2,007 results match your criteria Perfusion[Journal]


Mycobacterium chimaera in heater-cooler units: new technical approach for treatment, cleaning and disinfection protocol.

Perfusion 2018 Dec 12:267659118814691. Epub 2018 Dec 12.

2 Department of Cardiac Surgery, IRCCS San Raffaele Hospital, Milan, Italy.

Mycobacterium chimaera infections have mainly been associated with the heater-cooler unit (HCU) and, ultimately, linked to contaminated aerosols in the operation room. The contamination status of HCUs seems to be influenced by the maintenance, therefore, according to the manufacturer's recommendations, peracetic acid (Puristeril) was introduced to increase HCU cleaning and disinfection protocol maintenance. Aerosol dispersion from Puristeril during maintenance can cause adverse effects to nearby workers. Read More

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December 2018

Vascular anatomical considerations and clinical decision making during insertion of the Avalon Elite Dual Lumen single-site veno-venous ECMO cannula in children weighing less than 20 kg.

Perfusion 2018 Dec 11:267659118815104. Epub 2018 Dec 11.

4 Anesthesiology, Heart Institute, Children's Hospital Colorado, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO, USA.

The correct selection and placement of a single-site Avalon Elite Dual Lumen Cannula for veno-venous extracorporeal membrane oxygenation (ECMO) in children weighing less than 20 kg is dependent on both the mechanical characteristics of the catheter, including length and diameter, as well as the unique vascular anatomic considerations of the patient. This manuscript describes the development of a clinical strategy, over a four-year period from 2012-2016, for cannula selection to reduce the risk of migration and malposition in 20 critically ill children weighing less than 20 kg who presented for veno-venous ECMO. Read More

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December 2018

Open chest epicardial and transapical endocardial substrate ablation for ventricular tachycardia with left ventricular aneurysm in a porcine model.

Perfusion 2018 Nov 16:267659118814689. Epub 2018 Nov 16.

1 Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Background:: Endo-epicardial radiofrequency catheter ablation (RFCA) of ventricular tachycardia (VT) as a first-line strategy has been shown to improve outcomes. This study sought to evaluate the feasibility and validity of open-chest epicardial and transapical endocardial substrate ablation for VT with left ventricular aneurysm (LVA) applying to routine cardiac surgery.

Methods:: Porcine models of LVA with VT were developed and were divided into a study group (RFCA from the epicardium via direct-view and endocardium via transapical access) and a control group (endocardial RFCA via retrograde transaortic access). Read More

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November 2018
3 Reads

Gender and intraoperative blood transfusion: analysis of 54,122 non-reoperative coronary revascularization procedures.

Perfusion 2018 Nov 16:267659118808728. Epub 2018 Nov 16.

SpecialtyCare, Nashville, TN, USA.

Background:: Previous studies have shown that women undergoing isolated coronary artery bypass graft (CABG) surgery have an increased risk for postoperative morbidity and mortality when compared to men. Additionally, recent evidence suggests that blood transfusions are independently associated with an increased risk of adverse outcome.

Methods:: We evaluated gender differences in the risk of intraoperative red blood cell (RBC) transfusion during CABG surgery. Read More

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November 2018
2 Reads

Long-term impact of critical silent cerebrovascular disease in patients undergoing coronary artery bypass surgery: a propensity score and multivariate analyses.

Perfusion 2018 Nov 16:267659118813042. Epub 2018 Nov 16.

2 Nippon Medical School Hospital, Tokyo, Japan.

Background:: Cerebrovascular disease (CVD) with brain hypoperfusion is a strong risk factor for stroke. However, how this pathology influences long-term outcomes after coronary artery bypass graft (CABG) surgery is not known.

Methods:: Magnetic resonance imaging/angiography (MRI/A) of the neck and brain was performed in 318 out of 575 consecutive CABG patients between May 2005 and April 2018. Read More

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November 2018
2 Reads

Prognostic impact of blood product transfusion in VA and VV ECMO.

Perfusion 2018 Nov 16:267659118814690. Epub 2018 Nov 16.

1 Department of Vascular and Cardio-Thoracic Surgery, Rennes University Hospital, Rennes, France.

Background:: Extracorporeal membrane oxygenation (ECMO) is an accepted and reliable technique to provide temporary circulatory and/or respiratory support. Our objective was to describe the transfusion requirements in ECMO recipients. Secondarily, we addressed the effect of indications for ECMO on transfusion requirements and the baseline factors associated with worse survival. Read More

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November 2018
6 Reads

Retrospective analysis of cardiac index and lactate production on cardiopulmonary bypass for a congenital cardiac patient population.

Perfusion 2018 Nov 14:267659118813076. Epub 2018 Nov 14.

Department of Cardiovascular Perfusion, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Background:: Providing adequate metabolic support is the principal concern during cardiopulmonary bypass (CPB) with different strategies utilized to enhance oxygen delivery to the patient. Modifying temperature, hematocrit (Hct) and cardiac index (CI) during CPB are primary techniques which aid in this effort. Based upon surgeon preference, the study institution employs differing perfusion strategies (PS) during congenital cardiac surgery requiring CPB. Read More

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November 2018
1 Read

Inferior vena cava stenosis after heart transplant: a rare cause of venoarterial extracorporeal membrane oxygenation weaning failure.

Perfusion 2018 Nov 3:267659118808731. Epub 2018 Nov 3.

Service d'Anesthésie et Réanimation du Groupement Hospitalier Est (GESTAR), Hospices Civils de Lyon, Lyon, France.

Introduction:: The discontinuation of venoarterial extracorporeal membrane oxygenation (VA ECMO) is a critical step in patient recovery. To reduce risks, weaning trials must be performed to buttress this important decision. However, a successful weaning trial does not preclude the possibility of complications. Read More

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November 2018
6 Reads

Development of a fluid-structure interaction model to simulate mitral valve malcoaptation.

Perfusion 2018 Nov 3:267659118811045. Epub 2018 Nov 3.

4 Department of Mechanical Engineering, University of Birmingham, Birmingham, UK.

Object:: Mitral regurgitation (MR) is a condition in which the mitral valve does not prevent the reversal of blood flow from the left ventricle into the left atrium. This study aimed at numerically developing a model to mimic MR and poor leaflet coaptation and also comparing the performance of a normal mitral valve to that of the MR conditions at different gap junctions of 1, 3 and 5 mm between the anterior and posterior leaflets.

Results:: The results revealed no blood flow to the left ventricle when a gap between the leaflets was 0 mm. Read More

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November 2018
5 Reads

Aortic valve replacement with or without myocardial revascularization in octogenarians. Can minimally invasive extracorporeal circuits improve the outcome?

Perfusion 2018 Nov 3:267659118811048. Epub 2018 Nov 3.

1 Department of Thoracic and Cardiovascular Surgery, Klinikum Braunschweig, Braunschweig, Germany.

Objective:: The positive impact of minimally invasive extracorporeal circuits (MiECC) on patient outcome is expected to be most evident in patients with limited physiologic reserves. Nevertheless, most studies have limited their use to low-risk patients undergoing myocardial revascularization. As such, there is little evidence to their benefit outside this patient population. Read More

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November 2018
3 Reads

Extracellular histones indicate the prognosis in patients undergoing extracorporeal membrane oxygenation therapy.

Perfusion 2018 Oct 29:267659118809557. Epub 2018 Oct 29.

1 Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, P.R. China.

Introduction:: Extracellular histones have been recently identified as damage-associated molecular-pattern (DAMP) molecules involved with the pathogenesis of various inflammatory diseases. This study intended to investigate whether extracellular histones can indicate the prognosis in critically ill patients supported by extracorporeal membrane oxygenation (ECMO) therapy.

Methods:: A total of 56 patients undergoing ECMO were analysed retrospectively. Read More

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October 2018
2 Reads

Extracorporeal membrane oxygenation simulation-based training: methods, drawbacks and a novel solution.

Perfusion 2018 Oct 19:267659118802749. Epub 2018 Oct 19.

3 Ambulance Service, Hamad Medical Corporation, Doha, Qatar.

Introduction: Patients under the error-prone and complication-burdened extracorporeal membrane oxygenation (ECMO) are looked after by a highly trained, multidisciplinary team. Simulation-based training (SBT) affords ECMO centers the opportunity to equip practitioners with the technical dexterity required to manage emergencies. The aim of this article is to review ECMO SBT activities and technology followed by a novel solution to current challenges. Read More

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October 2018
1 Read

Assessment of three methods for removing massive air in a cardiopulmonary bypass circuit: simulation-based multi-discipline training in West China Hospital.

Perfusion 2018 Oct 19:267659118806120. Epub 2018 Oct 19.

Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.

Background And Objective: A multi-discipline cardiac and cardiopulmonary bypass (CPB) team simulation scenario was established to compare three different de-airing approaches dealing with massive air embolism in CPB, so as to formulate a standardized procedure to handle this adverse acute event more proficiently and ensure clinical safety.

Method: A simulation-based clinical CPB massive air embolism scenario was developed by a cardiac and CPB team. Study Objects: Five licensed perfusionists and five CPB trainees were matched randomly into five pairs. Read More

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October 2018
1 Read

Large mediastinal neoplasm penetrating the myocardium.

Perfusion 2018 Oct 5:267659118803823. Epub 2018 Oct 5.

3 Emergency Medicine Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.

A 90-year-old female patient presented to the emergency department with abdominal pain. Computed tomography (CT) set the suspicion of a cardiac tumor in the right heart chambers. We describe the presentation, the differential diagnosis and the decision for management of the patient. Read More

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October 2018
1 Read

Pump-controlled retrograde trial off: considerations.

Perfusion 2018 Oct 5:267659118806452. Epub 2018 Oct 5.

4 Queensland Neonatal & Pediatric ECLS Service, Brisbane, Australia.

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October 2018

No-brainers in medicine.

Perfusion 2018 10;33(7):507-508

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October 2018
1 Read

Using thermochromism to simulate blood oxygenation in extracorporeal membrane oxygenation.

Perfusion 2018 Sep 7:267659118798140. Epub 2018 Sep 7.

3 Ambulance Service, Hamad Medical Corporation, Doha, Qatar.

Introduction: Extracorporeal membrane oxygenation (ECMO) training programs employ real ECMO components, causing them to be extremely expensive while offering little realism in terms of blood oxygenation and pressure. To overcome those limitations, we are developing a standalone modular ECMO simulator that reproduces ECMO's visual, audio and haptic cues using affordable mechanisms. We present a central component of this simulator, capable of visually reproducing blood oxygenation color change using thermochromism. Read More

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September 2018
1 Read

Intermittent upper and lower body perfusion during circulatory arrest is safe for aortic repair.

Perfusion 2018 Sep 5:267659118798178. Epub 2018 Sep 5.

1 Department of Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, The Mount Sinai Hospital, New York, NY, USA.

Introduction: We report our initial surgical experience of intermittent upper and lower body retrograde perfusion during aortic repair under circulatory arrest.

Methods: Between 2007 and 2015, 148 consecutive patients underwent surgical aortic repair using moderate hypothermic circulatory arrest with intermittent upper and lower body retrograde perfusion.

Results: All patients underwent ascending aorta replacement; eight had hemiarch replacement (5. Read More

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September 2018
1 Read

Concomitant aortic root and pectus deformity repair in Marfan syndrome patients.

Perfusion 2018 Aug 23:267659118794113. Epub 2018 Aug 23.

2 Department of Thoracic Surgery, L'Institut Mutualiste Montsouris, Paris, France.

The role of concomitant aortic and pectus repair in Marfan patients remains controversial. We present our surgical technique for concomitant aortic repair of aortic root pathology and pectus correction. The concomitant surgery can be safely achieved in Marfan patients, thus, avoiding the need for a risky second stage operation. Read More

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August 2018
5 Reads

The professional amateur and the amateurish professional.

Perfusion 2018 09;33(6):413-414

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September 2018
3 Reads
1.083 Impact Factor

Hemolytic characteristics of three suctioning systems for use with a newly developed cardiopulmonary bypass system.

Perfusion 2018 Aug 19:267659118793559. Epub 2018 Aug 19.

1 Department of Cardiovascular Surgery, Shinshu University School of Medicine, Matsumoto, Japan.

Introduction: We have been developing a closed-circuit cardiopulmonary bypass (CPB) system ("Dihead CPB") for application during coronary artery bypass grafting (CABG) and valve surgery. To strive for minimal hemolysis during Dihead CPB, we compared the hemolysis caused by three different suction systems and performed a clinical study with the newly applied suction system.

Materials & Methods: We evaluated the hemolysis caused by roller-pump suction, the SmartSuction Harmony and wall suction systems with respect to suction speed and compared the systems by means of in vitro studies. Read More

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August 2018
2 Reads

Increased blood transfusion and its impact in patients having tracheostomy while on extracorporeal membrane oxygenation.

Perfusion 2018 Aug 19:267659118795390. Epub 2018 Aug 19.

2 Department of Surgery, Division of Cardiothoracic Surgery, University of Kentucky, Lexington, KY, USA.

Introduction: Tracheostomy has been utilized in combination with venovenous extracorporeal membrane oxygenation (VV-ECMO) to enable early spontaneous breathing and minimize sedation requirements. Tracheostomy has been previously reported to be safe in patients supported on VV-ECMO; however, the impact of tracheostomy on blood loss in VV-ECMO patients is unknown.

Methods: We analyzed VV-ECMO patients with and without tracheostomy over a 5-year period. Read More

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August 2018
6 Reads

Cardiopulmonary bypass prime composition: beyond crystalloids versus colloids.

Perfusion 2018 Aug 16:267659118793249. Epub 2018 Aug 16.

2 Department of Public Health and Clinical Medicine, Heart Centre, Umeå University, Umeå, Sweden.

Introduction: In the literature addressing cardiopulmonary bypass (CPB) prime composition, there is a considerable lack of discussion concerning plasma osmolality changes induced by using a hyperosmolar prime. With this study, we try to determine the magnitude and temporal relationship of plasma osmolality changes related to the use of a hyperosmolar CPB prime.

Method: In this prospective observational study performed in a university hospital setting, we enrolled thirty patients scheduled for elective coronary bypass surgery. Read More

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August 2018
1 Read

Left ventricular unloading during veno-arterial ECMO: a review of percutaneous and surgical unloading interventions.

Perfusion 2018 Aug 16:267659118794112. Epub 2018 Aug 16.

4 ECMO Department, Karolinska University Hospital, Stockholm, Sweden.

Short-term mechanical support by veno-arterial extracorporeal membrane oxygenation (VA ECMO) is more and more applied in patients with severe cardiogenic shock. A major shortcoming of VA ECMO is its variable, but inherent increase of left ventricular (LV) mechanical load, which may aggravate pulmonary edema and hamper cardiac recovery. In order to mitigate these negative sequelae of VA ECMO, different adjunct LV unloading interventions have gained a broad interest in recent years. Read More

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August 2018
18 Reads

Cardioplegia practice in paediatric cardiac surgery: a UK & Ireland survey.

Perfusion 2018 Aug 10:267659118794343. Epub 2018 Aug 10.

1 Department of Paediatric Cardiac Surgery, Birmingham Children's Hospital, Birmingham, UK.

Introduction: Many techniques are available for cardioplegic arrest in children, but there is a lack of late phase clinical trials to guide practice. We surveyed paediatric cardiac surgeons and perfusionists to establish current practice and willingness to change within a clinical trial.

Methods: An online survey was sent to all consultant paediatric cardiac surgeons and chief perfusionists in paediatric centres in the UK and Ireland. Read More

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August 2018
5 Reads

Observation of local cardiac electrophysiological changes during off-pump coronary artery bypass grafting using epicardial mapping.

Perfusion 2018 Aug 2:267659118787664. Epub 2018 Aug 2.

1 Department of Cardiac Surgery, Capital Medical University Affiliated Anzhen Hospital, Beijing, People's Republic of China.

Objectives: At present, there is no effective method of evaluating the electrophysiological changes in cardiac myocytes during off-pump coronary artery bypass grafting (OPCAB). Therefore, we preliminarily explored the relationship between electrophysiological characteristics and the changes in cardiac function of 24 patients undergoing OPCAB.

Methods: We used the CARTO3 system for epicardial electrophysiological mapping before surgery, during left anterior descending branch anastomosis, diagonal branch anastomosis and after surgery for 24 patients undergoing OPCAB. Read More

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A comparison of haemostatic biomarkers during low-risk patients undergoing cardiopulmonary bypass using either conventional centrifugal cell salvage or the HemoSep device.

Perfusion 2018 Aug 1:267659118789051. Epub 2018 Aug 1.

5 Cardiothoracic Surgery/Cardiac Surgical Research, The Rayne Institute, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, UK.

Background: Cardiac surgery using cardiopulmonary bypass (CPB) is associated with a coagulopathy due to haemodilution, thrombocytopenia and platelet dysfunction and the activation of coagulation and fibrinolysis, despite the use of large doses of unfractionated heparin. Conventional red cell salvage may exacerbate post-operative bleeding as plasma containing haemostatic factors is discarded. We hypothesized that a novel cell salvage device (HemoSep) may attenuate haemostatic changes associated with red cell salvage. Read More

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August 2018
1 Read

Chronic venous insufficiency: a new concept to understand pathophysiology at the microvascular level - a pilot study.

Perfusion 2018 Aug 1:267659118791682. Epub 2018 Aug 1.

Vascular Department, Hammersmith Hospital, Imperial College London, London, UK.

Objectives: The real mechanism for the development of the later stages of chronic venous insufficiency still remains unclear. Venous hypervolemia and microvascular ischemia have been reported to be the consequences of venous insufficiency. The aim of this study was to investigate the effects of induced venous hypovolemia by dorsiflexion exercise in patients with venous leg ulcers. Read More

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August 2018
4 Reads

Left ventricular dysfunction after two hours of polarizing or depolarizing cardioplegic arrest in a porcine model.

Perfusion 2018 Jul 30:267659118791357. Epub 2018 Jul 30.

2 Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway.

Introduction: This experimental study compares myocardial function after prolonged arrest by St. Thomas' Hospital polarizing cardioplegic solution (esmolol, adenosine, Mg) with depolarizing (hyperkalaemic) St. Thomas' Hospital No 2, both administered as cold oxygenated blood cardioplegia. Read More

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July 2018
3 Reads

The effect of a novel turbulence-controlled suction system in the prevention of hemolysis and platelet dysfunction in autologous surgery blood.

Perfusion 2018 Jul 27:267659118790915. Epub 2018 Jul 27.

2 Department of Thoracic and Cardiovascular Surgery, University Medical Center Göttingen, Göttingen, Germany.

Background: Re-transfusion of autologous blood is an important aspect of intraoperative blood management. Hemolysis and platelet dysfunction due to turbulence in the blood suction system strongly impede later usage of suction blood for re-transfusion. The aim of this study was to analyze the effects of a novel surgical-blood suction system with an automatic control setup for minimization of turbulence in the blood flow. Read More

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July 2018
2 Reads

Extubation of patients undergoing extracorporeal life support. A retrospective study.

Perfusion 2018 Jul 25:267659118791072. Epub 2018 Jul 25.

1 Service d'Anesthésie Réanimation, CHU de Dijon, Dijon, France.

Introduction: The use of extracorporeal life support (ECLS) is increasing worldwide, in particular for the management of refractory cardiac arrest, cardiogenic shock and post cardiopulmonary bypass ventricular failure. Extubation of patients under extracorporeal membrane oxygenation (ECMO) for respiratory failure is a growing practice for adult and pediatric patients, especially for lung transplantation candidates. Because of potential complications and, specifically, accidental arterial decannulation, extubation of patients under ECLS is not standard practice. Read More

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July 2018
10 Reads

Blood cardioplegia benefits only patients with a long cross-clamp time.

Perfusion 2018 Jul 25:267659118790914. Epub 2018 Jul 25.

1 Department of Anaesthesia and Intensive Care, Aarhus University Hospital, Aarhus, Denmark.

Introduction: A clear advantage of blood versus crystalloid cardioplegia has not yet been observed in smaller population studies. The purpose of this article was to further investigate the clinical outcomes of blood versus crystalloid cardioplegia in a large propensity-matched cohort of patients who underwent cardiac surgery.

Methods: The study was a single-centre study. Read More

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July 2018
21 Reads

Protracted aortic valve closure during peripheral veno-arterial extracorporeal life support: is intra-aortic balloon pump an effective solution?

Perfusion 2018 Jul 1:267659118787426. Epub 2018 Jul 1.

1 Department of Cardio-Thoracic Surgery, Maastricht University Medical Centre (MUMC+), Maastricht, The Netherlands.

Background: Left ventricular (LV) afterload increase with protracted aortic valve (AV) closure may represent a complication of veno-arterial extracorporeal membrane oxygenation (V-A ECMO). The aim of the present study was to assess the effects of an intra-aortic balloon pump (IABP) to overcome such a hemodynamic shortcoming in patients submitted to peripheral V-A ECMO.

Methods: Among 184 adult patients who were treated with peripheral V-A ECMO support at Medical University Center Maastricht Hospital between 2007 and 2018, patients submitted to IABP implant for protracted AV closure after V-A ECMO implant were retrospectively identified. Read More

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July 2018
16 Reads

Impact of ex-vivo extracorporeal membrane oxygenation circuitry on daptomycin.

Perfusion 2018 11 18;33(8):624-629. Epub 2018 Jul 18.

1 The Center for Pediatric Pharmacotherapy LLC, Pottstown, PA, USA.

Background: The objective was to determine the alterations of daptomycin (DAP) in a contemporary neonatal/pediatric (1/4-inch) and adolescent/adult (3/8-inch) extracorporeal membrane oxygenation (ECMO) circuit including the Quadrox-i oxygenator.

Methods: Quarter-inch and 3/8-inch, simulated, closed-loop, ECMO circuits were prepared with a Quadrox-i pediatric and Quadrox-i adult oxygenator and blood primed. A one-time dose of DAP was administered into the circuit and serial pre- and post-oxygenator concentrations were obtained at 0-5 minutes and 1, 2, 3, 4, 5, 6 and 24-hour time points. Read More

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November 2018
14 Reads

Impact of education and training course for ECMO patients based on high-fidelity simulation: a pilot study dedicated to ICU nurses.

Perfusion 2018 Jul 1:267659118789824. Epub 2018 Jul 1.

7 Centre de Simulation Pytheas. Assistance Publique-Hôpitaux de Marseille, Marseille, France.

Introduction: Medical and para-medical education is one of the key points of healthcare strategy. Training and education based on high-fidelity simulation is one of the gold standards in modern healthcare institutions. We describe a model of training dedicated to ICU nurses in charge of patients with ECMO. Read More

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July 2018
1 Read

Extracorporeal membrane oxygenation in acute massive pulmonary embolism: a case series and review of the literature.

Perfusion 2018 Jul 1:267659118786830. Epub 2018 Jul 1.

3 Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.

Background: Extracorporeal membrane oxygenation (ECMO) has been used to stabilize patients with massive pulmonary embolism though few reports describe this approach. We describe the presentation, management and outcomes of patients who received ECMO for massive pulmonary embolism (PE) in our pulmonary embolism response team (PERT) registry.

Methods: We enrolled a consecutive cohort of patients with confirmed PE for whom PERT was activated and selected patients treated with ECMO. Read More

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July 2018
8 Reads

Increased Rho kinase activity in patients with heart ischemia/reperfusion.

Perfusion 2018 Jul 1:267659118787432. Epub 2018 Jul 1.

1 Department of Cardiology, The Second Hospital of Shandong University, Jinan, Shandong Province, China.

Background/aim: Rho kinase is a downstream effector of Rho GTPase that is known to regulate various pathological processes. The aim of this study was to evaluate the regulation of Rho kinase activity in leukocytes in patients with ischemia/reperfusion (I/R) injury.

Patients And Methods: We investigated 38 patients with acute ST-segment elevation myocardial infarction (STEMI), 26 patients with atherosclerosis (AS) and 22 normal subjects. Read More

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July 2018
19 Reads
1.080 Impact Factor

Microbiological monitoring of heater-cooler unit to keep free of Mycobacterium chimaera infection.

Perfusion 2018 Jul 1:267659118787152. Epub 2018 Jul 1.

1 National Heart Centre Singapore, Singapore.

Introduction: The association of Mycobacterium chimaera infection in patients undergoing cardiopulmonary bypass (CPB) with the use of heater-cooler units (HCU) has been reported in various literature. We described microbiological monitoring and the extent of microbiological contamination of HCUs utilized in our centre and strategies employed to reduce the high microbial load.

Methods: Since August 2016, we have been following the new Instructions for Use from the manufacturer for the cleaning and disinfection of three units of Stöckert 3T and four units of Stöckert 1T HCU at the National Heart Centre Singapore. Read More

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July 2018
1 Read

Impact of age on early outcomes and long-term survival of patients undergoing aortic repair with Stanford A dissection.

Perfusion 2018 11 11;33(8):687-695. Epub 2018 Jul 11.

Department of Cardiothoracic Surgery, University Hospital of Cologne, Cologne, Germany.

Objectives: Stanford A acute aortic dissection (AAD) is a life-threatening emergency, typically occurring in older patients and requiring immediate surgical repair. The aim of this study was to evaluate early outcome and short- and long-term survival of patients under and above 65 years of age.

Methods: Two hundred and forty patients with Stanford A AAD underwent aortic surgical repair from January 2006 to April 2015 in our center. Read More

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November 2018
10 Reads
1.080 Impact Factor

GSK-3β inhibition confers cardioprotection associated with the restoration of mitochondrial function and suppression of endoplasmic reticulum stress in sevoflurane preconditioned rats following ischemia/reperfusion injury.

Perfusion 2018 11 10;33(8):679-686. Epub 2018 Jul 10.

1 Intensive Care Unit, Shanghai Jing'an District Shibei Hospital, Shanghai, 200040, China.

Background: Sevoflurane has been shown to protect against myocardial ischemia/reperfusion (I/R) injury in animals, while its cardioprotection is lost if the ischemic insult is too long. In this study, we proposed a prevailing hypothesis that GSK-3β inhibitor-mediated activation of GSK-3β/β-catenin signaling pathway provides additional cardioprotection in sevoflurane preconditioned rats following I/R injury.

Methods: Rats were subjected to treatment with TDZD-8, a GSK-3β inhibitor, 5 minutes prior to sevoflurane preconditioning and 30-minute ischemia and 120-minute reperfusion. Read More

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November 2018
5 Reads

A modified procedure in aortic arch replacement with no deep hypothermic circulatory arrest.

Perfusion 2018 11 2;33(8):663-666. Epub 2018 Jul 2.

1 Department of Cardiovascular Surgery, Linyi Municipal People's Hospital, Linyi, China.

Deep hypothermia or circulation arrest is widely used during total aortic arch replacement. However, conventional procedures have high morbidity and mortality. We use the "branch-first" technique combined with clamping the distal aorta, incorporating a stented elephant trunk to avoid deep hypothermia and circulation arrest. Read More

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November 2018
2 Reads

The Norwood Stage 1 procedure - conduct of perfusion: 2017 Survey results from NPC-QIC member institutions.

Perfusion 2018 11 2;33(8):667-678. Epub 2018 Jul 2.

5 Division of Cardiothoracic Surgery Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Hypoplastic left heart syndrome (HLHS) is a rare and severe congenital cardiac defect. Approximately 1000 infants are born with HLHS in the United States every year. Healthcare collaboratives over the last decade have focused on sharing patient experiences and techniques in an effort to improve outcomes. Read More

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November 2018

Effect of inflow cannula side-hole number on drainage flow characteristics: flow dynamic analysis using numerical simulation.

Perfusion 2018 11 29;33(8):649-655. Epub 2018 Jun 29.

1 Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Background: Venous drainage in cardiopulmonary bypass is a very important factor for safe cardiac surgery. However, the ideal shape of venous drainage cannula has not been determined. In the present study, we evaluated the effect of side-hole number under fixed total area and venous drainage flow to elucidate the effect of increasing the side-hole numbers. Read More

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November 2018

Unique static discharge events on two CentriMag (2 Gen) ECMO patients causing console failure.

Perfusion 2018 11 29;33(8):707-710. Epub 2018 Jun 29.

1 Penn State Hershey Medical Center, Penn State Health, Hershey, PA, USA.

The use of ECMO for cardiovascular support continues to increase in the United States and around the world. It is not a benign endeavor as serious complications may occur. We present our experience of two second generation CentriMag (Abbott formerly Thoratec Inc. Read More

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November 2018
1 Read

The influence of oxygen delivery during cardiopulmonary bypass on the incidence of delirium in CABG patients; a retrospective study.

Perfusion 2018 11 29;33(8):656-662. Epub 2018 Jun 29.

1 Erasmus MC, Rotterdam, The Netherlands.

Introduction: Postoperative delirium is the most common neurological complication of cardiac surgery. Hypoxia has been shown to increase the risk of postoperative delirium. The possibility to continuously monitor oxygen delivery (DO) during cardiopulmonary bypass (CPB) offers an adequate approximation of the oxygen status in a patient. Read More

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November 2018
1 Read

Clear Persuasion.

Authors:
Mark Kurusz

Perfusion 2018 07;33(5):334

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July 2018
4 Reads

Does the type of cardioplegia used during valve surgery influence operative nadir hematocrit and transfusion requirements?

Perfusion 2018 11 6;33(8):638-648. Epub 2018 Jun 6.

SpecialtyCare, Nashville, TN, USA.

Introduction: Myocardial protection is performed using diverse cardioplegic (CP) solutions with various combinations of chemical and blood constituents. Newer CP formulations that extend ischemic intervals may require greater asanguineous volume, contributing to hemodilution.

Methods: We evaluated intraoperative hemodilution and red blood cell (RBC) transfusion rates among three common CP solutions during cardiac valve surgery. Read More

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November 2018
6 Reads

Prolonged use of eptifibatide as a bridge to maintain drug-eluting stent patency in a patient receiving extracorporeal membrane oxygenation.

Perfusion 2018 11 6;33(8):699-703. Epub 2018 Jun 6.

2 Department of Cardiovascular and Thoracic Surgery, Rush University Medical Center, Chicago, IL, USA.

Background: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been used as a bridge to cardiac recovery in patients following a major cardiac event. There is a lack of literature surrounding prolonged use of eptifibatide and optimal dosing during ECMO. This case report describes our experience with extended durations and standard dosing of eptifibatide in the setting of ECMO. Read More

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November 2018
8 Reads