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Eur J Case Rep Intern Med 2016 18;3(2):000359. Epub 2016 Jan 18.

Department of Internal Medicine, Bnai Zion Medical Center, Haifa, Israel.

Percutaneous liver biopsy (PLB) is a common procedure in patients with liver disease. Bleeding after PLB is rare, with an incidence of 0.35%. Read More

Dig Liver Dis 2019 Jan 22. Epub 2019 Jan 22.

Division of Gastroenterology, Oregon Health & Science University, Portland, OR, United States. Electronic address:

Background: Liver biopsy through endoscopic ultrasound (EUS) has become a novel approach for tissue acquisition. We aim to evaluate the adequacy of EUS-guided liver biopsies in comparison to those obtained through interventional radiology (IR) techniques.

Methods: A retrospective single-center analysis was performed of all IR (transjugular or image-guided percutaneous) and EUS-guided liver biopsies performed at an academic medical center from January 2016 to January 2018. Read More

Interact Cardiovasc Thorac Surg 2019 Jan 28. Epub 2019 Jan 28.

Department of Cardiovascular Surgery, Sana-Herzzentrum Cottbus, Cottbus, Germany.

Objectives: Although percutaneous edge-to-edge mitral valve repair with the MitraClip system is becoming widely adopted in clinical practice, surgical experience on how to correct failed MitraClip therapy is limited. We aimed to analyse the surgical and pathological outcomes after surgical revision of the failed MitraClip therapy.

Methods: Between January 2011 and January 2018, 25 patients (age 73 ± 9 years; men 48%; New York Heart Association class 3. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2180-2182

Dept. of Surgery, Matsusaka Central General Hospital.

A 49-year-old woman received a detailed examination for a myoma uteri, and a hepatic tumor was detected incidentally. A CT scan showed a tumor 6 cm in diameter in the posterior segment, which was irregularly enhanced. The tumor showed a low signal intensity on T1WI MRI and a slightly high intensity with high-density spots on T2WI. Read More

Zhonghua Gan Zang Bing Za Zhi 2019 Jan;27(1):56-58

Diagnosis Center of Infectious Diseases, the First Affiliated Hospital, Zhejiang University, Hangzhou 310000, China.

J Pediatr Gastroenterol Nutr 2019 Jan 21. Epub 2019 Jan 21.

Lucile Packard Children's Hospital, 725 Welch Road, Room 1862, Stanford, CA 94305.

J Pediatr Gastroenterol Nutr 2019 Jan 21. Epub 2019 Jan 21.

Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi - 110070.

Oncol Lett 2019 Jan 5;17(1):823-830. Epub 2018 Nov 5.

Department of Surgery, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.

The present study reports a case of mass-forming intrahepatic cholangiocarcinoma (ICC), which mimicked cholangiocellular carcinoma (CoCC) during imaging and a needle biopsy examination. A 51-year-old female with no relevant medical history was referred to the National Defense Medical College hospital with an intrahepatic tumor. Computed tomography demonstrated non-homogeneous enhancement in the early arterial phase and persistent enhancement in the portal and equilibrium phases, together with notable swelling of the para-aortic lymph nodes. Read More

J Am Anim Hosp Assoc 2019 Jan 17. Epub 2019 Jan 17.

From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, Ohio (E.T.H., V.J.P.); and Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina (J.M.C.).

A 9 mo old female intact golden retriever presented for evaluation of chronic lethargy and decreased appetite. The serum biochemistry profile revealed increased liver enzymes consistent with a mixed hepatocellular and cholestatic pattern. A multiphase computed tomography angiography was performed to evaluate for a portosystemic shunt. Read More

Diagn Interv Radiol 2019 Jan;25(1):71-80

Motion Research, Ancaster, ON, Canada.

Purpose: Percutaneous tissue biopsy is a mainstay of diagnostic and interventional radiology, providing a minimally invasive method for diagnosing malignant and benign disease. The purpose of this review was to collect and summarize the best available evidence regarding the risk factors associated with bleeding complications in image-guided liver biopsy.

Methods: A literature review was performed, searching Medline, EMBASE, CINAHL, the Cochrane Library, the National Institute for Health and Care Excellence (NICE) and Canadian Agency for Drugs and Technology in Health (CADTH) databases for any studies evaluating bleeding complications in image-guided liver biopsy. Read More

Eur Radiol 2019 Jan 14. Epub 2019 Jan 14.

Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Purpose: The aim of this study is to identify the micro-mechanical characteristics that define biopsy performance in normal ex vivo animal organs.

Materials And Methods: Three biopsy systems with differences of needle external diameter, tray height and effective tray length were assessed. Sampling was performed in porcine liver and kidneys with commercially labelled 14G, 16G and 18G, using 2-cm throw needle systems. Read More

Case Reports Hepatol 2018 9;2018:5305691. Epub 2018 Dec 9.

Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka 814-0180, Japan.

Patients with autoimmune hepatitis (AIH) may sometimes have concomitant idiopathic thrombocytopenic purpura (ITP). Severe thrombocytopenia in ITP interferes with percutaneous liver biopsy for pathological diagnosis of AIH. Here, we report a case of AIH with ITP in a 63-year-old woman. Read More

Am J Transplant 2019 Jan 7. Epub 2019 Jan 7.

Department of Surgery, University of California San Francisco, San Francisco, California.

Although liver biopsy is the gold standard for assessing allograft health, its attendant risk has deterred its use in routine monitoring of stable liver transplant recipients during long-term follow-up. We utilized prospectively collected data on adverse events from 2 clinical trials of immunosuppression withdrawal to quantify the risk of liver biopsy in pediatric liver transplant recipients. The trials included 451 liver biopsies in 179 children. Read More

Ultrasound Int Open 2019 Jan 23;5(1):E11-E19. Epub 2018 Nov 23.

Ultrasound Section, Division of Surgery, Dep of Gastroenterology, Herlev Hospital, Copenhagen Academy for Medical Education and Simulation University of Copenhagen, Denmark.

US-guided percutaneous biopsy of focal liver lesions (FLL) is a classic interventional procedure performed by almost all radiology units. Typically, an incidental focal finding on US or a focal indeterminate lesion diagnosed on CT, MRI or PET/CT is referred for US-guided biopsy for final diagnosis. The introduction of microbubble US contrast agents has overcome some of the limitations of standard US in diagnosing FLLs by displaying the microvasculature together with the US morphology, which has increased both the sensitivity and the specificity. Read More

J Cancer Res Ther 2018 ;14(7):1650-1654

Department of Neurosurgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.

Purpose: The objective of the study is to explore the etiology, clinical manifestations, imaging features, diagnosis, treatment, and prognosis of cerebral air embolism complicated computed tomography (CT) scan-guided percutaneous liver biopsy.

Materials And Methods: A case of air embolism was developed in the brain during a CT-guided percutaneous needle biopsy of the liver. In addition, retrospective analysis was performed on the previously reported typical cases of cerebral air embolism secondary to CT-guided percutaneous lung biopsy. Read More

J Gastrointestin Liver Dis 2018 Dec;27(4):399-407

Regional Institute of Gastroenterology and Hepatology;3rd Surgical Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Aims: To report on the long-term impact of tumor and non-tumor related parameters on local recurrence, distant recurrence and survival in patients with naïve or recurrent type hepatocellular carcinoma (HCC) treated by radiofrequency ablation (RFA).

Methods: We performed 240 RFA sessions on 133 patients with 156 HCC nodules developed on a background of liver cirrhosis and analyzed the outcomes.

Results: Contrast-enhanced ultrasound performed one month after RFA showed complete ablation in 119 out of 133 (89. Read More

Arq Gastroenterol 2018 Jul-Sep;55(3):208-211

Universidade Estadual do Ceará (UECE), Faculdade de Medicina, Fortaleza, CE, Brasil.

Background: Though strongly suggestive of metastasis, focal lesions on liver scans of oncological patients require histological confirmation for the prescription of adequate treatment.

Objective: To evaluate the safety and efficacy of US-guided percutaneous core liver biopsy.

Methods: Descriptive, cross-sectional study based on secondary data from 171 patients submitted to US-guided percutaneous core liver biopsy at the diagnostic radiology service of the Ceará Cancer Institute (ICC, Brazil) between February 2010 and March 2015. Read More

Pediatr Radiol 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Radiology 3NW47, Philadelphia, PA, 19104, USA.

Background: Patients who have undergone the Fontan operation for palliation of congenital heart disease with single-ventricle pathophysiology are at high risk for developing progressive liver fibrosis. Pathological assessment from percutaneous liver biopsy is central to the management of Fontan-associated liver disease, but liver biopsy in this vulnerable population poses unique challenges and potential risks.

Objective: This retrospective study describes our experience with percutaneous liver biopsy performed to assess changes of Fontan-associated liver disease, with particular regard to procedural outcomes. Read More

Eur Radiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Interventional and Diagnostic Imaging, University Hospital of Caen, Avenue de la Côte de Nacre, 14033, Caen Cedex, France.

Purpose: This study was conducted in order to investigate the safety and accuracy of percutaneous transluminal forceps biopsy (PTFB) during percutaneous biliary drainage (PTBD) in patients with a suspicion of malignant biliary stricture.

Material And Methods: Fifty consecutive patients with obstructive jaundice underwent PTFB during PTBD. Biopsy specimens were obtained using 5. Read More

Cureus 2018 Aug 24;10(8):e3197. Epub 2018 Aug 24.

Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, USA.

Lafora disease is fatal intractable progressive myoclonic epilepsy. It is frequently characterized by epileptic seizures, difficulty walking, muscle spasms, and dementia in late childhood or adolescence. We chronicle here an unusual case of an asymptomatic young male soccer player who presented with elevated liver enzymes. Read More

Mymensingh Med J 2018 Oct;27(4):826-833

Dr Muhammad Shariful Hasan, Medical Officer, Department of Paediatric Gastroenterology & Nutrition, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Biliary atresia is the commonest cause of cholestatic jaundice. Early diagnosis & surgical correction helps long time survival & prevent development of cirrhosis. This study was conducted to find out the role of liver biopsy in the diagnosis of biliary atresia having positive hepatobiliary scintigraphy as there is chance of false positivity. Read More

JGH Open 2018 Oct 1;2(5):242-245. Epub 2018 Oct 1.

Department of Pathology University Malaya Kuala Lumpur Malaysia.

A 33-year-old man was referred with hyperosmotic symptoms of 4 weeks. Clinical examination showed palpable hepatomegaly and no stigmata of liver disease. Findings were random glucose 16. Read More

Onco Targets Ther 2018 26;11:7513-7519. Epub 2018 Oct 26.

Department of Respiratory Medicine, Peking Union Medical College Hospital, Dongcheng District, Beijing 100730, China,

Objective: Acquired T790M mutations account for 50%-60% of tyrosine kinase inhibitor (TKI)-resistant mechanisms in mutation-positive (m+) non-small-cell lung cancer (NSCLC) patients, and re-biopsy is recommended to detect these mutations. We investigated the re-biopsy status and the T790M incidence rate in patients after treatment with icotinib, which is the first-generation EGFR-TKI widely used in China.

Patients And Methods: Target patients had EGFRm+NSCLC, who were progressed after icotinib therapy. Read More

Int J Toxicol 2018 Nov 19:1091581818811306. Epub 2018 Nov 19.

4 Aclairo Pharmaceutical Development Group Inc, Vienna, VA, USA.

Regional therapies for metastatic liver disease have garnered interest in recent years due to technological advances in drug delivery. A percutaneous hepatic perfusion (PHP) using a newly developed generation 2 (GEN2) filtration system was designed to mitigate systemic toxicity and cardiovascular risk associated with hepatic blood filtration during hepatic artery infusion of the chemotherapy drug melphalan. The GEN2 system was evaluated in healthy swine, and plasma samples were assessed for clinical chemistry, melphalan toxicokinetics (TK), inflammatory cytokines, catecholamines, hematological, and cardiac biomarkers. Read More

Ann Med Surg (Lond) 2018 Dec 2;36:99-105. Epub 2018 Nov 2.

Dept. of Paediatric Surgery, PGIMS Rohtak, Haryana, India.

Cystic echinococcosis (CE) is a widely endemic helminthic disease caused by infection with metacestodes (larval stage) of the Echinococcus granulosus tapeworm and transmitted by dogs. are common parasites in certain parts of the world, and are present on every continent with the exception of Antarctica. As a result, a large number of people are affected by CE. Read More

Transplant Proc 2018 Nov 19;50(9):2882-2884. Epub 2018 Mar 19.

Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan.

The effective treatment for hepatocellular carcinoma (HCC) with American Joint Committee on Cancer stage IIIB remains controversial and challenging because of the high recurrence rate after resection and low survival rate. The median survival of those with macroscopic portal vein tumor thrombus (PVTT) is short. We reported such a case which received liver transplantation (LT) after successful consecutive downstaging therapies. Read More

Eur J Radiol 2018 Nov 19;108:133-139. Epub 2018 Sep 19.

Radiology Department, Angers University Hospital, Angers, France; HIFIH Laboratory, UPRES 3859, SFR 4208, Bretagne Loire University, Angers, France.

Objectives: Advanced chronic liver disease is frequent yet largely underdiagnosed. Doppler-US is a common examination and we recently identified three simple Doppler-US signs associated with severe liver fibrosis. Recent Doppler-US devices include elastography modules, allowing for liver stiffness measurement (LSM). Read More

Gastrointest Endosc 2019 02 31;89(2):238-246.e3. Epub 2018 Oct 31.

Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Background And Aims: EUS-guided liver biopsy (LB) is an emerging technique over conventional percutaneous (PC) or transjugular (TJ) approaches. Recent studies have reported that EUS-guided LB may have a better safety profile than PC LB or TJ LB without compromising diagnostic yield, and the outcomes are varied with respect to the types of biopsy needles. We performed a systematic review and meta-analysis to estimate the diagnostic yield, specimen adequacy, and adverse events associated with EUS-guided LB. Read More

J Viral Hepat 2019 Feb 28;26(2):297-307. Epub 2018 Nov 28.

Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, Beijing, China.

The limitations of liver biopsy have led to the development of indirect noninvasive models for liver fibrosis assessment. We aimed to evaluate and compare the performance of 30 noninvasive models to predict fibrosis stage in treatment-naïve and treated chronic hepatitis B (CHB) patients. A total of 576 Chinese treatment-naïve CHB patients and 236 treated CHB patients who had undergone percutaneous liver biopsy were included in the analysis. Read More

Radiol Case Rep 2019 Jan 28;14(1):129-132. Epub 2018 Oct 28.

Department of Diagnostic Imaging, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA.

Hemothorax is a rare complication of percutaneous needle biopsy in the chest at a rate of 0.092%. Rarer yet is diaphragm injury with herniation of intra-abdominal organs. Read More

HPB (Oxford) 2018 Oct 23. Epub 2018 Oct 23.

Department of Surgery, Amsterdam UMC, University of Amsterdam, the Netherlands.

Background: Hepatobiliary scintigraphy (HBS) is used to quantify total and regional liver function. Transient elastography (TE) provides a non-invasive alternative to percutaneous biopsy to assess liver fibrosis and cirrhosis. This study aims to determine the correlation between HBS and histopathology of liver parenchyma, and to compare these with TE in patients with resectable hepatocellular carcinoma (HCC). Read More

Eur J Gastroenterol Hepatol 2019 02;31(2):253-259

Department of Gastroenterology, Braga Hospital.

Introduction: Percutaneous liver biopsy (PLB) is an invasive procedure used for the assessment of liver diseases. The patient's recovery position after the PLB differs among hospitals and departments. This study aims to evaluate adverse events and patient acceptability according to the recovery position adopted after the PLB. Read More

J Investig Med 2019 Feb 10;67(2):303-311. Epub 2018 Oct 10.

Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, Florida, USA.

Fibromax is a diagnostic tool composed of the combination of 4 non-invasive biomarker panels for the diagnosis of steatosis (SteatoTest), necrosis and inflammation (ActiTest and NashTest-2) and fibrosis (FibroTest). The purpose of this study was to assess the performance of these biomarker panels in patients with type 2 diabetes mellitus (T2DM). All patients underwent routine labs, a 75 g oral glucose tolerance test, a liver proton magnetic resonance spectroscopy (H-MRS) to measure intrahepatic triglyceride content, and a percutaneous liver biopsy to establish the diagnosis of non-alcoholic steatohepatitis (NASH) and to grade and stage the disease in those patients with non-alcoholic fatty liver disease (NAFLD) by H-MRS. Read More

Medicine (Baltimore) 2018 Oct;97(40):e12742

Chang Gung University, College of Medicine, Taiwan.

Rationale: According to previously published studies, major complications arising from a percutaneous liver biopsy are rare and occur in less than 0.1% of cases. This report describes an approach to percutaneous liver biopsy that can help avoid damage to the liver in a living donor liver transplantation (LDLT) setting. Read More

Cureus 2018 Jul 24;10(7):e3037. Epub 2018 Jul 24.

General Surgery, Hacettepe University, Ankara, TUR.

An undifferentiated embryonal sarcoma of the liver (UESL) is a rare and highly malignant mesenchymal neoplasm that is uncommonly observed in adults. We report a case of UESL found in a 26-year-old female. Our case was initially regarded as a type II hydatid cyst and then a malignant mass in radiological studies. Read More

Case Rep Surg 2018 6;2018:9264251. Epub 2018 Sep 6.

Division of Hepato-Pancreato-Biliary Surgery, Virginia Surgery Associates, Fairfax, VA, USA.

Introduction: Reactive lymphoid hyperplasia (RLH) is a rare and benign lesion found in organs of the gastrointestinal tract, skin, lung, orbit, and more rarely in the liver. Due to its similar appearance on imaging, it is hard to differentiate from primary liver malignancies. The following is a case report of a patient presenting with a suspicious liver lesion found to be RLH associated with primary biliary cirrhosis (PBC), after surgical resection. Read More

J Cancer Res Ther 2018 Sep;14(Supplement):S628-S633

Department of Interventional Radiology, People's 10th Hospital Affiliated to Nanjing Medical University, Shanghai 200072, China.

Objective: To investigate the incidence, management, and outcome of a liver abscess after transarterial embolization/chemoembolization (TAE/TACE) therapy for hepatocellular carcinoma (HCC).

Materials And Methods: From May 2007 to May 2014, all patients complicated with liver abscess following TAE/TACE for HCC were identified and analyzed at four medical centers.

Results: During the study period, a total of 6984 TAE/TACE procedures were performed among 3129 patients, and a total of 23 patients developed liver abscess with the incidence of 0. Read More

Case Rep Gastrointest Med 2018 2;2018:1284610. Epub 2018 Sep 2.

Genesys Regional Medical Center Gastroenterology, 1 Genesys Parkway, ATTN: Medical Education, Grand Blanc, MI 48439, USA.

Percutaneous Liver Biopsy is an often-required procedure for the evaluation of multiple liver diseases. The complications are rare but well reported. Here we present a case of a 60-year-old overweight female who underwent liver biopsy for elevated alkaline phosphatase. Read More

Technol Cancer Res Treat 2018 01;17:1533033818801362

1 Center of Interventional Oncology and Liver Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China.

Aim: This study aimed to evaluate the efficacy of percutaneous thermal ablation combined with transarterial embolization for recurrent hepatocellular carcinoma after hepatectomy and establish a prognostic nomogram to predict survival.

Methods: One hundred seventeen patients with recurrent hepatocellular carcinoma receiving ablation from 2009 to 2014 were included in primary cohort to establish a prognostic nomogram. Between 2014 and 2016, 51 patients with recurrent hepatocellular carcinoma treated by ablation were enrolled in the validation cohort to validate the predictive accuracy of the nomogram. Read More

Radiol Case Rep 2018 Dec 14;13(6):1203-1206. Epub 2018 Sep 14.

Diagnostic Radiology and Nuclear Medicine Department, University of Maryland Medical Center, 33 S Greene Street, Baltimore, MD 21201, USA.

Introduction: Transjugular liver biopsy (TJLB) is a minimally invasive procedure performed to obtain hepatic tissue in patients whom standard percutaneous liver biopsy is contraindicated due to abnormal coagulation profile and/or severe ascites. Additionally, it has the advantage of simultaneously measuring the hepatic venous pressures.

Case Presentation: 61-year-old male with history of pulmonary fibrosis, cholecystectomy and Hepatitis C underwent transjugular liver biopsy (TJLB) as part of his lung transplant workup. Read More

Eur J Cancer 2018 Nov 14;103:108-119. Epub 2018 Sep 14.

Department of Interventional Radiology, Gustave Roussy, Villejuif, France; Faculté de Médecine, Kremlin-Bicêtre, Université Paris Sud, France; Laboratory of Translational Research in Immunology - LRTI, INSERM U1015, Gustave Roussy, France. Electronic address:

Purpose: To evaluate efficacy, complications and preprocedural risk factors for percutaneous image-guided core needle biopsy of malignant tumours for genomic tumour analysis.

Materials And Methods: Procedural data for core biopsies performed at a single centre for the MOSCATO-01 clinical trial were prospectively recorded between December 2011 and March 2016. Data assessed included patient demographics, tumour characteristics, procedural outcomes and complications. Read More

Surg Oncol 2018 Sep 29;27(3):415-420. Epub 2018 May 29.

Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, UK. Electronic address:

Background: Radiofrequency (RF)-assisted liver resection allows non-anatomical liver resection with reduced blood loss and offers the opportunity for a combination of resection and ablation. However, there are still concerns with regard to postoperative complications related to this technique. In the present study, we discuss the technical aspects of RF-assisted liver resections and analyse the rate of perioperative complications, focusing on post-hepatectomy liver failure (PLF), bile leak and abscess, and mortality. Read More

J Int Med Res 2018 Sep 13:300060518796760. Epub 2018 Sep 13.

Department of Infectious Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Objective Liver biopsy is the gold standard test for assessment of liver pathology. This study was performed to assess the predictive value of spleen thickness for liver pathology and the role of routine follow-up procedures in significant liver pathology for patients with chronic hepatitis B (CHB) with persistently normal alanine aminotransferase (PNALT) or minimally raised alanine aminotransferase (ALT). Methods Patients with CHB who underwent percutaneous liver biopsy were retrospectively reviewed. Read More

Anticancer Res 2018 Sep;38(9):5547-5550

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A.

Concurrent laryngeal squamous cell carcinoma and intrahepatic cholangiocarcinoma is rare and no prior report has been found through a PubMed search. Here we report such a case of a 51-year old obese male presenting with hoarseness and trouble swallowing for 2 to 3 months. Imaging findings of computer tomography (CT) and magnetic resonance imaging (MRI) with and without contrast were suspicious for a T3N2 supraglottic laryngeal cancer. Read More

Medicine (Baltimore) 2018 Aug;97(35):e11618

Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Percutaneous microwave ablation therapy (PMCT) has been recommended for elderly hepatocellular carcinoma (HCC) patients who cannot tolerate surgery due to their age or presence of comorbidities. Few studies have investigated efficacy and treatment outcomes for PMCT treatment in these patients, especially in China, where patients are more often diagnosed and treated early in life. This study evaluated the safety and efficacy of ultrasound-guided PMCT in treatment-naive elderly HCC patients, and analyzed risk factors associated with poor treatment outcomes. Read More

Dig Dis 2018 28;36(6):446-449. Epub 2018 Aug 28.

Recently, due to improvement of imaging modality, malignant tumor such as pancreatic or bile duct cancer can be detected at earlier stage. Therefore, the frequency of surgical treatment may be increasing. According to this background, benign biliary stricture in anastomosis site may also be increasing. Read More

Int J Surg Case Rep 2018 13;51:45-49. Epub 2018 Aug 13.

Department of Surgery, Saga Medical Center Koseikan, Saga, Japan.

Introduction: Undifferentiated carcinoma of the liver is extremely rare. The biological characteristics and standard strategy for its treatment have not been established yet.

Presentation Of Case: A 45-year-old man was admitted because of fever elevation and shivering. Read More

Eur J Radiol Open 2018 21;5:121-125. Epub 2018 Aug 21.

University Medical Centre Ljubljana, Clinical Institute of Radiology, Ljubljana, Slovenia.

Perivascular epithelioid cell tumor (PEComa) of liver is extremely rare hepatic neoplasm with only 30 cases reported in the literature. These lesions are found mainly in young females and may present a potential pitfall in the characterisation of focal liver lesions. The biological behavior of PEComa varies from generally benign to rarely malignant and metastatic disease. Read More

BMC Cancer 2018 Aug 23;18(1):844. Epub 2018 Aug 23.

Department of General Surgery and Liver Transplantation, Hospices Civils de Lyon, Croix-Rousse University Hospital, 103, Grande Rue de la Croix-Rousse, 69317, Lyon Cedex 04, France.

Background: The majority of patients undergoing hepatectomy for hepatocellular carcinoma (HCC) suffer from underlying liver disease and are exposed to the risk of postoperative ascites, which is favored by an imbalance between portal venous inflow and a diminished hepatic volume. Finding a reversible, non-invasive method for modulating the portal inflow would be of interest as it could be used temporarily during the early postoperative course. Somatostatin, a well-known drug already used in several indications, may limit the risk of postoperative ascites and liver failure by decreasing portal pressure after hepatectomy for HCC in patients with underlying liver disease. Read More

Lancet Gastroenterol Hepatol 2018 Oct 17;3(10):681-690. Epub 2018 Aug 17.

Department of Surgery, Amsterdam University Medical Center, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands. Electronic address:

Background: In patients with resectable perihilar cholangiocarcinoma, biliary drainage is recommended to treat obstructive jaundice and optimise the clinical condition before liver resection. Little evidence exists on the preferred initial method of biliary drainage. We therefore investigated the incidence of severe drainage-related complications of endoscopic biliary drainage or percutaneous transhepatic biliary drainage in patients with potentially resectable perihilar cholangiocarcinoma. Read More