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    Surgical treatment of left ventricular wall rupture, regarded as a consequence of Takotsubo cardiomyopathy.
    SAGE Open Med Case Rep 2017 18;5:2050313X16689210. Epub 2017 Jan 18.
    Scientific Research Institute of Heart Surgery and Organ Transplantation, Bishkek, Kyrgyzstan.
    Objective: We present the case of possible reverse type of TCM in a female patient presented with progressive left ventricular dysfunction and its rupture in pericardium.

    Methods: The detailed history, physical examination, laboratory tests, electrocardiography, serial echocardiography, coronary angiography with left ventriculography were performed to diagnose possible Takotsubo cardiomyopathy in 63-year old woman admitted to our center with complaints of dyspnea, lightheadedness, weakness and signs of hypotension and history of inferior myocardial infarction, acute left ventricular aneurysm, and effusive pericarditis and pleuritis, developed after emotional stress 5 months ago.

    Results: Clinical evaluation revealed unremarkable laboratory tests, normal troponin values, signs of old inferior myocardial infarction on electrocardiogram, and left ventricular (LV) dilatation and dysfunction, akinesia of LV infero-lateral wall with thinning and its rupture and blood shunting in pericardium. Read More

    Transthoracic Echocardiography: Pitfalls and Limitations as Delineated at Cardiac CT and MR Imaging.
    Radiographics 2017 Feb 17:160105. Epub 2017 Feb 17.
    From the Department of Diagnostic Imaging, Kaiser Permanente Los Angeles Medical Center, 1505 N Edgemont Ave, Basement, Los Angeles, CA 90027.
    Transthoracic echocardiography ( TTE transthoracic echocardiography ) is a critical tool in the field of clinical cardiology. It often serves as one of the first-line imaging modalities in the evaluation of cardiac disease owing to its low cost, portability, widespread availability, lack of ionizing radiation, and ability to evaluate both anatomy and function of the heart. Consequently, a large majority of patients undergoing a cardiac computed tomography (CT) or magnetic resonance (MR) imaging examination will have a TTE transthoracic echocardiography available for review. Read More

    Association of serum intact fibroblast growth factor 23 with left ventricular mass and different echocardiographic findings in patients on hemodialysis.
    J Transl Int Med 2016 Sep 23;4(3):135-141. Epub 2016 Sep 23.
    Department of Nephrology, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran (Islamic Republic of).
    Objectives: To determine the association of fibroblast growth factor 23 (FGF23) with left ventricular hypertrophy (LVH) through the assessment of left ventricular (LV) mass and left ventricular mass index (LVMI) in patients on hemodialysis, this study was done.

    Methods: All patients on hemodialysis who are older than 18 years and in whom hemodialysis vintage was at least 6 months were enrolled. All patients were on hemodialysis thrice a week for 4 h using low-flux dialysis filters, polysulfone membranes, reverse osmosis purified water, and bicarbonate-base hemodialysis solution. Read More

    Cardiac Toxicity After Radiotherapy for Stage III Non-Small-Cell Lung Cancer: Pooled Analysis of Dose-Escalation Trials Delivering 70 to 90 Gy.
    J Clin Oncol 2017 Jan 23:JCO2016700229. Epub 2017 Jan 23.
    Kyle Wang, Michael J. Eblan, Matthew Lipner, Timothy M. Zagar, Panayiotis Mavroidis, Carrie B. Lee, Brian C. Jensen, Julian G. Rosenman, and Lawrence B. Marks, University of North Carolina Hospitals; Allison M. Deal and Yue Wang, Lineberger Comprehensive Cancer Center Biostatistics Core, University of North Carolina Hospitals, Chapel Hill; Thomas E. Stinchcombe, Duke University Hospitals, Durham, NC; and Mark A. Socinski, Florida Hospital Cancer Institute, Orlando, FL.
    Purpose The significance of radiotherapy (RT) -associated cardiac injury for stage III non-small-cell lung cancer (NSCLC) is unclear, but higher heart doses were associated with worse overall survival in the Radiation Therapy Oncology Group (RTOG) 0617 study. We assessed the impact of heart dose in patients treated at our institution on several prospective dose-escalation trials. Patients and Methods From 1996 to 2009, 127 patients with stage III NSCLC (Eastern Cooperative Oncology Group performance status, 0 to 1) received dose-escalated RT to 70 to 90 Gy (median, 74 Gy) in six trials. Read More

    Boerhaave's syndrome: diagnostic gastroscopy.
    Rev Esp Enferm Dig 2017 Jan;109(1):65-66
    Aparato Digestivo, CHUS.
    A 47-year-old man was attended at the emergency room for severe chest pain after eating sausage with subsequent vomiting and mild upper gastrointestinal bleeding. In the chest radiography we could not see abnormalities. He referred previous episodes of choking without consulting. Read More

    Mixed Connective Tissue Disorder Complicated by Polymyositis, Sjogren's Syndrome, Pleural Effusion and Pericarditis.
    Cureus 2016 Dec 1;8(12):e906. Epub 2016 Dec 1.
    Department of Internal Medicine, Carthage Area Hospital, New York, USA.
    We report a case of a 24-year-old female with a history of asthma and gastroesophageal reflux disease (GERD). She presented to the emergency room with severe chest pain, chest tightness, and shortness of breath following an upper respiratory tract infection. The patient reported that she had a cough and runny nose one week prior to this presentation, followed by a sudden sharp pain in the center of the chest 8/10 in intensity on the visual analog scale and pleuritic in nature, which aggravated by deep breathing and lying down flat. Read More

    TRAUMATIC (FOREIGN BODY) PERICARDITIS IN A TOCO TOUCAN (RAMPHASTOS TOCO).
    J Zoo Wildl Med 2016 Dec;47(4):1097-1100
    An approximately 10-yr-old, captive-born female toco toucan ( Ramphastos toco ) was presented due to an acute onset of depression and apathy. On visual and physical examination, it showed an abnormal posture and dehydration, respectively. Serum biochemistry revealed hyperuricemia (39. Read More

    First case report of myopericarditis linked to Campylobacter coli enterocolitis.
    BMC Infect Dis 2017 Jan 5;17(1). Epub 2017 Jan 5.
    Department of Microbiology, Canberra Hospital and Health Services, Canberra, 2605, ACT, Australia.
    Background: Campylobacter spp. are a common cause of mostly self-limiting enterocolitis. Although rare, pericarditis and myopericarditis have been increasingly documented as complications following campylobacteriosis. Read More

    Carcinomatous pleuritis and pericarditis accompanied by pulmonary tuberculosis.
    Respirol Case Rep 2016 Nov 31;4(6):e00202. Epub 2016 Oct 31.
    Department of Respiratory Medicine Juntendo University Graduate School of Medicine Tokyo Japan.
    Although both lung cancer and pulmonary tuberculosis (TB) commonly occur in clinical practice, little attention has been paid to their coexistence. A 62-year-old female was admitted with acute dyspnoea secondary to cardiac tamponade. During her admission, a mass lesion harbouring air bronchograms in the right upper lobe rapidly increased in size. Read More

    Tuberculous pericarditis: a case report.
    Infez Med 2016 12;24(4):337-339
    Department of Cardiology, Faculty of Medicine, Firat University, Elazig, Turkey.
    Pericardial effusion is common disease and difficult to diagnose. Tuberculosis accounts for up to 4% of acute pericarditis and 7% of cardiac tamponade cases. Quick treatment can be lifesaving but requires accurate diagnosis. Read More

    Visceral and tissular reactivity in acute heart failure due to supraventricular tachyarrhythmia in a young patient.
    Rom J Morphol Embryol 2016 ;57(3):1099-1105
    Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, Romania;
    Observation of major pathological alterations in a young person involves etiological and clinical justifications, in order to properly assess, treat and control these conditions. The aim of this paper is to present severe, acute pathological lesions, installed in a young person, secondary to hypodiastolic heart failure, due to persistent supraventricular tachyarrhythmia, triggered by a post-traumatic external stimulus, with complete remission post-electrical conversion. Pathological and clinical modification are revealed, in a young person, shortly after a minor thoracic trauma, in the absence of traumatic injury but with high-frequency palpitations onset and progressive installation of vascular, visceral and interstitial stasis modifications, as well as of vascular and tissular hypoperfusion with reactive vasoconstriction. Read More

    Efficacy of anakinra in an adult patient with recurrent pericarditis and cardiac tamponade as initial manifestations of tumor necrosis factor receptor-associated periodic syndrome due to the R92Q TNFRSF1A variant.
    Int J Rheum Dis 2016 Dec 19. Epub 2016 Dec 19.
    Department of Internal Medicine, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Spain.
    Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a dominantly inherited autoinflammatory disease caused by TNFRSF1A mutations. Patients with TRAPS suffer from recurrent, long episodes with fever, arthralgia/arthritis, migratory myalgias, abdominal pain, serositis, conjunctivitis and migratory erythematous skin rash. More than 70 different TNFRSF1A mutations have been reported to date, and as consequence of its genetic heterogeneity, TRAPS shows a variable phenotypic expression. Read More

    [Cardiac causes of chest pain].
    Internist (Berl) 2017 Jan;58(1):8-21
    Klinik für Kardiologie, Angiologie und internistische Intensivmedizin, Universitäres Herzzentrum Marburg, Uniklinikum Gießen und Marburg, Standort Marburg, Baldingerstr., 35043, Marburg, Deutschland.
    Because of the life-threatening character and a high prevalence in emergency rooms, cardiac causes are important differential diagnoses of acute chest pain with the need for rapid clarification. In this context the working diagnosis "acute coronary syndrome" (ACS) plays a major role. In a synopsis of the clinical presentation, medical history, electrocardiogram and analysis of cardiac biomarkers, ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI) and unstable angina pectoris can be specified as entities of ACS. Read More

    Acute Pericarditis.
    Prog Cardiovasc Dis 2017 Jan - Feb;59(4):349-359. Epub 2016 Dec 10.
    Lenox Hill Heart and Vascular Institute of New York, New York, NY, United States. Electronic address:
    Acute pericarditis is an acute inflammatory disease of the pericardium, which may occur in many different disease states (both infectious and non-infectious). Usually the diagnosis is based on symptoms (chest pain, shortness of breath), electrocardiographic changes (ST elevation), physical examination (pericardial friction rub) and elevation of cardiac biomarkers. It may occur in isolation or be associated with an underlying inflammatory disorder. Read More

    Prognostic implications of epicardial fat volume quantification in acute pericarditis.
    Eur J Clin Invest 2017 Feb 30;47(2):129-136. Epub 2016 Dec 30.
    1st Cardiology Department, Hippokration Hospital, Athens Medical School, Athens, Greece.
    Background: The pathophysiology of acute pericarditis remains largely unknown, and biomarkers are needed to identify patients susceptible to complications. As adipose tissue has a pivotal role in cardiovascular disease pathogenesis, we hypothesized that quantification of epicardial fat volume (EFV) provides prognostic information in patients with acute pericarditis.

    Materials And Methods: Fifty (n = 50) patients with first diagnosis of acute pericarditis were enrolled in this study. Read More

    Pathophysiology of the Pericardium.
    Prog Cardiovasc Dis 2017 Jan - Feb;59(4):341-348. Epub 2016 Dec 1.
    Physiology and Biophysics, Case Western Reserve University, Cleveland, OH; University Hospitals Cleveland Medical Center, Cleveland, OH. Electronic address:
    Pericardial heart disease includes pericarditis, (an acute, subacute, or chronic fibrinous, noneffusive, or exudative process), and its complications, constriction, (an acute, subacute, or chronic adhesive or fibrocalcific response), and cardiac tamponade. The pathophysiology of cardiac tamponade and constrictive pericarditis readily explains their respective findings on clinical examination, Doppler echocardiography, and at cardiac catheterization. The primary abnormality of cardiac tamponade is pan-cyclic compression of the cardiac chambers by increased pericardial fluid requiring that cardiac chambers compete for a fixed intrapericardial volume. Read More

    Surgical experience on chronic constrictive pericarditis in African setting: review of 35 years' experience in Cote d'Ivoire.
    Cardiovasc Diagn Ther 2016 Oct;6(Suppl 1):S13-S19
    Department of Cardio-Vascular and Thoracic Surgery, Bouake Teaching Hospital, Bouake, Cote d'Ivoire.
    Background: Surgical experience with chronic constrictive pericarditis (CCP) is rarely documented in Africa; the aim of this study is therefore to review our African experience with CCP from 1977 to 2012 in terms of clinical and surgical outcomes and risk factors of early death after pericardiectomy.

    Methods: This retrospective study is related to 120 patients with CCP; there were 72 men and 48 women with an average age at 28.8±10. Read More

    Untying the Gordian knot of pericardial diseases: A pragmatic approach.
    Hellenic J Cardiol 2016 Nov 25. Epub 2016 Nov 25.
    Cardiology Department, University of Athens Medical School, Hippokration General Hospital, Athens, Greece.
    Pericardial disorders constitute a relatively common cause of heart disease. Although acute pericarditis, especially the idiopathic forms that are the most prevalent, is considered a benign disease overall, its short- and long-term complications, namely, recurrent pericarditis, cardiac tamponade and constrictive pericarditis, constitute a matter of concern in the medical community. In recent years, several clinical trials contributed to redefining our traditional approach to pericardial diseases. Read More

    Recent advances in the management of pericardial diseases.
    Hosp Pract (1995) 2016 Dec;44(5):266-273
    a Department of Cardiovascular and Thoracic , University Cardiology, AOU Città della Salute e della Scienza di Torino , Torino , Italy.
    Pericardial diseases are relatively common in clinical practice either as isolated diseases or part of an underlying or systemic disease. Recent advances in the diagnosis and treatment have greatly improved the clinical management and lead to consensus documents on multimodality imaging and new guidelines on the diagnosis and therapy of pericardial diseases. The aim of the present paper is to summarize available evidence in order to provide an updated and comprehensive review on the recent advances in the management of pericardial diseases. Read More

    Complicated Pericarditis: Understanding Risk Factors and Pathophysiology to Inform Imaging and Treatment.
    J Am Coll Cardiol 2016 Nov;68(21):2311-2328
    Department of Cardiovascular Imaging, Center for the Diagnosis and Treatment of Pericardial Disease, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:
    Most patients with acute pericarditis have a benign course and a good prognosis. However, a minority of patients develop complicated pericarditis, and the care of these patients is the focus of this review. Specifically, we address risk factors, multimodality imaging, pathophysiology, and novel treatments. Read More

    Pericarditis mimicking Brugada syndrome: A case report.
    Am J Emerg Med 2016 Nov 9. Epub 2016 Nov 9.
    Emergency Department - USL UMBRIA1, Via V. Muller 1, Assisi, Perugia, Italy.
    Introduction: Brugada syndrome (BrS) is a genetic heart disorder due to alteration of the ion channels function that causes an impaired in the cardiac conduction system. It is characterized by an abnormal electrocardiogram pattern and may be complicated by malignant ventricular arrhythmias. Pericarditis is an inflammation of the pericardium and 90% of isolated cases of acute pericarditis are idiopathic or viral. Read More

    Sex-based differences in prevalence and clinical presentation among pericarditis and myopericarditis patients.
    Am J Emerg Med 2017 Feb 18;35(2):201-205. Epub 2016 Oct 18.
    Department of Cardiology, Tel-Aviv Sourasky Medical Center, Tel Aviv, affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Sex differences in heart diseases, including acute coronary syndrome, congestive heart failure, and atrial fibrillation, have been studied extensively. However, data are lacking regarding sex differences in pericarditis and myopericarditis patients.

    Objectives: The purpose of the study was to evaluate whether there are sex differences in pericarditis and myopericarditis patients as well. Read More

    Acute Cardiac Tamponade in a 58-Year-Old Male with Poststreptococcal Glomerulonephritis.
    Methodist Debakey Cardiovasc J 2016 Sep;12(3):175-176
    Virginia Commonwealth University Health System, Richmond, Virginia; Hunter Holmes McGuire VA Medical Center, Richmond, Virginia.
    Pericarditis in conjunction with nephritis is an uncommon clinical scenario with a broad differential diagnosis. We present the case of a 58-year-old male who developed nephritis and pericardial effusion with tamponade physiology. In the following, we discuss the differential diagnosis for concomitant nephritis and pericarditis and discuss the work-up performed on our patient. Read More

    [The physical examination - a vanishing art?]
    Dtsch Med Wochenschr 2016 Oct 4;141(22):1636-1638. Epub 2016 Nov 4.
    This report describes the case of a 63-year-old female patient who presented with progressive dyspnea to a specialized internal medicine practice. Prior consultations with her primary care physician and a cardiologist followed by hospitalizations in an acute care hospital and in a specialist clinic for cardiology had not yielded a conclusive diagnosis. During the physical examination, significant bilateral lower extremity edema, as well as pronounced jugular venous distention was noted while in a seated position. Read More

    Kawasaki disease in Sicily: clinical description and markers of disease severity.
    Ital J Pediatr 2016 Nov 2;42(1):92. Epub 2016 Nov 2.
    NEUROFARBA Department University of Florence, and AOU Meyer, Florence, Italy.
    Background: Kawasaki disease (KD) is an acute systemic vasculitis of small and middle size arteries; 15-25 % of untreated patients and 5 % of patients treated with intravenous immunoglobulin (IVIG) develop coronary artery lesions (CAL). Many studies tried to find the most effective treatment in the management of resistant KD and to select the risk factors for CAL. Our data are assessed on children from west Sicily, characterized by a genetic heterogeneity. Read More

    DNA microarray-mediated transcriptional profiling of avian pathogenic Escherichia coli O2 strain E058 during its infection of chicken.
    Microb Pathog 2016 Nov 26;100:1-9. Epub 2016 Aug 26.
    Animal Infectious Disease Laboratory, Ministry of Agriculture, Jiangsu Co-innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, PR China. Electronic address:
    Avian pathogenic Escherichia coli (APEC) cause typical extraintestinal infections in poultry, including acute fatal septicemia, subacute pericarditis, and airsacculitis. These bacteria most often infect chickens, turkeys, ducks, and other avian species, and therefore pose a significant economic burden on the poultry industry worldwide. Few studies have analyzed the genome-wide transcriptional profile of APEC during infection in vivo. Read More

    Colchicine in addition to conventional therapy for pericarditis recurrence : An update meta-analysis.
    Herz 2016 Nov 15;41(7):630-638. Epub 2016 Mar 15.
    Health Division of Guard Bureau, General staff Department of Chinese PLA, Beijing, China.
    Background: Randomized controlled trials (RCTs) have investigated the use of colchicine and conventional therapy for reducing the recurrence of pericarditis in patients with acute pericarditis or post-pericardiotomy syndrome. However, the benefits of these treatments are variable.

    Methods: Studies were retrieved from PubMed, the Cochrane Library, and the EMBASE database. Read More

    A Case of Acute Pericarditis Following Intravenous Injection of Crushed Morphine Tablets.
    J Psychoactive Drugs 2016 Nov-Dec;48(5):355-358. Epub 2016 Oct 21.
    c Professor of Emergency Medicine, Division of Medical Toxicology, Department of Emergency Medicine , University of California San Diego , San Diego , CA , USA.
    A 37-year-old male presented with sharp, severe chest pain following seven days of intravenous injection of crushed morphine tablets. The chest pain was positional and pleuritic in nature and resolved with leaning forward. Work-up was notable for an ECG with inferior and anterolateral PR depressions as well as a CT chest with diffuse centrilobular nodules. Read More

    Pericardium: structure and function in health and disease.
    Folia Histochem Cytobiol 2016 21;54(3):121-125. Epub 2016 Sep 21.
    Department of Acquired Cardiac Defects, Institute of Cardiology, Warsaw, Poland.
    Normal pericardium consists of an outer sac called fibrous pericardium and an inner one called serous pericardium. The two layers of serous pericardium: visceral and parietal are separated by the pericardial cavity, which contains 20 to 60 mL of the plasma ultrafiltrate. The pericardium acts as mechanical protection for the heart and big vessels, and a lubrication to reduce friction between the heart and the surrounding structures. Read More

    CD20 negative B-cell lymphoma presenting as constrictive pericarditis: Rare etiology of acute heart failure.
    Indian Heart J 2016 Sep 20;68 Suppl 2:S253-S257. Epub 2016 Jan 20.
    Consultant Cardiothoracic Surgeon, Indo-US Super specialty Hospital, Shyam Karan Road, Ameerpet, Hyderabad, Telangana 500016, India.
    We describe a case report of a young girl, who presented with symptoms and signs of acute decompensated heart failure not responding to decongestive therapy. Routine 2D echocardiography revealed a diagnosis of constrictive pericarditis. She underwent pericardiectomy, and etiology of it turned out to be CD20 negative B-cell lymphoblastic primary cardiac lymphoma (PCL). Read More

    Hypersensitivity Eosinophilic Myocarditis in a Patient Receiving Multiple Drug Therapy: Challenges in Diagnosis and Defining the Aetiology.
    Drug Saf Case Rep 2016 Dec;3(1):11
    Department of Cardiovascular Diseases, University Hospital "Sveti Duh", Sveti Duh 64, 10000, Zagreb, Croatia.
    Eosinophilic myocarditis (EM) is a rare and potentially fatal disease if left untreated. Because the disease can have a delayed presentation and can appear even after 2 years, its underlying causes often remain unknown. We report the case of a 63-year-old man with an atypical clinical presentation of hypersensitive EM and significant coronary artery disease, which was confirmed through coronary angiography. Read More

    Fatal endocarditis with methicilin-sensible Staphylococcus aureus and major complications: rhabdomyolysis, pericarditis, and intracerebral hematoma: A case report and review of the literature.
    Medicine (Baltimore) 2016 Oct;95(41):e5125
    aDepartment of Infectious Diseases bDepartment of Anesthesiology and Intensive Care cDepartment of Internal Medicine dDepartment of Microbiology, University of Medicine and Pharmacy Tirgu Mures, Romania.
    Background: Over the last decades Staphylococcus aureus (SA) has become the dominant etiology of native valve infective endocarditis, with the community-acquired methicillin-sensible Staphylococcus aureus (CA-MSSA) strains being the prevailing type.

    Case: We report here a case of extremely severe CA-MSSA aortic valve acute endocarditis associated with persistent Staphylococcus aureus bacteremia (SAB) in a previously healthy man and include a literature review.The patient developed severe and rare complications (purpura, purulent pericarditis, intracerebral hematoma, and rhabdomyolysis) through systemic embolism; they required drainage of pericardial empyema and cerebral hematoma, the latter eventually caused a fatal outcome. Read More

    Fulminant myocarditis as a primary manifestation of H1N1 infection: A first reported case from Serbia.
    Hellenic J Cardiol 2016 May - Jun;57(3):181-184. Epub 2016 Jun 29.
    Clinic for Cardiology, Clinical Center Kragujevac, Zmaj Jovina bb, Kragujevac, Serbia.
    A 19-year-old male was admitted to our clinic with a diagnosis of suspected acute pericarditis and acute coronary syndrome. The initial diagnostics at our clinic revealed fulminant myocarditis. Twenty-four hours after admission, the patient's condition deteriorated, and he required mechanical ventilation and cardiopulmonary resuscitation. Read More

    [Troponin elevation in the absence of acute coronary syndrome].
    Ann Cardiol Angeiol (Paris) 2016 Nov 29;65(5):340-345. Epub 2016 Sep 29.
    Service de cardiologie, centre hospitalier Le Raincy-Montfermeil, rue du Général-Leclerc, 93370 Montfermeil, France.
    Cardiac troponins are the most sensitive and specific markers of myocardial injury. Cardiac troponin elevation are common in many diseases and do not necessarily indicate the presence of a thrombotic acute coronary syndrome. In clinical practice, interpretation of dynamic changes of troponin may be challenging. Read More

    Validation of the vessel-specific leads (VSLs) for detection of acute ischemia on a dataset with non-ischemic ST-segment deviation.
    J Electrocardiol 2016 Nov - Dec;49(6):800-806. Epub 2016 Aug 18.
    Dalhousie University, Halifax, NS, Canada.
    Background: Existing criteria recommended by ACC/ESC for identifying patients with ST elevation myocardial infarction (STEMI) from the 12-lead ECG perform with high specificity (SP) but low sensitivity (SE). In our previous studies, we found that the SE of acute ischemia detection can be markedly improved without any loss of SP by calculating, from the 12-lead ECG, ST deviation in 3 "optimal" vessel-specific leads (VSLs). To further validate the method, we evaluated the SP performance using a dataset with non-ischemic ST-segment changes. Read More

    Neisseria meningitidis presenting as acute abdomen and recurrent reactive pericarditis.
    Braz J Infect Dis 2016 Nov - Dec;20(6):641-644. Epub 2016 Sep 12.
    Medical School of Patras, University Hospital, Department of Internal Medicine, Rio, Greece; Medical School of Patras, University Hospital, Department of Infectious Diseases, Rio, Greece.
    Meningococcal meningitis is a well established potential fatal infection characterized by fever, headache, petechial rash, and vomiting in the majority of cases. However, protean manifestations including abdominal pain, sore throat, diarrhea and cough, even though rare, should not be overlooked. Similarly, although disseminated infection could potentially involve various organ-targets, secondary immune related complications including joints or pericardium should be dealt with caution, since they remain unresponsive to appropriate antibiotic regimens. Read More

    Molecular diagnosis of opportunistic pericardial infection in a patient treated with adalimumab: the role of next-generation sequencing.
    BMJ Case Rep 2016 Aug 29;2016. Epub 2016 Aug 29.
    Cardiovascular Department, "Ospedali Riuniti" and University of Trieste, Trieste, Italy.
    Biological immune-modulator drugs, especially inhibitors of tumor necrosis factor-α, are frequently encountered in modern clinical practice and opportunistic infections are therefore a common concern. Infective pericarditis has been described as a complication of these treatments with possible life-threatening consequences. In similar cases cultures may isolate multiple opportunistic bacteria from the pericardial fluid without specific identification of the responsible germ, representing a problem for targeted antibiotic therapy. Read More

    Middle East Respiratory Syndrome Virus Pathogenesis.
    Semin Respir Crit Care Med 2016 Aug 3;37(4):572-7. Epub 2016 Aug 3.
    Molecular Biology Unit, Institute of Medical Sciences, Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, India.
    Coronaviruses (CoVs) are enveloped RNA viruses that infect birds, mammals, and humans. Infections caused by human coronaviruses (hCoVs) are mostly associated with the respiratory, enteric, and nervous systems. The hCoVs only occasionally induce lower respiratory tract disease, including bronchitis, bronchiolitis, and pneumonia. Read More

    Simultaneous surgery in patients with both cardiac and noncardiac diseases.
    Patient Prefer Adherence 2016 18;10:1251-8. Epub 2016 Jul 18.
    Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, People's Republic of China.
    Background: To investigate the possibility and feasibility of simultaneous cardiac and noncardiac surgery.

    Methods: From August 2000 to March 2015, 64 patients suffering from cardiac and noncardiac diseases have been treated by simultaneous surgeries.

    Results: Two patients died after operations in hospital; thus, the hospital mortality rate was 3. Read More

    BET 1: Safety and efficacy of colchicine as stand-alone therapy for the prevention of recurrent pericarditis.
    Emerg Med J 2016 Aug;33(8):588-9
    Grand Rapids Medical Education Partners/Michigan State University, Michigan, USA.
    A short cut review was carried out looking for evidence of the benefits of using colchicine as a single therapy for acute pericarditis. A literature search was performed but no papers were found to provide evidence of the efficacy of colchicine without the concurrent use of Non-steriodal anti-inflammatory drugs (NSAIDs) for this condition. Read More

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