Search Our Scientific Publications & Authors

Rev Esp Enferm Dig 2022 Jun 24. Epub 2022 Jun 24.

Gastroenterology, Centro Hospitalar de Setúbal.

We present the case of a 40-year-old immunocompetent man with complaints of perianal abscess, diarrhea, and weight loss for 3 months. He denied respiratory symptoms. Colonoscopy revealed ulcers and histopathology showed non-necrotizing granulomas and excluded acid-fast bacilli. Read More

Indian J Radiol Imaging 2022 Mar 1;32(1):51-61. Epub 2022 May 1.

Department of Radiodiagnosis and Imaging, SRI Guru Ramdas Institute of Medical Sciences and Research, Vallah, Amritsar, Punjab, India.

 The aim of this study was to evaluate the role of transcutaneous perianal ultrasonography (TPUS) in patients with perianal fistula and to correlate the findings with magnetic resonance imaging (MRI) as gold standard.  This prospective study included patients who presented with suspicion of perianal fistula. After clinical examination, TPUS and MRI of perianal region were performed on each of them. Read More

J Community Hosp Intern Med Perspect 2022 2;12(3):86-88. Epub 2022 May 2.

UPMC, Harrisburg, PA, USA.

Background: Lactobacillus is a commensal that can be found as normal flora in the oropharynx, gastrointestinal and genitourinary tracts. Lactobacillus sepsis and bacteremia is usually found in immunocompromised individuals. In patients with no known underlying disease presenting with lactobacillus bacteremia, an extensive workup should be done before dismissing the organism as a contaminant. Read More

J Clin Gastroenterol 2022 Jun 10. Epub 2022 Jun 10.

Division of Gastroenterology and Hepatology.

Background And Goals: Perianal Crohn's disease (pCD) represents an aggressive phenotype with limited studies on long-term outcomes. We evaluated 5-year outcomes of these patients on biologic therapies.

Methods: We performed a retrospective analysis of patients with pCD at a tertiary medical center. Read More

Pediatr Neonatol 2022 May 21. Epub 2022 May 21.

Division of Pediatric Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

Surg Infect (Larchmt) 2022 Jun;23(5):465-469

Department of Pediatric General Surgery, Children's Hospital, Chongqing Medical University, Chongqing, P.R. China.

Non-surgical intervention has been proposed for the management of perianal abscess (PA) and fistula-in-ano (FIA), with potential benefits in terms of quality of life, wound healing, and functional outcome, although this strategy remains rare and controversial. Here, we aimed to compare the intermediate-term outcomes of non-surgical management with those of surgical incision and/or drainage. A study of pediatric patients with first-time PA and/or FIA was conducted retrospectively from January 2010 to December 2020. Read More

Front Surg 2022 12;9:908390. Epub 2022 May 12.

Department of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Anal canal duplication (ACD) is a very rare duplication of the gastrointestinal tract and is described as a secondary anal orifice along the posterior side of the normal anal canal. Early surgical removal is advisable, also in asymptomatic patients, because of the risk of inflammatory complications, such as recurrent crissum abscess, and malignant changes.

Case Presentation: A previously healthy 2-year-old boy was evaluated in the emergency department with fever. Read More

Am Surg 2022 May 27:31348221101481. Epub 2022 May 27.

Department of General Surgery, 26743Shaare Zedek Medical Center, The Hebrew University School of Medicine, Jerusalem, Israel.

Background: Acute anorectal abscess and fistula are common conditions that usually presents as a painful lump close to the anal margin. Tumors in the distal rectum and in the perianal region may mimic the symptoms and signs of anorectal sepsis, thereby leading to a delay in diagnosis and management. The purpose of this study was to describe patients presenting with acute perianal abscess or fistula who were subsequently diagnosed with anorectal cancer. Read More

Front Pediatr 2022 6;10:862317. Epub 2022 May 6.

Department of Anorectal Surgery, Affiliated Hospital of Jining Medical University, Jining, China.

Objective: Perianal abscess (PA) in neonates is poorly understood, and its management remains controversial. The aim of this study was to compare incision and drainage (ID) with or without primary fistulotomy in the management of neonatal first-time PA.

Methods: A retrospective comparative study was conducted for neonates with first-time PA treated with incision and drainage with primary fistulotomy (IDF) vs. Read More

Int J Surg Case Rep 2022 Jun 11;95:107187. Epub 2022 May 11.

Department of Surgery, Tahar Sfar Hospital, Mahdia, Tunisia.

Introduction And Importance: Epidermoid cysts are developmental cysts of the retrorectal space. They are benign lesions resulting from ectodermal inclusion during neural tube closure. Generally, they are misdiagnosed given that symptoms are often vague and nonspecific. Read More

BMJ Case Rep 2022 May 13;15(5). Epub 2022 May 13.

General, Visceral and Proctological Surgery, DIAKOMED Diakoniekrankenhaus Chemnitzer Land gGmbH, Hartmannsdorf, Saxony, Germany.

We present a case of vaginocutaneous fistula 10 years after pelvic floor reconstruction using transvaginal mesh implantation. The female patient in her mid-60s presented with typical symptoms of perianal abscess. After undergoing three surgical operations, the perianal infection was shown to be due to the implanted mesh as a late complication of the reconstruction. Read More

BMJ Case Rep 2022 May 6;15(5). Epub 2022 May 6.

General Surgery Department, Queen Elizabeth University Hospital, Glasgow, UK.

This case report describes a patient with complicated Crohn's disease who presented to a routine gastroenterology clinic complaining of increasing white discharge from a chronic perianal abscess. MRI of the perineum established the diagnosis of a seminal vesicle fistula connecting to the perianal skin. He was treated conservatively, with optimisation of his Crohn's disease medication regime. Read More

World J Surg 2022 Apr 30. Epub 2022 Apr 30.

Department of Surgery, Aga Khan University Hospital, PO BOX: 47800, Karachi, Pakistan.

Background: In view of importance for competency-based education (CBE), we undertook a self-study to elicit the available operative surgical workload and supervision for residents in the general surgical residency program at the teaching hospital in Karachi.

Methodology: This was a cross-sectional study spanning a 5-year period between January 2015 and December 2019. The numbers of surgical residents during this period were identified. Read More

J Pediatr Surg 2022 Apr 4. Epub 2022 Apr 4.

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Toronto, Toronto, ON, Canada; SickKids Inflammatory Bowel Disease Center, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Objectives: Complex perianal fistulas (CPFs) in children even in the absence of luminal symptoms prompt evaluation for Crohn's disease (CD). Reports of isolated CPF in children, however, are sparse. In perianal CD, antitumor necrosis factor α (anti TNF) therapy is recommended. Read More

ANZ J Surg 2022 Apr 29. Epub 2022 Apr 29.

Department of Colorectal Surgery, Bankstown Hospital, Sydney, Australia.

Background: Perianal abscesses are a common surgical emergency. Due to their perceived ease, drainage is often delegated to junior trainees with varying levels of experience. The purpose of this study is to evaluate the current trend in perianal abscesses management at our institution, and identify factors that predict subsequent fistula formation or abscess recurrence. Read More

Port J Card Thorac Vasc Surg 2021 Nov 7;28(3):47-49. Epub 2021 Nov 7.

Angiology and vascular surgery, Santiago Compostela Clinical Hospital, Galicia, Spain.

Introduction: Gluteal pseudoaneurysms are extremely rare and respond to pelvic trauma, penetrating wounds, inflammation or infection in the gluteal region.

Clinical Cases: Two men, 73 and 82 years respectively, who presented gluteal pseudoanerysm after drainage of perianal abscess the first one and after trauma the second one. In both cases the diagnosis was made by imaging tests (doppler ultrasound that was completed with computed tomographic angiography). Read More

J Pak Med Assoc 2022 Mar;72(3):544-548

Department of Medicine, Dow University of Health Sciences, Ojha Campus, Karachi, Pakistan.

Rhabdomyosarcoma is a rare and highly aggressive malignancy arising from the striated skeletal muscle fibre. It is commonly a childhood tumour and rarely seen in adults. The most predominant part commonly involved is head and neck. Read More

Ann Ital Chir 2022 ;93:183-187

Aim: To investigate the impact of mesalazine co-treatment in addition to the surgical intervention on recurrence rate in subjects with subclinical inflammatory bowel disease (SIBD) who present with perianal fistula (PAF).

Materials And Methods: All consecutive patients who had undergone surgery for PAF in our institutes were included in this retrospective analysis. Ileal tissue samples were obtained during colonoscopy for pathological evaluation. Read More

Ann Transl Med 2022 Jan;10(2):108

Graduate School, Beijing University of Traditional Chinese Medicine, Beijing, China.

Background: High perianal abscess is an emergency in the anorectal department. It can result in long-term pain and a huge psychological burden to patients, and seriously affects the quality of life of patients. At present, the effect of antibiotics alone for high perianal abscess is not satisfactory. Read More

Int J Environ Res Public Health 2022 03 2;19(5). Epub 2022 Mar 2.

Faculty of Medicine, Medical College of Rzeszow University, 35-959 Rzeszow, Poland.

Anal abscesses and fistulas are potential complications of Crohn's disease (CD). Chronic immunosuppression, loose stools, and poor wound healing in this population present challenges to the management of perianal diseases. The purpose of the study was to determine the predominant bacterial species found in specimens from perianal lesions causing anal abscess and/or fistula drainage in hospitalized patients, and to compare the number and type of microorganisms isolated from samples taken from patients undergoing biological therapy or traditionally treated. Read More

Clin Case Rep 2022 Mar 1;10(3):e05408. Epub 2022 Mar 1.

General Pediatrics Department, Allergy and Immunology Section Children's Specialized Hospital King Fahad Medical City Riyadh Saudi Arabia.

Herein, we report a case of VAIHS with atypical clinical presentation of perianal abscess, fistula fever, and bi-cytopenia including pathogenic ADA2 mutation suggesting that ADA2 deficiency be considered as a differential diagnosis of enlarging cutaneous abscess with no evidence of wound healing in the setting of leukopenia and neutropenia. Read More

Arch Pediatr 2022 Apr 3;29(3):171-176. Epub 2022 Mar 3.

Third Department of Pediatrics, Attikon University General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Benign anorectal disease refers to a diverse group of frequent anorectal complaints that cause considerable discomfort, disability, and often constitute a significant problem for the child and his or her family. Hemorrhoids, fissures, rectal prolapse, and perianal abscess and fistulas are the most common anorectal disorders in pediatric population and their appearance may be age-specific. Although they generally follow a benign course, a careful examination must be performed in order to exclude other serious and complicated underlying pathology. Read More

Cureus 2022 Jan 26;14(1):e21622. Epub 2022 Jan 26.

General Medicine, Jichi Medical University Saitama Medical Center, Saitama, JPN.

A sixty-year-old man with ulcerative colitis and polymyalgia rheumatica, for which he was receiving prednisolone, visited the emergency department complaining of a gradual worsening of pain in the right buttock. Physical examination revealed mild redness and tenderness at the right side of the anus. Ultrasound revealed an approximately 38-mm long, avascular subcutaneous collection with heterogeneous echogenicity in the tender region. Read More

JNMA J Nepal Med Assoc 2021 Sep 11;59(241):929-931. Epub 2021 Sep 11.

Department of Anesthesiology and Critical Care, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.

Stuttering is a form of speech disorder characterized by involuntary prolongation and repetition of sound, words, syllables or phrases as well as involuntary silent pauses or blocks. We report a case of a healthy twenty-six-year-old male patient without significant past history, who underwent short intravenous anesthesia for incision and drainage for perianal abscess. Postoperatively, the patient presented with prominent stuttering after six hours of surgery. Read More

Front Surg 2022 7;9:834870. Epub 2022 Feb 7.

Department of Surgery, Luigi Sacco University Hospital, University of Milan, Milan, Italy.

From 30 to 70% of patients with Crohn's disease (CD) may develop perianal fistulas during their lifetime. The medical and surgical management of this complication is challenging, and its treatment still gives unsatisfactory results. However, recent studies on adipose-derived mesenchymal stem cells have proven their anti-inflammatory and immuno-modulatory potential, representing a new promising tool in the treatment of such stubborn disease. Read More

Front Surg 2021 24;8:806497. Epub 2022 Jan 24.

Chirurgia Generale III, Department of Surgical Oncological and Gastroenterological Sciences, Azienda Ospedale Università di Padova, Padua, Italy.

Introduction: Often, in perineal Crohn's disease (CD), a seton is placed to guarantee a constant drainage and prevent septic complication while biologic therapy is ongoing. This study aimed to assess the long-term quality of life after surgery for perineal CD in relation to seton placing.

Patients And Methods: Data of 65 consecutive patients with CD and non-CD operated on from 2014 to 2019 for perianal fistula or abscess were retrieved. Read More

Front Immunol 2021 24;12:803763. Epub 2022 Jan 24.

Allergy & Immunology Unit, Department of Paediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Chronic granulomatous disease (CGD) is an inborn error of immunity (IEI), characterised by recurrent bacterial and fungal infections. It is inherited either in an X-linked (XL) or autosomal recessive (AR) mode. Phenome refers to the entire set of phenotypes expressed, and its study allows us to generate new knowledge of the disease. Read More

World J Clin Cases 2022 Jan;10(3):1122-1130

Department of Colorectal Surgery, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210022, Jiangsu Province, China.

Background: Distant metastasis of colorectal cancer to the anus is very rare, with only 30 related cases published in PubMed thus far. Therefore, recurrence of colorectal cancer derived anus metastases is rarely seen and less presented.

Case Summary: Here we report an 80-year-old male patient who underwent radical resection for sigmoid colon cancer in January 2010 and another surgery for anal fistula resection in December 2010. Read More

Prim Care 2022 Mar 5;49(1):39-45. Epub 2022 Jan 5.

Department of Medical Education and Clinical Sciences, Washington State University, 412 East Spokane Falls Boulevard, Spokane, WA 99202-1495, USA. Electronic address:

An abscess is a localized collection of purulent material surrounded by inflammation and granulation in response to an infectious source. Most simple abscesses can be diagnosed upon clinical examination and safely be managed in the ambulatory office with incision and drainage. Wound culture and antibiotics do not improve healing, but packing wounds larger than 5 cm may reduce recurrence and complications. Read More

Transl Cancer Res 2021 Feb;10(2):627-636

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), the VIP-II Gastrointestinal Cancer Division of the Medical Department, Peking University Cancer Hospital & Institute, Beijing, China.

Background: Apatinib, an inhibitor of vascular endothelial growth factor receptor (VEGFR), has been used to treat esophagogastric adenocarcinoma. However, the dosage of apatinib varies greatly in clinical practice, and its safety in esophageal squamous cell carcinoma (ESCC) patients is unclear. Therefore, we initiated a phase 1 dose-escalation trial to identify the maximum tolerated dose (MTD) of apatinib when combined with irinotecan in ESCC. Read More