bone cyst (SVABC) is very uncommon and frequently misdiagnosed. We reevaluated and summarized the clinicopathologic features of 17 SVABCs and further discussed the use of this nomenclature to differ SVABCs from extragnathic giant cell reparative granuloma (GCRG) in the setting of the USP6 rearrangement era. The immunohistochemical markers included α-SMA, SATB2, AE1/AE3, Ki67, S100, CD68 and P63. Read More

Ann Diagn Pathol 2020 Apr 20;46:151526. Epub 2020 Apr 20.

Dentistry and Health Postgraduate Program, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil; Laboratory of Oral and Maxillofacial Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil. Electronic address:

Objective: This study seeks to investigate immunohistochemical parameters that could distinguish non-aggressive Central giant cell granuloma (CGCG) from aggressive CGCG, two groups of lesions which differ in their clinical and radiographic features and prognosis.

Material And Methods: 12 cases of non-aggressive CGCG and 11 cases of aggressive CGCG were investigated and associated the immunohistochemical expression of macrophages (CD68 and CD163), blood vessels (CD34 and CD105), lymphatic vessels (D2-40) and regulator proteins (p63 and Ki-67). Clinical and radiographic features were also studied. Read More

Medicine (Baltimore) 2020 Apr;99(15):e19788

Department of Radiology, The Third Hospital of Hebei Medical University, Shijiazhuang Hebei Province, China.

Rationale: Idiopathic thrombocytopenic purpura (ITP) is the condition of having a low platelet count of unknown causes and is a poorly understood acquired hemorrhagic disease involving destruction of platelets in the reticuloendothelial system induced by antiplatelet antibodies. Patients with ITP can have traumatic intra-articular, intraosseous or soft tissue hemorrhage which may present as a rare intraosseous pseudotumor on medical imaging.

Patient Concerns: A 30-year old male patient had complaint of pain in the right leg for 1 year. Read More

Laser Ther 2019 Dec;28(4):291-297

Department of Oral Pathology and Microbiology, Govt. College of Dentistry, Indore, Madhya Pradesh (India) 452001.

Background: Focal reactive gingival overgrowths (FRGO) are a common observation in a clinical dental practice that may occur in response to external and internal chronic stimuli in form of fibrous connective tissue lesions in the oral mucosa. Gingiva is the most commonly involved site of oral reactive lesions. For the confirmed diagnosis of FRGO not only clinical, but the histopathological presentation of the lesion plays a vital role. Read More

J Neuroophthalmol 2020 Mar 31. Epub 2020 Mar 31.

Faculty of Medicine (PN), University of Toronto, Toronto, Canada; Department of Ophthalmology and Vision Sciences (JAM), University of Toronto, Toronto, Canada; and Division of Neurology (JAM), Department of Medicine, University of Toronto, Toronto, Canada.

J Eur Acad Dermatol Venereol 2020 Mar 26. Epub 2020 Mar 26.

Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, US.

Objectives: Evaluate the efficacy of sulfasalazine in treating GA, AEGCG, and IGD.

Methods: Sixteen patients were identified with granulomatous disease who were treated with sulfasalazine between September 2015 and September 2019. Outcomes were based on patients' and providers' subjective evaluations. Read More

Head Neck Pathol 2020 Mar 24. Epub 2020 Mar 24.

Oral Pathology Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.

Central odontogenic fibroma is a rare benign odontogenic tumor that relies on clinical-radiographic-histological correlation to reach its diagnosis, especially its rare variants. Of these rare types is the coexistence of giant cell granuloma-like lesion, with the characteristic odontogenic epithelial rests. The presented case is a 33 years old female complaining of asymptomatic mandibular bony swelling. Read More

Imaging Sci Dent 2020 Mar 17;50(1):53-64. Epub 2020 Mar 17.

Division of Oral and Maxillofacial Radiology, Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada.

Purpose: The aim of this study was to determine the prevalence of incidental findings (IFs) on digital dental panoramic radiographs (DPRs) of asymptomatic patients attending a general dental practice.

Materials And Methods: This was a retrospective study of 6,252 consecutive digital (photostimulatable phosphor) DPRs of patients who visited a Canadian general dental practice for a complete new patient examination. The IFs were grouped into dental-related anomalies, radiopacities and radiopacities in the jaws, changes in the shape of the condyles, and other findings in the jaws, such as tonsilloliths and mucosal antral pseudocysts. Read More

J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S59-S66. Epub 2020 Feb 28.

Department of Endocrinology and Diabteology, Kingsway Hospitals, Nagpur, Maharashtra, India.

Brown tumor is unifocal or multifocal bone disease which represents terminal stage of hyperparathyroidism (HPT)-dependent bone pathology. It is recognized as a component of metabolic bone disease called osteitis fibrosa cystica generalisata or Von Recklinghausen disease of bone. HPT was first described by Von Recklinghausen in 1891. Read More

J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S51-S54. Epub 2020 Feb 28.

Denta Care Super Speciality Dental Clinic, Gulbarga, Karnataka, India.

Anterior maxillary swellings are commonly encountered in the adolescents and adults and they represent lesions ranging from cysts to tumors which can be both benign as well as malignant. However the anterior maxillary swellings are a rare phenomenon in the infants and toddlers and they generally are indicative of an aggressive lesion. We hereby present a case of a rapidly growing infantile swelling which was histopathologically diagnosed as Peripheral Giant Cell Granuloma. Read More

J Int Soc Prev Community Dent 2020 Jan-Feb;10(1):36-45. Epub 2020 Jan 24.

Oral and Maxillofacial Surgery, Boston University, Boston, MA, USA.

Aims And Objectives: This study aimed to review the success or remission of intralesional medicaments in the management of intraosseous lesions in the oral cavity.

Materials And Methods: A comprehensive search was performed in two databases (PubMed and Scopus). Research articles, case reports, case series, and clinical trials were included. Read More

JAAD Case Rep 2020 Mar 19;6(3):184-186. Epub 2020 Feb 19.

Naval Hospital Guam, Agana Heights, Guam.

Trends Immunol 2020 Apr 28;41(4):286-299. Epub 2020 Feb 28.

Inflammation and Immunity of the Respiratory Epithelium - EA7426 (PI3) - South Medical University Hospital - Lyon 1 Claude Bernard University, Pierre-Bénite, France; Department of Molecular and Medical Genetics, Hospices Civils de Lyon, University Hospital, Bron, France. Electronic address:

Sarcoidosis is an enigmatic multisystem disease characterized by the development and accumulation of granulomas: a compact collection of macrophages that have differentiated into epithelioid cells and which are associated with T helper (Th)1 and Th17 cells. Although no single causative factor has been shown to underlie sarcoidosis in humans, its etiology has been related to microbial, environmental, and genetic factors. We examine how these factors play a role in sarcoidosis pathogenesis. Read More

Insights Imaging 2020 Feb 13;11(1):23. Epub 2020 Feb 13.

Department of Neuroradiology, Hospital Universitari de Bellvitge, C. Feixa Llarga SN, 08907, L'Hospitalet de Llobregat, Spain.

The skull vault, formed by the flat bones of the skull, has a limited spectrum of disease that lies between the fields of neuro- and musculoskeletal radiology. Its unique abnormalities, as well as other ubiquitous ones, present particular features in this location. Moreover, some benign entities in this region may mimic malignancy if analyzed using classical bone-tumor criteria, and proper patient management requires being familiar with these presentations. Read More

Autops Case Rep 2020 Jan-Mar;10(1):e2019127. Epub 2019 Dec 13.

Sri Balaji Vidyapeeth University, Indira Gandhi Institute of Dental Sciences, Department of Oral Pathology and oral Microbiology. Puducherry, Puducherry, India.

Peripheral Ameloblastoma (PA) is a benign odontogenic tumor, arising from the cell rest of Serres, reduced enamel epithelium and basal cells of the surface epithelium. Peripheral ameloblastoma is a rare odontogenic neoplasm occurring commonly in the mandibular gingiva. PA clinically resembles other peripherally occurring lesions like pyogenic granuloma, peripheral ossifying fibroma, peripheral giant cell granuloma, and squamous papilloma. Read More

West Afr J Med 2020 Jan-Mar;37(1):26-31

Department of Oral & Maxillofacial Surgery and Oral Pathology, Obafemi Awolowo University/Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria.

Background And Objectives: Giant cell lesions (GCLs) are rare lesions which prominently feature multinucleated giant cells in their histology. They include central giant cell granuloma (CGCG), giant cell tumour of bone (GCT), peripheral giant cell granuloma (PGCG), Cherubism (CHB), e.t. Read More

Urologiia 2019 12(6):113-114

Hitit Universtiy, Corum Training and Research Hospital, Department of Nephrology, Corum, Turkey.

Suture granuloma is very rare complication of surgical procedures developing from the non-absorbable sutures. The development of suture granuloma is a chronic process and includes multinucleated giant cell formation. It has two step process including the initial reaction of tissue inflicted the passage of the needle and specific inflammatory reaction of the suture material. Read More

Oral Dis 2020 Jan 24. Epub 2020 Jan 24.

Department of Dentistry, State University of Maringá (UEM), Maringá, Brazil.

Hyaline ring granuloma (HRG) is a rare and atypical foreign-body granulomatous chronic inflammatory condition. Our aim was to make a critical review of the literature cases and also to illustrate histochemical and immunohistochemical findings of a new case. A modified PICO strategy was used. Read More

J Korean Assoc Oral Maxillofac Surg 2019 Dec 26;45(6):316-323. Epub 2019 Dec 26.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kocaeli University, Kocaeli, Turkey.

Objectives: This study aimed to determine the prevalence of odontogenic cysts, tumors, and other lesions among reports in the archives of the Department of Oral and Maxillofacial Surgery at the Faculty of Dentistry affiliated with Kocaeli University collected over a four-year period.

Materials And Methods: In this retrospective study, patient records from the archive of the Department of Oral and Maxillofacial Surgery from 2014 to 2018 were reviewed. Patient demographic information (age and sex) and lesion location were recorded and analyzed. Read More

Head Neck Pathol 2020 Mar 16;14(1):97-108. Epub 2020 Jan 16.

Department of Anatomical Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung, 833, Taiwan.

Giant cell-rich lesions represent a heterogeneous group of tumors and non-neoplastic lesions, usually arising in bone, which harbor varying number of reactive osteoclastic-type multinucleate giant cells as a common feature. Among these entities, some are confined to the head and neck region (e.g. Read More

World Neurosurg 2020 Apr 10;136:66-69. Epub 2020 Jan 10.

Department of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, China. Electronic address:

Background: Giant cell reparative granuloma (GCRG) is a rare benign tumor. The jawbone is the most common site of occurrence, followed by sphenoid bone, craniofacial bone, hand and foot bones. The etiology of GCRG is unknown but may be related to an intraosseous hemorrhage following trauma. Read More

Rom J Morphol Embryol 2019 ;60(3):811-822

Department of Implantology, Removable Prosthesis, Dental Prosthesis Technology, Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Iaşi, Romania;

Background: Gingival overgrowth refers to an increase in the size of the gingival tissue. The etiology varies, and is often a multi-factor issue; what may contribute to gingival enlargement are aspects, such as disease, local and systemic conditions and idiopathic factors. The aim of the present study is to analyze and to correlate the clinical, epidemiological, imaging and histopathological (HP) features of gingival overgrowth in northeastern Romanian population. Read More

Heliyon 2020 Jan 28;6(1):e03085. Epub 2019 Dec 28.

Maxillo-Facial Surgery Unit, Asst Spedali Civili, Brescia, Italy.

Introduction: Central giant cell granuloma is a benign intraosseous lesion; tumours in the condylar region are rarely reported.

Case Presentation: We present the case of a 60-year-old woman with preauricular swelling, limitation of joint motion and pain on only the right side.

Discussion: The patient was evaluated based on her preoperative clinical manifestations, by orthopantomography and computed tomography (CT). Read More

Am J Clin Pathol 2020 Apr;153(5):630-638

Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora.

Objectives: Histologic findings after endoscopic resection using submucosal lifting agents Eleview and ORISE gel are described.

Methods: Four cases were identified based on the histologic presence of ORISE gel. Cases were selected to illustrate the histologic appearance of the lifting agent immediately after injection (day 0) and after an interval of approximately 2 months. Read More

Head Neck Pathol 2019 Dec 23. Epub 2019 Dec 23.

Department of Oral & Maxillofacial Pathology, Nair Hospital Dental College, Dr. A.L. Nair Road, Mumbai Central, Mumbai, 400008, India.

Giant cell tumour (GCT) is locally aggressive benign neoplasm of long bones whereas giant cell granulomas; central giant cell granuloma (CGCG) and peripheral giant cell granuloma (PGCG); are tumour-like conditions of the oral cavity. This study aimed to evaluate and compare the immunohistochemical expression of p63 in GCT, CGCG, PGCG and determine whether p63 can be used as a diagnostic, prognostic and differential biomarker between these entities. Histopathologically diagnosed 10 cases of GCT, 20 cases of CGCG and 20 cases of PGCG were subjected to p63 immunohistochemical staining. Read More

Ann R Coll Surg Engl 2020 Mar 18;102(3):e75-e76. Epub 2019 Dec 18.

Department of Radiology, Medical Faculty, Ataturk University, Erzurum, Turkey.

Giant cell reparative granuloma is an unusual benign process arising especially in the maxillofacial bones. It occurs in the second and third decades, predominantly in children and young adults, and is classified as peripheral (located in gingival tissues) and central (located in bone). We presented an unusual case with a lytic and aggressive radiological appearance. Read More

BMJ Case Rep 2019 Dec 16;12(12). Epub 2019 Dec 16.

Department of Dermatology and Venereology, Hospital de Braga, Braga, Portugal.

Elastolytic giant cell granuloma (EGCG), also known as actinic granuloma, is an uncommon granulomatous dermatosis usually characterised by asymptomatic annular plaques on sun-exposed skin. Its aetiology is not fully elucidated, but actinic damage has been considered the main causal factor. Atypical variants with lesions in a non-photodistributed pattern are rare and often related to a systemic disorder, suggesting a more complex pathogenesis and demanding for a screening work-up. Read More

BMC Oral Health 2019 12 16;19(1):283. Epub 2019 Dec 16.

Graduate Program in Dentistry, Health Institute of Nova Friburgo, Universidade Federal Fluminense, Nova Friburgo, Rio de Janeiro, Brazil.

Background: Peripheral giant cell granuloma (PGCG) is an uncommon pathology that affects gingival or alveolar mucosa. Although PGCG can be associated with dental implants, little is known about this lesion and implant osseointegration as well as its etiopathogenesis and the treatments available. This study sought to report a rare case of PGCG associated with dental implant, emphasizing its clinical and histopathological aspects. Read More

Virchows Arch 2020 Jan 14;476(1):159-174. Epub 2019 Dec 14.

Bone Tumour Reference Centre, Institute of Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.

According to the WHO, mesenchymal tumours of the maxillofacial bones are subdivided in benign and malignant maxillofacial bone and cartilage tumours, fibro-osseous and osteochondromatous lesions as well as giant cell lesions and bone cysts. The histology always needs to be evaluated considering also the clinical and radiological context which remains an important cornerstone in the classification of these lesions. Nevertheless, the diagnosis of maxillofacial bone tumours is often challenging for radiologists as well as pathologists, while an accurate diagnosis is essential for adequate clinical decision-making. Read More

Front Pediatr 2019 15;7:480. Epub 2019 Nov 15.

Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangzhou, China.

Giant cell tumor of tendon sheath (GCTTS) is characterized by diffuse proliferation of synovial-like cells and multinucleated giant cells along tendon sheaths. This benign tumor typically presents in the third to fourth decade of life and is exceeding rare in children. Here we describe a case of a 10-years-old girl with a history of soft tissue swelling involving the third digit of left hand, bilateral wrists and ankles. Read More

Clin Case Rep 2019 Nov 8;7(11):2287-2288. Epub 2019 Oct 8.

Section of Haematology, Department of Pathology & Laboratory Medicine/Oncology Aga Khan University Karachi Karachi Pakistan.

What is the significance of bone marrow examination in presence of peripheral cytopenias? It is still regarded as a mandatory investigation to diagnose hematological disorders. In this case, bone marrow trephine was initially done as a diagnosis of exclusion for ITP, whereas it revealed multiple granulomas suggesting mycobacterium tuberculosis infection. Read More

Front Dent 2019 Mar-Apr;16(2):153-157. Epub 2019 Apr 30.

Department of Prosthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Dental implants are highly recommended to improve the retention, stability, and support of prostheses in edentulous patients with large surgical defects. Depending on the size of the defect, a bone graft procedure might be necessary. However, due to limitations of bone grafts, some complications might negatively affect the prosthetic rehabilitation of the patient. Read More

Oral Dis 2020 Mar 19;26(2):334-340. Epub 2019 Dec 19.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

Objectives: To investigate the molecular pathogenesis of implant-associated peripheral giant cell granuloma (IA-PGCG).

Methods: A convenience sample of 15 IA-PGCG cases was selected. Hotspot mutations of KRAS, FGFR1, and TRPV4 genes, previously reported in conventional giant cell lesions of the jaws, were investigated by Sanger sequencing. Read More

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2019 Aug;27(Special Issue):608-622

Russian Children's Clinical Hospital of Pirogov Russian National Research Medical University, 119571, Moscow, Russia.

The family form of giant cell reparative granuloma or cherubism is a rare benign lesion of the jaws which causes face deformation reminiscent of the cherubs portrayed in Renaissance art. Radical surgery, especially in children before puberty, is impossible or irrational, because it leads to disablement. For four years, a child with cherubism was undergoing an outpatient supervision in the Department of Maxillofacial Surgery in Russian Children Clinical Hospital. Read More

Br J Oral Maxillofac Surg 2020 01 15;58(1):75-78. Epub 2019 Nov 15.

Department of Oral and Maxillofacial Surgery, CHUV, Lausanne, Switzerland.

Treatment of bony tumours of the oral and maxillofacial area usually involve resection. However, access to certain areas may be difficult because of the size or site of the tumour. A poor view of the lesion during operation is another limiting factor, which can lead to incomplete resection in difficult cases. Read More

Skeletal Radiol 2020 02 12;49(2):337. Epub 2019 Nov 12.

Douglass Hanly Moir Pathology, 14 Giffnock Avenue Macquarie Park, Sydney, NSW, 2113, Australia.