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    Denosumab as a Treatment Alternative for Central Giant Cell Granuloma: A Long-Term Retrospective Cohort Study.
    J Oral Maxillofac Surg 2017 Sep 21. Epub 2017 Sep 21.
    Resident, Department of Craniomaxillofacial and Oral Surgery, University Hospital of Zurich, Zurich, Switzerland.
    Purpose: Giant cell granuloma (GCG) of the jaw is a rare disease with high morbidity. Various treatment options have been discussed in the past. Since 2010, a pharmaceutical therapy with denosumab seems to have been successful for giant cell tumors of the femur. Read More

    Certolizumab Pegol-Induced Folliculitis-Like Lichenoid Sarcoidosis in a Patient with Rheumatoid Arthritis.
    Case Rep Dermatol 2017 Sep-Dec;9(3):158-163. Epub 2017 Sep 11.
    Department of Dermatology, Asahikawa City Hospital, Asahikawa, Japan.
    Anti-tumor necrosis factor α (TNF-α) biologic agents are used for treating refractory sarcoidosis. However, sarcoidosis-like epithelioid cell granulomas may develop during anti-TNF-α treatment. A 63-year-old man suffering from rheumatoid arthritis was treated with oral methotrexate and methylprednisolone for 4 years. Read More

    Central giant cell lesion of the mandible in a 2-year old girl.
    Imaging Sci Dent 2017 Sep 21;47(3):209-213. Epub 2017 Sep 21.
    Department of Oral and Maxillofacial Radiology, The Nippon Dental University Niigata Hospital, Niigata, Japan.
    Central giant cell lesions are rare, benign, osteolytic, pseudocystic, solitary, localized lesions that are common in the skeletal structure, but less so in the maxillofacial region. Furthermore, to perform panoramic radiography and cone-beam computed tomography, it is necessary to prepare patients properly and to position their heads carefully. However, this can be difficult in pediatric patients, who may be anxious. Read More

    Melanotic Macule in Conjunction with a Giant Cell Fibroma.
    J Contemp Dent Pract 2017 Oct 1;18(10):981-985. Epub 2017 Oct 1.
    Department of Periodontology, Lake Erie College of Osteopathic Medicine, School of Dental Medicine, Bradenton, Florida, USA, Phone: +9414051506, e-mail:
    Introduction: The aim of this study is to describe a case of a melanotic macule found in conjunction with a giant cell fibroma (GCF). For oral pigmented lesions without an identifiable etiologic factor, critical factors in determining the differential diagnosis are clinical history, symmetry, and uniformity of the lesions. Potential differential diagnosis includes racial pigmentation, endocrine disturbance, Peutz-Jeghers syndrome, trauma, hemochromatosis, oral malignant melanoma, or idiopathic etiology and melanotic macules. Read More

    Early Progression of Xanthogranulomatous Pyelonephritis in Children Might Be Dependent on Vimentin Expression.
    Am J Case Rep 2017 Oct 5;18:1066-1072. Epub 2017 Oct 5.
    Department of Pediatric Cardiology, Nephrology and Hypertensiology, Poznań University of Medical Sciences, Poznań, Poland.
    BACKGROUND Xanthogranulomatous pyelonephritis (XP) is an extremely rare, severe, atypical form of chronic renal parenchymal inflammation accompanied by hydronephrosis and/or urolithiasis. The pathomechanism of XP is not yet fully understood. Microscopically, XP is indicated by the presence of multinucleated giant cells and lipid-laden macrophages, as well as inflammatory infiltration and intensive renal fibrosis. Read More

    Langerhans Cell Histiocytosis Involving Both Jaws in an Adult.
    J Coll Physicians Surg Pak 2017 Sep;27(9):S89-S91
    Department of Pathology, Dow International Medical College, Dow University of Health Sciences, Ojha Campus, Karachi.
    Langerhans cell histiocytosis (LCH) is the latest terminology for a disorder of reticulo-endothelial system, previously known as histiocytosis X, and marked by aberrant proliferation of bone marrow derived Langerhans cells with variable inflammatory infiltrate including neutrophils, lymphocytes, plasma cells, eosinophils, and multinucleated giant cells. Although rare, the disorder frequently inflicts children with peak incidence recorded in 2-4 years age group. LCH is rare in adults. Read More

    Central Nervous System Inflammatory Myofibroblastic Tumor Masquerading as Chronic Suppurative Otitis Media.
    J Pediatr Neurosci 2017 Apr-Jun;12(2):188-191
    Department of Pathology, Immunohistochemistry, SRL Ranbaxy, Gurgaon, Haryana, India.
    Inflammatory myofibroblastic tumor (IMT) is a rare tumor in the central nervous system (CNS), mostly being extracranial. Approximately 100 sporadic cases have been reported in the literature. The rarity of the tumor, its various histopathological characteristics, and its variable aggressive course render it difficult to diagnose and treat. Read More

    Controversies in Oral and Maxillofacial Pathology.
    Oral Maxillofac Surg Clin North Am 2017 Nov;29(4):475-486
    Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Warren 1201, 55 Fruit Street, Boston, MA 02114, USA. Electronic address:
    Several benign pathologic entities that are commonly encountered by the oral and maxillofacial surgeon remain controversial. From etiology to treatment, no consensus exists in the literature regarding the best treatment of benign lesions, such as the keratocystic odontogenic tumor, giant cell lesion, or ameloblastoma. Given the need for often-morbid treatment to prevent recurrence of these lesions, multiple less-invasive treatments exist in the literature for each entity with little agreement. Read More

    Xanthoma-like Skin Changes in an Elderly Woman with a Normal Lipid Profile.
    Acta Dermatovenerol Croat 2017 Jul;25(2):167-169
    Professor Joanna Maj, MD, PhD, Department and Clinic of Dermatology, Venereology and Allergology, Wroclaw Medical University, Chałubińskiego 1, PL-50-368 Wrocław, Poland;
    Dear Editor, An 83-year-old woman developed yellow-brownish infiltrates, nodules, and tumors mimicking xanthomas, mostly involving the periorbital and chest area within three months (Figure 1). She had no abnormalities in serum cholesterol or triglycerides levels. A detailed laboratory analysis revealed the presence of mild monoclonal gammopathy with a presence of immunoglobulin G (IgG) kappa light chains; however, according to hematologist consultation, it did not require medical intervention. Read More

    Histologic Review of Sarcoidosis in a Neck Lymph Node.
    Head Neck Pathol 2017 Aug 29. Epub 2017 Aug 29.
    Department of Anatomic Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134-5000, USA.
    Sarcoidosis is a multisystem granulomatous disease of unknown etiology. It may occur at any age, but is most commonly seen in young to middle age adults. Sarcoidosis remains more common in women regardless of geographic or racial boundaries. Read More

    Are CD68 and Factor VIII-RA Expression Different in Central and Peripheral Giant Cell Granuloma of Jaw: An Immunohistochemical Comparative Study.
    Turk Patoloji Derg 2017 ;1(1):1-8
    Department of Oral Pathology, Shahid Beheshti University of Medical Sciences, School of Dentistry, TEHRAN, IRAN.
    Objective: Central giant cell granuloma and peripheral giant cell granuloma of the jaw and oral cavity are identical in histopathologic features, although they are different in pathogenesis and clinical behavior. The aim of present study was to compare CD 68 and factor VIII related antigen (VIII-RA ) immunoreactivity in central giant cell granuloma and peripheral giant cell granuloma to determine the biologic nature and clinical behavior of these lesions which may lead to a better or new treatment modality.

    Material And Method: CD68 and factor VIII-RA expression were examined immunohistochemically in 22 cases of central giant cell granuloma (10 aggressive and 12 non- aggressive ) and 19 cases of peripheral giant cell granuloma. Read More

    Bone-Related Lesions of the Jaws.
    Surg Pathol Clin 2017 Sep 2;10(3):693-704. Epub 2017 Jun 2.
    Bone Tumour Reference Centre at the Institute of Pathology, University Hospital Basel, University of Basel, Schoenbeinstrasse 40, Basel 4031, Switzerland. Electronic address:
    The jaws combine several unique properties that mainly result from their distinct embryonic development and their role in providing anchorage for the teeth and their supporting structures. As a consequence, several bone-related lesions almost exclusively develop in the jaws (eg, osseous dysplasias, ossifying fibromas), have distinct clinical features (eg, osteosarcoma), or hardly ever occur at this location (eg, osteochondroma, enchondroma). The specific characteristics of these tumors and tumorlike lesions are outlined in this article. Read More

    Idiopathic giant cell granuloma in the saddle area recurring soon after subtotal resection: a case report.
    Br J Neurosurg 2017 Aug 9:1-4. Epub 2017 Aug 9.
    a Department of Neurosurgery, Huadong Hospital, Fudan University , Shanghai , China.
    Giant cell granuloma is non-neoplastic proliferation of multinucleated giant cells and rarely occurs in the intracranial space. Here we report a 40-year-old man presented with left ptosis and impaired vision. Magnetic resonance imaging revealed a mass extending from the intrasellar area to the third ventricular floor, left cavernous sinus, retrochiasmatic area, and the left interpeduncular cistern. Read More

    [Eosinophilic granuloma of the parietal bone of an adult patient with BRAF mutation].
    Arkh Patol 2017 ;79(4):33-39
    Academician B.V. Petrovsky Russian Research Center of Surgery, Moscow, Russia.
    The paper describes a case of eosinophilic granuloma of the parietal bone in a 32-year-old man. Histological examination revealed a large number of bean-shaped Langerhans cell histiocytes with lobed nuclei and nuclear grooves. The histiocytes alternated with the foci of obvious eosinophilic infiltration and with eosinophilic microabscesses. Read More

    Hybrid Central Odontogenic Fibroma with Giant Cell Granuloma like Lesion: A Report of Three Additional Cases and Review of the Literature.
    Head Neck Pathol 2017 Aug 7. Epub 2017 Aug 7.
    Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, 1395 Center Drive, Gainesville, FL, 32610, USA.
    Central odontogenic fibroma (COF) is an uncommon intraosseous neoplasm of the gnathic bones which is composed of fibrous connective tissue, with or without calcifications, and variable amounts of inactive odontogenic epithelium. It makes up less than 5% of odontogenic tumors and is more commonly seen in females. Central giant cell granuloma (CGCG) is a locally destructive but benign lesion of the jaws containing osteoclast-like multinucleated giant cells in a fibrovascular stroma. Read More

    A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation.
    Mediators Inflamm 2017 12;2017:2982879. Epub 2017 Jul 12.
    INSERM U1026, Université de Bordeaux, 33000 Bordeaux, France.
    Granulomatous inflammation is a distinctive form of chronic inflammation in which predominant cells include macrophages, epithelioid cells, and multinucleated giant cells. Mechanisms regulating granulomatous inflammation remain ill-understood. CD154, the ligand of CD40, is a key mediator of inflammation. Read More

    Treatment of Annular Elastolytic Giant Cell Granuloma With Topical Tretinoin.
    J Drugs Dermatol 2017 Jul;16(7):699-700

    Annular elastolytic giant cell granuloma, also known as actinic granuloma, is a rare skin condition with a chronic course that is often resistant to treatment. Literature is sparse, and only a handful of case reports are available to guide treatment decisions. Typical first line treatment options include topical and intralesional steroids, topical pimecrolimus, and cryotherapy. Read More


    [Anatomoclinical study of annular elastolytic giant cell granuloma].
    Ann Dermatol Venereol 2017 Oct 27;144(10):589-598. Epub 2017 Jun 27.
    Clinique dermatologique, université de Strasbourg, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France.
    Background: Annular elastolytic giant cell granuloma (AEGCG), a rare entity first described in 1979, is very similar to O'Brien actinic granuloma (AG), first described in 1975. Since then, many cases have been published under one or other of the two names. We performed a single-centre histopathology study to identify the distinguishing features and determine whether there was any objective difference between AEGCG and AG. Read More

    Phosphaturic Mesenchymal Tumors: Clinicopathologic, Immunohistochemical and Molecular Analysis of 22 Cases Expanding their Morphologic and Immunophenotypic Spectrum.
    Am J Surg Pathol 2017 Oct;41(10):1371-1380
    *Institute of Pathology ††Department of Hand & Plastic Surgery, University Hospital, Erlangen **Institute of Pathology ‡‡Department of Orthopedic & Traumatology, Section for Tumor Orthopedics, University Hospital, Bonn, Germany †Department of Pathology, Faculty of Medicine in Pilsen, Charles University, Prague ‡Biomedical Center of the Faculty of Medicine in Pilsen, Pilsen, Czech Republic §Department of Pathology, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA ∥Department of Pathology, National University Health System, Singapore ¶Department of Pathology, 3rd Medical Faculty in Prague, Charles University, Prague, Czech Republic.
    Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm of uncertain histogenesis that has been linked to tumor-induced osteomalacia (TIO) since 1959. The neoplastic cells produce increased amount of FGF23 which results in TIO via uncontrolled renal loss of phosphate (phosphaturia), and consequently diminished bone mineralization. To date, ∼300 cases have been reported. Read More

    [Granulomatous reaction pattern of the skin : Interstitial granulomatous dermatitis - lymphoma - vasculitis].
    Hautarzt 2017 Jul;68(7):553-559
    Konsultations- und Referenzzentrum für Vaskulitis-Diagnostik, MVZ am Marienkrankenhaus gGmbH, Hamburg, Deutschland.
    A particular diagnostic situation in the classification of a granulomatous dermatitis results when no circumscribed granulomas but instead a diffuse interstitial histiocytic inflammatory infiltrate, a granulomatous vasculitis or a neoplastic lymphocytic infiltrate is found. Interstitial granulomatous dermatitis was originally described in patients with arthritis. Later, it was recognized that there are also associations with other usually immunological diseases. Read More

    [Giant cell-rich lesions of bone and their differential diagnosis].
    Cesk Patol 2017 ;53(2):61-70
    Giant cell-rich lesions form a heterogeneous group of reactive and truly neoplastic processes with diverse clinical presentation and biological behavior. Common to all of them are variably numerous multinucleated osteoclast-like giant cells and the presence of mononuclear stroma. Based on the histological picture alone it is sometimes impossible to reliably distinguish certain tumors from each other. Read More

    Cholesterol Granuloma of the Abdominal Wall: An Unusual Finding in the Setting of Renal Cell Carcinoma.
    Urol Case Rep 2017 Jul 29;13:160-161. Epub 2017 May 29.
    University of Texas Medical Branch, Department of Surgery, Division of Urology, 301 University Blvd, Galveston, TX 77555-0764, USA.
    Cholesterol granulomas are composed of a distinct type of granulation tissue that contains lipids and cholesterol crystals. They are not believed to be a pathological entity, but rather an inflammatory tissue reaction to the presence of trapped blood secondary to localized hemorrhage.(1) Cholesterol granulomas can be identified histologically by the presence of multi-nucleated giant cells, hemosiderin, and red blood cells along with their associated break-down products. Read More

    Benign Bone Conditions That May Be FDG-avid and Mimic Malignancy.
    Semin Nucl Med 2017 Jul 12;47(4):322-351. Epub 2017 Apr 12.
    Department of Radiology and Nuclear Medicine, Deventer Ziekenhuis, Deventer, The Netherlands.
    Positron emission tomography with the radiotracer (18)F-fluoro-2-deoxy-d-glucose (FDG) plays an important role in the evaluation of bone pathology. However, FDG is not a cancer-specific agent, and knowledge of the differential diagnosis of benign FDG-avid bone alterations that may resemble malignancy is important for correct patient management, including the avoidance of unnecessary additional invasive tests such as bone biopsy. This review summarizes and illustrates the spectrum of benign bone conditions that may be FDG-avid and mimic malignancy, including osteomyelitis, bone lesions due to benign systemic diseases (Brown tumor, Erdheim-Chester disease, Gaucher disease, gout and other types of arthritis, Langerhans cell histiocytosis, and sarcoidosis), benign primary bone lesions (bone cysts, chondroblastoma, chondromyxoid fibroma, desmoplastic fibroma, enchondroma, giant cell tumor and granuloma, hemangioma, nonossifying fibroma, and osteoid osteoma and osteoblastoma), and a group of miscellaneous benign bone conditions (post bone marrow biopsy or harvest status, bone marrow hyperplasia, fibrous dysplasia, fractures, osteonecrosis, Paget disease of bone, particle disease, and Schmorl nodes). Read More

    Florid cemento-osseous dysplasia and peripheral giant cell granuloma in a patient with neurofibromatosis 1.
    An Bras Dermatol 2017 Mar-Apr;92(2):249-252
    Department of Oral Pathology, Universidade Federal do Rio Grande do Norte (UFRN) - Natal (RN), Brazil.
    We report a 35-year-old mulatto female patient with neurofibromatosis Type 1 who presented with facial asymmetry. The patient had two lesions: florid cemento-osseous dysplasia associated with peripheral giant cell granuloma. She was referred for surgical treatment of the peripheral giant cell granuloma and the florid cemento-osseous dysplasia was treated conservatively by a multidisciplinary team. Read More

    Teflon granuloma after microvascular decompression for hemifacial spasm: a case report and literature review.
    Neurosurg Rev 2017 Jul 22;40(3):513-516. Epub 2017 May 22.
    Department of Neurological Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-Ku, Tokyo, 113-8603, Japan.
    Teflon has been commonly used as a surgical material. In particular, Teflon has been considered suitable for microvascular decompression of cranial nerves, as it is a stable, inert substance that does not resorb or migrate. Giant cell foreign body reactions after microvascular decompression (MVD) have been reported, but this rare complication has not been well recognized. Read More

    Metastasis of a Renal Collecting Duct Adenocarcinoma to the Oral Cavity After Tooth Extraction.
    J Craniofac Surg 2017 Jun;28(4):e398-e399
    *Department of Pathology, Faculty of Medicine †Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University, Gaziantep ‡Department of Pathology, Faculty of Medicine, TOBB Economics and Technology, Ankara, Turkey.
    Metastatic tumors rarely occur in the oral cavity. The most common of the oral metastases are lung cancers in males, and breast and genital cancers in females. The most common primary tumor metastasis to the oral cavity is from the lung, kidney, liver, prostate, and colorectal cancers. Read More

    Concomitant Central Giant Cell Granuloma and Aneurysmal Bone Cyst in a Young Child.
    Case Rep Dent 2017 5;2017:6545848. Epub 2017 Apr 5.
    Department of Oral and Maxillofacial Surgery, Mahe Institute of Dental Sciences, Puducherry, Kerala, India.
    Although Central Giant Cell Granuloma (CGCG) is a benign tumor of the jaw and aneurysmal bone cyst seen in children, its aggressive behavior causes extensive loss of hard tissue requiring wide excision and extensive rehabilitation. We report a rare case of concomitant CGCG and aneurysmal bone cyst in a two-year-old male child, involving the coronoid and condylar process. Young age, large tumor, its aggressive nature, and future growth of orofacial region pose a significant challenge in the management of such conditions. Read More

    Assessment of reactive gingival lesions of oral cavity: A histopathological study.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):180
    Department of Oral and Maxillofacial Pathology, Navodaya Dental College, Raichur, Karnataka, India.
    Background: In the literature, many studies were attempted to analyze the distribution of oral reactive lesions in terms of age, gender and location. However, very few studies have focused on the detailed histopathological features of these reactive lesions of oral cavity. Thus, the purpose of this paper is to document the occurrence, distribution and various histopathological features of reactive gingival lesions. Read More

    Giant Cell Reparative Granuloma Mimicking Aneurysmal Bone Cyst in Proximal Phalanx of Toe.
    Malays Orthop J 2016 Mar;10(1):55-56
    Department of Orthopaedics, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan Malaysia.
    Giant Cell Reparative Granuloma (GCRG) of phalanx is uncommon. It is a benign osteolytic lesion but can be locally aggressive. GCRG has certain radiology and histological features that are similar to other giant cell lesions of the bone. Read More

    The effect of thymoquinone coating on adhesive properties of polypropylene mesh.
    BMC Surg 2017 Apr 17;17(1):40. Epub 2017 Apr 17.
    Department of Pathology, Kirikkale University Medical Faculty, Tahsin Duru Cad. No:14, Yenisehir, Yahsihan, 71450, Kirikkale, Turkey.
    Background: An incisional hernia is a common complication following abdominal surgery. Polypropylene mesh is frequently used in the repair of such defects and has nearly become the standard surgical treatment modality. Though they are very effective in reducing recurrence, mesh materials exhibit a strong stimulating effect for intraabdominal adhesion. Read More

    A case of splenomegaly in CBL syndrome.
    Eur J Med Genet 2017 Jul 13;60(7):374-379. Epub 2017 Apr 13.
    British Columbia Children's Hospital Research Institute, Vancouver, Canada; Centre for Molecular Medicine & Therapeutics, University of British Columbia, Vancouver, Canada; Treatable Intellectual Disability Endeavour in British Columbia (TIDE-BC), Vancouver, Canada; Department of Pediatrics, University of British Columbia, Vancouver, Canada; Department of Pediatrics, Emma Children's Hospital, Academic Medical Centre, Amsterdam, The Netherlands. Electronic address:
    Introduction: We present a child with unexplained splenomegaly to highlight this feature as a presenting sign of the RASopathy CBL syndrome and to draw attention to the power and utility of next generation genomic sequencing for providing rapid diagnosis and critical information to guide care in the pediatric clinical setting.

    Clinical Report: A 7-year-old boy presented with unexplained splenomegaly, attention deficit hyperactivity disorder, mild learning difficulties, easy bruising, mild thrombocytopenia, and subtle dysmorphic features. Extensive haematological testing including a bone marrow biopsy showed mild megaloblastoid erythropoiesis and borderline fibrosis. Read More

    [Granulomatous periocular eruption].
    Ann Dermatol Venereol 2017 Jun - Jul;144(6-7):430-433. Epub 2017 Apr 12.
    Clinique universitaire de dermatologie, allergologie et photobiologie, CHU de Grenoble, boulevard de la Chantourne, 38700 La Tronche, France.
    Background: Herein, we report a case of atypical periorificial dermatitis in a patient that had been receiving treatment for some time for atopic dermatitis. The specific feature of this rash was its periocular predominance with no perioral involvement, its clinical aspect and its histological picture evocative of sarcoidosis.

    Patients And Methods: A 33-year-old man was being treated for a atopic dermatitis limited to the face and poorly responsive to dermal corticosteroids. Read More

    Combination therapies for the treatment of recurrent central giant cell lesion in the maxilla: a case report.
    J Med Case Rep 2017 Mar 20;11(1):74. Epub 2017 Mar 20.
    Universidade Positivo, 5300 Prof. Pedro Viriato Parigot de Souza St., Campo Comprido, Curitiba, PR, 81280-330, Brazil.
    Background: Central giant cell lesion is a non-neoplastic proliferation, usually asymptomatic, of unknown etiology. The purpose of this case report is to report the diagnosis and the treatment of a recurrent central giant cell lesion in the maxilla.

    Case Presentation: A 31-year-old Brazilian woman presented to our Surgery Service for evaluation of a cystic lesion in her teeth 13 and 15, although she had previously received endodontic treatment for her teeth 13 and 15 without regression of the lesion. Read More

    Annular Elastolytic Giant Cell Granuloma Successfully Treated With Adalimumab Subsequently Complicated by Drug-Induced Lupus.
    J Drugs Dermatol 2017 Feb;16(2):169-171
    We report a 51-year-old female with a 3-year history of recalcitrant annular elastolytic giant cell granuloma (AEGCG) who was effectively treated with the anti-tumor necrosis factor (TNF)-alpha antibody, adalimumab. Her disease was refractory to topical glucocorticoids, intralesional glucocorticoids, narrow-band ultraviolet light (UV)-B phototherapy and cyclosporine. During her treatment with adalimumab she developed a positive anti-nuclear-antibody and double-stranded-DNA antibody and her treatment was terminated. Read More

    Pseudotumoral form of soft tissue tuberculosis of the hand: six cases.
    Pan Afr Med J 2016 21;25:178. Epub 2016 Nov 21.
    Orthopedic surgery and Trauma Department, Maamouri Hospital, Nabeul, Tunisia.
    Musculoskeletal involvement is not uncommon in extra-pulmonary tuberculosis, but the localization in the soft tissue of the hand is very rare. Diagnosis is much more difficult because of the atypical location and non-specific symptoms. We report 6 cases of pseudotumoral form of soft tissue tuberculosis of the hand treated in our department during the past 12 years. Read More

    A Giant-Cell Lesion with Cellular Cannibalism in the Mandible: Case Report and Review of Brown Tumors in Hyperparathyroidism.
    Case Rep Dent 2017 9;2017:9604570. Epub 2017 Feb 9.
    Department of Surgical and Morphological Sciences, University of Insubria, ASST dei Sette Laghi, Unit of Oral Pathology, Dental Clinic, Varese, Italy.
    A small radiolucent area in the mandible was discovered in a 58-year-old woman with no oral complaints. The patient's history included only hypertension. The lesion was considered as an inflammatory cyst and was enucleated. Read More

    [Giant cell reparative granuloma of the metacarpal bone : Diagnostic difficulties].
    Unfallchirurg 2017 Mar 3. Epub 2017 Mar 3.
    Klinik für Unfallchirurgie, Klinikum Passau, Innstraße 76, 94032, Passau, Deutschland.
    Giant cell reparative granuloma (GCRG) is benign, non-tumorous granulation tissue. It mainly arises in the jaw bone and occasionally in the hand and foot. Because of the high rate of recurrence, wide surgical resection and autologous bone grafting are recommended. Read More

    Osteolysis of the Greater Trochanter Caused by a Foreign Body Granuloma Associated with the Ethibond® Suture after Total Hip Arthroplasty.
    Case Rep Orthop 2017 31;2017:6082302. Epub 2017 Jan 31.
    Akita Hip Research Group (AHRG), Akita, Japan; Department of Orthopedic Surgery, Akita University Graduate School of Medicine, Akita, Japan.
    The present case shows a case of progression of osteolysis of the greater trochanter caused by a foreign body granuloma associated with the number 5 Ethibond suture in cementless THA with the direct lateral approach that was completely healed by removal of the Ethibond suture. A 55-year-old Japanese woman with secondary osteoarthritis caused by acetabular dysplasia underwent left cementless THA with the direct lateral approach. After setting of the total hip prosthesis, the gluteus medius muscle and vastus lateralis muscle were reattached to the greater trochanter through two bone tunnels using number 5 Ethibond EXCEL sutures. Read More

    Actinic Granuloma Annulare With Scarring and Open Comedones.
    Am J Dermatopathol 2017 Aug;39(8):625-627
    *Department of Dermatology, Medical School, University of São Paulo, São Paulo, Brazil; and †Department of Pathology, Hospital Obrero, La Paz, Bolivia.
    Actinic granuloma and annular elastolytic giant cell granuloma are variants of granuloma annulare affecting, respectively, sun-exposed and sun-covered skin sites on where, besides classical findings, abundant elastophagocytosis is observed. Here, we report a case of exuberant actinic granuloma annulare that, in addition to extensive scarring, showed multiple overlying open comedones. Markedly dilated follicular infundibula filled with compact masses of laminated keratinous material were observed in proximity to dermal inflammation composed of many histiocytes and multinucleated giant cells in close association with degenerated elastic fibers and abundant elastophagocytosis. Read More

    Spectrum and clinical variants of giant cell elastolytic granuloma.
    Int J Dermatol 2017 Jul 27;56(7):738-745. Epub 2017 Feb 27.
    Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan.
    Background: Giant cell elastolytic granuloma, also known as annular elastolytic giant cell granuloma or actinic granuloma, is histologically characterized by elastophagocytosis. Recent studies have revealed various clinical presentations in both sun-exposed and non-sun-exposed areas.

    Objectives: To clarify clinical characteristics based on case series observation. Read More

    Histological evaluation of the possible transformation of peripheral giant cell granuloma and peripheral ossifying fibroma: A preliminary study.
    Indian J Pathol Microbiol 2017 Jan-Mar;60(1):15-20
    Department of Pathology, Gülhane Military Medical Academy, Ankara, Turkey.
    Aims: The objective of this study is to describe shared morphological features of peripheral giant cell granuloma (PGCG) and peripheral ossifying fibroma (POF) in detail and discuss the possible relationship between them.

    Materials And Methods: Ten intermediate cases with features resembling to both POF and PGCG were selected and type 3 and 1 collagen immunostainings were performed for evaluation of the connective tissue maturation. Immunohistochemical staining percentage (SP) for stromal cells in the slides of POF and PGCG counterparts of intermediate lesions was scored as 1 when the SP was above 10%, 2 when the SP was above 25%, 3 when the SP was above 50% and 4 when the SP was above 75%. Read More

    Mycolates of Mycobacterium tuberculosis modulate the flow of cholesterol for bacillary proliferation in murine macrophages.
    J Lipid Res 2017 Apr 13;58(4):709-718. Epub 2017 Feb 13.
    Laboratory of Molecular Immunology, Department of Biomedical Molecular Biology, Ghent University, Ghent Zwijnaarde 9052, Belgium
    The differentiation of macrophages into lipid-filled foam cells is a hallmark of the lung granuloma that forms in patients with active tuberculosis (TB). Mycolic acids (MAs), the abundant lipid virulence factors in the cell wall of Mycobacterium tuberculosis (Mtb), can induce this foam phenotype possibly as a way to perturb host cell lipid homeostasis to support the infection. It is not exactly clear how MAs allow differentiation of foam cells during Mtb infection. Read More

    Age and Expression of CD163 and Colony-Stimulating Factor 1 Receptor (CD115) Are Associated With the Biological Behavior of Central Giant Cell Granuloma.
    J Oral Maxillofac Surg 2017 Jul 9;75(7):1414-1424. Epub 2017 Jan 9.
    Associate Professor and Head, Department of Oral Pathology and Oral Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
    Purpose: Central giant cell granulomas (CGCGs) are clinically classified as nonaggressive (nA-CGCGs) and aggressive (A-CGCGs). However, histopathologically, all lesions feature spindle mononuclear cells (MCs) and multinuclear giant cells (GCs) in a hemorrhage-rich stroma. We aimed to investigate the presence of cells with a monocyte- or macrophage-related phenotype and, together with clinical variables, to examine their predictive potential for the biological behavior of CGCGs. Read More

    Patients with benign hand tumors are indicated for surgery according to patient-rated outcome measures.
    J Plast Reconstr Aesthet Surg 2017 Apr 9;70(4):487-494. Epub 2017 Jan 9.
    Department of Hand Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
    Introduction: This study assessed the treatment outcomes of upper extremity benign tumors using the patient-rated outcome measures of Hand20 questionnaire.

    Methods: In total, 304 patients who underwent surgery for benign bone and soft tissue tumors of the upper limb were included. Tumors were classified into three size groups: <1 cm, 1-3 cm, and >3 cm. Read More

    Radiologic-Pathologic Correlation of Primary and Secondary Cardiomyopathies: MR Imaging and Histopathologic Findings in Hearts from Autopsy and Transplantation.
    Radiographics 2017 May-Jun;37(3):719-736. Epub 2017 Jan 27.
    From the Departments of Radiology (H.H., Y.M., M.H., H.N.) and Pathology (H.H., H.I.U.), National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, Japan; Departments of Diagnostic Radiology (F.K.), Cardiology (S.N.), and Cardiovascular Surgery (A.I.), Saitama Medical University International Medical Center, Hidaka, Japan; Department of Radiology, Tenri Hospital, Tenri, Japan (K.U.); and Department of Radiology, Kobe University, Kobe, Japan (K.S.).
    Cardiac magnetic resonance (MR) imaging with late gadolinium enhancement (LGE) is used to detect and assess the myocardial damage seen with a variety of cardiomyopathies. Gadolinium-based contrast material accumulates in the expanded interstitial space of the myocardium. Areas with LGE correspond to replacement fibrosis, fibrofatty change, epithelioid granuloma, inflammatory cell infiltration, cardiomyocyte necrosis, and amyloid deposition-conditions that represent a focal increase in interstitial space. Read More

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