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Hum Pathol 2022 04 25;122:25-31. Epub 2022 Jan 25.

Yale University, School of Medicine, New Haven, CT 06510, USA. Electronic address:

As the demand for organ transplantation increases, utilization of liver allografts of donation after cardiac death (DCD) is becoming increasingly necessary. Although the clinical outcomes of DCD allografts have been well described, the histologic features are not well characterized. Liver biopsies (n = 131) from age-matched DCD (n = 60) and donation after brain death (DBD; n = 71) recipients with hepatitis C virus were compared. Read More

Vet Parasitol 2020 Sep 16;285:109215. Epub 2020 Aug 16.

Department of Veterinary Medicine, University of Bari, Valenzano, Italy; Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran. Electronic address:

Feline lungworms such as Aerulostrongylus abstrusus and Troglostrongylus brevior are snail-borne pathogens causing respiratory disease in domestic cats. Paratenic hosts such as rodents and reptiles have also been implicated in the epidemiology of these parasites. Although A. Read More

N Z Vet J 2021 Jan 2;69(1):58-64. Epub 2020 Sep 2.

EpiLab, School of Veterinary Science, Massey University, Palmerston North, New Zealand.

In October 2019, a free-range egg laying flock suffering an outbreak of spotty liver disease was investigated. Eight 32-week-old hens were examined post-mortem. Five of the eight hens had sparse, focal, gross hepatic lesions typical of spotty liver disease. Read More

J Comp Pathol 2019 Jul 12;170:34-45. Epub 2019 Jun 12.

Laboratório de Patologia Comparada de Animais Selvagens, Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Avenida Professor Orlando Marques de Paiva 87, São Paulo, Brazil.

The lowland tapir (Tapirus terrestris) is the largest land mammal in South America. The species faces steady population decline due to poaching, habitat loss and fragmentation, road-kill, pesticide pollution, competition with domestic livestock and fires, among other threats. The lowland tapir is currently listed as vulnerable to extinction. Read More

Sci Rep 2017 07 19;7(1):5921. Epub 2017 Jul 19.

Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA.

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor (AhR). Male C57BL/6 mice orally gavaged with TCDD (0.01-30 µg/kg) every 4 days for 28 days exhibited bile duct proliferation and pericholangitis. Read More

Scand J Gastroenterol 2017 Mar 16;52(3):321-327. Epub 2016 Nov 16.

a Clinic of Gastroenterology, Department of Medicine , Helsinki University Hospital , Helsinki , Finland.

Objective: In autoimmune hepatitis, data on the prognostic value of baseline liver biopsy and the sequential histology is controversial. Our aim was to evaluate the prognostic value of clinical variables and biopsy at the time of diagnosis and during the disease course.

Materials And Methods: All 98 patients in our hospital during 1995-2012 were included. Read More

Hepatobiliary Surg Nutr 2015 Feb;4(1):E1-7

1 Cirugía Hepato-pancreática y Biliar, Departamento de Cirugía y Traumatología, Universidad de La Frontera, Temuco, Chile ; 2 Cirugía Hepato-pancreática y Biliar, Departamento de Cirugía, Clínica Alemana de Temuco, Temuco, Chile ; 3 Departamento de Imágenes Clínica Alemana de Temuco, Facultad de Medicina Clínica Alemana-Universidad del Desarrollo, Temuco, Chile ; 4 Departamento de Patología, Universidad de La Frontera, Temuco, Chile ; 5 Laboratorio de Inmunoparasitología Molecular CEGIN, Departamento de Ciencias Preclínicas, Universidad de La Frontera, Temuco, Chile ; 6 Departamento de Medicina Interna, Universidad de La Frontera, Temuco, Chile ; 7 Servicio de Gastroenterología, Clínica Alemana de Temuco, Temuco, Chile.

Human fascioliasis is a rare zoonosis in Chile. Clinically it presents with a highly polymorphous group of symptoms that evolve in two periods. The first, acute or a result of hepatic invasion, lasts 2 weeks to 4 months and is characterized essentially by pain in the right hypochondrium and/or epigastrium, continuous fever and painful hepatomegaly. Read More

Am J Surg Pathol 2014 Dec;38(12):1636-43

*Department of Pathology, Massachusetts General Hospital and Harvard School of Medicine, Boston, MA †Carolinas Pathology Group, Carolinas Medical Center, Charlotte, NC ‡Infectious Disease Associates of Kansas City, Kansas City, MO.

Syphilis, a sexually transmitted infection caused by the spirochete Treponema pallidum, has seen a resurgence since 2001, particularly in men who have sex with men. Syphilis can affect the liver during the secondary stage as syphilitic hepatitis and during the tertiary stage as gummas. We describe 3 cases of syphilis in human immunodeficiency virus-positive homosexual men that presented as hepatic mass lesions clinically suspected of being malignant tumors. Read More

Int J Clin Exp Pathol 2013 15;6(4):771-9. Epub 2013 Mar 15.

Institute of Pathology, University Hospital, Erlangen, Germany.

Hepatic angiomyolipoma (AML) is rare. Based on its wide histomorphological range, several distinctive histological variants have been delineated. However, hepatic AML displaying predominantly or exclusively inflammatory pattern closely mimicking inflammatory pseudotumor (IPT) is exceptionally rare with only 7 cases reported so far. Read More

Environ Toxicol Pharmacol 2011 Jul 4;32(1):82-101. Epub 2011 Apr 4.

Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.

The purpose of this study was to investigate the potential acute and 28-day repeated oral toxicities of besifloxacin (BAF) in Wistar albino rats. In oral acute and repeated dose study, BAF was administered to both sex of rats, at dose levels of 0, 300, 600, 900 mg/kg/day and 0, 100, 200, 500 mg/kg/day, respectively. In the acute study, total white blood cell (WBC) (male, 43. Read More

Vet Parasitol 2011 Dec 17;182(2-4):181-92. Epub 2011 May 17.

Marine Zoology Unit, Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia, PO Box 22085, 46071 Valencia, Spain.

Sparidae are economically important fishes to both, fisheries and aquaculture in the Mediterranean. Species diversification is an important strategy for the development of Mediterranean aquaculture. One of the species recently introduced is the sharpsnout seabream Diplodus puntazzo (Walbaum, 1792). Read More

Curr Ther Res Clin Exp 2010 Apr;71(2):118-28

Department of Biostatistics, Faculty of Medicine, Trakya University, Edirne, Turkey.

Background: Hydatid disease is a worldwide health problem. Treatment is surgical or percutaneous, using scolicidal agents. Caustic sclerosing cholangitis might develop after the contact of scolicidal agents with the biliary ducts. Read More

Inflamm Bowel Dis 2010 Sep;16(9):1598-619

Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

Diseases involving the hepatopancreatobiliary (HPB) system are frequently encountered in patients with inflammatory bowel disease (IBD). Hepatobiliary manifestations constitute some of the most common extraintestinal manifestations of IBD. They appear to occur with similar frequency in patients with Crohn's disease or ulcerative colitis. Read More

Sci Total Environ 2010 Apr 18;408(9):2136-45. Epub 2010 Jan 18.

Department of Environmental Sciences G. Sarfatti, University of Siena, Siena, Italy.

The aim of the present study was to evaluate the environmental threat to benthic species from chemical weapons dumped in the southern Adriatic Sea. An ecotoxicological approach using chemical analysis and biological responses was applied, in two sentinel species: the Blackbelly rosefish Helicolenus dactylopterus and European conger Conger conger. Specimen were collected in a stretch of sea, where had been dumped war materials and from a reference site free of ordnance. Read More

HPB (Oxford) 2006 ;8(2):153-5

Department of Surgery, Hospital General de Granollers, Barcelona, Spain.

Idiopathic fibrosing pancreatitis has been associated with Sjögren's syndrome, primary biliary cirrhosis and primary sclerosing cholangitis. This condition frequently develops in childhood and youth, and has also been related to ulcerative colitis and pericholangitis. Pancreatic complications have been rarely described as systemic complications of ulcerative colitis. Read More

Folia Parasitol (Praha) 2007 Jun;54(2):109-16

Israel Oceanographic and Limnological Research Ltd., National Center for Mariculture, Eilat 88112, Israel.

Two species of Coccomyxa Léger et Hesse, 1907, one of the least studied myxosporean genera, are reported from shallow coastal waters in the Gulf of Eilat, Red Sea, Israel. A new species, Coccomyxajirilomi sp. n. Read More

Am J Pathol 2007 Aug 28;171(2):525-36. Epub 2007 Jun 28.

Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University Graz, Austria.

Xenobiotics and drugs may lead to cholangiopathies and biliary fibrosis, but the underlying mechanisms are largely unknown. Therefore, we aimed to characterize the cause and consequences of hepatobiliary injury and biliary fibrosis in 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-fed mice as a novel model of xenobiotic-induced cholangiopathy. Liver morphology, markers of inflammation, cell proliferation, fibrosis, bile formation, biliary porphyrin secretion, and hepatobiliary transporter expression were studied longitudinally in DDC- and control diet-fed Swiss albino mice. Read More

J Comp Pathol 2006 Feb-Apr;134(2-3):134-42. Epub 2006 Mar 9.

Forschungs- und Technologiezentrum Westküste, Christian-Albrechts-Universität zu Kiel, 25761 Buesum, Germany.

A study of 37 by-caught harbour porpoises from Icelandic and Norwegian waters showed that most were in good or moderate nutritional condition and none was severely emaciated. Mild infection with lungworms (Halocercus invaginatus, Pseudalius inflexus, Torynurus convolutus) was found in 84% of the Icelandic and 91% of the Norwegian animals, usually associated with bronchopneumonia which was rarely severe. Most (91%) of the animals had parasites in the stomach and intestine (Anisakis simplex, Contracaecum osculatum, Pholeter gastrophilus), and Campula oblonga was present in the liver and pancreas of 88 and 21%, respectively. Read More

Pathol Res Pract 2005 ;201(8-9):565-72

Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

Inflammatory disorders of the biliary tract present difficult diagnostic problems in liver needle biopsies. The aim of this study was to perform a detailed histologic analysis of liver biopsies from patients with biliary tract disorders, classify them by pattern of inflammation, and determine the accuracy of the histologic classification by clinical follow-up. Percutaneous liver needle biopsies from the surgical pathology files of UmassMemorial Healthcare (UMMHC) from 2000 to 2003 with a diagnosis suggesting a biliary tract process (n = 32) and four biopsies from cases with systemic non-biliary tract disorders were analyzed for multiple histologic features and classified as one of five patterns: acute cholangitis/pericholangitis (ACP), lymphocytic cholangitis (LC), granulomatous (G), ductopenia (D), or non-specific (NS). Read More

Am J Surg Pathol 2004 Sep;28(9):1193-203

Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.

Sclerosing cholangitis (SC) is a heterogeneous disease entity. Different etiologies such as choledocholithiasis, biliary tumor, or pericholangitis can manifest as SC. Hepatic inflammatory pseudotumor (IP) is rarely associated with SC (sclerosing cholangitis associated with hepatic inflammatory pseudotumor; SC-hepatic IP), but sclerosing pancreatitis (SP) is not infrequently associated with bile duct lesions (sclerosing pancreatitis-associated sclerosing cholangitis; SP-SC). Read More

Med Sci Monit 2001 May;7 Suppl 1:114-7

Department of Infectious Diseases, Medical University in Gdańsk, ul. Smoluchowskiego 18, 80-214 Gdańsk, Poland.

Background: Magnetic resonance cholangiography is a relatively new method, hence it has not gained a proper status yet in the diagnostic algorithm in patients with bile duct diseases. Many authors believe that MRC is an effective method for the visualisation of bile ducts. The aim of the study is to evaluate MRC usefulness in patients with PSC. Read More

Toxicol Sci 2002 Apr;66(2):347-55

Toxicology Centre, 44 Campus Drive, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B3, Canada.

Naphthenic acids are the most significant environmental contaminants resulting from petroleum extraction from oil sands deposits. In this study, a mixture of naphthenic acids isolated from Athabasca oil sands (AOS) tailings pond water was used in acute and subchronic toxicity tests with rodents, in order to assess potential risks posed to terrestrial wildlife. Dosages were chosen to bracket worst-case environmental exposure scenarios. Read More

Am J Gastroenterol 2000 May;95(5):1130-8

Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

Objective: Cholestasis may result from diverse etiologies. We review chronic cholestatic disorders involving small intrahepatic bile ducts in the adult ambulatory care setting. Specifically, we discuss variant forms of primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) as well as other conditions that may present diagnostic and therapeutic difficulties. Read More

Arch Environ Contam Toxicol 2000 Feb;38(2):197-201

Department of Biology and Ocean Sciences Centre, Memorial University of Newfoundland, St. John's, Newfoundland, Canada, A1B 3X9.

A study was conducted to determine the influence of decontamination on winter flounder living downstream from a pulp and paper mill. The fish and controls were held 8-26 weeks under contaminant-free conditions in aquaria supplied with ambient sea water. Groups of flounder, for comparison, were also sampled near the paper mill at the time of or following autopsy. Read More

Exp Toxicol Pathol 1999 Jul;51(4-5):326-9

Department of Biochemistry, Ege Univ. Medical School, Bornova, Izmir, Turkey.

Carmustine [1 ,3-bis(2-chloroethyl)-1-nitrosurea (BCNU)] is an antitumour agent, however, its usefulness has been limited by a side effect; which involves pericholangitis and intrahepatic cholestasis. The primary effects of cholestasis is well known; bile flow retention, intracellular Ca++ accumulation and acidosis although it may lead to hepatotoxicity by dose-dependent manner. Recent studies provide evidence that lipoperoxidation (LPO) and alterations in the antioxidant system may significantly contribute to BCNU induced hepatotoxicity. Read More

Gastroenterol Clin North Am 1999 Jun;28(2):491-513

Department of Internal Medicine, University of Arkansas for Medical Sciences College of Medicine, McClellan VA Hospital (VR), Little Rock, USA.

PSC is the most common of the clinically significant hepatobiliary diseases seen in association with IBD, with an incidence that varies from 2.5% to 7.5%. Read More

Rev Clin Esp 1999 Apr;199(4):258-9

J Clin Microbiol 1999 May;37(5):1536-47

Department of Companion Animal and Special Species Medicine, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA.

Human Bartonella infections result in diverse medical presentations, whereas many cats appear to tolerate chronic bacteremia without obvious clinical abnormalities. Eighteen specific-pathogen-free cats were inoculated with Bartonella henselae- and/or Bartonella clarridgeiae-infected cat blood and monitored for 454 days. Relapsing bacteremia did not correlate with changes in protein profiles or differences in antigenic protein recognition. Read More

Ned Tijdschr Geneeskd 1998 Oct;142(40):2232