96 results match your criteria Perianal Granuloma


Clinical features and monocyte/macrophage subsets characterization in granulomatous vs non-granulomatous Crohn's disease.

Scand J Gastroenterol 2020 Apr 14;55(4):442-448. Epub 2020 Apr 14.

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.

Granuloma, mainly composed of macrophages, is a histological feature of Crohn's disease (CD). However, its significance in CD has not been investigated adequately. Our study aims to address this issue by comparing the clinical manifestations and monocyte/macrophage subtypes between granulomatous and non-granulomatous CD. Read More

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http://dx.doi.org/10.1080/00365521.2020.1748222DOI Listing

Perianal Disease and Granulomas: Think Out of the Box….

GE Port J Gastroenterol 2020 Feb 1;27(2):119-123. Epub 2019 Oct 1.

Pediatric Gastroenterology Unit, Centro Hospitalar Universitário do São João, Porto, Portugal.

Background: Chronic granulomatous disease (CGD) is a primary immunodeficiency due to a malfunction of NADPH oxidase. It is characterized by recurrent and severe infections caused by catalase-positive microorganisms and autoinflammatory manifestations. Recently, there has been described an gene variant that causes a deficiency of p40, a subunit of NADPH oxidase. Read More

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http://dx.doi.org/10.1159/000502358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113594PMC
February 2020

Bilateral inframammary pilonidal sinus: A case report with literature review.

Int J Surg Case Rep 2020 16;67:18-20. Epub 2020 Jan 16.

Iraqi Board For Medical Specialties, Sulaimani Center, Sulaymaniyah, Iraq.

Introduction: Pilonidal sinus (PNS) is a chronic inflammatory perianal disorder that rarely occurs outside sacrococcygeal region. The aim of this study is to report an extremely rare case of bilateral inframammary PNS with brief literature review.

Case Report: A 25-year-old female presented with a discharging sinuses in both inframammary region for two years. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076278PMC
January 2020

Perianal Histoplasmosis Presenting as a Mass Suspicious for Malignancy: A Case Report with Review of Gastrointestinal Manifestations of Histoplasmosis.

Am J Case Rep 2019 Nov 25;20:1740-1744. Epub 2019 Nov 25.

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.

BACKGROUND Disseminated histoplasmosis, a disease that can present years after exposure to the causative organism, may manifest in many diverse ways. Although the gastrointestinal tract is involved in most cases, the initial presentation occurring along the gastrointestinal tract, including the colon and rectum, is infrequent. CASE REPORT This case report describes a 66-year-old male patient who presented with an indurated painful perianal lesion that appeared highly suspicious for malignancy on imaging. Read More

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http://dx.doi.org/10.12659/AJCR.918220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892389PMC
November 2019

British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.

Gut 2019 12 27;68(Suppl 3):s1-s106. Epub 2019 Sep 27.

University Hospital of Wales, Cardiff, UK.

Ulcerative colitis and Crohn's disease are the principal forms of inflammatory bowel disease. Both represent chronic inflammation of the gastrointestinal tract, which displays heterogeneity in inflammatory and symptomatic burden between patients and within individuals over time. Optimal management relies on understanding and tailoring evidence-based interventions by clinicians in partnership with patients. Read More

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http://dx.doi.org/10.1136/gutjnl-2019-318484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872448PMC
December 2019
9 Reads
14.660 Impact Factor

Clinical significance of granulomas in Crohn's disease: A systematic review and meta-analysis.

J Gastroenterol Hepatol 2020 Mar 26;35(3):364-373. Epub 2019 Nov 26.

Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Background And Aim: Epithelioid granuloma is one hallmark used to histologically diagnose Crohn's disease (CD). However, the clinical significance of granulomas in CD is unclear. Therefore, we performed a meta-analysis to compare the clinical features with CD according to the presence of granulomas. Read More

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http://dx.doi.org/10.1111/jgh.14849DOI Listing
March 2020
3 Reads
3.504 Impact Factor

Miscellaneous Perianal Afflictions.

Clin Colon Rectal Surg 2019 Sep 22;32(5):394-402. Epub 2019 Aug 22.

Department of Surgery, ABC Medical Center, Mexico City, Mexico.

This article provides an overview of hidradenitis suppurativa, lichen planus, lichen sclerosis, calcinosis cuti, pyogenic granuloma, intertrigo, and seborrheic keratosis. This article also focuses on recognition and management of these pleomorphic afflictions of the perianal region. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1687836
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http://dx.doi.org/10.1055/s-0039-1687836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731119PMC
September 2019
11 Reads

[Anogenital granulomatosis as extradigestive Crohn disease: Efficiency of adalimumab therapy].

Rev Med Interne 2019 Oct 23;40(10):677-679. Epub 2019 Aug 23.

Service de dermatologie et allergologie, CHU Besançon, 3, boulevard Fleming, 25000 Besançon, France.

Introduction: Anogenital granulomatosis is a rare disease which is actually considered as a metastatic lesion of Crohn disease (CD).

Observation: A 53-year-old woman presented with intermittent vulvar and anoperineal lesions since adolescence, seeping and painful during sexual intercourse. We observed an infiltrative and asymmetric oedema of labia majora, perianal oedematous vegetative pseudo-marisca, and groin fold and perianal linear "knife-like" ulcerations. Read More

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http://dx.doi.org/10.1016/j.revmed.2019.05.014DOI Listing
October 2019
2 Reads

Malacoplakia of the skin: overview of a rare clinical entity.

Dermatol Online J 2019 Jun 15;25(6). Epub 2019 Jun 15.

Department of Dermatology, University General Hospital of Patras.

Background: Malacoplakia is a rare acquired, infection-related granulomatous disorder, that may affect many systems, but typically occurs in the urinary tract. Cutaneous involvement is less prevalent, and most commonly presents with a perianal or genital region localization. Cutaneous malacoplakia is believed to be caused by an acquired bactericidal defect of macrophages in the setting of chronic infections and immunocompromised states. Read More

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June 2019
5 Reads

Differentiating Crohn's disease from intestinal tuberculosis.

World J Gastroenterol 2019 Jan;25(4):418-432

Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi 110029, India.

Differentiating Crohn's disease (CD) and intestinal tuberculosis (ITB) has remained a dilemma for most of the clinicians in the developing world, which are endemic for ITB, and where the disease burden of inflammatory bowel disease is on the rise. Although, there are certain clinical (diarrhea/hematochezia/perianal disease common in CD; fever/night sweats common in ITB), endoscopic (longitudinal/aphthous ulcers common in CD; transverse ulcers/patulous ileocaecal valve common in ITB), histologic (caseating/confluent/large granuloma common in ITB; microgranuloma common in CD), microbiologic (positive stain/culture for acid fast-bacillus in ITB), radiologic (long segment involvement/comb sign/skip lesions common in CD; necrotic lymph node/contiguous ileocaecal involvement common in ITB), and serologic differences between CD and ITB, the only exclusive features are caseation necrosis on biopsy, positive smear for acid-fast bacillus (AFB) and/or AFB culture, and necrotic lymph node on cross-sectional imaging in ITB. However, these exclusive features are limited by poor sensitivity, and this has led to the development of multiple multi-parametric predictive models. Read More

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http://dx.doi.org/10.3748/wjg.v25.i4.418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350172PMC
January 2019
33 Reads
2.369 Impact Factor

Cutaneous Crohn disease without gastrointestinal involvement in a 9-year-old boy.

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

Cutaneous Crohn disease (CCD) is a rare dermatologic manifestation of Crohn disease and is defined as noncaseating, granulomatous skin lesions noncontiguous with the gastrointestinal tract. It most commonly affects the skin of the legs, although genital CCD is the most common presentation in children. Diagnosis of CCD is made by a combination of clinical and histopathological findings. Read More

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August 2018
34 Reads

Hemolytic uremic syndrome: differential diagnosis with the onset of inflammatory bowel diseases.

Acta Biomed 2018 12 17;89(9-S):153-157. Epub 2018 Dec 17.

Pediatric Emergency Unit, University Hospital of Parma, Maternal and Infant Department, Parma, Italy.

Background: Shiga-toxin Escherichia coli productor (STEC) provokes frequently an important intestinal damage that may be considered in differential diagnosis with the onset of Inflammatory Bowel Disease (IBD). The aim of this work is to review in the current literature about Hemolytic Uremic Syndrome (HUS) and IBD symptoms at the onset, comparing the clinical presentation and symptoms, as the timing of diagnosis and of the correct treatment of both these conditions is a fundamental prognostic factor. A focus is made about the association between typical or atypical HUS and IBD and a possible renal involvement in patient with IBD (IgA-nephropathy). Read More

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http://dx.doi.org/10.23750/abm.v89i9-S.7911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502198PMC
December 2018
40 Reads

Painful nonhealing vulvar and perianal erosions.

Cutis 2018 06;101(6):E8-E10

Department of Dermatology, Baylor College of Medicine, Houston, Texas, USA.

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June 2018
6 Reads

Expression Profiling of and Genes through RT-qPCR in Different Cancer Types of .

Iran J Biotechnol 2017 27;15(3):186-193. Epub 2017 Sep 27.

Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Outfall Road, Lahore 54000, Pakistan.

Diagnostic molecular marker studies are in vogue to have insight of most prevalent animal diseases including cancer. Gene expression profiling of pro and anti-apoptotic genes was conducted in dog Lymphoma, CTVT, SCC, granuloma, perianal adenocarcinoma and mammary tumors. Cancerous tissues of 21 affected animals were obtained. Read More

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http://dx.doi.org/10.15171/ijb.1505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811066PMC
September 2017
15 Reads

Differentiating Crohn's disease from intestinal tuberculosis at presentation in patients with tissue granulomas.

S Afr Med J 2018 Apr 25;108(5):399-402. Epub 2018 Apr 25.

Division of Gastroenterology, Department of Medicine, Groote Schuur Hospital and Faculty of Health Sciences, University of Cape Town, South Africa.

Background: Overlapping clinical, endoscopic, radiographic and histological features, coupled with poor microbiological yield, make differentiating Crohn's disease (CD) from intestinal tuberculosis (ITB) challenging. Granulomas are present in both diseases; in CD they predict the need for immunosuppressive therapy that requires ITB to be excluded before initiation.

Objectives: To compare granuloma-positive CD and ITB, to identify factors that may aid in diagnosis. Read More

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http://dx.doi.org/10.7196/SAMJ.2018.v108i5.13108DOI Listing
April 2018
4 Reads

Genital Granulomatosis in Male and Female Patients With Crohn's Disease: Clinical Presentation and Treatment Outcomes.

J Crohns Colitis 2018 Jan;12(2):197-203

Hospital Universitari Germans Trias i Pujol, Badalona, and CIBEREHD, Madrid, Spain.

Background: Genital granulomatosis [GG] is a metastatic form of Crohn's disease [CD], characterised by granulomatous inflammation of the genital skin without contact with the gastrointestinal tract. Little is known about GG, as most publications are case reports or small series, and only sporadic in male cases.

Methods And Aims: Cases of GG were retrospectively collected through the Collaborative Network For Exceptionally Rare case reports project of the European Crohn's and Colitis Organisation. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjx131DOI Listing
January 2018
41 Reads

Topical Imiquimod is an Effective and Safe Drug for Molluscum Contagiosum in Children.

Acta Dermatovenerol Croat 2017 Jul;25(2):164-166

Efstathia Pasmatzi, MD, Department of Dermatology School of Medicine University of Patras, 26504 Rio-Patras, Greece;

Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usually occurs in young children, sexually active adults, and immunocompromised individuals. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or multiple papules, measuring 2-6 mm in diameter with a central umbilication that occur on the skin and the mucous membranes. Read More

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July 2017
39 Reads

Association of granulomas in mesenteric lymph nodes in Crohn's disease with younger age and transmural inflammation.

J Gastroenterol Hepatol 2017 Aug;32(8):1463-1468

Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Background And Aims: Mesenteric lymph nodes were usually removed during bowel resection surgery for Crohn's disease (CD). Mesenteric lymph node (MLN) granuloma predicted postoperative disease recurrence in patients with CD after ileocolic resection (ICR). This study was aimed to identify factors associated with MLN granulomas in a cohort of CD patients who underwent ICR. Read More

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http://dx.doi.org/10.1111/jgh.13735DOI Listing
August 2017
84 Reads

Meta-Analytic Bayesian Model For Differentiating Intestinal Tuberculosis from Crohn's Disease.

Am J Gastroenterol 2017 03 3;112(3):415-427. Epub 2017 Jan 3.

Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.

Objectives: Distinguishing intestinal tuberculosis (ITB) from Crohn's disease (CD) is difficult, although studies have reported clinical, endoscopic, imaging, and laboratory findings that help to differentiate these two diseases. We aimed to produce estimates of the predictive power of these findings and construct a comprehensive model to predict the probability of ITB vs. CD. Read More

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http://dx.doi.org/10.1038/ajg.2016.529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551982PMC
March 2017
65 Reads

Factors affecting the incidence of early endoscopic recurrence after ileocolonic resection for Crohn's disease: a multicentre observational study.

Colorectal Dis 2017 Jan;19(1):O39-O45

IBD Centre, Yokkaichi Hazu Medical Centre, Yokkaichi, Japan.

Aim: Early endoscopic recurrence is frequently observed in patients following resection for Crohn's disease (CD). However, factors affecting the incidence of an early postoperative endoscopic recurrence (EPER) have not been fully determined. The aim of this study was to evaluate risk factors for EPER after ileocolonic resection for CD. Read More

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http://dx.doi.org/10.1111/codi.13581DOI Listing
January 2017
19 Reads

Painful Perianal Papules in a Middle-Aged Woman.

JAMA Dermatol 2016 07;152(7):833-5

Department of Dermatology, University of Utah, Salt Lake City.

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http://dx.doi.org/10.1001/jamadermatol.2016.0143DOI Listing
July 2016
5 Reads

Gastric lesions in patients with Crohn's disease in Korea: a multicenter study.

Intest Res 2016 Jan 26;14(1):60-8. Epub 2016 Jan 26.

Department of Internal Medicine, Hanyang University College of Medicine, Hanyang University Guri Hospital, Guri, Korea.

Background/aims: Gastric pathology and Helicobacter pylori (H. pylori) infection among Asian patients with Crohn's disease (CD) are still unclear. We evaluated gastric histologic features and frequency of H. Read More

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http://dx.doi.org/10.5217/ir.2016.14.1.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754524PMC
January 2016
55 Reads

Does Crohn's Disease with Concomitant Orofacial Granulomatosis Represent a Distinctive Disease Subtype?

Inflamm Bowel Dis 2016 May;22(5):1071-7

*Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; †Department of Pediatrics, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; ‡Department of Infectious Medicine, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; §Department of Women's and Children's Health, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden; and ‖Paediatric Dentistry, Eastman Institute, Public Dental Health, Stockholm, Sweden.

Background: Although orofacial granulomatosis (OFG) may present as a separate clinical entity, it often seems in conjunction with various systemic diseases, of which Crohn's disease (CD) is one of the most common. The aim of this study was to investigate whether CD with concomitant OFG represents a distinctive disease subtype.

Methods: Twenty-one patients with CD and concomitant OFG (CD+OFG group) were included in the study. Read More

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http://dx.doi.org/10.1097/MIB.0000000000000670DOI Listing
May 2016
50 Reads

Clinicohistological Profile of Cutaneous Tuberculosis in Central Nepal.

Authors:
M Mathur S N Pandey

Kathmandu Univ Med J (KUMJ) 2014 Oct-Dec;12(48):238-41

Department of Dermatology College of Medical Sciences- Teaching Hospital Bharatpur, Chitwan, Nepal.

Background: There are few studies on cutaneous tuberculosis in Nepal.

Objective: To analyse the epidemiological, clinical and histological patterns of cutaneous TB over the past 5 years.

Method: Patients with cutaneous tuberculosis diagnosed from January 2010 to December 2014 at College of Medical Sciences, Chitwan, Nepal were included in the study. Read More

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http://www.kumj.com.np/issue/48/238-241.pdf
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http://dx.doi.org/10.3126/kumj.v12i4.13727DOI Listing
March 2016
11 Reads

The analysis of clinico-pathologic characteristics in patients who underwent surgery due to stricturing and non-perineal fistulizing forms of Crohn's disease: a retrospective cohort study.

Int J Surg 2015 Mar 31;15:49-54. Epub 2015 Jan 31.

Sakarya University, Faculty of Medicine, Department of General Surgery, Sakarya, Turkey.

Background: The diagnosis of Crohn's disease is based mainly on the patient's history and clinical examination and supported by serologic, radiologic, endoscopic, and histologic findings.

Aims: The main purpose of the present study was to evaluate in a retrospective manner the clinico-pathological characteristics of patients who underwent surgery due to stricturing or non perineal fistulizing Crohn's disease.

Material And Methods: Between January 2007 and June 2012, 75 patients who were operated on for stricturing and non-perineal fistulizing forms of Crohn's disease were analyzed according to their clinico-pathological characteristics. Read More

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http://dx.doi.org/10.1016/j.ijsu.2015.01.029DOI Listing
March 2015
22 Reads

Giant intraoral condyloma accuminatum lesion coexisting with genital condyloma.

Pak J Med Sci 2014 Sep;30(5):1143-6

Zafer Kucukodaci, Department of Pathology, Gumussuyu Military Hospital, Istanbul, Turkey.

The condyloma acuminatum (venereal wart) is a benign epithelial proliferation that occurs most frequently on the mucous membranes of the perianal and genital areas of men and women. The transmissible etiological agents of this lesion are papillomaviruses. In some rare instances these lesion can also be found in the oral cavity. Read More

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http://dx.doi.org/10.12669/pjms.305.5322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163250PMC
September 2014
49 Reads

Case for diagnosis. Hashimoto-Pritzker disease.

An Bras Dermatol 2013 Nov-Dec;88(6):1001-3

Pediatric Dermatology Service, Federal University of Minas Gerais, Hospital das Clínicas, Belo HorizonteMG, Brazil, Specialist in Dermatology and Pediatrics. Master in Dermatology, Federal University of Minas Gerais (UFMG). Medical Clinic of Pediatric Dermatology Service, Hospital das Clínicas, Federal University of Minas Gerais (HC-UFMG) - Belo Horizonte (MG), Brazil.

Langerhans cell histiocytosis is a rare, clinically heterogeneous disease. Since there is considerable clinical overlap among the four described variants (Hand-Schüller-Christian, eosinophilic granuloma, Letterer-Siwe and Hashimoto-Pritzker), the concept of spectral disease applies to this entity. The Hashimoto-Pritzker variant was first described in 1973. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20132451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900360PMC
September 2014
22 Reads

An illustrative case report of secondary syphilis with alopecia syphilitica, perianal condyloma latum, and granuloma annulare-like lesions.

Cutis 2013 Nov;92(5):E13-5

Department of Dermatology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, China 221006.

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November 2013
69 Reads

Cutaneous leukocytoclastic vasculitis revealing multifocal tuberculosis.

Int J Mycobacteriol 2013 Dec 17;2(4):230-2. Epub 2013 Aug 17.

Dermatological Department, Hassan II University Hospital, Fes, Morocco.

Cutaneous leukocytoclastic vasculitis (CLV) is an inflammatory vascular disorder rarely reported to be associated with tuberculosis. The following report describes the case of a young man with multifocal tuberculosis revealed by CLV. Diagnosis was confirmed by the presence of tuberculoid granuloma with caseous necrosis on pleural and perianal biopsy, and a rapid improvement in anti-tuberculous quadritherapy. Read More

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http://dx.doi.org/10.1016/j.ijmyco.2013.07.004DOI Listing
December 2013
14 Reads

Evaluation of diagnostic criteria for Crohn's disease in Japan.

J Gastroenterol 2014 Jan 3;49(1):93-9. Epub 2013 Apr 3.

Department of Gastroenterology, Fukuoka University Chikushi Hospital, 1-1-1 Zokumyoin, Chikushino, Fukuoka, 818-8502, Japan,

Background: In Japan, Crohn's disease (CD) is diagnosed according to a single, well-established set of diagnostic criteria. However, no nationwide attempt has been made to determine which specific criteria within these diagnostic criteria are used to make diagnoses.

Methods: A questionnaire-based survey was conducted of patients given a definitive or suspected diagnosis of CD before January 2011 according to the Japanese Diagnostic Criteria for Crohn's Disease. Read More

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http://dx.doi.org/10.1007/s00535-013-0798-xDOI Listing
January 2014
8 Reads

Perianal pulse granuloma.

Int J Surg Pathol 2013 Feb 17;21(1):45. Epub 2012 Oct 17.

Azienda Ospedaliera Sant'Anna, Como, Italy.

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http://journals.sagepub.com/doi/10.1177/1066896912458830
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http://dx.doi.org/10.1177/1066896912458830DOI Listing
February 2013
12 Reads

[Vulvar papulpustules and perianal ulcerations].

Ann Pathol 2012 Aug 23;32(4):280-2. Epub 2012 May 23.

Service de dermatologie, hôpital Habib Thameur de Tunis, 8, rue Ali-Ben-Ayed, Montfleury, 1008 Tunis, Tunisie.

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http://dx.doi.org/10.1016/j.annpat.2012.02.017DOI Listing
August 2012
13 Reads
0.291 Impact Factor

Hypertrophic donavanosis in a young pregnant woman.

J Pediatr Adolesc Gynecol 2012 Aug;25(4):e81-3

Department of Mother and Infant Sciences, University of Milan, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Donovanosis is a chronic bacterial illness, progressive and indolent, which normally attacks the skin and mucous membranes in the genital and perigenital regions.

Case: An 18-year-old pregnant female presented with large, hypertrophic lesions in the ano-genital region. HIV serology was negative. Read More

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http://dx.doi.org/10.1016/j.jpag.2011.10.002DOI Listing
August 2012
11 Reads

Surgical outcome of ileal pouch-anal anastomosis when used intentionally for well-defined Crohn's disease.

Inflamm Bowel Dis 2013 Jan;19(1):30-6

Division of Colon and Rectal Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Background: Crohn's disease (CD) is considered a contraindication to ileal pouch--anal anastomosis (IPAA). In this study, we compare outcomes of CD and ulcerative colitis (UC) patients undergoing IPAA.

Methods: Patients were considered to have CD before surgery based on a history of small bowel disease, perianal disease, noncrypt-associated granuloma, or pretreatment skip colonic lesions. Read More

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http://dx.doi.org/10.1002/ibd.22955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457327PMC
January 2013
27 Reads
4.464 Impact Factor

Biological immunomodulators improve the healing rate in surgically treated perianal Crohn's fistulas.

Colorectal Dis 2012 Oct;14(10):1217-23

Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

Aim: The role of biological therapy in perianal fistulas associated with Crohn's disease (CD) is uncertain as available data are confused and conflicting. In order to provide some clarity to the issue we have examined a large cohort of patients with perianal fistulas and CD and stratified them according to use of biological agents.

Method: Patients with perianal Crohn's fistulas treated between June 1999 and June 2009 were stratified according to use of biological agents and outcome was examined. Read More

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http://dx.doi.org/10.1111/j.1463-1318.2012.02944.xDOI Listing
October 2012
10 Reads

[To grow up with Crohn's disease].

Orv Hetil 2011 Apr;152(14):546-54

Fővárosi Önkormányzat Heim Pál Gyermekkórháza Gasztroenterológiai és Nefrológiai Osztály, Budapest.

Objective: To assess the characteristics and course of childhood-onset Crohn's disease among Hungarian patients.

Methods: Records of 81 patients admitted between 1984 and 2006 and treated at least for one year until the 18th year of age were reviewed.

Results: There was a 62% male dominance and a rate of 12. Read More

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http://dx.doi.org/10.1556/OH.2011.29074DOI Listing
April 2011
7 Reads

Significance of esophageal Crohn disease in children.

J Pediatr Gastroenterol Nutr 2011 Mar;52(3):291-4

Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Background And Aim: Esophageal Crohn disease (ECD) is more common than it was originally thought to be. Only limited information, however, is available regarding its significance and effect on clinical course in the pediatric population. The aim of the study was to determine the prevalence of ECD in our patient population and compare clinical features and severity of disease among patients with ECD and nonesophageal Crohn disease (NECD). Read More

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http://dx.doi.org/10.1097/MPG.0b013e3181ec21b5DOI Listing
March 2011
7 Reads

Beware the perianal granuloma! A case report.

Acta Cytol 2010 Sep-Oct;54(5 Suppl):1031-4

Department of Pathology, Kasturba Medical College, Light House Hill Road, Mangalore 575001, Karnataka, India.

Background: Crohn's disease (CD) can often present initially with extraintestinal manifestations and/or perianal disease. Cytology of such a lesion helps arrive at the diagnosis.

Case: A 27-year-old woman presented with recurrent, painful, discharging perianal lesions. Read More

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December 2010
10 Reads

Granulomas in Crohn's disease: does progression through the bowel layers affect presentation or predict recurrence?

Colorectal Dis 2011 Oct;13(10):1142-7

Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, Florida 33331, USA.

Aim: The aim of the study was to correlate the presence and pattern of distribution of granulomas in resected specimens to clinical characteristics and outcome in patients undergoing surgery for Crohn's disease.

Method: Patients with Crohn's disease who underwent surgical resection between 2001 and 2007 were identified. Pathology slides were reviewed for the presence, number and location of granulomas in four representative slides from each specimen. Read More

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http://dx.doi.org/10.1111/j.1463-1318.2010.02421.xDOI Listing
October 2011
20 Reads

Crohn's disease in India: a multicenter study from a country where tuberculosis is endemic.

Dig Dis Sci 2009 May 4;54(5):1099-107. Epub 2008 Sep 4.

Division of Gastroenterology, School of Digestive and Liver Diseases, Institute of Post-Graduate Medical Education & Research, Kolkata, India.

Although Crohn's disease is thought to be rare and intestinal tuberculosis common in India, Crohn's disease is being reported more often. However, there is a lack of systematic study on Crohn's disease from India. In this analysis of data from three inflammatory bowel disease clinics (two in northern India and one in eastern India), criteria for Crohn's disease were applied retrospectively: (1) World Health Organization (WHO) criteria; or (2) compatible histology (European Crohn's and Colitis Organization) or failure of response to 4-8 weeks of anti-tuberculosis therapy (Asia-Pacific guidelines); or (3) compatible macroscopic, radiologic, colonoscopic features (European Crohn's and Colitis Organization). Read More

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http://dx.doi.org/10.1007/s10620-008-0469-6DOI Listing
May 2009
15 Reads

Jacquet erosive diaper dermatitis: a complication of adult urinary incontinence.

Cutis 2008 Jul;82(1):72-4

Baylor College of Medicine, Houston, TX, USA.

Jacquet erosive diaper dermatitis is typically described as a severe irritant dermatitis of the perianal region. However, Jacquet erosive diaper dermatitis, perianal pseudoverrucous papules and nodules, and granuloma gluteale infantum/ adultorum have been regarded as discrete entities or all part of the same clinical spectrum, representing the result of chronic, severe, irritant contact dermatitis. We present a case of Jacquet erosive diaper dermatitis and a discussion of the clinical spectrum of diseases to which it belongs. Read More

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July 2008
29 Reads

Metastatic Crohn's disease: a review.

J Eur Acad Dermatol Venereol 2008 Sep 19;22(9):1033-43. Epub 2008 Jun 19.

Barnet & Chase Farm NHS Trust, Dermatology, London, UK.

Metastatic Crohn's disease (MCD) indicates the presence of non-caseating granuloma of the skin at sites separated from the gastrointestinal tract by normal tissue and is the least common dermatologic manifestation of CD. In adults, MCD usually appears after the initial diagnosis of CD in 70% of cases, whereas in children, it appears at the same time as CD in almost half of the cases. The most frequent skin lesions in adults are nodules, plaques with or without ulceration on the extremities and ulcers on the genitals. Read More

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http://dx.doi.org/10.1111/j.1468-3083.2008.02741.xDOI Listing
September 2008
9 Reads

Ectopic cutaneous schistosomiasis-perigenital infiltrative granulomata in a 34-year-old French pregnant woman.

Travel Med Infect Dis 2008 May 14;6(3):155-7. Epub 2008 Mar 14.

Department of Internal Medicine, Infectious Diseases and Tropical Medicine, University Hospital Center, Bordeaux F-33075, France.

Schistosomiasis, an infection with the three anthropophilic species of Schistosoma, is endemic throughout wide areas of the tropics and subtropics with an estimated rate of over 200 million people infected worldwide. Whereas symptoms and signs of vesical and gastrointestinal forms of the infection are recognized readily, cutaneous manifestations are still a challenging diagnosis particularly in Western countries. A case is described of a 34-year-old Caucasian pregnant woman who presented to our department and was diagnosed with a cutaneous schistosomiasis involvement of the perianal region. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S147789390800007
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http://dx.doi.org/10.1016/j.tmaid.2008.01.008DOI Listing
May 2008
13 Reads

Frequency and clinical correlations of granulomas in children with Crohn disease.

J Pediatr Gastroenterol Nutr 2008 Apr;46(4):392-8

Division of Gastroenterology, Hepatology, and Nutrition and Center for Inflammatory Bowel Diseases, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

Background: Granulomas are pathognomonic findings of Crohn disease (CD); however, their occurrence and clinical significance are not well characterized. Our aim was to determine the frequency and distribution of granulomas in untreated and treated patients with CD and their relation to age and disease severity.

Patients And Methods: Records from patients with CD undergoing colonoscopy with terminal ileum biopsy over 7 years were reviewed. Read More

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http://pdfs.journals.lww.com/jpgn/2008/04000/Frequency_and_C
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http://dx.doi.org/10.1097/MPG.0b013e31812e95e1DOI Listing
April 2008
12 Reads

Perianal skin tags in a patient with Crohn disease and a subclinical rectal stricture.

Cutis 2007 Nov;80(5):429-31

Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

A 21-year-old female-to-male transgender individual with a history of Crohn disease presented with enlarging perianal papules that initially were misdiagnosed as condyloma acuminatum. A biopsy specimen demonstrated granulomatous inflammation characteristic of Crohn disease. Although the patient's Crohn disease had been quiescent for years, a subsequent evaluation revealed the presence of a rectal stricture that was then dilated. Read More

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November 2007
21 Reads

Diverse effects of the CARD15 and IBD5 loci on clinical phenotype in 630 patients with Crohn's disease.

Eur J Gastroenterol Hepatol 2008 Jan;20(1):37-45

Division of Genetics and Molecular Medicine, King's College London School of Medicine, Guy's Hospital, London, UK.

Objectives: Genetic variants at the CARD15 and IBD5 loci are strongly associated with Crohn's disease (CD), but evidence of the effect of these variants on the clinical expression of CD is conflicting and has often been hampered by small sample sizes. We studied 630 well-characterized patients to clarify the genotype/phenotype relationship in CD.

Methods: Patients and healthy controls were genotyped for three common mutations in CARD15 and a marker of the IBD5 risk haplotype. Read More

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http://pdfs.journals.lww.com/eurojgh/2008/01000/Diverse_effe
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http://dx.doi.org/10.1097/MEG.0b013e3282f1622bDOI Listing
January 2008
20 Reads

Terminal ileum schistosomiasis with perianal fistula mimicking Crohn's disease.

Saudi Med J 2007 Sep;28(9):1449-52

Department of Medicine, Gastroenterology Division, Riyadh Armed Forces Hospital, PO Box 7897, Riyadh 11159, Kingdom of Saudi Arabia.

Schistosomiasis is a parasitic disease related to water contact in the agricultural fields, affecting millions of people in developing countries in tropical and subtropical parts of Africa, Asia, and South America. We report a case of a 27-year-old male, with intestinal schistosomiasis associated with perianal fistula mimicking Crohn's disease, where the terminal ileum showed a cobblestone appearance, and histopathological biopsy showed schistosoma granuloma. Read More

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September 2007
19 Reads

[Diagnosis and treatment of Crohn's disease in children: 10 years' clinical experience].

Zhonghua Er Ke Za Zhi 2007 Apr;45(4):248-51

Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Objective: To enhance our understanding of pediatric Crohn's disease and improve diagnostic accuracy and therapeutic efficacy by characterizing the clinical picture and reviewing 10 years' clinical experience in diagnosis and treatment.

Methods: Nine cases with active Crohn's disease diagnosed between 1996 and 2005, including 8 males and 1 female, aged 6 - 13 years, were reviewed. Clinical, radiologic, endoscopic and histological data as well as therapeutic results were analized. Read More

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April 2007
12 Reads

Primary perianal perineo-crural postpederasty donovanosis.

Authors:
A Ghorpade

Int J Dermatol 2007 Aug;46(8):855-7

Department of Dermatology, Venereology and Leprosy, J.L.N. Hospital & Research Center, Bhilai Steel Plant, Bhilai-India.

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http://doi.wiley.com/10.1111/j.1365-4632.2007.03186.x
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http://dx.doi.org/10.1111/j.1365-4632.2007.03186.xDOI Listing
August 2007
11 Reads

Perianal tuberculosis in an HIV-positive patient.

East Mediterr Health J 2006 Nov;12(6):923-6

Department of Tuberculosis and HIV/AIDS, National Research Institute of Tuberculosis and Lung Diseases, Tehran, Islamic Republic of Iran.

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November 2006
7 Reads