105 results match your criteria Perianal Granuloma

Microgranulomas at Diagnosis Are Associated With Need for Antitumor Necrosis Factor Escalation in Pediatric Crohn Disease.

J Pediatr Gastroenterol Nutr 2022 05 17;74(5):617-620. Epub 2022 Feb 17.

Department of Pathology, Massachusetts General Hospital, Boston, MA.

Introduction: Granulomas are a pathologic hallmark of Crohn disease (CD) although they are found in only a subset of patients. Well-formed granulomas are associated with an aggressive phenotype although it is unknown if microgranulomas confer a similar phenotype. This study sought to define the incidence of microgranulomas in pediatric CD and compare the clinical course with cases with granulomas and those without granulomatous inflammation. Read More

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Intralesional biologics for inflammatory dermatoses: A systematic review.

Dermatol Ther 2022 02 8;35(2):e15234. Epub 2021 Dec 8.

Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Biologic medications are systemic therapeutic options for inflammatory dermatoses. Local forms of administration are less well-studied. To provide a summary of intralesional (IL) administration of biologics for various non-malignant inflammatory dermatologic conditions reported in the literature. Read More

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February 2022

Changes in the clinical phenotype and behavior of pediatric luminal Crohn's disease at diagnosis in the last decade.

Dig Liver Dis 2022 Mar 27;54(3):343-351. Epub 2021 Oct 27.

CHU Sainte-Justine Research Center, 3175 Côte Sainte-Catherine, Montreal H3T 1C5, Quebec, Canada; Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada; Division of Gastroenterology, Department of Pediatrics, CHU Sainte-Justine, Montreal H3T 1C5, Quebec, Canada. Electronic address:

Background And Aims: The aims of this study were to describe the trends in the behavior of pediatric CD during the last decade and to describe the seasonal variation of disease presentation.

Methods: Patients under 18 years old and diagnosed between 2009 and 2019 were included. The clinical, endoscopic, histological, and laboratory data were collected from the medical records. Read More

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Outcomes of Pediatric Fistulising Perianal Crohn's Disease.

Turk J Gastroenterol 2021 03;32(3):240-247

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Marmara University School of Medicine, Istanbul, Turkey.

Background: Perianal disease is reported more widely in pediatric Crohn patients than in the past, and has been stated as an independent modifier of the disease behavior. In this study, we aimed to analyze the clinical characteristics and outcomes of fistulising perianal Crohn's disease (fpCD) in the pediatric age group.

Methods: A total number of 149 children with an established diagnosis of inflammatory bowel disease who have been diagnosed before 18 years of age and followed in our tertiary center were revised. Read More

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Application value of tissue tuberculosis antigen combined with Xpert MTB/RIF detection in differential diagnoses of intestinal tuberculosis and Crohn's disease.

BMC Infect Dis 2021 May 28;21(1):498. Epub 2021 May 28.

Tuberculosis Diagnosis and Treatment Center, Hangzhou Red Cross Hospital, Hangzhou, 310003, Zhejiang, China.

Background: The purpose of this study was to examine the value of Xpert MTB/RIF assay and detection of additional Mycobacterium tuberculosis complex (MTBC) species antigens from intestinal tissue samples in differentiating intestinal tuberculosis (ITB) from Crohn's disease (CD).

Methods: Several clinical specimens of intestinal tissue obtained by either endoscopic biopsy or surgical excision were used for mycobacteriologic solid cultures,Xpert MTB/RIF assays, immunohistochemistry, and histological examinations. Four antigens (38KDa, ESAT-6, MPT64, and Ag85 complex) of MTBC in the intestinal tissue were detected by immunohistochemical analysis. Read More

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Granulomas in Diagnostic Biopsies Associated With High Risk of Crohn's Complications-But May Be Preventable.

Inflamm Bowel Dis 2022 03;28(4):523-530

Division of Pediatric Gastroenterology, C.S. Mott Children's Hospital, Michigan Medicine, Ann Arbor, Michigan, United States.

Background: Granulomatous intestinal inflammation may be associated with aggressive Crohn's disease (CD) behavior. However, this has not been confirmed, and it is unknown if associated disease complications are preventable.

Methods: This is a retrospective cohort of patients younger than 21 years at CD diagnosis (November 1, 2005 to November 11, 2015). Read More

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Metastatic Crohn's disease: an underestimated entity.

J Dtsch Dermatol Ges 2021 07 7;19(7):973-982. Epub 2021 May 7.

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Cutaneous metastatic Crohn's disease (MCD) is a rare but challenging dermatologic manifestation of Crohn's disease. It is histologically defined as the presence of non-caseating granulomas at skin sites separated from and non-contiguous to the gastrointestinal tract. Cutaneous metastatic Crohn's disease should be distinguished from the much more frequent contiguous cutaneous manifestations of Crohn's disease that present at perianal or, less common, peristomal sites with direct extension from the intestine to the adjacent skin. Read More

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Dermoscopic Features of Giant Molluscum Contagiosum in a Patient with Acquired Immunodeficiency Syndrome.

Acta Dermatovenerol Croat 2020 Dec;28(7):233-235

Martyna Sławińska MD, PhD, Department of Dermatology, Venereology and Allergology Medical University of Gdańsk, Smoluchowskiego 17 Street, 80-214 Gdańsk;

Giant molluscum contagiosum (MC) is a peculiar variant of the disease with the presence of multiple or single lesions larger than 5 mm. In contrast to typical molluscum contagiosum, dermoscopic features of giant lesions have been poorly described, and none of the reports included multiple giant lesions in an immunocompromised patient. We present a patient with acquired immunodeficiency syndrome diagnosed with multiple giant molluscum contagiosum along with the dermoscopic features of this entity. Read More

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December 2020

Clinical features and monocyte/macrophage subsets characterization in granulomatous vs non-granulomatous Crohn's disease.

Scand J Gastroenterol 2020 Apr 14;55(4):442-448. Epub 2020 Apr 14.

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.

Granuloma, mainly composed of macrophages, is a histological feature of Crohn's disease (CD). However, its significance in CD has not been investigated adequately. Our study aims to address this issue by comparing the clinical manifestations and monocyte/macrophage subtypes between granulomatous and non-granulomatous CD. Read More

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Perianal Disease and Granulomas: Think Out of the Box….

GE Port J Gastroenterol 2020 Feb 1;27(2):119-123. Epub 2019 Oct 1.

Pediatric Gastroenterology Unit, Centro Hospitalar Universitário do São João, Porto, Portugal.

Background: Chronic granulomatous disease (CGD) is a primary immunodeficiency due to a malfunction of NADPH oxidase. It is characterized by recurrent and severe infections caused by catalase-positive microorganisms and autoinflammatory manifestations. Recently, there has been described an gene variant that causes a deficiency of p40, a subunit of NADPH oxidase. Read More

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February 2020

Bilateral inframammary pilonidal sinus: A case report with literature review.

Int J Surg Case Rep 2020 16;67:18-20. Epub 2020 Jan 16.

Iraqi Board For Medical Specialties, Sulaimani Center, Sulaymaniyah, Iraq.

Introduction: Pilonidal sinus (PNS) is a chronic inflammatory perianal disorder that rarely occurs outside sacrococcygeal region. The aim of this study is to report an extremely rare case of bilateral inframammary PNS with brief literature review.

Case Report: A 25-year-old female presented with a discharging sinuses in both inframammary region for two years. Read More

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January 2020

Perianal Histoplasmosis Presenting as a Mass Suspicious for Malignancy: A Case Report with Review of Gastrointestinal Manifestations of Histoplasmosis.

Am J Case Rep 2019 Nov 25;20:1740-1744. Epub 2019 Nov 25.

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.

BACKGROUND Disseminated histoplasmosis, a disease that can present years after exposure to the causative organism, may manifest in many diverse ways. Although the gastrointestinal tract is involved in most cases, the initial presentation occurring along the gastrointestinal tract, including the colon and rectum, is infrequent. CASE REPORT This case report describes a 66-year-old male patient who presented with an indurated painful perianal lesion that appeared highly suspicious for malignancy on imaging. Read More

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November 2019

British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.

Gut 2019 12 27;68(Suppl 3):s1-s106. Epub 2019 Sep 27.

University Hospital of Wales, Cardiff, UK.

Ulcerative colitis and Crohn's disease are the principal forms of inflammatory bowel disease. Both represent chronic inflammation of the gastrointestinal tract, which displays heterogeneity in inflammatory and symptomatic burden between patients and within individuals over time. Optimal management relies on understanding and tailoring evidence-based interventions by clinicians in partnership with patients. Read More

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December 2019

Clinical significance of granulomas in Crohn's disease: A systematic review and meta-analysis.

J Gastroenterol Hepatol 2020 Mar 26;35(3):364-373. Epub 2019 Nov 26.

Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Background And Aim: Epithelioid granuloma is one hallmark used to histologically diagnose Crohn's disease (CD). However, the clinical significance of granulomas in CD is unclear. Therefore, we performed a meta-analysis to compare the clinical features with CD according to the presence of granulomas. Read More

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Miscellaneous Perianal Afflictions.

Clin Colon Rectal Surg 2019 Sep 22;32(5):394-402. Epub 2019 Aug 22.

Department of Surgery, ABC Medical Center, Mexico City, Mexico.

This article provides an overview of hidradenitis suppurativa, lichen planus, lichen sclerosis, calcinosis cuti, pyogenic granuloma, intertrigo, and seborrheic keratosis. This article also focuses on recognition and management of these pleomorphic afflictions of the perianal region. Read More

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September 2019

[Anogenital granulomatosis as extradigestive Crohn disease: Efficiency of adalimumab therapy].

Rev Med Interne 2019 Oct 23;40(10):677-679. Epub 2019 Aug 23.

Service de dermatologie et allergologie, CHU Besançon, 3, boulevard Fleming, 25000 Besançon, France.

Introduction: Anogenital granulomatosis is a rare disease which is actually considered as a metastatic lesion of Crohn disease (CD).

Observation: A 53-year-old woman presented with intermittent vulvar and anoperineal lesions since adolescence, seeping and painful during sexual intercourse. We observed an infiltrative and asymmetric oedema of labia majora, perianal oedematous vegetative pseudo-marisca, and groin fold and perianal linear "knife-like" ulcerations. Read More

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October 2019

Malacoplakia of the skin: overview of a rare clinical entity.

Dermatol Online J 2019 Jun 15;25(6). Epub 2019 Jun 15.

Department of Dermatology, University General Hospital of Patras.

Background: Malacoplakia is a rare acquired, infection-related granulomatous disorder, that may affect many systems, but typically occurs in the urinary tract. Cutaneous involvement is less prevalent, and most commonly presents with a perianal or genital region localization. Cutaneous malacoplakia is believed to be caused by an acquired bactericidal defect of macrophages in the setting of chronic infections and immunocompromised states. Read More

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Differentiating Crohn's disease from intestinal tuberculosis.

World J Gastroenterol 2019 Jan;25(4):418-432

Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi 110029, India.

Differentiating Crohn's disease (CD) and intestinal tuberculosis (ITB) has remained a dilemma for most of the clinicians in the developing world, which are endemic for ITB, and where the disease burden of inflammatory bowel disease is on the rise. Although, there are certain clinical (diarrhea/hematochezia/perianal disease common in CD; fever/night sweats common in ITB), endoscopic (longitudinal/aphthous ulcers common in CD; transverse ulcers/patulous ileocaecal valve common in ITB), histologic (caseating/confluent/large granuloma common in ITB; microgranuloma common in CD), microbiologic (positive stain/culture for acid fast-bacillus in ITB), radiologic (long segment involvement/comb sign/skip lesions common in CD; necrotic lymph node/contiguous ileocaecal involvement common in ITB), and serologic differences between CD and ITB, the only exclusive features are caseation necrosis on biopsy, positive smear for acid-fast bacillus (AFB) and/or AFB culture, and necrotic lymph node on cross-sectional imaging in ITB. However, these exclusive features are limited by poor sensitivity, and this has led to the development of multiple multi-parametric predictive models. Read More

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January 2019

Cutaneous Crohn disease without gastrointestinal involvement in a 9-year-old boy.

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

Cutaneous Crohn disease (CCD) is a rare dermatologic manifestation of Crohn disease and is defined as noncaseating, granulomatous skin lesions noncontiguous with the gastrointestinal tract. It most commonly affects the skin of the legs, although genital CCD is the most common presentation in children. Diagnosis of CCD is made by a combination of clinical and histopathological findings. Read More

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Hemolytic uremic syndrome: differential diagnosis with the onset of inflammatory bowel diseases.

Acta Biomed 2018 12 17;89(9-S):153-157. Epub 2018 Dec 17.

Pediatric Emergency Unit, University Hospital of Parma, Maternal and Infant Department, Parma, Italy.

Background: Shiga-toxin Escherichia coli productor (STEC) provokes frequently an important intestinal damage that may be considered in differential diagnosis with the onset of Inflammatory Bowel Disease (IBD). The aim of this work is to review in the current literature about Hemolytic Uremic Syndrome (HUS) and IBD symptoms at the onset, comparing the clinical presentation and symptoms, as the timing of diagnosis and of the correct treatment of both these conditions is a fundamental prognostic factor. A focus is made about the association between typical or atypical HUS and IBD and a possible renal involvement in patient with IBD (IgA-nephropathy). Read More

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December 2018

Painful nonhealing vulvar and perianal erosions.

Cutis 2018 06;101(6):E8-E10

Department of Dermatology, Baylor College of Medicine, Houston, Texas, USA.

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Expression Profiling of and Genes through RT-qPCR in Different Cancer Types of .

Iran J Biotechnol 2017 27;15(3):186-193. Epub 2017 Sep 27.

Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Outfall Road, Lahore 54000, Pakistan.

Diagnostic molecular marker studies are in vogue to have insight of most prevalent animal diseases including cancer. Gene expression profiling of pro and anti-apoptotic genes was conducted in dog Lymphoma, CTVT, SCC, granuloma, perianal adenocarcinoma and mammary tumors. Cancerous tissues of 21 affected animals were obtained. Read More

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September 2017

Differentiating Crohn's disease from intestinal tuberculosis at presentation in patients with tissue granulomas.

S Afr Med J 2018 Apr 25;108(5):399-402. Epub 2018 Apr 25.

Division of Gastroenterology, Department of Medicine, Groote Schuur Hospital and Faculty of Health Sciences, University of Cape Town, South Africa.

Background: Overlapping clinical, endoscopic, radiographic and histological features, coupled with poor microbiological yield, make differentiating Crohn's disease (CD) from intestinal tuberculosis (ITB) challenging. Granulomas are present in both diseases; in CD they predict the need for immunosuppressive therapy that requires ITB to be excluded before initiation.

Objectives: To compare granuloma-positive CD and ITB, to identify factors that may aid in diagnosis. Read More

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Genital Granulomatosis in Male and Female Patients With Crohn's Disease: Clinical Presentation and Treatment Outcomes.

J Crohns Colitis 2018 Jan;12(2):197-203

Hospital Universitari Germans Trias i Pujol, Badalona, and CIBEREHD, Madrid, Spain.

Background: Genital granulomatosis [GG] is a metastatic form of Crohn's disease [CD], characterised by granulomatous inflammation of the genital skin without contact with the gastrointestinal tract. Little is known about GG, as most publications are case reports or small series, and only sporadic in male cases.

Methods And Aims: Cases of GG were retrospectively collected through the Collaborative Network For Exceptionally Rare case reports project of the European Crohn's and Colitis Organisation. Read More

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January 2018

Topical Imiquimod is an Effective and Safe Drug for Molluscum Contagiosum in Children.

Acta Dermatovenerol Croat 2017 Jul;25(2):164-166

Efstathia Pasmatzi, MD, Department of Dermatology School of Medicine University of Patras, 26504 Rio-Patras, Greece;

Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usually occurs in young children, sexually active adults, and immunocompromised individuals. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or multiple papules, measuring 2-6 mm in diameter with a central umbilication that occur on the skin and the mucous membranes. Read More

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Association of granulomas in mesenteric lymph nodes in Crohn's disease with younger age and transmural inflammation.

J Gastroenterol Hepatol 2017 Aug;32(8):1463-1468

Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Background And Aims: Mesenteric lymph nodes were usually removed during bowel resection surgery for Crohn's disease (CD). Mesenteric lymph node (MLN) granuloma predicted postoperative disease recurrence in patients with CD after ileocolic resection (ICR). This study was aimed to identify factors associated with MLN granulomas in a cohort of CD patients who underwent ICR. Read More

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Meta-Analytic Bayesian Model For Differentiating Intestinal Tuberculosis from Crohn's Disease.

Am J Gastroenterol 2017 03 3;112(3):415-427. Epub 2017 Jan 3.

Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.

Objectives: Distinguishing intestinal tuberculosis (ITB) from Crohn's disease (CD) is difficult, although studies have reported clinical, endoscopic, imaging, and laboratory findings that help to differentiate these two diseases. We aimed to produce estimates of the predictive power of these findings and construct a comprehensive model to predict the probability of ITB vs. CD. Read More

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Factors affecting the incidence of early endoscopic recurrence after ileocolonic resection for Crohn's disease: a multicentre observational study.

Colorectal Dis 2017 Jan;19(1):O39-O45

IBD Centre, Yokkaichi Hazu Medical Centre, Yokkaichi, Japan.

Aim: Early endoscopic recurrence is frequently observed in patients following resection for Crohn's disease (CD). However, factors affecting the incidence of an early postoperative endoscopic recurrence (EPER) have not been fully determined. The aim of this study was to evaluate risk factors for EPER after ileocolonic resection for CD. Read More

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January 2017

Painful Perianal Papules in a Middle-Aged Woman.

JAMA Dermatol 2016 07;152(7):833-5

Department of Dermatology, University of Utah, Salt Lake City.

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