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Mol Ther 2019 Mar 20. Epub 2019 Mar 20.

Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China. Electronic address:

By fusing the extracellular domain of the natural killer (NK) cell receptor NKG2D to DAP12, we constructed a chimeric antigen receptor (CAR) to improve NK cell tumor responses. An RNA electroporation approach that provides transient expression of the CAR was adopted as a risk mitigation strategy. Expression of the NKG2D RNA CAR significantly augmented the cytolytic activity of NK cells against several solid tumor cell lines in vitro and provided a clear therapeutic benefit to mice with established solid tumors. Read More

Crit Care Nurse 2019 Apr;39(2):15-28

Bridget K. Dittman is a clinical nurse practice leader in the intensive care unit at Einstein Center Montgomery in East Norriton, Pennsylvania.

Introduction: Only a few cases of biventricular cardiogenic shock have been treated with Impella circulatory assist devices in the United States.

Clinical Findings: A 29-year-old man came to the emergency department because of cough, shortness of breath, fever, and chills. Initial assessment revealed hypotension; an elevated creatinine level of 2. Read More

J Cardiol 2019 Mar 27. Epub 2019 Mar 27.

Adolescent and Adult Congenital Program, Children's Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

The Fontan procedure has led to increased long-term survival of patients with single ventricle congenital heart disease. Hemodynamic changes associated with the Fontan circulation, including elevated central venous pressure and diminished cardiac output are responsible for the development of Fontan-associated liver disease (FALD). Liver fibrosis is a universal feature following the Fontan operation. Read More

Case Rep Gastrointest Med 2019 17;2019:3087541. Epub 2019 Feb 17.

Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, USA.

A 57-year-old gentleman with a past medical history of well-differentiated pancreatic neuroendocrine tumor (NET) with liver metastases was transferred to our hospital with abdominal pain. He underwent percutaneous liver biopsy three days prior to admission as a part of a study protocol for treatment of his progressive NET. He developed gastrointestinal bleeding and was found to have a distended gallbladder filled with high density material on ultrasound. Read More

Cancer Imaging 2019 Mar 18;19(1):15. Epub 2019 Mar 18.

Department of Interventional Radiology, Peking University Cancer Hospital & Institute, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), 52 Fucheng Road, Haidian District, Beijing, 100142, China.

Background: The technique for arterial infusion chemotherapy (HAIC) is not standardized which limits its widely application. The aim of this study was to evaluate the long-term functionality and complications of port-catheter system using percutaneous unilateral trans-femoral implantation with coil only fixed-catheter-tip method.

Methods: From January 2013 to January 2017, 205 consecutive patients (138 men; aged 28-88 years; mean, 59. Read More

Med Mal Infect 2019 Mar 11. Epub 2019 Mar 11.

Service de maladies infectieuses, université de Sfax, CHU Hédi Chaker, Tunisia.

Objectives: Several non-invasive markers have recently been proposed to predict liver fibrosis without percutaneous liver biopsy (PLB). We aimed to evaluate the performance of non-invasive scores and to highlight the value of a new combined score in the prediction of liver fibrosis in chronic hepatitis B (CHB) patients.

Patients And Methods: We performed a retrospective study of patients presenting with CHB who underwent PLB between 2008 and 2016. Read More

Ann Hepatobiliary Pancreat Surg 2019 Feb 28;23(1):8-12. Epub 2019 Feb 28.

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Backgrounds/aims: Focal nodular hyperplasia (FNH) is one of the most common benign tumors of the liver. There is still a lack of evidence on surgical indications for FNH. This study intended to analyze the surgical indications for FNH. Read More

Dig Liver Dis 2019 Feb 12. Epub 2019 Feb 12.

Division of Gastroenterology & Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; Vienna Hepatic Hemodynamic Laboratory, Medical University of Vienna, Vienna, Austria. Electronic address:

Background: Transjugular liver biopsy (TJLB) represents an alternative to percutaneous liver biopsy especially in patients with impaired coagulation and ascites.

Aims: To describe safety and diagnostic yield of aspiration TJLB performed by hepatologists experienced in hepatic venous pressure gradient (HVPG) measurements.

Methods: 445 TJLB of 399 patients between 01/2007-12/2016 were retrospectively assessed. Read More

Gastrointest Endosc Clin N Am 2019 Apr 2;29(2):173-186. Epub 2019 Feb 2.

Department of Gastroenterology and Nutrition, Geisinger Medical Center, 100 North Academy Avenue, 21-11, Danville, PA 17822, USA. Electronic address:

There remains an important role for liver biopsy in the management of liver disorders. Image-guided liver biopsy can be obtained with percutaneous or transjugular approaches. Real-time image-guided liver biopsy can be accomplished with endoscopic ultrasound (EUS). Read More

Aliment Pharmacol Ther 2019 Apr 3;49(7):840-863. Epub 2019 Mar 3.

Liver Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Background: Budd-Chiari syndrome (BCS) is a rare but fatal disease caused by obstruction in the hepatic venous outflow tract.

Aim: To provide an update of the pathophysiology, aetiology, diagnosis, management and follow-up of BCS.

Methods: Analysis of recent literature by using Medline, PubMed and EMBASE databases. Read More

Clin Infect Dis 2019 Feb 28. Epub 2019 Feb 28.

School of Medicine, China Medical University, Taichung, Taiwan.

Background: Data on noninvasive liver fibrosis staging after viral eradication is unclear. This histology-based study validated the performance of liver stiffness (LS) measurement after viral eradication.

Methods: Consecutive participants with chronic hepatitis C (CHC) who received concomitant LS measurement through acoustic radiation force impulse (ARFI) elastography and percutaneous liver biopsy were prospectively screened and analyzed. Read More

BMC Surg 2019 Feb 18;19(1):23. Epub 2019 Feb 18.

Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Kita15-Nishi7, Kita-Ku, Sapporo, Hokkaido, 060-8638, Japan.

Background: Percutaneous transhepatic portal embolization (PTPE) is useful for safe major hepatectomy. This study investigated the correlation between hepatic hypertrophy and hemodynamics of portal venous flow by ultrasound sonography after PTPE.

Methods: We analyzed 58 patients with PTPE, excluding those who underwent recanalization (n = 10). Read More

Autops Case Rep 2018 Oct-Dec;8(4):e2018048. Epub 2018 Oct 9.

University of Campinas (Unicamp), School of Medical Sciences, Department of Gastroenterology (Gastrocentro). Campinas, SP, Brazil.

The differential diagnosis of hepatic focal lesions is challenging because the etiology can be inflammatory, infectious, and even neoplastic. A rare cause of metastatic liver nodules is cardiac angiosarcoma. We report a case of this tumor, which was diagnosed only after autopsy. Read More

Dig Liver Dis 2019 Jan 22. Epub 2019 Jan 22.

Division of Gastroenterology, Oregon Health & Science University, Portland, OR, United States. Electronic address:

Background: Liver biopsy through endoscopic ultrasound (EUS) has become a novel approach for tissue acquisition. We aim to evaluate the adequacy of EUS-guided liver biopsies in comparison to those obtained through interventional radiology (IR) techniques.

Methods: A retrospective single-center analysis was performed of all IR (transjugular or image-guided percutaneous) and EUS-guided liver biopsies performed at an academic medical center from January 2016 to January 2018. Read More

Saudi J Gastroenterol 2019 Mar-Apr;25(2):81-88

The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University; Liver Diseases Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.

Background/aim: For resectable extrahepatic cholangiocarcinoma with biliary obstruction, it remains a controversy whether to choose percutaneous transhepatic biliary drainage (PTBD) or endoscopic biliary drainage (EBD). A systematic review was conducted to compare the long-term efficacy between the two techniques.

Materials And Methods: Eligible studies were searched from January 1990 to May 2018, comparing the long-term efficacy between EBD and PTBD for extrahepatic cholangiocarcinoma. Read More

Interact Cardiovasc Thorac Surg 2019 Jan 28. Epub 2019 Jan 28.

Department of Cardiovascular Surgery, Sana-Herzzentrum Cottbus, Cottbus, Germany.

Objectives: Although percutaneous edge-to-edge mitral valve repair with the MitraClip system is becoming widely adopted in clinical practice, surgical experience on how to correct failed MitraClip therapy is limited. We aimed to analyse the surgical and pathological outcomes after surgical revision of the failed MitraClip therapy.

Methods: Between January 2011 and January 2018, 25 patients (age 73 ± 9 years; men 48%; New York Heart Association class 3. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):1979-1981

Dept. of Gastroenterological Surgery, Osaka Police Hospital.

A 50's woman referred to our hospital with high serum CEA level was found to have RAS-wild sigmoid colon cancer with a 15 cm size unresectable synchronous liver metastasis(LM)in the right lobe during the endoscopic, radiological, and immunohistological examinations. CapeOX was introduced, but the LM lesion enlarged to 18 cm after 2 courses. Therefore, the regimen was switched to FOLFIRI plus panitumumab. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):1949-1951

Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences.

Peritoneal metastasis is relatively rare in patients with hepatocellular carcinoma(HCC). No consensus has been reached regarding the treatment of this type of metastasis. Herein, we report 3 patients who underwent resection of peritoneal metastasis due to HCC. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2183-2185

Dept. of Surgery, Tsushimi Hospital.

A 76-year-old woman with lower bile duct carcinoma underwent subtotal stomach-preserving pancreaticoduodenectomy (SSPPD)after percutaneous transhepatic biliary drainages(PTBD). Nine months after the operation, chest computed tomography revealed a mass in the subcutis of the right chest wall, which was a different lesion from that in the PTBD site. The aspiration biopsy cytology and needle biopsy indicated no malignant findings. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2180-2182

Dept. of Surgery, Matsusaka Central General Hospital.

A 49-year-old woman received a detailed examination for a myoma uteri, and a hepatic tumor was detected incidentally. A CT scan showed a tumor 6 cm in diameter in the posterior segment, which was irregularly enhanced. The tumor showed a low signal intensity on T1WI MRI and a slightly high intensity with high-density spots on T2WI. Read More

Zhonghua Gan Zang Bing Za Zhi 2019 Jan;27(1):56-58

Diagnosis Center of Infectious Diseases, the First Affiliated Hospital, Zhejiang University, Hangzhou 310000, China.

J Pediatr Gastroenterol Nutr 2019 Apr;68(4):e71

Lucile Packard Children's Hospital, Stanford, CA.

J Pediatr Gastroenterol Nutr 2019 Apr;68(4):e71

Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Oncol Lett 2019 Jan 5;17(1):823-830. Epub 2018 Nov 5.

Department of Surgery, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.

The present study reports a case of mass-forming intrahepatic cholangiocarcinoma (ICC), which mimicked cholangiocellular carcinoma (CoCC) during imaging and a needle biopsy examination. A 51-year-old female with no relevant medical history was referred to the National Defense Medical College hospital with an intrahepatic tumor. Computed tomography demonstrated non-homogeneous enhancement in the early arterial phase and persistent enhancement in the portal and equilibrium phases, together with notable swelling of the para-aortic lymph nodes. Read More

J Am Anim Hosp Assoc 2019 Mar/Apr;55(2):e55203. Epub 2019 Jan 17.

From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, Ohio (E.T.H., V.J.P.); and Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina (J.M.C.).

A 9 mo old female intact golden retriever presented for evaluation of chronic lethargy and decreased appetite. The serum biochemistry profile revealed increased liver enzymes consistent with a mixed hepatocellular and cholestatic pattern. A multiphase computed tomography angiography was performed to evaluate for a portosystemic shunt. Read More

Diagn Interv Radiol 2019 Jan;25(1):71-80

Motion Research, Ancaster, ON, Canada.

Purpose: Percutaneous tissue biopsy is a mainstay of diagnostic and interventional radiology, providing a minimally invasive method for diagnosing malignant and benign disease. The purpose of this review was to collect and summarize the best available evidence regarding the risk factors associated with bleeding complications in image-guided liver biopsy.

Methods: A literature review was performed, searching Medline, EMBASE, CINAHL, the Cochrane Library, the National Institute for Health and Care Excellence (NICE) and Canadian Agency for Drugs and Technology in Health (CADTH) databases for any studies evaluating bleeding complications in image-guided liver biopsy. Read More

Eur Radiol 2019 Jan 14. Epub 2019 Jan 14.

Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Purpose: The aim of this study is to identify the micro-mechanical characteristics that define biopsy performance in normal ex vivo animal organs.

Materials And Methods: Three biopsy systems with differences of needle external diameter, tray height and effective tray length were assessed. Sampling was performed in porcine liver and kidneys with commercially labelled 14G, 16G and 18G, using 2-cm throw needle systems. Read More

Case Reports Hepatol 2018 9;2018:5305691. Epub 2018 Dec 9.

Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka 814-0180, Japan.

Patients with autoimmune hepatitis (AIH) may sometimes have concomitant idiopathic thrombocytopenic purpura (ITP). Severe thrombocytopenia in ITP interferes with percutaneous liver biopsy for pathological diagnosis of AIH. Here, we report a case of AIH with ITP in a 63-year-old woman. Read More

Am J Transplant 2019 May 4;19(5):1545-1551. Epub 2019 Feb 4.

Department of Surgery, University of California San Francisco, San Francisco, California.

Although liver biopsy is the gold standard for assessing allograft health, its attendant risk has deterred its use in routine monitoring of stable liver transplant recipients during long-term follow-up. We utilized prospectively collected data on adverse events from 2 clinical trials of immunosuppression withdrawal to quantify the risk of liver biopsy in pediatric liver transplant recipients. The trials included 451 liver biopsies in 179 children. Read More

Ultrasound Int Open 2019 Jan 23;5(1):E11-E19. Epub 2018 Nov 23.

Ultrasound Section, Division of Surgery, Dep of Gastroenterology, Herlev Hospital, Copenhagen Academy for Medical Education and Simulation University of Copenhagen, Denmark.

US-guided percutaneous biopsy of focal liver lesions (FLL) is a classic interventional procedure performed by almost all radiology units. Typically, an incidental focal finding on US or a focal indeterminate lesion diagnosed on CT, MRI or PET/CT is referred for US-guided biopsy for final diagnosis. The introduction of microbubble US contrast agents has overcome some of the limitations of standard US in diagnosing FLLs by displaying the microvasculature together with the US morphology, which has increased both the sensitivity and the specificity. Read More

J Cancer Res Ther 2018 ;14(7):1650-1654

Department of Neurosurgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.

Purpose: The objective of the study is to explore the etiology, clinical manifestations, imaging features, diagnosis, treatment, and prognosis of cerebral air embolism complicated computed tomography (CT) scan-guided percutaneous liver biopsy.

Materials And Methods: A case of air embolism was developed in the brain during a CT-guided percutaneous needle biopsy of the liver. In addition, retrospective analysis was performed on the previously reported typical cases of cerebral air embolism secondary to CT-guided percutaneous lung biopsy. Read More

J Gastrointestin Liver Dis 2018 Dec;27(4):399-407

Regional Institute of Gastroenterology and Hepatology;3rd Surgical Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Aims: To report on the long-term impact of tumor and non-tumor related parameters on local recurrence, distant recurrence and survival in patients with naïve or recurrent type hepatocellular carcinoma (HCC) treated by radiofrequency ablation (RFA).

Methods: We performed 240 RFA sessions on 133 patients with 156 HCC nodules developed on a background of liver cirrhosis and analyzed the outcomes.

Results: Contrast-enhanced ultrasound performed one month after RFA showed complete ablation in 119 out of 133 (89. Read More

Arq Gastroenterol 2018 Jul-Sep;55(3):208-211

Universidade Estadual do Ceará (UECE), Faculdade de Medicina, Fortaleza, CE, Brasil.

Background: Though strongly suggestive of metastasis, focal lesions on liver scans of oncological patients require histological confirmation for the prescription of adequate treatment.

Objective: To evaluate the safety and efficacy of US-guided percutaneous core liver biopsy.

Methods: Descriptive, cross-sectional study based on secondary data from 171 patients submitted to US-guided percutaneous core liver biopsy at the diagnostic radiology service of the Ceará Cancer Institute (ICC, Brazil) between February 2010 and March 2015. Read More

J Cancer Res Ther 2018 Dec;14(Supplement):S1158-S1162

Department of General Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan, China.

Purpose: To investigate the role of percutaneous transhepatic cholangial drainage (PTCD) combined with percutaneous endoscopic jejunostomy (PEJ) in maintaining the nutrition state in patients with advanced ampullary neoplasms.

Materials And Methods: Sixty patients who suffered from advanced ampullary neoplasms and could not tolerate internal drainage operation or biliary stent placement were enrolled. After PTCD, PEJ was implemented, and then the enteral nutrient solution + bile were instilled through PEJ tube for enteral nutrition support. Read More

Pediatr Radiol 2019 03 30;49(3):342-350. Epub 2018 Nov 30.

Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Radiology 3NW47, Philadelphia, PA, 19104, USA.

Background: Patients who have undergone the Fontan operation for palliation of congenital heart disease with single-ventricle pathophysiology are at high risk for developing progressive liver fibrosis. Pathological assessment from percutaneous liver biopsy is central to the management of Fontan-associated liver disease, but liver biopsy in this vulnerable population poses unique challenges and potential risks.

Objective: This retrospective study describes our experience with percutaneous liver biopsy performed to assess changes of Fontan-associated liver disease, with particular regard to procedural outcomes. Read More

J Vasc Interv Radiol 2018 12;29(12):1770-1772

Department of Radiology, Lahey Hospital and Medical Center, 41 Mall Rd., Burlington, MA 01805.

Eur Radiol 2019 May 3;29(5):2426-2435. Epub 2018 Dec 3.

Department of Interventional and Diagnostic Imaging, University Hospital of Caen, Avenue de la Côte de Nacre, 14033, Caen Cedex, France.

Purpose: This study was conducted in order to investigate the safety and accuracy of percutaneous transluminal forceps biopsy (PTFB) during percutaneous biliary drainage (PTBD) in patients with a suspicion of malignant biliary stricture.

Material And Methods: Fifty consecutive patients with obstructive jaundice underwent PTFB during PTBD. Biopsy specimens were obtained using 5. Read More

Cureus 2018 Aug 24;10(8):e3197. Epub 2018 Aug 24.

Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, USA.

Lafora disease is fatal intractable progressive myoclonic epilepsy. It is frequently characterized by epileptic seizures, difficulty walking, muscle spasms, and dementia in late childhood or adolescence. We chronicle here an unusual case of an asymptomatic young male soccer player who presented with elevated liver enzymes. Read More

Mymensingh Med J 2018 Oct;27(4):826-833

Dr Muhammad Shariful Hasan, Medical Officer, Department of Paediatric Gastroenterology & Nutrition, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Biliary atresia is the commonest cause of cholestatic jaundice. Early diagnosis & surgical correction helps long time survival & prevent development of cirrhosis. This study was conducted to find out the role of liver biopsy in the diagnosis of biliary atresia having positive hepatobiliary scintigraphy as there is chance of false positivity. Read More

JGH Open 2018 Oct 1;2(5):242-245. Epub 2018 Oct 1.

Department of Pathology University Malaya Kuala Lumpur Malaysia.

A 33-year-old man was referred with hyperosmotic symptoms of 4 weeks. Clinical examination showed palpable hepatomegaly and no stigmata of liver disease. Findings were random glucose 16. Read More

Onco Targets Ther 2018 26;11:7513-7519. Epub 2018 Oct 26.

Department of Respiratory Medicine, Peking Union Medical College Hospital, Dongcheng District, Beijing 100730, China,

Objective: Acquired T790M mutations account for 50%-60% of tyrosine kinase inhibitor (TKI)-resistant mechanisms in mutation-positive (m+) non-small-cell lung cancer (NSCLC) patients, and re-biopsy is recommended to detect these mutations. We investigated the re-biopsy status and the T790M incidence rate in patients after treatment with icotinib, which is the first-generation EGFR-TKI widely used in China.

Patients And Methods: Target patients had EGFRm+NSCLC, who were progressed after icotinib therapy. Read More

Int J Toxicol 2018 Nov 19:1091581818811306. Epub 2018 Nov 19.

4 Aclairo Pharmaceutical Development Group Inc, Vienna, VA, USA.

Regional therapies for metastatic liver disease have garnered interest in recent years due to technological advances in drug delivery. A percutaneous hepatic perfusion (PHP) using a newly developed generation 2 (GEN2) filtration system was designed to mitigate systemic toxicity and cardiovascular risk associated with hepatic blood filtration during hepatic artery infusion of the chemotherapy drug melphalan. The GEN2 system was evaluated in healthy swine, and plasma samples were assessed for clinical chemistry, melphalan toxicokinetics (TK), inflammatory cytokines, catecholamines, hematological, and cardiac biomarkers. Read More

Ann Med Surg (Lond) 2018 Dec 2;36:99-105. Epub 2018 Nov 2.

Dept. of Paediatric Surgery, PGIMS Rohtak, Haryana, India.

Cystic echinococcosis (CE) is a widely endemic helminthic disease caused by infection with metacestodes (larval stage) of the Echinococcus granulosus tapeworm and transmitted by dogs. are common parasites in certain parts of the world, and are present on every continent with the exception of Antarctica. As a result, a large number of people are affected by CE. Read More

Transplant Proc 2018 Nov 19;50(9):2882-2884. Epub 2018 Mar 19.

Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan.

The effective treatment for hepatocellular carcinoma (HCC) with American Joint Committee on Cancer stage IIIB remains controversial and challenging because of the high recurrence rate after resection and low survival rate. The median survival of those with macroscopic portal vein tumor thrombus (PVTT) is short. We reported such a case which received liver transplantation (LT) after successful consecutive downstaging therapies. Read More

Eur J Radiol 2018 Nov 19;108:133-139. Epub 2018 Sep 19.

Radiology Department, Angers University Hospital, Angers, France; HIFIH Laboratory, UPRES 3859, SFR 4208, Bretagne Loire University, Angers, France.

Objectives: Advanced chronic liver disease is frequent yet largely underdiagnosed. Doppler-US is a common examination and we recently identified three simple Doppler-US signs associated with severe liver fibrosis. Recent Doppler-US devices include elastography modules, allowing for liver stiffness measurement (LSM). Read More

Gastrointest Endosc 2019 02 31;89(2):238-246.e3. Epub 2018 Oct 31.

Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Background And Aims: EUS-guided liver biopsy (LB) is an emerging technique over conventional percutaneous (PC) or transjugular (TJ) approaches. Recent studies have reported that EUS-guided LB may have a better safety profile than PC LB or TJ LB without compromising diagnostic yield, and the outcomes are varied with respect to the types of biopsy needles. We performed a systematic review and meta-analysis to estimate the diagnostic yield, specimen adequacy, and adverse events associated with EUS-guided LB. Read More

J Viral Hepat 2019 Feb 28;26(2):297-307. Epub 2018 Nov 28.

Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, Beijing, China.

The limitations of liver biopsy have led to the development of indirect noninvasive models for liver fibrosis assessment. We aimed to evaluate and compare the performance of 30 noninvasive models to predict fibrosis stage in treatment-naïve and treated chronic hepatitis B (CHB) patients. A total of 576 Chinese treatment-naïve CHB patients and 236 treated CHB patients who had undergone percutaneous liver biopsy were included in the analysis. Read More

Radiol Case Rep 2019 Jan 28;14(1):129-132. Epub 2018 Oct 28.

Department of Diagnostic Imaging, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA.

Hemothorax is a rare complication of percutaneous needle biopsy in the chest at a rate of 0.092%. Rarer yet is diaphragm injury with herniation of intra-abdominal organs. Read More

J Med Case Rep 2018 Oct 27;12(1):314. Epub 2018 Oct 27.

Department of Medical Laboratory, National Hospital Organization Kanazawa Medical Center, 1-1 Shimoishibiki, Kanazawa, 920-8650, Japan.

Background: Most colorectal cancer liver metastases form nodules within the hepatic parenchyma, and hepatectomy is the only radical treatment for synchronous metastases. There is concern about intrabiliary tumor growth which may affect the surgical margin, resulting in local recurrence after hepatectomy for colorectal cancer liver metastasis; however, there has been no report of the dissemination in the bile duct after hepatectomy. Here, we report an unusual case of biliary dissemination of colorectal cancer that caused recurrent intrabiliary growth after hepatectomy, and discuss the management of intrabiliary metastasis of colorectal cancer. Read More

HPB (Oxford) 2018 Oct 23. Epub 2018 Oct 23.

Department of Surgery, Amsterdam UMC, University of Amsterdam, the Netherlands.

Background: Hepatobiliary scintigraphy (HBS) is used to quantify total and regional liver function. Transient elastography (TE) provides a non-invasive alternative to percutaneous biopsy to assess liver fibrosis and cirrhosis. This study aims to determine the correlation between HBS and histopathology of liver parenchyma, and to compare these with TE in patients with resectable hepatocellular carcinoma (HCC). Read More