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    Heart dosimetric analysis of three types of cardiac toxicity in patients treated on dose-escalation trials for Stage III non-small-cell lung cancer.
    Radiother Oncol 2017 Oct 16. Epub 2017 Oct 16.
    Department of Radiation Oncology, University of North Carolina Hospitals, Chapel Hill, United States.
    Background And Purpose: To assess associations between radiation dose/volume parameters for cardiac subvolumes and different types of cardiac events in patients treated on radiation dose-escalation trials.

    Material And Methods: Patients with Stage III non-small-cell lung cancer received dose-escalated radiation (median 74 Gy) using 3D-conformal radiotherapy on six prospective trials from 1996 to 2009. Volumes analyzed included whole heart, left ventricle (LV), right atrium (RA), and left atrium (LA). Read More

    Fluid accumulation after closure of atrial septal defects: the role of colloid osmotic pressure.
    Interact Cardiovasc Thorac Surg 2017 Oct 10. Epub 2017 Oct 10.
    Department of Paediatric Cardiology, Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.
    Objectives: Following paediatric cardiac surgery with cardiopulmonary bypass (CPB), there is a tendency for fluid accumulation. The colloid osmotic pressure of plasma (COPp) and interstitial fluid (COPi) are determinants of transcapillary fluid exchange but only COPp has been measured in sick children. The aim of this study was to assess the net colloid osmotic pressure gradient in children undergoing atrial septal defect closure. Read More

    Cardiac tamponade in systemic lupus erythematosus.
    QJM 2017 Oct 17. Epub 2017 Oct 17.
    Department of Rheumatology, Institute of Post Graduate Medical Education and Research, Kolkata, India.
    Objectives: To describe incidence, risk factors and treatment of cardiac tamponade in a large cohort of Indian patients with systemic lupus erythematosus (SLE).

    Methods: This retrospective study was conducted at the Department of Rheumatology, IPGMER, Kolkata, India from May 2014 to December 2016 on admitted patients with SLE. Lupus-related serositis was diagnosed after excluding other causes, such as infection, malignancy or heart failure. Read More

    Lysozyme amyloidosis - a case report and review of the literature.
    Clin Nephrol Case Stud 2015 28;3:42-45. Epub 2015 Dec 28.
    Department of Medicine, Cleveland Clinic Foundation, OH, USA.
    Lysozyme amyloidosis is an exceedingly rare hereditary autosomal dominant amyloidosis, which is characterized by the precipitation of lysozyme protein within the body, leading to multi-organ dysfunction. Herein, we present the case of a U.S. Read More

    [Clinical, laboratory and instrumental criteria for myocarditis, established in comparison with myocardial biopsy: A non-invasive diagnostic algorithm].
    Ter Arkh 2017 ;89(9):30-40
    I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.
    Aim: To determine the diagnostic value of different clinical, laboratory, and instrumental signs in the diagnosis of myocarditis in patients with the picture of idiopathic arrhythmias, dilated cardiomyopathy (DCM) and in a comparison group when comparing with myocardial morphological examination.

    Subjects And Methods: A study group included 100 patients (35 women; mean age, 44.7±12. Read More

    A panel of markers for identification of malignant and non-malignant cells in culture from effusions.
    Oncol Rep 2017 Oct 11. Epub 2017 Oct 11.
    Pathology Department of Brasília University, Brasília, DF 71966-700, Brazil.
    The aim of the present study was to identify cell types in primary culture from malignant and non-malignant effusions. Effusion samples were subjected to cytology and culture. Immunocytochemistry was performed in cytological slides to evaluate malignancy (positivity for malignancy markers) and in culture slides for identification of cell types in growth. Read More

    Five Hundred Seventy-Six Cases of Video-Assisted Thoracic Surgery Utilizing Local Anesthesia and Sedation: Lessons Learned.
    J Am Coll Surg 2017 Oct 13. Epub 2017 Oct 13.
    Chairman, Department of Surgery and Surgeon-in-Chief, Sinai Hospital and Northwest Hospital, Baltimore, MA. Electronic address:
    Background: General anesthesia and endotracheal intubation are a luxury rather than a necessity for many video-assisted thoracic surgery (VATS) operations. Twenty-three years ago the author began utilizing local anesthesia and sedation for pleural disease and subsequently for pericardial and lung disease.

    Study Design: The records of all patients undergoing VATS utilizing local anesthesia and sedation at hospitals of the Geisinger Health System (Danville and Wilkes-Barre, PA) June 1, 2002 to June 30, 2011 and the Lifebridge Health System (Baltimore, MD) July 1, 2011 to March 1, 2017 were retrospectively reviewed. Read More

    Bayesian variable selection for a semi-competing risks model with three hazard functions.
    Comput Stat Data Anal 2017 Aug 22;112:170-185. Epub 2017 Mar 22.
    Department of Radiation Oncology, Unit 0097, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, U.S.A.
    A variable selection procedure is developed for a semi-competing risks regression model with three hazard functions that uses spike-and-slab priors and stochastic search variable selection algorithms for posterior inference. A rule is devised for choosing the threshold on the marginal posterior probability of variable inclusion based on the Deviance Information Criterion (DIC) that is examined in a simulation study. The method is applied to data from esophageal cancer patients from the MD Anderson Cancer Center, Houston, TX, where the most important covariates are selected in each of the hazards of effusion, death before effusion, and death after effusion. Read More

    Bleeding risk of submuscular ICD implantation with continued oral anticoagulation versus heparin bridging therapy.
    Heart Vessels 2017 Oct 13. Epub 2017 Oct 13.
    Department of Cardiology, St. Adolf-Stift Hospital Reinbek, Reinbek, Germany.
    Recent studies have shown that subcutaneous or subfascial pacemaker- and ICD implantation with continued oral anticoagulation therapy is associated with lower risk for bleeding complications, when compared to heparin bridging strategies. However, ICD generators are often implanted submuscularly. We therefore compared the bleeding risk with continued phenprocoumon therapy vs. Read More

    Emergency department point-of-care ultrasonography improves time to pericardiocentesis for clinically significant effusions.
    Clin Exp Emerg Med 2017 Sep 30;4(3):128-132. Epub 2017 Sep 30.
    Department of Emergency Medicine, Sheba Medical Center, Tel Hashomer, Israel.
    Objective: Our objective was to determine the utility of point-of-care ultrasound (POCUS) to identify and guide treatment of tamponade or clinically significant pericardial effusions in the emergency department (ED).

    Methods: This was a retrospective cohort study of non-trauma patients who were diagnosed with large pericardial effusions or tamponade by the ED physician using POCUS. The control group was composed of those patients later diagnosed on the medical wards or incidentally in the ED by other means such as a computed tomography. Read More

    Ketosis-prone diabetes and SLE co-presenting in an African lady with previous gestational diabetes.
    Endocrinol Diabetes Metab Case Rep 2017 6;2017. Epub 2017 Oct 6.
    Department of Diabetes and Endocrinology, Newham University Hospital, Barts Health NHS Trust, London, UK.
    We describe the case of an African woman who was diagnosed with ketosis-prone diabetes with diabetes-associated autoantibodies, after being admitted for diabetic ketoacidosis (DKA) precipitated by her first presentation of systemic lupus erythematosus (SLE). She had a seven-year history of recurrent gestational diabetes (GDM) not requiring insulin therapy, with return to normoglycaemia after each pregnancy. This might have suggested that she had now developed type 2 diabetes (T2D). Read More

    Percutaneous Therapy in Pericardial Diseases.
    Cardiol Clin 2017 Nov;35(4):567-588
    Department of Cardiology, Clinical Centre of Serbia, Belgrade University School of Medicine, Koste Todorovića 8, Belgrade 11000, Serbia.
    Interventional procedures for pericardial diseases include pericardiocentesis, drainage of pericardial effusion, intrapericardial therapy, and percutaneous balloon pericardiotomy or percutaneous pericardiostomy. Echocardiographic and fluoroscopic guidance have greatly increased safety and feasibility. Several devices for pericardiocentesis have been tested (PerDucer, PeriAttacher, visual puncture systems, Grasper, Scissors, and Reverse slitter), mainly to facilitate access to the pericardium in the absence of effusion for epicardial ablations or left atrial appendage ligation. Read More

    Effusive-Constrictive Pericarditis.
    Cardiol Clin 2017 Nov;35(4):551-558
    Department of Cardiovascular Diseases, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
    Effusive-constrictive pericarditis (ECP) corresponds to the coexistence of a hemodynamically significant pericardial effusion and decreased pericardial compliance. The hallmark of ECP is the persistence of elevated right atrial pressure postpericardiocentesis. The prevalence of ECP seems higher in tuberculous pericarditis and lower in idiopathic cases. Read More

    Cardiac Tamponade.
    Cardiol Clin 2017 Nov;35(4):525-537
    Department of Cardiovascular Medicine, Morristown Medical Center/Atlantic Health System, 100 Madison Avenue, Morristown, NJ 07960, USA.
    Cardiac tamponade is caused by an abnormal increase in fluid accumulation in the pericardial sac, which, by raising intracardiac pressures, impedes normal cardiac filling and reduces cardiac output, sometimes dramatically so. This article outlines the pathophysiology, clinical features, and treatment of this important clinical condition highlighting the important role played by echocardiography in diagnosis and management. Read More

    Pericardial Effusion.
    Cardiol Clin 2017 Nov;35(4):515-524
    Cardiology Unit, The University of Vermont Medical Center, The University of Vermont, 111 Colchester Avenue, Burlington, VT 05401, USA. Electronic address:
    The normal pericardial sac contains up to 50 mL of fluid, which consists of a plasma ultrafiltrate. Anything greater constitutes a pathologic effusion. The curvilinear pressure-volume relationship of the pericardial sac dictates hemodynamic consequences of a pericardial effusion and is responsible for rapidly accumulating fluid that causes cardiac tamponade. Read More

    Pericardial Effusion and Compressive Disorders of the Heart: Influence of New Technology on Unraveling its Pathophysiology and Hemodynamics.
    Cardiol Clin 2017 Nov;35(4):467-479
    Department of Cardiovascular Diseases, Mayo Clinic, 200 First Avenue Southwest, Rochester, MN 55905, USA. Electronic address:
    Constrictive pericarditis and cardiac tamponade cause severe diastolic dysfunction, but do not depress systolic function until the agonal state has been reached. Multimodality cardiovascular imaging has brought the nuances of pericardial disease to the domain of the practicing cardiologist. This introduction is a revised article originally written by the late Dr Shabetai for a pericardial diseases textbook which was not published. Read More

    Incidence and predictors of pericardial effusion as an early complication of catheter ablation for atrial fibrillation: The Japanese Catheter Ablation Registry of Atrial Fibrillation (J-CARAF).
    J Arrhythm 2017 Oct 12;33(5):430-433. Epub 2017 May 12.
    Heart Rhythm Center, Tokyo Medical and Dental University.
    Background: Pericardial effusion (PE) is one of the most frequent complications from catheter ablation of atrial fibrillation (AF). We assessed the prevalence and predictive factors of PE that require invasive treatment as an early complication of AF ablation.

    Methods: The Japanese Heart Rhythm Society requested electrophysiology centers to register the relevant data of patients who underwent AF ablation during 6 months from 2011 to 2015. Read More

    Successful treatment of community-acquired methicillin-resistant Staphylococcus aureus purulent myopericarditis.
    BMJ Case Rep 2017 Oct 10;2017. Epub 2017 Oct 10.
    Department of Cardiology, Naval Medical Center Portsmouth, Portsmouth, Virginia, USA.
    A previously healthy 48-year-old active duty man, who had been treated for an elbow abscess 3 weeks earlier, presented to an emergency department in Bahrain with tachycardia, pericardial friction rub and jugular venous distention. Cardiac tamponade was confirmed on transthoracic echocardiogram and he was taken for emergent pericardiocentesis. Pericardial fluid cultures grew community-acquired methicillin-resistant Staphylococcus aureus Despite ongoing treatment with intravenous vancomycin, he developed a recurrent fibrinous pericardial effusion and constrictive pericarditis requiring pericardiectomy. Read More

    Two episodes of cardiac tamponade in the same patient from removing pacing wires and a pericardial drain: A case report.
    Ann Card Anaesth 2017 Oct-Dec;20(4):459-461
    Department of Anesthesiology, Mount Sinai Medical Center, Miami Beach, Florida, USA.
    A patient presented for an elective transcatheter aortic valve replacement with temporary transvenous pacing (TVP) wires placement per protocol. On postoperative day 1, the patient remained stable, so the wires were subsequently removed, after which the patient acutely decompensated, with transthoracic echocardiography revealing pericardial effusion. Emergent pericardiocentesis was performed, and a pericardial drain was placed. Read More

    Evaluation of Pericardial Effusion in Dogs and Successful Treatment Using a Hemodialysis Fistula Needle: A Retrospective Study.
    Top Companion Anim Med 2017 Jun 30;32(2):72-75. Epub 2017 Aug 30.
    Department of Veterinary Sciences, University of Messina, Polo Universitario Annunziata, Messina, Italy. Electronic address:
    The aim of this retrospective study was to assess epidemiology and echocardiographic findings of pericardial effusion in canine patients and to determine the clinical usefulness and safety of a new pericardiocentesis technique, using a "fistula needle" for hemodialysis. A database of 5304 dogs of different breeds, age, gender, type, and severity of the cardiac disease, referred for a specialist cardiology and echocardiographic examination from 2009-2016, was reviewed. All the dogs were subjected to echocardiography; when possible and required, an echo-guided pericardiocentesis was performed by mean of a 17G "fistula needle" commonly used for hemodialysis. Read More

    Plasma N-terminal pro-brain natriuretic peptide concentrations before and after pericardiocentesis in dogs with cardiac tamponade secondary to spontaneous pericardial effusion.
    J Vet Cardiol 2017 Oct 4. Epub 2017 Oct 4.
    Department of Veterinary Clinical Sciences, Washington State University, PO Box 647060, Pullman, WA 99164-7060, United States.
    Objective: To determine if concentrations of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) are increased in dogs with cardiac tamponade and if there is a significant increase in plasma NT-proBNP after pericardiocentesis.

    Animals: Ten client-owned dogs with spontaneous cardiac tamponade.

    Methods: Prospective clinical study. Read More

    Safety profiles of percutaneous left atrial appendage closure devices: An analysis of the food and drug administration manufacturer and user facility device experience (MAUDE) database from 2009 - 2016.
    J Cardiovasc Electrophysiol 2017 Oct 8. Epub 2017 Oct 8.
    Division of Cardiovascular Diseases, Cardiovascular Research Institute, University of Kansas Hospital & Medical Center, Kansas City, KS, USA.
    Background: Percutaneous left atrial appendage closure (LAAC) is a viable option for AF patients who are unable to tolerate long term oral anticoagulation (OAC).

    Objective: We sought to assess the safety of two commonly used percutaneous devices for LAA closure in the United States by analysis of surveillance data from the FDA Manufacturer and User Facility Device Experience (MAUDE) database.

    Methods: The MAUDE database was queried between May 1, 2006 and May 1, 2016 for LARIAT® (SentreHEART Inc. Read More

    Perforations associated with peripherally inserted central catheters in a neonatal population.
    Pediatr Radiol 2017 Oct 6. Epub 2017 Oct 6.
    Division of Neonatology, Department of Pediatrics, The Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada.
    Background: Peripherally inserted central catheters (PICCs) are increasingly used in neonates but perforations can result in devastating complications such as pericardial and pleural effusions. Identifying risk factors may guide surveillance and reduce morbidity and mortality.

    Objective: To determine the risk factors for PICC perforation in neonates. Read More

    Peri-interventional combined anticoagulation and antithrombotic therapy in atrial fibrillation ablation: A retrospective safety analysis.
    Cardiol J 2017 Oct 5. Epub 2017 Oct 5.
    Kardiologie, Eberhard-Karls- Universität, Ottfried-Müller-Straße 10, 72076, Tübingen, Germany.
    Background: Catheter ablation (CA) of atrial fibrillation (AF) requires an intensified peri-interventional anticoagulation scheme to avoid thromboembolic complications. In patients with cardiac or extracardiac artery disease, an additional antiplatelet treatment (AAT) is at least temporally necessary especially after a percutaneous intervention with stent implantation. This raises the question whether these patients have a higher peri-interventional bleeding risk during CA of AF. Read More

    Severe Hypothyroidism due to the Loss of Therapeutic Efficacy of l-Thyroxine in a Patient with Esophageal Complication Associated with Systemic Sclerosis.
    Front Endocrinol (Lausanne) 2017 20;8:241. Epub 2017 Sep 20.
    Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
    Background: Thyroid function abnormalities and thyroid autoantibodies have been frequently described in patients with systemic autoimmune diseases as systemic sclerosis (SSc). Serum TSH levels are higher in SSc patients with more severe skin diseases and a worse modified Rodnan skin score. Asymptomatic esophageal involvement due to SSc has never been described as a cause of severe hypothyroidism due to l-thyroxine (l-T4) malabsorption in patients with Hashimoto's thyroiditis (HT) and SSc. Read More

    The Efficacy of Thoracic Ultrasonography in Postoperative Newborn Patients after Cardiac Surgery.
    Braz J Cardiovasc Surg 2017 Jul-Aug;32(4):283-287
    Department of Pediatric Cardiology, Istanbul Saglik Bilimleri University Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital, Istanbul, Turkey.
    Objective: In this study, the efficacy of thoracic ultrasonography during echocardiography was evaluated in newborns.

    Methods: Sixty newborns who had undergone pediatric cardiac surgery were successively evaluated between March 1, 2015, and September 1, 2015. Patients were evaluated for effusion, pulmonary atelectasis, and pneumothorax by ultrasonography, and results were compared with X-ray findings. Read More

    Antiplatelet Therapy in a Patient with Coronary Artery Disease and Myelodysplastic Syndrome with Thrombocytopenia.
    Acta Medica (Hradec Kralove) 2017 ;60(2):82-84
    Department of Internal Medicine, Complejo Hospitalario Universitario de Ferrol, Ferrol 15405, Spain.
    To date, there are no sufficient data to make firm recommendations on the treatment of patients with severe thrombocytopenia who require antiplatelet therapy after experiencing acute coronary syndrome. Therefore, we think that it is important to communicate the experience with individual cases. We report the case of a patient who presented with pericardial effusion causing cardiac tamponade. Read More

    Point-of-Care Ultrasound to Diagnose Postpericardiotomy Syndrome in a Child.
    Pediatr Emerg Care 2017 Oct;33(10):700-702
    From the *Division of Emergency Medicine, Boston Children's Hospital; and †Department of Pediatrics, Harvard Medical School, Boston, MA.
    We report a case of a patient presenting with abdominal pain after cardiac surgery who was noted on point-of-care ultrasound (POCUS) to have pericardial and pleural effusion, in addition to ascites. The most notable findings were pleural and pericardial effusions, which combined with symptomatology met criteria for postpericardiotomy syndrome. Point-of-care ultrasound expedited the diagnosis of a pericardial effusion with impending tamponade and transfer for pericardiocentesis and placement of pericardial drain. Read More

    Echocardiographic Evaluation of Hemodynamics in Neonates and Children.
    Front Pediatr 2017 15;5:201. Epub 2017 Sep 15.
    Department of Neonatology and Pediatric Cardiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
    Hemodynamic instability and inadequate cardiac performance are common in critically ill children. The clinical assessment of hemodynamic status is reliant upon physical examination supported by the clinical signs such as heart rate, blood pressure, capillary refill time, and measurement of the urine output and serum lactate. Unfortunately, all of these parameters are surrogate markers of cardiovascular well-being and they provide limited direct information regarding the adequacy of blood flow and tissue perfusion. Read More

    A Case Report of Primary Pericardial Malignant Mesothelioma Treated with Pemetrexed and Cisplatin.
    J Korean Med Sci 2017 Nov;32(11):1879-1884
    Division of Hematology/Oncology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
    Primary pericardial malignant mesothelioma (PPM) is a very rare malignancy, with an incidence of less than 0.002% and represents less than 5% of all mesotheliomas. The cause of pericardial mesothelioma is uncertain that differ from pleural mesothelioma which is associated with asbestos exposure. Read More

    Long-Term Survival of Patients with Pulmonary Arterial Hypertension at a Single Center in Taiwan.
    Acta Cardiol Sin 2017 Sep;33(5):498-509
    Department of Cardiology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
    Background: Clinical studies have suggested predictive parameters in mortality risk assessment for pulmonary arterial hypertension (PAH) patients. However, these studies predominantly include Caucasian population; information in Asian population is relatively deficient. In this study, we investigated the long-term survival of PAH patients and the predictors of mortality in our population. Read More

    Cardiac Auscultation for Noncardiologists: Application in Cardiac Rehabilitation Programs: PART I: PATIENTS AFTER ACUTE CORONARY SYNDROMES AND HEART FAILURE.
    J Cardiopulm Rehabil Prev 2017 Aug 4. Epub 2017 Aug 4.
    Preventive Cardiology and Rehabilitation, Istituto Codivilla-Putti, Cortina d'Ampezzo (BL), Italy (Drs Compostella, Compostella, Russo, Setzu, and Bellotto); Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padova, Italy (Drs Compostella, Russo, Iliceto, and Bellotto); and Department of Medicine, School of Emergency Medicine, University of Padua, Padova, Italy (Dr Compostella).
    During outpatient cardiac rehabilitation after an acute coronary syndrome or after an episode of congestive heart failure, a careful, periodic evaluation of patients' clinical and hemodynamic status is essential. Simple and traditional cardiac auscultation could play a role in providing useful prognostic information.Reduced intensity of the first heart sound (S1), especially when associated with prolonged apical impulse and the appearance of added sounds, may help identify left ventricular (LV) dysfunction or conduction disturbances, sometimes associated with transient myocardial ischemia. Read More

    New insights and new hope for pulmonary arterial hypertension: natriuretic peptides clearance receptor as a novel therapeutic target for a complex disease.
    Int J Physiol Pathophysiol Pharmacol 2017 1;9(4):112-118. Epub 2017 Sep 1.
    Egom Clinical & Translational Research Services Ltd.,Dartmouth, NS B3H 3H3, Canada.
    Background: Pulmonary Arterial Hypertension (PAH) is a deadly and disabling disease for which there is no marketed drug that addresses the underlying disease mechanism and targets to cure patients. The lack of understanding of the disease mechanism represents the main challenges in developing curative therapies. We here report, for the first time, that mice lacking natriuretic peptides clearance receptor develop PAH. Read More

    Incidence and Outcome of Pericardial Effusion in Pediatric Patients After Hematopoietic Stem Cell Transplant: A Single-institution Experience.
    J Pediatr Hematol Oncol 2017 Sep 22. Epub 2017 Sep 22.
    *Division of Pediatric Cardiology ‡Division of Pediatric Hematology/Oncology §Department of Medicine, Division of Biostatistics, University of Miami, Miller School of Medicine †Holtz Children's Hospital, Jackson Memorial Medical Center, Miami, FL.
    Background: Pericardial effusion (PE) is a known complication after hematopoietic stem cell transplant (HSCT). Limited data is currently available regarding the incidence and outcomes of PE in pediatric HSCT.

    Methods: We conducted a retrospective study on a cohort of patients who underwent HSCT between 2004 and 2015. Read More

    Left ventricular perforation after Impella® placement in a patient with cardiogenic shock.
    Catheter Cardiovasc Interv 2017 Sep 25. Epub 2017 Sep 25.
    Division of Cardiovascular Medicine, University of Utah Hospital, Utah.
    Mechanical cardiovascular support devices are now widely used both in the setting of cardiogenic shock as well as during high risk cardiac catheterization procedures. We report a case of a young female patient who presented with presumed myocarditis and rapidly deteriorating decompensated heart failure requiring the implantation of an Impella Circulatory Support System. Upon transfer to our facility it was discovered that during transport, the Impella device had migrated through the left ventricle. Read More

    Fulminant myocardial bleeding: another clinical course of vascular Ehlers-Danlos Syndrome.
    BMJ Case Rep 2017 Sep 23;2017. Epub 2017 Sep 23.
    Department of Cariovascular Medicine, Toho University Ohashi Medical Center, Tokyo, Japan.
    Vascular Ehlers-Danlos Syndrome (vEDS) is a dominantly inherited connective tissue disorder characterised by colon rupture and arterial aneurysm, dissection and rupture. A patient was diagnosed with vEDS after a spontaneous colon rupture when he was brought to our institute because of sudden chest pain. An ECG revealed wide regional ST elevation, which was initially suggestive of acute myocarditis. Read More

    Diagnosis of systemic inflammatory diseases among patients admitted for acute pericarditis with pericardial effusion.
    J Cardiovasc Med (Hagerstown) 2017 Nov;18(11):875-880
    aDépartement de Médecine Interne bDépartement d'Epidémiologie et Recherche Clinique cDépartement d'Information Médicale dDépartement de Cardiologie, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris eINSERM U1149 fDépartement Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and Remodelling in Renal and Respiratory Diseases), Paris, France.
    Aims: Acute pericarditis may be the heralding manifestation of various systemic inflammatory diseases (SIDs). The aim of this study was to identify clinical indicators for SIDs in patients admitted for acute pericarditis with pericardial effusion.

    Methods: All consecutive adult patients hospitalized in a Department of Internal Medicine over a 10-year period for acute pericarditis with pericardial effusion were retrospectively reviewed. Read More

    Intra-Pericardial Use of Recombinant Factor VIIa in a Patient With Acute Hemorrhagic Pericardial Effusion Following Transcutaneous Aortic Valve Replacement-A Case Report.
    Lab Med 2017 Aug;48(3):262-265
    The University of Texas Health Science Center at Houston, Department of Pathology and Laboratory Medicine.
    Perioperative bleeding can be a serious life-threatening complication in adult patients undergoing cardiac surgery, given the older age and additional comorbidities present in this patient population. The standard treatment options include transfusion of blood components and surgical re-exploration. We report the first case of an elderly female patient treated with local administration of recombinant factor VIIa (rFVIIa) for intractable hemorrhagic pericardial effusion, which developed following a transcutaneous aortic valve replacement (TAVR) procedure for severe aortic stenosis. Read More

    Catch me if you can-How to make the best use of pleural effusion.
    J Thorac Dis 2017 Aug;9(8):E664-E668
    The Geriatrics Department, Peking University First Hospital, Beijing 100034, China.
    Etiology diagnosis of pleural effusion is a commonly encountered yet challenging problem. How to make the best use of pleural effusion evokes thinking. Myelomatous pleural effusion (MPE) is a rare condition and has been reported sporadically. Read More

    Optimizing the Safety Profile of Everolimus by Delayed Initiation in De Novo Heart Transplant Recipients: Results of the Prospective Randomized Study EVERHEART.
    Transplantation 2017 Sep 19. Epub 2017 Sep 19.
    1Heart and Lung Transplant Program, Academic Hospital S. Orsola-Malpighi, Building 21, via Massarenti, 9, Bologna 40138, Italy; 2Cardiac Surgery Department, University of Pavia-Hospital Policlinico, San Matteo, Pavia, Italy; 3Transplant Surgery Department, Hospitals Colli - Monaldi, Naples, Italy; 4Cardiothoracic Surgery Department, Academic Hospital S. Maria della Misericordia, Udine, Italy; 5Heart Transplant Surgery Unit, Academic Hospital Senese, Siena, Italy; 6Cardiology 2 - Cardiac Insufficiency and Transplantation Department, Academic Hospital Niguarda, Milan, Italy; 7Cardiac Surgery Unit, Academic Hospital Civile Maggiore, Verona, Italy; 8Cardiac Surgery Unit, Hospital San Camillo Forlanini, Rome, Italy; 9Cardiac Surgery Unit, Academic Hospital of Padova, Padua, Italy; 10Cardiac Surgery Unit, Hospital of Bari, Bari, Italy; 11Cardiology Unit, Hospital G. Brotzu - San Michele, Cagliari, Italy; 12Cardiac Surgery Unit, Hospital Molinette, Turin, Italy.
    Background: Although everolimus potentially improves long-term heart transplantation (HTx) outcomes, its early postoperative safety profile had raised concerns and needs optimization.

    Methods: This 6-month, open-label, multicenter randomized trial was designed to compare the cumulative incidence of a primary composite safety endpoint comprising wound healing delays, pericardial effusion (PCEs), pleural effusion (PLEs) needing drainage, and renal insufficiency events (estimated glomerular filtration rate [eGFR] ≤30/mL/min/1.73 m) in de novo HTx recipients receiving immediate (≤144 h post-HTx; EVR-I) or delayed (4-6 weeks post-HTx with mycophenolate mofetil as a bridge; EVR-D) everolimus with reduced-dose cyclosporine A (CsA). Read More

    Reversible Causes in Cardiovascular Collapse at the Emergency Department Using Ultrasonography (REVIVE-US).
    Ann Acad Med Singapore 2017 Aug;46(8):310-316
    Emergency Medicine Department, National University Hospital, Singapore.
    Introduction: Ultrasonographic evaluation of patients in cardiac arrest is currently not protocolised in the advanced cardiac life support (ACLS) algorithm. Potentially reversible causes may be identified using bedside ultrasonography that is ubiquitous in most emergency departments (EDs). This study aimed to evaluate the incidence of sonographically detectable reversible causes of cardiac arrest by incorporating an ultrasonography protocol into the ACLS algorithm. Read More

    Effusive-Constrictive Pericarditis After Pericardiocentesis: Incidence, Associated Findings, and Natural History.
    JACC Cardiovasc Imaging 2017 Sep 9. Epub 2017 Sep 9.
    Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota. Electronic address:
    Objectives: This study sought to investigate the incidence, associated findings, and natural history of effusive-constrictive pericarditis (ECP) after pericardiocentesis.

    Background: ECP is characterized by the coexistence of tense pericardial effusion and constriction of the heart by the visceral pericardium. Echocardiography is currently the main diagnostic tool in the assessment of pericardial disease, but limited data have been published on the incidence and prognosis of ECP diagnosed by echo-Doppler. Read More

    Endomyocardial fibrosis in Sudan: clinical and echocardiographic features.
    Cardiovasc J Afr 2017 Jul/Aug;28(4):208-214
    Academy Teaching Hospital, Khartoum, Sudan.
    Objective: Endomyocardial fibrosis (EMF) is a rare disease and is often an underdiagnosed and forgotten cardiomyopathy. The objective of this study was to document the current frequency of EMF in Sudan by defining and selecting cases from patients attending the echocardiography laboratory. Additionally we aimed to create an EMF registry for Sudan. Read More

    Pericardial effusion is correlated with clinical outcome after pulmonary artery denervation for pulmonary arterial hypertension.
    Oncotarget 2017 Aug 20;8(33):54106-54114. Epub 2016 Dec 20.
    Columbia University Medical Center and the Cardiovascular Research Foundation, New York, NY, USA.
    Objectives: Pericardial effusion (PE) is correlated with outcomes in patients with pulmonary arterial hypertension (PAH). Pulmonary artery denervation (PADN) was used for treatment of PAH. The present study aimed to analyze the prognostic value of PE for outcomes after PADN in patients with WHO Group I, Group II and Group IV PAH. Read More

    Validation of a novel CARTOSEG™ segmentation module software for contrast-enhanced computed tomography-guided radiofrequency ablation in patients with atrial fibrillation.
    Pacing Clin Electrophysiol 2017 Sep 13. Epub 2017 Sep 13.
    Maryland Arrhythmia and Cardiology Imaging Group (MACIG).
    Introduction: Visualization of left atrial (LA) anatomy using image integration modules has been associated with decreased radiation exposure and improved procedural outcome when used for guidance of pulmonary vein isolation (PVI) in atrial fibrillation (AF) ablation. We evaluated the CARTOSEG™ CT Segmentation Module (Biosense Webster, Inc.) that offers a new CT-specific semiautomatic reconstruction of the atrial endocardium. Read More

    Emergency medicine evaluation and management of the end stage renal disease patient.
    Am J Emerg Med 2017 Sep 5. Epub 2017 Sep 5.
    Joint Base Elmendorf Richardson Medical Center, Department of Emergency Medicine, 5955 Zeamer Ave, JBER, AK, 99506, United States.
    Background: End stage renal disease (ESRD) is increasing in the U.S., and these patients demonstrate greater all-cause mortality, cardiovascular events, and hospitalization rates when compared to those with normal renal function. Read More

    POEMS Syndrome with Biclonal Gammopathy: A Rare Association.
    J Clin Diagn Res 2017 Jul 1;11(7):XD12-XD13. Epub 2017 Jul 1.
    Consultant, Department of Transfusion Medicine, The Mission Hospital, Durgapur, West Bengal, India.
    Polyneuropathy, Organomegaly, Endocrinopathy, M protein and Skin changes (POEMS) syndrome is rare plasma cell dyscrasia with multisystem involvement. The name comes from the five characteristic features: Polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes. The presence of biclonal M band is a rare manifestation. Read More

    Case report: A case of pericardial effusion presenting to primary care.
    Med J Malaysia 2017 Aug;72(4):252-253
    Universiti Putra Malaysia, Department of Family Medicine, Malaysia.
    This is a rare but interesting case of Mr. MZ who had a lifethreatening pericardial effusion presenting to the primary care clinic. Through great clinical acumen and prudent targeted investigations, diagnosis of this rare condition was reached and urgent referral made to the cardiology team which performed an emergency pericardiocentesis which proved to be life -saving. Read More

    Post-cardiac injury syndrome: an atypical case following percutaneous coronary intervention.
    Am J Emerg Med 2017 Sep 5. Epub 2017 Sep 5.
    Emergency Department, Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy. Electronic address:
    Post-cardiac injury syndrome (PCIS) is a syndrome characterized by pericardial and/or pleural effusion, triggered by a cardiac injury, usually a myocardial infarction or cardiac surgery, rarely a minor cardiovascular percutaneous procedure. Nowadays, the post-cardiac injury syndrome, is regaining importance and interest as an emerging cause of pericarditis, especially in developed countries, due to a great and continuous increase in the number and complexity of percutaneous cardiologic procedures. The etiopathogenesis seems mediated by the immunitary system producing immune complexes, which deposit in the pericardium and pleura and trigger an inflammatory response. Read More

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