9,123 results match your criteria Peptides [Journal]


Validation of antibody-based assays for regulatory peptides: do it once, get it right, and exploit the under-appreciated benefit of long-term antibody stability.

Authors:
Graham Dockray

Peptides 2019 Feb 13. Epub 2019 Feb 13.

Physiological Laboratory, Department of Cellular and Molecular Physiology, University of Liverpool, Crown St, Liverpool, L69 3BX, UK.. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2019.02.001DOI Listing
February 2019

Fungi-derived lipopeptide antibiotics developed since 2000.

Peptides 2019 Feb 7. Epub 2019 Feb 7.

College of Chemical Engineering and Pharmacy, Henan University of Science and Technology, Luoyang, 471023, China.

Lipopeptide antibiotics have linear or cyclic structures with one or more hydrocarbon tails linked to the N-terminus of a short oligopeptide that may be chemically modified and/or contain unusual amino acid residues in their structures. They possess huge potential as pharmaceutical drugs and biocontrol agents, and ˜30 representative genera of fungi are known to produce them. Some chemically synthesised derivatives have already been developed into commercial products or subjected to clinical trials, including cilofungin, caspofungin, micafungin, anidulafungin, rezafungin, emodepside, fusafungine and destruxins. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.02.002DOI Listing
February 2019

Orexin A modulates prolactin production by regulating BMP-4 activity in rat pituitary lactotorope cells.

Peptides 2019 Feb 2;113:35-40. Epub 2019 Feb 2.

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan. Electronic address:

The impact of orexins on anterior pituitary function has yet to be clarified. We studied the effects of orexin A and its interaction with the bone morphogenetic protein (BMP) system on the regulatory role of prolactin synthesis using rat lactotrope GH3 cells expressing BMP-4. Orexin type 1 receptor (OX1R), but not type 2 receptor (OX2R), was predominantly expressed in GH3 cells. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.01.002DOI Listing
February 2019
1 Read

The effects of both age and sex on irisin levels in paired plasma and cerebrospinal fluid in healthy humans.

Peptides 2019 Feb 1;113:41-51. Epub 2019 Feb 1.

Shanghai Institute of Geriatrics and Gerontology, Shanghai Key Laboratory of Clinical Geriatrics, Department of Geriatrics, Huadong Hospital, and Research Center of Aging and Medicine, Shanghai Medical College, Fudan University, Shanghai 200040, China. Electronic address:

Background: Adipo-myokine irisin has important effects on the metabolism and functioning of multiple tissues and organs. However, the effects of aging and sex on irisin levels in cerebrospinal fluid (CSF) and on circulation have not been comprehensively studied.

Objective: To investigate whether aging and sex can affect irisin levels in both CSF and plasma; to determine whether CSF irisin uptake involves a saturable transport mechanism. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.01.004DOI Listing
February 2019

The L cell transcriptome is unaffected by vertical sleeve gastrectomy but highly dependent upon position within the gastrointestinal tract.

Peptides 2019 Jan 17;113:22-34. Epub 2019 Jan 17.

Laboratory of Organic Chemistry, ETH Zurich, Schorenstrasse 16, 8603, Schwerzenbach, Switzerland. Electronic address:

Altered GLP-1 secretion from L cells has been implicated in the development of type 2 diabetes mellitus and its resolution following bariatric surgery. However, changes in L cell gene expression, which may form the basis for altered functionality after high fat diet (HFD) or bariatric surgery, have either not been investigated or have given conflicting results. We developed a gcg-DTR-eGFP reporter mouse to isolate ileal and colonic L cells from HFD fed insulin resistant mice and mice showing improved glucose tolerance following vertical sleeve gastrectomy (VSG). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781193000
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http://dx.doi.org/10.1016/j.peptides.2019.01.001DOI Listing
January 2019
7 Reads

Host-defense peptides AC12, DK16 and RC11 with immunomodulatory activity isolated from Hypsiboas raniceps skin secretion.

Peptides 2019 Jan 2;113:11-21. Epub 2019 Jan 2.

Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia da Universidade Católica de Brasília, Brasília, Brazil; Curso de Odontologia, Universidade Católica de Brasília, Brasília, Brazil; Programa de Pós-graduação em Ciências da Saúde, Universidade de Brasília, Brasília, Brazil. Electronic address:

Inflammation is a natural defense mechanism of the immune system; however, when unregulated, it can lead to chronic illness. Glucocorticoids are the most commonly used agents to effectively treat inflammatory conditions, including autoimmune diseases, however these substances can trigger a number of side effects. Thus, viable alternatives to the use of these drugs would be advantageous. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.12.007DOI Listing
January 2019
1 Read
2.618 Impact Factor

Differential effects of hypo- and hyperthyroidism on remodeling of contacts between neurons expressing the neuropeptide EI and tyrosine hydroxylase in hypothalamic areas of the male rat.

Peptides 2018 Dec 24;113:1-10. Epub 2018 Dec 24.

Laboratorio de Neurobiología, Instituto de Embriología e Histología (IHEM-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo (UNCuyo), 5500, Mendoza, Argentina.

The Neuropeptide EI (NEI, glutamic acid- isoleucine amide) participates in neuroendocrine function. Previously we demonstrated that NEI concentration is regulated by thyroid hormones in discrete hypothalamic areas in rats. We observed that the thyroid status affects the dopaminergic regulation of the pituitary hormones. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.12.008DOI Listing
December 2018
2 Reads

The polymyxin derivative NAB739 is synergistic with several antibiotics against polymyxin-resistant strains of Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii.

Peptides 2019 Feb 23;112:149-153. Epub 2018 Dec 23.

Northern Antibiotics Ltd, FI-02150, Espoo, Finland; Department of Bacteriology and Immunology, Helsinki University Medical School, FI-00014, Helsinki, Finland. Electronic address:

The antibiotic crisis has reinstated polymyxins, once abandoned because of their toxicity. Now, preclinical studies have revealed better tolerated and more effective derivatives of polymyxins such as NAB739. Simultaneously, polymyxin-resistant (PMR) strains such as the mcr-1 strains have received lots of justified publicity, even though they are still very rare. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.12.006DOI Listing
February 2019
8 Reads

Superoxide anions modulate the performance of apelin in the paraventricular nucleus on sympathetic activity and blood pressure in spontaneously hypertensive rats.

Peptides 2018 Dec 21. Epub 2018 Dec 21.

Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China. Electronic address:

The present study was designed to determine how apelin in paraventricular nucleus (PVN) modulates the renal sympathetic nerve activity (RSNA), arterial blood pressure (ABP), mean arterial pressure (MAP), and heart rate (HR), and whether superoxide anions regulate the performance of PVN apelin in spontaneously hypertensive rats (SHRs). Acute experiment was carried out with 13-week-old male Wistar-Kyoto rats (WKY) and SHRs under anaesthesia. RSNA, ABP, MAP and HR after PVN microinjection were measured. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.12.005DOI Listing
December 2018
1 Read

Centrally administered kisspeptin suppresses feeding via nesfatin-1 and oxytocin in male rats.

Peptides 2019 Feb 16;112:114-124. Epub 2018 Dec 16.

Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan. Electronic address:

Kisspeptin (KP), known as a hypothalamic neuropeptide, plays a critical role in the regulation of not only reproduction but also food intake. The anorectic neuropeptides, nesfatin-1 and oxytocin (OXT), are expressed in central nervous system, particulaly in various hypothalamic nuclei, and peripheral tissue. We examined the effects of the intracerebroventricular (icv) administration of KP-10 on feeding and nesfatin-1-immunoreactive (ir) or OXT-ir neurons in the rat hypothalamus, using Fos double immunohistochemistry in male rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183024
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http://dx.doi.org/10.1016/j.peptides.2018.12.003DOI Listing
February 2019
10 Reads

Exploiting endogenous opioids: Lessons learned from endomorphin 2 in the female rat.

Peptides 2019 Feb 14;112:133-138. Epub 2018 Dec 14.

Department of Neuroscience, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.

Effective management of chronic pain is demanded by ethical as well as medical considerations. Although opioid analgesics remain among the most effective pharmacotherapies for ameliorating many types of pain, their use is clouded by concerns regarding their addictive properties, underscored by the current epidemic of prescription opioid abuse and attendant deaths. Medicinal harnessing of endogenous opioid antinociception could provide a strategy for continuing to take advantage of the powerful antinociceptive properties of opioids while avoiding their abuse potential. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.12.002DOI Listing
February 2019
1 Read

Epinecidin-1: A marine fish antimicrobial peptide with therapeutic potential against Trichomonas vaginalis infection in mice.

Peptides 2019 Feb 12;112:139-148. Epub 2018 Dec 12.

Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, Kaohsiung 811, Taiwan. Electronic address:

Trichomoniasis is caused by infection with the protozoan parasite Trichomonas vaginalis, and prolonged persistence may lead to serious ill effects in patients. Thus, the development of new therapeutic strategies to combat drug-resistant T. vaginalis would be clinically beneficial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183024
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http://dx.doi.org/10.1016/j.peptides.2018.12.004DOI Listing
February 2019
12 Reads

NOP agonist action of cebranopadol counteracts its liability to promote physical dependence.

Peptides 2019 Feb 12;112:101-105. Epub 2018 Dec 12.

Department of Medical Sciences, Section of Pharmacology, and National Institute of Neuroscience, University of Ferrara, Ferrara, Italy. Electronic address:

Cebranopadol is a mixed NOP/opioid receptor agonist currently under development as innovative analgesic. In this study the liability of cebranopadol to produce opioid-type physical dependence has been evaluated in comparison with morphine in wild type mice and in mice knockout for the NOP receptor gene (NOP(-/-)). Mice were treated twice a day for 5 days with increasing doses of cebranopadol or morphine (cumulative doses 10. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183024
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http://dx.doi.org/10.1016/j.peptides.2018.12.001DOI Listing
February 2019
7 Reads

Genetic loss of proadrenomedullin N-terminal 20 peptide (PAMP) in mice is compatible with survival.

Peptides 2019 Feb 8;112:96-100. Epub 2018 Dec 8.

Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 111 Mason Farm Road, CB 7545, Chapel Hill, NC, 27599, USA. Electronic address:

Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are small peptides derived from a common precursor, pre-proadrenomedullin. Although AM and PAMP share hypotensive effects in the cardiovascular system, the peptides also exert diverse and distinct effects on endocrine physiology, innate immunity, cytoskeletal biology and receptor signaling pathways. Tremendous knowledge has been gleaned from the study of several genetic animal models of AM deletion or overexpression, some of which also simultaneously delete the coding region for PAMP peptide. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362461PMC
February 2019
9 Reads

Efficacy of lanthionine-stabilized angiotensin-(1-7) in type I and type II diabetes mouse models.

Peptides 2019 Feb 4;112:78-84. Epub 2018 Dec 4.

Constant Pharmaceuticals LLC, 398 Columbus Ave, PMB 507, Boston, MA, 02116, USA.

Native angiotensin-(1-7) exerts many therapeutic effects. However, it is rapidly degraded by ACE and other peptidases. This drawback is largely eliminated for lanthionine-stabilized angiotensin-(1-7), termed cAng-(1-7), which is fully resistant to ACE and has strongly increased resistance to other peptidases. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.10.015DOI Listing
February 2019
1 Read

Peptides combined - physiology revisited!

Peptides 2018 Dec;110:A1-A2

Institute of Biomedicine and Biocenter of Oulu, Medical Research Center and University Hospital, University of Oulu, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2018.11.001DOI Listing
December 2018
1 Read

Identification of expression and function of the glucagon-like peptide-1 receptor in colonic smooth muscle.

Peptides 2019 Feb 30;112:48-55. Epub 2018 Nov 30.

Department of Physiology and Biophysics, VCU Program in Enteric Neuromuscular Sciences, Virginia Commonwealth University, Box 980551, Richmond, VA, 23298, United States. Electronic address:

The insulinotropic effects of the incretin hormone, glucagon-like peptide-1 (GLP-1) are mediated via GLP-1 receptors (GLP-1R) present on pancreatic β cells. GLP-1 causes a decrease in the motility of stomach and intestine which involves both central and peripheral nervous systems. The expression and function of GLP-1R in gastrointestinal smooth muscle, however, are not clear. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342651PMC
February 2019
2 Reads

High doses of ANP and BNP exacerbate lipolysis in humans and the lipolytic effect of BNP is associated with cardiac triglyceride content in pigs.

Peptides 2019 Feb 30;112:43-47. Epub 2018 Nov 30.

Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Cardiorenal physiology (Mayo Clinic, Rochester, MN, USA; Copenhagen University, Denmark.

Drugs facilitating the cardioprotective effects of natriuretic peptides are introduced in heart failure treatment. ANP and BNP also stimulate lipolysis and increase circulating concentrations of free fatty acids (FFAs); an aspect, however, thought to be confined to primates. We examined the lipolytic effect of natriuretic peptide infusion in healthy young men and evaluated the effect in a porcine model of myocardial ischemia and reperfusion. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.11.003DOI Listing
February 2019
2 Reads

Antimicrobial peptide KSL-W and analogues: Promising agents to control plant diseases.

Peptides 2019 Feb 30;112:85-95. Epub 2018 Nov 30.

LIPPSO, Department of Chemistry, University of Girona, Campus Montilivi, Girona, Spain. Electronic address:

Recent strong restrictions on the use of pesticides has prompted the search for safer alternatives, being antimicrobial peptides promising candidates. Herein, with the aim of identifying new agents, 15 peptides reported as plant defense elicitors, promiscuous, multifunctional or antimicrobial were selected and tested against six plant pathogenic bacteria of economic importance. Within this set, KSL-W (KKVVFWVKFK-NH) displayed high antibacterial activity against all the tested pathogens, low hemolysis and low phytotoxicity in tobacco leaves. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183024
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http://dx.doi.org/10.1016/j.peptides.2018.11.009DOI Listing
February 2019
9 Reads

Liraglutide inhibited AGEs induced coronary smooth muscle cell phenotypic transition through inhibiting the NF-κB signal pathway.

Peptides 2019 Feb 1;112:125-132. Epub 2018 Dec 1.

Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, China.

Vascular smooth muscle cell (VSMC) phenotype transition is involved in diabetes-associated cardiovascular diseases. The mechanism of VSMCs phenotypic transition in T2DM was still unclear. Rat coronary artery SMCs were pretreated with liraglutide alone, liraglutide and H89(a PKA inhibitor), neutralizing anti-RAGE antibody or the antioxidant pyrrolidine dithiocarbamate (PDTC; a nuclear factor-κB (NF-κB) inhibitor), followed by treatment with AGE. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.11.008DOI Listing
February 2019
2 Reads

Biochemical and pharmacological investigation of novel nociceptin/OFQ analogues and N/OFQ-RYYRIK hybrid peptides.

Peptides 2019 Feb 1;112:106-113. Epub 2018 Dec 1.

Institute of Biochemistry, Biological Research Center, Hungarian Academy of Sciences, H-6726 Szeged, Temesvári krt. 62., Hungary. Electronic address:

The endogenous ligand nociceptin (N/OFQ) and a positively charged synthetic peptide RYYRIK are both selective for the nociceptin opioid receptor (NOPr). Despite their structural dissimilarity, N/OFQ and RYYRIK compete for the same binding site of NOP receptor possessing full and partial agonistic character, respectively. In the view of the message-address concept, hybrid peptide constructs were probed for the NOP receptor combining different regions of N/OFQ and RYYRIK related peptide sequences. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183024
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http://dx.doi.org/10.1016/j.peptides.2018.11.010DOI Listing
February 2019
2 Reads

The effect of halogenation on the antimicrobial activity, antibiofilm activity, cytotoxicity and proteolytic stability of the antimicrobial peptide Jelleine-I.

Peptides 2019 Feb 27;112:56-66. Epub 2018 Nov 27.

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, School of Life Sciences, Lanzhou University, 222 Tian Shui South Road, Lanzhou, 730000, PR China. Electronic address:

Antimicrobial peptides (AMPs) are believed to be a promising class of antimicrobial agents against bacteria and fungi. To promote the clinical use of AMPs, their antimicrobial activity and susceptibility to protease degradation should be further improved. The antimicrobial peptide Jelleine-I was originally isolated from the royal jelly of honeybees (Apis mellifera) with a short sequence of PFKLSLHL-NH (953. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.11.006DOI Listing
February 2019
4 Reads
2.618 Impact Factor

Active-site directed peptide l-Phe-d-His-l-Leu inhibits angiotensin converting enzyme activity and dexamethasone-induced hypertension in rats.

Peptides 2019 Feb 24;112:34-42. Epub 2018 Nov 24.

Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, 570 006, India. Electronic address:

Hypertension is the fundamental cause of cardiovascular and cerebrovascular disorders. Several natural and synthetic peptides are being used as antihypertensive agents, which target angiotensin converting enzyme (ACE), the master regulator of angiotensin (Ang) II production. In this study, we have evaluated ACE-inhibitory potential of the tripeptide l-Phenylalanyl-d-Histidyl-l-Leucine (l-Phe-d-His-l-Leu) in vitro and its antihypertensive effect in rat model of dexamethasone-induced hypertension. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.11.002DOI Listing
February 2019
3 Reads

Towards establishing a higher acceptance rate for PEPTIDES - The peer review process and criteria for acceptance or rejection.

Peptides 2019 Feb 24;112:32-33. Epub 2018 Nov 24.

Institute of Biomedicine and Biocenter of Oulu, Oulu University, Finland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183023
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http://dx.doi.org/10.1016/j.peptides.2018.11.004DOI Listing
February 2019
6 Reads

Inhibition of peptide BF-30 on influenza A virus infection in vitro/vivo by causing virion membrane fusion.

Peptides 2019 Feb 14;112:14-22. Epub 2018 Nov 14.

School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, 210009, PR China. Electronic address:

Influenza A virus is a leading cause of mortality in humans and poses a global health emergency due to its newly adapted and resistant strains. Thus, there is an urgency to develop novel anti-influenza drugs. Peptides are a type of biological molecule having a wide range of inhibitory effects against bacteria, fungi, viruses and cancer cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183018
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http://dx.doi.org/10.1016/j.peptides.2018.10.004DOI Listing
February 2019
11 Reads

The effects of the urocortins on the hypothalamic-pituitary-adrenal axis - similarities and discordancies between rats and mice.

Peptides 2019 Feb 8;112:1-13. Epub 2018 Nov 8.

Department of Pathophysiology, Faculty of Medicine, University of Szeged, Hungary.

The urocortins (Ucn I, Ucn II and Ucn III) are structural analogues of corticotropin-releasing factor (CRF). The aim of our present experiments was to compare the effects of the urocortins on the hypothalamic-pituitary-adrenal (HPA) axis in rats and mice, including the hypothalamic adrenocorticotropic hormone (ACTH) secretagogues, such as CRF and arginine vasopressin (AVP). Therefore, male CFLP mice and male Wistar rats were injected intracerebroventricularly (icv) with 0. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.10.014DOI Listing
February 2019
2 Reads

Cocaine- and amphetamine-regulated transcript (CART): A multifaceted neuropeptide.

Peptides 2018 Dec 1;110:56-77. Epub 2018 Nov 1.

Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Institute, Tehran University of Medical Science, Tehran, Iran. Electronic address:

Over the last 35 years, the continuous discovery of novel neuropeptides has been the key to the better understanding of how the central nervous system has integrated with neuronal signals and behavioral responses. Cocaine and amphetamine-regulated transcript (CART) was discovered in 1995 in the rat striatum but later was found to be highly expressed in the hypothalamus. The widespread distribution of CART peptide in the brain complicated the understanding of the role played by this neurotransmitter. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.10.008DOI Listing
December 2018
11 Reads

Determinants of opioid abuse potential: Insights using intracranial self-stimulation.

Peptides 2019 Feb 1;112:23-31. Epub 2018 Nov 1.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond VA 23298, United States.

Intracranial self-stimulation (ICSS) is one procedure that can be used for preclinical abuse potential assessment. In ICSS procedures, subjects with microelectrodes implanted into a brain-reward region are trained to press an operant response lever for pulses of electrical brain stimulation, and drugs are evaluated for their effectiveness to increase or "facilitate" ICSS responding (an abuse-related effect) or to depress ICSS responding (an abuse-limiting effect). ICSS has been used for decades to evaluate determinants of opioid abuse potential, and this article reviews pharmacological and biological determinants of opioid abuse potential as revealed by ICSS studies in rodents. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183019
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http://dx.doi.org/10.1016/j.peptides.2018.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342636PMC
February 2019
27 Reads

The role of CNP-mediated PKG/PKA-PLCβ pathway in diabetes-induced gastric motility disorder.

Peptides 2018 Dec 1;110:47-55. Epub 2018 Nov 1.

Department of Physiology, Yanbian University School of Medicine, 977 Gongyuan, Road, Jilin, Yanji 133002, China. Electronic address:

Our previous work demonstrated that the C-type natriuretic peptide (CNP)/cyclic guanosine monophosphate (cGMP)/cyclic adenosine monophosphate (cAMP) pathway in gastric antrum smooth muscle of rats with diabetes was upregulated and played an important role in the development of diabetic gastric dysmotility. Our goal for this study was to explore the downstream signaling pathways of CNP. We found that the expressions of protein kinase G (PKG) and protein kinase A (PKA) in gastric smooth muscle tissue of rats with diabetes were significantly upregulated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183019
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http://dx.doi.org/10.1016/j.peptides.2018.10.012DOI Listing
December 2018
13 Reads

Analgesic activities of the mixed opioid and NPFF receptors agonist DN-9 in a mouse model of formalin-induced orofacial inflammatory pain.

Peptides 2018 Dec 1;110:30-39. Epub 2018 Nov 1.

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, China. Electronic address:

Orofacial pain is one of the most common pain conditions and compromises the quality of life of the sufferer. Several studies have shown that opioid agonists produced significant analgesia in the orofacial pain, and combination of opioids with drugs belonging to other classes induced synergism in the orofacial pain. However, combination therapy of different analgesic drugs improves the risk of drug-drug interactions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183019
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http://dx.doi.org/10.1016/j.peptides.2018.10.010DOI Listing
December 2018
6 Reads

Glucagon-related peptides from phylogenetically ancient fish reveal new approaches to the development of dual GCGR and GLP1R agonists for type 2 diabetes therapy.

Peptides 2018 Dec 1;110:19-29. Epub 2018 Nov 1.

Diabetes Research Group, School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, Northern Ireland, BT52 1SA, UK.

The insulinotropic and antihyperglycaemic properties of glucagons from the sea lamprey (Petromyzontiformes), paddlefish (Acipenseriformes) and trout (Teleostei) and oxyntomodulin from dogfish (Elasmobranchii) and ratfish (Holocephali) were compared with those of human glucagon and GLP-1 in mammalian test systems. All fish peptides produced concentration-dependent stimulation of insulin release from BRIN-BD11 rat and 1.1 B4 human clonal β-cells and isolated mouse islets. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183019
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http://dx.doi.org/10.1016/j.peptides.2018.10.013DOI Listing
December 2018
13 Reads

Intra-hippocampal administration of orexin receptor antagonists dose-dependently attenuates reinstatement of morphine seeking behavior in extinguished rats.

Peptides 2018 Dec 1;110:40-46. Epub 2018 Nov 1.

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

It has been shown that the hippocampus plays an essential role in the regulation of reward and memory as indicated by the conditioned place preference (CPP) paradigm. Morphine-induced CPP is a common method to consider motivational properties of morphine in animals. Recently, this model has been used in many laboratories to investigate neuronal mechanisms underlying reinstatement of morphine seeking induced by drug re-exposure. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.10.011DOI Listing
December 2018
2 Reads

Expression of neuropeptide Y and gonadotropin-releasing hormone gene types in the brain of female Nile tilapia (Oreochromis niloticus) during mouthbrooding and food restriction.

Peptides 2019 Feb 30;112:67-77. Epub 2018 Oct 30.

Brain Research Institute, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia.

A cichlid fish, the Nile tilapia (Oreochromis niloticus), is a maternal mouthbrooder, which exhibits minimum energy expenditure and slower ovarian cycles during mouthbrooding. The objective of this study was to observe changes in the gene expression of key neuropeptides involved in the control of appetite and reproduction, including neuropeptide Y a (NPYa), reproductive neuropeptides: gonadotropin-releasing hormone (GnRH1, GnRH2 and GnRH3) and kisspeptin (Kiss2) during mouthbrooding (4- and 12-days), 12-days of food restriction and 12-days of food restriction followed by refeeding. The food restriction regime showed a significant increase in npya mRNA levels in the telencephalon. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.10.009DOI Listing
February 2019
1 Read

RAMP3 deficiency enhances postmenopausal obesity and metabolic disorders.

Peptides 2018 Dec 29;110:10-18. Epub 2018 Oct 29.

Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Japan.

There is a marked increase in the incidence of visceral adiposity and insulin resistance among women following menopause. Adrenomedullin (AM) is an endogenous peptide first identified as a vasodilator, but now known to exert a variety of physiological effects. RAMP3 is a receptor activity-modifying protein that binds to the AM receptor (calcitonin receptor-like receptor). Read More

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http://dx.doi.org/10.1016/j.peptides.2018.10.006DOI Listing
December 2018
2 Reads

BJ-PRO-7A and BJ-PRO-10C induce vasodilatation and inotropic effects in normotensive and hypertensive rats: Role of nitric oxide and muscarinic receptors.

Peptides 2018 Dec 21;110:1-9. Epub 2018 Oct 21.

Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, 74690-900, Brazil. Electronic address:

Bj-PRO-7a and Bj-PRO-10c belong to a family of proline-rich oligopeptides (PROs) identified in Bothrops jararaca (Bj) crude venom. Previous studies have shown an antihypertensive effect evoked by theses peptides. However, the mechanisms underlying the direct effects on vessels and heart remain to be unraveled. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.10.005DOI Listing
December 2018
11 Reads

Endothelin and the heart in health and diseases.

Peptides 2019 Jan 21;111:77-88. Epub 2018 Oct 21.

Department of Cardiology, Faculty of Medicine, University of Tsukuba, Japan.

Endothelin-1 (ET-1), a 21-amino acid peptide, was initially identified in 1988 as a potent vasoconstrictor and pressor substance isolated from the culture supernatant of porcine aortic endothelial cells. From human genomic DNA analysis, two other family peptides, ET-2 and ET-3, were found. They showed different effects and distribution, suggesting that each peptide may play separate roles in different organs. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.10.002DOI Listing
January 2019
13 Reads

Understanding the functions of kisspeptin and kisspeptin receptor (Kiss1R) from clinical case studies.

Peptides 2018 Oct 16. Epub 2018 Oct 16.

Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau, China. Electronic address:

It is widely acknowledged that kisspeptin and its receptor Kiss1R play central regulatory roles in the hypothalamus-pituitary-gonad (HPG) axis and reproduction. Mutations of KISS1 and KISS1R lead to disorders associated with pubertal development, such as central precocious puberty (CPP) and idiopathic hypogonadotropic hypogonadism (IHH). This review focuses on KISS1 and KISS1R mutations found in CPP and IHH and its purposes are twofold: Firstly, based on the mutations found in KISS1 and KISS1R, this review provides insights into the precise mechanism of kisspeptin and the kisspeptin/Kiss1R pathway in the reproductive axis and in puberty. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.09.007DOI Listing
October 2018
3 Reads

Heart peptides: Physiology and pathophysiology.

Peptides 2019 Jan 10;111:1-2. Epub 2018 Oct 10.

Institute of Biomedicine & Biocenter of Oulu, University of Oulu, Medical Research Center and University Hospital, University of Oulu, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2018.10.003DOI Listing
January 2019
3 Reads

The host defense peptide LL-37 triggers release of nucleic acids from human mast cells.

Peptides 2018 Nov 9;109:39-45. Epub 2018 Oct 9.

Department of Experimental Medical Science, Lund University, Lund, Sweden. Electronic address:

The human host defense peptide LL-37 possesses antimicrobial activity but also affects host cell function and viability. Mast cells are involved in innate immunity but no data have been presented on effects of LL-37 on human mast cell viability and export of nucleic acids. Here, we demonstrated by immunofluorescence microscopy that synthesized LL-37 was internalized by human LAD2 mast cells and detected both in cytoplasm and nucleus. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.10.001DOI Listing
November 2018
2 Reads

PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner.

Peptides 2018 Sep 28. Epub 2018 Sep 28.

National Institute of Diabetes, Digestive and Kidney Disease, Digestive Diseases Branch, 9000 Rockville Pike, Bethesda, MD, 20892, USA.

Pituitary adenylate cyclase activating polypeptide (PACAP) is a growth factor for lung cancer cells. PACAP-27 or PACAP-38 binds with high affinity to non-small cell lung cancer (NSCLC) cells, causing elevated cytosolic Ca, increased proliferation and increased phosphorylation of extracellular regulated kinase (ERK) and the epidermal growth factor receptor (EGFR). The role of reactive oxygen species (ROS) was investigated in these processes. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.09.005DOI Listing
September 2018
7 Reads

Resistin levels are not associated with obesity in central precocious puberty.

Peptides 2018 Nov 29;109:9-13. Epub 2018 Sep 29.

Unit of Medical Research in Clinical Epidemiology, National Medical Center XXI Century, Instituto Mexicano del Seguro Social, Mexico City, Mexico. Electronic address:

Objective: To compare serum resistin concentrations between prepubertal girls with a BMI > 85th percentile and girls with precocious puberty (CPP) who have and have not undergone GnRH analog treatment.

Patients And Methods: This is a cross-sectional study in girls with a BMI > 85th percentile and a median age of 8 years. We included 31 girls with CPP who did not receive treatment (CPPoT), 23 girls with CPP who were treated with leuprolide (CPPT), 22 prepubertal girls and 24 pubertal girls. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.09.009DOI Listing
November 2018
9 Reads

Elabela, a newly discovered APJ ligand: Similarities and differences with Apelin.

Peptides 2018 Nov 26;109:23-32. Epub 2018 Sep 26.

Department of Nephrology, Second Hospital of Jilin University, Changchun 130041, China. Electronic address:

The Apelin/APJ system is involved in a wide range of biological functions. For a long time, Apelin was thought to be the only ligand for APJ. Recently, a new peptide that acts via APJ and has similar functions, called Elabela, was identified. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.09.006DOI Listing
November 2018
11 Reads

The oxytocin system of mice and men-Similarities and discrepancies of oxytocinergic modulation in rodents and primates.

Peptides 2018 Nov 24;109:1-8. Epub 2018 Sep 24.

Schaller Research Group on Neuropeptides at German Cancer Research Center (DKFZ) and Cell Network Cluster of Excellence at the University of Heidelberg, Heidelberg, Germany; Central Institute of Mental Health (ZI), Mannheim, Germany.

Nonapeptides and their respective receptors have been conserved throughout evolution and display astonishing similarities among the animal kingdom. They can be found in worms, birds, fish, amphibians, reptiles and mammals, including rodents, non-human primates and humans. In particular, the neuropeptide oxytocin (OT) has attracted the attention of scientists due to its profound effects on social behavior. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.09.003DOI Listing
November 2018
4 Reads

Intraperitoneal injection of nesfatin-1 primarily through the CCK-CCK1R signal pathway affects expression of appetite factors to inhibit the food intake of Siberian sturgeon (Acipenser baerii).

Peptides 2018 Nov 24;109:14-22. Epub 2018 Sep 24.

Department of Aquaculture, College of Animal Science and Technology, Sichuan Agricultural University, 211# Huimin Road, Chengdu, Sichuan, China. Electronic address:

Nesfatin-1 is an 82-amino acid protein derived from nucleobindin 2 (NUCB2), which could inhibit food intake in fish and mammals. However, the neuroendocrine mechanism of nesfatin-1 in animal appetite regulation is unclear. To explore the feeding mechanism of nesfatin-1 in Siberian sturgeon (Acipenser baerii), intraperitoneal injections of nesfatin-1 and sulfated cholecystokinin octapeptide (CCK8), Lorglumide (CCK1R selective antagonist), or LY 225,910 (CCK2R selective antagonist) were performed. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.09.008DOI Listing
November 2018
21 Reads

The antimicrobial peptides casocidins I and II: Solution structural studies in water and different membrane-mimetic environments.

Peptides 2018 Sep 19. Epub 2018 Sep 19.

Institute of Biostructures and Bioimaging (IBB), National Research Council & Interuniversity Research Centre on Bioactive Peptides (CIRPEB), Via Mezzocannone 16, 80134 Naples, Italy. Electronic address:

Antimicrobial peptides (AMPs) represent crucial components of the natural immune defense machinery of different organisms. Generally, they are short and positively charged, and bind to and destabilize bacterial cytoplasmic membranes, ultimately leading to cell death. Natural proteolytic cleavage of α-casein in bovine milk generates the antimicrobial peptides casocidin I and II. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.09.004DOI Listing
September 2018
2 Reads

Glucagon-like peptide-1 receptor action in the vasculature.

Peptides 2019 Jan 15;111:26-32. Epub 2018 Sep 15.

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada. Electronic address:

Glucagon-like peptide-1 receptor (GLP-1R) agonists augment insulin secretion and are thus used clinically to improve glycemia in subjects with type 2 diabetes (T2D). As recent data reveal marked improvements in cardiovascular outcomes in T2D subjects treated with the GLP-1R agonists liraglutide and semaglutide in the LEADER and SUSTAIN-6 clinical trials respectively, there is growing interest in delineating the mechanism(s) of action for GLP-1R agonist-induced cardioprotection. Of importance, negligible GLP-1R expression in ventricular cardiac myocytes suggests that cardiac-independent actions of GLP-1R agonists may account for the reduced death rates from cardiovascular causes in T2D subjects enrolled in the LEADER trial. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.09.002DOI Listing
January 2019
5 Reads

Ghrelin attenuates myocardial fibrosis after acute myocardial infarction via inhibiting endothelial-to mesenchymal transition in rat model.

Peptides 2019 Jan 12;111:118-126. Epub 2018 Sep 12.

Research Lab for Clinical & Translational Medicine, Medical school, University of South China, Hengyang 421001, China; Institute of Cardiovascular Research, Key Laboratory Atherosclerology of Hunan Province, University of South China, Hengyang 421001, China. Electronic address:

Ghrelin, a peptide hormone produced in the gastrointestinal tract, has recently been found to be associated with the onset of myocardial fibrosis (MF). The exact mechanism, however, remains elusive. This study sought to identify the function and mechanism of ghrelin on MF after acute myocardial infarction (AMI). Read More

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http://dx.doi.org/10.1016/j.peptides.2018.09.001DOI Listing
January 2019
4 Reads

Validation of antibody-based tools for galanin research.

Peptides 2018 Sep 6. Epub 2018 Sep 6.

Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, University Hospital of the Paracelsus Medical University, Muellner Hauptstraße 48, 5020, Salzburg, Austria. Electronic address:

Antibodies are an integral biomedical tool, not only for research but also as therapeutic agents. However, progress can only be made with sensitive and specific antibodies. The regulatory (neuro)peptide galanin and its three endogenous receptors (GAL-R) are widely distributed in the central and peripheral nervous systems, and in peripheral non-neuronal tissues. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.08.010DOI Listing
September 2018
15 Reads

Novel peptide inhibitor of dipeptidyl peptidase IV (Tyr-Pro-D-Ala-NH) with anti-inflammatory activity in the mouse models of colitis.

Peptides 2018 Oct 1;108:34-45. Epub 2018 Sep 1.

Department of Biochemistry, Department of Pathology, Faculty of Medicine, Medical University of Lodz, Lodz, Poland. Electronic address:

Protease inhibition has become a new possible approach in the inflammatory bowel disease (IBD) therapy. A serine exopeptidase, dipeptidyl peptidase IV (DPP IV) is responsible for inactivation of incretin hormone, glucagon-like peptide 2 (GLP-2), a potent stimulator of intestinal epithelium regeneration and growth. Recently we showed that the novel peptide analog of endomorphin-2, EMDB-1 (Tyr-Pro-D-ClPhe-Phe-NH) is a potent blocker of DPP IV and exhibits an anti-inflammatory activity in vivo. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.08.011DOI Listing
October 2018
3 Reads

Effects of angiotensin-(1-7) and angiotensin II on vascular tone in human cirrhotic splanchnic vessels.

Peptides 2018 Oct 1;108:25-33. Epub 2018 Sep 1.

Liver Unit, Austin Health, Melbourne, Australia; Department of Medicine, Austin Health, University of Melbourne, Australia.

Evidence suggests that the renin angiotensin system (RAS) may play a role in the pathological splanchnic vasodilatation that leads to a hyperdynamic circulation in cirrhosis. An impaired contractile response to the angiotensin II peptide of the classical RAS system has been described in animal models of cirrhosis and in vivo in cirrhotic subjects. Furthermore, in experimental cirrhosis, the so-called alternate arm of the RAS was found to be upregulated and its effector peptide, angiotensin-(1-7) was shown to attenuate splanchnic vascular tone. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.08.008DOI Listing
October 2018
4 Reads