7,135 results match your criteria Perforated Peptic Ulcer


Investigation the levels of endotoxin and 8-hydroxy-2'-deoxyguanosine in sera of patients with Helicobacter pylori positive peptic ulcer.

Int J Clin Pract 2021 Jun 12:e14501. Epub 2021 Jun 12.

Harran University, Faculty of Medicine, Dept. of Medical Biochemistry, Şanlıurfa.

Background: Peptic ulcer is considered an important public health problem and generally associated with complicated conditions such as bleeding and perforation. The aim of this study is to reflect the rate of oxidative damage in the body among dyspeptic patients with H. pylori-positive peptic ulcer by measuring 8-hydroxy-2'-deoxyguanosine (8-OHdG) level in serum samples and its association with the level of bacterial endotoxin. Read More

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A case report of gastric volvulus, a rare cause of acute abdomen.

Radiol Case Rep 2021 Jul 26;16(7):1907-1911. Epub 2021 May 26.

Radiology Department of Hospital Universiti Kebangsaan Malaysia, UKM. Kuala Lumpur, Malaysia.

Gastric volvulus is an uncommon disorder with an unknown incidence, unless it stays in the back of the diagnostician's mind, diagnosis of gastric volvulus, which can have significant morbidity and mortality associated with it, can be easily missed and can present either in the acute or chronic setting with variable symptoms. When it occurs in the acute scenario, patients present with severe epigastric pain and retching without vomiting. Together with inability to pass nasogastric tube, they constitute Borchardt's triad. Read More

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Primary closure versus Graham patch omentopexy in perforated peptic ulcer: A systematic review and meta-analysis.

Surgeon 2021 Jun 2. Epub 2021 Jun 2.

Department of General and Colorectal Surgery, Good Hope Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Background: There are different methods to repair a perforated peptic ulcer, the two most frequently used are the Graham patch omentopexy and the primary closure. Currently there is no high-level evidence to provide guidance of the optimal method of repair. The aim of this study is to compare the outcomes of the two methods so as to provide improved guidance for surgeons undertaking this repair. Read More

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Empiric antifungals do not decrease the risk for organ space infection in patients with perforated peptic ulcer.

Trauma Surg Acute Care Open 2021 19;6(1):e000662. Epub 2021 May 19.

Department of Surgery, Texas Tech University Health Sciences Center School of Medicine-Lubbock Campus, Lubbock, Texas, USA.

Introduction: Infection control in patients with perforated peptic ulcers (PPU) commonly includes empiric antifungals (AF). We investigated the variation in the use of empiric AF and explored the association between their use and the subsequent development of organ space infection (OSI).

Methods: This was a secondary analysis of a multicenter, case-control study of patients treated for PPU at nine institutions between 2011 and 2018. Read More

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Complicated Ventral Hernia: A Perquisite for Perforated Peptic Ulcer-Unusual Clinical Scenario.

Surg J (N Y) 2021 Apr 25;7(2):e66-e68. Epub 2021 May 25.

Department of General Surgery, Seth G.S. Medical College & KEM Hospital, Parel, Mumbai, Maharashtra, India.

 Peptic ulcer usually presents to the emergency in the form of an acute abdomen, which is usually diagnosed easily either clinically or radiologically. Although its incidence has decreased with the introduction on proton pump inhibitors it is still one of the most common emergencies encountered by a surgeon.  A 60-year-old woman complained of epigastric swelling for 6 months which gradually increased and became irreducible over the last 2 months. Read More

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A Fast and Reliable Method to Interpret Short-Term Mortality in Perforated Peptic Ulcer: Red Cell Distribution Width is Sensitive and Specific.

Surg Res Pract 2021 18;2021:5542619. Epub 2021 May 18.

Department of Surgery, University of Health Sciences, Haseki Training and Research Hospital, Istanbul, Turkey.

Introduction: Peptic ulcer is an important health problem worldwide with a prevalence of around 5%. Peptic ulcer perforation is a potentially mortal complication of peptic ulcer disease. We aimed to investigate the potential use of red cell distribution width as a prognostic marker in peptic ulcer perforation. Read More

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Surgery for Perforated Peptic Ulcer: Is Laparoscopy a New Paradigm?

Minim Invasive Surg 2021 12;2021:8828091. Epub 2021 May 12.

General Surgery Department, São João University Medical Center, Porto, Portugal.

Introduction: Laparoscopic repair of perforated peptic ulcer (PPU) remains controversial mainly due to its safety and applicability in critically ill patients. The aim of this study is to compare the outcomes of laparoscopy versus laparotomy in the treatment of PPU.

Methods: Single-institutional, retrospective study of all patients submitted to surgical repair of PPU between 2012 and 2019. Read More

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Subhepatic appendix: an ectopic topography not to be disregarded: a case report.

J Med Case Rep 2021 May 31;15(1):288. Epub 2021 May 31.

Department of Surgery, Regional Hospital Center of Maradi, Faculty of Health Sciences of the University of Maradi, Maradi, Niger.

Introduction: Subhepatic appendix is most often due to an anomaly of rotation of the primary intestine occurring during embryogenesis. This ectopic topography associated with advanced age can be a serious diagnosis problem at the stage of appendicitis or appendicular peritonitis.

Case Presentation: We report the case of a 60-year-old melanoderm man, with a history of urinary pathology and peptic ulcer, referred from a health district for abdominal pain of the right hypochondrium evolving for about 5 days, secondarily generalized, in whom we suspected peritonitis, the etiology of which remains to be determined. Read More

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Analysis of risk factors affecting the development of peptic ulcer perforation: case-control study.

Prz Gastroenterol 2021 25;16(1):23-28. Epub 2020 Apr 25.

Department of Surgery and Liver Transplant Institute, Faculty of Medicine, Inonu University, Malatya, Turkey.

Aim: The aim of the to determine the risk factors associated with increased risk of peptic ulcer perforation (PUP).

Material And Methods: The demographic, clinic, and biochemical parameters of 65 patients (PUP group) who underwent PUP surgery at our clinic between June 2009 and September 2016 were compared with the data of 134 patients (control group) who underwent endoscopy at a gastroenterology clinic for dyspeptic complaints. The control group were matched at random in a 1 : 2 ratio with the PUP group. Read More

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[Endoscopic Hemostasis and Its Related Factors of Duodenal Hemorrhage].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2021 Apr;43(2):222-229

Department of Gastroenterology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

Objective To analyze clinical characteristics and short-term efficacy of endoscopic hemostasis in acute duodenal hemorrhage. Methods A retrospective study was conducted for the patients who received endoscopy in the PUMC Hospital due to upper gastrointestinal bleeding and were confirmed to be on account of duodenal lesions for bleeding from January 2011 to December 2018.Clinical information of patients was collected,including demographics,comorbidities,and medication use. Read More

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Clinical Characteristics of Primary Repair for Perforated Peptic Ulcer: 10-Year Experience in a Single Center.

J Clin Med 2021 Apr 20;10(8). Epub 2021 Apr 20.

Department of Surgery, Inha University Hospital, College of Medicine, Jung-gu, Inchon 22332, Korea.

Background: Perforated peptic ulcer (PPU) is a disease whose incidence is decreasing. However, PPU still requires emergency surgery. The aim of this study was to review the clinical characteristics of patients who received primary repair for PPU and identify the predisposing factors associated with severe complications. Read More

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Risk Factors that Affect Morbidity and Mortality in Patients with Perforated Peptic Ulcer Diseases in a Teaching Hospital.

Ethiop J Health Sci 2020 Jul;30(4):549-558

Cardiothoracic Unit, Department of Surgery, School of Medicine, College of Health Sciences, Addis Ababa University, Ethiopia.

Background: This study was done to identify risk factors that affect the morbidity and mortality of patients operated for a perforated peptic ulcer in a resource-limited setting.

Methods: A two years (January 1, 2016 -December 30, 2018) retrospective cross-sectional study was done on patients admitted and operated for PPU at Yekatit 12 Hospital, Addis Ababa, Ethiopia.

Results: A total of 93 patients were operated. Read More

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Surgical Management of Peptic Perforation in a Tertiary Care Center: A Retrospective Study.

Niger Med J 2020 Nov-Dec;61(6):328-333. Epub 2020 Dec 19.

Department of General Surgery, Midnapore Medical College, West Midnapore, West Bengal, India.

Background: The purpose of this study is to estimate disease burden, clinical features, and outcome in the emergency surgical management of peptic perforation in a rural government tertiary care center where patients are socioeconomically very poor and also impacted by lack of good quality health-care facility.

Materials And Methods: The study had retrospectively analyzed 121 patients with peptic perforation who had undergone emergency laparotomy at Midnapore medical college, West Bengal, India, from June 2018 to December 2019. All patients >12 years were included in this study. Read More

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December 2020

Acupoint catgut embedding for the treatment of peptic ulcers: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25562

Jiangxi University of Traditional Chinese Medicine.

Background: Peptic ulcer (PU) is a common clinical disease of the digestive system, which can occur in all ages, gastric and duodenal ulcers are the most commonly seen PUs in clinical practice. The main manifestations are chronic and periodic rhythmic upper abdominal pain, accompanied by indigestion symptoms such as pantothenic acid, belching, and nausea. Serious complications such as bleeding, perforation, obstruction and canceration are easy to occur, endangering the life safety of patients. Read More

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Outcomes of Laparoscopic vs Open Repair of Perforated Peptic Ulcers: An ACS-NSQIP Study.

J Surg Res 2021 Apr 14;265:13-20. Epub 2021 Apr 14.

Anne Arundel Medical Center, Annapolis, Maryland. Electronic address:

Background: Perforated peptic ulcer (PPU) is a surgical emergency needing swift operative resolution. While laparoscopic and open approaches are viable options, it remains unclear whether laparoscopic repair has significantly improved outcomes. We use a national surgical database to compare perioperative and 30-d postoperative (30POP) outcomes. Read More

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Gastric Antral Diverticula: A Rare Diverticula with a Unique Presentation.

Case Rep Gastrointest Med 2021 26;2021:6623183. Epub 2021 Mar 26.

Department of Internal Medicine, Grand Strand Medical Center, Myrtle Beach, SC, USA.

Gastric diverticula are the least common gastrointestinal diverticula. Patients can be diagnosed incidentally on EGD or present with variable symptoms such as abdominal fullness, anorexia, and perforation. Gastric diverticula can be acquired from malignancy, peptic ulcer disease, or prior surgery or be congenital. Read More

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Perforated gastric ulcer as the initial manifestation of hyperparathyroidism.

BMJ Case Rep 2021 Apr 13;14(4). Epub 2021 Apr 13.

General Surgery, Hutt Valley District Health Board, Lower Hutt, New Zealand.

Primary hyperparathyroidism is characterised by autonomous production of parathyroid hormone resulting in hypercalcaemia. It is estimated that 12% of these patients present with peptic ulcer-related symptoms. The pathophysiological mechanism is not well established, but studies reveal serum calcium activating gastrin cell calcium receptors ultimately resulting in increased gastric acid production leading to peptic ulcer disease. Read More

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Outcomes of Nonoperative Treatment for Gastroduodenal Ulcer Perforation: a Nationwide Study of 14,918 Inpatients in Japan.

J Gastrointest Surg 2021 Apr 6. Epub 2021 Apr 6.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Gastroduodenal ulcer perforation is a common abdominal emergency that may be curable without surgical repair in non-elderly patients with localized and stable symptoms. However, the outcomes of nonoperative approaches have rarely been described.

Methods: Using a Japanese national inpatient database, we identified 14,918 patients with gastroduodenal ulcer perforation who were hospitalized and received nonoperative treatment from July 2010 to March 2017. Read More

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Platelet to Lymphocyte Ratio Associated with Prolonged Hospital Length of Stay Postpeptic Ulcer Perforation Repair: An Observational Descriptive Analysis.

Biomed Res Int 2021 9;2021:6680414. Epub 2021 Mar 9.

Department of Surgery, Trauma Surgery, Hamad Medical Corporation, Doha, Qatar.

Background: The predictive role of platelet to lymphocyte ratio (P/LR) in patients with perforated peptic ulcer (PPU) is not well-studied. We aimed to investigate the association between the P/LR ratio and the hospital length of stay (HLOS) for surgically treated PPU.

Method: This is a retrospective observational study for surgically treated adult cases of PPU at Hamad Medical Corporation during the period from January 2012 to August 2017. Read More

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Spontaneous esophageal rupture following perforated peptic ulcer: a report of two cases.

J Cardiothorac Surg 2021 Mar 26;16(1):57. Epub 2021 Mar 26.

Division of Thoracic Surgery, Department of Surgery, Changhua Christian Hospital, No. 135 Nanxiao St., Changhua City, Changhua County, 500, Taiwan.

Background: Spontaneous esophageal rupture, also called Boerhaave's syndrome, is relatively uncommon but may result in high morbidity and mortality. Synchronous presentation of spontaneous esophageal rupture and perforated peptic ulcer was rare and may contribute to the difficulty of achieving a correct diagnosis.

Case Presentation: We reported two patients with spontaneous esophageal rupture following perforated peptic ulcer. Read More

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Non-steroidal anti-inflammatory drugs and the gastrointestinal tract.

Clin Med (Lond) 2021 03;21(2):131-134

Royal Hallamshire Hospital, Sheffield, UK.

Non-steroidal anti-inflammatory drugs (NSAIDs) are used commonly but can cause foregut symptoms, peptic ulcer disease and small bowel enteropathy. Such iatrogenic injury can be complicated by gastrointestinal bleeding and perforation. Limiting NSAID use or co-administration with proton pump inhibitors (PPIs) reduce dyspepsia, peptic ulcer disease and rates of complications. Read More

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Operative experience in essential emergency general surgery procedures: is autonomy achievable during surgical training?

ANZ J Surg 2021 Jun 22;91(6):1131-1137. Epub 2021 Mar 22.

Department of Surgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Background: Readiness for practice is an ongoing concern in surgery. Surgeons who have completed general surgery training are expected to be proficient in performing common emergency procedures. The aim of this study was to assess the experience and autonomy of general surgery trainees in New Zealand in 10 emergency general surgery procedures, and identify factors associated with reaching primary operator (PO) thresholds. Read More

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Duet laparoscopic repair with knotless barbed sutures for treatment of perforated peptic ulcer: reality in general surgery with lacking of manpower.

Ann Transl Med 2021 Feb;9(4):311

Department of Surgery, Dankook University College of Medicine, Chungnam, Republic of Korea.

Background: Perforated peptic ulcer (PPU) is a fatal complication of peptic ulcer disease, which requires emergency surgery. Laparoscopic repair is the widely accepted and effective method for the treatment of PPU. The aim of this study was to evaluate the safety and efficacy of duet laparoscopic repair of PPU with knotless barbed sutures. Read More

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February 2021

Gastric Perforation Secondary to Fungal Gastritis in an Immuno-Competent Adult.

Cureus 2021 Feb 5;13(2):e13156. Epub 2021 Feb 5.

Pathology, National Institute of Pathology, New Delhi, IND.

Gastrointestinal (GI) tract perforation is a surgical emergency. The epidemiology and etiology of perforation vary considerably across geography. Lower GI tract perforations in the elderly predominate in the West compared to upper GI perforations in the younger population in the tropics. Read More

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February 2021

Protective and therapeutic effects of the flavonoid "pinocembrin" in indomethacin-induced acute gastric ulcer in rats: impact of anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms.

Naunyn Schmiedebergs Arch Pharmacol 2021 Feb 27. Epub 2021 Feb 27.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.

Peptic ulcer including gastric and duodenal ulcers is a common gastro-intestinal disorder worldwide, associated with a significant mortality due to bleeding and perforation. Numerous efforts are being exerted to look for natural drugs that lack the potential side effects but still keep beneficial effects for treatment and/or prevention of gastric ulcer. Pinocembrin (PINO) is a natural flavonoid retaining anti-microbial, anti-oxidant, and anti-inflammatory activities. Read More

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February 2021

Evidence-based clinical practice guidelines for peptic ulcer disease 2020.

J Gastroenterol 2021 Apr 23;56(4):303-322. Epub 2021 Feb 23.

Guidelines Committee for Creating and Evaluating the ''Evidence-Based Clinical Practice Guidelines for Peptic Ulcer," the Japanese Society of Gastroenterology (JSGE), 6F Shimbashi i-MARK Bldg., 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, Japan.

The Japanese Society of Gastroenterology (JSGE) revised the third edition of evidence-based clinical practice guidelines for peptic ulcer disease in 2020 and created an English version. The revised guidelines consist of nine items: epidemiology, hemorrhagic gastric and duodenal ulcers, Helicobacter pylori (H. pylori) eradication therapy, non-eradication therapy, drug-induced ulcers, non-H. Read More

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Optimal treatment and complications of patients with the perforated upper gastrointestinal tract.

Surg Today 2021 Feb 20. Epub 2021 Feb 20.

Department of Surgery, Kinan Hospital, 46-70 Shinjo, Tanabe, Wakayama, 646-8588, Japan.

Purpose: The perforation of the upper gastrointestinal tract is still associated with a high risk of complications and mortality. We aimed to evaluate the optimal treatment and post-treatment complications for this condition.

Methods: This was a retrospective, single-center study conducted between 2010 and 2019. Read More

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February 2021

Risk factors influencing postoperative outcome in patients with perforated peptic ulcer: a prospective cohort study.

Eur J Trauma Emerg Surg 2021 Feb 15. Epub 2021 Feb 15.

Department of Surgery, JN Medical College, AMU, Aligarh, UP, 202002, India.

Background: Perforated peptic ulcer (PPU) has been associated with substantially high incidence of morbidity and mortality. The aim of this study was to analyze the factors affecting the outcome of patients having perforated peptic ulcer undergoing surgical intervention.

Materials And Methods: Medical records of 112 patients with PPU who underwent emergency laparotomy between December 2014 and November 2016 were prospectively analyzed. Read More

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February 2021

[Open and laparoscopic surgery via minimally invasive approach in the treatment of perforated ulcer: a systematic review and metaanalysis].

Khirurgiia (Mosk) 2021 (2):94-100

Vishnevsky National Medical Research Center of Surgery, Moscow, Russia.

Objective: Systematic review and metaanalysis of the effectiveness of open and minimally invasive laparoscopic suturing of perforated peptic ulcer.

Material And Methods: Searching for Russian and English language reports included Scientific Electronic Library, Cochrane Collaboration Library and PubMed databases. We have analyzed contents of specialized journals, reviews and their references. Read More

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February 2021