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Zhonghua Er Ke Za Zhi 2020 Jul;58(7):570-575

Department of Gastroenterology, Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.

To analyze the clinical characteristics and efficacy of drug treatment in children with inflammatory bowel disease (IBD) at different ages of onset. The clinical data of 87 children with IBD admitted to Department of Gastroenterology in Children's Hospital, Capital Institute of Pediatrics from January 2009 to December 2018 were collected. The patients were divided into four groups according to the age of onset: 0 -<2 years old group (36 cases), 2 -<6 years old group (10 cases), 6 -<10 years old group (12 cases) and 10 -<18 years old group (29 cases). Read More

Int J Surg Case Rep 2020 Jun 6;72:96-98. Epub 2020 Jun 6.

University of Health Science, Istanbul Haydarpasa Education and Research Hospital, Department of General Surgery Istanbul, Turkey. Electronic address:

Background: Pilonidal sinus usually arises in the area of natal cleft in young men. Hair accumulation in the wound in the perianal region is very rare. Although pelvic magnetic resonance imaging (MRI) is used in the differential diagnosis of perianal region diseases, it is not possible to diagnose perianal pilonidal sinus by MRI. Read More

Therap Adv Gastroenterol 2020 18;13:1756284820922003. Epub 2020 May 18.

Gastroenterology Department, Tenth People's Hospital of Tongji University, Shanghai, China.

Aim: The aim of this study was to investigate the significance of positive tuberculosis interferon gamma release assay (TB-IGRA) in the differential diagnosis of intestinal tuberculosis (ITB) and Crohn's disease (CD) patients, and to find a suitable threshold to help distinguishing CD from tuberculosis (TB), so as to provide better recommendations for clinical treatment.

Methods: A retrospective study was performed including 484 patients who underwent TB-IGRA testing for suspected CD or ITB treated in the Shanghai Tenth People's Hospital of Tongji University between January 2015 and May 2018. According to the diagnostic criteria, 307 patients, including 272 CD and 35 ITB patients, were recruited for the final analysis. Read More

Case Rep Dermatol 2020 May-Aug;12(2):83-91. Epub 2020 May 5.

Department of Dermatology, Alpert Medical School, Brown University, Providence, Rhode Island, USA.

Mannose-binding lectin (MBL) deficiency is associated with recurrent infections, autoimmune and inflammatory skin disease, and vascular complications. MBL deficiency is not a recognized comorbidity in hidradenitis suppurativa (HS); the latter is associated with the group of autoinflammatory disorders. A 32-year-old woman presented with a history of recurrent painful, deep-seated abscesses and pustular lesions since the age of 13 years. Read More

Trials 2020 Jun 1;21(1):451. Epub 2020 Jun 1.

Department of Digestive Surgery, Amiens University Hospital, Amiens University Medical Center, Avenue Laennec, F-80054, Amiens cedex 01, France.

Background: Approximately 30% of appendectomies are for complicated acute appendicitis (CAA). With laparoscopy, the main post-operative complication is deep abscesses (12% of cases of CAA, versus 4% for open surgery). A recent cohort study compared short and long courses of postoperative antibiotic therapy in patients with CAA. Read More

J Pediatr Gastroenterol Nutr 2020 May 22. Epub 2020 May 22.

Department of Pediatric Gastroenterology, Susan and Leonard Feinstein IBD Clinical Center, Icahn School of Medicine at Mount Sinai, New York.

Coronavirus disease 2019 (COVID-19) may lead to a severe inflammatory response referred to as a cytokine storm. We describe a case of severe COVID-19 infection in a recently diagnosed pediatric Crohn's disease patient successfully treated with Tumor Necrosis Factor-alpha (TNF-α) blockade. The patient presented with five days of fever, an erythematous maculopapular facial rash, and abdominal pain without respiratory symptoms. Read More

Zhongguo Dang Dai Er Ke Za Zhi 2020 May;22(5):478-481

Department of Pediatrics, Peking Union Medical College Hospital, Beijing 100730, China.

Objective: To summarize the extraintestinal manifestations and intestinal complications in children with Crohn's disease (CD).

Methods: The clinical data of 54 children who were diagnosed with CD in Peking Union Medical College Hospital from January 2008 to December 2018 were collected for retrospective analysis of extraintestinal manifestations and intestinal complications. According to the location of the lesion, the children were divided into ileocolonic group (30 cases), colonic group (6 cases), and ileal group (18 cases). Read More

Clin Exp Pediatr 2020 May 15. Epub 2020 May 15.

Department of General and Visceral Surgery, Helios University Hospital Wuppertal, University Witten-Herdecke, Wuppertal, Germany.

Background: The optimal management of perianal abscess in children is controversial.

Purpose: To evaluate the efficiency of conservative treatment of perianal abscess in children and identify parameters that predict therapy failure.

Methods: All cases of children younger than 14 years of age with perianal abscesses between 2001-2016 were evaluated. Read More

Colorectal Dis 2020 06 18;22(6):645-646. Epub 2020 May 18.

Minimally Invasive and GI Surgery, Policlinico Tor Vergata, Rome, Italy.

Abdom Radiol (NY) 2020 Apr 27. Epub 2020 Apr 27.

Department of Medical Imaging, The Ottawa Hospital, Ottawa, Ontario, Canada.

Fournier gangrene is an emergency condition that is associated with a high mortality rate. It is defined as a rapidly progressing infective necrotizing fasciitis of the perineal, perianal, and genital regions. Early diagnosis, broad-spectrum antibiotic coverage, and adequate surgical debridement are crucial and lead to better prognosis and patient survival. Read More

Clin Res Hepatol Gastroenterol 2020 Apr 23. Epub 2020 Apr 23.

Department of Gastroenterology, Amiens University Hospital, Picardie University, Amiens, France.

Introduction: Most anal fistulas are crypto-glandular. Nevertheless, anal fistulas can reveal Crohn's disease (CD). The aim of our study was to evaluate the risk of developing CD in patients undergoing surgery for anal fistula. Read More

Clin Radiol 2020 Jul 22;75(7):563.e1-563.e9. Epub 2020 Apr 22.

Department of General Surgery, Gazi University Faculty of Medicine, Ankara, Turkey.

Aim: To evaluate volumetric contrast-enhanced three-dimensional T1-weighted (CE 3D T1) turbo spin-echo (TSE) with variable flip angle (SPACE), CE 3D T1 volumetric interpolated breath-hold examination (VIBE) sequences with conventional CE-two-dimensional (2D)-T1 and 2D-T2-weighted imaging (WI) sequences in assessing perianal fistulas.

Methods And Materials: Twenty-three patients with perianal fistula were included in this prospective study and underwent pelvic magnetic resonance imaging (MRI) at 3 T including fat-supressed CE 3D T1 SPACE, CE 3D T1 VIBE, axial and coronal 2D-T1WI together with 2D-T2WI sequences in the axial and coronal planes. Acquisition times were recorded. Read More

Pol Przegl Chir 2020 Feb;92(2):29-33

Klinika Chirurgii Dziecięcej i Transplantacji Narządów, Instytut "Pomnik - Centrum Zdrowia Dziecka", Warszawa.

Introduction: Perianal abscess and fistula-in-ano are common findings in infants and children. The perianal abscess is usually a manifestation of a fistula-in-ano. Experience of our center indicates general lack of knowledge of the origin of the abscess and therefore, it is usually treated by incision and drainage, which leads to repeated recurrences. Read More

Int J Colorectal Dis 2020 Jun 16;35(6):1149-1153. Epub 2020 Apr 16.

Department of Surgery, Ospedale GM Vannini, Istituto Figlie di San Camillo, Rome, Italy.

Purpose: The management of complex anal fistulas remains a challenge, mainly due to the considerable risk of incontinence. We compared LIFT and VAAFT in the treatment of complex anal fistulas in terms of healing time, recurrence, continence, morbidity, and postoperative pain, focusing also on patients with local abscess at the time of surgery.

Methods: We include all patients with high trans-sphincteric anal fistula even with abscess at the time of surgery. Read More

Scand J Gastroenterol 2020 Apr 14;55(4):442-448. Epub 2020 Apr 14.

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.

Granuloma, mainly composed of macrophages, is a histological feature of Crohn's disease (CD). However, its significance in CD has not been investigated adequately. Our study aims to address this issue by comparing the clinical manifestations and monocyte/macrophage subtypes between granulomatous and non-granulomatous CD. Read More

JGH Open 2020 Apr 15;4(2):303-305. Epub 2019 Aug 15.

Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India.

Intestinal involvement in Behcet's disease (BD) is uncommon. Differentiating it from close mimics like Crohn's Disease is difficult. Further, in asymptomatic cases, diagnostic challenges posed is still greater. Read More

Khirurgiia (Mosk) 2020 (3):89-96

A.N. Ryzhikh State Scientific Center of Coloproctology of the Ministry of Health of Russia, Moscow, Russia.

Objective: To analyze efficacy and safety of submucosal laser ablation of internal hemorrhoids (SLT).

Material And Methods: Systematic review included 10 articles published in electronic databases PubMed, Cochrane Library, Elibrary until January 2019. There were only full-text publications from prospective clinical trials devoted to submucosal laser ablation in the treatment of hemorrhoids. Read More

Case Rep Surg 2020 18;2020:5750382. Epub 2020 Mar 18.

Radiology Department, King Abdullah Bin Abdulaziz University Hospital, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

A retrorectal epidermoid cyst is an uncommon congenital lesion that arises from the remnants of the embryonic tissues. This type of cyst is difficult to diagnose before surgery. In this study, we report a rare case of a giant retrorectal epidermoid cyst in a 30-year-old woman. Read More

Clin Exp Pediatr 2020 Mar 23. Epub 2020 Mar 23.

Department of Pediatric Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.

ANZ J Surg 2020 Jun 4;90(6):1034-1036. Epub 2020 Mar 4.

Department of Paediatric Surgery, Monash Children's Hospital, Melbourne, Victoria, Australia.

Background: The optimal management of perianal abscess in neonates and infants remains unclear, including the need for laying open of the fistula and the role of microscopy and culture studies (MCS). We aimed to report the recurrence rate following incision and drainage alone (I&D) compared to incision and drainage with laying open of the fistula (I&DF) and to determine the value of MCS in perianal abscess management.

Methods: Following ethical approval (16326Q), a 10-year (2007-2017) review of children younger than 1 year presenting with a perianal abscess was performed. Read More

Dis Colon Rectum 2020 Jun;63(6):831-836

Department of Surgery, Bursa Medicana Hospital, Bursa, Turkey.

Background: Ablation of anal fistula tract using a radial laser-emitting probe is a sphincter-preserving technique.

Objective: The purpose of this study was to assess long-term outcomes of laser ablation of fistula tract.

Design: This was a retrospective analysis of the long-term outcomes of 100 patients who underwent laser ablation of fistula tract. Read More

Plast Reconstr Surg Glob Open 2020 Jan 24;8(1):e2604. Epub 2020 Jan 24.

Department of Surgery, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.

Managing cavity wounds that cannot be cleaned using standard irrigating solution is challenging. An immunocompromised patient with a horseshoe perianal abscess was selected to represent a heavy infection in cavity wounds. Diluted povidone-iodine was initially used to lavage the wounds, but the fever persisted and the irrigation was painful. Read More

Am J Case Rep 2020 Feb 24;21:e920115. Epub 2020 Feb 24.

Department of Clinical Pharmacy, Winchester District Memorial Hospital, Winchester, Ontario, Canada.

BACKGROUND Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a class of antihyperglycemic medications associated with an increased risk of urinary and genital infections due to their glycosuric effects. In 2018, the FDA issued a safety alert warning that multiple cases of Fournier's Gangrene (FG), a severe genital infection, had been reported in patients taking SGLT2 inhibitors. CASE REPORT We present a case of 72-year-old male with type II diabetes mellitus who developed FG while taking the SGLT2 inhibitor canagliflozin. Read More

Ann Coloproctol 2020 Jan 31. Epub 2020 Jan 31.

General hospital of Patras, Greece, Patras, Greece.

Background: Supralevator abscess is a rare form of anorectal disease responsible for very rare but morbid manifestations, one of which is spreading superiorly through fascial planes.

Case Presentation: We present a rare case of a spreading anorectal abscess presented only as diffuse abdominal pain and review similar cases of the literature according to the anatomical considerations, presentation, diagnostic procedures and treatment options.

Discussion: We identified seven cases of spreading anorectal abscesses. Read More

World J Surg Oncol 2020 Feb 3;18(1):26. Epub 2020 Feb 3.

Department of the General Surgery, The Second Hospital of Jilin University, Changchun, Jilin Province, China.

Background: Even with the augmentative application of anal-preservation surgery in low rectal cancer, the role and indications of laparoscopic intersphincteric resection (Lap ISR) are still under debate, especially for T3 or node-positive (T3N0M0, T1-3N+M0) cancer, mainly due to the oncological safety and functional outcomes. INTRABEAM (Carl Zeiss, Germany) intraoperative radiotherapy (IORT) using low-energy X-rays features in accurate irradiation, less exposure, and reduced complications. Taking advantages of Lap ISR and INTRABEAM IORT, this innovative approach aims to increase the probability of the anal preservation with acceptable postoperative outcomes. Read More

Pediatr Gastroenterol Hepatol Nutr 2020 Jan 9;23(1):49-62. Epub 2020 Jan 9.

Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea.

Purpose: We aimed to investigate the disease phenotype of Korean pediatric Crohn's disease (CD) patients at diagnosis according to the Paris classification by comparison with patients from the European multicenter 5-years recruitment of children with newly developed IBD (EUROKIDS registry).

Methods: Korean children and adolescents who had been newly diagnosed with CD at the age of <18 years during 2013-2016 were included in this multicenter retrospective study. Disease phenotype at diagnosis was classified according to the Paris classification, and compared with the published data from the EUROKIDS study. Read More

Tech Coloproctol 2020 02 23;24(2):127-143. Epub 2020 Jan 23.

Diagnostic Imaging Centre "Diagnostica Marche", Osimo Stazione, Ancona, Italy.

Perianal sepsis is a common condition ranging from acute abscess to chronic anal fistula. In most cases, the source is considered to be a non-specific cryptoglandular infection starting from the intersphincteric space. Surgery is the main treatment and several procedures have been developed, but the risks of recurrence and of impairment of continence still seem to be an unresolved issue. Read More

Pol J Radiol 2019 4;84:e430-e435. Epub 2019 Nov 4.

Memorial Ankara Hospital, Ankara, Turkey.

Purpose: Perianal fistula is an important health problem with devastating morbidity. For diagnosis and prevention of recurrence, perianal fistula imaging (PFI) is crucial. The aim of this study was to investigate if a Flex-M superficial coil images would provide more information than images obtained with a phased-array body coil in PFI. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Jan;23(1):71-75

Department of General Surgery, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China.

To evaluate the long-term healing rate of transsphincteric anal fistula treated with anal fistula plug procedure and the risk factors affecting the healing of anal fistula. A retrospective case-control study was conducted to analyze the clinical data of 207 patients with transsphincteric anal fistulas who received anal fistula plug procedure at the Department of General Surgery, Beijing Chaoyang Hospital of Capital Medical University from August 2008 to September 2012. Inclusion criteria: (1) consistent with the diagnosis of transsphincteric anal fistula: the anal fistula passed through the internal and external sphincter; (2) complete data; (3) initial treatment with anal fistula plug procedure. Read More

Scand J Gastroenterol 2020 Jan 9;55(1):55-61. Epub 2020 Jan 9.

Department of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China.

Cytomegalovirus (CMV) is rarely thought to be the cause of significant gastrointestinal infection in immunocompetent children. CMV colitis is seldom observed in young infants. This study aims to examine the clinical features of CMV colitis in Chinese children. Read More

Dis Colon Rectum 2020 02;63(2):129-132

Division of Colon and Rectal Surgery, Department of Surgery, New York-Presbyterian, Columbia University Medical Center, New York, New York.

Vnitr Lek 2019 ;65(11):712-714

Spinal epidural abscess (SEA) is a rare disease that occurs mainly in immunocompromised patients after spinal surgery or spinal trauma and can lead to a severe neurological deficit or even death if diagnosed too late. However, cases of SEA have also been reported in patients with fistulising Crohn´s disease (CD). We present a case of a young patient with CD and a history of relapsing perianal disease followed by a complication of SEA in the thoracic spine. Read More

Am Fam Physician 2020 01;101(1):24-33

University of Virginia School of Medicine, Charlottesville, VA, USA.

Common anorectal conditions include hemorrhoids, perianal pruritus, anal fissures, functional rectal pain, perianal abscess, condyloma, rectal prolapse, and fecal incontinence. Although these are benign conditions, symptoms can be similar to those of cancer, so malignancy should be considered in the differential diagnosis. History and examination, including anoscopy, are usually sufficient for diagnosing these conditions, although additional testing is needed in some situations. Read More

J Surg Case Rep 2019 Dec 17;2019(12):rjz331. Epub 2019 Dec 17.

Department of General Surgery, Seth G.S. Medical College & K.E.M Hospital, Mumbai 400053, Maharashtra, India.

Clinical diagnosis of pararectal masses remains a challenge to this day. Despite the availability of advanced imaging facilities, we often fail to reach a definitive diagnosis and have to resort to surgery. We describe a case of a 60-year-old female with a painless perianal swelling gradually increasing in size for 6 months with spontaneous reduction on assuming a supine position. Read More

Eur J Gastroenterol Hepatol 2020 Feb;32(2):187-192

Department of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

Background And Aims: Perianal fistulizing Crohn's disease (PFCD) leads to significant disability. Data assessing healing of complex PFCD based on pelvic MRI using Parks' classification remains sparse. We aimed to assess the frequency of closure of fistula tract on MRI in patients treated with antitumor necrosis factor alpha antagonists and identify predictors of poor response. Read More

J Gastrointest Surg 2019 Dec 10. Epub 2019 Dec 10.

Coloproctology Unit Clinical Management Unit of General and Gastrointestinal Surgery Division Seville, Biomedical Research Institute (IBIS), Avenida Manuel Siurot s/n, 41013, Seville, Spain.

Aim: To assess clinical healing in patients with perianal Crohn's disease with local intrafistular injection of autologous platelet-rich plasma.

Method: The pilot study was conducted at a single centre between January 2013 and December 2015. Autologous platelet-rich plasma was prepared in platelet-rich and platelet-poor fractions for local intrafistular injection in patients with proven, established perianal Crohn's disease. Read More

Clin Pract Cases Emerg Med 2019 Nov 18;3(4):349-353. Epub 2019 Sep 18.

The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.

Perineal and rectal pain are common presentations in the emergency department (ED). In the majority of cases, clinical examination is sufficient to detect local anorectal pathologies. However, perianal and rectal abscesses and fistulas are often the primary concerns prompting diagnostic imaging in the ED. Read More

Asian Pac J Allergy Immunol 2019 Nov 3. Epub 2019 Nov 3.

Department of Pediatrics, Faculty of Medicine Ramathibodi hospital, Mahidol University, Ratchathewi, Bangkok, Thailand.

Backgound: HLA-matched hematopoietic stem cell transplantation (HSCT) is the curative treatment for chronic granulomatous disease (CGD).

Objective: To report a case of X-linked CGD with active infection successfully treated by haploidentical HSCT with post-transplant high dose cyclophosphamide (PTCY).

Methods: A 5-year-old Thai boy with CGD was undergone for haploidentical HSCT using PTCY with correction of the phagocytic function. Read More

Inflamm Bowel Dis 2019 Oct 21. Epub 2019 Oct 21.

Division of Colon and Rectal Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.

Introduction: Due to concerns over wound healing, hemorrhoidectomy in patients with Crohn's disease (CD) remains controversial. We sought to ascertain safety and efficacy of excisional hemorrhoidectomy in CD.

Methods: A retrospective review of all adult CD patients undergoing excisional hemorrhoidectomy between January 1, 1995, and January 1, 2019, at 2 IBD referral centers was performed. Read More

Clin Ter 2019 Sep-Oct;170(5):e328-e331

Department of Experimental Biomedicine and Clinical Neuroscience, University of Palermo, Italy.

Primary perianal fistulous pathology represents a painful condition often noticeable in patients affected by Crohn's disease or Ulcerative colitis. It causes difficult defecation and can evolve in perianal abscess that should be urgently ascertained and drained. The present work aims to propose Argentum-Quartz® as valid non-surgical therapeutic treatment in order to reach a more comfortable perianal fistula healing. Read More

Plast Reconstr Surg Glob Open 2019 Aug 12;7(8):e2387. Epub 2019 Aug 12.

Babtain Center of Plastic and Reconstructive Surgery, ibn-Sina Hospital, Ministry of Health, Shuwaikh, Kuwait.

The chronic inflammatory skin condition hidradenitis suppurativa (acne inversa), characterized by hair follicle or apocrine gland infection, causes recurrent superficial nodules and abscesses in axillary, mammary, and perianal regions. Chronic reoccurrence results in fistula formation, causing scarring and fibrosis. Surgical excision of affected skin tissue with adequate free margins is the gold standard treatment to prevent recurrence. Read More

Dis Colon Rectum 2019 12;62(12):1505-1511

Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota.

Background: Controversy in performing hemorrhoidectomy and anal skin tag excision in patients with IBD stems from dated reports of nonhealing wounds resulting in proctectomy.

Objective: This study aimed to determine the safety of interventional management of hemorrhoids or anal skin tags in patients with Crohn's disease or ulcerative colitis.

Design: This study is a retrospective review of patient records from 2000 to 2017. Read More

Turk J Pediatr 2019 ;61(1):40-43

Department of General Surgery, The First Affiliated Hospital of Lishui University, Lishui, China.

Zhu Y, Xu F. The pathogens and curative effects analysis of perianal abscess of infants under 3 months. Turk J Pediatr 2019; 61: 40-43. Read More

Clin Colon Rectal Surg 2019 Sep 6;32(5):377-385. Epub 2019 Sep 6.

Division of Colorectal Surgery, Hospital Santa Helena Los Álamos, Málaga, Spain.

This article provides an overview of the principles in the evaluation and management of perianal Crohn's disease (CD). Manifestation-specific treatment is addressed including abscess, fistula, skin tags, hemorrhoids, fissure, ulcers, strictures, ano-, and rectovaginal fistulas as well CD-associated hidradenitis suppurativa. Read More

Inflamm Bowel Dis 2020 May;26(6):926-931

Hépato-gastro-entérologie, Centre Hospitalier Universitaire, Bordeaux, France.

Background: Despite an optimal medico-surgical management of perineal Crohn's disease (PCD), fistula relapse still occurs in 30% of patients. Our aim was to determine predictors of fistula relapse in patients in remission after treatment of a PCD lesion.

Methods: Consecutive patients treated for fistulizing PCD have been included in a retrospective study when they achieved fistula remission within 3 months after the surgery. Read More

Pediatr Int 2019 Nov 13;61(11):1146-1150. Epub 2019 Nov 13.

Department of Pediatric and Adolescent Surgery, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Background: Perianal abscess is a common surgical condition in daily pediatric practice. Management is a subject of controversy and a variety of approaches are practiced. While the most frequent approach is drainage with/without fistulotomy, the superiority of this approach and the place of conservative approach has not been established. Read More

Exp Ther Med 2019 Sep 12;18(3):1539-1544. Epub 2019 Jul 12.

Department of Colorectal and Anal Surgery, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang 321000, P.R. China.

Efficacy of insulin with different administrations for patients with diabetes complicated with perianal abscess and the effect on serum inflammatory cytokines were investigated. One hundred and sixty-seven patients with type 2 diabetes who underwent radical operation of perianal abscess in Jinhua Hospital of Zhejiang University from January 2014 to December 2016 were analyzed. Before and after the operation, 89 patients who received continuous intravenous pumping of insulin for blood glucose control were set as an observation group, and 78 patients who received intermittent subcutaneous injection of insulin as a control group. Read More

Pediatr Int 2019 Oct;61(10):1025-1029

Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, Tokyo, Japan.

Background: Combination therapy with two different traditional medicine formulations called hainosankyuto and juzentaihoto (TJ-122 and TJ-48; Tsumura & Co, Tokyo, Japan) may be effective for perianal abscess (PA), but their effectiveness has not been established. The present study investigated the effectiveness of combination therapy with TJ-122 and TJ-48 as the most effective conservative treatment for PA.

Methods: We identified 69 patients with PA under 2 years of age and divided them into four groups according to the formulations used: group 1, TJ-122 (n = 17); group 2, TJ-48 (n = 14); group 3, TJ-122 and TJ-48 (n = 19); and group 4, no traditional medicines (n = 19). Read More