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    1 OF 94

    Differences in UGT1A1 gene mutations and pathological liver changes between Chinese patients with Gilbert syndrome and Crigler-Najjar syndrome type II.
    Medicine (Baltimore) 2017 Nov;96(45):e8620
    Department of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
    Diagnosis of Crigler-Najjar syndrome type II (CNS-II) and Gilbert syndrome (GS) based on the serum bilirubin concentration is difficult, because this parameter can fluctuate under certain conditions. The aim of this study was to explore differences in UGT1A1 gene mutations, which cause both CNS and GS, and pathological changes between CNS-II and GS.Ninety-five Chinese patients with hereditary unconjugated hyperbilirubinemia were enrolled in this study. Read More

    A case report of mixed acinar-endocrine carcinoma of the pancreas treated with S-1 chemotherapy: Does it work or induce endocrine differentiation?
    Medicine (Baltimore) 2017 Nov;96(45):e8534
    aDepartment of Gastroenterology and Hepatology, Kobe City Medical Center West Hospital bDepartment of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
    Rationale: Acinar cell carcinomas (ACCs) and mixed acinar-endocrine carcinomas (MAECs) of the pancreas are rare, accounting for only 1% of pancreatic tumors. Although both typically present at an advanced stage, chemotherapeutic regimes have not yet been standardized.

    Patient Concerns: A 65-year-old man presented with a large mass in the pancreatic tail with multiple liver metastases. Read More

    A Fatal Case of Intra-Abdominal Hemorrhage Following Diagnostic Blind Percutaneous Liver Biopsy in a Patient With Peliosis Hepatis.
    Gastroenterology Res 2017 Oct 26;10(5):318-321. Epub 2017 Oct 26.
    Department of General Surgery, Westchester University Medical Center, Valhalla, NY, USA.
    Peliosis hepatis (PH) is a rare vascular condition of the liver characterized by the presence of cystic blood filled cavities distributed randomly throughout the liver parenchyma. We describe a case of a 42-year-old previously healthy male patient, airlifted to us in a state of hemorrhagic shock after undergoing percutaneous diagnostic liver biopsy for lesions seen on CT scan. Repeat CT scan with IV contrast on presentation in our hospital showed intraperitoneal bleeding. Read More

    An isolated metachronous metastasis to the adrenal gland from a pancreatic neuroendocrine tumor: A case report.
    Int J Surg Case Rep 2017 Oct 19;41:169-173. Epub 2017 Oct 19.
    Department of Surgery, Jichi Medical University, Tochigi, Japan. Electronic address:
    Introduction: Pancreatic neuroendocrine tumors are rare. Treatment includes aggressive local management of the primary lesion and metastases, and systemic somatostatin. This is the first report of an isolated metachronous metastasis to the adrenal gland from a pancreatic neuroendocrine tumor that presented 90 months after the primary tumor. Read More

    Long-term follow-up of complete remission of advanced hepatocellular carcinoma following sorafenib therapy: A case report.
    Oncol Lett 2017 Oct 22;14(4):4853-4856. Epub 2017 Aug 22.
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 41940, Republic of Korea.
    Sorafenib is a tyrosine kinase inhibitor that has been demonstrated to improve the overall survival time of patients with advanced hepatocellular carcinoma (HCC). Although there have been a number of reports of patients achieving complete remission (CR) following sorafenib therapy, the long-term clinical outcomes of these patients have yet to be ascertained. A 72-year-old male patient with chronic hepatitis C, diabetes, hypertension and an old cerebral infarction was referred for the evaluation of a liver mass identified on an abdominal ultrasound. Read More

    Comparison of the Diagnostic Yield of EUS Needles for Liver Biopsy: Ex Vivo Study.
    Diagn Ther Endosc 2017 13;2017:1497831. Epub 2017 Sep 13.
    University of Maryland, Baltimore, MD, USA.
    Background And Aims: EUS-guided liver biopsy is an emerging method of liver tissue acquisition which is safe and had been shown to produce excellent histological yield. There is limited data comparing the diagnostic yield of different FNA needles. We aimed to compare the diagnostic performance of four commercially available 19-gauge FNA needles. Read More

    Percutaneous microwave ablation liver partition and portal vein embolization for planned hepatectomy due to large gastrointestinal stromal tumor metastases: A case report.
    Medicine (Baltimore) 2017 Oct;96(42):e8271
    aDepartment of Hepatopancreatobiliary Surgery and Minimally Invasive Surgery bDepartment of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.
    Rationale: The liver is the most frequent site of relapse of gastrointestinal stromal tumors (GISTs). Surgery is always considered to be unsuitable because of the multiple metastases.

    Patient Concerns: In this report, we describe a case of large, multiple GIST liver metastases that were treated with percutaneous microwave ablation liver partition and portal vein embolization for planned hepatectomy (PALPP). Read More

    Kras mutation is a marker of worse oncologic outcomes after percutaneous radiofrequency ablation of colorectal liver metastases.
    Oncotarget 2017 Sep 2;8(39):66117-66127. Epub 2017 Aug 2.
    Section of Interventional Radiology, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
    Background: Kras mutation has been associated with shorter overall survival and time to disease recurrence after resection of colorectal liver metastases (CLM). This study evaluated the prognostic value of Kras mutation in patients with CLM treated by percutaneous radiofrequency ablation (RFA).

    Methods: This is an IRB waived retrospective analysis of the impact of KRAS mutation status on oncologic outcomes after CLM RFA. Read More

    Percutaneous US-guided Cholecystocholangiography with Microbubbles for Assessment of Infants with US Findings Equivocal for Biliary Atresia and Gallbladder Longer than 1.5 cm: A Pilot Study.
    Radiology 2017 Oct 4:170173. Epub 2017 Oct 4.
    From the Department of Medical Ultrasonics, Institute for Diagnostic and Interventional Ultrasound (L.Y.Z., S.L.C., Y.H., X.Y.X.), Department of Pediatric Surgery (H.D.C.), and Department of Anesthesiology (Y.X.Q.), the First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Rd 2, Guangzhou 510080, P.R. China; and Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou, P.R. China (W.Z.).
    Purpose To evaluate the feasibility of ultrasonographically (US) guided percutaneous cholecystocholangiography (PCC) for early exclusion of biliary atresia (BA) in infants suspected of having BA with equivocal US findings or indeterminate type of BA and a gallbladder longer than 1.5 cm at US. Materials and Methods This study was approved by the ethics committee; written informed parental consent was obtained. Read More

    Adequacy of percutaneous non-targeted liver biopsy under real-time ultrasound guidance when comparing the Biopince™ and Achieve™ biopsy needle.
    Br J Radiol 2017 Dec 3;90(1080):20170397. Epub 2017 Oct 3.
    1 Department of Radiology, Royal Derby Hospital , Derby , UK.
    Objective: The purpose of this study was to compare the adequacy rates of percutaneous liver biopsies, in parenchymal liver disease, using the Biopince(TM) (Argon Medical, Texas, TX, ) 16G and Achieve(TM) (Carefusion, Illinois, IL, USA) 18G biopsy needles in relation to the Royal College of Pathologists guidelines and to assess risk of complications.

    Methods: Data for all percutaneous non-targeted "medical" liver biopsies using the Biopince 16G and Achieve 18G biopsy needles were collected retrospectively over a 2-year period. Total biopsy core length and number of portal tracts was recorded along with adequacy of biopsy as assessed according to Royal College of Pathologists criteria. Read More

    Percutaneous liver biopsy and revised coagulation guidelines: a 9-year experience.
    Abdom Radiol (NY) 2017 Sep 19. Epub 2017 Sep 19.
    Department of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI, 53792, USA.
    Purpose: To retrospectively review revised pre-procedural coagulation guidelines for percutaneous liver biopsy to determine whether their implementation is associated with increased hemorrhagic complications on a departmental scale. Secondary endpoints were to determine the effect of this change on pre-procedural blood product (FFP and platelet) utilization, to evaluate the impact of administered blood products on hemorrhagic complications, and to determine whether bleeding complications were related to INR and platelet levels.

    Materials And Methods: This IRB-approved, HIPAA-compliant, retrospective study reviewed 1846 percutaneous liver biopsies in 1740 patients, comparing biopsies performed, while SIR consensus pre-procedural coagulation guidelines were in place (INR ≤ 1. Read More

    Effects of Dapagliflozin on Body Composition and Liver Tests in Patients with Nonalcoholic Steatohepatitis Associated with Type 2 Diabetes Mellitus: A Prospective, Open-label, Uncontrolled Study.
    Curr Ther Res Clin Exp 2017 8;87:13-19. Epub 2017 Jul 8.
    Department of Gastroenterology and Hepatology, Shimane University Faculty of Medicine, Izumo, Japan.
    Background: Nonalcoholic steatohepatitis (NASH) is an active form of nonalcoholic fatty liver disease. Risk factors for NASH include type 2 diabetes mellitus (T2DM) and obesity. Sodium-glucose cotransporter 2 (SGLT2) inhibitors used to treat T2DM prevent glucose reabsorption in the kidney and increase glucose urinary excretion. Read More

    A case of perirenal extramedullary hematopoiesis in a patient with primary myelofibrosis.
    CEN Case Rep 2017 Nov 11;6(2):194-199. Epub 2017 Sep 11.
    Department of Nephrology, Japanese Red Cross Nagoya Daiichi Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya, Aichi, Japan.
    Extramedullary hematopoiesis (EMH) is hematopoiesis in organs outside the bone marrow and most frequently occurs in the liver, spleen, and lymph nodes. We report a case of perirenal EMH revealed by kidney biopsy in a patient with primary myelofibrosis. We observed only bilateral kidney enlargement with plain computed tomography (CT) and ultrasonography before obtaining a renal biopsy. Read More

    Percutaneous lung ablation of pulmonary recurrence may improve survival in selected patients undergoing cytoreductive surgery for colorectal cancer with peritoneal carcinomatosis.
    Eur J Surg Oncol 2017 Oct 31;43(10):1939-1948. Epub 2017 Aug 31.
    University of New South Wales, Department of Surgery, St George Hospital, Kogarah, Australia. Electronic address:
    Purpose: To analyze the outcomes of patients developing pulmonary metastases (PM) following cytoreductive surgery (CRS) and perioperative intra-peritoneal chemotherapy (IPC) for colorectal cancer (CRC) with peritoneal carcinomatosis.

    Patients And Methods: A retrospective analysis of patients undergoing CRS/IPC for CRC from 1996 to 2016 was performed. Lung-specific disease-free and patient overall survival was analyzed. Read More

    Diagnostic value of FIB-4, aspartate aminotransferase-to-platelet ratio index and liver stiffness measurement in hepatitis B virus-infected patients with persistently normal alanine aminotransferase.
    World J Gastroenterol 2017 Aug;23(31):5746-5754
    Department of Hepatology, the Third Hospital of Zhenjiang Affiliated Jiangsu University, Zhenjiang 212001, Jiangsu Province, China.
    Aim: To assess the diagnostic value of FIB-4, aspartate aminotransferase-to-platelet ratio index (APRI), and liver stiffness measurement (LSM) in patients with hepatitis B virus infection who have persistently normal alanine transaminase (PNALT).

    Methods: We enrolled 245 patients with chronic hepatitis B: 95 in PNALT group, 86 in intermittently elevated alanine transaminase (PIALT1) group [alanine transaminase (ALT) within 1-2 × upper limit of normal value (ULN)], and 64 in PIALT2 group (ALT > 2 × ULN). All the patients received a percutaneous liver biopsy guided by ultrasonography. Read More

    Enhanced liver fibrosis test as a reliable tool for assessing fibrosis in nonalcoholic fatty liver disease in a clinical setting.
    Int J Biol Markers 2017 Oct 31;32(4):e397-e402. Epub 2017 Oct 31.
    Department of Internal Medicine and Gastroenterology, Gemelli University Hospital, Catholic University of Sacred Heart, Rome - Italy.
    Background: Liver fibrosis is the main determinant and predictor of the clinical course of nonalcoholic fatty liver disease (NAFLD). To date, a liver biopsy is still considered the gold standard for staging fibrosis. The aim of this study was to investigate the diagnostic accuracy of the commercial enhanced liver fibrosis (ELF) test manufacturer's cutoff value (≥9. Read More

    Microwave Ablation (MWA): Basics, Technique and Results in Primary and Metastatic Liver Neoplasms - Review Article.
    Rofo 2017 Nov 23;189(11):1055-1066. Epub 2017 Aug 23.
    Institute for Diagnostic and Interventional Radiology, Frankfurt University Hospital, Frankfurt am Main, Germany.
    Purpose The locoregional interventional oncological treatment approach is an accepted modality for liver neoplasms, especially for hepatocellular carcinoma (HCC) and oligonodular liver metastases. Materials and Methods The main aim of ablation therapies like microwave ablation (MWA) is to eradicate all malignant cells in a minimally invasive technique under imaging guidance while preserving the healthy tissue with a sufficient safety margin (at least 5 mm) surrounding the ablated lesion. Results Ablation therapy can be performed via a percutaneous, laparoscopic or intraoperative approach under ultrasound, MRI or CT guidance for adequate localization and monitoring of the ablation process. Read More

    Long Half-life (89)Zr Labeled Radiotracers Can Guide In Suite Percutaneous Molecular Imaging PET/CT-guided Biopsies Without Reinjection of Radiotracer.
    J Nucl Med 2017 Aug 17. Epub 2017 Aug 17.
    MSKCC, United States.
    Rationale: To evaluate the feasibility of in suite Zr89 labeled radiotracer positron emission tomography-computed tomography (PET/CT)-guided biopsies performed without reinjection. Methods: From 2013-2016, 12 patients (7 males, 5 females; mean age 61 years, range 40-75) with suspected metastatic prostate or breast carcinoma on either imaging or biochemical progression underwent 14 percutaneous biopsies after diagnostic PET/CT using (89)Zr labeled radiotracers (mean dose: 180MBq; range: 126-189MBq) targeting prostate specific membrane antigen (PSMA) (n = 7) or human epidermal growth factor receptor 2 (HER2) (n = 5). Biopsies were performed in a PET/CT suite without radiotracer reinjection. Read More

    Validation of the Simplified Criteria for the Diagnosis of Autoimmune Hepatitis in Chilean-Hispanic Patients.
    Ann Hepatol 2017 Sep-Oct;16(5):772-779
    Department of Gastroenterology. Faculty of Medicine. Pontificia Universidad Católica de Chile.
    Introduction And Aim: In 2008 the International autoimmune hepatitis (AIH) Group proposed the simplified diagnostic criteria for this disease. The original cohort study was performed in 11 international centers, but validation studies are scarce in Latin-America. The aim of this study is validate these criteria in Hispanic patients. Read More

    Clinical Characteristics and Complications of Pediatric Liver Biopsy: A Single Centre Experience.
    Ann Hepatol 2017 Sep-Oct;16(5):797-801
    Hepatology and Nutrition, BC Children's Hospital Division of Pediatric Gastroenterology.
    Introduction: Percutaneous liver biopsy (LB) is the gold standard method for evaluation and management of patients with liver disease. The purpose of this study was to characterize pediatric patients undergoing LB at British Columbia Children's Hospital, and to determine the rate and timing of complications following the procedure.

    Material And Methods: The medical records of all pediatric patients who underwent LB during a six-year retrospective study were reviewed to collect demographic and procedure-related data. Read More

    A Prototype Educational Model for Hepatobiliary Interventions: Unveiling the Role of Graphic Designers in Medical 3D Printing.
    J Digit Imaging 2017 Aug 14. Epub 2017 Aug 14.
    Department of Radiology, George Washington University Hospital, 900 23rd St. NW, Suite G2092, Washington, DC, 20037, USA.
    In the context of medical three-dimensional (3D) printing, in addition to 3D reconstruction from cross-sectional imaging, graphic design plays a role in developing and/or enhancing 3D-printed models. A custom prototype modular 3D model of the liver was graphically designed depicting segmental anatomy of the parenchyma containing color-coded hepatic vasculature and biliary tree. Subsequently, 3D printing was performed using transparent resin for the surface of the liver and polyamide material to develop hollow internal structures that allow for passage of catheters and wires. Read More

    Ablative safety margin depicted by fusion imaging with post-treatment contrast-enhanced ultrasound and pre-treatment CECT/CEMRI after radiofrequency ablation for liver cancers.
    Br J Radiol 2017 Oct 27;90(1078):20170063. Epub 2017 Jul 27.
    1 Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Shanghai, China.
    Objective: To evaluate the value of fusion imaging with post-treatment contrast-enhanced ultrasound (CEUS) and pre-treatment contrast-enhanced CT/MRI (CECT/CEMRI) in evaluating ablative safety margin after percutaneous ultrasound (US)-guided radiofrequency ablation (RFA) for liver cancers.

    Methods: 34 consecutive patients with 47 liver lesions who had undergone RFA were included. Fusion imaging with post-treatment CEUS and pre-treatment CECT/CEMRI was carried out to evaluate local treatment response and ablative safety margin within 1-3 days after RFA. Read More

    [Bone metastases of a gallbladder carcinoma detected by positron emission tomography/computed tomography: Case report].
    Rev Med Chil 2017 Apr;145(4):527-532
    Medicina Nuclear, Clínica Santa María, Santiago, Chile.
    Signet ring gallbladder carcinoma is a rare aggressive variant of mucinous adenocarcinoma with poor prognosis. Positron emission tomography/computed tomography (PET/CT) with Fluor18 deoxyglucose (F18-FDG) is a useful tool in the staging of gallbladder cancer. We report a 68 years old man with a surgically resected acute cholecystitis, whose biopsy was positive for signet ring cell gallbladder carcinoma. Read More

    MR-guided Percutaneous Biopsy of Focal Hepatic Dome Lesions with Free-hand Combined with MR Fluoroscopy Using 1.0-T Open High-field Scanner.
    Anticancer Res 2017 08;37(8):4635-4641
    Department of Interventional MRI, Shandong Medical Imaging Research Institute, Shandong University, Jinan, P.R. China
    Aim: To prospectively estimate the safety, feasibility and accuracy of 1.0T open-magnetic resonance (MR)-guided percutaneous biopsy in free-hand of focal lesions located in the hepatic dome.

    Materials And Methods: All percutaneous MR-guided biopsies of the lesions were performed at the Shandong Medical Imaging Research Institute. Read More

    A case of multiple inflammatory hepatic pseudotumor protruding from the liver surface after colonic cancer.
    Int J Surg Case Rep 2017 8;37:261-264. Epub 2017 Jun 8.
    Division of Surgery Gastroenterological Center, Medico Shunju Shiroyama Hospital, Osaka, Japan; Division of Surgery Osaka Medical college, Osaka, Japan; Division of Pathology Osaka Medical college, Osaka, Japan.
    Introduction: Inflammatory hepatic pseudotumor (IHPT) is an important benign liver disease because it is difficult to clinically and radiologically distinguish from malignant tumors.

    Presentation Of Case: Here, we describe a case of a 67-year-old male patient diagnosed with multiple inflammatory hepatic pseudotumors. The patient had undergone left hemicolectomy for descending colonic cancer (T3 N0 M0 stage IIA) 2 years prior. Read More

    Venobiliary fistula with haemobilia: a rare complication of percutaneous liver biopsy.
    BMJ Case Rep 2017 Jul 14;2017. Epub 2017 Jul 14.
    Gastroenterology, New York University Langone Medical Center/Bellevue Hospital Center, New York , New York, USA.
    We describe a case of a 36-year-old man with a history of chronic hepatitis C who presented with abdominal pain 3 days after undergoing a percutaneous ultrasound-guided liver biopsy. Initial investigations revealed a venobiliary fistula with haemobilia and obstructive jaundice with direct bilirubin peaking at 9.2 mg/dL. Read More

    Interventional radiology in breast cancer.
    Breast 2017 Oct 10;35:98-103. Epub 2017 Jul 10.
    Interventional Radiology, King's College London, London, UK; Guy's and St Thomas's Hospital, London, UK. Electronic address:
    Molecular profiling of metastatic disease may greatly influence the systemic therapy recommended by oncologists and chosen by patients, allowing treatment to be more targeted. Comprehensive care of patients with advanced breast cancer now includes percutaneous image-guided biopsy if this has the potential to influence systemic treatment [1]. Interventional radiologists can contribute significantly to the care of patients affected by breast cancer, in diagnostic and supportive procedures and importantly also in treatment. Read More

    Ramipril-associated cholestasis in the setting of recurrent drug-induced liver injury.
    Gastroenterol Hepatol Bed Bench 2017 ;10(2):143-146
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
    Aim: Angiotensin-converting enzyme inhibitors (ACEIs) are commonly used to treat hypertension. Although generally well tolerated, the adverse effects of ACEIs include hypotension, cough, acute kidney injury and hyperkalemia. Rare reports of ACEI-induced hepatotoxicity have been described, most notably a cholestatic pattern of injury related to captopril. Read More

    Role of Hepatobiliary Scintigraphy and Preoperative Liver Biopsy for Exclusion of Biliary Atresia in Neonatal Cholestasis Syndrome.
    Indian J Pediatr 2017 Sep 8;84(9):685-690. Epub 2017 Jul 8.
    Department of Pediatric Surgical Superspecialties, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh, 226014, India.
    All diagnostic algorithms for Neonatal Cholestasis Syndrome (NCS) focus on differentiating numerous medical causes from Biliary Atresia (BA). No preoperative diagnostic algorithm has 100% diagnostic accuracy for BA and yet, timely diagnosis is crucial to optimize surgical outcome. Markers for high index of clinical suspicion for BA are: a "usually" well thriving infant with conjugated hyperbilirubinemia, raised gamma glutamyl transpeptidase, persistently "acholic" stools, firm hepatomegaly with dysmorphic, hypoplastic gall bladder. Read More

    Intrahepatic cholangiocarcinoma producing granulocyte colony-stimulating factor and parathyroid hormone-related protein.
    Nihon Shokakibyo Gakkai Zasshi 2017 ;114(7):1285-1292
    Department of Gastroenterology, Teikyo University Mizonoguchi Hospital.
    A 78-year-old man was referred to our hospital with suspected liver abscess. Fever and inflammatory reaction resolved after percutaneous drainage and administration of antibiotics. However, leukocyte count was remarkably increased, and hypercalcemia was noted. Read More

    The management of colorectal liver metastases.
    Clin Radiol 2017 Aug 24;72(8):617-625. Epub 2017 Jun 24.
    Department of Interventional Radiology, University Hospital Southampton, Tremona Rd, Southampton SO16 6YD, UK. Electronic address:
    Colorectal cancer remains a leading cause of cancer-related death in Europe. Approximately one-quarter of patients have synchronous hepatic metastases and metachronous liver metastases occur in a further 30%. The scope of surgery in management of colorectal metastases has evolved to include selected patients with extra-hepatic disease for whom R0 resection is considered feasible; however, locoregional treatments are increasingly recognised as viable management options in those patients deemed unsuitable for surgery and there is an expanding body of evidence regarding their ability to achieve local control and increase progression-free survival in the liver. Read More

    Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma with aggressive biological behavior (adverse clinical course): A case report.
    Pathol Res Pract 2017 Oct 10;213(10):1322-1326. Epub 2017 Jun 10.
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address:
    Combined primary hepatic neuroendocrine carcinoma (PHNEC) and hepatocellular carcinoma (HCC) is a very rare malignant hepatic tumor. Its prognosis and histological features are uncertain. Here we report the case of such a tumor in a 70-year-old male Japanese patient with adverse prognosis. Read More

    Outpatient Liver Biopsy in Children: Safety, Feasibility, and Economic Impact.
    J Pediatr Gastroenterol Nutr 2017 Jul;65(1):86-88
    Department of Gastroenterology and Clinical Nutrition, The Royal Children's Hospital, Melbourne, Australia.
    Liver biopsy is a valuable tool. Even though outpatient liver biopsies are routinely performed in adults, there are no clear recommendations on its safety and feasibility in children. We reviewed the records of children who underwent a percutaneous liver biopsy at our institution between January 2005 and June 2015. Read More

    Georgian Med News 2017 May(266):34-39
    Department of Interventional Radiology, Tbilisi State Medical University, "High Technology Medical Center - University Clinic", Ltd, Georgia.
    Case report presents the successful treatment of solitary liver metastasis in a patient with resected colon cancer. A 39-year-old male underwent left hemicolectomy with colostomy formation followed by chemotherapy for a moderately differentiated adenocarcinoma of the colon. Two years later, a liver metastatic lesion was detected. Read More

    Liver metastases from gastric carcinoma: A Case report and review of the literature.
    Curr Probl Cancer 2017 May - Jun;41(3):222-230. Epub 2017 Mar 24.
    Department of Surgical Oncology, Medical University of Lublin, Lublin, Poland. Electronic address:
    Gastric carcinoma (GC) is the fifth most common malignancy worldwide but the third leading cause of cancer death, and surgery remains the only curative treatment option. Prognosis of patients with liver metastases from gastric carcinoma (LMGC) is poor, and the optimal treatment of metastatic gastric cancer remains a matter of debate. In 2002, a 53-year-old male patient with GC and synchronous oligometastatic lesion in liver VIII segment underwent a total gastrectomy combined with metastasectomy. Read More

    Long-term survival after multidisciplinary therapy for residual gallbladder cancer with peritoneal dissemination: a case report.
    Surg Case Rep 2017 Dec 14;3(1):76. Epub 2017 Jun 14.
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
    Background: Although surgical resection is the only curative treatment for gallbladder cancer (GBC), concomitant peritoneal dissemination is considered far beyond the scope of resection. We report a long-term survivor with a residual GBC with multiple peritoneal disseminations who underwent an extended resection after effective chemotherapy.

    Case Presentation: A 59-year-old male underwent an open cholecystectomy for Mirizzi syndrome at a local hospital. Read More

    Limited Post-observation Period in Pediatric Outpatient Ultrasound-Guided Liver Biopsies.
    Cardiovasc Intervent Radiol 2017 Dec 8;40(12):1899-1903. Epub 2017 Jun 8.
    Texas Children's Hospital, 6701 Fannin St, Ste 470, Houston, TX, 77030-2608, USA.
    Purpose: We retrospectively studied whether a limited 2 h post-biopsy observation period after a percutaneous outpatient ultrasound-guided liver biopsy is a sufficient monitoring period for children.

    Materials And Methods: This study is an IRB-approved retrospective cohort review of consecutive outpatient percutaneous ultrasound-guided liver biopsies from June 01, 2014, to June 30, 2016. A total of 198 biopsies in 192 patients (85 females and 113 males) underwent an outpatient ultrasound-guided liver biopsy between June 01, 2014, and June 30, 2016 (age range 3 weeks-18 years, mean 11. Read More

    A Case of Rheumatoid Vasculitis Involving Hepatic Artery in Early Rheumatoid Arthritis.
    J Korean Med Sci 2017 Jul;32(7):1207-1210
    Division of Rheumatology, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
    Rheumatoid vasculitis is a rare, but most serious extra-articular complications of long-standing, seropositive rheumatoid arthritis (RA). Vasculitis of hepatic artery is an extremely rare but severe manifestation of rheumatoid vasculitis. A 72-year-old woman who presented with polyarthralgia for 2 months was diagnosed with early RA. Read More

    Percutaneous Cholecystostomy and Hydrodissection in Radiofrequency Ablation of Liver Subcapsular Leiomyosarcoma Metastasis Adjacent to the Gallbladder: Protective Effect.
    J Radiol Case Rep 2016 Oct 31;10(10):24-32. Epub 2016 Oct 31.
    Department of Interventional Radiology, Hospital Israelita Albert Einstein, São Paulo, Brazil.
    Uterine leiomyosarcoma is an uncommon pathology, predominantly found in aged population. Patients with metastatic disease have poor survival and therapy mainly consists of palliative systemic chemotherapy. However, more aggressive strategies such as radiofrequency ablation (RFA) may benefit patients with limited secondary disease. Read More

    Liver Safety of Statins in Prediabetes or T2DM and Nonalcoholic Steatohepatitis: Post Hoc Analysis of a Randomized Trial.
    J Clin Endocrinol Metab 2017 Aug;102(8):2950-2961
    Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, Florida 32610.
    Context: Patients with nonalcoholic fatty liver disease have a high cardiovascular risk, but statins are rarely prescribed because of fear of hepatotoxicity.

    Objective: To prospectively assess the long-term safety of statins in patients with prediabetes/type 2 diabetes mellitus (T2DM) and nonalcoholic steatohepatitis (NASH).

    Design: Post hoc analysis of statin use during a randomized, controlled trial assessing pioglitazone vs placebo for NASH. Read More

    Use of microwave ablation in the treatment of patients with multiple primary malignant tumors.
    Thorac Cancer 2017 Jul 31;8(4):365-371. Epub 2017 May 31.
    Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    A 56-year-old man was admitted to our hospital in 2007, complaining of an irritating cough. Computed tomography examination demonstrated a mass in the right lung and enlargement of the hilar and mediastinal lymph nodes. Small cell lung cancer was confirmed by pathological examination after fibro-bronchoscope biopsy. Read More

    A noninvasive diagnosis of hepatic fibrosis by BioFibroScore® in chronic hepatitis C patients.
    J Gastroenterol Hepatol 2017 May 26. Epub 2017 May 26.
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
    Background & Aims: The diagnostic accuracy of a novel serological panel (BioFibroScore®) to predict hepatic fibrosis in patients with chronic hepatitis C virus (HCV) infection is unknown.

    Methods: Three markers of BioFibroScore®, including urokinase plasminogen activator (uPA), matrix metalloproteinase-9 (MMP-9), and beta-2 microglobulin (β2M), were retrospectively evaluated in 635 HCV-infected patients who received percutaneous liver biopsy and FibroScan®. The formula of BioFibroScore® to predict the severity of hepatic fibrosis was developed by Adaboost algorithm. Read More

    Establishment of patient-derived tumor xenograft (PDTX) models using samples from CT-guided percutaneous biopsy.
    Braz J Med Biol Res 2017 May 18;50(6):e6000. Epub 2017 May 18.
    Nanjing Personal Oncology Biological Technology Co. Ltd., Nanjing, Jiangsu, China.
    This study aimed to investigate the feasibility of the establishment of a human cancer xenograft model using samples from computed tomography (CT)-guided percutaneous biopsy. Fresh tumor tissues obtained from 10 cancer patients by CT-guided percutaneous biopsy were subcutaneously inoculated into NOD-Prkdcem26Il2rgem26Nju (NCG) mice to establish human patient-derived tumor xenograft (PDTX) models. The formation of first and second generation xenografts was observed, and tumor volume was recorded over time. Read More

    Real-time elastography (RTE): a valuable sonography-based non-invasive method for the assessment of liver fibrosis in chronic hepatitis B.
    Abdom Radiol (NY) 2017 Nov;42(11):2632-2638
    Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
    Purpose: To investigate the diagnostic usefulness of real-time elastography (RTE) for liver fibrosis in chronic hepatitis B (CHB).

    Methods: 89 CHB patients were enrolled in the cross-sectional study. Ultrasound-guided percutaneous liver biopsies, RTE, and blood testing were performed in all patients. Read More

    Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline - Updated January 2017.
    Endoscopy 2017 Jul 16;49(7):695-714. Epub 2017 May 16.
    Department of Gastroenterology and Hepatology, Medical Centre for Postgraduate Education and Department of Gastroenterology, M. Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland.
    For pancreatic solid lesions, ESGE recommends performing endoscopic ultrasound (EUS)-guided sampling as first-line procedure when a pathological diagnosis is required. Alternatively, percutaneous sampling may be considered in metastatic disease.Strong recommendation, moderate quality evidence. Read More

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