71,306 results match your criteria Percutaneous Coronary Intervention

Expression of versican mRNA transcript to predict cardiac remodelling after myocardial infarction.

Kardiol Pol 2021 Jun 24. Epub 2021 Jun 24.

1st Chair and Department of Cardiology, Medical University of Warsaw, Warszawa, Poland.

Background: Adverse left-ventricular remodelling (LVR) is defined as an increase in end-diastolic left-ventricular volume by 20% 6 months after acute myocardial infarction (AMI). LVR is associated with cardiac dysfunction, therefore deteriorating the prognosis.

Aims: We aimed to compare the concentrations of messenger RNA transcripts in the peripheral blood of patients with and without LVR at 6 months. Read More

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[Cardiac ruptures in acute myocardial infarction].

Angiol Sosud Khir 2021 ;27(2):185-192

Department of General Surgery, Kursk State Medical University of the FR Ministry of Public Health, Kursk, Russia.

Presented in the article are the generalized data of the Russian and foreign literature addressing the currently important problem of myocardial ruptures as one of the most dangerous complications of infarction, also analysing the results of clinical studies on interconnection of heart ruptures with systemic thrombolytic therapy and with a percutaneous coronary intervention. This is followed by describing the mechanisms that may lead to myocardial rupture during thrombolytic therapy and surgical endovascular treatment, underlying the necessity of pharmacological pre- and post-conditioning for prevention of reperfusion myocardial lesions. The article also touches upon the clinical and instrumental diagnosis of myocardial ruptures, as well as approaches to surgical treatment depending on the type of rupture and necessity of myocardial revascularization. Read More

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January 2021

[Redo surgery of carotid arteries in patients with contraindications to carotid angioplasty and stenting].

Angiol Sosud Khir 2021 ;27(2):92-98

Kemerovo State Medical University of the RF Ministry of Public Health, Kemerovo, Russia.

Aim: The study was aimed at analysing the in-hospital results of carotid re-endarterectomy and plasty of the zone of reconstruction with a biological patch in patients with haemodynamically significant restenosis and contraindications to carotid angioplasty with stenting.

Patients And Methods: During the period from 2008 to 2019, we operated on a total of 22 patients presenting with carotid restenosis and found to have contraindications to carotid angioplasty with stenting (an extended lesion, unstable neointima, calcification, pronounced tortuosity). Carotid re-endarterectomy was performed according to the classical technique. Read More

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January 2021

Increased Risk of Adverse Cardiovascular Events by Strict Glycemic Control after Percutaneous Coronary Intervention (HbA1c < 6.5% at 2 Years) in Type 2 Diabetes Mellitus Combined with Acute Coronary Syndrome: a 5-years follow-up study.

Curr Med Res Opin 2021 Jun 24. Epub 2021 Jun 24.

Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110000.

This study assessed the association between HbA1c level measured 2 years after percutaneous coronary intervention (PCI) and long-term clinical outcomes in type 2 diabetes mellitus combined with acute coronary syndrome (ACS) who underwent PCI. This prospective observational study analyzed 2877 ACS patients with type 2 diabetes mellitus whose baseline HbA1c ≥ 7.0% and underwent PCI. Read More

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Ticagrelor effectively inhibits platelet aggregation in comatose survivors of cardiac arrest undergoing primary percutaneous coronary intervention treated with mild therapeutic hypothermia.

Cardiol J 2021 Jun 24. Epub 2021 Jun 24.

Jagiellonian University Medical College Institute of Cardiology, Department of Interventional Cardiology, Krakow, Poland.

Background: Mild therapeutic hypothermia (MTH) is believed to reduce the effectiveness of antiplatelet drugs. Effective dual-antiplatelet therapy after percutaneous coronary intervention (PCI) is mandatory to avoid acute stent thrombosis (ST). The effectiveness of ticagrelor in MTH-treated out-of-hospital cardiac arrest (OHCA) survivors is still a matter of debate. Read More

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The effects of polymorphisms in CYP2C19, ATP-binding cassette transporter B1, and paraoxonase-1 on clopidogrel treatment of Uygur patients following percutaneous coronary intervention.

Eur J Clin Pharmacol 2021 Jun 23. Epub 2021 Jun 23.

Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, 830001, China.

Background: Acute coronary syndrome (ACS) carries a high mortality in Uygur populations. Percutaneous coronary intervention (PCI) is a safe treatment for patients with ACS. Clopidogrel reduces the risk for recurrent cardiovascular events after PCI; however, its activity is influenced by cytochrome P450 (CYP450), ATP-binding cassette transporter B1 (ABCB1), and paraoxonase-1 (PON1). Read More

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Release Profile of Cardiac Troponin T and Risk Factors of Postoperative Myocardial Injury in Patients Undergoing CABG.

Int J Gen Med 2021 15;14:2541-2551. Epub 2021 Jun 15.

Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.

Background: Cardiac troponin T (cTnT) is currently one of the important indicators for clinical diagnosis of myocardial injury, which is inevitable in cardiac surgery, especially coronary artery bypass grafting (CABG). Describing the release profile of cTnT and finding out the risk factors of postoperative myocardial injury (PMI) are of great significance. The purposes of this study are to explore the release profile of cTnT in patients undergoing CABG and to search for independent risk factors of PMI. Read More

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One-Year Outcome After Percutaneous Coronary Intervention for Acute Coronary Syndrome - An Analysis of 20,042 Patients From a Japanese Nationwide Registry.

Circ J 2021 Jun 24. Epub 2021 Jun 24.

Division of Cardiovascular Medicine, Toho University Ohashi Medical Center.

Background: Acute coronary syndrome (ACS) hospital survivors experience a wide array of late adverse cardiac events, despite considerable advances in the quality of care. We investigated 30-day and 1-year outcomes of ACS hospital survivors using a Japanese nationwide cohort.Methods and Results:We studied 20,042 ACS patients who underwent percutaneous coronary intervention (PCI) in 2017: 10,242 (51%) with ST-elevation myocardial infarction (STEMI), 3,027 (15%) with non-ST-elevation myocardial infarction (NSTEMI), and 6,773 (34%) with unstable angina (UA). Read More

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Post PCI severe gastrointestinal bleeding in the setting of idiopathic thrombocytopenic purpura: a treatment dilemma.

BMJ Case Rep 2021 Jun 23;14(6). Epub 2021 Jun 23.

Department of Cardiology, Saint Vincent Hospital, Worcester, Massachusetts, USA.

Gastrointestinal (GI) bleeding is a serious complication encountered commonly in patients on chronic anticoagulation and/or antiplatelet agents. There is a lack of guidelines on how to manage antiplatelet/anticoagulant therapy in patients with thrombocytopenia and GI bleeding. This poses a clinical dilemma when a clinician encounters serious GI bleeding in clinical practice. Read More

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Endothelial Recovery in Bare Metal Stents and Drug-Eluting Stents on a Single-Cell Level.

Arterioscler Thromb Vasc Biol 2021 Jun 24:ATVBAHA121316472. Epub 2021 Jun 24.

CVPath Institute, Gaithersburg, MD (A.C., L.G., R.F., C.J., S.K., A.S., H.J., Y.S., K.H.P., F.D.K., M.E.R., D.S., R.V., A.V.F.).

Objective: Healing processes, particularly reendothelialization, are essential for vascular homeostasis after plain old balloon angioplasty and stent implantation. Drug-eluting stents (DES) are commonly used for percutaneous coronary intervention because restenosis rates are reduced as compared with bare metal stents. However, in addition to understanding the nature of regenerated endothelial cells, concerns over incomplete stent healing persist, and the molecular effects of antiproliferative drug coatings on endothelium remain poorly understood. Read More

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High-dose statin pretreatment decreases periprocedural myocardial infarction and cardiovascular events in East Asian patients undergoing percutaneous coronary intervention: A meta-analysis of fifteen randomized controlled trials.

Medicine (Baltimore) 2021 Jun;100(25):e26278

Department of Cardiology, Institute of Cardiovascular Disease, Peking University First Hospital, Beijing, China.

Background: Numerous studies have shown that high-dose statin pretreatment may reduce the risk of periprocedural myocardial infarction (PMI) and short-term major adverse cardiac events (MACE) in western people undergoing percutaneous coronary intervention (PCI). However, the effects in East Asian patients are still controversial. The objective was to evaluate the effects of short-term high-dose statin (all types) pretreatment compared with the control (low-dose or no statin) on the reduction of the rate of MACE and PMI in East Asian patients. Read More

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New genetic variants associated with major adverse cardiovascular events in patients with acute coronary syndromes and treated with clopidogrel and aspirin.

Pharmacogenomics J 2021 Jun 22. Epub 2021 Jun 22.

Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Although a few studies have reported the effects of several polymorphisms on major adverse cardiovascular events (MACE) in patients with acute coronary syndromes (ACS) and those undergoing percutaneous coronary intervention (PCI), these genotypes account for only a small fraction of the variation and evidence is insufficient. This study aims to identify new genetic variants associated with MACE end point during the 18-month follow-up period by a two-stage large-scale sequencing data, including high-depth whole exome sequencing of 168 patients in the discovery cohort and high-depth targeted sequencing of 1793 patients in the replication cohort. We discovered eight new genotypes and their genes associated with MACE in patients with ACS, including MYOM2 (rs17064642), WDR24 (rs11640115), NECAB1 (rs74569896), EFR3A (rs4736529), AGAP3 (rs75750968), ZDHHC3 (rs3749187), ECHS1 (rs140410716), and KRTAP10-4 (rs201441480). Read More

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Quality of acute myocardial infarction care in England and Wales during the COVID-19 pandemic: linked nationwide cohort study.

BMJ Qual Saf 2021 Jun 22. Epub 2021 Jun 22.

Leeds Institute for Data analytics, University of Leeds, Leeds, UK.

Background And Objective: The impact of the COVID-19 pandemic on the quality of care for patients with acute myocardial infarction (AMI) is uncertain. We aimed to compare quality of AMI care in England and Wales during and before the COVID-19 pandemic using the 2020 European Society of Cardiology Association for Acute Cardiovascular Care quality indicators (QIs) for AMI.

Methods: Cohort study of linked data from the AMI and the percutaneous coronary intervention registries in England and Wales between 1 January 2017 and 27 May 2020 (representing 236 743 patients from 186 hospitals). Read More

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Role of 2-dimensional speckle tracking echocardiography in diagnosis of right ventricular involvement in patients with inferior wall myocardial infarction undergoing primary percutaneous coronary intervention.

Int J Cardiovasc Imaging 2021 Jun 22. Epub 2021 Jun 22.

Department of Cardiovascular Medicine, Assiut University Heart Hospital, Assiut University, Assiut, Egypt.

Diagnosis of right ventricular (RV) infarction in the setting of acute inferior wall myocardial infarction (IWMI) has important prognostic implications. We sought to assess the role of 2-D speckle tracking echocardiography (2-D STE) for the assessment of RV involvement in acute IWMI. We included 100 consecutive patients with a diagnosis of recent IWMI, of which 73 had an RCA culprit lesion, undergoing primary percutaneous coronary intervention (PPCI). Read More

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Gender differences in patients presenting with non-ST segment elevation myocardial infarction in the STAR registry.

Egypt Heart J 2021 Jun 22;73(1):54. Epub 2021 Jun 22.

Department of Cardiology, King Saud Bin Abdulaziz University for Health Sciences, College of medicine, King Abdullah International Medical Research Center, Ministry of National Guard-Health Affairs, Jeddah, Saudi Arabia.

Background: In most acute coronary artery (ACS) related literature, the female gender constitutes a smaller proportion. This study is based on gender-specific data in the Saudi Acute Myocardial Infarction Registry Program (STARS-1 Program). A prospective multicenter study, conducted with patients diagnosed with ACS in 50 participating hospitals. Read More

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Remote proctoring for high-risk coronary interventions with mechanical circulatory support during COVID-19 pandemic and beyond.

Clin Res Cardiol 2021 Jun 22. Epub 2021 Jun 22.

Herzzentrum Dresden, Department of Internal Medicine and Cardiology, Technische Universität Dresden, Fetscherstr. 76, 01307, Dresden, Germany.

Remote proctoring by advanced digital technologies may help to overcome pandemic, geographic, and resource-related constraints for mentoring and educating interventional cardiology skills. We present a case series of patients undergoing high-risk percutaneous coronary intervention (HR-PCI) with mechanical circulatory support (MCS) guided by remote proctoring to gain insights into a streaming technology platform with regard to video/audio quality, visibility of all structural and imaging details, and delay in transmission. According to our experience, remote proctoring appears to be a reliable, quick, and resource-conserving way to disseminate, educate and improve MCS-supported HR-PCI with implications far beyond the COVID-19 pandemic. Read More

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Ten-year clinical outcomes of polymer-free versus durable polymer new-generation drug-eluting stent in patients with coronary artery disease with and without diabetes mellitus : Results of the Intracoronary Stenting and Angiographic Results: Test Efficacy of Sirolimus- and Probucol- and Zotarolimus-Eluting Stents (ISAR-TEST 5) trial.

Clin Res Cardiol 2021 Jun 22. Epub 2021 Jun 22.

Deutsches Herzzentrum München, Klinik Für Herz- Und Kreislauferkrankungen, an der Technischen Universität München, Lazarettstrasse 36, 80636, Munich, Germany.

Background: Very long-term outcomes according to diabetic status of patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) with new-generation drug-eluting stents (DES) are scant. Both, the durable polymer zotarolimus-eluting stent (DP-ZES), the first DES to gain FDA-approval for specific use in patients with diabetes mellitus, and the polymer-free sirolimus- and probucol-eluting stent (PF-SES), with a unique design that enables effective drug release without the need of a polymer offer the potential to enhance clinical long-term outcomes especially in patients with diabetes mellitus.

Methods: We investigate 10-year clinical outcomes of the prespecified subgroups of patients with and without diabetes mellitus, randomly assigned to treatment with PF-SES versus DP-ZES in the ISAR-TEST 5 trial. Read More

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Sex Differences in Prehospital Delays in Patients With ST-Segment-Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention.

J Am Heart Assoc 2021 Jun 22:e019938. Epub 2021 Jun 22.

School of Clinical Sciences at Monash Health Monash Cardiovascular Research Centre Monash University Melbourne Australia.

Background Women with ST-segment-elevation myocardial infarction experience delays in reperfusion compared with men with little data on each time component from symptom onset to reperfusion. This study analyzed sex discrepancies in patient delays, prehospital system delays, and hospital delays. Methods and Results Consecutive patients with ST-segment-elevation myocardial infarction treated with percutaneous coronary intervention across 30 hospitals in the Victorian Cardiac Outcomes Registry (2013-2018) were analyzed. Read More

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Intra-aortic balloon pump on in-hospital outcomes of cardiogenic shock: findings from a nationwide registry, China.

ESC Heart Fail 2021 Jun 21. Epub 2021 Jun 21.

Peking University First Hospital, Beijing, China.

Aims: The real-world usage of intra-aortic balloon pump (IABP) in various cardiogenic shocks (CS) and the association with outcomes are lacking. We aimed to investigate IABP adoption in CS in a nationwide registry in China.

Methods And Results: We retrospectively retrieved data of 30 106 CS patients (age 67. Read More

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Comparison of radial versus femoral access using hemostatic devices following percutaneous coronary intervention.

Indian Heart J 2021 May-Jun;73(3):382-384. Epub 2021 May 4.

Department of Cardiology, Post Graduate Institute of Medical Education & Research, Chandigarh-160012, India.

Arterial access site complications are the important predictor of successful percutaneous coronary interventions (PCI). We prospectively studied 722 consecutive PCI patients for access site complications. A total of 303 trans-femoral access (TFA) patients who had suture based vascular closure devices (VCD) were compared with 419 transradial access (TRA) patients. Read More

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Outcomes of transulnar and transradial percutaneous coronary intervention using ultrasound guided access in patients selected based on an ultrasound algorithm.

Indian Heart J 2021 May-Jun;73(3):362-364. Epub 2021 Mar 17.

Division of Cardiovascular Medicine, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, TX, 79905, USA.

We performed a prospective observational study of 215 patients (58 ± 11 years) and compared the outcomes of ultrasound guided ulnar (n = 98, 45.6%) vs. radial (n = 117, 54. Read More

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Safety and effectiveness of percutaneous coronary intervention using rotational atherectomy and new-generation drug-eluting stents for calcified coronary artery lesions in patients with chronic kidney disease.

Indian Heart J 2021 May-Jun;73(3):342-346. Epub 2021 Apr 28.

Department of Cardiology, National Heart Foundation Hospital & Research Institute, Bangladesh.

Aim: Coronary artery calcification is an important factor influencing revascularisation outcomes in patients with chronic kidney disease (CKD). Lesion preparation using rotational atherectomy (RA) may help adequately modify calcified plaques and facilitate the achievement of optimal clinical outcomes in these patients. In this study, we assessed the safety and effectiveness of percutaneous coronary intervention (PCI) using RA followed by new-generation drug-eluting stent (DES) implantation in patients with CKD and calcified coronary artery disease (CAD). Read More

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Epidemiological and clinical profile, management and outcomes of young patients (≤40 years) with acute coronary syndrome: A single tertiary care center study.

Indian Heart J 2021 May-Jun;73(3):295-300. Epub 2021 Jan 17.

Department of Cardiology, Post Graduate Institute of Medical Education & Research, Chandigarh, 160012, India. Electronic address:

Objective: To study the epidemiological and clinical profile, angiographic patterns, reasons for the delay in presentation, management, and outcomes of the acute coronary syndrome (ACS) in young patients (≤40yrs) presenting to a tertiary care hospital in North India.

Methods: We included a total of 182 patients aged ≤40 years and presenting with ACS to the cardiology critical care unit of our department from January 2018 to July 2019.

Results: The mean age of the study population was 35. Read More

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January 2021

CYP2C19 genotype-directed PY inhibitor antiplatelet therapy normalizes risk for major adverse cardiovascular events after percutaneous coronary intervention.

Indian Heart J 2021 May-Jun;73(3):281-288. Epub 2021 Mar 17.

Sanford Heart Hospital, Sanford Cardiovascular Institute, University of South Dakota Sanford School of Medicine, Sioux Falls, SD, USA.

Objective: To study the use of CYP2C19 genotyping to guide P2Y inhibitor selection to maximize efficacy, and attenuate risk in appropriate patients who underwent PCI for CAD.

Methods: We performed a retrospective analysis of 868 patients with CAD who received CYP2C19 genotyping after PCI and changed P2Y inhibitor based on the results. Patients were divided into two groups based on clopidogrel metabolizer status. Read More

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Efficacy and safety of ticagrelor versus clopidogrel with different dosages in acute coronary syndrome patients with high GRACE and CRUSADE scores.

Indian Heart J 2021 May-Jun;73(3):273-280. Epub 2021 Feb 10.

Department of Cardiology, Fuling Central Hospital, Chongqing, China. Electronic address:

Objective: To investigate the efficacy and safety of ticagrelor and different dosages of clopidogrel after acute coronary syndrome.

Methods: We compared different antiplatelet strategies for the prevention of cardiovascular events in 1939 patients admitted to the hospital with an acute coronary syndrome undergoing percutaneous coronary intervention (PCI).

Results: At 24 months, a survival analysis showed that ticagrelor and double-dose clopidogrel decreased the incidence of MACCE (a composite of all-cause death, myocardial infarction (MI), target vessel revascularization and stroke) (p < 0. Read More

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February 2021

Factors associated with microvascular occlusion in patients with ST elevation myocardial infarction after primary percutaneous coronary intervention.

J Int Med Res 2021 Jun;49(6):3000605211024490

Department of Cardiology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China.

Objective: This study aimed to determine predictors of microvascular occlusion (MVO) in patients with ST elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (pPCI).

Methods: This retrospective, observational study consecutively included 113 patients with STEMI undergoing pPCI. Cardiac magnetic resonance imaging was used to determine the presence of MVO in these patients. Read More

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The Predictive Value of Lp(a) for Adverse Cardiovascular Event in ACS Patients With an Achieved LDL-C Target at Follow Up After PCI.

J Cardiovasc Transl Res 2021 Jun 21. Epub 2021 Jun 21.

Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

Low-density lipoprotein cholesterol (LDL-C) is a traditional and important risk factor for atherosclerotic cardiovascular disease (CVD). Recently, lipoprotein (a) (lp(a)) attracts considerable attention as a residual risk factor for CVD. However, the roles of lp(a) in acute coronary syndrome (ACS) patients with well-controlled LDL-C (≤1. Read More

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A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction.

ACS Nano 2021 Jun 21. Epub 2021 Jun 21.

Department of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina 27607, United States.

Myocardial infarction (MI) remains the most common cause of death worldwide. Many MI survivors will suffer from recurrent heart failure (HF), which has been recognized as a determinant of adverse prognosis. Despite the success of improved early survival after MI by primary percutaneous coronary intervention, HF after MI is becoming the major driver of late morbidity, mortality, and healthcare costs. Read More

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