3,281 results match your criteria Peripheral Giant Cell Granuloma


Annular elastolytic giant cell granuloma: mysterious enlarging scarring lesions.

Cutis 2019 Jan;103(1):E5-E7

Department of Dermatology, Tripler Army Medical Center, Honolulu, Hawaii, USA.

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January 2019

Lumps and Bumps of the Gingiva: A Pathological Miscellany.

Head Neck Pathol 2019 Jan 29. Epub 2019 Jan 29.

Academic Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield, S10 2TA, UK.

Lesions of the gingivae are amongst the commonest lesions seen in patients and the vast majority are reactive hyperplasias, related to a number of chronic irritant stimuli. However, there are a number of entities that have a predilection for the gingivae, which are much less common in other parts of the oral cavity. The purpose of this paper is to discuss the clinical and histological differential diagnoses when presented with a lump on the gingivae, including the approach to diagnosis and diagnostic pitfalls. Read More

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http://dx.doi.org/10.1007/s12105-019-01000-wDOI Listing
January 2019
1 Read

Denosumab Treatment for Aggressive Multiple Recurrent Familial Central Giant-cell Granulomas.

Ann Maxillofac Surg 2018 Jul-Dec;8(2):265-269

Department of Oral and Maxillofacial Surgery, University of Oulu and Oulu University Hospital, Oulu, Finland.

Background: Aggressive familial giant-cell granulomas of the jaws can be severely deforming. Surgical and nonsurgical treatments may be associated with multiple recurrences. Denosumab, a new generation antiresorptive drug, is an osteoclast inhibitor, which may be particularly useful to manage such potentially disfiguring lesions. Read More

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http://www.amsjournal.com/text.asp?2018/8/2/265/248587
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http://dx.doi.org/10.4103/ams.ams_192_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327812PMC
January 2019
1 Read

Evaluation of Cyclin D1 Expression in Aggressive and Nonaggressive Central Giant Cell Granuloma of the Jaws.

J Dent (Shiraz) 2018 Dec;19(4):253-258

Dept. of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Statement Of The Problem: Central giant cell granuloma of the jaws is comprised of two types namely aggressive and nonaggressive. Controversy exists regarding the histogenesis of this lesion. Up to now, there are no reliable histologic or molecular methods to differentiate aggressive from nonaggressive central giant cell granuloma of the jaw. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338689PMC
December 2018

Peripheral giant cell granuloma associated with dental implants: a systematic review.

J Stomatol Oral Maxillofac Surg 2019 Jan 21. Epub 2019 Jan 21.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas-Gerais, Belo Horizonte, Brazil. Electronic address:

The purpose of the present review was to integrate the available published data on peripheral giant cell granuloma (PGCG) associated with dental implants into a comprehensive analysis of its clinical/radiologic features. An electronic search was undertaken in February/2018 in three databases, looking for publications reporting cases of PGCGs associated with dental implants. Nineteen publications were included, reporting 37 implant-associated PGCG. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.01.010DOI Listing
January 2019

An insight into the cannibalistic behavior of giant cell granulomas of the jaws.

J Oral Maxillofac Pathol 2018 Sep-Dec;22(3):449

Department of Oral Pathology and Microbiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.

Background: Cellular cannibalism is defined as a large cell engulfing a smaller one within its cytoplasm. It is predominantly a feature of aggressive malignancies but has recently been demonstrated in giant cell (GC) lesions such as GC tumor of tendon sheath, central GC granuloma (CGCG) and peripheral GC granuloma (PGCG).

Aim: The aim of the study is to assess the cannibalistic GCs in CGCG and PGCG and correlate with aggressiveness of the lesion. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_67_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306579PMC
January 2019

Giant cell reparative granuloma of the scapula: report of a case and literature review.

Skeletal Radiol 2019 Jan 4. Epub 2019 Jan 4.

Department of Orthopedics and Orthopedic Oncology, University of Padova, Via Giustiniani 3, Padova, Italy.

Giant cell reparative granulomas (GCRGs) are non-neoplastic inflammatory lesions, usually observed in the maxilla, mandible or small bones of the hands and feet. These lesions present a wide range of morphology and the misinterpretation with other giant cell lesions can often occur. We report the case of a 47-year-old woman with GCRG in the left scapula, presenting some uncommon features: the location (scapula) and age at presentation, the lack of underlying bone disease such as Paget's disease or fibrous dysplasia, the large aggressive expansile aspect of the lesion. Read More

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http://dx.doi.org/10.1007/s00256-018-3132-0DOI Listing
January 2019
3 Reads

Giant Cell Arteritis with Generalized Granuloma Annulare: A Case Report.

Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan.

We report the case of an 80-year-old man with generalized granuloma annulare (GGA) who subsequently developed giant cell arteritis (GCA). Steroid treatment was effective for both diseases in this case. Although cases of concomitant GGA and GCA have rarely been reported, previous studies suggest that common histological characteristics underlie the two diseases. Read More

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http://dx.doi.org/10.2169/internalmedicine.1978-18DOI Listing
December 2018
2 Reads

Computer-assisted analysis of immunohistological parameters in oral giant cell granulomas.

Oral Dis 2018 Dec 18. Epub 2018 Dec 18.

Section of Oral and Maxillofacial Pathology, Division of Diagnostic and Surgical Sciences, School of Dentistry, University of California at Los Angeles, Los Angeles, California.

Objective: The aim of this study was to examine the relationship between active osteoclasts, as defined by positive nuclear NFATc1 signals, and the clinical behaviors of oral giant cell granulomas.

Materials And Methods: NFATc1 immunohistochemical and TRAP-Cbfa1 double immunofluorescence stainings were performed on 9 cases of peripheral giant cell granulomas (PGCGs), 9 cases of central giant cell granulomas (CGCGs) with a recurrent history, and 10 cases of CGCGs without a recurrent history. The results were photographed and quantified by ImageJ. Read More

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http://dx.doi.org/10.1111/odi.13022DOI Listing
December 2018

Peripheral giant-cell granuloma in peri-implant tissues

Swiss Dent J 2018 Dec;128(12):980-981

Kempf und Pfaltz, Histologische Diagnostik, Zürich

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December 2018

Diagnostic and therapeutic approaches in oral cavity granulomas based on new data concerning their origin and pathogenesis.

Rom J Morphol Embryol 2018 ;59(3):679-690

Discipline of Histology, Department of Morphological Sciences, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania;

Giant cell granulomas in the oral cavity are reactive hyperplastic lesions that arise either peripherally in the mucoperiosteum or centrally in the bone. The peripheral giant cell granuloma (PGCG) is a benign lesion induced by local chronic irritation. It may develop at any age, and tends to be more frequent in females. Read More

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December 2018
3 Reads

Pleural anthracosis presenting with massive effusion: a rare entity.

Respirol Case Rep 2019 Feb 28;7(2):e00390. Epub 2018 Nov 28.

Respiratory Department Universiti Kebangsaan Malaysia Medical Centre Kuala Lumpur Malaysia.

Pleural anthracosis is rare and, in most cases, is diagnosed incidentally or at autopsy. We report a 67-year-old man with pleural anthracosis. He was initially referred for possible tuberculous pleural effusion and had recurrent admissions for symptomatic pleural effusion, which increased with each subsequent episode. Read More

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http://dx.doi.org/10.1002/rcr2.390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261927PMC
February 2019
3 Reads

Surgical management and long-term outcomes of intracranial giant cell tumors: a single-institution experience with a systematic review.

J Neurosurg 2018 Oct 1:1-11. Epub 2018 Oct 1.

1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing; and.

OBJECTIVEIntracranial giant cell tumors (GCTs) are extremely rare neoplasms with dismal survival and recurrence rates. The authors aimed to confirm independent adverse factors for progression-free survival (PFS) and to propose an optimal treatment algorithm.METHODSThe authors reviewed the clinical data of 43 cases of intracranial GCTs in their series. Read More

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http://dx.doi.org/10.3171/2018.4.JNS1849DOI Listing
October 2018
4 Reads
3.737 Impact Factor

Granulomatous Reaction on a Double-Level Cervical Total Disc Arthroplasty.

World Neurosurg 2019 Feb 17;122:360-363. Epub 2018 Nov 17.

Department of Neurosurgery, Saint-Luc Hospital, Université Catholique de Louvain, Brussels, Belgium. Electronic address:

Background: Cervical total disc arthroplasty (TDA), or cervical artificial disc replacement, is an alternative technique to anterior cervical discectomy and fusion for treatment of symptomatic degenerative cervical spine disease. The main goal of TDA is to maintain cervical motion and lower the risk of deterioration of adjacent levels. Granuloma formation on a cervical TDA is exceptional. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183261
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http://dx.doi.org/10.1016/j.wneu.2018.11.070DOI Listing
February 2019
13 Reads

Sarcoidosis.

J Fr Ophtalmol 2018 Dec 16;41(10):e451-e467. Epub 2018 Nov 16.

Department of Ophthalmology, hôpital Cochin, Assistance publique-Hôpitaux de Paris, université Paris Descartes, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.

Sarcoidosis is a systemic granulomatosis characterized by the formation of epithelioid and giant cell granulomas without caseous necrosis. To make the diagnosis, it is necessary to prove systemic granulomatosis involving at least two organs; but in practice, a combination of clinical, paraclinical and histologic findings is used. It affects predominantly women with a bimodal age distribution: 25-29 years and 65-69 years. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.10.002DOI Listing
December 2018
3 Reads

Benign Oral Mucosal Lesions: Clinical and Pathological Findings Part I- Benign Oral Mucosal lesions.

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Boston University School of Medicine, Boston, MA. Electronic address:

A diverse spectrum of benign oral mucosal lesions exists, presenting as either isolated oral findings or in association with dermatological conditions. Oral lesions can closely resemble one another; therefore, it is important for clinicians to be able to recognize their distinctive features and recognize benign versus malignant disease and when a biopsy is warranted. In this continuing medical education series, we review oral anatomy and the clinical attributes of several benign lesions of the oral cavity along with the appropriate management and therapeutic modalities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183288
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http://dx.doi.org/10.1016/j.jaad.2018.09.061DOI Listing
November 2018
11 Reads

Peripheral giant cell granuloma manifestation in pregnancy.

Indian J Dent Res 2018 Sep-Oct;29(5):678-682

Department of Periodontology, Government Dental College and Hospital, Mumbai, Maharashtra, India.

The peripheral giant cell granuloma (PGCG) is a benign oral lesion occurring on the gingiva and alveolar ridge. It is the most common oral lesion and occurs at an average age of 30 years. The upsurge in the levels of estrogen and progesterone in pregnancy leads to a plethora of changes in various parts of human body, including the oral cavity. Read More

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http://dx.doi.org/10.4103/ijdr.IJDR_110_17DOI Listing
November 2018
1 Read

Immunohistochemical expression of RANKL in oral giant cell lesions is predictive of aggressiveness.

Braz Oral Res 2018 Oct 29;32:e115. Epub 2018 Oct 29.

Universidade Federal de Santa Catarina - UFSC, Department of Pathology, Florianópolis, Santa Catarina, Brazil.

The aim of this study was to evaluate the immunohistochemical expression of receptor activator of nuclear factor kappa-B ligand (RANKL) and of osteoprotegerin (OPG), important proteins correlated with osteoclastogenesis, in central giant cell lesions (CGCL) and peripheral giant cell lesions (PGCL) and to compare their expression with the histological and clinical parameters for quantification of multinucleated giant cells (MGC) and their nuclei, lesion size, and recurrences. Twenty cases of each lesion type were selected to quantify the number of MGCs and nuclei/mm2 of connective tissue. The immunoreactivity of RANKL and OPG was expressed as a percentage of the marked area in the stroma. Read More

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http://dx.doi.org/10.1590/1807-3107bor-2018.vol32.0115DOI Listing
October 2018
1 Read

Treatment of the benign lytic lesions of the proximal femur with synthetic bone graft.

J Orthop Surg Res 2018 Oct 29;13(1):270. Epub 2018 Oct 29.

Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

Background: Benign bone tumors and tumor-like conditions are commonly located in the proximal femur. The main indications for surgical treatment are lesions with impending or actual pathological fractures, or with aggressive or recurrent lesions. However, patients complaining of persistent pain, limping, or abnormal gait patterns are also considered for surgical treatment. Read More

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https://josr-online.biomedcentral.com/articles/10.1186/s1301
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http://dx.doi.org/10.1186/s13018-018-0982-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206894PMC
October 2018
9 Reads

[Epidemio-clinical features of genital tuberculosis among Tunisian women: a series of 47 cases].

Pan Afr Med J 2018 29;30:71. Epub 2018 May 29.

Service des Maladies Infectieuses, Hôpital la Rabta, Tunis, Tunisie.

This study aimed to identify the epidemio-clinic, diagnostic, therapeutic and evolutionary features of genital tuberculosis (GT) among Tunisian women. We conducted a retrospective, descriptive study in the Department of Infectious Diseases at the La Rabta Hospital, Tunisia, over a period of 15 and a half years (January 2000 - June 2014). All patients hospitalized for genital TB were included in the study. Read More

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http://www.panafrican-med-journal.com/content/article/30/71/
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http://dx.doi.org/10.11604/pamj.2018.30.71.14479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191266PMC
October 2018
11 Reads

Hypermetabolic lesion in the prevascular mediastinum - always a thymoma/lymphoma?

Acta Chir Belg 2018 Oct 1:1-2. Epub 2018 Oct 1.

a AZ Sint-Jan Brugge-Oostende AV , Brugge , Belgium.

Cholesterol granuloma is a foreign-body giant cell reaction that can occur in response to the presence of cholesterol crystals. They are usually found in the middle ear, paranasal sinuses or mastoid process due to chronic inflammation. Presentation in the prevascular mediastinum is a rare finding. Read More

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http://dx.doi.org/10.1080/00015458.2018.1515336DOI Listing
October 2018
3 Reads

Coordinated pediatric reconstruction and rehabilitation of maxillary central giant cell granuloma: A case report.

J Am Dent Assoc 2018 Dec 20;149(12):1065-1072. Epub 2018 Sep 20.

Background And Overview: A 9-year-old girl underwent comprehensive resection and rehabilitation of a central giant cell granuloma that required phased interprofessional collaborative care to optimize treatment decisions and outcome.

Case Description: The interprofessional treatment team included an oral and maxillofacial surgeon, maxillofacial prosthodontist, dentist, orthodontist, and speech-language pathologist, and treatment spanned 9 years. Treatment included surgical resection of a central giant cell granuloma and obturation with a removable interim prosthesis. Read More

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http://dx.doi.org/10.1016/j.adaj.2018.07.020DOI Listing
December 2018
1 Read

Phosphoglyceride crystal deposition disease in the abdominal wall: a case report.

Surg Case Rep 2018 Sep 19;4(1):120. Epub 2018 Sep 19.

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto City, Kumamoto, 860-8556, Japan.

Background: Phosphoglyceride crystal deposition disease (PGDD) is characterized by phosphoglyceride crystal deposition that simulates neoplasia in soft tissue scars or bone. Reports of PGDDs are rare. Here, we present the case of a patient with PGDD in the abdominal wall. Read More

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http://dx.doi.org/10.1186/s40792-018-0516-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146114PMC
September 2018
1 Read

[Visceral parasitic migration of liver: a clinicopathologic analysis of seven cases].

Zhonghua Bing Li Xue Za Zhi 2018 Sep;47(9):710-713

Department of Pathology, the Affiliated Drum Tower Hospital of Medical School of Nanjing University, Nanjing 210008, China.

To investigate the clinical, radiological and pathological features of visceral parasitic migration of the liver. Seven cases of visceral parasitic migration of liver were identified at the Affiliated Drum Tower Hospital of Medical School of Nanjing University from January 2008 to July 2017. Clinical data, enhanced CT image and pathological features were analyzed, combining with literature review. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.09.012DOI Listing
September 2018
1 Read

Case Reports of a Giant Cell Reparative Granuloma and a Giant Cell Tumor on Temporal Bone.

Chin Med J (Engl) 2018 Sep;131(18):2254-2256

Department of Radiology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin 300350, China.

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http://dx.doi.org/10.4103/0366-6999.240820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144851PMC
September 2018
10 Reads

Tuberculous gummas: Epidemiological, clinical, bacteriological, immunological, and therapeutic features.

Int J Mycobacteriol 2018 Jul-Sep;7(3):203-211

Department of Dermatology, Mohammed V Military Hospital, Mohammed V University of Rabat, Rabat, Morocco.

Tuberculous gummas are an unusual form of tuberculosis (TB) accounting for 1%-2% of all cutaneous TB cases. The aim of this article was to describe the epidemiological, clinical, bacteriological, immunological, and therapeutic features of this form upon a case report and a literature review. Forty-eight case reports were identified through a PubMed and Google Scholar search using the following keywords: "tuberculous gumma" and "metastatic tuberculous abscesse. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_83_18DOI Listing
September 2018
1 Read

Expansile radiolucent lesion of the Temporomandibular Joint-A diagnostic enigma.

J Oral Biol Craniofac Res 2018 Sep-Dec;8(3):203-205. Epub 2017 Jul 1.

Department of Oral Pathology, Government Dental College and Hospital, St. George Hospital Campus, Near Chhatrapati Shivaji Terminus Area, Fort, Mumbai, Maharashtra 400001, India.

Radiolucent lesions of Temporomandibular Joint (TMJ) represent a diagnostic challenge and a treatment conundrum. Biopsy of the lesions is technically difficult owing to their complex anatomy. The Differential Diagnosis (DD) includes a wide array of lesions including Simple Bone Cyst, Ameloblastoma, Central Giant Cell Granuloma, Hemangioma, Osteoblastoma, Osteochondroma, Chondroblastoma, Chondrosarcoma, Neurofibroma and metastatic malignant lesions though none has a specific predilection for TMJ. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22124268173008
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http://dx.doi.org/10.1016/j.jobcr.2017.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107912PMC
July 2017
6 Reads

Bilateral Central Giant Cell Granuloma of the mandibular angle in three females from the same family.

Head Face Med 2018 Sep 4;14(1):14. Epub 2018 Sep 4.

Maxillo-Facial Surgery Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, Via Lorenzo Natali 1: Località Coppito, 67100, L'Aquila, AQ, Italy.

In literature there are few reports about multiple CGCG. But this is the first report of bilateral CGCG of the mandibular angles in three females from the same family.This report describes three cases of females from the same family - a mother and two young daughters - with bilateral CGCG in their jaw angles. Read More

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https://head-face-med.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13005-018-0171-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122611PMC
September 2018
4 Reads

Clinicopathological profile of central giant cell granulomas: An institutional experience and study of immunohistochemistry expression of p63 in central giant cell granuloma.

J Oral Maxillofac Pathol 2018 May-Aug;22(2):173-179

Department of Oral Pathology, PMNM Dental College and Hospital, Bagalkot, Karnataka, India.

Background: The central giant cell granuloma(CGCG) of bone constitutes about 10% of benign jawbone lesions. It affects females more often than males, mandible than maxilla. Biological behavior of CGCG ranges from a slow growing asymptomatic swelling to an aggressive process. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_260_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097366PMC
August 2018
14 Reads

Comparative Study of Correlation between Angiogenesis Markers (CD31) and Ki67 Marker with Behavior of Aggressive and Nonaggressive Central Giant Cell Granuloma with Immunohistochemistry Technique

Asian Pac J Cancer Prev 2018 Aug 24;19(8):2279-2283. Epub 2018 Aug 24.

Dental Material Research Center. Department of Oral and Maxillofacial, Dental School, Isfahan University of Medical Sciences, Isfahan, Iran. Email:

Background: The central giant cell granuloma (CGCG) is generally considered a non-neoplastic lesion. However, some cases show aggressive behavior like neoplasms. Based on clinical observations, a number of researchers have classified this lesion into aggressive and non- aggressive types. Read More

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http://dx.doi.org/10.22034/APJCP.2018.19.8.2279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171410PMC
August 2018
1 Read
1.500 Impact Factor

IL-13-regulated Macrophage Polarization during Granuloma Formation in an In Vitro Human Sarcoidosis Model.

Am J Respir Cell Mol Biol 2019 Jan;60(1):84-95

6 Texas Biomedical Research Institute, San Antonio, Texas.

The mechanisms underlying abnormal granuloma formation in patients with sarcoidosis are complex and remain poorly understood. A novel in vitro human granuloma model was used to determine the molecular mechanisms of granuloma genesis in patients with sarcoidosis in response to putative disease-causing mycobacterial antigens. Peripheral blood mononuclear cells (PBMCs) from patients with active sarcoidosis and from normal, disease-free control subjects were incubated for 7 days with purified protein derivative-coated polystyrene beads. Read More

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http://dx.doi.org/10.1165/rcmb.2018-0053OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348723PMC
January 2019
22 Reads

Radiographic Diagnosis of a Central Giant Cell Granuloma Using Advanced Imaging: Cone Beam Computed Tomography.

Cureus 2018 Jun 5;10(6):e2735. Epub 2018 Jun 5.

Department of Oral Medicine and Diagnostic Sciences, CWRU School of Dental Medicine, Cleveland, USA.

Central giant cell granuloma (CGCG) is a benign non-neoplastic, proliferative intraosseous lesion of the jaw with an unknown etiology often diagnosed during the first two decades of life. The true nature of this lesion is controversial and remains elusive. Here, we report a case of central giant cell granuloma, diagnosed using cone-beam computed tomography (CBCT). Read More

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http://dx.doi.org/10.7759/cureus.2735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075625PMC
June 2018
10 Reads

Dermoscopy in annular elastolytic giant cell granuloma.

J Dermatol 2019 Feb 3;46(2):e66-e67. Epub 2018 Aug 3.

Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.

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http://dx.doi.org/10.1111/1346-8138.14539DOI Listing
February 2019
6 Reads

Selected Giant Cell Rich Lesions of the Temporal Bone.

Head Neck Pathol 2018 Sep 1;12(3):367-377. Epub 2018 Aug 1.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55902, USA.

Giant cell rich lesions of the temporal bone encompass a wide spectrum of disease that includes infectious, reactive, and neoplastic processes. When dealing with any lesion that can potentially involve bone, it is important to understand both the clinical presentation and to correlate the histologic findings with the radiologic imaging. This review discusses the clinical, the pathologic features including the differential diagnosis, and the treatment of some of the more commonly encountered giant cell rich entities in this region. Read More

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http://dx.doi.org/10.1007/s12105-018-0906-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081287PMC
September 2018
3 Reads

Solid aneurysmal bone cyst of the humerus mimics metastasis or brown tumor.

Clin Imaging 2018 Nov - Dec;52:117-122. Epub 2018 Jul 24.

Department of Orthopedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States of America.

Solid aneurysmal bone cyst (ABC) is a rare subtype of ABC that most commonly involves the small bones of the hands or feet. We present a case of a solid ABC of the distal humerus in a 52-year-old man with a history of chronic kidney disease and renal cell carcinoma. On imaging with plain radiographs, CT, and MRI, this expansile lucent lesion with solid internal enhancement had an appearance that overlapped with metastasis or brown tumor of hyperparathyroidism. Read More

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http://dx.doi.org/10.1016/j.clinimag.2018.07.020DOI Listing
January 2019
4 Reads
0.600 Impact Factor

Interplay of DDP4 and IP-10 as a Potential Mechanism for Cell Recruitment to Tuberculosis Lesions.

Front Immunol 2018 5;9:1456. Epub 2018 Jul 5.

Center for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark.

Introduction: is one of the world's most successful pathogens equipped to establish itself within the human host as a subclinical infection without overt disease. Unable to eradicate the bacteria, the immune system contains the infection in a granuloma structure. Th1 cells that are essential for infection control are recruited to the site of infection directed by chemokines, predominantly CXCL10. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041415PMC
July 2018
5 Reads

A Case of Annular Elastolytic Giant Cell Granuloma Associated with Syphilis.

Case Rep Dermatol 2018 May-Aug;10(2):158-161. Epub 2018 Jun 5.

Department of Dermatopathology, Shanghai Skin Disease Hospital, Shanghai, China.

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease characterized by annular patches with slightly raised borders, hypopigmented and/or atrophic centers found mainly on sun-exposed skin. Histologically, it is characterized by phagocytosis of elastic fibers by multinucleated giant cells. The pathogenesis of the disease is unclear. Read More

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http://dx.doi.org/10.1159/000489910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047546PMC
June 2018
17 Reads

A Case of Painless Excision.

Int J Clin Pediatr Dent 2018 Mar-Apr;11(2):135-140. Epub 2018 Apr 1.

Professor, Department of Pediatric and Preventive Dentistry, D Y Patil School of Dentistry, Navi Mumbai, Maharashtra, India.

Soft tissue lesions of the oral cavity are seen in children at the dental office. This case report aims to showcase the ability of laser to treat recurrent soft tissue lesions in the oral cavity in a painless manner. This painless procedure provides relief to the child and parent who suffer from anxiety toward dental treatment. Read More

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http://dx.doi.org/10.5005/jp-journals-10005-1499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034050PMC

Annular polycyclic plaques on the chest and upper back.

JAAD Case Rep 2018 Jun 24;4(5):405-407. Epub 2018 Apr 24.

Division of Dermatology, Veterans Affairs Medical Center, Kansas City, Kansas.

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http://dx.doi.org/10.1016/j.jdcr.2017.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031479PMC
June 2018
17 Reads

Undifferentiated sarcoma presenting as a slowly enlarging facial mass.

Ear Nose Throat J 2018 Apr-May;97(4-5):134-136

Department of Surgery, Division of Otolaryngology, UNM School of Medicine, MSC 10 5610, 1 University of New Mexico, Albuquerque, NM 87131, USA.

Head and neck sarcomas are rare and consist of a variety of histologic subtypes. We present a case of undifferentiated/unclassified sarcoma (UUS) of the maxillary sinus, a tumor subtype historically known as malignant fibrous histiocytoma (MFH) or undifferentiated pleomorphic sarcoma (UPS). A 50-year-old female patient presented with worsening facial pain and dysphagia. Read More

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November 2018
20 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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http://doi.wiley.com/10.1002/JPER.17-0719
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http://dx.doi.org/10.1002/JPER.17-0719DOI Listing
June 2018
35 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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http://dx.doi.org/10.1111/jcpe.12940DOI Listing
June 2018
55 Reads

Cell Viability and Tissue Reaction of NeoMTA Plus: An In Vitro and In Vivo Study.

J Endod 2018 Jul 1;44(7):1140-1145. Epub 2018 Jun 1.

Department of Conservative Dentistry, Dental School, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address:

Introduction: The aim of this study was to evaluate the cell viability and tissue reaction of NeoMTA Plus (NMP; Avalon Biomed Inc, Houston, TX) compared with mineral trioxide aggregate (MTA; Angelus, Londrina, PR, Brazil) and Biodentine (BD; Septodont, Saint-Maur-de-Fossés, France).

Methods: Fibroblasts (3T3) were plated and exposed to 1% extract from the test material before and after setting. Cytotoxicity assessment was performed using the 3-(4,5-dimethyl-thiazoyl)-2,5-diphenyl-tetrazolium bromide and sulforhodamine B assays. Read More

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http://dx.doi.org/10.1016/j.joen.2018.03.007DOI Listing
July 2018
23 Reads

Central Giant Cell Granuloma with Aneurysmal Bone Cyst in a 28-Year Male Patient: A Rare Concurrence.

J Coll Physicians Surg Pak 2018 Jun;28(6):S128-S129

Department of Oral and Maxillofacial Pathology, NIMS Dental College, Jaipur, India.

Central Giant Cell Granuloma (CGCG) is a benign tumor of jaw. As compared to males, females are more commonly affected. Mandible is the common site of occurrence. Read More

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http://dx.doi.org/10.29271/jcpsp.2018.06.S128DOI Listing
June 2018
26 Reads
0.320 Impact Factor

Giant cell lesion of the jaw as a presenting feature of Noonan syndrome.

BMJ Case Rep 2018 May 30;2018. Epub 2018 May 30.

Augusta University Medical College of Georgia, Augusta, Georgia, USA.

This is a case of a 20-year-old woman who presented with a left jaw mass which was resected and found to be a giant cell granuloma of the mandible. Her history and physical examination were suggestive for Noonan syndrome which was confirmed with genetic testing and the finding of a gene mutation which has rarely been associated with giant cell lesions of the jaw. Given her particular genetic mutation and the presence of a giant cell lesion, we present a case of Noonan-like/multiple giant cell lesion syndrome. Read More

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http://dx.doi.org/10.1136/bcr-2017-224115DOI Listing
May 2018
2 Reads

Giant Cell Granuloma: Two Expressions in Pediatric Population.

Int J Clin Pediatr Dent 2018 Jan-Feb;11(1):46-49. Epub 2017 Feb 1.

Postgraduate Student, Department of Pedodontics and Preventive Dentistry Buddha Institute of Dental Sciences & Hospital, Patna, Bihar India.

A granuloma is a collection of epithelioid histiocytes that is often associated with multinucleated giant cells, and is considered widely to be a non-neoplastic lesion, although some lesions demonstrate aggressive behavior similar to that of a neoplasm. The diagnosis of giant cell granulomas (central and peripheral) is confirmed by histopathologic examination. Early detection and excision are important to minimize potential dentoalveolar complications. Read More

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http://dx.doi.org/10.5005/jp-journals-10005-1482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968162PMC
February 2017
2 Reads

Comparsion of staining characteristics of Toto bodies.

Biotech Histochem 2018 21;93(5):336-339. Epub 2018 May 21.

a Department of Oral and Maxillofacial Pathology , St. Joseph Dental College , Eluru 534004 , Andhra Pradesh , India.

Toto bodies are eosinophilic structures that resemble the cells of the superficial cell layer of the oral epithelium. Toto bodies commonly are associated with inflammatory gingival and other mucosal lesions including pyogenic granuloma, irritational fibroma, epulis fissuratum, peripheral giant cell granuloma and inflammatory hyperplastic gingivitis. We evaluated staining characteristics of Toto bodies to establish their origin and to identify their significance in lesions. Read More

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https://www.tandfonline.com/doi/full/10.1080/10520295.2018.1
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http://dx.doi.org/10.1080/10520295.2018.1441441DOI Listing
December 2018
25 Reads

Granuloma formation associated with patellar tendon necrosis in response to Ethibond confirmed by histopathological examination.

BMJ Case Rep 2018 May 12;2018. Epub 2018 May 12.

Orthopedic Surgery, Hospital Universitari i Politecnic La Fe, Valencia, Spain.

The aim of this study is to describe a case of delayed granuloma formation associated with tendon necrosis in response to Ethibond confirmed by histopathological examination and to review and discuss the related literature. A 40-year-old woman underwent a patellar tendon repair with Krakow-like #5 Ethibond sutures. Four years after the repair, she noticed progressive soreness with knee extension and swelling. Read More

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http://dx.doi.org/10.1136/bcr-2017-222854DOI Listing
May 2018
3 Reads

Reactive oral lesions associated with dental implants. A systematic review.

J Investig Clin Dent 2018 Nov 11;9(4):e12342. Epub 2018 May 11.

Department of Diagnostic Sciences and Oral Medicine, University of Tennessee Health Science Center, College of Dentistry, Memphis, TN, USA.

Reactive lesion formation around dental implants a complication that has been given much consideration. These lesions can lead to marginal bone loss, and consequently, implant failure. In the present systematic review, all reported reactive lesions associated with dental implants in the literature were assessed. Read More

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http://dx.doi.org/10.1111/jicd.12342DOI Listing
November 2018
2 Reads

Central giant cell lesion of the jaws: An updated analysis of 2270 cases reported in the literature.

J Oral Pathol Med 2018 Sep 29;47(8):731-739. Epub 2018 May 29.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Purpose: To review all available data published on central giant cell lesion (CGCL) of the jaws into a comprehensive analysis of its clinical/radiological features, with emphasis on the predictive factors associated with its recurrence.

Methods: An electronic search was undertaken in 5 databases (February/2018), looking for reporting cases of CGCLs.

Results: A total of 365 publications were included, comprising 2270 lesions. Read More

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http://dx.doi.org/10.1111/jop.12730DOI Listing
September 2018