Am J Surg Pathol 2017 Jun 13. Epub 2017 Jun 13.

*Institute of Pathology ††Department of Hand & Plastic Surgery, University Hospital, Erlangen **Institute of Pathology ‡‡Department of Orthopedic & Traumatology, Section for Tumor Orthopedics, University Hospital, Bonn, Germany †Department of Pathology, Faculty of Medicine in Pilsen, Charles University, Prague ‡Biomedical Center of the Faculty of Medicine in Pilsen, Pilsen, Czech Republic §Department of Pathology, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA ∥Department of Pathology, National University Health System, Singapore ¶Department of Pathology, 3rd Medical Faculty in Prague, Charles University, Prague, Czech Republic.

Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm of uncertain histogenesis that has been linked to tumor-induced osteomalacia (TIO) since 1959. The neoplastic cells produce increased amount of FGF23 which results in TIO via uncontrolled renal loss of phosphate (phosphaturia), and consequently diminished bone mineralization. To date, ∼300 cases have been reported. Read More

Hautarzt 2017 Jun 12. Epub 2017 Jun 12.

Konsultations- und Referenzzentrum für Vaskulitis-Diagnostik, MVZ am Marienkrankenhaus gGmbH, Hamburg, Deutschland.

A particular diagnostic situation in the classification of a granulomatous dermatitis results when no circumscribed granulomas but instead a diffuse interstitial histiocytic inflammatory infiltrate, a granulomatous vasculitis or a neoplastic lymphocytic infiltrate is found. Interstitial granulomatous dermatitis was originally described in patients with arthritis. Later, it was recognized that there are also associations with other usually immunological diseases. Read More

Cesk Patol 2017 ;53(2):61-70

Giant cell-rich lesions form a heterogeneous group of reactive and truly neoplastic processes with diverse clinical presentation and biological behavior. Common to all of them are variably numerous multinucleated osteoclast-like giant cells and the presence of mononuclear stroma. Based on the histological picture alone it is sometimes impossible to reliably distinguish certain tumors from each other. Read More

Urol Case Rep 2017 Jul 29;13:160-161. Epub 2017 May 29.

University of Texas Medical Branch, Department of Surgery, Division of Urology, 301 University Blvd, Galveston, TX 77555-0764, USA.

Cholesterol granulomas are composed of a distinct type of granulation tissue that contains lipids and cholesterol crystals. They are not believed to be a pathological entity, but rather an inflammatory tissue reaction to the presence of trapped blood secondary to localized hemorrhage.(1) Cholesterol granulomas can be identified histologically by the presence of multi-nucleated giant cells, hemosiderin, and red blood cells along with their associated break-down products. Read More

Semin Nucl Med 2017 Jul 12;47(4):322-351. Epub 2017 Apr 12.

Department of Radiology and Nuclear Medicine, Deventer Ziekenhuis, Deventer, The Netherlands.

Positron emission tomography with the radiotracer (18)F-fluoro-2-deoxy-d-glucose (FDG) plays an important role in the evaluation of bone pathology. However, FDG is not a cancer-specific agent, and knowledge of the differential diagnosis of benign FDG-avid bone alterations that may resemble malignancy is important for correct patient management, including the avoidance of unnecessary additional invasive tests such as bone biopsy. This review summarizes and illustrates the spectrum of benign bone conditions that may be FDG-avid and mimic malignancy, including osteomyelitis, bone lesions due to benign systemic diseases (Brown tumor, Erdheim-Chester disease, Gaucher disease, gout and other types of arthritis, Langerhans cell histiocytosis, and sarcoidosis), benign primary bone lesions (bone cysts, chondroblastoma, chondromyxoid fibroma, desmoplastic fibroma, enchondroma, giant cell tumor and granuloma, hemangioma, nonossifying fibroma, and osteoid osteoma and osteoblastoma), and a group of miscellaneous benign bone conditions (post bone marrow biopsy or harvest status, bone marrow hyperplasia, fibrous dysplasia, fractures, osteonecrosis, Paget disease of bone, particle disease, and Schmorl nodes). Read More

An Bras Dermatol 2017 Mar-Apr;92(2):249-252

Department of Oral Pathology, Universidade Federal do Rio Grande do Norte (UFRN) - Natal (RN), Brazil.

We report a 35-year-old mulatto female patient with neurofibromatosis Type 1 who presented with facial asymmetry. The patient had two lesions: florid cemento-osseous dysplasia associated with peripheral giant cell granuloma. She was referred for surgical treatment of the peripheral giant cell granuloma and the florid cemento-osseous dysplasia was treated conservatively by a multidisciplinary team. Read More

Neurosurg Rev 2017 Jul 22;40(3):513-516. Epub 2017 May 22.

Department of Neurological Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-Ku, Tokyo, 113-8603, Japan.

Teflon has been commonly used as a surgical material. In particular, Teflon has been considered suitable for microvascular decompression of cranial nerves, as it is a stable, inert substance that does not resorb or migrate. Giant cell foreign body reactions after microvascular decompression (MVD) have been reported, but this rare complication has not been well recognized. Read More

J Craniofac Surg 2017 Jun;28(4):e398-e399

*Department of Pathology, Faculty of Medicine †Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University, Gaziantep ‡Department of Pathology, Faculty of Medicine, TOBB Economics and Technology, Ankara, Turkey.

Metastatic tumors rarely occur in the oral cavity. The most common of the oral metastases are lung cancers in males, and breast and genital cancers in females. The most common primary tumor metastasis to the oral cavity is from the lung, kidney, liver, prostate, and colorectal cancers. Read More

Case Rep Dent 2017 5;2017:6545848. Epub 2017 Apr 5.

Department of Oral and Maxillofacial Surgery, Mahe Institute of Dental Sciences, Puducherry, Kerala, India.

Although Central Giant Cell Granuloma (CGCG) is a benign tumor of the jaw and aneurysmal bone cyst seen in children, its aggressive behavior causes extensive loss of hard tissue requiring wide excision and extensive rehabilitation. We report a rare case of concomitant CGCG and aneurysmal bone cyst in a two-year-old male child, involving the coronoid and condylar process. Young age, large tumor, its aggressive nature, and future growth of orofacial region pose a significant challenge in the management of such conditions. Read More

J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):180

Department of Oral and Maxillofacial Pathology, Navodaya Dental College, Raichur, Karnataka, India.

Background: In the literature, many studies were attempted to analyze the distribution of oral reactive lesions in terms of age, gender and location. However, very few studies have focused on the detailed histopathological features of these reactive lesions of oral cavity. Thus, the purpose of this paper is to document the occurrence, distribution and various histopathological features of reactive gingival lesions. Read More

Malays Orthop J 2016 Mar;10(1):55-56

Department of Orthopaedics, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan Malaysia.

Giant Cell Reparative Granuloma (GCRG) of phalanx is uncommon. It is a benign osteolytic lesion but can be locally aggressive. GCRG has certain radiology and histological features that are similar to other giant cell lesions of the bone. Read More

BMC Surg 2017 Apr 17;17(1):40. Epub 2017 Apr 17.

Department of Pathology, Kirikkale University Medical Faculty, Tahsin Duru Cad. No:14, Yenisehir, Yahsihan, 71450, Kirikkale, Turkey.

Background: An incisional hernia is a common complication following abdominal surgery. Polypropylene mesh is frequently used in the repair of such defects and has nearly become the standard surgical treatment modality. Though they are very effective in reducing recurrence, mesh materials exhibit a strong stimulating effect for intraabdominal adhesion. Read More

Ann Dermatol Venereol 2017 Jun - Jul;144(6-7):430-433. Epub 2017 Apr 12.

Clinique universitaire de dermatologie, allergologie et photobiologie, CHU de Grenoble, boulevard de la Chantourne, 38700 La Tronche, France.

Background: Herein, we report a case of atypical periorificial dermatitis in a patient that had been receiving treatment for some time for atopic dermatitis. The specific feature of this rash was its periocular predominance with no perioral involvement, its clinical aspect and its histological picture evocative of sarcoidosis.

Patients And Methods: A 33-year-old man was being treated for a atopic dermatitis limited to the face and poorly responsive to dermal corticosteroids. Read More

J Drugs Dermatol 2017 Feb;16(2):169-171

We report a 51-year-old female with a 3-year history of recalcitrant annular elastolytic giant cell granuloma (AEGCG) who was effectively treated with the anti-tumor necrosis factor (TNF)-alpha antibody, adalimumab. Her disease was refractory to topical glucocorticoids, intralesional glucocorticoids, narrow-band ultraviolet light (UV)-B phototherapy and cyclosporine. During her treatment with adalimumab she developed a positive anti-nuclear-antibody and double-stranded-DNA antibody and her treatment was terminated. Read More

Pan Afr Med J 2016 21;25:178. Epub 2016 Nov 21.

Orthopedic surgery and Trauma Department, Maamouri Hospital, Nabeul, Tunisia.

Musculoskeletal involvement is not uncommon in extra-pulmonary tuberculosis, but the localization in the soft tissue of the hand is very rare. Diagnosis is much more difficult because of the atypical location and non-specific symptoms. We report 6 cases of pseudotumoral form of soft tissue tuberculosis of the hand treated in our department during the past 12 years. Read More

Case Rep Dent 2017 9;2017:9604570. Epub 2017 Feb 9.

Department of Surgical and Morphological Sciences, University of Insubria, ASST dei Sette Laghi, Unit of Oral Pathology, Dental Clinic, Varese, Italy.

A small radiolucent area in the mandible was discovered in a 58-year-old woman with no oral complaints. The patient's history included only hypertension. The lesion was considered as an inflammatory cyst and was enucleated. Read More

Unfallchirurg 2017 Mar 3. Epub 2017 Mar 3.

Klinik für Unfallchirurgie, Klinikum Passau, Innstraße 76, 94032, Passau, Deutschland.

Giant cell reparative granuloma (GCRG) is benign, non-tumorous granulation tissue. It mainly arises in the jaw bone and occasionally in the hand and foot. Because of the high rate of recurrence, wide surgical resection and autologous bone grafting are recommended. Read More

Case Rep Orthop 2017 31;2017:6082302. Epub 2017 Jan 31.

Akita Hip Research Group (AHRG), Akita, Japan; Department of Orthopedic Surgery, Akita University Graduate School of Medicine, Akita, Japan.

The present case shows a case of progression of osteolysis of the greater trochanter caused by a foreign body granuloma associated with the number 5 Ethibond suture in cementless THA with the direct lateral approach that was completely healed by removal of the Ethibond suture. A 55-year-old Japanese woman with secondary osteoarthritis caused by acetabular dysplasia underwent left cementless THA with the direct lateral approach. After setting of the total hip prosthesis, the gluteus medius muscle and vastus lateralis muscle were reattached to the greater trochanter through two bone tunnels using number 5 Ethibond EXCEL sutures. Read More

Am J Dermatopathol 2017 Feb 14. Epub 2017 Feb 14.

*Department of Dermatology, Medical School, University of São Paulo, São Paulo, Brazil; and †Department of Pathology, Hospital Obrero, La Paz, Bolivia.

Actinic granuloma and annular elastolytic giant cell granuloma are variants of granuloma annulare affecting, respectively, sun-exposed and sun-covered skin sites on where, besides classical findings, abundant elastophagocytosis is observed. Here, we report a case of exuberant actinic granuloma annulare that, in addition to extensive scarring, showed multiple overlying open comedones. Markedly dilated follicular infundibula filled with compact masses of laminated keratinous material were observed in proximity to dermal inflammation composed of many histiocytes and multinucleated giant cells in close association with degenerated elastic fibers and abundant elastophagocytosis. Read More

Int J Dermatol 2017 Jul 27;56(7):738-745. Epub 2017 Feb 27.

Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan.

Background: Giant cell elastolytic granuloma, also known as annular elastolytic giant cell granuloma or actinic granuloma, is histologically characterized by elastophagocytosis. Recent studies have revealed various clinical presentations in both sun-exposed and non-sun-exposed areas.

Objectives: To clarify clinical characteristics based on case series observation. Read More

Indian J Pathol Microbiol 2017 Jan-Mar;60(1):15-20

Department of Pathology, Gülhane Military Medical Academy, Ankara, Turkey.

Aims: The objective of this study is to describe shared morphological features of peripheral giant cell granuloma (PGCG) and peripheral ossifying fibroma (POF) in detail and discuss the possible relationship between them.

Materials And Methods: Ten intermediate cases with features resembling to both POF and PGCG were selected and type 3 and 1 collagen immunostainings were performed for evaluation of the connective tissue maturation. Immunohistochemical staining percentage (SP) for stromal cells in the slides of POF and PGCG counterparts of intermediate lesions was scored as 1 when the SP was above 10%, 2 when the SP was above 25%, 3 when the SP was above 50% and 4 when the SP was above 75%. Read More

J Lipid Res 2017 Apr 13;58(4):709-718. Epub 2017 Feb 13.

Laboratory of Molecular Immunology, Department of Biomedical Molecular Biology, Ghent University, Ghent Zwijnaarde 9052, Belgium

The differentiation of macrophages into lipid-filled foam cells is a hallmark of the lung granuloma that forms in patients with active tuberculosis (TB). Mycolic acids (MAs), the abundant lipid virulence factors in the cell wall of Mycobacterium tuberculosis (Mtb), can induce this foam phenotype possibly as a way to perturb host cell lipid homeostasis to support the infection. It is not exactly clear how MAs allow differentiation of foam cells during Mtb infection. Read More

J Oral Maxillofac Surg 2017 Jul 9;75(7):1414-1424. Epub 2017 Jan 9.

Associate Professor and Head, Department of Oral Pathology and Oral Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: Central giant cell granulomas (CGCGs) are clinically classified as nonaggressive (nA-CGCGs) and aggressive (A-CGCGs). However, histopathologically, all lesions feature spindle mononuclear cells (MCs) and multinuclear giant cells (GCs) in a hemorrhage-rich stroma. We aimed to investigate the presence of cells with a monocyte- or macrophage-related phenotype and, together with clinical variables, to examine their predictive potential for the biological behavior of CGCGs. Read More

J Plast Reconstr Aesthet Surg 2017 Apr 9;70(4):487-494. Epub 2017 Jan 9.

Department of Hand Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.

Introduction: This study assessed the treatment outcomes of upper extremity benign tumors using the patient-rated outcome measures of Hand20 questionnaire.

Methods: In total, 304 patients who underwent surgery for benign bone and soft tissue tumors of the upper limb were included. Tumors were classified into three size groups: <1 cm, 1-3 cm, and >3 cm. Read More

Radiographics 2017 May-Jun;37(3):719-736. Epub 2017 Jan 27.

From the Departments of Radiology (H.H., Y.M., M.H., H.N.) and Pathology (H.H., H.I.U.), National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, Japan; Departments of Diagnostic Radiology (F.K.), Cardiology (S.N.), and Cardiovascular Surgery (A.I.), Saitama Medical University International Medical Center, Hidaka, Japan; Department of Radiology, Tenri Hospital, Tenri, Japan (K.U.); and Department of Radiology, Kobe University, Kobe, Japan (K.S.).

Cardiac magnetic resonance (MR) imaging with late gadolinium enhancement (LGE) is used to detect and assess the myocardial damage seen with a variety of cardiomyopathies. Gadolinium-based contrast material accumulates in the expanded interstitial space of the myocardium. Areas with LGE correspond to replacement fibrosis, fibrofatty change, epithelioid granuloma, inflammatory cell infiltration, cardiomyocyte necrosis, and amyloid deposition-conditions that represent a focal increase in interstitial space. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jan;52(1):65-66

Department of Otorhinolaryngology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China.

J Dent Res Dent Clin Dent Prospects 2016 21;10(4):241-246. Epub 2016 Dec 21.

Postgraduate Student, Biotechnology Research Center and Department of Orthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Background. Reliable immunohistochemical assays to assess the definitive role of mast cells (MCs) and angiogenesis in the pathogenesis of oral reactive lesions are generally not available. The aim of the present study was to evaluate mast cell counts (MCC) and microvessel density (MVD) in oral reactive lesions and determine the correlation between MCC and MVD. Read More

Int J Surg Case Rep 2017 17;30:222-225. Epub 2016 Nov 17.

Department of the Oral & Maxillofacial Surgery, kalka Dental College & Hospital, Meerut India College of Medicine & J.N.M. Hospital, West Bengal India.

Introduction: Central Giant Cell Granuloma (CGCG) is an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of hemorrhage, aggregations of multinucleated giant cells and occasionally trabeculae of woven bone1.

Presentation Of Case: we are presenting a case of Central Giant Cell Granuloma on Maxilla. Extra oral examination revealed a diffuse swelling on the left side of face causing slight obliteration of nasio - nasolabial labial fold resulting in facial asymmetry & Intraoral examination shows a purple expansile mass in the region of upper left 26, 27 and 28 edentulous areas. Read More

J Craniomaxillofac Surg 2017 Feb 9;45(2):232-243. Epub 2016 Dec 9.

Department of Oral and Maxillofacial Surgery (Head: Prof. J. de Lange), Academic Medical Center, Academic Center Dentistry Amsterdam and University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. Electronic address:

Purpose: This is a retrospective cohort study of patients with a central giant cell granuloma (CGCG) treated at a single center to assess and compare the different surgical and non-surgical approaches.

Material And Methods: A cohort with a single histologically proven non-syndrome-related CGCG was selected and reviewed. Patients were allocated to group I (surgery), group II (pharmacotherapy), and group III (pharmacotherapy and surgery). Read More

ACS Nano 2017 Jan 11;11(1):291-303. Epub 2017 Jan 11.

Institute of Environmental Medicine (IMM), Karolinska Institutet , Stockholm 171 77, Sweden.

Carbon nanotubes (CNTs) have the potential to impact technological and industrial progress, but their production and use may, in some cases, cause serious health problems. Certain rod-shaped multiwalled CNTs (rCNTs) can, in fact, induce severe asbestos-like pathogenicity in mice, including granuloma formation, fibrosis, and even cancer. Evaluating the comparability between alternative hazard assessment methods is needed to ensure fast and reliable evaluation of the potentially adverse effects of these materials. Read More

Case Rep Dent 2016 24;2016:6725913. Epub 2016 Nov 24.

Master's Program in Integrated Dental Sciences, University of Cuiabá, Cuiabá, MT, Brazil.

Peripheral giant cell granuloma (PGCG) is a nonneoplastic lesion that may affect any region of the gingiva or alveolar mucosa of edentulous and toothed areas, preferentially in the mandible and rarely occurring in children. This report describes the clinical and histopathological findings of a PGCG diagnosed in the maxilla of a 9-year-old boy associated with a tooth erupting improperly and a traumatic habit. The patient did not present anything noteworthy on extraoral physical examination or medical history, but the habit of picking his teeth and "poking" the gingiva. Read More

Asian Pac J Allergy Immunol 2016 Dec 12. Epub 2016 Dec 12.

Marmara University School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, Turkey.

Infections due to non-tuberculous mycobacteria species are problematic for immunodeficient individuals. Mendelian susceptibility to mycobacterial diseases (MSMD) defines a group of genetic defects affecting cellular interactions and the interferon (IFN)-γ pathway. Patients with MSMD may present with a disseminated infection resulting from the Bacillus Calmette-Guerin vaccine, Mycobacterium tuberculosis complex, environmental nontuberculous mycobacteria or Salmonella species. Read More

Case Rep Dent 2016 16;2016:1945907. Epub 2016 Nov 16.

Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Sri Ramachandra University, Tamil Nadu, India.

Giant cell tumor (GCT) of bone is a giant-cell-rich bony lesion associated with abundant multinucleated osteoclast-type giant cells. It is a primary neoplasm of bone with characteristic clinical, radiological, and pathological features. It is an expansive and lytic lesion without periosteal reaction and prominent peripheral sclerosis. Read More

Int J Oral Maxillofac Surg 2017 Mar 6;46(3):403-404. Epub 2016 Dec 6.

Faculty of Dentistry, Ain Shams University, Cairo, Egypt. Electronic address:

J Reprod Infertil 2016 Oct-Dec;17(4):247-249

Department of Pathology, North Eastern Indira, Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Background: 95% of Tuberculosis (TB) of the female genital tract (FGT) is located in tissues other than the cervix. A rare case of primary TB of the cervix which was diagnosed coincidently in a patient of endometrioma was reported in this study.

Case Presentation: A 34 year old nullipara, a diagnosed case of endometrioma had a small cervical growth. Read More

Med Oral Patol Oral Cir Bucal 2017 Jan 1;22(1):e1-e6. Epub 2017 Jan 1.

Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: It is now well established that IL-4 has a central role in the development of monocytes to multinucleated giant cells (MGCs) by inducing the expression of integrins on the surface of monocytes. The aim of this study was to investigate the potential role of IL-4 in induction of β5 integrin expression in the peripheral blood samples of patients with giant cell granuloma.

Material And Methods: Monocytes were isolated from peripheral blood samples of patients with central giant cell granuloma (CGCG) and healthy controls using human Monocyte Isolation Kit II. Read More

PLoS One 2016 30;11(11):e0167471. Epub 2016 Nov 30.

Infectious Bacterial Diseases of Livestock Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, Iowa, United States of America.

The hallmark lesion of tuberculosis in humans and animals is the granuloma. The granuloma represents a distinct host cellular immune response composed of epithelioid macrophages, lymphocytes, and multinucleated giant cells, often surrounding a caseous necrotic core. Within the granuloma, host-pathogen interactions determine disease outcome. Read More

Pediatr Radiol 2017 Mar 23;47(3):361-365. Epub 2016 Nov 23.

Department of Pathology, Medical College of Wisconsin & Children's Hospital of Wisconsin, Milwaukee, WI, USA.

Noonan syndrome is a genetic disorder with variable expression of distinctive facial features, webbed neck, chest deformity, short stature, cryptorchidism and congenital heart disease. The association of Noonan syndrome and giant cell granulomas of the mandible is widely reported. However, Noonan syndrome may also be associated with single or multifocal tenosynovial giant cell tumors, also referred to as pigmented villonodular synovitis. Read More

J Oral Maxillofac Surg 2017 Apr 31;75(4):769.e1-769.e4. Epub 2016 Oct 31.

Tutor, Institute of Dental Sciences, Bhubaneswar, India.

Wuchereria bancrofti, Brugia malayi, and Brugia timori, categorized as nematodes, are responsible for causing lymphatic filariasis. Even though it can affect individuals of all age groups and both genders, it predominantly affects people of low socioeconomic strata. The filarial worms dwell in the subcutaneous tissues and lymphatics of human hosts. Read More

Eur J Dermatol 2017 Apr;27(2):178-179

Department of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, Shiga 520-2192, Japan.

Neurochirurgie 2016 Dec 17;62(6):332-335. Epub 2016 Nov 17.

Department of Neurosurgery, hôpital Nord, CHU AP-HM, 13015 Marseille, France. Electronic address:

Background And Importance: Giant cell reparative granuloma is a very rare benign osteolytic lesion. It typically arises in the mandible and rarely involves the skull.

Clinical Presentation: A 25-year-old male was admitted in August 2002 for a painless left preauricular mass of several months duration. Read More

Clin Immunol 2017 Feb 14;175:1-9. Epub 2016 Nov 14.

Department of Immunology, University College London, Royal Free Hospital NHS Trust, Pond Street, Hampstead NW3 2QG, London.

Peripheral monocytes from patients with common variable immunodeficiency (CVID) had on average a 2 fold greater tendency to form giant cells in medium without additional cytokines. Giant cell formation was faster and 3 to 5 fold higher in most CVID cells compared to normal. Addition of IL4, GMCSF, IFNγ, TNFa and both T cell and monocyte conditioned media promoted monocyte fusion of some CVID individuals over 5 fold the normal average level, with combinations of cytokines and monokines acting synergistically. Read More

J Toxicol Pathol 2016 Oct 27;29(4):261-264. Epub 2016 May 27.

Laboratory of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.

Alloxan had been recognized as having a direct nephrotoxic effect different from its diabetogenic action. We encountered previously unreported granulomatous tubulointerstitial nephritis with severe luminal and interstitial mineralization in one diabetic rat after one week of alloxan administration. Histopathologically, many dilated and occluded proximal and distal tubules were segmentally observed in the cortex and outer medulla. Read More

J Orthod 2016 Dec 22;43(4):306-313. Epub 2016 Sep 22.

a Maxillofacial Department , Royal Surrey County Hospital Foundation Trust , Guildford, Surrey , UK.

Central giant cell granuloma (CGCG) is an uncommon benign intraosseous lesion of the jaw, found predominantly in children and young adults below 30 years of age. The purpose of this article was to present a summary of the current literature and a case report of an 11-year-old boy diagnosed with an aggressive CGCG involving the anterior maxilla that was removed in 2004 and subsequently recurred almost 3 years later in 2006. The presenting features of the patient and the effect of combined surgical and orthodontic treatment for this condition are discussed. Read More

Iran J Pathol 2016 ;11(3):276-280

Dept. of Oral & Maxillofacial Pathology and Microbiology, Dr D Y Patil Dental College & Hospital, Sector 7, Nerul, Navi Mumbai, Maharashtra, India.

Central giant cell granuloma is a benign, aggressive neoplasm composed of multinucleated giant cells that almost exclusively occurs in the jaws though extra- gnathic incidence is rare. Multifocal CGCGs of the jaws are very rare and suggestive of systemic diseases such as hyperparathyroidism, an inherited syndrome such as Noonan- like multiple giant cell lesion syndrome or other disorders.Very few cases of multifocal CGCGs in the jaws without any concomitant systemic disease have been reported. Read More

J Oral Maxillofac Surg 2016 Nov 30;74(11):2200-2206. Epub 2016 Apr 30.

Assistant Professor, Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt. Electronic address:

Purpose: The aim of this study was to evaluate the efficacy of ethanolamine oleate (EO) sclerotherapy in the treatment of peripheral giant cell granuloma.

Patients And Methods: This study included 24 patients presenting with PGCGs greater than 2 cm in diameter. Definitive diagnosis was confirmed after histopathologic examination of incisional biopsy specimens. Read More

Autoimmun Rev 2016 Nov 1;15(11):1046-1053. Epub 2016 Aug 1.

Renal and Vascular Inflammation Section, Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK. Electronic address:

The anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) are a heterogeneous group of diseases causing inflammation in small blood vessels and linked by the presence of circulating ANCA specific for proteinase 3 (PR3) or myeloperoxidase (MPO). These antigens are present both in the cytoplasmic granules and on the surface of neutrophils, and the effect of ANCA on neutrophil biology has been extensively studied. In contrast, less attention has been paid to the role of monocytes in AAV. Read More

Neurocirugia (Astur) 2016 Nov - Dec;27(6):291-295. Epub 2016 Jul 12.

Servicio de Anatomía Patológica, Hospital Universitario Ramón y Cajal, Madrid, España.

The inflammatory pseudotumour (IPT) is a non-neoplastic entity of unknown origin, and is characterised by a proliferation of connective tissue and a polyclonal inflammatory infiltrate. Central nervous system involvement is uncommon, and usually represents a diagnostic and therapeutic challenge even for the experienced clinician. This reports deals with the case of a 56year-old woman diagnosed with a giant, infiltrating mass centred in the left cavernous sinus, who had a rapid clinical and radiological response to steroid therapy. Read More

Skeletal Radiol 2016 Dec 7;45(12):1735-1740. Epub 2016 Oct 7.

Department of Pathology, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.

Sarcoidosis is a systemic inflammatory disorder characterized by non-caseating granulomas, predominantly involving lung, mediastinal lymph nodes and other organs. Synovium involvement is infrequent, and as far as we know, involvement of a periprosthetic membrane has not been reported in the English literature. Intra-articular diffuse tenosynovial giant cell tumor ("conventional diffuse pigmented villonodular synovitis") is an uncommon, locally aggressive neoplasm with few previous case reports in which it arose in periprosthetic tissues after knee arthroplasty. Read More