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Pain Physician 2021 May;24(3):E349-E356

Department of Spinal Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Background: In clinical practice, we have found that the pain caused by thoracolumbar osteoporotic vertebral compression fracture (OVCF) is sometimes not limited to the level of the fractured vertebrae but instead occurs in areas far away from the injured vertebrae, such as the lower back, area surrounding the iliac crest, or buttocks, and this type of pain is known as distant lumbosacral pain. The pathogenesis of pain in distant regions caused by thoracolumbar OVCF remains unclear.

Objectives: To compare the clinical efficacy and imaging outcomes of percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) in the treatment of distant lumbosacral pain accompanied by thoracolumbar OVCF and to explore the possible pathogenesis of distant lumbosacral pain caused by thoracolumbar OVCF. Read More

Pain Physician 2021 May;24(3):E335-E340

Department of Orthopedics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Background: In the aging population, osteoporosis and related complications have become a global public health problem. Osteoporotic vertebral compression fractures are among the most common type of osteoporotic fractures and patients are at risk of secondary vertebral compression fracture.

Objectives: To identify risk factors for secondary vertebral compression fracture following primary osteoporotic vertebral compression fractures. Read More

Sci Rep 2021 May 13;11(1):10184. Epub 2021 May 13.

Department of Orthopedic Surgery, Spine Section, Chang Gung Memorial Hospital, No. 5, Fusing St., Guishan Dist., Taoyuan, 33305, Taiwan.

In some cases of vertebroplasty for adjacent fractures, we observed a cement bridging phenomenon, in which the injected cement flowed from the newly fractured vertebra to the previously cement-augmented vertebra through the space between the abutting anterior longitudinal ligament and the vertebral column. The purpose of this retrospective study was to investigate this phenomenon. From January 2012 to December 2014, patients who sustained new-onset adjacent vertebral compression fracture and who were again treated with vertebroplasty were enrolled. Read More

J Orthop Surg Res 2021 May 13;16(1):312. Epub 2021 May 13.

Department of Spine Surgery, Zibo Central Hospital, Zibo, No. 54 Gongqingtuan Road, Zhangdian District, Zibo City, Shandong Province, Zibo, 255036, Shandong, China.

Objective: The purpose of this research is to evaluate the risk factors and incidence of pulmonary cement embolism (PCE) during percutaneous vertebroplasty (PVP) or kyphoplasty (PKP) for osteoporotic vertebral compression fractures (OVCFs) based on postoperative computed tomography (CT).

Methods: A total of 2344 patients who underwent PVP or PKP due to OVCFs in our spine center were analyzed retrospectively. According to the detection of postoperative pulmonary CT, the patients were divided into two groups: pulmonary cement embolism group (PCE group) and non-pulmonary cement embolism group (NPCE group). Read More

World J Clin Cases 2021 Apr;9(12):2778-2790

Department of Spine Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.

Background: As one of the most common complications of osteoporosis, osteoporotic vertebral compression fracture (OVCF) increases the risk of disability and mortality in elderly patients. Percutaneous vertebroplasty (PVP) is considered to be an effective, safe, and minimally invasive treatment for OVCFs. The recollapse of cemented vertebrae is one of the serious complications of PVP. Read More

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2021 Apr;43(2):153-158

Department of Orthopedics,The Affiliated Jiangning Hospital of Nanjing Medical University,Nanjing 211100,China.

Objective To investigate the effect of sarcopenia on the efficacy of percutaneous kyphoplasty(PKP)in the treatment of osteoporotic spinal compression fracture(OSCF)in elderly patients. Methods From February 2017 to June 2018,a total of 77 elderly patients who met the inclusion and exclusion criteria were included in this study.Grip strength of dominant hand was measured by an electronic grip dynamometer with cut-off values of 27 kg for males and 16 kg for females. Read More

Eur Radiol 2021 May 7. Epub 2021 May 7.

Department of Radiology, Virgen de las Nieves University Hospital, Fuerzas Armadas Av. 2, 18014, Granada, Spain.

Objectives: To assess the current evidence regarding the efficacy of percutaneous vertebroplasty (PVP) over conservative treatment (CT) and placebo in osteoporotic vertebral fractures (OVFs) by performing a meta-analysis of randomized controlled trials (RCTs).

Materials And Methods: A systematic search was conducted on PubMed, EMBASE, and Cochrane databases. The main outcomes were pain relief, improvement of functional disability, and quality of life at different time points: short-term (1-2 weeks), medium-term (1-3 months), and long-term (≥ 6 months). Read More

Spine (Phila Pa 1976) 2021 May 6. Epub 2021 May 6.

Department of Interventional Pain Management, Providence Cedars-Sinai Tarzana Medical Center, Los Angeles, CA, USA Department of Interventional Pain Management, Providence St. Joseph Health Southern California, Mission Hills, CA, USA University of California San Diego School of Medicine, San Diego, CA, USA Department of Physical Medicine and Rehabilitation, University of Utah School of Medicine, Salt Lake City, UT, USA. Spine Fracture Institute, Edmond, OK, USA Director of Neuro-Spine Surgery, Providence Cedars Sinai Tarzana Medical Center, Los Angeles, CA, USA Department of Physical and Rehabilitation Medicine, Turku University Hospital and University of Turku, Turku, Finland.

Study Design: Systematic review and meta-analysis.

Objective: To compare the magnitude and duration of pain relief with vertebral augmentation to any other therapy for the treatment of cancer-related vertebral compression fractures through meta-analysis of randomized controlled trials.

Summary Of Background Data: Derived from search on PubMed, EMBASE, CINAHL, Scopus, Central, Scopus and Web of Science databases in May 2020. Read More

Neurosurg Focus 2021 May;50(5):E11

1Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center; and.

Objective: High-grade metastatic epidural spinal cord compression from radioresistant tumor histologies is often treated with separation surgery and adjuvant stereotactic body radiation therapy. Historically, long-segment fixation is performed during separation surgery with posterior transpedicular fixation of a minimum of 2 spinal levels superior and inferior to the decompression. Previous experience with minimal access surgery techniques and percutaneous stabilization have highlighted reduced morbidity as an advantage to the use of shorter fixation constructs. Read More

J Neurosurg Spine 2021 Apr 30:1-10. Epub 2021 Apr 30.

Departments of1Neurosurgery and.

Objective: Percutaneous vertebroplasty (PV) and balloon kyphoplasty (BK) are two minimally invasive techniques used to treat mechanical pain secondary to spinal compression fractures. A concern for both procedures is the radiation exposure incurred by both operators and patients. The authors conducted a systematic review of the available literature to examine differences in interventionalist radiation exposure between PV and BK and differences in patient radiation exposure between PV and BK. Read More

Ann Thorac Surg 2021 Apr 27. Epub 2021 Apr 27.

(1)Division of Cardiac Surgery, Royal Victoria Hospital, McGill University Health Centre, McGill University, Faculty of Medicine, Montreal, Quebec, Canada. Electronic address:

Intracardiac cement embolism (ICE) after percutaneous vertebroplasty is a rare, but dangerous complication, and guiding principles for its management are not well described. The management of this present case of ICE offers insight to facilitate the treatment decision making process in symptomatic patients requiring extraction. Read More

Biomed Res Int 2021 8;2021:6650358. Epub 2021 Apr 8.

Department of Orthopaedics, China-Japan Friendship Hospital, Beijing 100029, China.

Objective: We conducted this meta-analysis to provide better evidence of the efficacy and safety of zoledronic acid (ZA) combined with percutaneous vertebroplasty/kyphoplasty (PVP/PKP) on osteoporotic vertebral compression fracture (OVCF) and proposed a protocol for its application in clinical practice.

Methods: All randomized controlled trials (RCTs) of ZA combined with PVP or PKP compared to individual PVP/PKP for the management of patients with OVCFs were included in this study. Electronic database searches were conducted from database inception to November 2020, including the Cochrane Library, PubMed, Web of Science, and Embase. Read More

Int J Spine Surg 2021 Apr 1;15(2):353-358. Epub 2021 Apr 1.

Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Background: Percutaneous balloon kyphoplasty (BK) is widely accepted as both a safe and effective method for the treatment of symptomatic benign vertebral compression fractures (VCFs) of the thoracic and lumbar spines. A disruption in the posterior wall of the affected vertebra is often considered to be a relative or an absolute contraindication to BK. This study was performed to determine the safety as well as the efficacy of BK for vertebral body compression fractures associated with posterior wall disruption. Read More

Medicine (Baltimore) 2021 Apr;100(16):e25396

Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, Henan Province Intelligent Orthopedic Technology Innovation and Transformation International Joint Laboratory, Henan Key Laboratory for Intelligent Precision Orthopedics, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Henan Zhengzhou.

Abstract: To identify the risk factors of the secondary fractures for osteoporotic vertebral compression fractures (OVCFs) after percutaneous vertebroplasty (PVP).We conducted a search of relevant articles using Cochrane Library, PubMed, Medline, Science Direct, Embase, the Web of Science and other databases. The time range we retrieved from establishment of the electronic database to November 2017. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Apr;35(4):471-476

Department of Orthopedics, SSL Central Hospital of Dongguan City, Affiliated Shilong People's Hospital of Southern Medical University, Dongguan Guangdong, 523326, P.R.China.

Objective: To investigate the feasibility and mechanical properties of polymethyl methacrylate (PMMA) bone cement and allogeneic bone mixture to strengthen sheep vertebrae with osteoporotic compression fracture.

Methods: A total of 75 lumbar vertebrae (L -L ) of adult goats was harvested to prepare the osteoporotic vertebral body model by decalcification. The volume of vertebral body and the weight and bone density before and after decalcification were measured. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Apr;35(4):464-470

Department of Orthopedics, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan Shandong, 250001, P.R.China.

Objective: To report an improved classification system of Kümmell's disease and its clinical application.

Methods: Based on CT and MRI, an improved classification system of Kümmell's disease was proposed in terms of the integrity of sagittal endplate, the integrity of posterior wall of vertebral body, and the degree of vertebral compression. Between January 2011 and March 2018, the improved classification system was used to evaluate and guide the treatment of 78 patients with Kümmell's disease. Read More

Radiol Med 2021 Apr 12. Epub 2021 Apr 12.

SC Neuroradiologia, ASST Carlo Poma, Str. Lago Paiolo, 10, 46100, Mantova, MN, Italy.

Purpose: To demonstrate the utility of a biopsy performed just before vertebroplasty in patients with diagnosis of vertebral compression fracture (VCF) and no history of neoplastic or hematologic diseases.

Background: Osteoporosis is the most frequent cause of vertebral compression fracture, with trauma and pathologic vertebral weakening being other common causes. Since secondary fractures at imaging investigation can present as simple compression fractures, it is important to identify an underlying pathology. Read More

Radiologia 2021 Apr 2. Epub 2021 Apr 2.

Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España.

Interventional radiology is playing an increasingly important role in the local treatment of bone metastases; this treatment is usually done with palliative intent, although in selected patients it can be done with curative intent. Two main groups of techniques are available. The first group, centered on bone consolidation, includes osteoplasty / vertebroplasty, in which polymethyl methacrylate (PMMA) is injected to reinforce the bone and relieve pain, and percutaneous osteosynthesis, in which fractures with nondisplaced or minimally bone fragments are fixed in place with screws. Read More

Semin Ultrasound CT MR 2021 Apr 29;42(2):164-183. Epub 2020 Aug 29.

Department of Musculoskeletal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.

The mechanisms by which tumors metastasize to bone are complex. Upon the successful establishment of metastatic deposits in the skeleton, detection of the disease becomes essential for therapeutic planning. The roles of CT, skeletal scintigraphy, SPECT/CT, MRI, PET/CT and PET/MRI will be reviewed. Read More

J Int Med Res 2021 Mar;49(3):3000605211001720

Department of Hepatobiliary, Pancreatic, and Splenic Surgery, 117872Hebei General Hospital, Shijiazhuang, China.

We present a case of an 81-year-old man with gallbladder gangrene after percutaneous vertebroplasty (PV) that was successfully treated via laparoscopic cholecystectomy (LC). The patient underwent multilevel, thoracic PV for painful osteoporotic compression fractures. PV performed at the T6 level was complicated by severe abdominal pain owing to direct embolization of the right T6 segmental artery with penetration of bone cement into the radicular artery beneath the pedicle. Read More

Case Rep Oncol 2021 Jan-Apr;14(1):279-283. Epub 2021 Mar 2.

Department of Oncology, University Hospitals of Geneva, Geneva, Switzerland.

Bone is a frequent site of metastases in advanced cancers including lung, breast, prostate, kidney, or myeloma. Lesions are commonly located on the spine. Neoplastic invasion of the vertebral body can result in painful vertebral fractures, leading to disability and substantial morbidity. Read More

J Coll Physicians Surg Pak 2021 Mar;31(3):330-333

Department of Orthopaedics, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, China.

Osteoporotic vertebral compression fracture (OVCF) is a common disease among the elderly individuals. With the aging of the population development, the incidence of OVCF is increasing. Cementation of vertebral body like percutaneous vertebroplasty (PVP) is a minimally invasive and effective treatment. Read More

J Neurointerv Surg 2021 Mar 23. Epub 2021 Mar 23.

Neurosurgery, Ente Ecclesiastico Ospedale Generale Regionale Francesco Miulli, Acquaviva delle Fonti, Italy.

Background: Both surgery and conservative management are well established treatments for compression fractures of the thoraco-lumbar spine without neurological compromise. This article aims to compare the outcomes of conservative management to those of vertebroplasty, a relatively safe and simple procedure.

Methods: 102 patients were admitted to our neurosurgical unit between January 2012 and February 2016, presenting with a single-level, post-traumatic A1 or A2 Mager l type fracture, affecting the thoracic-lumbar spine without any neurological deficits. Read More

World Neurosurg 2021 Mar 13. Epub 2021 Mar 13.

Department of Orthopedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Objective: We sought to evaluate the efficacy and complications of percutaneous vertebroplasty with different viscosities and volumes of bone cement in treating osteoporotic vertebral compression fractures (OVCFs).

Method: We conducted a retrospective cohort study of 307 patients treated for a single thoracolumbar level (T12-L2) OVCF in our hospital between January 2014 and December 2019. The patients were divided into 6 groups according to different viscosities (I: low-viscosity bone cement, II: high-viscosity bone cement) and injection volumes (A, 2-4 mL; B, 4-6 mL; C, 6-8 mL) of bone cement. Read More

Geriatr Orthop Surg Rehabil 2021 23;12:2151459321996178. Epub 2021 Feb 23.

Department of Orthopedics, Clinical Medical College of Yangzhou University, Yangzhou, China.

Introduction: To analyze perioperative hidden blood loss (HBL) and its influencing factors in elderly patients with osteoporotic vertebral compression fracture (OVCF) treated with percutaneous vertebroplasty (PVP).

Materials And Methods: From January 2016 to December 2018, 103 elderly patients with OVCF (age > 85 years) treated with PVP were selected. The patient's height, weight, duration of symptoms, previous medical history and other basic information were recorded. Read More

Global Spine J 2021 Mar 11:2192568221999369. Epub 2021 Mar 11.

Department of Orthopedic Surgery, 159407The First Hospital of China Medical University, Shenyang, People's Republic of China.

Study Design: Meta-analysis.

Objective: To systematically compare the effectiveness and safety of vertebral augmentation procedure (VAP) with non-surgical management (NSM) for the treatment of osteoporotic vertebrate compression fractures (OVCFs).

Methods: Systematic reviews and meta-analyses with the comparison between VAP and NSM were identified to extract randomized controlled trials from electronic database. Read More

J Orthop Surg Res 2021 Mar 10;16(1):183. Epub 2021 Mar 10.

Department of Orthopedics, Ninth Hospital of Xi'An, Xi'An, 710000, ShaanXi, China.

Purpose: To investigate risk factors of bone cement leakage in percutaneous vertebroplasty(PVP)for osteoporotic vertebral compression fracture (OVCF).

Methods: A total of 236 patients (344 vertebrae) who underwent PVP between November 2016 and June 2020 were enrolled in the study. Clinical and radiological characteristics, including age, gender, course of disease, trauma, type of vertebral fracture, cortical continuity of vertebral body, intervertebral vacuum cleft (IVC), fracture severity, fracture level, basivertebral foramen, bone cement dispersion types, the cement injection volume, the type of cement leakage, puncture approach, and intrusion of the posterior wall, were considered as potential risk factors. Read More

Zhongguo Gu Shang 2021 Jan;34(1):26-33

Songjiang District Central Hospital, Shanghai 201600, China.

Objective: To establish a three-dimensional finite element model of osteoporosis and to study the stiffness recovery of injured vertebrae and stress analysis of adjacent vertebrae after percutaneous vertebroplasty under different perfusion and distribution conditions by simulating fluid flow into the vertebral body.

Methods: A male healthy volunteer was selected. CT scans were performed from T to L. Read More

Am J Case Rep 2021 Mar 4;22:e928055. Epub 2021 Mar 4.

Division of Community Medicine, Kanazawa Medical University Himi Municipal Hospital, Himi, Toyama, Japan.

BACKGROUND The etiology of syndrome of inappropriate antidiuretic hormone secretion (SIADH) is highly variable. With little evidence, much of the guidance and recommendations available for management are based on clinical judgement. Although percutaneous balloon kyphoplasty can effectively relieve the severe pain associated with osteoporotic vertebral compression fractures that do not respond to conventional treatments, the effect of balloon kyphoplasty on SIADH associated with vertebral compression fracture remains unknown. Read More

Acta Ortop Mex 2020 Sep-Oct;34(5):293-297

Neurosurgery Department. Hospital Regional de Alta Especialidad del Bajío, Universidad de Guanajuato. León, Gto., México.

Introduction: Multiple myeloma represents 1% of all cancers and 10% of hematological cancers. Up to 80-90% of cases will have skeletal involvement and the spine is the most frequently involved site. Any intervention must be aimed to improve the patients functional prognosis and will impact their quality of life. Read More