2,355 results match your criteria Perilymph Fistula


Development and performance of a biomimetic artificial perilymph for in vitro testing of medical devices.

J Neural Eng 2018 Nov 28. Epub 2018 Nov 28.

Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, 2052, AUSTRALIA.

Objective: Cochlear implants interface with the fluid in the cochlea called perilymph. The volume of this fluid present in human and animal model cochlea is prohibitively low for isolation for in vitro studies. Thus, there is a need for an artificial perilymph that reflects the complexity of this fluid in terms of competitive protein adsorption. Read More

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November 2018

Magnetic resonance-based volumetric measurement of the endolymphatic space in patients with Meniere's disease and other endolymphatic hydrops-related diseases.

Auris Nasus Larynx 2018 Nov 29. Epub 2018 Nov 29.

Department of Otorhinolaryngology Head and Neck Surgery, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara, Japan.

Objective: To employ magnetic resonance imaging (MRI) to measure the volume of the inner ear endolymphatic space (ELS) in patients with acute low-tone sensorineural hearing loss (ALHL), sudden deafness (SD), cochlear Meniere's disease (cMD), and unilateral MD (uMD) compared with control subjects (CS) with chronic rhinosinusitis.

Methods: Forty-one patients with ALHL, 82 with SD, 48 with cMD, 72 with uMD, and 47 CS participated in the study. With the exception of all uMD patients, none of the subjects had vertigo. Read More

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November 2018
3 Reads

Dexamethasone and Dexamethasone Phosphate Entry into Perilymph Compared for Middle Ear Applications in Guinea Pigs.

Audiol Neurootol 2018 29;23(4):245-257. Epub 2018 Nov 29.

Otonomy, Inc., San Diego, California, USA.

Dexamethasone phosphate is widely used for intratympanic therapy in humans. We assessed the pharmacokinetics of dexamethasone entry into perilymph when administered as a dexamethasone phosphate solution or as a micronized dexamethasone suspension, with and without inclusion of poloxamer gel in the medium. After a 1-h application to guinea pigs, 10 independent samples of perilymph were collected from the lateral semicircular canal of each animal, allowing entry at the round window and stapes to be independently assessed. Read More

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November 2018

Gentamicin delivery to the inner ear: Does endolymphatic hydrops matter?

PLoS One 2018 15;13(11):e0207467. Epub 2018 Nov 15.

Department of Otorhinolaryngology, S.João Hospital Centre, Porto, Portugal.

Introduction: Middle ear application of gentamicin is a common medical treatment for uncontrolled Ménière's disease. The objective of the study was to evaluate the impact of endolymphatic hydrops on inner ear delivery.

Methods: Perilymph gentamicin concentrations and correlation with endolymphatic hydrops in an animal model were assessed. Read More

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November 2018
8 Reads

Evolution of Endolymph Secretion and Endolymphatic Potential Generation in the Vertebrate Inner Ear.

Brain Behav Evol 2018 9;92(1-2):1-31. Epub 2018 Nov 9.

Research Center Neurosensory Science, Carl von Ossietzky University Oldenburg, Oldenburg,

The ear of extant vertebrates reflects multiple independent evolutionary trajectories. Examples include the middle ear or the unique specializations of the mammalian cochlea. Another striking difference between vertebrate inner ears concerns the differences in the magnitude of the endolymphatic potential. Read More

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November 2018
3 Reads

Design of a resilient ring for middle ear's chamber stapes prosthesis.

Comput Methods Biomech Biomed Engin 2018 Nov 9:1-9. Epub 2018 Nov 9.

b Institute of Micromechanics and Photonics , Warsaw University of Technology , Warsaw , Poland.

This paper presents the process of designing a new elastic element replacing a membrane in the chamber stapes prosthesis (ChSP). The results of the study are volume displacement characteristics obtained for the prosthesis and physiological stapes. Simulation tests on a 3D CAD model have confirmed that a properly designed ring can stimulate perilymph with the same or greater efficacy as the physiological stapes footplate placed on the elastic annular ligament. Read More

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November 2018

Response of the inner ear to lipopolysaccharide introduced directly into scala media.

Hear Res 2018 Dec 17;370:105-112. Epub 2018 Oct 17.

The University of Sydney, Meniere's Research Laboratory, Australia.

In an attempt to develop an animal model of immune mediated Meniere's disease, we have injected lipopolysaccharide (LPS) directly into scala media of guinea pigs and monitored functional and morphological changes over a period of 6 weeks. Depending on the concentration of LPS, changes ranged from moderate-to-severe hearing loss and endolymphatic hydrops with minimal cellular infiltrate or fibrosis, to dense cellular infiltration that filled the scalae. Interestingly, higher concentrations of LPS not only induced severe cellular infiltration, hydrops, and hearing loss, but also a substantial enlargement of the endolymphatic duct and sac. Read More

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December 2018
6 Reads

Successful hearing improvement with direct acoustic stimulation in a patient with schizophrenia.

J Laryngol Otol 2018 Oct 28;132(10):946-948. Epub 2018 Sep 28.

Department of Otorhinolaryngology and Maxillofacial Surgery,Maribor University Clinical Center,Koper,Slovenia.

Objective: A direct acoustic cochlear implant provides its power directly to the inner ear by vibrating the perilymph via a conventional stapes prosthesis. Our experience with a patient with severe mixed hearing loss due to otosclerosis is described.Case reportThe patient, a 47-year-old male, had a pre-operative speech recognition score of 10 per cent and had been treated for many years for schizophrenia, both of which made him a poor candidate for a direct acoustic stimulation device. Read More

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October 2018
3 Reads

A comparison of systemic and local dexamethasone administration: From perilymph/cochlea concentration to cochlear distribution.

Hear Res 2018 Dec 7;370:1-10. Epub 2018 Sep 7.

Department of Otorhinolaryngology, Head and Neck Surgery, People's Hospital, Peking University, Beijing, PR China. Electronic address:

Different types of inner ear diseases can damage different cochlear subsites by different mechanisms. Steroids administered by different methods are commonly used for treating inner ear diseases. There is reason to believe that dexamethasone (Dex) may reach cochlear subsite targets via different pathways after administration by different methods: Intratympanic (IT), postaural (PA), and intraperitoneal (IP). Read More

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December 2018
2 Reads

A Polymer-Based Extended Release System for Stable, Long-term Intracochlear Drug Delivery.

Otol Neurotol 2018 Oct;39(9):1195-1202

O-Ray Pharma, Inc.

Objective: Investigate a new polymer-based drug coating suitability for safe intracochlear delivery and ability to maintain long-term physiologically active levels of the corticosteroid fluticasone propionate.

Study Design: In vitro dissolution study to evaluate release profiles of polymer-coated drug particles and in vivo studies using a guinea pig model to measure perilymph drug concentrations at specific time points after implantation with polymer-coated drug particles and evaluate their effect on hearing function.

Methods: Polymer-coated fluticasone propionate (FP) particles were surgically implanted in guinea pigs through the round window membrane into the cochlear scala tympani. Read More

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October 2018

Magnetic Resonance Imaging of Ménière's Disease After Intravenous Administration of Gadolinium.

Ann Otol Rhinol Laryngol 2018 Nov 29;127(11):777-782. Epub 2018 Aug 29.

1 Department of Otolaryngology-Head and Neck Surgery, Fudan University, Shanghai, China.

Objectives: A three-dimensional (3D) inversion-recovery (IR) sequence with real reconstruction (3D-real IR) sequence 4 hours after intravenous (IV) gadolinium injection has been used to visualize the endolymphatic hydrops (ELH) in Ménière's disease (MD). This study was designed to investigate the ELH characteristics in clinically diagnosed definite MD and to explore the pathology of MD with magnetic resonance imaging (MRI).

Methods: One hundred fifty-four patients with definite MD were included in this study. Read More

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November 2018
5 Reads

Recent and Frequent Vertigo Attacks Produce Negative Findings on Furosemide-Loading Vestibular Evoked Myogenic Potential Testing in Meniere's Disease.

Front Neurol 2018 3;9:636. Epub 2018 Aug 3.

Department of Otolaryngology, Kindai University, Osakasayama, Japan.

The peak-to-peak amplitude of the p13-n23 wave in cervical vestibular evoked myogenic potential can increase after furosemide administration in patients with Meniere's disease [furosemide-loading VEMP (FVEMP) testing]. The examination is used to test for the presence of endolymphatic hydrops; we investigated factors that may influence the results. Forty-two subjects (23 males and 19 females, aged 24-70 years) with unilateral definite Meniere's disease who underwent FVEMP testing were retrospectively studied. Read More

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August 2018
9 Reads

Novel Computed Tomography Findings Suggestive of Perilymph Gusher.

Otol Neurotol 2018 Sep;39(8):1066-1069

Department of Otolaryngology.

Objectives: Perilymphatic gusher (PLG) is an uncommon complication of stapedectomy and cochlear implant placement. Computerized tomography (CT) may reveal congenital dysplasia responsible for PLG but may also be (incorrectly) interpreted as normal. The aim of this study was to review CT findings in patients with PLG reported to have normal temporal bones. Read More

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September 2018
2 Reads

Visualization of the Membranous Labyrinth and Nerve Fiber Pathways in Human and Animal Inner Ears Using MicroCT Imaging.

Front Neurosci 2018 31;12:501. Epub 2018 Jul 31.

VetImaging, VetCore Facility for Research, University of Veterinary Medicine, Vienna, Austria.

Design and implantation of bionic implants for restoring impaired hair cell function relies on accurate knowledge about the microanatomy and nerve fiber pathways of the human inner ear and its variation. Non-destructive isotropic imaging of soft tissues of the inner ear with lab-based microscopic X-ray computed tomography (microCT) offers high resolution but requires contrast enhancement using compounds with high X-ray attenuation. We evaluated different contrast enhancement techniques in mice, cat, and human temporal bones to differentially visualize the membranous labyrinth, sensory epithelia, and their innervating nerves together with the facial nerve and middle ear. Read More

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July 2018
7 Reads

Adjuvant agents enhance round window membrane permeability to dexamethasone and modulate basal to apical cochlear gradients.

Eur J Pharm Sci 2019 Jan 11;126:69-81. Epub 2018 Aug 11.

Otolaryngology, Department of Surgery, University of Melbourne, East Melbourne 3002, Australia; Royal Victorian Eye and Ear Hospital, East Melbourne 3002, Australia.

Glucocorticoids have direct anti-inflammatory, anti-oxidant and anti-apoptotic effects on cochlear hair cells. Cochlear glucocorticoid therapy has gained particular attention for its ability to enhance the protection of residual hearing following hearing preservation cochlear implantation. Local drug delivery methods achieve high drug concentrations within the inner ear fluids but are reliant upon diffusion across the round window membrane. Read More

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January 2019
7 Reads
3.350 Impact Factor

Rapid analysis of neomycin in cochlear perilymph of guinea pigs using disposable SPE cartridges and high performance liquid chromatography-tandem mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Sep 26;1093-1094:52-59. Epub 2018 Jun 26.

Department of Otolaryngology, Head and Neck Surgery, The Institute of Otolaryngology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, China; Key Laboratory of Hearing Impairment Science (Chinese PLA Medical School), Ministry of Education, China. Electronic address:

Irreversible hearing loss induced by aminoglycoside in human through local or systemic administration route negatively impacts quality of life. The aim of this work was to develop and validate an analytical method suitable for the detection and quantification of neomycin in cochlear perilymph of guinea pig after local application. The SupelMIP SPE column was used for the pre-treatment of matrix. Read More

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September 2018
4 Reads
2.730 Impact Factor

Validation of metabolomics analysis of human perilymph fluid using liquid chromatography-mass spectroscopy.

Hear Res 2018 Sep 22;367:129-136. Epub 2018 May 22.

UMR 1253, iBrain. Université de Tours, Inserm, Tours, France. Electronic address:

Although there is some data from animal studies, the metabolome of inner ear fluid in humans remains unknown. Characterization of the metabolome of the perilymph would allow for better understanding of its role in auditory function and for identification of biomarkers that might allow prediction of response to therapeutics. There is a major technical challenge due to the small sample of perilymph fluid available for analysis (sub-microliter). Read More

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September 2018

The proteome of perilymph in patients with vestibular schwannoma. A possibility to identify biomarkers for tumor associated hearing loss?

PLoS One 2018 1;13(6):e0198442. Epub 2018 Jun 1.

Department of Surgical Sciences, Otorhinolaryngology and Head and Neck Surgery, Uppsala University, Uppsala, Sweden.

Background: Due to the surrounding bone, the human inner ear is relatively inaccessible and difficult to reach for cellular and molecular analyses. However, these types of investigations are needed to better understand the etiology, pathophysiology and progression of several inner ear disorders. Moreover, the fluid from the inner ear cannot be sampled for micro-chemical analyses from healthy individuals in vivo. Read More

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December 2018

Mechanisms of Hearing Loss in a Guinea Pig Model of Superior Semicircular Canal Dehiscence.

Neural Plast 2018 24;2018:1258341. Epub 2018 Apr 24.

ENT Institute and Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, Fudan University, Shanghai, China.

Defective acoustic transmission in the cochlea is closely related with various auditory and vestibular symptoms. Among them, semicircular canal dehiscence (SCD) with a defective semicircular bone is typical. Currently, the pathogenesis of SCD is usually explained by the third window hypothesis; however, this hypothesis fails to explain the variability in the symptoms and signs experienced by superior SCD (SSCD) patients. Read More

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April 2018
8 Reads

Preparation, characterization and application research of a sustained dexamethasone releasing electrode coating for cochlear implantation.

Mater Sci Eng C Mater Biol Appl 2018 Sep 16;90:16-26. Epub 2018 Apr 16.

Department of Otolaryngology Head & Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. Electronic address:

Cochlear inflammatory response after cochlear implantation (CI) is an important mechanism for implantation trauma and hearing loss. The hearing loss was also caused by damage to auditory hair cells (HCs), whereas ion homeostasis within the cochlea can ensure survival of HCs. In our study, pure hyaluronic acid (HA) was crosslinked with 1, 4-butanediol diglycidyl ether (BDDE) and the successful preparation of the cross-linked hydrogel (CHA) was confirmed by rheological characteristics and FTIR spectra. Read More

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September 2018
2 Reads

Diagnosis and Treatment of Perilymphatic Fistula.

Adv Otorhinolaryngol 2018 6;81:133-145. Epub 2018 Apr 6.

Perilymphatic fistula (PLF) is defined as an abnormal communication between the fluid (perilymph)-filled space of the inner ear and the air-filled space of the middle ear and mastoid, or cranial spaces. PLF is located in the round or oval window, fractured bony labyrinth, microfissures, anomalous footplate, and can occur after head trauma or barotrauma, chronic inflammation, or in otic capsule dehiscence. This clinical entity was initially proposed more than a century ago, yet it has remained a topic of controversy for more than 50 years. Read More

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October 2018
66 Reads

Feasibility of microRNA profiling in human inner ear perilymph.

Neuroreport 2018 Aug;29(11):894-901

Departments of Otolaryngology Head and Neck Surgery.

Hearing loss is common and caused by a wide range of molecular and cellular pathologies. Current diagnosis of hearing loss depends on a combination of physiologic testing, patient history, and in some cases genetic testing. Currently, no biopsy or equivalent procedure exists to diagnose inner ear disorders. Read More

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August 2018
1 Read

Osmotic stabilization prevents cochlear synaptopathy after blast trauma.

Proc Natl Acad Sci U S A 2018 05 7;115(21):E4853-E4860. Epub 2018 May 7.

Caruso Department of Otolaryngology-Head and Neck Surgery, University of Southern California, Los Angeles, CA 90033

Traumatic noise causes hearing loss by damaging sensory hair cells and their auditory synapses. There are no treatments. Here, we investigated mice exposed to a blast wave approximating a roadside bomb. Read More

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Hybrid Ear Cubes for local controlled dexamethasone delivery to the inner ear.

Eur J Pharm Sci 2019 Jan 1;126:23-32. Epub 2018 May 1.

Univ. Lille, Inserm, CHU Lille, U1008, F-59000 Lille, France. Electronic address:

A new type of miniaturized implants for local controlled drug delivery to the inner ear is proposed: Hybrid Ear Cubes. They are composed of two main parts: (i) a cylinder, which is placed into a tiny hole (<0.4 mm) drilled into (or close to) the oval (or round) window, and (ii) a cuboid, which is placed into the middle ear. Read More

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January 2019

Optimized phospholipid-based nanoparticles for inner ear drug delivery and therapy.

Biomaterials 2018 Jul 16;171:133-143. Epub 2018 Apr 16.

Department of Medical Lifescience, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Catholic Photomedicine Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

To develop efficient carriers for inner ear drug delivery, we prepared four kinds of phospholipid-based nanoparticles: neutral, anionic, cationic, and cationic-PEG (polyethyleneglycol) particles. PEG was used to maintain long-term particle circulation in the perilymph, avoiding non-specific binding of particles to proteins. All four nanoparticles were about 200 nm in diameter, and their zeta potentials were -4. Read More

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July 2018
2 Reads

Pneumolabyrinth, intracochlear and vestibular fluid loss after cochlear implantation.

Auris Nasus Larynx 2018 Oct 19;45(5):1116-1120. Epub 2018 Apr 19.

Department of Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, Japan; Department of Hearing Implant Sciences , Shinshu University School of Medicine , Matsumoto , Japan.

The present case was a 38-year-old male who presented with progressive hearing loss, resulting in profound bilateral hearing loss. He had a past history of childhood medulloblastoma, which was treated with posterior fossa craniotomy and radiotherapy. A ventriculoperitoneal (VP) shunt was put in place to manage the hydrocephalus. Read More

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October 2018
2 Reads

MicroRNA profile of human endo-/perilymph.

J Neurol 2018 Oct 17;265(Suppl 1):26-28. Epub 2018 Apr 17.

Department of Neurology, German Center for Vertigo and Balance Disorders, DSGZ, Klinikum Grosshadern, Ludwig Maximilians University, Feodor-Lynen-Str. 19, 81377, Munich, Germany.

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October 2018
2 Reads

A fluorescence-based imaging approach to pharmacokinetic analysis of intracochlear drug delivery.

Hear Res 2018 Oct 5;368:41-48. Epub 2018 Apr 5.

Biomedical Engineering Center, Charles Stark Draper Laboratory, 555 Technology Square, Cambridge MA 02139, United States. Electronic address:

Advances in microelectromechanical systems (MEMS) technologies are enhancing the development of intracochlear delivery devices for the treatment of hearing loss with emerging pharmacological therapies. Direct intracochlear delivery addresses the limitations of systemic and intratympanic delivery. However, optimization of delivery parameters for these devices requires pharmacokinetic assessment of the spatiotemporal drug distribution inside the cochlea. Read More

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October 2018
1 Read

Permeation Enhancers for Intratympanically-applied Drugs Studied Using Fluorescent Dexamethasone as a Marker.

Otol Neurotol 2018 Jun;39(5):639-647

Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri.

Hypothesis: Entry of locally applied drugs into the inner ear can be enhanced by chemical manipulations.

Background: Perilymph drug concentrations achieved by intratympanic applications are well below the applied concentration due to limited entry through the round window (RW) membrane and stapes. Chemical manipulations to increase entry permeability could increase the effectiveness of drug therapy with local applications. Read More

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A comparison of cochlear distribution and glucocorticoid receptor activation in local and systemic dexamethasone drug delivery regimes.

Hear Res 2018 Oct 20;368:75-85. Epub 2018 Mar 20.

Otolaryngology, Department of Surgery, University of Melbourne, East Melbourne, 3002, Australia; Royal Victorian Eye and Ear Hospital, East Melbourne, 3002, Australia.

Local and systemically delivered glucocorticoids are commonly administered to protect the cochlea against damage associated with a variety of insults. There is reason to believe that dexamethasone administered by these routes may arrive at cochlear target sites via different pathways. Clinically, there is a lack of clarity as to which route is more effective in any specific circumstance. Read More

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October 2018
1 Read
2.970 Impact Factor

Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications.

Hear Res 2018 Oct 11;368:28-40. Epub 2018 Mar 11.

Department of Otorhinolaryngology, Head and Neck Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Local drug delivery to the ear has gained wide clinical acceptance, with the choice of drug and application protocol in humans largely empirically-derived. Here, we review the pharmacokinetics underlying local therapy of the ear using the drugs commonly used in clinical practice as examples. Based on molecular properties and perilymph measurements interpreted through computer simulations we now better understand the principles underlying entry and distribution of these and other drugs in the ear. Read More

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October 2018
5 Reads

Is oval window transport a royal gate for nanoparticle delivery to vestibule in the inner ear?

Eur J Pharm Sci 2019 Jan 28;126:11-22. Epub 2018 Feb 28.

School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China; Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Pharmaceutical University, Guangzhou, China; Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, China. Electronic address:

Drug delivery to the inner ear by nanomedicine strategies has emerged as an effective therapeutic approach for the management of inner ear diseases including hearing and balance disorders. It is well accepted that substance enters the perilymph from the middle ear through the round window membrane (RWM), but the passage through the oval window (OW) has long been neglected. Up to now, researchers still know little about the pathway via which nanoparticles (NPs) enter the inner ear or how they reach the inner ear following local applications. Read More

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January 2019
4 Reads

One-Stage Complete Resection of Cholesteatoma With Labyrinthine Fistula: Hearing Changes and Clinical Outcomes.

Ann Otol Rhinol Laryngol 2018 Apr 6;127(4):241-248. Epub 2018 Feb 6.

1 Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea.

Objectives: To evaluate long-term hearing changes and surgical outcomes for middle ear cholesteatoma with labyrinthine fistula following complete surgical removal of the cholesteatoma matrix.

Methods: Consecutive samples of 43 patients who underwent 1-stage complete resection of the cholesteatoma matrix overlying a labyrinthine fistula were obtained. Immediate and long-term hearing changes were analyzed in association with fistula size. Read More

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April 2018
24 Reads

Understanding the translocation mechanism of PLGA nanoparticles across round window membrane into the inner ear: a guideline for inner ear drug delivery based on nanomedicine.

Int J Nanomedicine 2018 22;13:479-492. Epub 2018 Jan 22.

School of Pharmacy.

Background: The round window membrane (RWM) functions as the primary biological barrier for therapeutic agents in the inner ear via local application. Previous studies on inner ear nano-drug delivery systems mostly focused on their pharmacokinetics and distribution in the inner ear, but seldom on the interaction with the RWM. Clarifying the transport mechanism of nanoparticulate carriers across RWM will shed more light on the optimum design of nano-drug delivery systems intended for meeting demands for their clinical application. Read More

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April 2018
1 Read

Comparison of enhancement of the vestibular perilymph between gadoterate meglumine and gadobutrol at 3-Tesla in Meniere's disease.

Diagn Interv Imaging 2018 May 15;99(5):271-277. Epub 2018 Feb 15.

Department of Neuroradiology and MRI, Grenoble-Alpes University Hospital, SFR RMN Neurosciences, 38043 cedex 9 Grenoble, France.

Purpose: To compare the degree of enhancement of the perilymph between two macrocyclic gadolinium-based contrast agents (gadobutrol and gadoterate meglumine) in patients with Meniere's disease at 3-T magnetic resonance imaging (MRI).

Materials And Methods: The MRI examinations of 20 patients with Meniere's disease obtained 4hours after a single intravenous dose of macrocyclic gadolinium-based contrast agents were retrospectively compared. Ten patients (median age: 58. Read More

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May 2018
2 Reads

The diagnostic performance of a novel ELISA for human CTP (Cochlin-tomoprotein) to detect perilymph leakage.

PLoS One 2018 29;13(1):e0191498. Epub 2018 Jan 29.

Department of Otorhinolaryngology, Saitama Medical University, Saitama, Japan.

Perilymphatic fistula is defined as an abnormal communication between the perilymph-filled space and the middle ear, or cranial spaces. The manifestations include a broad spectrum of neuro-otological symptoms such as hearing loss, vertigo/dizziness, disequilibrium, aural fullness, tinnitus, and cognitive dysfunction. By sealing the fistula, perilymphatic fistula is a surgically correctable disease. Read More

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March 2018
6 Reads
3.230 Impact Factor

DFNB1 Non-syndromic Hearing Impairment: Diversity of Mutations and Associated Phenotypes.

Front Mol Neurosci 2017 22;10:428. Epub 2017 Dec 22.

Servicio de Genética, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.

The inner ear is a very complex sensory organ whose development and function depend on finely balanced interactions among diverse cell types. The many different kinds of inner ear supporting cells play the essential roles of providing physical and physiological support to sensory hair cells and of maintaining cochlear homeostasis. Appropriately enough, the gene most commonly mutated among subjects with hereditary hearing impairment (HI), , encodes the connexin-26 (Cx26) gap-junction channel protein that underlies both intercellular communication among supporting cells and homeostasis of the cochlear fluids, endolymph and perilymph. Read More

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December 2017

Inner ear test battery in guinea pig models - a review.

Authors:
Yi-Ho Young

Acta Otolaryngol 2018 Jun 8;138(6):519-529. Epub 2018 Jan 8.

a Department of Otolaryngology , National Taiwan University Hospital , Taipei , Taiwan.

Objective: This study reviewed the development of the inner ear test battery comprising auditory brainstem response (ABR), and caloric, ocular vestibular-evoked myogenic potential (oVEMP), and cervical vestibular-evoked myogenic potential (cVEMP) tests in guinea pig models at our laboratory over the last 20 years. Detailed description of the methodology for testing the small animals is also included.

Methods: Inner ear disorders, i. Read More

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June 2018
7 Reads

Recent surgical options for vestibular vertigo.

GMS Curr Top Otorhinolaryngol Head Neck Surg 2017 18;16:Doc01. Epub 2017 Dec 18.

Department of Otolaryngology, Head & Neck Surgery, Ruhr-University of Bochum at the St. Elisabeth Hospital of Bochum, Germany.

Vertigo is not a well-defined disease but a symptom that can occur in heterogeneous entities diagnosed and treated mainly by otolaryngologists, neurologists, internal medicine, and primary care physicians. Most vertigo syndromes have a good prognosis and management is predominantly conservative, whereas the need for surgical therapy is rare, but for a subset of patients often the only remaining option. In this paper, we describe and discuss different surgical therapy options for hydropic inner ear diseases, Menière's disease, dehiscence syndromes, perilymph fistulas, and benign paroxysmal positional vertigo. Read More

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December 2017
3 Reads

Communication pathways to and from the inner ear and their contributions to drug delivery.

Hear Res 2018 May 19;362:25-37. Epub 2017 Dec 19.

Department of Otolaryngology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO, USA.

The environment of the inner ear is highly regulated in a manner that some solutes are permitted to enter while others are excluded or transported out. Drug therapies targeting the sensory and supporting cells of the auditory and vestibular systems require the agent to gain entry to the fluid spaces of the inner ear, perilymph or endolymph, which surround the sensory organs. Access to the inner ear fluids from the vasculature is limited by the blood-labyrinth barriers, which include the blood-perilymph and blood-strial barriers. Read More

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May 2018
3 Reads

Reference intervals for the evoked tympanic membrane displacement measurement: a non-invasive measure of intracranial pressure.

Physiol Meas 2018 01 31;39(1):015008. Epub 2018 Jan 31.

Neurological Physics, Department of Medical Physics, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.

Objective: Evoked tympanic membrane displacement (TMD) is a non-invasive technique for assessing intracranial pressure (ICP). The aim of this study was to define reference intervals (RIs) in the healthy population.

Approach: Measurements were made in 154 healthy adults. Read More

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January 2018
7 Reads

Mannitol and the blood-labyrinth barrier.

J Otolaryngol Head Neck Surg 2017 Dec 11;46(1):66. Epub 2017 Dec 11.

Department of Otolaryngology - Head & Neck Surgery, University of Manitoba, GB421 - 820 Sherbrook Street, Winnipeg, MB, R3A 1R9, Canada.

Background: Characterization of the blood labyrinth barrier (BLB) is extremely important to determine whether the BLB can be manipulated pharmacologically. However, experiments to investigate the BLB are technically difficult to perform. In this report, we demonstrated a unique method of controlling the BLB, and established the pharmacokinetics of gentamicin in perilymph, cerebrospinal fluid (CSF) and blood with and without mannitol. Read More

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December 2017
4 Reads

High Resolution Three-Dimensional Delayed Contrast MRI Detects Endolymphatic Hydrops in Patients With Vertigo and Vestibular Schwannoma.

Otol Neurotol 2018 01;39(1):e39-e44

Department of Otolaryngology-Head and Neck Surgery.

Objective: Advances in high resolution magnetic resonance imaging (MRI) have enabled the detection of endolymphatic hydrops (EH), a pathological ballooning of the endolymphatic fluid system, known to be associated with Menière's disease. When a patient has a known diagnosis of vestibular schwannoma and develops recurrent episodic vertigo spells, many surgeons recommend surgical intervention, attributing the vestibular symptoms to the vestibular schwannoma. The aim of this study is to evaluate the clinical outcome in patients with vestibular schwannoma and EH, treated medically, for recurrent spells of vertigo. Read More

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January 2018
8 Reads

Heat Shock Proteins in Human Perilymph: Implications for Cochlear Implantation.

Otol Neurotol 2018 01;39(1):37-44

Department of Otolaryngology, Hannover Medical School.

Objective: Biomarkers reflecting the etiology and pathophysiology of inner ear diseases are limited. Evaluation of proteins in the perilymph may improve our understanding of inner ear disease. Heat shock proteins (HSP) belong to a superfamily of stress proteins and promote refolding of denatured proteins. Read More

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January 2018
22 Reads

Transcanal endoscopic ear surgery for perilymphatic fistula after electric acoustic stimulation.

Auris Nasus Larynx 2018 Jun 6;45(3):657-660. Epub 2017 Nov 6.

Department of Otolaryngology - Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Kita-Ku, Okayama 700-8558, Japan.

Transcanal endoscopic ear surgery (TEES) will become a very useful therapeutic option. A perilymphatic fistula (PLF) is defined as sudden sensorineural hearing loss and/or vertigo caused by leakage of the perilymph through a fistula from the oval window and/or round window. We report a case of PLF after electric acoustic stimulation (EAS), a kind of cochlear implant, successfully treated by TEES. Read More

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June 2018
9 Reads

Comparing perilymph proteomes across species.

Laryngoscope 2018 01 2;128(1):E47-E52. Epub 2017 Nov 2.

Graduate School of Biomedical Engineering, University of New South Wales Sydney, Sydney, New South Wales, Australia.

Objectives/hypothesis: Biological components of perilymph affect the electrical performance of cochlear implants. Understanding the perilymph composition of common animal models will improve the understanding of this impact and improve the interpretation of results from animal studies and how it relates to humans.

Study Design: Analysis and comparison of the proteomes of human, guinea pig, and cat perilymph. Read More

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January 2018
9 Reads

Comorbidities confounding the outcomes of surgery for third window syndrome: Outlier analysis.

Laryngoscope Investig Otolaryngol 2017 10 22;2(5):225-253. Epub 2017 Aug 22.

Siker Medical Imaging and Intervention Portland Oregon.

Objective: Patients with third window syndrome and superior semicircular canal dehiscence (SSCD) symptoms whose surgical outcomes placed them as outliers were systematically studied to determine comorbidities that were responsible for their poor outcomes due to these confounding factors.

Study Design: Observational analytic case-control study in a tertiary referral center.

Methods: Twelve adult patients with clinical SSCD syndrome underwent surgical management and had outcomes that did not resolve all of their subjective symptoms. Read More

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October 2017
19 Reads