487 results match your criteria Perilymph Fistula


[Traumatic perilymphatic fistula. Report of a pediatric case].

Arch Argent Pediatr 2021 04;119(2):e167-e170

División de Otorrinolaringología, Hospital General de Niños Pedro De Elizalde. Buenos Aires, Argentina.

Traumatic perilymphatic fistula is an unusual pathology. Generally caused by pencils, swabs, hair buckles, and matches. Among the most frequent symptoms, patients can present hearing loss and vertigo. Read More

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Congenital Membranous Stapes Footplate Producing Episodic Pressure-Induced Perilymphatic Fistula Symptoms.

Front Neurol 2020 10;11:585747. Epub 2020 Nov 10.

Department of Otorhinolaryngology, Saitama Medical University, Saitama, Japan.

Recent third window syndrome studies have revealed that the intact bony labyrinth and differences in the stiffness of the oval and round windows are essential for proper cochlear and vestibular function. Herein we report a patient with a congenital dehiscence of the right stapes footplate. This dehiscence caused long-standing episodic pressure-induced vertigo (Hennebert sign). Read More

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November 2020

Traumatic Stapediovestibular Dislocation With Intact Stapes: Report and Review.

Ear Nose Throat J 2020 Oct 23:145561320968925. Epub 2020 Oct 23.

Department of Otolaryngology-Head and Neck Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Stapediovestibular dislocation is a rare disorder as a result of traumatic injury to the structures in the middle ear. We described a case of a 60-year-old female with stapediovestibular dislocation with associated perilymph fistula. She presented with symptoms including hearing loss, vertigo, and tinnitus after a penetrating injury by an ear pick. Read More

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October 2020

Perilymphatic Fistula: A Review of Classification, Etiology, Diagnosis, and Treatment.

Front Neurol 2020 15;11:1046. Epub 2020 Sep 15.

Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, United States.

A perilymphatic fistula (PLF) is an abnormal communication between the perilymph-filled inner ear and the middle ear cavity, mastoid, or intracranial cavity. A PLF most commonly forms when the integrity of the oval or round window is compromised, and it may be trauma-induced or may occur with no known cause (idiopathic). Controversy regarding the diagnosis of idiopathic PLF has persisted for decades, and the presenting symptoms may be vague. Read More

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September 2020

[The diagnostic value of cochlin-tomoprotein in perilymphatic fistula].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Sep;34(9):857-861

Perilymphatic fistula(PLF) is defined as an abnormal communication between the fluid(perilymph) -filled space of the inner ear and the air-filled space of the middle ear and mastoid, or cranial spaces. At present the diagnostic criteria for perilymphatic fistula is the fistula hole confirmed by the microscope and endoscope between the middle ear and inner ear, the hole is located in the round or oval window, fractured bony labyrinth, microfissures, anomalous footplate, and can occur after head trauma or barotrauma, chronic inflammation, or in otic capsule dehiscence. Recently, the cochlin-tomoprotein(CTP) detected from the middle ear. Read More

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September 2020

Membranous or Hypermobile Stapes Footplate: A New Anatomic Site Resulting in Third Window Syndrome.

Front Neurol 2020 20;11:871. Epub 2020 Aug 20.

Clinical Audiologist, Department of Otolaryngology-Head and Neck Surgery and Communication Sciences, University of Louisville, Louisville, KY, United States.

To describe a potentially underappreciated pathology for post-traumatic persistent intractable dizziness and third window syndrome as well as the methods to diagnose and surgically manage this disorder. Observational analytic case studies review at a tertiary care medical center. Patients suffering persistent dizziness following head trauma and demonstrating Tullio phenomena or Hennebert signs are included. Read More

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Perilymphatic Fistula: Consideration Based on MRI and Surgery.

Otol Neurotol 2021 Jan;42(1):e107-e109

Department of Head and Neck Surgery, Lariboisière University Hospital, Paris, France.

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January 2021

Trauma-induced vestibular dysfunction: Possible functional repair under α1-antitrypsin-rich conditions.

Cell Immunol 2020 10 12;356:104150. Epub 2020 Jun 12.

Department of Clinical Biochemistry & Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Transient vestibular organ deafferentation, such that is caused by traumatic tissue injury, is presently addressed by corticosteroid therapy. However, restoration of neurophysiological properties is rarely achieved. Here, it was hypothesized that the tissue-protective attributes of α1-antityrpsin (AAT) may promote restoration of neuronal function. Read More

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October 2020

Imaging Analysis for Cholesteatoma Extension to the Perilymphatic Space in Labyrinth Fistulae.

Laryngoscope 2021 04 17;131(4):E1301-E1307. Epub 2020 Aug 17.

Department of Otorhinolaryngology, The Jikei University School of Medicine, Tokyo, Japan.

Objectives/hypothesis: Disturbed perilymph behind a labyrinth fistula can lead to hearing deterioration; thus, delicate manipulation is required during surgery for cholesteatomatous fistulae with matrix extension to the perilymphatic space (EPS). However, it remains challenging to identify the EPS preoperatively. This study aimed to evaluate the diagnostic value of computed tomography (CT) for preoperative prediction of the EPS of cholesteatomatous fistulae. Read More

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[Does sealing the oval window in addition to the round window bring an advantage in reserve therapy of acute idiopathic deafness?]

HNO 2021 Jan;69(1):31-41

Klinik für Hals‑, Nasen- und Ohrenheilkunde, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Deutschland.

Background: Following sudden unilateral deafness or severe sensorineural hearing loss, patients with unsuccessful intravenous steroid therapy can be treated with explorative tympanotomy with sealing of the round (RW) and/or oval window (OW), due to suspected rupture of the RW with perilymph fistula (PLF) or a fissula ante fenestram (FAF). This study investigated whether additional sealing of the oval window (RW+OW) achieved an improved hearing benefit as compared to sealing of the round window only (RW) .

Methods: This retrospective study investigated 54 patients with acute profound hearing loss who underwent tympanoscopy. Read More

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January 2021

Oval window perilymph fistula in child with recurrent meningitis and unilateral hearing loss.

BMJ Case Rep 2020 Jul 26;13(7). Epub 2020 Jul 26.

Department of Paediatric Otolaryngology, Cochlear Implants, Great Ormond Street Hospital for Children NHS Trust, London, UK.

A 2-year-old boy presented to Ears, Nose and Throat (ENT) surgeons with unilateral hearing loss. Following a prodrome of upper respiratory tract infection (URTI), he developed two episodes of pneumococcal meningitis in quick succession. This case demonstrates an unusual cause of perilymph fistula diagnosed on imaging and confirmed surgically. Read More

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Exploratory tympanotomy in sudden sensorineural hearing loss for the identification of a perilymphatic fistula - retrospective analysis and review of the literature.

J Laryngol Otol 2020 Jun;134(6):501-508

Department of Otolaryngology, Hannover Medical School, Hannover, Germany.

Objective: The diagnostic value of exploratory tympanotomy in sudden sensorineural hearing loss remains controversial. This study and review were performed to identify the incidence of perilymphatic fistula in patients with sudden sensorineural hearing loss. The effectiveness of tympanotomy for sealing of the cochlear windows in cases with perilymphatic fistula was evaluated. Read More

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Use of topical fluorescein in the diagnosis and localization of perilymphatic fistula.

Am J Otolaryngol 2020 Sep - Oct;41(5):102488. Epub 2020 Apr 11.

Bezmialem Vakif University, Faculty of Medicine, Department of Otorhinolaryngology, Fatih, Istanbul, Turkey.

Objective: The purpose of this video presentation is to demonstrate the effect of intraoperative dilute topical fluorescein in perilympatic fistula diagnosis and localization.

Materials And Methods: Explorative tympanotomy was performed for the diagnosis, localization and repair of the fistula in the patient who had a pre-diagnosis of perilymphatic fistula. Topical fluorescein was applied intraoperatively to localize the defect. Read More

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November 2020

Vestibular drop attack: A potential origin from perilymphatic fistula?

Med Hypotheses 2020 Mar 6;140:109668. Epub 2020 Mar 6.

Organi di Senso Department University, Sapienza University of Rome, Viale del Policlinico, 151, 00161 Rome, Italy. Electronic address:

Vestibular drop attacks are defined as a sudden fall to the ground without an obvious loss of consciousness lasting a few minutes or seconds. They are usually associated with Meniere's Disease during Tumarkin's phase. This hypothesis was produced in consideration of the case of a young girl affected by perilymphatic fistula and her Drop attacks. Read More

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CT and MRI for the diagnosis of perilymphatic fistula: a study of 17 surgically confirmed patients.

Eur Arch Otorhinolaryngol 2020 Apr 10;277(4):1045-1051. Epub 2020 Feb 10.

Service de Radiologie 1, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Background: We evaluated the usefulness of CT and MRI for the diagnosis of perilymphatic fistula (PLF) of the round (RW) and/or oval (OW) windows, with surgery as gold standard.

Methods: We retrospectively enrolled 17 patients who presented a surgically confirmed PLF of the round (RW) or oval (OW) windows. All patients were imaged by CT + MRI (T2W SSFP without contrast) prior to surgery (= gold standard). Read More

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Third Window Syndrome: Surgical Management of Cochlea-Facial Nerve Dehiscence.

Front Neurol 2019 13;10:1281. Epub 2019 Dec 13.

Department of Neurosurgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States.

This communication is the first assessment of outcomes after surgical repair of cochlea-facial nerve dehiscence (CFD) in a series of patients. Pre- and post-operative quantitative measurement of validated survey instruments, symptoms, diagnostic findings and anonymous video descriptions of symptoms in a cohort of 16 patients with CFD and third window syndrome (TWS) symptoms were systematically studied. Observational analytic case-control study. Read More

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December 2019

Total endoscopic stapes surgery: Systematic review and pooled analysis of audiological outcomes.

Laryngoscope 2020 05 30;130(5):1282-1286. Epub 2019 Sep 30.

Department of Otolaryngology, St. George's Hospital, London, United Kingdom.

Objective: This study evaluates the current evidence base for total endoscopic stapes surgery, specifically to establish current efficacy and safety of the technique within clinical practice.

Data Sources: A systematic review of the literature on endoscopic stapes surgery was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis checklist. A comprehensive search of PubMed, Embase, and the Cochrane Central Register of Controlled Trials database for relevant publications for all available dates with appropriate Medical Subject Headings search criteria in January 2018. Read More

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Perilymphatic Fistulas and Superior Semi-Circular Canal Dehiscence Syndrome.

Adv Otorhinolaryngol 2019 15;82:93-100. Epub 2019 Jan 15.

Perilymphatic fistulas (PLF) and superior semi-circular canal dehiscence syndrome (SCDS) are 2 conditions that can present with sound and/or pressure-induced vertigo. PLF should be suspected in cases of trauma or surgery, while a spontaneous PLF is a diagnosis of exclusion. Research is ongoing to identify an ideal biomarker for perilymph. Read More

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December 2019

Surgical Outcomes on Hearing and Vestibular Symptoms in Barotraumatic Perilymphatic Fistula.

Otol Neurotol 2019 04;40(4):e356-e363

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul.

Objective: To analyze surgical results on hearing and vestibular symptoms in patients with barotraumatic perilymphatic fistula (PLF) according to diagnostic criteria.

Methods: A total of 39 patients (41 ears) who underwent surgery on suspicion of barotraumatic PLF from January 2005 to December 2017 were included. Pure tone audiometry and videonystagmography (VNG) recording for spontaneous nystagmus and positional tests were performed preoperatively and postoperatively at 1 week and 1 month. Read More

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Vestibule-Middle Ear Dehiscence Tested With Perilymph-Specific Protein Cochlin-Tomoprotein (CTP) Detection Test.

Front Neurol 2019 30;10:47. Epub 2019 Jan 30.

Department of Otolaryngology, Kindai University Faculty of Medicine, Osaka, Japan.

An 8-year-old boy was referred to the ENT department for further evaluation of right-sided conductive hearing loss. A small cyst anterior to the oval window and fixation of the stapes footplate were observed during an exploratory tympanotomy. The concentration of a perilymph-specific protein, cochlin-tomoprotein (CTP), in the middle ear lavage fluid was measured with an ELISA-based CTP detection kit. Read More

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January 2019

Positive perilymph fistula test with semicircular canal dehiscence from cholesteatoma.

CMAJ 2019 01;191(4):E104

Department of Radiology (Hsieh) and Otolaryngology (Wang), Ditmanson Medical Foundation Chia-yi Christian Hospital, Chia-yi City, Taiwan; Department of Otolaryngology (Wu), National Taiwan University Hospital, Taipei, Taiwan

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January 2019

Diagnosis and Treatment of Perilymphatic Fistula.

Adv Otorhinolaryngol 2018 6;81:133-145. Epub 2018 Apr 6.

Perilymphatic fistula (PLF) is defined as an abnormal communication between the fluid (perilymph)-filled space of the inner ear and the air-filled space of the middle ear and mastoid, or cranial spaces. PLF is located in the round or oval window, fractured bony labyrinth, microfissures, anomalous footplate, and can occur after head trauma or barotrauma, chronic inflammation, or in otic capsule dehiscence. This clinical entity was initially proposed more than a century ago, yet it has remained a topic of controversy for more than 50 years. Read More

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October 2018

One-Stage Complete Resection of Cholesteatoma With Labyrinthine Fistula: Hearing Changes and Clinical Outcomes.

Ann Otol Rhinol Laryngol 2018 Apr 6;127(4):241-248. Epub 2018 Feb 6.

1 Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea.

Objectives: To evaluate long-term hearing changes and surgical outcomes for middle ear cholesteatoma with labyrinthine fistula following complete surgical removal of the cholesteatoma matrix.

Methods: Consecutive samples of 43 patients who underwent 1-stage complete resection of the cholesteatoma matrix overlying a labyrinthine fistula were obtained. Immediate and long-term hearing changes were analyzed in association with fistula size. Read More

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The diagnostic performance of a novel ELISA for human CTP (Cochlin-tomoprotein) to detect perilymph leakage.

PLoS One 2018 29;13(1):e0191498. Epub 2018 Jan 29.

Department of Otorhinolaryngology, Saitama Medical University, Saitama, Japan.

Perilymphatic fistula is defined as an abnormal communication between the perilymph-filled space and the middle ear, or cranial spaces. The manifestations include a broad spectrum of neuro-otological symptoms such as hearing loss, vertigo/dizziness, disequilibrium, aural fullness, tinnitus, and cognitive dysfunction. By sealing the fistula, perilymphatic fistula is a surgically correctable disease. Read More

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Inner ear test battery in guinea pig models - a review.

Authors:
Yi-Ho Young

Acta Otolaryngol 2018 Jun 8;138(6):519-529. Epub 2018 Jan 8.

a Department of Otolaryngology , National Taiwan University Hospital , Taipei , Taiwan.

Objective: This study reviewed the development of the inner ear test battery comprising auditory brainstem response (ABR), and caloric, ocular vestibular-evoked myogenic potential (oVEMP), and cervical vestibular-evoked myogenic potential (cVEMP) tests in guinea pig models at our laboratory over the last 20 years. Detailed description of the methodology for testing the small animals is also included.

Methods: Inner ear disorders, i. Read More

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Transcanal endoscopic ear surgery for perilymphatic fistula after electric acoustic stimulation.

Auris Nasus Larynx 2018 Jun 6;45(3):657-660. Epub 2017 Nov 6.

Department of Otolaryngology - Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Kita-Ku, Okayama 700-8558, Japan.

Transcanal endoscopic ear surgery (TEES) will become a very useful therapeutic option. A perilymphatic fistula (PLF) is defined as sudden sensorineural hearing loss and/or vertigo caused by leakage of the perilymph through a fistula from the oval window and/or round window. We report a case of PLF after electric acoustic stimulation (EAS), a kind of cochlear implant, successfully treated by TEES. Read More

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Comorbidities confounding the outcomes of surgery for third window syndrome: Outlier analysis.

Laryngoscope Investig Otolaryngol 2017 10 22;2(5):225-253. Epub 2017 Aug 22.

Siker Medical Imaging and Intervention Portland Oregon.

Objective: Patients with third window syndrome and superior semicircular canal dehiscence (SSCD) symptoms whose surgical outcomes placed them as outliers were systematically studied to determine comorbidities that were responsible for their poor outcomes due to these confounding factors.

Study Design: Observational analytic case-control study in a tertiary referral center.

Methods: Twelve adult patients with clinical SSCD syndrome underwent surgical management and had outcomes that did not resolve all of their subjective symptoms. Read More

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October 2017

Resolution of Persistent Post-Stapedotomy Vertigo With Migraine Prophylactic Medication.

Otol Neurotol 2017 12;38(10):1500-1504

*Division of Neurotology and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery †Department of Biomedical Engineering, University of California, Irvine, California.

Objective: To describe persistent post-stapedotomy vertigo (PSV) and its treatment using migraine prophylaxis.

Patients: A retrospective review of all patients with persistent PSV spanning 10 years at a tertiary academic hospital was performed. Patients who experienced persistent vertigo for a minimum of 3 months after surgery were included. Read More

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December 2017