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    187 results match your criteria Perioperative DVT Prophylaxis

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    Deep Vein Thrombosis and Pulmonary Embolism Considerations in Orthopedic Surgery.
    Orthop Clin North Am 2017 Apr 27;48(2):127-135. Epub 2017 Jan 27.
    Department of Orthopaedics and Sports Medicine, Detroit Medical Center, University Health Center (UHC), 4201 Saint Antoine Street, 9B, Detroit, MI 48201-2153, USA. Electronic address:
    Patients undergoing orthopedic surgery have an increased risk for deep venous thrombosis (DVT) and pulmonary embolism (PE). These complications are considered detrimental, as they cause major postoperative morbidity and mortality and lead to a substantial health care burden. Because of the high incidence and serious nature of these complications, it is essential for orthopedic surgeons to have a comprehensive knowledge of the risk factors, diagnosis, and treatment of acute DVT and PE. Read More

    Intravenous versus topical tranexamic acid in primary total hip replacement: A meta-analysis.
    Medicine (Baltimore) 2016 Dec;95(50):e5573
    aDalian Medical University, Dalian, Liaoning bDepartment of Orthopedics, Clinical Medical College of Yangzhou University, Subei People's Hospital, Yangzhou, Jiangsu, China.
    Background: As the prevalence of total hip arthroplasty (THA) is increasing, it is usually associated with considerable blood loss. Tranexamic acid (TXA) has been reported to reduce perioperative blood loss in hip joint arthroplasty. But the best route of TXA administration continues to be controversial. Read More

    Increased Lower Extremity Venous Stasis May Contribute to Deep Venous Thrombosis Formation after Microsurgical Breast Reconstruction-An Ultrasonographic Study.
    J Reconstr Microsurg 2017 Mar 28;33(3):173-178. Epub 2016 Nov 28.
    Division of Plastic Surgery, University of Pennsylvania Health Systems, Philadelphia, Pennsylvania.
    Background Despite guideline-compliant prophylaxis, an increased rate of deep venous thrombosis (DVT) formation has been reported following autologous versus implant-based breast reconstruction. We hypothesized that tight abdominal fascia closure might decrease lower extremity venous return and promote venous stasis. Methods An observational crossover study of patients who underwent autologous breast reconstruction using transverse rectus abdominis musculocutaneous/deep inferior epigastric artery perforator flaps was conducted. Read More

    Deep Vein Thrombosis in Indian Cancer Patients Undergoing Major Thoracic and Abdomino-Pelvic Surgery.
    Indian J Surg Oncol 2016 Dec 6;7(4):425-429. Epub 2016 Jun 6.
    Department of Radiodiagnosis, Dr BRA Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, 110029 India.
    The aim of the study was to determine the incidence of postoperative deep vein thrombosis (DVT) in Indian patients undergoing surgery for thoracic and abdomino-pelvic malignancies. A prospective observational study was conducted in a tertiary care cancer centre in North India. Two hundred and fifty consecutive patients who underwent curative surgery for thoracic and abdomino-pelvic malignancies during the period March 2014 to March 2015 were enrolled in the study. Read More

    Living donor renal transplantation in patients with antiphospholipid syndrome: A case report.
    Medicine (Baltimore) 2016 Nov;95(46):e5419
    Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
    Introduction: Antiphospholipid syndrome (APS), autoantibodies directed against phospholipid-binding proteins are associated with cause vascular thrombosis. Patients with APS requiring renal transplantation are at risk of early graft loss due to arterial or venous thrombosis, or thrombotic microangiopathy (TMA). Here, we report 3 cases of successful renal transplantation in patients with APS. Read More

    A Phase II Clinical Trial of the Efficacy and Safety of Short-term (3 days) Enoxaparin for the Prevention of Venous Thromboembolism after Gastric Cancer Surgery.
    Acta Med Okayama 2016 Oct;70(5):401-404
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558,
    Although intermittent pneumatic compression (IPC) has become common as perioperative prophylaxis for venous thromboembolism (VTE) consisting of pulmonary thromboembolism (PE) and deep vein thrombosis (DVT), the prophylactic effect against VTE, especially lethal PE, is not yet satisfactory. Therefore, pharmacologic prophylaxis, such as with enoxaparin, is desirable. While the efficacy and safety of enoxaparin have been proven in several clinical trials, concern about bleeding with longterm (at least 7 days) use have potentially decreased its widespread adoption. Read More

    "Bundle" Practices and Ventilator-Associated Events: Not Enough.
    Infect Control Hosp Epidemiol 2016 Dec 19;37(12):1453-1457. Epub 2016 Sep 19.
    6Division of Critical Care,Department of Anesthesiology,Mayo Clinic,Rochester,Minnesota,United States.
    OBJECTIVE Ventilator-associated events (VAEs) are nosocomial events correlated with length of stay, costs, and mortality. Current ventilator bundle practices target the older definition of ventilator-associated pneumonia and have not been systematically evaluated for their impact on VAEs. DESIGN Retrospective cohort study. Read More

    Silent pulmonary thromboembolism in neurosurgery patients: Report of 2 cases and literature review.
    Medicine (Baltimore) 2016 Aug;95(33):e4589
    Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Background: The requirement of postoperative bedridden and immobilization renders neurosurgical patients with higher risk of deep vein thrombosis (DVT), then more vulnerable for pulmonary thromboembolism (PTE). But silent pulmonary thromboembolism (SPTE) can be the very early stage of any typical form of PTE, its diagnosis and management is therefore critical in neurosurgical departments. However, to date, perioperative SPTE has not been attached with enough attention. Read More

    Timing of Chemical Thromboprophylaxis and Deep Vein Thrombosis in Major Colorectal Surgery: A Randomized Clinical Trial.
    Ann Surg 2016 Oct;264(4):632-9
    *Divisions of Colorectal Surgery, Cedars Sinai Medical Center, Los Angeles, CA †Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA ‡Division of Vascular Surgery, Cedars Sinai Medical Center, Los Angeles, CA §Biostatistics and Bioinformatics Research Center, Cedars Sinai Medical Center, Los Angeles, CA.
    Objective: To identify the optimal timing of perioperative chemical thromboprophylaxis (CTP) and incidence of occult preoperative deep vein thrombosis (OP-DVT) in patients undergoing major colorectal surgery.

    Background: There is limited Level 1 data regarding the optimal timing of CTP in major colorectal surgery and the incidence of OP-DVT remains unclear. Both issues influence the occurrence of venous thromboembolism (VTE) and may impact Medicare reimbursement because of penalties for hospital-acquired conditions. Read More

    Thromboembolic Disease after Cervical Spine Surgery: A Review of 5,405 Surgical Procedures and Matched Cohort Analysis.
    Global Spine J 2016 Aug 26;6(5):465-71. Epub 2015 Nov 26.
    Mayo Clinic, Rochester, Minnesota, United States.
    Study Design: Retrospective matched cohort analysis.

    Objective: The majority of the literature on venous thromboembolism (VTE) after spine surgery is limited to studies of thoracolumbar surgery. Less is known regarding the incidence of VTE and associated risk factors following cervical spine surgery. Read More

    [Substantiation of the system of thrombus formation prevention in treatment of patients with hip joint pathology against the background of arterial insufficiency of the lower extremities].
    Khirurgiia (Mosk) 2016 (5):59-63
    The Kazan State Medical University, The Republican Clinical Hospital, the Republic of Tatarstan Ministry of Health Care, Kazan, Russia.
    Aim: To evaluate effectiveness of electroneurostimulation of the shin muscles as a constituent part of the prevention of TEC in the hip joint pathology at the hospital stage of treatment.

    Material And Methods: With this purpose, there was conducted the extended comparative analysis of the parameters of the blood coagulation system in 27 patients with pathology of the hip joints and the stated concomitant vascular insufficiency. The comparison group comprised 50 patients with uncomplicated pathology of the hip joint who underwent hip joint replacement surgery. Read More

    Intravenous versus topical tranexamic acid in primary total hip replacement: A systemic review and meta-analysis.
    Int J Surg 2016 Aug 2;32:10-8. Epub 2016 Jun 2.
    Traumatology Department, Tianjin Hospital, Tianjin, 300211, PR China.
    Objective: Total hip arthroplasty (THA) is associated with substantial blood loss. Tranexamic acid (TXA) could reduce perioperative blood loss. The optimal administration routine of TXA remains controversial. Read More

    [The Influence of Tourniquet during Total Knee Arthroplasty on Perioperative Blood Loss and Postoperative Complications].
    Masui 2016 Feb;65(2):131-5
    Background: Previous studies have shown that tourniquet (TQ) during total knee arthroplasty (TKA) is associated with nerve injury and deep vein thrombosis. However, it is still not clear whether TQ which is effective in decreasing intraoperative blood loss and creating a bloodless surgical fields, is beneficial in management during and after TKA.

    Methods: We compared intra- and postoperative management of patients undergoing TKA with (Group T, n = 41) and that without a TQ (Group N, n = 40) at Toyama Prefectural Central Hospital. Read More

    Prospective, multicenter study of postoperative deep-vein thrombosis in patients with haemophilia undergoing major orthopaedic surgery.
    Thromb Haemost 2016 Jul 24;116(1):42-9. Epub 2016 Mar 24.
    Tyler W. Buckner, MD, MSc, Division of Hematology, University of Colorado School of Medicine, 13199 E. Montview Blvd, Suite 100, Mailstop F416, Aurora, CO 80045, USA, Tel.: +1 303 724 6182, Fax: +1 303 724 0947, E-mail:
    Perioperative clotting factor replacement is administered to reverse the inherent haemostatic defect in persons with haemophilia (PWH), potentially increasing their risk for developing venous thromboembolism (VTE) postoperatively. It was our objective to determine the prevalence of VTE in PWH undergoing total hip or knee arthroplasty (THA, TKA). Patients with haemophilia A or B who underwent THA or TKA were enrolled in this prospective, multicentre observational cohort study. Read More

    Plasma anti-FXa level as a surrogate marker of the adequacy of thromboprophylaxis in critically ill patients: A systematic review.
    Thromb Res 2016 Mar 4;139:10-6. Epub 2016 Jan 4.
    Tampere University Hospital, Critical Care Medicine Research Group, PO Box 2000, Tampere 33521, Finland.
    Background: Critical care patients are prone to venous thromboembolism (VTE) and, thus, pharmacological thromboprophylaxis is generally advised. Low-molecular weight heparins (LMWHs) have become the drug of choice in ICU patients, since their predictable and reproducible dose response. Monitoring their pharmacological effect is not usually necessary except in special occasions (i. Read More

    Incidence of venous thromboembolism and hemorrhage related safety studies of preoperative anticoagulation therapy in hip fracture patients undergoing surgical treatment: a case-control study.
    BMC Musculoskelet Disord 2016 Feb 12;17:76. Epub 2016 Feb 12.
    Department of Trauma and Orthopedics, People's Hospital, Peking University, South Xizhimen Street No.11, Xicheng District, 100044, Beijing, China.
    Background: Venous thromboembolism is a common postoperative complication following orthopedic surgeries, with morbid and potentially fatal consequences. Perioperative low-molecular-weight heparin (LMWH) therapy can reduce the incidence of venous thromboembolism, but may also increase the risk of bleeding complications. Current literature reflects the need to balance the improved efficacy of early initiating prophylaxis with increased risk of perioperative bleeding. Read More

    Associations between venous thromboembolism onset, D-dimer, and soluble fibrin monomer complex after total knee arthroplasty.
    J Orthop Surg Res 2015 Nov 10;10:172. Epub 2015 Nov 10.
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
    Background: Prevention and early detection of venous thromboembolism (VTE) is important after arthroplasty of the lower limb. The purpose of this study was to investigate the associations between VTE and hemostatic markers after minimally invasive total knee arthroplasty (MIS-TKA).

    Methods: We performed a retrospective study of 50 patients (55 knees) who underwent primary unilateral MIS-TKA with periodic determination of D-dimer and soluble fibrin monomer complex (SFMC) concentrations and with ultrasonography. Read More

    Role of blood transfusion product type and amount in deep vein thrombosis after cardiac surgery.
    Thromb Res 2015 Dec 30;136(6):1204-10. Epub 2015 Oct 30.
    Department of Internal Medicine, Outcomes Research Unit and Vascular Medicine Program, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. Electronic address:
    Background: Postoperative deep vein thrombosis (DVT) is associated with significant morbidity. Even with maximal thromboprophylaxis, postoperative DVT is present in 10% of cardiac surgery patients, and is linked to receiving transfusion. We hypothesized that the incidence of DVT varies with the transfused blood product type, and increases with transfusion dose. Read More

    Safety of perioperative subcutaneous heparin for partial nephrectomy.
    Can J Urol 2015 Oct;22(5):7990-4
    Department of Urology, George Washington University, Washington, DC, USA.
    Introduction: The development of deep venous thrombosis (DVT) or pulmonary embolism (PE) following urologic surgery is a life threatening, but largely preventable complication. Patients undergoing partial nephrectomy are at increased risk for the development of DVT or PE as they often possess multiple risk factors including malignancy, advanced age, and prolonged surgical time. This risk can be significantly reduced by administration of perioperative subcutaneous heparin (SQH), however many surgeons feel this is contraindicated due to potential blood loss and related complications. Read More

    Evaluation of nonpermanent inferior vena cava filter placement in patients with deep venous thrombosis after lower extremity fracture: A single-center retrospective study.
    Phlebology 2016 Sep 6;31(8):564-72. Epub 2015 Aug 6.
    Department of Vascular Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, China.
    Objective: To investigate nonpermanent inferior vena cava (IVC) filter in the prevention of perioperative pulmonary embolism (PE) in patients of lower extremity and/or pelvic bone fracture with deep vein thrombosis (DVT).

    Methods: Lower extremity or pelvic bone fracture patients with lower extremity DVT hospitalized in our hospital from January 2003 to October 2014 were retrospectively analyzed. Data was analyzed for age, gender, position of fracture, position of proximal of thrombosis, indications of placement, complications, retrieval rate, and rate of entrapped filter clot. Read More

    Independent Predictors of 30-Day Perioperative Deep Vein Thrombosis in 1346 Consecutive Patients After Spine Surgery.
    World Neurosurg 2015 Dec 11;84(6):1605-12. Epub 2015 Jul 11.
    Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA. Electronic address:
    Background: Deep vein thrombosis (DVT) is a morbid postsurgical complication. Identifying the perioperative DVT risk profile will improve surgeons' ability to assess patients for surgical candidacy. In addition, these data will help to identify patients who would benefit from DVT chemoprophylaxis. Read More

    Patient, Surgery, and Hospital Related Risk Factors for Surgical Site Infections following Total Hip Arthroplasty.
    ScientificWorldJournal 2015 14;2015:979560. Epub 2015 May 14.
    Department of Orthopaedic Surgery, Division of Adult Reconstruction and Joint Replacement, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA.
    Surgical site infections (SSI) following total hip arthroplasty (THA) have a significantly adverse impact on patient outcomes and pose a great challenge to the treating surgeon. Therefore, timely recognition of those patients at risk for this complication is very important, as it allows for adopting measures to reduce this risk. This review discusses literature reported risk factors for SSI after THA. Read More

    Importance of Postoperative Hydration and Lower Extremity Elevation in Preventing Deep Venous Thrombosis in Full Abdominoplasty: A Report on 450 Consecutive Cases Over a 37-Year Period.
    Aesthet Surg J 2015 Sep 24;35(7):839-41. Epub 2015 May 24.
    Dr Keiter is a plastic surgeon in private practice in Murray, UT. Dr Johns is a Resident and Dr Rockwell is a Professor, Division of Plastic Surgery, University of Utah Health Sciences Center, Salt Lake City, UT.
    Background: Abdominoplasty is a common plastic surgery procedure and has a higher rate of postoperative deep venous thrombosis (DVT) than any other such surgery. DVT prevention remains an important topic in the plastic surgery community. Many surgeons avoid DVT chemoprophylaxis, because they are concerned about the risk of postoperative bleeding. Read More

    Identifying the Bariatric Patient at Risk for Pulmonary Embolism: Prospective Clinical Trial Using Duplex Sonography and Blood Screening.
    Obes Surg 2015 Nov;25(11):2011-7
    Department of Surgery, Protestant Hospital Zweibrücken, Academic Teaching Hospital of Saarland University, Obere Himmelsbergstraße 38, 66482, Zweibrücken, Germany.
    Background: Thromboembolic complications continue to be one of the main reasons for perioperative mortality in bariatric surgery. There is no consensus on which is the safest and most effective thromboprophylaxis. This prospective study aims to evaluate the significance of thrombophilia screening and a venous duplex sonography in bariatric patients. Read More

    Incidence of Postoperative Deep Venous Thrombosis Is Higher among Cardiac and Vascular Surgery Patients as Compared with General Surgery Patients.
    Ann Vasc Surg 2015 28;29(4):661-9. Epub 2015 Feb 28.
    Sectionof Vascular Surgery, Department of Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
    Background: Unlike general surgery patients, most of vascular and cardiac surgery patients receive therapeutic anticoagulation during operations. The purpose of this study was to report the incidence of deep venous thrombosis (DVT) among cardiac and vascular surgery patients, compared with general surgery.

    Methods: The American College of Surgeons National Surgical Quality Improvement Program database was queried for all patients who underwent surgical procedures from 2005 to 2010. Read More

    [Preoperative screening of deep venous thrombosis: cutoff value of D-dimer, age and BMI for further examination of DVT by echo-color-Doppler].
    Masui 2014 Dec;63(12):1350-4
    Background: Pulmonary embolism (PE) is morbid perioperative complication and deep vein thrombosis (DVT) is the most common cause of PE. Echo-color-Doppler examination for DVT is a specific test. But it would not be cost-effective to perform in all preoperative patients. Read More

    The EFFORT trial: Preoperative enoxaparin versus postoperative fondaparinux for thromboprophylaxis in bariatric surgical patients: a randomized double-blind pilot trial.
    Surg Obes Relat Dis 2015 May-Jun;11(3):672-83. Epub 2014 Oct 23.
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Background: Prophylaxis for venous thromboembolism is routinely performed for all patients undergoing bariatric surgery. However, there is disagreement regarding the optimal dosing and duration of anticoagulant therapy. Furthermore, there is little data regarding the incidence of asymptomatic deep venous thrombosis (DVT) in this population. Read More

    Inferior vena cava filters for prevention of venous thromboembolism in obese patients undergoing bariatric surgery: a systematic review.
    Ann Surg 2015 Jan;261(1):35-45
    *Academic Section of Vascular Surgery, Imperial College London, Charing Cross Hospital, Fulham Palace Road, London, United Kingdom †Department of Anaesthetics, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road, London, United Kingdom; and ‡Department of General and Bariatric Surgery, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road, London, United Kingdom.
    Objective: The use of inferior vena cava (IVC) filters for prevention of venous thromboembolism (VTE) in bariatric surgery is a contentious issue. We aim to review the evidence for the use of IVC filters in bariatric surgical patients, describe trends in practice, and discuss challenges in developing evidence-based guidelines.

    Background: The incidence of VTE in modern bariatric procedures with traditional methods of thromboprophylaxis, such as sequential calf compression devices and perioperative low molecular weight heparin, is approximately 2%. Read More

    A case of asymptomatic bilateral massive pulmonary embolism after arthroscopic multiple knee ligament reconstruction.
    Knee Surg Sports Traumatol Arthrosc 2017 Jan 11;25(1):260-262. Epub 2014 Dec 11.
    Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
    Venous thromboembolism, which includes deep venous thrombosis (DVT) and pulmonary embolism (PE), is a serious complication after operations involving the lower extremities, and it can be fatal. However, few reports have described the incidence of PE and its associated risk factors after arthroscopic knee surgery. We present a case of bilateral massive PE of the main pulmonary arteries and DVT detected on multi-detector row computed tomography after arthroscopic multiple knee ligament reconstruction. Read More

    Incidence and risk factors of deep vein thrombosis after liver transplantation.
    Transplant Proc 2014 Dec;46(10):3564-9
    Cedars Sinai Medical Center, Los Angeles, California.
    Background: Deep venous thrombosis (DVT) occurs in 0.1% of persons per year, affecting 15%-40% of general surgical procedures without prophylaxis. Thromboembolic prophylaxis is not commonly used after orthotopic liver transplantation (LT) owing to the risks of bleeding and coagulopathy. Read More

    Blood management of staged bilateral total knee arthroplasty in a single hospitalization period.
    J Orthop Surg Res 2014 Nov 13;9:116. Epub 2014 Nov 13.
    Department of Orthopaedics, West China Hospital, Sichuan University, 37# Wainan Guoxue Road, Chengdu 610041, People's Republic of China.
    Introduction: Few literatures have studied the blood management in patients treated with staged bilateral primary total knee arthroplasty (TKA) in a single hospitalization period. Therefore, this study aims to evaluate the effectiveness and safety of the newly introduced multimodal blood management (MBM) in these patients.

    Materials And Methods: We retrospectively compared the perioperative parameters in 70 cases undergoing staged bilateral primary TKA in a single hospitalization period from 2012-2013 in a single center with two different groups of patients, allocating cases to the group with the newly introduced MBM (Group A, n =33) and controls to the group without the newly introduced MBM (Group B, n =37). Read More

    The efficacy of a thrombin-based hemostatic agent in primary total knee arthroplasty: a meta-analysis.
    J Orthop Surg Res 2014 Oct 15;9:90. Epub 2014 Oct 15.
    Biomechanics Labs of Orthopaedics Institute, Tianjin Hospital, Tianjin, 300050, People's Republic of China.
    Purpose: Total knee arthroplasty (TKA) is a popular procedure in severe osteoarthritis. But perioperative bleeding remains a problem. Floseal® is a mixture of thrombin and bovine gelatin which can benefit a lot on reducing intraoperative and postoperative bleeding. Read More

    Can deep vein thrombosis be predicted after varicose vein operation in women in rural areas?
    Ann Agric Environ Med 2014 ;21(3):601-5
    Department of General, Vascular Surgery and Angiology University of Medical Sciences, Poznań, Poland.
    Introduction: Chronic venous disease is a group of symptoms caused by functional and structural defects of the venous vessels. One of the most common aspects of this disease is the occurrence of varicose veins. There are many ways of prevention and treatment of varicose veins, but in Poland the leading one is still surgery. Read More

    Inferior vena cava filters and postoperative outcomes in patients undergoing bariatric surgery: a meta-analysis.
    Surg Obes Relat Dis 2014 Jul-Aug;10(4):725-33. Epub 2014 Apr 18.
    Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio; Postgraduate and Medical Schools, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru; Unidad de Análisis y Generación de Evidencias en Salud Pública (UNAGESP), Instituto Nacional de Salud, Lima, Peru.
    Background: Pulmonary embolism(PE)accounts for almost 40% of perioperative deaths after bariatric surgery.Placement of prophylactic inferior vena cava(IVC) filter before bariatric surgery to improve outcomes has shown varied results. We performed a meta-analysis to evaluate post- operative outcomes associated with the preoperative placement of IVC filters in these patients. Read More

    [Effects of batroxobin on perioperative blood loss and coagulation in patients with low molecular weight heparin when undergoing the total hip replacement].
    Zhonghua Liu Xing Bing Xue Za Zhi 2014 Jun;35(6):737-40
    Affiliated the First Hospital of Jilin University.
    Objective: To investigate the interactive effects between batroxobin and low molecular weight heparin (LMWH) in reducing peri-operative blood loss and coagulation function in patients who undergone the total hip replacement surgery.

    Methods: 240 ASA I - III patients received 4 000 IU LMWH 12 hours preoperatively before undergoing the total hip replacement operation, were randomly divided into two groups:testing group (Group A, n = 120) and control group (Group B, n = 120) receiving 2 U batroxobin or 50 mg mannitol 10 minutes before incision respectively. Perioperative blood loss, postoperative 24 hours drainage and blood routine test, prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (FIB) were measured respectively. Read More

    [Thromboprophylaxis of venous thromboembolism].
    Nihon Rinsho 2014 Jul;72(7):1303-8
    Recently in Japan, venous thromboembolism (VTE) [deep vein thrombosis (DVT)/pulmonary thromboembolism (PTE)] has increased with the Westernization of eating habits and the aging of society. In the West, prophylactic guidelines have been discussed for many years, and, unfortunately, Japan falls far behind the West in this area. We developed Japanese Guidelines for VTE prophylaxis based on the 6th ACCP guidelines in 2004. Read More

    The incidence of venous thromboembolism (VTE)--after hip arthroscopy.
    Bull Hosp Jt Dis (2013) 2014 ;72(2):154-8
    Purpose: The purpose of this study was to determine the incidence of venous thromboembolism (VTE) after hip arthroscopy.

    Methods: Over the course of 13 months, four surgeons that routinely perform hip arthroscopy participated in a protocol to screen all patients postoperatively for deep venous thrombosis (DVT) using bilateral venous duplex ultrasound at or about the 2 week postoperative time point. All patients were assessed and stratified for VTE risk prior to surgery. Read More

    No impact of endogenous prothrombotic conditions on the risk of central venous line-related thrombotic events in children: results of the KIDCAT study (KIDs with Catheter Associated Thrombosis).
    J Thromb Haemost 2014 Oct 22;12(10):1610-5. Epub 2014 Sep 22.
    Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
    Background And Objective: Central venous lines (CVLs) are the major exogenous risk factor for deep venous thrombosis (DVT) in children. The study objective was to assess whether endogenous prothrombotic conditions contribute to the risk of CVL-related DVT in children.

    Methods: This was a cohort study of consecutive children with heart disease requiring CVLs for perioperative care. Read More

    Venous thromboembolism in high grade glioma among surgical patients: results from a single center over a 10 year period.
    J Neurooncol 2014 Nov 26;120(2):347-52. Epub 2014 Jul 26.
    Department of Neurological Surgery, Northwestern University, McGaw Medical Center, Chicago, IL, USA.
    Patients with high-grade glioma are at elevated risk of venous thromboembolism (VTE). The relationship between VTE and survival in glioma patients remains unclear, as does the optimal protocol for chemoprophylaxis. The purpose of this study was to assessthe incidence of and risk factors associated with VTE in patients with high-grade glioma, and the correlation between VTE and survival in this population. Read More

    Repeated doses of intravenous tranexamic acid are effective and safe at reducing perioperative blood loss in total knee arthroplasty.
    Biosci Trends 2014 Jun;8(3):169-75
    Department of Orthopedic Surgery, Zhongshan Hospital of Fudan University.
    Fibrin sealant (FS) and tranexamic acid (TXA) have been used in total knee arthroplasty (TKA) to minimize perioperative blood loss. The efficacy of FS has been debated, and few studies have looked into the effects of FS and TXA on perioperative coagulability. The current study retrospectively reviewed 100 cases of unilateral primary TKA. Read More

    Predictors and complications of blood transfusion in total hip and knee arthroplasty.
    J Arthroplasty 2014 Sep 24;29(9 Suppl):189-92. Epub 2014 May 24.
    Henry Ford Health System Department of Orthopaedic Surgery, Detroit, Michigan.
    Perioperative patient optimization can minimize the need for blood transfusions in patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA). The purpose of this study was to determine predictors and complications of transfusions. This retrospective review analyzed 1795 patients who underwent primary THA and TKA at our institution between January 2011 and December 2012. Read More

    [Case of trimalleolar ankle fracture managed by placement of a temporary inferior vena cava filter by an anesthesiologist].
    Masui 2014 Jun;63(6):682-5
    A patient with trimalleolar ankle fracture was preoperatively diagnosed with deep vein thrombosis (DVT); after induction of general anesthesia, a temporary inferior vena cava filter (TIVCF) was intraoperatively placed by an anesthesiologist. This contributed to safe anesthesia management. A 65-year-old woman was scheduled to undergo surgery for a trimalleolar ankle fracture sustained in an accidental fall. Read More

    Low molecular weight heparin versus unfractionated heparin for perioperative thromboprophylaxis in patients with cancer.
    Cochrane Database Syst Rev 2014 Jun 26(6):CD009447. Epub 2014 Jun 26.
    Department of Internal Medicine, American University of Beirut, Riad El Solh St, Beirut, Lebanon.
    Background: The choice of the appropriate perioperative thromboprophylaxis in patients with cancer depends on the relative benefits and harms of low molecular weight heparin (LMWH) and unfractionated heparin (UFH).

    Objectives: To update a systematic review of the evidence for the relative efficacy and safety of LMWH and UFH for perioperative thromboprophylaxis in patients with cancer.

    Search Methods: We performed a comprehensive search for trials of anticoagulation in patients with cancer including a February 2013 electronic search of: the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and EMBASE. Read More

    [Prevention of venous thromboembolism and anticoagulant therapy].
    Masui 2014 Mar;63(3):278-86
    Perioperative pulmonary thromboembolism (PTE) occurred in 2.93 per 10,000 cases and mortality of PTE was 14% in Japan according to the surveillance of Japanese Society of Anesthesiologists from 2009 to 2011. Anesthesiologists have to evaluate perioperative venous thromboembolism (VTE) risk carefully and take adequate measures to prevent PTE. Read More

    Use of thrombin-based hemostatic matrix during meningioma resection: a potential risk factor for perioperative thromboembolic events.
    Clin Neurol Neurosurg 2014 Apr 27;119:116-20. Epub 2014 Jan 27.
    Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, USA. Electronic address:
    Objective: Hemostatic agents are widely used in patients undergoing intracranial tumor resection to facilitate local hemostasis. We hypothesized that systemic activation of the clotting cascade after local application of hemostatic agents may result in unintended thromboembolic events, including deep venous thrombosis (DVT) and pulmonary embolism (PE). We performed a retrospective analysis to identify potential associations between hemostatic agent use and DVT/PE. Read More

    Prevalence and countermeasures for venous thromboembolic diseases associated with spinal surgery: a follow-up study of an institutional protocol in 209 patients.
    Spine (Phila Pa 1976) 2014 May;39(10):791-7
    From the Departments of *Orthopaedic Surgery and †Spine Surgery and Medical Engineering, Mie University Graduate School of Medicine, Mie, Japan.
    Study Design: A prospective study of 209 patients undergoing spinal surgery.

    Objective: To determine the incidence of venous thromboembolic diseases, including deep venous thrombosis (DVT) and pulmonary embolism (PE), and to evaluate the effectiveness of an institutional protocol for venous thromboembolic diseases during the spinal surgery perioperative period.

    Summary Of Background Data: Although patients undergoing spinal surgery are at risk of venous thromboembolism (VTE), there are no universally accepted guidelines for VTE prophylaxis. Read More

    Reduction of thromboembolic events in meningioma surgery: a cohort study of 724 consecutive patients.
    PLoS One 2013 14;8(11):e79170. Epub 2013 Nov 14.
    Klinik für Neurochirurgie, UniversitätsSpital Zürich, Zürich, Switzerland.
    Background: Meningiomas are associated with the highest postoperative rate of venous thromboembolic events (VTE) among all intracranial tumors. The aim of this study is to compare two entirely different VTE prophylaxis regimens in 724 consecutive patients undergoing meningioma surgery.

    Methods: Two cohorts at a single institution treated with different regimens to prevent VTE were reviewed retrospectively. Read More

    Does thromboprophylaxis prevent venous thromboembolism after major orthopedic surgery?
    J Bras Pneumol 2013 May-Jun;39(3):280-6
    Ufuk University, Department of Chest Diseases, Ankara, Turkey.
    Objective: Pulmonary embolism (PE) is an important complication of major orthopedic surgery. The aim of this study was to evaluate the incidence of venous thromboembolism (VTE) and factors influencing the development of VTE in patients undergoing major orthopedic surgery in a university hospital.

    Methods: Patients who underwent major orthopedic surgery (hip arthroplasty, knee arthroplasty, or femur fracture repair) between February of 2006 and June of 2012 were retrospectively included in the study. Read More

    Venous thromboembolism prevention in patients undergoing colorectal surgery for cancer.
    ANZ J Surg 2014 Apr 19;84(4):284-8. Epub 2013 Jun 19.
    General Internal Medicine Department, St Vincent's Hospital, Fitzroy, Victoria, Australia.
    Introduction: Patients undergoing surgery for colorectal cancer are at high risk of post-operative venous thromboembolism (VTE). Thromboprophylaxis has been shown to have significant risk reduction, although there remains some controversy surrounding the optimal duration of pharmacological prophylaxis. Our institution does not routinely practise extended prophylaxis. Read More

    Comparison of aspirin plus heparin with heparin alone on asymptomatic perioperative deep vein thrombosis in candidates for elective off-pump coronary artery bypass graft: a randomized clinical trial.
    Cardiol J 2013 ;20(2):139-43
    Background: Symptomatic or asymptomatic deep vein thrombosis (DVT) is a common complication following coronary artery bypass graft (CABG), in which less than 1% of these patients suffer from clinically evident pulmonary embolism (PE). DVT and PE can increase other morbidities of coronary revascularization from short to long period, but no clear consensus still exists regarding proper thromboprophylaxis strategy in the literatures. This study was designed to compare the anti-platelet prophylaxis of aspirin plus heparin with heparin alone on asymptomatic perioperative DVT in patients that are candidates for elective off-pump CABG. Read More

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