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Sci Rep 2022 Jun 17;12(1):10243. Epub 2022 Jun 17.

Department of General, Visceral and Transplant Surgery, University Hospital of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

Surgical therapy of duodenal perforation into the retroperitoneum entails high morbidity. Conservative treatment and endoscopic negative pressure therapy have been suggested as promising therapeutic alternatives. We aimed to retrospectively assess outcomes of patients treated for duodenal perforation to the retroperitoneum at our department. Read More

BMC Surg 2022 Jun 16;22(1):230. Epub 2022 Jun 16.

Department of Surgery, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, 77 Sakju-ro, 24253, Chuncheon, Korea.

Background: Perforated peptic ulcer (PPU) is a common emergency condition requiring surgery using laparoscopy or open repair of the perforated site. The aim of this study was to assess the role of laparoscopic surgery (LS) based on the safety and efficacy for PPU.

Methods: Medical records of the consecutive patients who underwent LS or open surgery (OS) for PPU at five hospitals between January 2009 and December 2019 were retrospectively reviewed. Read More

J Pharm Pract 2022 Jun 15:8971900221108716. Epub 2022 Jun 15.

Department of Pharmacy Practice and Administration, 242956Wegmans School of Pharmacy at St John Fisher College, Rochester, NY, USA.

The high morbidity and mortality rates associated with invasive fungal infections have led to the overutilization of empiric antifungal therapies. With increasing antibiotic resistance, the careful consideration of prophylactic or empiric antifungal use is critical. The purpose of this review is to evaluate the available literature regarding the current practice of utilizing antifungal agents for intra-abdominal infections based on specific surgical procedures and patient risk factors. Read More

Med Trop Sante Int 2021 12 26;1(4). Epub 2021 Nov 26.

Département de chirurgie et spécialités, Faculté de médecine et des sciences biomédicales de l'Université de Yaoundé I, Cameroun.

Objective: Acute non-traumatic digestive surgical emergencies are a frequent cause of emergency in Africa. We undertook this study to investigate the morbidity and mortality of these patients in Cameroon, a developing country in Central Africa.

Patients And Methodology: This was an analytical cross-sectional study with prospective data collection, over a period of eight months (November 2019 to July 2020), at the Yaoundé central hospital (Cameroon). Read More

Ulus Travma Acil Cerrahi Derg 2022 Jun;28(6):762-768

Department of General Surgery, University of Health Sciences, Gülhane Training and Research Hospital, Ankara-Turkey.

Background: Upper gastrointestinal system bleeding (UGIB) that occurs with the effect of coagulopathy due to COVID-19 disease itself and drugs such as LMWH and steroids used in the treatment negatively affects the outcomes. In this study, we aimed to examine the frequency of gastrointestinal system bleeding in COVID-19 patients, risk factors, effect on outcomes, and management.

Methods: Institutional center (a third-level pandemic center) database was searched for patients hospitalized for COVID-19 between March 11, 2020, and December 17, 2020, retrospectively. Read More

BMJ Case Rep 2022 Jun 1;15(6). Epub 2022 Jun 1.

Department of Urology, Wagga Wagga Base Hospital, Wagga Wagga, New South Wales, Australia.

Duodenal diverticulum perforation is a rare and life-threatening pathology. Perforation secondary to iatrogenic causes is rare, with only 14 cases previously reported. This paper explores a world-first case report on iatrogenic duodenal diverticulum perforation during right laparoscopic nephroureterectomy and a systematic review of all reported cases of duodenal diverticulum perforation in the literature. Read More

Rev Esp Enferm Dig 2022 May 31. Epub 2022 May 31.

Gastroenterología y Endoscopia Digestiva, Hospital Universitario UANL, México.

A 32-year-old male with crack-cocaine abuse for 10 years, 300 g/day. He started with epigastric abdominal pain, intensity 10/10, he went to another hospital where a perforated peptic ulcer was suspected and a laparotomy was performed, with no findings. Subsequently, he started with vomiting and weight loss, on admission, a gastric outlet obstruction (GOO) was suspected and CT scan showed a concentric duodenal growth. Read More

J Coll Physicians Surg Pak 2022 Apr;32(4):S21-S23

Department of General Surgery, Nishtar Hospital, Multan, Pakistan.

Peptic ulcer disease affects a large number of people around the world. Complications occur in 10-20% of patients and perforation develops in 2-14% of the cases. It can either be in the pyloric part of the stomach or in the first part of duodenum. Read More

J Pak Med Assoc 2022 Apr;72(4):755-757

Department of Surgery, Mayo Hospital, Lahore, Pakistan.

A 57 years old male presented in the emergency department of EAST Surgical Ward, MAYO Hospital Lahore in February 2021 with complaints of abdominal distension, pain and vomiting. He was a chronic smoker and diagnosed hypertensive for the last 14 years but was non-compliant with oral antihypertensive medications. He was a factory worker and took NSAIDs off and on for pain in the knee joint for the last five years. Read More

World J Emerg Surg 2022 05 24;17(1):24. Epub 2022 May 24.

Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background: Peptic ulcer perforation is a common life-threatening surgical emergency. Graham omental patch is performed for plugging of perforated peptic ulcer. Many endoscopic methods have been used to treat acute perforated peptic ulcer such as over the scope clips, standard endoscopic clips, endoscopic sewing and metallic stents. Read More

Cureus 2022 Apr 15;14(4):e24159. Epub 2022 Apr 15.

Surgery, Hayat Memorial Teaching Hospital, Lahore, PAK.

Background Perforation of peptic ulcers is a common cause of emergency surgery and has significant morbidity and mortality. The use and range of laparoscopic surgery have greatly increased over the past three decades. Laparoscopic approach is an option for perforated peptic ulcers because of the simple nature of the intervention. Read More

World J Emerg Surg 2022 05 16;17(1):23. Epub 2022 May 16.

Department of General Surgery, İzmir Tepecik Training and Research Hospital, İzmir, Turkey.

Background: Perforated peptic ulcer is a common surgical emergency condition worldwide, which is associated with significant morbidity and mortality if early diagnosis and immediate surgical management were not carried out. Perforation occurs in roughly 5% of PUD patients during their lifetime; this study aimed to explore the wide range of clinical presentations, associated risk factors, complications, and surgical management of perforated peptic ulcer patients.

Methods: A 5-year retrospective observational study on the clinical presentation and surgical management of perforated peptic ulcer is carried out in a tertiary hospital in Mogadishu, Somalia, Department of General Surgery, from January 2017 to December 2021. Read More

Surg Endosc 2022 May 13. Epub 2022 May 13.

Department of Surgery, Sinai Grace Hospital, Detroit Medical Center, Detroit, MI, USA.

Introduction: Minimally invasive or open Graham Patch repair remains the gold standard approach for management of perforated peptic ulcers (PPU). Herein, we report outcomes of laparoscopic technique and compare it with open approach at a community hospital.

Methods: Retrospective observational study conducted comparing laparoscopic modified Cellan-Jones repair (mCJR) versus the standard open repair of PPU. Read More

Clin Case Rep 2022 Apr 27;10(4):e05780. Epub 2022 Apr 27.

Department of Pathology and Laboratory Medicine Guilan University of Medical Science Rasht Iran.

Appendiceal diverticulitis is an infrequent disease that can mimic other diseases' symptoms or cause different symptoms because of its various complications. However, one of the most frequent complications of this disease is a perforation that can lead to other serious problems such as peritonitis. This complication can threaten a patient's health condition. Read More

J Microbiol Immunol Infect 2022 Mar 29. Epub 2022 Mar 29.

Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Department of Microbiology and Immunology, School of Medicine, China Medical University, Taichung, Taiwan. Electronic address:

Background: The risk of invasive Candida infection (ICI) is high in patients with perforated peptic ulcer (PPU) who received laparotomy or laparoscopic surgery, but the risk factors and predictors of morbidity outcomes remain uncertain. This study aims to identify the risk factors of ICI in surgical critically ill PPU patients and to evaluate the impact on patient's outcomes.

Methods: This is a single-center, retrospective study, with a total of 170 surgical critically ill PPU patients. Read More

Khirurgiia (Mosk) 2022 (4):27-33

Ivanovo State Medical Academy, Moscow, Russia.

Objective: Morphological substantiation of laparoscopic suturing of gastric ulcer with formation of a covered perforation.

Material And Methods: To analyze morphological tissue reaction in surgical area, we used 12 Chinchilla rabbits. All animals were divided into 2 groups by 6 animals. Read More

Br J Surg 2022 Jun;109(7):603-609

Background: Perforated peptic ulcer (PPU) remains a common condition globally with significant morbidity and mortality. Previous work has demonstrated variation in reporting of patient characteristics in PPU studies, making comparison of studies and outcomes difficult. The aim of this study was to standardize the reporting of patient characteristics, by creating a core descriptor set (CDS) of important descriptors that should be consistently reported in PPU research. Read More

Cureus 2022 Feb 27;14(2):e22667. Epub 2022 Feb 27.

Surgery, Hamad Medical Corporation, Doha, QAT.

Introduction: In the emergency room, acute pain in the abdomen is one of the most common symptoms that patients present with, and it is a result of a myriad of causes, leading to an exhaustive differential diagnosis. A perforated peptic ulcer is a rare cause of acute right iliac fossa or lower quadrant abdominal pain. It causes leakage of gastrointestinal contents in the area, resulting in localized inflammation and pain that is clinically similar to acute appendicitis. Read More

J Trauma Acute Care Surg 2022 Jul 1;93(1):e12-e16. Epub 2022 Apr 1.

From the Division of Trauma, Surgical Critical Care and Acute Care Surgery, Department of Surgery, West Virginia University, Morgantown, West Virginia.

Background: Peptic ulcer disease (PUD), once primary a surgical problem, is now medically managed in the majority of patients. The surgical treatment of PUD is now strictly reserved for life-threatening complications. Free perforation, refractory bleeding and gastric outlet obstruction, although rare in the age of medical management of PUD, are several of the indications for surgical intervention. Read More

Am Surg 2022 Mar 25:31348211067991. Epub 2022 Mar 25.

General surgery department, 7714Russells Hall Hospital, Dudley, UK.

Aims: To evaluate comparative outcomes of laparoscopic repair of perforated peptic ulcer with omental patch versus without omental patch.

Methods: A systematic search of multiple electronic data sources was conducted, and all studies comparing laparoscopic repair of perforated peptic ulcer (PPU) with and without omental patch were included. Operative time, postoperative complications, re-operation and mortality were the evaluated outcome parameters for the meta-analysis. Read More

J Gen Fam Med 2022 Mar 2;23(2):126-127. Epub 2021 Nov 2.

Primary Care and Advanced Triage Section Osaka City General Hospital Osaka Japan.

This study sought to describe the case of an 86-year-old man who presented to our hospital complaining of abdominal pain, abdominal distention, and loss of appetite for 4 days prior. This case suggests that an amount of accumulated air clearly highlights the intestinal wall, like a "double-wall sign," even when the patient is standing. Read More

Cureus 2022 Feb 1;14(2):e21800. Epub 2022 Feb 1.

Internal Medicine, MedStar Washington Hospital Center, Washington, USA.

Some patients with schizophrenia and psychotic illnesses have reduced pain perception, and others have decreased pain expression. The diagnosis of the acute abdomen can be delayed, and its outcomes can be worse in psychiatric patients than in non-psychiatric patients. We present a case of perforated peptic ulcer (PPU) in a schizophrenic woman and discuss how the phenomenon of pain insensitivity and diagnostic overshadowing-a process in which a person with mental illness receives inadequate treatment due to a misattribution of physical symptoms to their mental illness-nearly contributed to a missed diagnosis. Read More

Obes Surg 2022 04 1;32(4):1403-1404. Epub 2022 Mar 1.

Atrium Health Weight Management, Section of Bariatric & Metabolic Surgery, Department of Surgery, Carolinas Medical Center, Atrium Health, 2630 East 7th Street, Charlotte, NC, 28204, USA.

Background: Marginal ulcer (MU) and gastro-gastric fistula (GGF) are well-described complications following Roux-en-Y gastric bypass (RYGB). The incidence of MU ranges from 0.6 to 25% and the incidence of GGF following divided RYGB has been reported as high as 6%. Read More

Ethiop J Health Sci 2021 Sep;31(5):975-984

Departtment of Statistics and Research, Ekiti State University Teaching Hospital, Ado-Ekiti, Ekiti State, Nigeria.

Background: Perforated peptic ulcer is a life-threatening complication with a high morbidity and mortality. It is the most common indication for emergency operation in peptic ulcer disease (PUD) patients. This study aimed to describe the pattern of presentation, management and early outcome in patients with perforated PUD. Read More

Ethiop J Health Sci 2021 Sep;31(5):969-974

Department of Surgery, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

Background: Helicobacter Pylori is the most common cause of peptic ulcer disease with disputable association with perorated Peptic Ulcer disease (PPD). This study aims to determine magnitude of Helicobacter Pylori in PPD and the outcomes of treatment, at Saint Paul Hospital Millennium Medical College (SPHMMC).

Method: Between January 9, 2013 and February 7, 2018, all patients operated for PPD were recruited retrospectively. Read More

AME Case Rep 2022 25;6. Epub 2022 Jan 25.

Department of Medicine, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI, USA.

is amongst the most common chronic bacterial infection in humans. Pediatric patients appear to differ from their adult counterparts in terms of the prevalence, the complication rate, and the rate of antibiotic resistance. In this report, we present an 18-year-old man without any past medical history who was evaluated after an episode of syncope. Read More

Gastrointest Endosc 2022 Jul 3;96(1):28-35.e1. Epub 2022 Feb 3.

Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.

Background And Aims: The aim of this study was to evaluate the safety and effectiveness of Hemospray (Cook Medical, Winston-Salem, NC, USA), a hemostatic powder, as monotherapy for active peptic ulcer bleeding.

Methods: In this prospective, multicenter, single-arm study, patients with Forrest Ia or Ib peptic ulcers underwent endoscopic application of Hemospray as treatment of first intent. Effectiveness endpoints were successful hemostasis at the end of the index endoscopy, recurrent bleeding within 72 hours and from 72 hours to 30 days, adverse events requiring reintervention or resulting in morbidity or mortality, and 30-day mortality. Read More

Biomed Res Int 2022 24;2022:9246785. Epub 2022 Jan 24.

The Regional Center for Mycology and Biotechnology, Al-Azhar University, 11787 Nasr City, Cairo, Egypt.

Objective: The present study was aimed at investigating the possible antiulcer activities of some natural phytochemicals leaf extract (APLE) and flower extract (APFE) in addition to the date palm seed extract (DPSE) and the oily samples of DPSE in a pylorus ligation-induced ulcer model using ranitidine as a standard antiulcer drug.

Background: Peptic ulcer is a prevalent gastrointestinal disorder due to hypersecretion of gastric acid. It affects four million people worldwide, and 2-10% of these ulcers are perforated and cause bleeding. Read More

Langenbecks Arch Surg 2022 Jan 28. Epub 2022 Jan 28.

Department of Surgery, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: Perforated peptic ulcer (PPU) is a life-threatening complication of peptic ulcer disease. This condition is characterized by a dirty abdomen that predisposes to postoperative wound infection. Delayed primary skin closure is occasionally preferred over primary closure to reduce the risk of surgical site infection in dirty abdominal wounds. Read More

Clin Nutr ESPEN 2022 02 1;47:299-305. Epub 2021 Dec 1.

Department of Gastrointestinal- and Hepatic Diseases, Surgical Section, Copenhagen University Hospital, Herlev, Borgmester Ib Juuls Vej 1, 2730 Herlev, Denmark.

Background & Aims: Perforation is a severe complication of peptic ulcer disease. Evidence regarding perioperative management of patients undergoing surgery for perforated peptic ulcer is scarce without any clear guidelines. This study aimed to investigate the clinical practice and possible differences in the perioperative management of patients undergoing emergency surgery for perforated peptic ulcers in Denmark. Read More