Search Our Scientific Publications & Authors

Sci Rep 2017 07 19;7(1):5921. Epub 2017 Jul 19.

Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA.

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor (AhR). Male C57BL/6 mice orally gavaged with TCDD (0.01-30 µg/kg) every 4 days for 28 days exhibited bile duct proliferation and pericholangitis. Read More

Scand J Gastroenterol 2017 Mar 16;52(3):321-327. Epub 2016 Nov 16.

a Clinic of Gastroenterology, Department of Medicine , Helsinki University Hospital , Helsinki , Finland.

Objective: In autoimmune hepatitis, data on the prognostic value of baseline liver biopsy and the sequential histology is controversial. Our aim was to evaluate the prognostic value of clinical variables and biopsy at the time of diagnosis and during the disease course.

Materials And Methods: All 98 patients in our hospital during 1995-2012 were included. Read More

Hepatobiliary Surg Nutr 2015 Feb;4(1):E1-7

1 Cirugía Hepato-pancreática y Biliar, Departamento de Cirugía y Traumatología, Universidad de La Frontera, Temuco, Chile ; 2 Cirugía Hepato-pancreática y Biliar, Departamento de Cirugía, Clínica Alemana de Temuco, Temuco, Chile ; 3 Departamento de Imágenes Clínica Alemana de Temuco, Facultad de Medicina Clínica Alemana-Universidad del Desarrollo, Temuco, Chile ; 4 Departamento de Patología, Universidad de La Frontera, Temuco, Chile ; 5 Laboratorio de Inmunoparasitología Molecular CEGIN, Departamento de Ciencias Preclínicas, Universidad de La Frontera, Temuco, Chile ; 6 Departamento de Medicina Interna, Universidad de La Frontera, Temuco, Chile ; 7 Servicio de Gastroenterología, Clínica Alemana de Temuco, Temuco, Chile.

Human fascioliasis is a rare zoonosis in Chile. Clinically it presents with a highly polymorphous group of symptoms that evolve in two periods. The first, acute or a result of hepatic invasion, lasts 2 weeks to 4 months and is characterized essentially by pain in the right hypochondrium and/or epigastrium, continuous fever and painful hepatomegaly. Read More

Am J Surg Pathol 2014 Dec;38(12):1636-43

*Department of Pathology, Massachusetts General Hospital and Harvard School of Medicine, Boston, MA †Carolinas Pathology Group, Carolinas Medical Center, Charlotte, NC ‡Infectious Disease Associates of Kansas City, Kansas City, MO.

Syphilis, a sexually transmitted infection caused by the spirochete Treponema pallidum, has seen a resurgence since 2001, particularly in men who have sex with men. Syphilis can affect the liver during the secondary stage as syphilitic hepatitis and during the tertiary stage as gummas. We describe 3 cases of syphilis in human immunodeficiency virus-positive homosexual men that presented as hepatic mass lesions clinically suspected of being malignant tumors. Read More

Int J Clin Exp Pathol 2013 15;6(4):771-9. Epub 2013 Mar 15.

Institute of Pathology, University Hospital, Erlangen, Germany.

Hepatic angiomyolipoma (AML) is rare. Based on its wide histomorphological range, several distinctive histological variants have been delineated. However, hepatic AML displaying predominantly or exclusively inflammatory pattern closely mimicking inflammatory pseudotumor (IPT) is exceptionally rare with only 7 cases reported so far. Read More

Environ Toxicol Pharmacol 2011 Jul 4;32(1):82-101. Epub 2011 Apr 4.

Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.

The purpose of this study was to investigate the potential acute and 28-day repeated oral toxicities of besifloxacin (BAF) in Wistar albino rats. In oral acute and repeated dose study, BAF was administered to both sex of rats, at dose levels of 0, 300, 600, 900 mg/kg/day and 0, 100, 200, 500 mg/kg/day, respectively. In the acute study, total white blood cell (WBC) (male, 43. Read More

Vet Parasitol 2011 Dec 17;182(2-4):181-92. Epub 2011 May 17.

Marine Zoology Unit, Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia, PO Box 22085, 46071 Valencia, Spain.

Sparidae are economically important fishes to both, fisheries and aquaculture in the Mediterranean. Species diversification is an important strategy for the development of Mediterranean aquaculture. One of the species recently introduced is the sharpsnout seabream Diplodus puntazzo (Walbaum, 1792). Read More

Curr Ther Res Clin Exp 2010 Apr;71(2):118-28

Department of Biostatistics, Faculty of Medicine, Trakya University, Edirne, Turkey.

Background: Hydatid disease is a worldwide health problem. Treatment is surgical or percutaneous, using scolicidal agents. Caustic sclerosing cholangitis might develop after the contact of scolicidal agents with the biliary ducts. Read More

Inflamm Bowel Dis 2010 Sep;16(9):1598-619

Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

Diseases involving the hepatopancreatobiliary (HPB) system are frequently encountered in patients with inflammatory bowel disease (IBD). Hepatobiliary manifestations constitute some of the most common extraintestinal manifestations of IBD. They appear to occur with similar frequency in patients with Crohn's disease or ulcerative colitis. Read More

Sci Total Environ 2010 Apr 18;408(9):2136-45. Epub 2010 Jan 18.

Department of Environmental Sciences G. Sarfatti, University of Siena, Siena, Italy.

The aim of the present study was to evaluate the environmental threat to benthic species from chemical weapons dumped in the southern Adriatic Sea. An ecotoxicological approach using chemical analysis and biological responses was applied, in two sentinel species: the Blackbelly rosefish Helicolenus dactylopterus and European conger Conger conger. Specimen were collected in a stretch of sea, where had been dumped war materials and from a reference site free of ordnance. Read More

HPB (Oxford) 2006 ;8(2):153-5

Department of Surgery, Hospital General de Granollers, Barcelona, Spain.

Idiopathic fibrosing pancreatitis has been associated with Sjögren's syndrome, primary biliary cirrhosis and primary sclerosing cholangitis. This condition frequently develops in childhood and youth, and has also been related to ulcerative colitis and pericholangitis. Pancreatic complications have been rarely described as systemic complications of ulcerative colitis. Read More

Folia Parasitol (Praha) 2007 Jun;54(2):109-16

Israel Oceanographic and Limnological Research Ltd., National Center for Mariculture, Eilat 88112, Israel.

Two species of Coccomyxa Léger et Hesse, 1907, one of the least studied myxosporean genera, are reported from shallow coastal waters in the Gulf of Eilat, Red Sea, Israel. A new species, Coccomyxajirilomi sp. n. Read More

Am J Pathol 2007 Aug 28;171(2):525-36. Epub 2007 Jun 28.

Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University Graz, Austria.

Xenobiotics and drugs may lead to cholangiopathies and biliary fibrosis, but the underlying mechanisms are largely unknown. Therefore, we aimed to characterize the cause and consequences of hepatobiliary injury and biliary fibrosis in 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-fed mice as a novel model of xenobiotic-induced cholangiopathy. Liver morphology, markers of inflammation, cell proliferation, fibrosis, bile formation, biliary porphyrin secretion, and hepatobiliary transporter expression were studied longitudinally in DDC- and control diet-fed Swiss albino mice. Read More

J Comp Pathol 2006 Feb-Apr;134(2-3):134-42. Epub 2006 Mar 9.

Forschungs- und Technologiezentrum Westküste, Christian-Albrechts-Universität zu Kiel, 25761 Buesum, Germany.

A study of 37 by-caught harbour porpoises from Icelandic and Norwegian waters showed that most were in good or moderate nutritional condition and none was severely emaciated. Mild infection with lungworms (Halocercus invaginatus, Pseudalius inflexus, Torynurus convolutus) was found in 84% of the Icelandic and 91% of the Norwegian animals, usually associated with bronchopneumonia which was rarely severe. Most (91%) of the animals had parasites in the stomach and intestine (Anisakis simplex, Contracaecum osculatum, Pholeter gastrophilus), and Campula oblonga was present in the liver and pancreas of 88 and 21%, respectively. Read More

Pathol Res Pract 2005 ;201(8-9):565-72

Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

Inflammatory disorders of the biliary tract present difficult diagnostic problems in liver needle biopsies. The aim of this study was to perform a detailed histologic analysis of liver biopsies from patients with biliary tract disorders, classify them by pattern of inflammation, and determine the accuracy of the histologic classification by clinical follow-up. Percutaneous liver needle biopsies from the surgical pathology files of UmassMemorial Healthcare (UMMHC) from 2000 to 2003 with a diagnosis suggesting a biliary tract process (n = 32) and four biopsies from cases with systemic non-biliary tract disorders were analyzed for multiple histologic features and classified as one of five patterns: acute cholangitis/pericholangitis (ACP), lymphocytic cholangitis (LC), granulomatous (G), ductopenia (D), or non-specific (NS). Read More

Am J Surg Pathol 2004 Sep;28(9):1193-203

Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.

Sclerosing cholangitis (SC) is a heterogeneous disease entity. Different etiologies such as choledocholithiasis, biliary tumor, or pericholangitis can manifest as SC. Hepatic inflammatory pseudotumor (IP) is rarely associated with SC (sclerosing cholangitis associated with hepatic inflammatory pseudotumor; SC-hepatic IP), but sclerosing pancreatitis (SP) is not infrequently associated with bile duct lesions (sclerosing pancreatitis-associated sclerosing cholangitis; SP-SC). Read More

Med Sci Monit 2001 May;7 Suppl 1:114-7

Department of Infectious Diseases, Medical University in Gdańsk, ul. Smoluchowskiego 18, 80-214 Gdańsk, Poland.

Background: Magnetic resonance cholangiography is a relatively new method, hence it has not gained a proper status yet in the diagnostic algorithm in patients with bile duct diseases. Many authors believe that MRC is an effective method for the visualisation of bile ducts. The aim of the study is to evaluate MRC usefulness in patients with PSC. Read More

Toxicol Sci 2002 Apr;66(2):347-55

Toxicology Centre, 44 Campus Drive, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B3, Canada.

Naphthenic acids are the most significant environmental contaminants resulting from petroleum extraction from oil sands deposits. In this study, a mixture of naphthenic acids isolated from Athabasca oil sands (AOS) tailings pond water was used in acute and subchronic toxicity tests with rodents, in order to assess potential risks posed to terrestrial wildlife. Dosages were chosen to bracket worst-case environmental exposure scenarios. Read More

Am J Gastroenterol 2000 May;95(5):1130-8

Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

Objective: Cholestasis may result from diverse etiologies. We review chronic cholestatic disorders involving small intrahepatic bile ducts in the adult ambulatory care setting. Specifically, we discuss variant forms of primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) as well as other conditions that may present diagnostic and therapeutic difficulties. Read More

Arch Environ Contam Toxicol 2000 Feb;38(2):197-201

Department of Biology and Ocean Sciences Centre, Memorial University of Newfoundland, St. John's, Newfoundland, Canada, A1B 3X9.

A study was conducted to determine the influence of decontamination on winter flounder living downstream from a pulp and paper mill. The fish and controls were held 8-26 weeks under contaminant-free conditions in aquaria supplied with ambient sea water. Groups of flounder, for comparison, were also sampled near the paper mill at the time of or following autopsy. Read More

Exp Toxicol Pathol 1999 Jul;51(4-5):326-9

Department of Biochemistry, Ege Univ. Medical School, Bornova, Izmir, Turkey.

Carmustine [1 ,3-bis(2-chloroethyl)-1-nitrosurea (BCNU)] is an antitumour agent, however, its usefulness has been limited by a side effect; which involves pericholangitis and intrahepatic cholestasis. The primary effects of cholestasis is well known; bile flow retention, intracellular Ca++ accumulation and acidosis although it may lead to hepatotoxicity by dose-dependent manner. Recent studies provide evidence that lipoperoxidation (LPO) and alterations in the antioxidant system may significantly contribute to BCNU induced hepatotoxicity. Read More

Gastroenterol Clin North Am 1999 Jun;28(2):491-513

Department of Internal Medicine, University of Arkansas for Medical Sciences College of Medicine, McClellan VA Hospital (VR), Little Rock, USA.

PSC is the most common of the clinically significant hepatobiliary diseases seen in association with IBD, with an incidence that varies from 2.5% to 7.5%. Read More

Rev Clin Esp 1999 Apr;199(4):258-9

J Clin Microbiol 1999 May;37(5):1536-47

Department of Companion Animal and Special Species Medicine, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA.

Human Bartonella infections result in diverse medical presentations, whereas many cats appear to tolerate chronic bacteremia without obvious clinical abnormalities. Eighteen specific-pathogen-free cats were inoculated with Bartonella henselae- and/or Bartonella clarridgeiae-infected cat blood and monitored for 454 days. Relapsing bacteremia did not correlate with changes in protein profiles or differences in antigenic protein recognition. Read More

Ned Tijdschr Geneeskd 1998 Oct;142(40):2232

Mayo Clin Proc 1998 Mar;73(3):285-91

Division of Anatomic Pathology, Mayo Clinic Rochester, MN 55905, USA.

Idiopathic adulthood ductopenia (IAD), named only 10 years ago, is the latest entity to join the group of small-duct biliary diseases. On the basis of published data and my consultation practice, I am aware of 57 cases. Most commonly, IAD affects young or middle-aged adults (overall range of affected patients, 15 to 77 years) and occurs with a distinct male preponderance. Read More

Liver Transpl Surg 1997 Nov;3(6):559-62

Department of Pediatrics, University of California, San Francisco Medical Center, 94143-0136, USA.

Many centers perform biopsies on transplanted livers annually to assess allograft function because serum biochemical tests do not always correlate with histological findings. Although criteria exist for diagnosing acute cellular rejection, no similar criteria exist to describe the histopathological changes observed in the "normal" liver of an immunosuppressed but healthy child. The purpose of this study was to define the histopathological changes in the allografted livers of healthy children who have undergone transplantation and to evaluate them during long-term follow-up. Read More

Cas Lek Cesk 1997 Feb;136(4):106-10

II. interní klinika 1. LF UK a VFN, Praha.

Extraintestinal manifestations and metabolic complications are very frequent in patients with idiopathic inflammations of the gut and are encountered in at least 35% of these patients. In Crohn's disease extraintestinal manifestations are more frequent than in ulcerative colitis, in particular when the large bowel is affected. Metabolic complications are the result of inflammatory changes of the small intestine or develop as a result of the reduced reabsorption surface of the gut. Read More

Gac Med Mex 1996 Jul-Aug;132(4):433-7

Departamento de Admisión Continuay Toxicología, Hospital de Pediatría, México D.F., México.

We present a case of acute lethal poisoning by oil of "epazote" (oil of chenopodium), in a 2 y 9 m female. The volatile oil was administered according to the advice of a "curandera" (female healer), in a total quantity of 40 ml. Clinical features of the poisoning were: vomiting, deep coma, seizures, mydriasis, apnea, metabolic acidosis, neurogenic shock and death. Read More

J Gastroenterol 1996 Jun;31(3):347-52

First Department of Internal Medicine, Hirosaki University School of Medicine, Japan.

Rabbit colitis has been induced by injection of muramyl dipeptide emulsified with a long-chain fatty acid. The muramyl dipeptide emulsion was injected submucosally at six portions of the rectum and colon, 10 cm proximal to the anus, using a flexible endoscope. Six rabbits were injected six times every 2 weeks and subsequently killed 2 weeks after the last injection. Read More

J Gastroenterol 1996 Apr;31(2):199-206

First Department of Internal Medicine, Hirosaki University School of Medicine, Aomori, Japan.

We examined whether extraintestinal manifestations of granulomatous enterocolitis in rabbits might be produced by the long-term administration of muramyl dipeptide which represents the basic fragment of the bacterial cell wall, emulsified with Freund's incomplete adjuvant. Muramyl dipeptide emulsion was injected submucosally at six sites in the rectum and colon, 10 cm proximal to the anus, each time with a flexible endoscope. Seven rabbits were injected nine times or more every month, and all were sacrificed 1 month after the last injection. Read More

J Hepatol 1995 Feb;22(2):219-25

Digestive System Research Unit, Hospital General Vall d'Hebron, Barcelona, Spain.

We investigated the effects of the hapten trinitrobenzenesulfonic acid instilled into the rat biliary tree. The study included three groups of animals that received a single intracholedochal injection of either saline, 10% ethanol or 10 mg trinitrobenzenesulfonic acid dissolved in 10% ethanol. A fourth group of rats was subjected to common bile duct ligation and was used as control for biliary obstruction. Read More

Invest Radiol 1994 Oct;29(10):882-9

Department of Radiology, Wakayama Medical College, Japan.

Rationale And Objectives: The authors studied the acute toxicity of percutaneous transcatheter hepatic artery infusion of iodized poppy oil fatty acid ester (Lipiodol, Laboratoire Guerbet, Aulnay-sous-Bois, France).

Methods: Lipiodol dosages of 0, 0.25, 0. Read More

Hepatogastroenterology 1994 Jun;41(3):267-70

Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

A 42-year-old man with Behçet's disease of the intestinal type and a chronic cholestatic profile is presented. He had oral aphthea, genital ulcer, erythema nodosum, thrombophlebitis and central retinitis during the clinical course. Deep ileal ulcers recurred with massive bleeding and perforation. Read More

J Pediatr Surg 1994 May;29(5):639-44

Second Department of Surgery, Kyoto University, Faculty of Medicine, Japan.

To clarify the pathogenesis of pericholangitis in biliary atresia, immunohistochemical and ultrastructural methods were used to quantify the amount of collagen types III and IV, and alpha-smooth muscle actin-positive myofibroblast present in the pericholangial tissue. Patients were divided into two groups: the early-stage group (n = 7; 15 to 30 days old at the time of the Kasai operation), and the advanced-stage group (n = 14; 8 months to 6 years old at the time of liver transplantation). The liver specimen was harvested at the time of the Kasai operation in the early-stage group, and during liver transplantation in the advanced-stage group. Read More

Gastroenterology 1994 Jan;106(1):248-51

Department of Medicine, University of Florida, Gainesville.

A 51-year-old heart transplant recipient who developed subfulminant hepatic failure because of organ-transmitted hepatitis C virus (HCV) infection is described. He presented with a predominantly cholestatic liver damage after heart transplantation. An extensive evaluation, including abdominal ultrasound and computed tomography scan and endoscopic retrograde cholangiopancreatography was unrevealing. Read More

Am J Gastroenterol 1993 Aug;88(8):1174-8

Section of Gastroenterology, University of Chicago Medical Center, Illinois.

Known risk factors for the development of dysplasia and cancer in ulcerative colitis (UC) patients are: 1) increased extent and duration of disease and 2) increased age at symptom onset. This case-control study was performed to determine whether cholestatic liver disease is associated with neoplastic transformation. Twenty-nine UC patients with extensive disease of long duration and dysplasia or cancer detected in a cancer surveillance program were pair-matched to UC patients without neoplasia from a large inflammatory bowel disease registry matched on extent of disease, sex, and calendar year of disease onset. Read More

Am J Gastroenterol 1993 Aug;88(8):1151-4

Southeast Asian J Trop Med Public Health 1993 Jun;24(2):333-9

Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur.

Two groups of three rabbits each were infected with 250 cercariae of the Baling and Koyan strain of Schistosoma malayensis. Changes induced by both strains included periportal hepatocellular necrosis and fibrosis. Vascular changes such as portal phlebitis and thrombophlebitis and varying degrees of pericholangitis were also present. Read More

Aliment Pharmacol Ther 1993 Apr;7(2):201-6

University Hospital Sestre Milosrdnice, Zagreb Department of Gastroenterology, Republic of Croatia.

The aim of this study was to evaluate the influence of methylprednisolone (1 mg/kg, i.p.) on inflammatory lesions in the small bowel, liver (pericholangitis) and spleen (lymphofollicular proliferation), in a model of inflammatory bowel disease induced by 2. Read More

Intern Med 1992 Oct;31(10):1228-32

Second Department of Internal Medicine, Kobe University School of Medicine, Japan.

A 35-year-old woman was diagnosed as autoimmune hepatitis 12 years ago by abnormal findings of liver tests including lupus erythematosus (LE) cell phenomenon and liver biopsy. She was admitted in May 1990 with a history of lower gastrointestinal bleeding. Colonoscopy with biopsy and barium enema revealed chronic ulcerative colitis along the entire colon. Read More

J Pediatr Gastroenterol Nutr 1992 Aug;15(2):208-12

Department of Pediatrics, University of Louisville School of Medicine, Kosair Children's Hospital, Kentucky 40292.

Int J Clin Lab Res 1992 ;21(4):314-7

Istituto di Medicina Interna, Universitá di Milano, Italy.

Fifty patients with ulcerative colitis, 24 with Crohn's disease, and 50 controls were studied by liver function tests and abdominal ultrasound scan. Twenty-two percent of ulcerative colitis patients, 29% of Crohn's disease patients, and none of the controls showed abnormal liver function tests. All subjects with abnormal liver function tests also had changes in ultrasound liver scan, consisting of hepatomegaly and/or a dysechoic liver echo pattern. Read More

Scand J Gastroenterol 1992 ;27(3):184-8

University Hospital, Zagreb, Croatia, Yugoslavia.

The aim of this study was to develop a model of inflammatory bowel disease (IBD) induced by colonic application of 2,4-dinitrofluorobenzene in previously sensitized BALB-c mice. During the follow-up period of 30 days we observed ulcerations, haemorrhage, necrosis, and mononuclear infiltration in the colonic mucosa of previously sensitized (experimental) and, to a lesser extent, nonsensitized (control) animals. In addition, the animals in the experimental group developed adhesions, thickening of colonic segments, stenosis, and dilatation of the colon, and some animals also developed megacolon. Read More

Gastroenterology 1991 Jun;100(6):1743-8

Department of Hepatology, University of Miami School of Medicine, Florida.

A cholestatic syndrome caused by sclerosing cholangitis and papillary stenosis has been described in patients with the acquired immunodeficiency syndrome and hepatobiliary cryptosporidiosis and cytomegalovirus infection. The case of a 41-year-old homosexual man with the acquired immunodeficiency syndrome who presented with abdominal pain, diarrhea, fever, and cholestasis is reported. A percutaneous transhepatic cholangiogram showed that the extrahepatic and right-sided intrahepatic ducts were normal. Read More

Semin Liver Dis 1991 Feb;11(1):11-7

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905.

Current evidence suggests that PSC may affect the entire biliary system from interlobular bile ducts to the ampulla of Vater. If the affected bile ducts are too small for cholangiographic identification, the best designation for the condition is small-duct PSC; cholangiographically identifiable duct changes are the hallmark of large-duct PSC. The term "small-duct PSC" should replace the name pericholangitis because that designation lacks a clear definition. Read More

Eur J Cancer 1991 ;27(5):630-8

Laboratoire d'anatomo-pathologie et de cytologie pathologique, Hôpital Charles Nicolle, C.H.U., Rouen, France.

Chloroethylnitrosoureas are reactive compounds that are highly effective against malignant neoplasms in humans and animals. The most widely used nitrosoureas, lomustine and carmustine, are known to be hepatotoxic and to induce pericholangitis and intrahepatic cholestasis, which in the long term lead to cholangiolysis and biliary cirrhosis. However, the nitrosourea fotemustine has proved to be non-hepatotoxic at 20 mg/kg and 50 mg/kg. Read More

Liver 1990 Aug;10(4):239-48

Department of Paediatrics, Karolinska Institutet, Huddinge University Hospital, Sweden.

During a 12-year period, 46 children and adolescents with inflammatory bowel disease were followed from the time of diagnosis with regular biochemical tests of liver function. Thirty-four patients had ulcerative colitis and 12 had Crohn's disease. Mean age at the time of diagnosis was 10. Read More

Vestn Khir Im I I Grek 1989 Jul;143(7):3-7

An investigation of specific course of the disease in 911 patients operated upon for acute cholecystitis with bilirubinemia has shown that mechanical jaundice resulting from choledocholithiasis takes place in a third of the patients. Obstruction of the bile duct was confirmed in 27.1% of the patients during cholangiography. Read More

Southeast Asian J Trop Med Public Health 1989 Mar;20(1):95-100

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

The pathology of human opisthorchiasis in 22 adults (20 to 68 years) and 7 children (7 to 15 years) at autopsy is described. The changes of the liver in adults and children are similar and are summarized as follows: Enlargement of the liver was a common finding. Pericholangitis was observed in most cases. Read More