- Georgia Liantinioti,
- Antonios A Argyris,
- Athanase D Protogerou,
- Panayiotis Vlachoyiannopoulos
Curr Pharm Des 2018 Jan 15. Epub 2018 Jan 15.
Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens. Greece.
Colchicine has been longstanding and widely used for the treatment of acute gout flares and prevention of gout relapses. Its use has been extended to a series of autoinflammatory diseases, such as familial Mediterranean fever and more recently to periodic fever with aphthous stomatitis, pharyngitis and adenitis, Behcet's disease and idiopathic recurrent acute pericarditis. In this review, we summarize current indications of colchicine use, discuss its pharmacokinetics and mechanism of action and examine its use in the treatment of autoinflammatory diseases. Read More