60,961 results match your criteria Percutaneous Coronary Intervention


Adverse events in patients with high platelet reactivity following successful chronic total occlusion PCI: The Assessment of Dual AntiPlatelet Therapy with Drug-Eluting Stents (ADAPT-DES) study.

Am Heart J 2019 Feb 20;211:68-76. Epub 2019 Feb 20.

New York-Presbyterian Hospital/Columbia University Medical Center, New York, NY; Cardiovascular Research Foundation, New York, NY.

Background: Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) typically requires a greater number of stents and longer stent length than non-CTO PCI, placing these patients at greater risk for adverse ischemic events. We sought to determine whether the association between high platelet reactivity (HPR) and the risk of ischemic events is stronger after CTO than non-CTO PCI.

Methods: Patients undergoing successful PCI in the multicenter ADAPT-DES study were stratified according to whether they underwent PCI of a CTO. Read More

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http://dx.doi.org/10.1016/j.ahj.2019.02.002DOI Listing
February 2019

Serum YKL-40 predicts long-term outcome in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction.

Medicine (Baltimore) 2019 Mar;98(12):e14920

Department of Intensive Care Unit.

Serum YKL-40, a potential inflammatory marker, is greatly increased at the early stage of ST-segment elevation myocardial infarction (STEMI). Here, we hypothesized that YKL-40 levels at admission could predict the long-term outcomes after STEMI.A total of 324 patients with acute STEMI undergoing primary percutaneous coronary intervention (PCI) were consecutively enrolled and followed for 24 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000014920DOI Listing

Novel ultra-long (48 mm) everolimus-eluting stent for diffusely disease coronary vessels.

Minerva Cardioangiol 2019 Mar 19. Epub 2019 Mar 19.

Institute of Cardiology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy.

Background: Long drug-eluting stents may limit the need of stent overlaps in patients with diffusely diseased coronary arteries. We evaluated the clinical results of percutaneous-coronary- intervention (PCI) using a novel ultra-long (48 mm) everolimus-eluting stent (EES) in a real- word population.

Methods: Patients who underwent PCI with 48 mm EES between June 2015 and April 2017 in our centre were enrolled. Read More

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http://dx.doi.org/10.23736/S0026-4725.19.04879-5DOI Listing

Management of aspirin intolerance in patients undergoing percutaneous coronary intervention: the role of mono-antiplatelet therapy. A retrospective, multicenter, study.

Minerva Cardioangiol 2019 Mar 18. Epub 2019 Mar 18.

Division of Cardiology, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.

Background: The optimal management of patients with aspirin intolerance undergoing stent implantation represents a challenge for physicians. The aim of this study was to assess the overall number of patients discharged with mono anti-platelet therapy after PCI, the most frequent aspirin intolerance symptoms in this population and the overall incidence of patient oriented composite end-points (POCE).

Methods: From January 2006 to June 2016 all patients discharged with mono-antiplatelet therapy because of aspirin intolerance/hypersensitivity/allergy and treated by means of PCI were included. Read More

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http://dx.doi.org/10.23736/S0026-4725.19.04787-XDOI Listing

Two-part models for cost with zeros to decompose effects of covariates on probability of cost, mean nonzero cost, and mean total cost.

Stat Med 2019 Mar 20. Epub 2019 Mar 20.

VA Center of Innovation for Veteran-Centered and Value-Driven Care, VA Eastern Colorado Health Care System, Denver, Colorado.

Health care cost data often contain many zero values, for patients who did not use any care. Two-part models with logistic models for part I, probability of use (ie, nonzero cost) and log-link models for part II, mean cost of use (ie, nonzero cost) are often used. Effects of exposures or covariates on total (marginal) cost are often of interest, and recent work has proposed useful methods. Read More

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http://dx.doi.org/10.1002/sim.8140DOI Listing

Incidence, angiographic and clinical predictors, and impact of stent thrombosis: a 6-year survey of 6,545 consecutive patients.

Neth Heart J 2019 Mar 20. Epub 2019 Mar 20.

Department of Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands.

Objective: We sought to determine the incidence, angiographic predictors, and impact of stent thrombosis (ST).

Background: Given the high mortality after ST, this study emphasises the importance of ongoing efforts to identify angiographic predictors of ST.

Methods: All consecutive patients with angiographically confirmed ST between 2010 and 2016 were 1:4 matched for (1) percutaneous coronary intervention (PCI) indication and (2) index date ±6 weeks to randomly selected controls. Read More

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http://dx.doi.org/10.1007/s12471-019-1253-2DOI Listing

Anti-Anginal Medication Titration Among Patients with Residual Angina 6-Months After Chronic Total Occlusion Percutaneous Coronary Intervention: Insights from OPEN CTO Registry.

Eur Heart J Qual Care Clin Outcomes 2019 Mar 21. Epub 2019 Mar 21.

University of Missouri-Kansas City, Kansas City, MO.

Background: Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has been shown to reduce angina and improve quality of life, but the frequency of new or residual angina after CTO PCI and its relationship with titration of anti-anginal medications (AAM) has not been described.

Methods: Among consecutive CTO PCI patients treated at 12 U.S. Read More

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http://dx.doi.org/10.1093/ehjqcco/qcz015DOI Listing

Safety and Efficacy of Triple Antithrombotic Therapy with Dabigatran versus Vitamin K Antagonist in Atrial Fibrillation Patients: A Pilot Study.

Biomed Res Int 2019 13;2019:5473240. Epub 2019 Feb 13.

Chair of Cardiology, University of Campania "Luigi Vanvitelli", Naples, Italy.

Background: Combination of dual antiplatelet (DAPT) and oral anticoagulation therapy is required to decrease cardioembolic stroke and stent thrombosis risk in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS). We compared the safety and efficacy of dabigatran etexilate with vitamin K antagonist (VKA), in combination with DAPT (aspirin plus clopidogrel) treatment in AF patients who underwent percutaneous coronary intervention (PCI) with stenting for ACS.

Methods: Consecutive nonvalvular AF patients who received twice-daily dabigatran 110 mg (n = 389) or VKA (n = 510) and DAPT were included. Read More

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http://dx.doi.org/10.1155/2019/5473240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393928PMC
February 2019

Sonothrombolysis in ST-segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention.

J Am Coll Cardiol 2019 Mar 7. Epub 2019 Mar 7.

University of Nebraska Medical Center, Omaha, NE. Electronic address:

Background: Pre-clinical studies have demonstrated that high mechanical index (MI) impulses from a diagnostic ultrasound transducer (DUS) during an intravenous microbubble infusion (Sonothrombolysis) can restore epicardial and microvascular flow in acute ST-segment elevation myocardial infarction (STEMI).

Objective: We tested the clinical effectiveness of sonothrombolysis in patients with STEMI.

Methods: Patients with their first STEMI were prospectively randomized to either DUS-guided high MI impulses during an intravenous ultrasound agent infusion prior to, and following, emergent percutaneous coronary intervention (PCI), or to a control group that received PCI only (n=50 in each group). Read More

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http://dx.doi.org/10.1016/j.jacc.2019.03.006DOI Listing

Successful bailout procedure for acute popliteal artery occlusion associated with EXOSEAL® vascular closure device: a case report.

J Med Case Rep 2019 Mar 21;13(1):90. Epub 2019 Mar 21.

Department of Cardiovascular Medicine, Kyoto Chubu Medical Center, 25, Yagi-Ueno, Yagi-cho, Nantan, Japan.

Background: Vascular closure devices have been widely used to achieve rapid hemostasis after percutaneous catheterization procedures via the common femoral artery. The EXOSEAL vascular closure device is a device that can deliver a bioabsorbable polyglycolic acid plug to fill the subcutaneous puncture route at the groin for rapid hemostasis, and this device has a lower risk of arterial occlusion than other vascular closure devices.

Case Presentation: An 83-year-old Japanese man underwent percutaneous coronary intervention for a proximal stenosis in his left circumflex artery through a 7-Fr sheath from his right common femoral artery. Read More

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http://dx.doi.org/10.1186/s13256-018-1950-2DOI Listing

Mineralocorticoid receptor antagonist pre-treatment and early post-treatment to minimize reperfusion injury after ST-elevation myocardial infarction: The MINIMIZE STEMI trial.

Am Heart J 2019 Feb 20;211:60-67. Epub 2019 Feb 20.

Hatter Cardiovascular Institute, London, United Kingdom; Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom; The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, United Kingdom; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore; Yong Loo Lin School of Medicine, National University Singapore, Singapore; Tecnologico de Monterrey, Centro de Biotecnologia-FEMSA, Nuevo Leon, Mexico. Electronic address:

Background: Mineralocorticoid receptor antagonist (MRA) therapy has been shown to prevent adverse left ventricular (LV) remodeling in ST-segment elevation myocardial infarction (STEMI) patients with heart failure. Whether initiating MRA therapy prior to primary percutaneous coronary intervention (PPCI) accrues additional benefit of reducing myocardial infarct size and preventing adverse LV remodeling is not known. We aimed to investigate whether MRA therapy initiated prior to reperfusion reduces myocardial infarct (MI) size and prevents adverse LV remodeling in STEMI patients. Read More

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http://dx.doi.org/10.1016/j.ahj.2019.02.005DOI Listing
February 2019

Analysis of the Appropriate Use Criteria for Coronary Angiography in Two Cardiology Services of Southern Brazil.

Arq Bras Cardiol 2019 Mar 14. Epub 2019 Mar 14.

Instituto de Cardiologia de Santa Catarina, São José, SC - Brazil.

Background: Despite its great relevance, there are no studies in our country evaluating the application of the 2012 guidelines for the appropriate use of cardiac diagnostic catheterization.

Objective: To analyze the adequacy of coronary angiography performed in two hospitals in the southern region of Brazil.

Methods: This is a multicenter cross-sectional study, which analyzed indications, results and proposals for the treatment of 737 coronary angiograms performed in a tertiary hospital with multiple specialties (Hospital A) and a tertiary cardiology hospital (Hospital B). Read More

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http://dx.doi.org/10.5935/abc.20190055DOI Listing

Ticagrelor for patients with ST-segment elevation myocardial infarction after emergency percutaneous coronary intervention.

J Biol Regul Homeost Agents 2019 Mar 20;33(2). Epub 2019 Mar 20.

Ward II of Cardiovascular Department, Zhengzhou Central Hospital Affiliated to Zhengzhou University, ZhengZhou, China.

Acute ST-segment elevation myocardial infarction (STEMI) is one of the most common cardiovascular emergencies. With the improvement of living standards, the incidence and mortality rate of STEMI has shown a significant growth trend. Read More

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The Proximal Optimization Technique Improves Clinical Outcomes When Treated without Kissing Ballooning in Patients with a Bifurcation Lesion.

Korean Circ J 2019 Feb 22. Epub 2019 Feb 22.

Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background And Objectives: There are limited data regarding the clinical efficacy of the proximal optimization technique (POT) in the treatment of coronary bifurcation lesions. We investigated the influence of POT on the clinical outcomes of patients with coronary bifurcation lesions.

Methods: We enrolled a total of 1,191 patients with a bifurcation lesion with a side branch (SB) diameter ≥2. Read More

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http://dx.doi.org/10.4070/kcj.2018.0352DOI Listing
February 2019

Ticagrelor-induced Angioedema After Percutaneous Coronary Intervention in a Patient with a History of Ischemic Stroke and Low Response to Clopidogrel: A Rare Dilemma.

Cureus 2018 Dec 11;10(12):e3720. Epub 2018 Dec 11.

Cardiology, Saint Vincent Hospital, Worcester, USA.

Dual antiplatelet therapy (DAPT) is widely recognized as the mainstay of treatment after percutaneous coronary intervention (PCI). Premature discontinuation may pose a risk of in-stent thrombosis, acute myocardial infarction, and death. With the increased usage of antiplatelet agents, increased attention has been drawn to their potential allergic reactions. Read More

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http://dx.doi.org/10.7759/cureus.3720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415980PMC
December 2018

Pharmacodynamic changes of platelet reactivity status in patients with chronic kidney disease after coronary artery stenting.

Biomed Pharmacother 2019 Mar 16;113:108773. Epub 2019 Mar 16.

Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Objectives: This study was to evaluate platelet reactivity over time among patients with chronic kidney disease (CKD) receiving standard dose of clopidogrel after percutaneous coronary intervention (PCI). The effect of CYP2C19 loss-of-function genotypes on platelet reactivity was also determined.

Methods: Patients with CKD (n = 138) on maintenance dose of clopidogrel after PCI were enrolled. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108773DOI Listing

Patient-oriented composite endpoints and net adverse clinical events with ticagrelor monotherapy following percutaneous coronary intervention: Insights from the randomized GLOBAL LEADERS trial.

EuroIntervention 2019 Mar 19. Epub 2019 Mar 19.

NHLI, Imperial College London, London, United Kingdom, United Kingdom.

Aims: To evaluate the impact of 23-month ticagrelor monotherapy following one-month dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) on the rates of patient-oriented composite endpoints (POCE) and net adverse clinical events (NACE).

Methods And Results: The rates of site-reported Academic Research Consortium (ARC)-2 defined POCE (all-cause death, any stroke, any myocardial infarction or any revascularization) and NACE (POCE or bleeding type 3 or 5 according to the Bleeding ARC [BARC]) were reported up to two-years by intention-to-treat principle in the randomized, multi-centre, open-label GLOBAL LEADERS study comparing two antiplatelet strategies in 15,991 patients undergoing PCI. The experimental strategy consisted of aspirin with ticagrelor for one month followed by ticagrelor monotherapy for 23 months, whereas the reference treatment consisted of 12-month DAPT followed by 12-month aspirin monotherapy. Read More

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http://dx.doi.org/10.4244/EIJ-D-19-00202DOI Listing
March 2019
3.769 Impact Factor

Safety and efficacy of the novel sirolimus-eluting bioresorbable scaffold for the treatment of de novo coronary artery disease: One-year results from a prospective patient-level pooled analysis of NeoVas trials.

Catheter Cardiovasc Interv 2019 Feb;93(S1):832-838

General Hospital of Northern Theater Command, Shenyang, Liaoning, China.

Objectives: This prospective, patient-level analysis assessed the safety and efficacy of NeoVas sirolimus-eluting bioresorbable scaffold (BRS) in patients with coronary lesions. Furthermore, to meet China Food and Drug Administration requirements, we conducted an objective performance criterion study by pooling all patients implanted with the NeoVas BRS in a previous randomized controlled trial (RCT) and registry trial.

Background: Drug-eluting stent-related permanent vessel caging by metallic struts may lead to several complications associated with percutaneous coronary intervention. Read More

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http://dx.doi.org/10.1002/ccd.28067DOI Listing
February 2019

Prevalence of Decreased Myocardial Blood Flow in Symptomatic Patients with Patent Coronary Stents: Insights from Low-Dose Dynamic CT Myocardial Perfusion Imaging.

Korean J Radiol 2019 Apr;20(4):621-630

Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Objective: To study the prevalence and clinical characteristics of decreased myocardial blood flow (MBF) quantified by dynamic computed tomography (CT) myocardial perfusion imaging (MPI) in symptomatic patients without in-stent restenosis.

Materials And Methods: Thirty-seven (mean age, 71.3 ± 10 years; age range, 48-88 years; 31 males, 6 females) consecutive symptomatic patients with patent coronary stents and without obstructive lesions were prospectively enrolled to undergo dynamic CT-MPI using a third-generation dual-source CT scanner. Read More

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http://dx.doi.org/10.3348/kjr.2018.0399DOI Listing

Clinical Impact of Using a More Sensitive Troponin Assay in Patients with Acute Chest Pain.

Clin Cardiol 2019 Mar 19. Epub 2019 Mar 19.

Department of Emergency, Qilu Hospital, Shandong University, Jinan, China.

Background: More sensitive troponin assays have the potential to better evaluate the patients with suspected acute coronary syndrome (ACS). Meanwhile, they may result in avoidable diagnostic testing.

Hypothesis: Our aim was to determine the clinical impact of implementing a more sensitive cardiac troponin I (cTnI) assay in patients with acute non-traumatic chest pain presenting to the emergency department (ED). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/clc.23177
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http://dx.doi.org/10.1002/clc.23177DOI Listing
March 2019
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Feasibility of planning coronary artery bypass grafting based only on coronary computed tomography angiography and CT-derived fractional flow reserve: a pilot survey of the surgeons involved in the randomized SYNTAX III Revolution trial.

Interact Cardiovasc Thorac Surg 2019 Mar 18. Epub 2019 Mar 18.

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Objectives: Invasive coronary angiography has been the preferred diagnostic method to guide the decision-making process between coronary artery bypass grafting (CABG) and percutaneous coronary intervention and plan a surgical revascularization procedure. Guidelines recommend a heart team approach and assessment of coronary artery disease (CAD) complexity, objectively quantified by the anatomical SYNTAX score. Coronary computed tomography angiography (CCTA) and CT-derived fractional flow reserve (FFRCT) are emerging technologies in the diagnosis of stable CAD. Read More

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http://dx.doi.org/10.1093/icvts/ivz046DOI Listing

Public Reporting of Percutaneous Coronary Intervention Outcomes: Institutional Costs and Physician Burden.

J Am Coll Cardiol 2019 Mar 11. Epub 2019 Mar 11.

Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Cardiovascular Division, Beth Israel Deaconess Medical and Harvard Medical School, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2019.03.014DOI Listing

Comparison of transradial and transfemoral approaches for coronary angiography and percutaneous intervention in patients with coronary bypass grafts.

Cardiovasc Revasc Med 2019 Mar 12. Epub 2019 Mar 12.

Marshall University Joan C. Edwards School of Medicine, Department of Cardiovascular Disease, United States of America.

Objective: We sought to compare the transradial and transfemoral approaches for coronary angiography and percutaneous intervention in patients with coronary artery bypass grafts in terms of volume of radiographic contrast administered during cardiac catheterization, fluoroscopy time, and total procedure time.

Background: The transradial access has been increasingly used as an alternative to transfemoral. Several studies demonstrated that such access is associated with lower rates of vascular and bleeding complications. Read More

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http://dx.doi.org/10.1016/j.carrev.2019.03.002DOI Listing

Characteristics and Outcomes in Patients With Electrical Storm.

Am J Cardiol 2019 Feb 25. Epub 2019 Feb 25.

3rd Department of Cardiology, School of Medicine with the Division of Dentistry, Zabrze, Poland; Medical University of Silesia, Katowice, Poland; Silesian Center for Heart Disease, Zabrze, Poland.

Electrical storm (ES) is a life-threatening condition with diverse clinical presentation, caused by recurrent malignant ventricular arrhythmia--≥3 episodes of ventricular tachycardia (VT) or ventricular fibrillation within 24hours and is associated with high mortality. The aim of this study was analysis of clinical profile, treatment, and prognosis of patients with ES admitted to a high-volume cardiovascular center. We present results of a single-center, retrospective, ongoing observational registry enrolling consecutive patients presenting with ES admitted between 2006 and 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149193022
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http://dx.doi.org/10.1016/j.amjcard.2019.02.021DOI Listing
February 2019
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The use of echocardiographic and clinical data recorded on admission to simplify decision making for elective percutaneous coronary intervention: a prospective cohort study.

BMC Med Inform Decis Mak 2019 Mar 18;19(1):46. Epub 2019 Mar 18.

Department of Health Management and Policy, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Background: Coronary artery disease (CAD), a leading cause of mortality, affects patient health-related quality of life (HRQoL). Elective percutaneous coronary interventions (ePCIs) are usually performed to improve HRQoL of CAD patients. The aim of this study was to design models using admission data to predict the outcomes of the ePCI treatments on the patients' HRQoL. Read More

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http://dx.doi.org/10.1186/s12911-019-0797-9DOI Listing

Adaptation and psychometric properties of the Norwegian version of the heart continuity of care questionnaire (HCCQ).

BMC Med Res Methodol 2019 Mar 18;19(1):62. Epub 2019 Mar 18.

Faculty of Health and Social Sciences, Western Norway University of Applied Sciences, Førde, Norway.

Background: Continuity of cardiac care after hospital discharge is a priority, especially as healthcare systems become increasingly complex and fragmented. There are few available instruments to measure continuity of cardiac care, especially from the patient perspective. The aim of this study was (1) to translate and adapt the Heart Continuity of Care Questionnaire (HCCQ) to conditions in Norway, and (2) to determine its psychometric properties in self-report format administered to patients after percutaneous coronary intervention (PCI). Read More

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http://dx.doi.org/10.1186/s12874-019-0706-zDOI Listing

Percutaneous Coronary Intervention following Placement of Sutureless Aortic Bioprostheses.

Innovations (Phila) 2019 Mar 18:1556984519836841. Epub 2019 Mar 18.

2 Department of Surgery, Section of Cardiothoracic Surgery, Heart and Vascular Center, University of Chicago Medicine, Chicago, IL, USA.

Coronary artery disease is often present with aortic stenosis. Although transcatheter aortic valve replacement and minimally invasive surgery provide alternative sternal-sparing options for isolated aortic valve replacement, non-sternotomy treatment of combined coronary artery disease and aortic stenosis has not been well-defined. We report 3 patients who presented with severe aortic stenosis and obstructive coronary artery disease in whom minimally invasive aortic valve replacement using sutureless valve was performed, followed by transradial percutaneous coronary intervention of obstructive coronary lesion. Read More

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http://dx.doi.org/10.1177/1556984519836841DOI Listing

Characteristics and outcomes of patients with cancer presenting with acute myocardial infarction.

Coron Artery Dis 2019 Mar 15. Epub 2019 Mar 15.

Sackler Faculty of Medicine, Tel Aviv University.

Background: Limited data are available regarding the optimal management of patients with cancer in the acute myocardial infarction (AMI) setting.

Patients And Methods: We studied consecutive patients with AMI included in a national registry (years 2010, 2016) with the diagnosis of past or active malignancy and followed them for 1 year.

Results: Our cohort consisted of 2937 cancer-naive patients and 152 patients with cancer, of whom 35% presented with active malignancies. Read More

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http://dx.doi.org/10.1097/MCA.0000000000000733DOI Listing

Coronary Angiography after Cardiac Arrest without ST-Segment Elevation.

N Engl J Med 2019 Mar 18. Epub 2019 Mar 18.

From the Departments of Cardiology (J.S.L., G.N.J., N.W.H., N.R.), Intensive Care Medicine (P.W.G.E., H.M.O.-S.), and Epidemiology and Biostatistics (P.M.V.), Amsterdam University Medical Center VUmc, the Departments of Cardiology (J.P.H.) and Intensive Care Medicine (A.P.J.V.), Amsterdam University Medical Center AMC, and the Departments of Cardiology (M.A.V.) and Intensive Care Medicine (B.B.), Onze Lieve Vrouwe Gasthuis, Amsterdam, the Thorax Center, Erasmus Medical Center (L.S.D.J., E.A.D.), and the Departments of Cardiology (G.J.V.) and Intensive Care Medicine (B.J.W.E.), Maasstad Hospital, Rotterdam, the Departments of Cardiology (M. Meuwissen) and Intensive Care Medicine (T.A.R.), Amphia Hospital, Breda, the Departments of Cardiology (H.A.B.) and Intensive Care Medicine (M.J.B.), Rijnstate Hospital, Arnhem, the Departments of Cardiology (G.B.B.) and Intensive Care Medicine (R.B.), Haga Hospital, and the Department of Cardiology, Haaglanden Medical Center (P.V.O.), The Hague, the Departments of Cardiology (P.H.) and Intensive Care Medicine (I.C.C.H.), University of Groningen, Groningen, the Departments of Cardiology (M.V.) and Intensive Care Medicine (J.J.H.), University Medical Center Utrecht, Utrecht, the Departments of Intensive Care Medicine (A.B.) and Cardiology (M.S.), Medisch Spectrum Twente, Enschede, the Departments of Cardiology (C.C., N.R.) and Intensive Care Medicine (H.H.), Radboud University Medical Center, Nijmegen, the Departments of Cardiology (T.A.C.M.H.) and Intensive Care Medicine (W.R.), Noordwest Ziekenhuisgroep, Alkmaar, the Departments of Intensive Care Medicine (T.S.R.D.) and Cardiology (H.J.G.M.C.), Maastricht University Medical Center, Maastricht, the Department of Cardiology, Scheper Hospital, Emmen (G.A.J.J.), the Department of Cardiology, Isala Hospital, Zwolle (M.T.M.G.), the Department of Cardiology, Tergooi Hospital, Blaricum (K.P.), and the Department of Cardiology, Elisabeth-Tweesteden Hospital, Tilburg (M. Magro) - all in the Netherlands.

Background: Ischemic heart disease is a major cause of out-of-hospital cardiac arrest. The role of immediate coronary angiography and percutaneous coronary intervention (PCI) in the treatment of patients who have been successfully resuscitated after cardiac arrest in the absence of ST-segment elevation myocardial infarction (STEMI) remains uncertain.

Methods: In this multicenter trial, we randomly assigned 552 patients who had cardiac arrest without signs of STEMI to undergo immediate coronary angiography or coronary angiography that was delayed until after neurologic recovery. Read More

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http://dx.doi.org/10.1056/NEJMoa1816897DOI Listing

Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation.

N Engl J Med 2019 Mar 17. Epub 2019 Mar 17.

From the Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (R.D.L., G.H., A.N.V., T.M., C.B.G., J.H.A.); Bristol-Myers Squibb, Princeton, NJ (R.A., J.L.); Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, and Cardiovascular Research Foundation, New York (R.M.); Canadian VIGOUR Centre, University of Alberta, Edmonton (S.G.G.), and the Terrence Donnelly Heart Centre, St. Michael's Hospital, University of Toronto, Toronto (S.G.G.) - both in Canada; Swiss Cardiovascular Center, Bern, Switzerland (S.W.); Vivantes Neukoelln Medical Center, Berlin (H.D.), and Heart Center Leipzig, Department of Internal Medicine-Cardiology, University of Leipzig, Leipzig (H.T.) - both in Germany; Pirogov Russian National Research Medical University, Moscow (O.A.); Instituto de Neurología Cognitiva (INECO) Neurociencias Oroño, Fundación INECO, Rosario, Argentina (M.C.B.); Hospital Israelita Albert Einstein, São Paulo (O.B.); Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.); the Department of Medical Sciences, Cardiology, and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (Z.H.); the National Scientific Center, Strazhesko Institute of Cardiology, Kiev, Ukraine (A.P.); University Hospitals Leuven, University of Leuven, Leuven, Belgium (P.S.); the Department of Infection, Immunity, and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom (R.F.S.); and University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania (D.V.).

Background: Appropriate antithrombotic regimens for patients with atrial fibrillation who have an acute coronary syndrome or have undergone percutaneous coronary intervention (PCI) are unclear.

Methods: In an international trial with a two-by-two factorial design, we randomly assigned patients with atrial fibrillation who had an acute coronary syndrome or had undergone PCI and were planning to take a P2Y inhibitor to receive apixaban or a vitamin K antagonist and to receive aspirin or matching placebo for 6 months. The primary outcome was major or clinically relevant nonmajor bleeding. Read More

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http://dx.doi.org/10.1056/NEJMoa1817083DOI Listing

Predictive value of blood urea nitrogen/creatinine ratio in the long-term prognosis of patients with acute myocardial infarction complicated with acute heart failure.

Medicine (Baltimore) 2019 Mar;98(11):e14845

Department of Cardiology, Zhongda Hospital, Nanjing, China.

At present, the long-term prognosis of patients with acute myocardial infarction (AMI) after emergency percutaneous coronary intervention is the focus of attention, and relevant research is actively investigating the risk factors associated with prognosis. Poor prognosis often exists in Patients with AMI complicated with acute heart failure (AHF). In recent years, some studies have found that blood urea nitrogen/creatinine ratio (BUN/Cr) can better predict the prognosis of patients with AHF than single BUN or Cr. Read More

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http://dx.doi.org/10.1097/MD.0000000000014845DOI Listing

Comparison of 1-year clinical outcomes between prasugrel and ticagrelor versus clopidogrel in type 2 diabetes patients with acute myocardial infarction underwent successful percutaneous coronary intervention.

Medicine (Baltimore) 2019 Mar;98(11):e14833

Division of Cardiology, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University, School of Medicine, Daejeon.

Although the new oral P2Y12 inhibitors, prasugrel/ticagrelor have shown greater efficacy than clopidogrel in patients with the acute coronary syndrome, but they have not shown better efficacy in Korean patients. So we evaluated the efficacy of the prasugrel/ticagrelor in patients with myocardial infarction (MI) and diabetes, a more high-risk patients group.From the Korea Acute Myocardial Infarction Registry-National Institute of Health, 3985 patients with MI and diabetes who underwent PCI were enrolled between November 2011 and December 2015. Read More

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http://dx.doi.org/10.1097/MD.0000000000014833DOI Listing

Relationship between fibrinogen levels and cardiovascular events in patients receiving percutaneous coronary intervention: a large single-center study.

Chin Med J (Engl) 2019 Mar 4. Epub 2019 Mar 4.

Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Centre for Coronary Heart Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

Background: It is currently unclear if fibrinogen is a risk factor for adverse events in patients receiving percutaneous coronary intervention (PCI) or merely serves as a marker of preexisting comorbidities and other causal factors. We therefore investigated the association between fibrinogen levels and 2-year all-cause mortality, and compared the additional predictive value of adding fibrinogen to a basic model including traditional risk factors in patients receiving contemporary PCI.

Methods: A total of 6293 patients undergoing PCI with measured baseline fibrinogen levels were enrolled from January to December 2013 in Fuwai Hospital. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000181DOI Listing

Prediction of Ischemic Events after Percutaneous Coronary Intervention: Thrombelastography Profiles and Factor XIIIa Activity.

TH Open 2018 Apr;2(2):e173-e181

Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana, United States.

Background: High plasma fibrin clot strength (MA) measured by thrombelastography (TEG) is associated with increased risk of cardiac events after percutaneous coronary interventions (PCIs). Factor XIIIa (FXIIIa) cross-links soluble fibrin, shortens clot formation time (TEG-K), and increases final clot strength (MA).

Methods: We analyzed platelet-poor plasma from patients with previous PCI. Read More

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http://dx.doi.org/10.1055/s-0038-1645876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419750PMC

Effect of Exercise Training on Heart Rate Variability in Patients with Heart Failure After Percutaneous Coronary Intervention.

J Biomed Phys Eng 2019 Feb 1;9(1):97-104. Epub 2019 Feb 1.

PhD of Physiotherapy, Associated professor, Physical Therapy Department, School of Rehabilitation Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: This study aims to evaluate the effect of exercise training on heart rate variability (HRV) and to determine the correlation between parameters of HRV and the ejection fraction in patients with heart failure after percutaneous coronary intervention.

Material And Methods: Fifty patients with left ventricular ejection fraction ≤ 40% undergone percutaneous coronary intervention were randomly allocated in either an exercise training (ET) group or a control group. The ET group performed exercise training for 45 minutes, three times a week for seven weeks. Read More

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February 2019

Cutting balloon angioplasty for treatment of spontaneous coronary artery dissection: case report, literature review, and recommended technical approaches.

Cardiovasc Diagn Ther 2019 Feb;9(1):50-54

Division of Cardiology, Vancouver General Hospital, University of British Columbia, Vancouver, Canada.

Conservative therapy is typically recommended for patients with spontaneous coronary artery dissection (SCAD). However, percutaneous coronary intervention (PCI) may have to be pursued in cases of ongoing ischemia or hemodynamic instability. There is early and increasing interest in using cutting balloon (CB) angioplasty to fenestrate the false lumen to allow communication and back-bleed of intramural hematoma into the true lumen. Read More

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http://dx.doi.org/10.21037/cdt.2018.10.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382663PMC
February 2019

Procedural determinants of fluoroscopy time in patients undergoing cardiac catheterization.

Pak J Med Sci 2019 Jan-Feb;35(1):166-171

Nadeem Hassan Rizvi National Institute of Cardiovascular Diseases, Karachi, Pakistan.

Background & Objective: Due to increase in number of cardiac catheterization procedures safety concerns is an issue nowadays. Multiple diagnostic modalities use radiations, which also put a patient at higher cumulative radiation exposure. Therefore steps should be taken to minimize radiation exposure during cardiac catheterization. Read More

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http://pjms.org.pk/index.php/pjms/article/view/294
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http://dx.doi.org/10.12669/pjms.35.1.294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408651PMC
March 2019
2 Reads

Clinical characteristics and long-term prognosis of spontaneous coronary artery dissection: A single-center Chinese experience.

Pak J Med Sci 2019 Jan-Feb;35(1):106-112

Xi Su, Department of Cardiology, Wuhan Asia Heart Hospital, Wuhan University of Science and Technology, Wuhan, China.

Background And Objective: Spontaneous coronary artery dissection (SCD) remains a rare and important cause of coronary artery disease (CAD). The purpose of this study was to describe the clinical and angiographic features in SCD and to evaluate the treatment and long-term prognosis of this condition in China.

Methods: This retrospective cohort study included 118 Chinese patients with SCD confirmed by coronary angiography. Read More

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http://dx.doi.org/10.12669/pjms.35.1.321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408650PMC

A Sex-Specific Analysis of the Predictive Value of Troponin I and T in Patients With and Without Diabetes Mellitus After Successful Coronary Intervention.

Front Endocrinol (Lausanne) 2019 1;10:105. Epub 2019 Mar 1.

Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Unit of Gender Medicine, Medical University of Vienna, Vienna, Austria.

Elevated levels of troponin are associated with future major adverse cardiac events (MACE). Data on the prognostic value of high sensitive troponin T (hs-TnT) compared to high sensitive troponin I (hs-TnI) in diabetic and non-diabetic patients are sparse. We analyzed patients of a single-center registry undergoing coronary stenting between 2003 and 2006. Read More

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http://dx.doi.org/10.3389/fendo.2019.00105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405417PMC

Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Treatment of Unprotected Left Main Stenosis.

Curr Cardiol Rep 2019 Mar 18;21(5):27. Epub 2019 Mar 18.

Division of Cardiology, Department of Internal Medicine, East Tennessee State University, 329 N State of Franklin Rd, Johnson City, TN, 37604, USA.

Purpose Of Review: This article reviews the latest data on unprotected left main (ULM) percutaneous coronary intervention (PCI) versus coronary artery bypass graft (CABG) surgery, with a focus on the NOBLE and EXCEL trials.

Recent Findings: In EXCEL trial, the primary endpoint at 3 years was 15.4% in the PCI group and 14. Read More

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http://dx.doi.org/10.1007/s11886-019-1113-0DOI Listing

Cardiac Surgery Trainees as "Skin-to-Skin" Operating Surgeons: Midterm Outcomes.

Ann Thorac Surg 2019 Mar 14. Epub 2019 Mar 14.

Massachusetts General Hospital, Department of Surgery, Division of Cardiothoracic Surgery, Boston, MA. Electronic address:

Background: We have previously demonstrated that cardiac surgery trainees can safely perform operations "skin-to-skin" with adequate attending surgeon supervision.

Methods: 100 consecutive cases (82 CABG, 9 AVR, 7 CABG+AVR, 2 other) performed by residents (group R) were matched 1:1 by procedure to non-consecutive cases done by a single attending surgeon (group A) from July 2014 to October 2016. Patients were stratified based on whether the attending surgeon or trainee performed every critical step of the operation "skin-to-skin". Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.02.008DOI Listing

Axillary Artery Access for Mechanical Circulatory Support Devices in Patients With Prohibitive Peripheral Arterial Disease Presenting With Cardiogenic Shock.

Am J Cardiol 2019 Feb 27. Epub 2019 Feb 27.

Wayne State University School of Medicine, Detroit Medical Center, Detroit, Michigan.

In patients with severe peripheral vascular disease, the common femoral artery may be so diseased as to not allow for deployment of mechanical circulatory support (MCS) such as in the setting of cardiogenic shock (CS). We sought to study the feasibility of axillary artery as alternative access for MCS in CS patients with severe occlusive peripheral artery disease (PAD). Records of all patients who presented with CS requiring MCS through axillary artery access from January 2016 to October 2017 were examined. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.02.033DOI Listing
February 2019

Comparison of 0.9-mm and 1.4-mm catheters in excimer laser coronary angioplasty for acute myocardial infarction.

Lasers Med Sci 2019 Mar 16. Epub 2019 Mar 16.

Department of Cardiovascular Medichine, Tokyo Medical and Dental Hospital, Tokyo, Japan.

Excimer laser coronary angioplasty (ELCA) is a unique revascularization modality that can vaporize plaque and thrombus. Compared to thrombus aspiration therapy, ELCA is reported to provide better microcirculation and reduced peripheral embolism in treatment for acute coronary syndrome. Excimer laser catheters come in various sizes, and we sought to compare the 0. Read More

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http://link.springer.com/10.1007/s10103-019-02772-x
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http://dx.doi.org/10.1007/s10103-019-02772-xDOI Listing
March 2019
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First report of a hybrid robotic beating-heart quadruple totally endoscopic coronary artery bypass: toward complete revascularization.

Eur J Cardiothorac Surg 2019 Mar 16. Epub 2019 Mar 16.

Department of Surgery, Section of Cardiac and Thoracic Surgery, University of Chicago, Chicago, IL, USA.

To the best of our knowledge, this is the first report describing robotic beating-heart quadruple all-arterial totally endoscopic coronary artery bypass combined with percutaneous coronary intervention attempting complete revascularization (residual SYNTAX score 0). A 66-year-old male with severe triple-vessel coronary artery disease underwent percutaneous coronary intervention for a sub-total occlusion of the right coronary artery as the initial component of a hybrid revascularization strategy. Subsequently, the left coronary system was revascularized via robotic beating-heart totally endoscopic coronary artery bypass with bilateral internal mammary artery grafts. Read More

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http://dx.doi.org/10.1093/ejcts/ezz076DOI Listing

Depression and Angina Among Patients Undergoing Chronic Total Occlusion Percutaneous Coronary Intervention: The OPEN-CTO Registry.

JACC Cardiovasc Interv 2019 Mar 9. Epub 2019 Mar 9.

Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts.

Objectives: This study sought to examine depression prevalence among chronic total occlusion (CTO) patients and compared symptom improvement among depressed and nondepressed patients after percutaneous coronary intervention (PCI).

Background: Depression in cardiovascular patients is common, but its prevalence among CTO patients and its association with PCI response is understudied.

Methods: Among 811 patients from the OPEN-CTO (Outcomes, Patient Health Status, and Efficiency in Chronic Total Occlusion Hybrid Procedures) registry, we evaluated change in health status between baseline and 1-year post-PCI, as measured by the Seattle Angina Questionnaire (SAQ) and the Rose Dyspnea Score. Read More

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http://dx.doi.org/10.1016/j.jcin.2018.12.029DOI Listing

Impact of Intravascular Ultrasound-Guided Percutaneous Coronary Intervention on Long-Term Clinical Outcomes in Patients Undergoing Complex Procedures.

JACC Cardiovasc Interv 2019 Mar 9. Epub 2019 Mar 9.

Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Objectives: This study sought to determine whether intravascular ultrasound (IVUS) guidance compared with angiographic guidance reduces long-term risk of cardiac death in patients undergoing complex percutaneous coronary intervention (PCI).

Background: Although IVUS is a useful tool for accurate assessment of lesion profiles and optimal stent implantation, there are limited data on long-term clinical outcomes between IVUS-guided and angiography-guided PCI for patients with complex lesions.

Methods: From March 2003 through December 2015, a total of 6,005 patients undergoing PCI for complex lesions with drug-eluting stents were enrolled from a prospective institutional registry. Read More

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http://dx.doi.org/10.1016/j.jcin.2019.01.227DOI Listing

A Heartbreaking Sadness: Does Percutaneous Coronary Intervention Breathe New Life Into the Health Status of Patients With Chronic Total Occlusion?

JACC Cardiovasc Interv 2019 Mar 9. Epub 2019 Mar 9.

Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcin.2019.02.002DOI Listing

Distal Bioresorbable Vascular Scaffold Strut Embolization Detected at Late Follow-Up: A New BVS-Related Late Complication.

JACC Cardiovasc Interv 2019 Mar 9. Epub 2019 Mar 9.

Germans Trias i Pujol University Hospital, Autonomous University of Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jcin.2019.01.226DOI Listing

Intravascular Ultrasound for Complex Percutaneous Coronary Intervention: A Far Too Complex Way to Recognition.

JACC Cardiovasc Interv 2019 Mar 9. Epub 2019 Mar 9.

Hospital Universitario Marques de Valdecilla, Servicio de Cardiología, Unidad de Cardiología Intervencionista, IDIVAL, Santander, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jcin.2019.01.236DOI Listing

Feasibility of implanting 50-60 mm-tapered drug eluting stents in chronic total occlusions.

Cardiovasc Revasc Med 2019 Feb 20. Epub 2019 Feb 20.

Cardiology Department, Hospital Clínico Universitario de Valencia, INCLIVA, Universitat de Valencia, Valencia, Spain; CIBER Cardiovascular, Spain. Electronic address:

Background: Percutaneous coronary intervention (PCI) of chronic total occlusions (CTO) usually involves multiple overlapping stents implantation to cover long coronary segments. A higher rate of restenosis has been described with stent overlapping. Recently, new long tapered stents emerged as a potential tool for treating long coronary lesions. Read More

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http://dx.doi.org/10.1016/j.carrev.2019.02.020DOI Listing
February 2019