Search Our Scientific Publications & Authors

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2021 May 27. Epub 2021 May 27.

Deartment of Anesthesiology, Perioperative Medicine and Intensive Care Masaryk Hospital, J.E. Purkinje University, Usti nad Labem, Czech Republic.

Background: Deep vein thrombosis (DVT) is a serious but preventable complication of critical illness with a reported incidence from 4 to 17%. Anti-Xa activity in critically ill patients achieved with standard dosing of low-molecular-weight heparins (LMWH) is often below the target of 0.2-0. Read More

Medicine (Baltimore) 2021 May;100(18):e25639

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University.

Background: Salvianolate, a common drug for stabilizing heart disease and Angina Pectoris, is considered to be off-label for preventing venous thromboembolism (VTE) or anticoagulation at present. However, many clinical studies have showed that salvianolate can effectively inhibit the deep-vein thrombosis (DVT) incidence, and prevent VTE of perioperative patients in the real world in China.

Objective: This analysis aimed to evaluate the effectiveness and safety of salvianolate in preventing VTE in perioperative patients. Read More

Global Spine J 2021 Apr 20:2192568220979139. Epub 2021 Apr 20.

22683Baylor University Medical Center, Dallas, TX, USA.

Study Design: Systematic literature review.

Objectives: The impact of thromboembolic disease on the morbidity and mortality of patients with acute spinal cord injury is well documented, with rates as high as 67%-100% among untreated patients. The efficacy of mechanical prophylaxis as a stand-alone measure has been questioned, so we sought to determine a safe perioperative window for chemical anticoagulation use after spine surgery. Read More

Pediatr Transplant 2021 Jun 27;25(4):e14017. Epub 2021 Mar 27.

Department of Pediatrics, Section of Pediatric Gastroenterology and Hepatology, University of Chicago, Chicago, IL, USA.

Patients with cirrhotic liver disease are in a state of fluctuating hemostatic balance. Hepatic synthetic dysfunction is commonly complicated by coagulation disorders that constitute an important parameter of most prognostic scores. The dominant feature of this dysfunction is bleeding tendencies, but cirrhotic patients may also exhibit inappropriate clotting and pro-coagulation placing them at risk for thromboembolism. Read More

J Pediatr Surg 2021 Feb 13. Epub 2021 Feb 13.

Department of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, United States; Department of Surgery, University of Tennessee Health Science Center, 910 Madison Ave, Memphis, TN 38163, United States; Division of Pediatric Surgery, LeBonheur Children's Hospital, 848 Adams Ave, Memphis, TN 38103, United States. Electronic address:

Purpose: Cancer is a well-established risk factor for deep venous thrombosis (DVT). We sought to assess the incidence of DVT in pediatric cancer patients undergoing select surgical procedures at our institution and to identify additional factors associated with DVT development.

Methods: We performed a retrospective review of cancer patients who underwent select surgical procedures and developed a DVT within 30 days of their operation from 2000 to 2018 at our institution. Read More

J Gastrointest Surg 2021 02 8;25(2):339-350. Epub 2021 Jan 8.

Department of Surgery, Division of Colorectal Surgery, City of Hope National Medical Center, 1500 E. Duarte Road, Suite MA, Duarte, CA, LP-2230, USA.

Perioperative management entails the multiple substeps in the performance of major abdominal surgery that are considered relevant for an optimal outcome. The PG/CME symposium of the SSAT 2018 provided a set of key talks that the authors subsequently summarized in the respective subsections of this summary article. Highlights topics included oral antibiotics and mechanical bowel prep, surgical site infections, DVT prophylaxis, enhanced recovery after surgery (ERAS), and narcotic-sparing pain management. Read More

Clin Orthop Relat Res 2021 03;479(3):589-600

A. J. Acuña, L. T. Samuel, A. K. Emara, A. F. Kamath, Department of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.

Background: Given the morbidity, mortality, and financial burden associated with venous thromboembolism (VTE) after TKA, orthopaedic providers continually seek to identify risk factors associated with this devastating complication. The association between perioperative transfusion status and VTE risk has not been thoroughly explored, with previous studies evaluating this relationship being limited in both generalizability and power.

Questions/purposes: Therefore, we sought to determine whether perioperative transfusions were associated with an increased risk of (1) pulmonary embolism (PE) or (2) deep vein thrombosis (DVT) after primary TKA in a large, multi-institutional sample. Read More

Clin Appl Thromb Hemost 2020 Jan-Dec;26:1076029620961450

Syosset Hospital, Northwell Health, Syosset, NY, USA.

Two of the more common potential complications after arthroplasty are venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolus (PE), and excess bleeding. Appropriate chemoprophylaxis choices are essential to prevent some of these adverse events and from exacerbating others. Risk stratification to prescribe safe and effective medications in the prevention of postoperative VTE has shown benefit in this regard. Read More

Neurourol Urodyn 2021 01 14;40(1):176-182. Epub 2020 Oct 14.

New York University Langone Health, New York, New York, USA.

Aim: Venous thromboembolism (VTE) rates in vaginal pelvic organ prolapse (POP) repair are low. Our aim is to evaluate specific risk factors for VTE in patients undergoing vaginal POP repair.

Methods: This is a cross-sectional study using the American College of Surgeons NSQIP database. Read More

J Am Acad Dermatol 2021 Feb 9;84(2):425-431. Epub 2020 Oct 9.

Division of Dermatology, University of Kansas Medical Center, Kansas City, Kansas; Advanced Dermatologic Surgery, Overland Park, Kansas.

Background: Direct oral anticoagulants (DOACs), such as apixaban, rivaroxaban, and dabigatran, are increasingly being used to provide prophylaxis and treatment for arterial and venous thromboembolism. Multiple procedural subspecialties have implemented guidelines detailing time frames for perioperative DOAC interruption; however, the impact of perioperative DOAC interruption in patients undergoing dermatologic surgery is currently unknown, and evidence-based guidelines are lacking.

Objective: To assess the 30-day postoperative rate of thrombotic complications (ischemic stroke, transient ischemic attack, systemic embolism, deep vein thrombosis [DVT] and pulmonary embolism) in patients with nonvalvular atrial fibrillation (AF) or a history of DVT who underwent perioperative DOAC interruption during dermatologic surgery. Read More

Asia Pac J Clin Oncol 2020 Oct 2. Epub 2020 Oct 2.

Department of Thoracic Surgery, The Affiliated Brain Hospital of Nanjing Medical University (South Branch, Nanjing Chest Hospital), Nanjing, China.

Objectives: Venous thromboembolism (VTE) is a significant and preventable cause of mortality and morbidity in thoracic surgery. It usually deep venous thromboembolism (DVT) and pulmonary thromboembolism (PE). We conducted this article to perform a systematic review on prophylaxis of perioperative VTE in patients undergoing thoracic surgery especially lung surgery and esophageal surgery and to identify potential areas for future research. Read More

Ann Palliat Med 2020 Sep 3;9(5):2693-2698. Epub 2020 Sep 3.

Department of Operating Room, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Deep vein thrombosis (DVT) poses a considerable perioperative risk in patients who undergo surgical procedures. This study set out to determine the efficacy of self-heating calf sleeves (SHCSs) in preventing postoperative DVT in lung cancer patients undergoing VATS lobectomy.

Methods: This study included 557 participants who underwent video-assisted thoracoscopic surgery (VATS) lobectomy between June, 2018 and June, 2019. Read More

Ann Palliat Med 2020 Sep 7;9(5):2498-2507. Epub 2020 Aug 7.

Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Background: As Asian populations, Chinese have a lower rate of high-risk gene mutations in venous thrombosis. Therefore, individual patient risk assessment, rather than a "blanket policy", is considered the best thromboembolism prophylaxis for Chinese. The purpose of this study was to evaluate the effectiveness and safety of selective thromboembolism prophylaxis compared with conventional thromboembolism prophylaxis by risk stratification with thromboelastography (TEG) after joint arthroplasty in Chinese. Read More

Ann Med Surg (Lond) 2020 Aug 30;56:203-210. Epub 2020 Jun 30.

Clinic for General, Visceral and Thoracic-Surgery, Asklepios Klinik Langen, Academic Teaching Hospital Goethe-Universität Frankfurt, Röntgenstr 20, Langen, 63225, Germany.

Introduction: Recommendations for venous thromboembolism and deep venous thrombosis (DVT) prophylaxis using graduated compression stockings (GCS) is historically based and has been critically examined in current publications. Existing guidelines are inconclusive as to recommend the general use of GCS.Patients/Methods: 24 273 in-patients (general surgery and orthopedic patients) undergoing surgery between 2006 and 2016 were included in a retrospectively analysis from a single center. Read More

J Thromb Thrombolysis 2021 Feb;51(2):397-404

Department of Spinal Surgery, The Third Hospital of Hebei Medical University, 139 Ziqiang Street, Shijiazhuang, 050051, Hebei, China.

To determine the incidence of DVT and to evaluate the risk factors of DVT under LMWH prophylaxis in patients with thoracolumbar fractures caused by high‑energy injuries postoperatively. A total of 534 patients from January 2016 to November 2019 were included in this retrospective study. Medical record data, including demographic data, perioperative variables, and laboratory results, were collected. Read More

Eur Urol 2020 09 19;78(3):360-368. Epub 2020 May 19.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: Direct high-quality evidence is lacking evaluating perioperative pharmacologic prophylaxis (PP) after radical prostatectomy (RP) to prevent venous thromboembolism (VTE) leading to significant practice variation.

Objective: To study the impact of in-hospital PP on symptomatic VTE incidence and adverse events after RP at 30 d, with the secondary objective of evaluating overall VTE in a screening subcohort.

Design, Setting, And Participants: A prospective, phase 4, single-center, randomized trial of men with prostate cancer undergoing open or robotic-assisted laparoscopic RP was conducted (July 2017-November 2018). Read More

J Vasc Surg Venous Lymphat Disord 2020 09 21;8(5):869-881.e2. Epub 2020 Apr 21.

Division of Vascular Surgery, Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pa. Electronic address:

Objective: Perioperative venous thromboembolism (VTE) is generally considered preventable. Whereas the non-vascular surgery literature is rich in providing data about the impact of VTE prophylaxis on VTE outcomes, vascular surgery data are relatively sparse on this topic. This study sought to evaluate the evidence for VTE prophylaxis specifically for the population of vascular surgery patients. Read More

J Surg Res 2020 08 9;252:125-132. Epub 2020 Apr 9.

Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address:

Background: Deep vein thromboses (DVTs) are a significant sequela of surgery and are associated with significant of morbidity and mortality in the United States. Operative emergency general surgery (EGS) cases have been demonstrated to have a greater burden of DVT than other types of surgery.

Materials And Methods: DVT in EGS cases were identified from the National Inpatient Sample-Healthcare Cost and Utilization Project database from 2001 to 2015 Q3 based on ICD-9 code specification. Read More

Asian J Neurosurg 2020 Jan-Mar;15(1):51-58. Epub 2020 Feb 25.

Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, Thailand.

Context: Venous thromboembolism (VTE), including deep-vein thrombosis (DVT) and pulmonary embolism (PE), is the fatal complication following spine surgery and the appropriate perioperative prophylaxis is still debated.

Aims: The aim of this study is to evaluate the incidence of along with risk factors for postoperative VTE in surgically treated extramedullary spinal tumor patients.

Setting And Designs: The study design involves single institute and retrospective cohort study. Read More

J Pediatr Surg 2020 Nov 20;55(11):2387-2392. Epub 2020 Feb 20.

Division of Pediatric Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background/purpose: Children with inflammatory bowel disease (IBD) have increased risk for venous thromboembolism (VTE). We sought to determine incidence and risk factors for postoperative VTE in a multicenter cohort of pediatric patients undergoing colorectal resection for IBD.

Methods: Retrospective review of children ≤18 years who underwent colorectal resection for IBD from 2010 to 2016 was performed at four children's hospitals. Read More

J Hosp Med 2019 Nov 20;14:E1-E6. Epub 2019 Nov 20.

Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.

Background: Patient safety indicators (PSI) were developed for hospitals to screen for healthcare-associated adverse events. PSIs are believed to be preventable and have become a part of major pay-for-performance programs. PSI-12 captures perioperative venous thromboembolism (VTE), which contributes to morbidity and mortality of hospitalized patients. Read More

World J Surg 2020 04;44(4):1302-1308

Department of Surgery, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.

Background: The aim of this study was to compare the perioperative outcomes when using a micropuncture access set (MS) to those when using a conventional puncture set (CS) for implantation of totally implantable venous access device (TAVID).

Methods: A total of 314 patients undergoing chemotherapy for colorectal cancer were included between June 2015 and July 2018. Of these, 123 (39. Read More

J Orthop Surg Res 2019 Dec 11;14(1):430. Epub 2019 Dec 11.

Department of Orthopaedic, The Fifth Affiliated Hospital Of Sun Yat-Sen University, No. 52, Meihua East Road, Zhuhai, 519000, Guangdong, China.

Background: Tranexamic acid (TXA) is widely used to reduce blood loss and transfusion rates in total hip arthroplasty(THA). Thromboelastography, which can monitor coagulation changes from clotting to fibrinolysis dynamically. In this study, thromboelastography was used to assess the dynamic changes in the coagulation of patients who underwent THA with the administration of TXA. Read More

Surgeon 2020 Aug 1;18(4):219-225. Epub 2019 Dec 1.

Basingstoke and North Hampshire Hospital, Aldermaston Rd, Basingstoke, Hampshire, United Kingdom.

Introduction: Current NICE Guidelines state that all patients undergoing total hip and knee arthroplasty should be given both mechanical and chemical prophylaxis. At our institution, a targeted thromboprophylaxis policy has been in place since October 1999. The aim of this study was to calculate our venous thromboembolism rates and compare these to published rates in the literature. Read More

J Knee Surg 2021 Jun 15;34(7):749-754. Epub 2019 Nov 15.

Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

Tranexamic acid (TXA) has been shown to reduce blood loss and postoperative transfusions in total knee arthroplasty (TKA). There is no consensus on the ideal dosing regimen in the literature, although there is a growing body of literature stating there is little benefit to additional doses. Our study compared one versus two doses of TXA in primary TKA and its effect on postoperative transfusion rate. Read More

Surg Endosc 2020 09 15;34(9):4177-4184. Epub 2019 Oct 15.

Division of Bariatric, Foregut and Advanced Gastrointestinal Surgery, Department of Surgery, Stony Brook University Medical Center, Stony Brook, USA.

Introduction: Management of patients on chronic anticoagulation (AC) in bariatric surgery may present a challenge, as there is a delicate balance between risks of bleeding and thrombotic events, such as deep vein thrombosis (DVT) and pulmonary embolism (PE). The purpose of this study was to evaluate and compare rates of bleeding, thrombotic events, and outcomes of patients on preoperative AC during bariatric surgery.

Methods: The MBSAQIP data sets for 2015 and 2016 was used to identify all patients undergoing adjustable gastric banding (AGB), sleeve gastrectomy (SG), and Roux-en-Y gastric bypass (RYGB). Read More

Ann Gastroenterol Surg 2019 Sep 22;3(5):534-543. Epub 2019 Jul 22.

Department of Gastroenterological Surgery Graduate School of Medicine Osaka University Suita Osaka Japan.

Aim: To investigate the frequency and risk factors of perioperative, symptomatic venous thromboembolism (VTE) after gastroenterological surgery.

Methods: We assessed the frequency of and risk factors for VTE after eight gastroenterological procedures (total 516 217 cases including, gastrectomy, total gastrectomy, hepatectomy, esophagectomy, right hemicolectomy, low anterior resection, pancreaticoduodenectomy, and acute pan-peritonitis surgery) based on data from the National Clinical Database. Data collected between 2011 and 2013 (382 124 cases) were used as a test set, and data from 2014 (134 093 cases) were used as a validation set. Read More

J Arthroplasty 2020 01 17;35(1):45-51.e3. Epub 2019 Aug 17.

Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL.

Background: Tranexamic acid (TXA) administration to reduce postoperative blood loss and transfusion is a well-established practice for total knee arthroplasty (TKA) and total hip arthroplasty (THA). However, clinical concerns remain about the safety of TXA in patients with a history of a prothrombotic condition. We sought to determine the risk of complications between high-risk and low-risk TKA and THA patients receiving TXA. Read More

BJU Int 2019 12 10;124(6):935-944. Epub 2019 Oct 10.

Department of Urology, Lister Hospital, Stevenage, UK.

Objectives: Venous thromboembolism (VTE), consisting of both pulmonary embolism (PE) and deep vein thromboses (DVT), remains a well-recognised complication of major urological cancer surgery. Several international guidelines recommend extended thromboprophylaxis (ETP) with LMWH, whereby the period of delivery is extended to the post-discharge period, where the majority of VTE occurs. In this literature review we investigate whether ETP should be indicated for all patients undergoing major urological cancer surgery, as well procedure specific data that may influence a clinician's decision. Read More

J Bone Joint Surg Am 2019 Aug;101(16):1495-1504

Southern California Hip Institute, North Hollywood, California.

Background: The aims of this study were to describe a novel minimally invasive, interlocking periacetabular osteotomy (PAO) for the treatment of hip dysplasia that was developed at our institution and to report on its safety, complications, and early clinical outcomes.

Methods: This was a prospective longitudinal study of the first 200 consecutive hips that underwent the CU (University of Colorado) PAO, an interlocking osteotomy combining the benefits of the Birmingham interlocking pelvic osteotomy (BIPO) and the Ganz PAO. The technique provides direct visualization of the sciatic nerve during the ischial osteotomy and allows for immediate weight-bearing postoperatively. Read More