6,618 results match your criteria Perianal Granuloma


68Ga-PSMA Uptake in Anal Fistula on PET/CT Scan.

Clin Nucl Med 2019 Jan;44(1):e54-e56

From the Departments of Nuclear Medicine and PET Centre, and.

Ga-prostate-specific membrane antigen (PSMA) PET/CT scan for primary staging discovered increased Ga-PSMA uptake in a known anal fistula in a recently diagnosed high-risk prostate cancer patient. The patient had an ongoing history of surgical revisions of complex fistulas in the perianal region, contributing to active inflammation and infection. Recently, reports have demonstrated increased Ga-PSMA uptake in different benign inflammatory conditions. Read More

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January 2019

Role of Vacuum-Assisted Closure in the Management of Crohn Anal Fistulas.

Adv Skin Wound Care 2018 Dec 13. Epub 2018 Dec 13.

At the Poznań University of Medical Sciences in Poznań, Poland, Jacek Hermann, PhD, is Chair, Department of General and Endocrine Surgery and Gastroenterologic Oncology; Tomasz Banasiewicz is Chair, Department of General and Endocrine Surgery and Gastroenterologic Oncology; and Barbara Kołodziejczak, PhD, is Chair, Department of Computer Science and Statistics. The authors have disclosed no financial relationships related to this article. Submitted January 28, 2018; accepted in revised form May 25, 2018.

Background: Patients with Crohn disease-related anal fistulas are treated with debridement of fistulous tracts and the placement of noncutting setons (NCSs). However, to reduce the high recurrence rate, there is still a need to develop more effective treatment methods.

Objective: To compare NCS with vacuum-assisted closure (VAC) treatment. Read More

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December 2018
1 Read

THE ONSET OF CLINICAL MANIFESTATIONS IN INFLAMMATORY BOWEL DISEASE PATIENTS.

Arq Gastroenterol 2018 Jul-Sep;55(3):290-295

Universidade do Estado da Bahia, Departamento de Ciências da Vida, Salvador, BA, Brasil.

Background: The diagnosis of inflammatory bowel disease is often delayed because of the lack of an ability to recognize its major clinical manifestations.

Objective: Our study aimed to describe the onset of clinical manifestations in inflammatory bowel disease patients.

Methods: A cross-sectional study. Read More

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October 2017

Safety and Efficacy of Rituximab in Multiple Sclerosis: A Retrospective Observational Study.

J Immunol Res 2018 12;2018:9084759. Epub 2018 Nov 12.

Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanon.

Objective: To evaluate the efficacy and safety of rituximab in multiple sclerosis in a clinical practice setting.

Methods: Clinical data for all adult patients with multiple sclerosis (MS) treated with off-label rituximab at a single MS center in Lebanon between March 2008 and April 2017 were retrospectively collected from medical charts. The main efficacy outcomes assessed were annualized relapse rate (ARR) and proportion of patients free from relapses, disability progression, or magnetic resonance imaging (MRI) activity. Read More

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November 2018

Investigation on spp. eggs in hair coat of dogs in YSR Kadapa district of Andhra Pradesh, India.

J Parasit Dis 2018 Dec 15;42(4):550-553. Epub 2018 Oct 15.

2Department of Veterinary Clinical Complex, College of Veterinary Science, Faculty of Veterinary Medicine, Sri Venkateswara Veterinary University, Proddatur, Andhra Pradesh 516 360 India.

Present study was aimed to record the spp. eggs in dog's hair and to analyze the incidence in breed and age wise along with incidence variations in the anatomical locations of hair over the body. Dogs presented to the hospital were screened for enteric parasitic ova and hair samples were collected from the different body regions including head and neck region, ventral and lateral abdomen, perianal and hindquarters and tail region. Read More

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December 2018

Local Stem Cell Therapy for Crohn's Perianal Fistulae.

Inflamm Bowel Dis 2018 Dec 11. Epub 2018 Dec 11.

Center for Inflammatory Bowel Disease, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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December 2018

Zoonotic multidrug-resistant microorganisms among small companion animals in Germany.

PLoS One 2018 7;13(12):e0208364. Epub 2018 Dec 7.

Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.

Antimicrobial multidrug-resistant microorganisms (MDRO) can be transmitted between companion animals and their human owners. Aim of this study was to determine the prevalence of extended spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) and Staphylococcus aureus including methicillin-resistant S. aureus (MRSA) in different companion animal species. Read More

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December 2018

Real-life experience with ceftolozane/tazobactam in patients with hematologic malignancy and infection: a case-control study.

Antimicrob Agents Chemother 2018 Dec 10. Epub 2018 Dec 10.

Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain.

Background: We present our experience in patients with hematologic malignancy and infection treated with ceftolozane-tazobactam.

Materials/methods: We performed a single-center case-control study including all patients with hematologic malignancy and infection treated with ceftolozane-tazobactam (study group) and compared them with similar patients not treated with ceftolozane-tazobactam (control group) to assess safety and efficacy.

Results: Nineteen cases and 38 controls were analyzed. Read More

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December 2018

Structured versus narrative reporting of pelvic MRI in perianal fistulizing disease: impact on clarity, completeness, and surgical planning.

Abdom Radiol (NY) 2018 Dec 5. Epub 2018 Dec 5.

Division of Abdominal Imaging/Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02115, USA.

Objective: To evaluate clarity, completeness, and impact on surgical planning of MRI reporting of perianal fistulizing disease using a structured disease-specific template versus narrative reporting for planning of disease treatment by colorectal surgeons.

Materials And Methods: In this HIPAA-compliant, IRB-approved study with waiver of informed consent, a structured reporting template for perianal fistulizing disease MRIs was developed based on collaboration between colorectal surgeons and abdominal radiologists. The study population included 45 consecutive patients who underwent pelvic MRI for perianal fistulizing disease prior to implementation of structured reporting, and 60 consecutive patients who underwent pelvic MRI for perianal fistulizing disease after implementation of structured reporting. Read More

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December 2018
3 Reads

Hidradenitis Suppurativa: Causes, Features, and Current Treatments.

J Clin Aesthet Dermatol 2018 Oct 1;11(10):17-23. Epub 2018 Oct 1.

Drs. Vinkel and Thomsen are with the Department of Dermatology at Bispebjerg Hospital in Copenhagen, Denmark.

Hidradenitis suppurativa (HS), a relatively common and chronic inflammatory skin disorder. HS can have debilitating consequences if not diagnosed and treated appropriately. Clinically defined by recurrent, inflamed nodules in intertriginous regions (i. Read More

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October 2018
2 Reads

Allergic Contact Dermatitis and Autoeczematization to Proctosedyl® Cream and Proctomyxin® Cream.

Case Rep Dermatol 2018 Sep-Dec;10(3):238-246. Epub 2018 Oct 24.

Department of Dermatology, University of Ottawa, Ottawa, Ontario, Canada.

Proctosedyl® and Proctomyxin® are two commonly prescribed hemorrhoid therapies. Their topical application to the perianal region may be complicated by a local allergic contact dermatitis and subsequent autoeczematization reaction. We present three cases of an autoeczematization (ID) reaction to varying topical allergens found in Proctosedyl®/Proctomyxin®. Read More

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October 2018
1 Read

Syphilis as an atypical cause of perianal fissure.

J Surg Case Rep 2018 Nov 27;2018(11):rjy320. Epub 2018 Nov 27.

General Surgery Department, Monash Health, Melbourne, Australia.

We present the case of a 29-year-old woman who attended a surgical outpatient clinic with symptoms of perianal fissure due to syphilitic infection. This uncommon aetiology of a common condition is often alluded to in textbooks, but little information exists in the scientific literature regarding the pathogenesis, presentation and treatment of fissure-in-ano secondary to syphilis. We present the case and an overview of the topic aimed at surgeons and clinicians who manage patients with perianal pathology. Read More

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November 2018
2 Reads

Combined management of perianal rhabdomyosarcoma with chemotherapy, radical surgery, and irradiation: A series of three consecutive children.

J Pediatr Surg 2018 Nov 7. Epub 2018 Nov 7.

Children's Hospital, Section of Pediatric Surgery, University of Helsinki, Finland.

Background And Aim: We describe a series of three successive patients with perianal rhabdomyosarcoma (PRMS) from 2014 to 2017 managed with combined chemotherapy, radical surgery, and radiotherapy.

Methods: Ethical consent was obtained. Data including tumor presentation, treatment, and survival was collected from hospital reports. Read More

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November 2018
1 Read

Predictors of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci co-colonization among nursing facility patients.

Am J Infect Control 2018 Nov 27. Epub 2018 Nov 27.

Department of Internal Medicine, Division of Geriatric and Palliative Medicine, University of Michigan Medical School, Ann Arbor, MI; Geriatrics Research Education and Clinical Center, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI.

Background: The emergence of vancomycin-resistant Staphylococcus aureus (VRSA) poses significant challenges for antibiotic therapy. We characterized the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) co-colonization that may facilitate resistance transfer and vancomycin-resistant S aureus emergence among nursing facility patients.

Methods: We cultured newly admitted patient hands, nares, oropharynx, groin, and perianal region plus wounds and device insertion sites, if applicable, upon enrollment at day 14, day 30, and monthly follow-up up to 6 months. Read More

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November 2018
1 Read

The importance of clinical approach in aggravated sexual abuse: Case report.

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):597-600

Department of Forensic Medicine, Manisa Celal Bayar University Faculty of Medicine, Manisa-Turkey.

The reported rate of sex crimes, some of the most severe acts of violence that can be perpetrated against an individual, is increasing across all societies, regardless of gender or age of the victim. Sexual abuse has been defined, in part, as the involvement of a child in sexual activity for which they are incapable of giving consent, that they cannot fully comprehend, or for which they are developmentally immature. Molestation of the anorectal region is frequently encountered when the victim of sexual abuse is a male child. Read More

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November 2018
3 Reads

Anogenital Verrucous Carcinoma-A case report.

Int J Surg Case Rep 2018 Nov 27;54:7-9. Epub 2018 Nov 27.

Department of Plastic Surgery and Breast Surgery, Zealand University Hospital, Roskilde, Denmark.

Introduction: Verrucous carcinoma is an uncommon variant of low-grade squamous cell malignancy with a low malignant potential but a high risk of recurrence.

Presentation Of Case: We report a case of a Human Papilloma Virus negative local verrucous carcinoma in the perianal area of a 45-year old otherwise healthy female. The tumor presented clinically as a persistent genital wart not responding to usual dermatologic local therapy. Read More

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November 2018
3 Reads

Anal Adenocarcinoma Can Masquerade as Chronic Anal Fistula in Asians.

Ann Coloproctol 2018 Dec 3. Epub 2018 Dec 3.

Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore.

Purpose: Perianal adenocarcinoma arising from a chronic anorectal fistula is a rare condition for which the natural history and optimal management are not well established. For that reason, we conducted a retrospective analysis of 5 consecutive patients with a perianal adenocarcinoma arising from a chronic anorectal fistula managed at our institution from January 2014 to December 2015.

Methods: The patients were identified from a prospectively collected colorectal cancer database that included all patients managed for colorectal cancer at our institution. Read More

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December 2018
2 Reads

Extramammary Paget's Disease.

Hematol Oncol Clin North Am 2019 Feb;33(1):73-85

Department of Dermatology, The Centers for Melanoma and Cutaneous Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA; Dana-Farber/Brigham and Women's Cancer Center, 450 Brookline Avenue, Boston, MA 02115, USA. Electronic address:

Extramammary Paget disease (EMPD) is a rare cutaneous malignancy most commonly affecting the genitals, perineum, and perianal area of the elderly. Despite its rarity, to those impacted, the disease and its treatment can have a tremendous impact on quality of life. Commonly confined to the epidermis, EMPD can be invasive, associated with contiguous extension or upward pagetoid spread of underlying malignancy or with distant synchronous malignancy. Read More

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February 2019
5 Reads

Burden and outcomes for complex perianal fistulas in Crohn's disease: Systematic review.

World J Gastroenterol 2018 Nov;24(42):4821-4834

Takeda, Deerfield, IL 60015, United States.

Aim: To systematically review the literature on epidemiology, disease burden, and treatment outcomes for Crohn's disease (CD) patients with complex perianal fistulas.

Methods: PubMed, Embase, and Cochrane were searched for relevant articles (published 2000-November 2016) and congress abstracts (published 2011-November 2016).

Results: Of 535 records reviewed, 62 relevant sources were identified (mostly small observational studies). Read More

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November 2018
5 Reads

[Clinical features of children with Kawasaki disease aged over 5 years].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Nov;20(11):917-920

Children's Hospital of Chongqing Medical University/National Demonstration Base of Standardized Training Base for Resident Physicians/Ministry of Education Key Laboratory of Child Development and Disorders/Key Laboratory of Pediatrics in Chongqing/Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing 400014, China.

Objective: To study the clinical and laboratory features of children with Kawasaki disease (KD) aged >5 years.

Methods: A retrospective analysis was performed for the clinical data of 250 elderly children (aged >5 years) who were diagnosed with KD or incomplete KD (divided into 5-9 years and >9 years groups) and 266 KD children aged 1-5 years. Clinical and laboratory features were compared between groups. Read More

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November 2018
5 Reads

Structured reporting of MRI for perianal fistula.

Abdom Radiol (NY) 2018 Nov 24. Epub 2018 Nov 24.

Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women's College Hospital, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

Objective: The purpose of this article is to review MRI technique, relevant anatomy, and MRI classification systems for the assessment of perianal fistulising disease. We present a stepwise approach to the assessment of perianal fistulas on MRI utilizing a systematic reporting format.

Conclusion: MRI is invaluable for the assessment of perianal fistulas. Read More

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November 2018
7 Reads

Negative Pressure Wound Therapy with Instillation and Dwell Time in the Surgical Management of Severe Hidradenitis Suppurativa.

Cureus 2018 Sep 17;10(9):e3319. Epub 2018 Sep 17.

Plastic and Reconstructive Surgery, University of Maryland School of Medicine, Baltimore, USA.

Background: Hidradenitis suppurativa (HS) is a physically debilitating disease that greatly impairs the quality of life of affected individuals. Advanced disease is often difficult to treat with topical and systemic therapies. Surgical resection of diseased skin has become paramount in HS management but proposes challenges of wound care and closure. Read More

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September 2018
5 Reads

First Aid Toolkit for Anal Fistulas, a Detailed Treatise for Trainees (Video Vignette ESCP Trainee Video).

Colorectal Dis 2018 Nov 24. Epub 2018 Nov 24.

ETZ Hospital, Tilburg, The Netherlands.

Fistula surgery is often performed by trainees. However, an inexperienced trainee may lay open a fistula that could be treated by a more conservative approach. There is considerable national and international variation and the present video will not attempt to define superior methods, but rather highlight matters of debate. Read More

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November 2018
10 Reads

Treatment of Perianal Sepsis, a Detailed Treatise for Trainees (Video Vignette ESCP Trainee Video).

Colorectal Dis 2018 Nov 24. Epub 2018 Nov 24.

ETZ Hospital, Tilburg, The Netherlands.

For many surgeons, the drainage of a perianal abscess is the first operation they perform unsupervised. However, this risks an adverse outcome if the young surgeon has not been well trained. Most surgeons believe perianal sepsis is caused by cryptoglandular infection. Read More

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November 2018
7 Reads

A fatal case of Fournier's gangrene during neoadjuvant radiotherapy for rectal cancer.

Strahlenther Onkol 2018 Nov 23. Epub 2018 Nov 23.

Department of Radiation Oncology, Leopoldina Hospital Schweinfurt, Robert-Koch-Straße 10, 97422, Schweinfurt, Germany.

Purpose: To report the development of an ultimately fatal occurrence of Fournier's gangrene in a rectal cancer patient undergoing neoadjuvant radiotherapy without chemotherapy.

Methods: A 53-year-old male patient with G2 cT3 cN1a cM0 stage IIIB adenocarcinoma of the lower rectum and several comorbidities including ulcerative colitis was treated with 56 Gy to the primary tumor in 28 fractions because he declined the recommended simultaneous chemotherapy. He was also enrolled in the ketogenic diet arm of our KETOCOMP study, so that prospective measurements of blood parameters, quality of life, and body composition were made. Read More

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November 2018
3 Reads

Long-term outcomes following restorative proctocolectomy ileal pouch-anal anastomosis in pediatric ulcerative colitis patients: Multicenter national study in Japan.

Ann Gastroenterol Surg 2018 Nov 27;2(6):428-433. Epub 2018 Jul 27.

Department of Internal Medicine Toho University Sakura Medical Center Sakura Chiba Japan.

Background: Few studies have investigated surgical outcomes following a colectomy in pediatric patients with ulcerative colitis (UC).

Purpose: This study aimed to determine long-term outcomes in a large cohort of pediatric patients who underwent proctocolectomy with ileal pouch-anal anastomosis (IPAA) for UC.

Methods: Pediatric patients (<17 years old) who underwent surgery at 12 different hospitals in Japan between May 1979 and March 2015 were included in this study. Read More

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November 2018
9 Reads

Anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramammary Paget disease, successfully treated with modified FOLFOX6: a case report.

BMC Cancer 2018 Nov 20;18(1):1142. Epub 2018 Nov 20.

Department of Gastroenterology, University of Tsukuba Hospital, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Background: Anal canal cancer occasionally accompanies extramammary Paget disease. Although most of them are squamous cell carcinoma, anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramammary Paget disease has never been reported.

Case Presentation: Here, we report a 76-year-old man presented with pruritus in the perianal area. Read More

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November 2018
4 Reads

A Dermatological Questionnaire for General Practitioners with a Focus on Hidradenitis Suppurativa.

Open Access Maced J Med Sci 2018 Oct 3;6(10):1902-1905. Epub 2018 Oct 3.

Department of Clinical Medicine and Surgery, Section of Dermatology and Venereology, University of Naples Federico II, Via Pansini 5, Naples, Italy.

Background: Hidradenitis suppurativa (HS) is a skin chronic inflammatory disease typically located in several areas such as perianal, inguinal and axillary regions. In 40% to 70% of cases, general practitioners (GPs) are the first health care professionals consulted by patients suffering from HS. The role of GPs in HS management could be more substantial than it has been in the past. Read More

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October 2018

Gut-Directed Pelvic Floor Behavioral Treatment for Fecal Incontinence and Constipation in Patients with Inflammatory Bowel Disease.

Inflamm Bowel Dis 2018 Nov 19. Epub 2018 Nov 19.

Department of Gastroenterology, St Vincent's Hospital, Melbourne and University of Melbourne, Melbourne, Australia.

Background: Patients with inflammatory bowel disease (IBD) often experience functional bowel symptoms despite achieving disease remission. Although behavioral treatment (bowel and pelvic floor muscle retraining) is effective for managing constipation or fecal incontinence in non-IBD patients, there is limited evidence for its efficacy in patients with quiescent inflammatory bowel disease. The aim of this study was to evaluate the outcome of gut-directed behavioral treatment, including pelvic floor muscle training, for symptoms of constipation or fecal incontinence in patients with IBD in disease remission. Read More

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November 2018
4 Reads

Extramammary Paget disease of the vulva (VEMPD) with perianal involvement: a 30-year experience.

G Ital Dermatol Venereol 2018 Nov 12. Epub 2018 Nov 12.

Woman's Health Sciences Department, Università Politecnica delle Marche, Ancona, Italy -

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November 2018
5 Reads

Nivolumab PD-1 inhibitor immunotherapy associated with vulvar, perineal and perianal lichen sclerosus.

Clin Exp Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, University Hospitals Birmingham NHS Foundation Trust, Mindelsohn Way, Birmingham, UK.

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November 2018
4 Reads

Anal human papillomavirus infection in HIV-positive men and women at two opportunistic infections clinics in Harare, Zimbabwe.

BMC Public Health 2018 Nov 14;18(1):1260. Epub 2018 Nov 14.

Department of Surgery, University of Zimbabwe College of Health Sciences, P.O. Box A178 Avondale, Harare, Zimbabwe.

Background: HIV-infected individuals are at increased risk of anal cancer; in the majority of cases this is linked to human papillomavirus (HPV) infection. Anal cancer screening is not routinely offered in Zimbabwe.

Methods: A cross-sectional study was performed on 152 patients (88 females; 64 males) attending Opportunistic Infection Clinics at 2 tertiary hospitals between November 2014 and June 2015. Read More

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November 2018
6 Reads

Phthirus pubis Infestation of the Scalp: A Case Report and Review of The Literature.

Korean J Parasitol 2018 Oct 31;56(5):487-489. Epub 2018 Oct 31.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

Phthirus pubis usually infests the pubis, groin, buttocks and perianal region. It can sometimes infest the thighs, abdomen, chest, axillae and beard. Eyelashes and eyebrows may be involved in children. Read More

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October 2018
4 Reads

Recent advance in very early onset inflammatory bowel disease.

Authors:
Jung Ok Shim

Intest Res 2018 Nov 12. Epub 2018 Nov 12.

Department of Pediatrics, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.

Recent studies on pediatric inflammatory bowel disease (IBD) have revealed that early-onset IBD has distinct phenotypic differences compared with adult-onset IBD. In particular, very early-onset IBD (VEO-IBD) differs in many aspects, including the disease type, location of the lesions, disease behavior, and genetically attributable risks. Neonatal or infantile-onset IBD develops in less than 1% of pediatric patients. Read More

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November 2018
7 Reads

Basal cell enumeration does not predict malignancy in canine perianal gland tumor cytology.

Vet Clin Pathol 2018 Nov 11. Epub 2018 Nov 11.

College of Veterinary Medicine and Biomedical Science, Colorado State University, Fort Collins, Colorado.

Background: Perianal (hepatoid) gland tumors are common in dogs, and the distinction between the benign and malignant forms is clinically important. Cytology of these tumors typically contains many large hepatoid cells and fewer small basal cells.

Objectives: The objective of this study was to determine whether the proportion of the smaller basaloid reserve cells in cytologic samples from perianal tumors correlates with malignancy. Read More

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November 2018
6 Reads

Efficacy of irrigation tubes in the management of para rectal cavities associated with complex fistula-in-ano.

BMC Surg 2018 Nov 9;18(1):95. Epub 2018 Nov 9.

Department of Surgery, Faculty of Medicine, University of Colombo, P.O. Box 271, Kynsey Road, Colombo 8, Western Province, Sri Lanka.

Background: Surgical management of complex perianal fistula associated with pararectal cavities can be challenging. We hypothesised that healing of the pararectal cavities prior to healing of the fistula leads to a better outcome. We aimed to assess the efficacy of irrigation catheters in the healing of pararectal cavities associated with fistula-in-ano. Read More

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November 2018
4 Reads

Loss of tolerance to glycoprotein 2 isoforms 1 and 4 is associated with Crohn's disease of the pouch.

Aliment Pharmacol Ther 2018 Dec 8;48(11-12):1251-1259. Epub 2018 Nov 8.

Department of Gastroenterology, Hepatology & Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

Background: Zymogen granule glycoprotein 2 (GP2) is a major autoantigen of Crohn's disease-specific pancreatic autoantibodies.

Aim: To test a link between loss of tolerance to isoforms of GP2 and pouch disorders in a cross-sectional study in ulcerative colitis patients with ileal pouch-anal anastomosis (IPAA).

Methods: Serum samples of 117 consecutive ulcerative colitis patients after IPAA were tested for presence of Anti-GP2 isoforms 1 (GP2 ) & 4 (GP2 ) IgG and IgA as well as anti-Saccaromyces cervisiae (ASCA) IgG and IgA antibodies in a blinded fashion via enzyme-linked immunosorbent assay. Read More

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December 2018
4 Reads

A proliferating trichilemmal cyst in the perianal region: A case report.

Int J Surg Case Rep 2018 Oct 18;53:175-178. Epub 2018 Oct 18.

University Hospital São Francisco de Assis na Providência de Deus, Bragança Paulista, São Paulo, Brazil; UNICAMP, Campinas, São Paulo, Brazil. Electronic address:

Introduction: Proliferating trichilemmal cysts (PTCs) are rare benign neoplasms originating from the follicular isthmus. They can undergo trichilemmal keratinization and malignant degeneration to form epidermoid carcinoma. They occur on the scalp in more than 90% of patients and are more common in elderly women. Read More

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October 2018
6 Reads

Rhabdomyolysis during myelosuppression in a patient with central nervous system leukemia: A case report.

Medicine (Baltimore) 2018 Nov;97(45):e13091

Hematology Department, First Affliated Hospital, Guangxi Medical University, Nanning, China.

Rationale: Rhabdomyolysis is a potentially life-threatening syndrome and is a rare complication in patients with acute leukemia.

Patient's Concerns: A 20-year-old male was admitted to our hospital due to skin ecchymosis in his trunk and lower limbs for 10 days.

Diagnoses: Based on the precise diagnosis of leukemia, namely cell morphology, immunology, cytogenetics, and molecular biological typing (MICM), the patient was diagnosed with acute T-lymphocytic leukemia (T-ALL). Read More

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November 2018

Factors Affecting Mortality in Fournier Gangrene: A Single Center Experience.

Surg Infect (Larchmt) 2018 Nov 7. Epub 2018 Nov 7.

Faculty of Medicine, Department of General Surgery, Kirikkale University , Kirikkale, Turkey .

Background: The objective of this study was to determine the clinical and laboratory features affecting mortality in Fournier gangrene.

Patients And Methods: This retrospective case control study was designed to evaluate patients treated for Fournier gangrene in our center between 2010 and 2018. Those patients were divided into two groups: discharged patients (group 1) and deceased patients (group 2). Read More

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November 2018
4 Reads

Type I AV fistula of the thoracic spinal cord.

Am J Emerg Med 2018 Oct 21. Epub 2018 Oct 21.

Department of Emergency Medicine, UPMC Hamot, Erie, PA, United States of America. Electronic address:

Type I AV fistulas of the spinal cord are exceedingly rare. The average age at diagnosis is 50. Clinical presentation is often very non-specific, and sensory deficits and sphincter dysfunction may also occur. Read More

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October 2018
4 Reads

A risk score system to timely manage treatment in Crohn's disease: a cohort study.

BMC Gastroenterol 2018 Nov 6;18(1):164. Epub 2018 Nov 6.

Dipartimento di Medicina Interna e Specialità Mediche, Università "Sapienza", Policlinico "Umberto I", V.le del Policlinico, 155, 00161, Rome, Italy.

Background: Clinical severity and intestinal lesions of Crohn's disease (CD) usually progress over time and require a step up adjustment of the therapy either to prevent or to treat complications. The aim of the study was to  develop a simple risk scoring system to assess in individual CD patients the risk of disease progression and the need for more intensive treatment and monitoring.

Methods: Prospective cohort study (January 2002-September 2014) including 160 CD patients (93 female, median age 31 years; disease behavior (B)1 25%, B2 55. Read More

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November 2018
9 Reads

Rates of Antibiotic Resistance / Sensitivity in Bacterial Cultures of Hidradenitis Suppurativa Patients.

J Eur Acad Dermatol Venereol 2018 Nov 5. Epub 2018 Nov 5.

Department of Medical Sciences Section of Dermatology, University of Ferrara, Italy.

Background: Antibiotic (AB) treatment is one of the first steps in the management of Hidradenitis Suppurativa (HS). Bacteria, in HS patients, may play a double role, as triggering factors of inflammatory reactions and/or agents of infection.

Objectives: The aims of this study are: 1) to assess prevalence and AB resistance of bacterial growths in HS patients 2) assessment of the clinical relevance of obtained data in guiding the selection of the most effective AB therapy. Read More

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November 2018
12 Reads

The Treatment of Genitoperineal Hidradenitis Suppurativa: A Review of the Literature.

Urology 2018 Nov 2. Epub 2018 Nov 2.

Department of Urology, The George Washington University School of Medicine and Health Sciences, Washington, DC.

Hidradenitis suppurativa is a chronic inflammatory condition affecting the axilla, genitals, perineum, and perianal regions. The pathophysiology of hidradenitis suppurativa is complex and requires a multidisciplinary approach to treatment involving medical and surgical management when indicated. We describe our multidisciplinary protocol for treatment, which includes rheumatology-monitored immunotherapy, medical management, wide surgical resection, wound care, and reconstruction. Read More

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November 2018
9 Reads

[Perineal prevention and protection in obstetrics: CNGOF Clinical Practice Guidelines (short version)].

Gynecol Obstet Fertil Senol 2018 Oct 31. Epub 2018 Oct 31.

Service de gynécologie-obstétrique et médecine de la reproduction, CHU de Poitiers, université de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France.

Introduction: The objective of these clinical practice guidelines was to analyse all of the interventions during pregnancy and childbirth that might prevent obstetric anal sphincter injuries (OASIS) and postnatal pelvic floor symptoms.

Material And Methods: These guidelines were developed in accordance with the methods prescribed by the French Health Authority (HAS).

Results: A prenatal clinical examination of the perineum is recommended for women with a history of Crohn's disease, OASIS, genital mutilation, or perianal lesions (professional consensus). Read More

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October 2018
1 Read

[Definition, epidemiology and risk factors of obstetric anal sphincter injuries: CNGOF Perineal Prevention and Protection in Obstetrics Guidelines].

Gynecol Obstet Fertil Senol 2018 Oct 29. Epub 2018 Oct 29.

Service de gynécologie-obstétrique, hôpitaux de Nantes, CHU Hôtel-Dieu, 38, boulevard Jean-Monnet, 44000 Nantes, France; Université de Nantes, 1, rue Gaston-Veil, 44000 Nantes, France.

Objectives: The aim of this review was to agree on a definition of the obstetric anal sphincter injuries (OASIS), to determine the prevalence and risk factors.

Methods: A comprehensive review of the literature on the obstetric anal sphincter injuries (OASIS), establishment of levels of evidence (NP), and grades of recommendation according to the methodology of the recommendations for clinical practice.

Results: To classify obstetric anal sphincter injuries (OASIS), we have used the WHO-RCOG classification, which lists 4 degrees of severity. Read More

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October 2018
5 Reads

MR Imaging of perianal fistulas; step-by-step guide for trainees - a video vignette (ESCP Trainee Video).

Authors:
D D E Zimmerman

Colorectal Dis 2018 Nov 1. Epub 2018 Nov 1.

Elisabeth - TweeSteden (ETZ) Hospital, Tilburg, The Netherlands.

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November 2018
1 Read

[Current diagnosis and treatment of sexually transmitted infections].

Urologe A 2018 Dec;57(12):1436-1444

Klinik für Urologie, Kinderurologie und Andrologie, Justus-Liebig-Universität Gießen, Rudolf-Buchheim-Str. 7, 35392, Gießen, Deutschland.

Background: In recent years, there has been an increasing incidence of sexually transmitted infections (STI), which in turn play a major role in urological clinical routine.

Objectives: Which STIs are relevant in urological clinical routine? What kind of recommendations for diagnosis and treatment exist?

Materials And Methods: Review of evidence-based recommendations from the literature, current guidelines of the European Association of Urology and the Robert-Koch-Institute.

Results: STIs can be differentiated into those that cause genital, anal, perianal or oral ulcers from STIs that cause urethritis, cervicitis, or urethral or vaginal discharge. Read More

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December 2018
1 Read

[Cheilitis granulomatosa revealing Crohn's disease].

Pan Afr Med J 2018 20;30:147. Epub 2018 Jun 20.

Service d'Hépato-gastroentérologie, Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohammed Ben Abdellah, Fès, Maroc.

Many disorders of the digestive tract cause cutaneous manifestations that may be an indication of an underlying condition; hence dermatologist plays a key role in recommending that the patient see a gastroenterologist. Conversely, gastroenterologist often sees patients with mucocutaneous lesions suggesting possible association with well-known digestive disorders. Chronic inflammatory bowel diseases are the typical example of this essential collaboration between the two specialities. Read More

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November 2018
1 Read