9,143 results match your criteria Peptides [Journal]


Osteopontin-derived synthetic peptide SVVYGLR has potent utility in the functional regeneration of oral and maxillofacial skeletal muscles.

Peptides 2019 Apr 17. Epub 2019 Apr 17.

The 1st Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, 1-8 Yamada-oka, Suita, Osaka, 565-0871, Japan. Electronic address:

Oral and maxillofacial skeletal muscles are critical for oral motor functions, and severe damage to these muscles by trauma or surgery may lead to persistent functional impairment. This study investigated the effects of SVVYGLR (SV) peptide, a thrombin-cleaved osteopontin-derived motif, on histopathological wound healing and functional repair after severe injury of skeletal muscles. A rat model of volumetric muscle loss bilateral masseter muscle was developed. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.04.013DOI Listing

BZ043, a novel long-acting amylin analog, reduces gastric emptying, food intake, glycemia and insulin requirement in streptozotocin-induced diabetic rats.

Peptides 2019 Apr 14. Epub 2019 Apr 14.

National Institute of Science and Technology for Structural Biology and Bioimaging (INBEB-INCT), Federal University of Rio de Janeiro, Rio de Janeiro 21941-590, Brazil. Electronic address:

Amylin analogs are important adjunctive drugs in the treatment of diabetes mellitus. However, a dual therapy with insulin involves inconvenient multiple injections. Here we describe a novel n-terminal PEGylated human amylin analog - BZ043 - and its potential to improve the control of glycemia using lower doses of insulin. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.04.004DOI Listing

Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates renal (pro)renin receptor expression in Npr1 null mutant mice.

Peptides 2019 Apr 6. Epub 2019 Apr 6.

Department of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA, 70112, United States. Electronic address:

The objective of the present study was to determine whether targeted-disruption of Npr1 gene (encoding for guanylyl cyclase/natriuretic peptide receptor-A; GC-A/NPRA) upregulates pro(renin) receptor (P)RR expression and leads to the activation of MAPKs in Npr1 gene-knockout mice. The Npr1 homozygous (Npr1; 0-copy), heterozygous (Npr1; 1-copy), wild-type (Npr1; 2-copy), and gene-duplicated (Npr1; 4-copy) mice were utilized. To identify the canonical pathway of (P)RR, we administered ACE-1 inhibitor (captopril), AT1R blocker (losartan), and MAPKs inhibitors (U0126 and SB203580) to all Npr1 mice genotypes. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.03.001DOI Listing

Nesfatin-1: A novel regulatory peptide associated with acute myocardial infarction and Mediterranean diet.

Peptides 2019 Apr 5. Epub 2019 Apr 5.

Hacettepe University Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkey. Electronic address:

We evaluated the relationship between nesfatin-1 and acute myocardial infarction (AMI) and Mediterranean diet scores. 67 patients with AMI and 33 patients with normal coronary arteries (control group) were included in the study. The patients with AMI were divided into 2 groups based on low (<32) (n = 33) and high values of the synergy between percutaneous coronary intervention with Taxus and cardiac surgery (SYNTAX) scores (≥34) (n = 35). Read More

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http://dx.doi.org/10.1016/j.peptides.2019.04.003DOI Listing
April 2019
1 Read

Elabela protects against podocyte injury in mice with streptozocin-induced diabetes by associating with the PI3K/Akt/mTOR pathway.

Peptides 2019 Apr 5. Epub 2019 Apr 5.

Department of Nephrology, Second Hospital of Jilin University, Changchun 130041, China. Electronic address:

Diabetic nephropathy is a common complication of diabetes characterized by an increased rate of protein excretion in urine and kidney function loss. Elabela is a newly discovered peptide whose role in the regulation of diabetes is the major focus of this research. We established an in vivo model of Type 1 diabetes mellitus by injecting mice intraperitoneally with streptozotocin. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.04.005DOI Listing
April 2019
2 Reads

Peptide Conjugates Of Lactoferricin Analogues And Antimicrobials - Design, Chemical Synthesis, And Evaluation Of Antimicrobial Activity And Mammalian Cytotoxicity.

Peptides 2019 Apr 5. Epub 2019 Apr 5.

Department of Molecular Biochemistry, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.

Eight new peptide conjugates composed of modified bovine lactoferricin truncated analogues (LFcinB) and one of the three antimicrobials - ciprofloxacin (CIP), levofloxacin (LVX), and fluconazole (FLC) - were synthesized. Four different linkers were applied to connect a peptide and an antimicrobial agent. The FLC-containing peptidic conjugates were synthesized using the "click chemistry" method. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.04.006DOI Listing
April 2019
1 Read

The effect of apelin-13 on pancreatic islet beta cell mass and myocardial fatty acid and glucose metabolism of experimental type 2 diabetic rats.

Peptides 2019 Apr 4;114:1-7. Epub 2019 Apr 4.

Department of Geratology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China. Electronic address:

Apelin, a new identified adipokine, and its G protein-coupled receptor named APJ are widely expressed in various tissues. Apelin has been found to play important roles in the physiopathology of multiple diseases. Our aim is to assess the effect of long-term apelin treatment on serum insulin level and pancreatic islet beta-cell mass in the late stage of type 2 diabetes without hyperinsulinemia and to investigate the role of apelin in myocardial fatty acid and glucose metabolism. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.03.006DOI Listing
April 2019
1 Read

The influence of high fat diet on plasma incretins and insulin concentrations in Sprague-Dawley rats with diet-induced obesity and glucose intolerance undergoing ileal transposition.

Peptides 2019 Apr 4;115:75-84. Epub 2019 Apr 4.

Department of Physiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.

Background: The benefits of IT surgery are based on incretin effects. In this study we show the influence of high fat diet (HFD) used both before and after surgery, on ileal transposition (IT) effects.

Methods: Forty-eight male rats were assigned to two groups: HFD and control diet (CD) fed rats. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.04.001DOI Listing
April 2019
1 Read

The role of phoenixin in behavior and food intake.

Peptides 2019 Apr 3. Epub 2019 Apr 3.

Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, Tübingen, Germany. Electronic address:

The recently discovered peptide phoenixin was initially implicated in reproduction as a regulator of gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone (LH) release from the pituitary. Subsequently, various functions of phoenixin have been demonstrated including mediation of itching sensation, stimulation of vasopressin secretion, stimulation of white adipogenesis and hypothalamic nutrient sensing. Subsequently, additional actions of phoenixin have been described, namely effects on behavior. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.04.002DOI Listing
April 2019
2 Reads

Neurokinin-1 receptor antagonist decreases [Ca]i in airway smooth muscle cells by reducing the reverse-mode Na/Ca exchanger current.

Peptides 2019 Apr 1;115:69-74. Epub 2019 Apr 1.

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang 110004, China.

Airway smooth muscle (ASM) is involved in asthma airway inflammation. The aim of this study was to evaluate the effect of substance P and neurokinin-1 receptor (NK-1R) antagonist on intracellular calcium concentration ([Ca]i) in airway smooth muscle cells (ASMCs), ASMC contraction, and the effect on reverse-mode Na-Ca exchanger (NCX) currents in ASMCs. In our study, primary rat ASMCs were cultured. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.03.004DOI Listing

The discovery of shorter synthetic proteolytic peptides derived from Tob1 protein.

Peptides 2019 Mar 28. Epub 2019 Mar 28.

O-Force Co. Ltd., 3454 Irino, Kuroshio-cho, Hata-gun, Kochi, 789-1931, Japan; Department of Pharmacology, Kochi Medical School, Kochi University, Kohasu Oko-cho, Nankoku, Kochi, 783-8505, Japan; Laboratory of Clinical Analytical Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.

We screened nearly 1000 synthetic peptides and found that JAL-AK22 (KYEGHWYPEKPYKGSGFRCIHI), which is derived from the BoxA domain in the Tob1 protein, activates both unfolded and folded proMMP-7. Interestingly, the smaller derivative of JAL-AK22, termed JAL-TA9 (YKGSGFRMI) possessed auto-proteolytic activity and cleaved three synthetic peptides fragment (MMP18-33, MMP18-40, and Aβ11-29) under physiological conditions. The k of JAL-TA9 was 4. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781193003
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http://dx.doi.org/10.1016/j.peptides.2019.03.005DOI Listing
March 2019
3 Reads

Satellite symposium of to the 13th international symposium on VIP, PACAP and related peptides in Macau.

Authors:
Leo Tsz On Lee

Peptides 2019 Mar 19. Epub 2019 Mar 19.

Centre of Reproduction Development and Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau, China. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2019.03.003DOI Listing

Inflammatory mediators of opioid tolerance: Implications for dependency and addiction.

Peptides 2019 Mar 16;115:51-58. Epub 2019 Mar 16.

Neuroscience Institute, Georgia State University, Atlanta, GA, 30308, United States. Electronic address:

Each year, over 50 million Americans suffer from persistent pain, including debilitating headaches, joint pain, and severe back pain. Although morphine is amongst the most effective analgesics available for the management of severe pain, prolonged morphine treatment results in decreased analgesic efficacy (i.e. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.01.003DOI Listing

Behavioral effects evoked by the beta globin-derived nonapeptide LVV-H6.

Peptides 2019 Mar 16;115:59-68. Epub 2019 Mar 16.

Department of Physiological Sciences, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, Brazil. Electronic address:

LVV-hemorphin-6 (LVV-h6) is bioactive peptide and is a product of the degradation of hemoglobin. Since LVV-h6 effects are possibly mediated by opioid or AT4/IRAP receptors, we hypothesized that LVV-h6 would modify behavior. We evaluated whether LVV-h6 affects: i) anxiety-like behavior and locomotion; ii) depression-like behavior; iii) cardiovascular and neuroendocrine reactivity to emotional stress. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.03.002DOI Listing
March 2019
3 Reads

Peptides with therapeutic potential in the venom of the scorpion Buthus martensii Karsch.

Peptides 2019 Mar 8;115:43-50. Epub 2019 Mar 8.

Medical College, Henan University of Science and Technology, Luoyang, 471003, China.

The scorpion Buthus martensii Karsch (BmK) has generated significant interest due to the presence of biologically active peptides in its venom. In the past decade, dozens of different peptides from BmK have been identified. Most of the peptides are neurotoxins and are responsible for the toxicity of BmK venom. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.02.009DOI Listing
March 2019
1 Read

Enkephalin related peptides are released from jejunum wall by orally ingested bromelain.

Peptides 2019 Mar 2;115:32-42. Epub 2019 Mar 2.

Departamento de Biofísica, Escola Paulista de Medicina, Universidade Federal de São Paulo. Rua Três de Maio, 100 - Vila Clementino. CEP, 04044-020, São Paulo, SP, Brazil; Departamento de Patologia e Clínica Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul. Av. Bento Goncalves 9500 CP15005. CEP, 91501970, Porto Alegre, RS, Brazil; CEBRID, Centro Brasileiro de Informações sobre Drogas Psicotrópicas, Departamento de Medicina Preventiva, Escola Paulista de Medicina, Universidade Federal de São Paulo. Rua Botucatu, 820 - Vila Clementino. CEP, 04024-002, São Paulo, SP, Brazil. Electronic address:

Stem bromelain [EC 3.4.22. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.02.008DOI Listing

Possible application of trefoil factor family peptides in gastroesophageal reflux and Barrett's esophagus.

Peptides 2019 Mar 1;115:27-31. Epub 2019 Mar 1.

Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland. Electronic address:

Gastroesophageal reflux disease (GERD) is a chronic disorder of the digestive tract characterised mainly by a heartburn. Being one of the most common gastrointestinal diseases, the prevalence of GERD reaches up to 25.9% in Europe. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.02.007DOI Listing
March 2019
1 Read

Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress.

Peptides 2019 Feb 16;115:8-14. Epub 2019 Feb 16.

Department of Medicine, Amager and Hvidovre Hospital in Glostrup, University of Copenhagen, Glostrup, Denmark; Department of Medicine O, Endocrine Unit, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark.

In middle-aged and elderly individuals, circulating copeptin concentrations, a surrogate marker for arginine vasopressin (AVP) secretion, associates with insulin resistance (IR). Whether this association is present in adolescents and young adults is unclear. Because psychological stress associates with higher circulating copeptin concentrations and IR, it has been speculated that increased AVP secretion could be a link between psychological stress and IR. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.02.005DOI Listing
February 2019

Antiaflatoxigenic effects of selected antifungal peptides.

Peptides 2019 Feb 15;115:15-26. Epub 2019 Feb 15.

Department of Biochemistry, University College of Science, Osmania University, Hyderabad-500 007, Telangana State, India. Electronic address:

Aflatoxins are potent carcinogenic mycotoxins produced as secondary metabolites mainly by the fungi Aspergillus flavus and Aspergillus parasiticus. Control measures to curtail the contamination of aflatoxin in food products is still a challenge. Although there are several reports on the antifungal peptides, there is no specific study on the action of antifungal peptides on aflatoxin synthesis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781193001
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http://dx.doi.org/10.1016/j.peptides.2019.02.006DOI Listing
February 2019
8 Reads

Microinjection of 26RFa, an endogenous ligand for the glutamine RF-amide peptide receptor (QRFP receptor), into the rostral ventromedial medulla (RVM), locus coelureus (LC), and periaqueductal grey (PAG) produces an analgesic effect in rats.

Peptides 2019 Feb 14;115:1-7. Epub 2019 Feb 14.

Department of Anesthesiology, School of Medical Science, Kumamoto University, 1-1-1 Honjo, Kumamoto-shi, Kumamoto, 860-8556, Japan. Electronic address:

26RFa is an endogenous ligand for the QRFP receptor. We previously found that intracerebroventricular injection of 26RFa produces an analgesic effect in a rat formalin test. In the present study, we directly tested the hypothesis that the analgesic effects of 26RFa in the formalin test are mediated in well-recognized regions of the descending inhibitory pain pathways, such as the rostral ventromedial medulla (RVM), locus coeruleus (LC), and periaqueductal grey (PAG) in rats. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.02.003DOI Listing
February 2019

Validation of antibody-based assays for regulatory peptides: do it once, get it right, and exploit the under-appreciated benefit of long-term antibody stability.

Authors:
Graham Dockray

Peptides 2019 Feb 13. Epub 2019 Feb 13.

Physiological Laboratory, Department of Cellular and Molecular Physiology, University of Liverpool, Crown St, Liverpool, L69 3BX, UK.. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2019.02.001DOI Listing
February 2019

Fungi-derived lipopeptide antibiotics developed since 2000.

Peptides 2019 03 7;113:52-65. Epub 2019 Feb 7.

College of Chemical Engineering and Pharmacy, Henan University of Science and Technology, Luoyang, 471023, China.

Lipopeptide antibiotics have linear or cyclic structures with one or more hydrocarbon tails linked to the N-terminus of a short oligopeptide that may be chemically modified and/or contain unusual amino acid residues in their structures. They possess huge potential as pharmaceutical drugs and biocontrol agents, and ˜30 representative genera of fungi are known to produce them. Some chemically synthesised derivatives have already been developed into commercial products or subjected to clinical trials, including cilofungin, caspofungin, micafungin, anidulafungin, rezafungin, emodepside, fusafungine and destruxins. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.02.002DOI Listing
March 2019
7 Reads

Orexin A modulates prolactin production by regulating BMP-4 activity in rat pituitary lactotorope cells.

Peptides 2019 03 2;113:35-40. Epub 2019 Feb 2.

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan. Electronic address:

The impact of orexins on anterior pituitary function has yet to be clarified. We studied the effects of orexin A and its interaction with the bone morphogenetic protein (BMP) system on the regulatory role of prolactin synthesis using rat lactotrope GH3 cells expressing BMP-4. Orexin type 1 receptor (OX1R), but not type 2 receptor (OX2R), was predominantly expressed in GH3 cells. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.01.002DOI Listing
March 2019
1 Read

The effects of both age and sex on irisin levels in paired plasma and cerebrospinal fluid in healthy humans.

Peptides 2019 03 1;113:41-51. Epub 2019 Feb 1.

Shanghai Institute of Geriatrics and Gerontology, Shanghai Key Laboratory of Clinical Geriatrics, Department of Geriatrics, Huadong Hospital, and Research Center of Aging and Medicine, Shanghai Medical College, Fudan University, Shanghai 200040, China. Electronic address:

Background: Adipo-myokine irisin has important effects on the metabolism and functioning of multiple tissues and organs. However, the effects of aging and sex on irisin levels in cerebrospinal fluid (CSF) and on circulation have not been comprehensively studied.

Objective: To investigate whether aging and sex can affect irisin levels in both CSF and plasma; to determine whether CSF irisin uptake involves a saturable transport mechanism. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.01.004DOI Listing
March 2019
2 Reads

The L cell transcriptome is unaffected by vertical sleeve gastrectomy but highly dependent upon position within the gastrointestinal tract.

Peptides 2019 03 17;113:22-34. Epub 2019 Jan 17.

Laboratory of Organic Chemistry, ETH Zurich, Schorenstrasse 16, 8603, Schwerzenbach, Switzerland. Electronic address:

Altered GLP-1 secretion from L cells has been implicated in the development of type 2 diabetes mellitus and its resolution following bariatric surgery. However, changes in L cell gene expression, which may form the basis for altered functionality after high fat diet (HFD) or bariatric surgery, have either not been investigated or have given conflicting results. We developed a gcg-DTR-eGFP reporter mouse to isolate ileal and colonic L cells from HFD fed insulin resistant mice and mice showing improved glucose tolerance following vertical sleeve gastrectomy (VSG). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781193000
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http://dx.doi.org/10.1016/j.peptides.2019.01.001DOI Listing
March 2019
15 Reads

Host-defense peptides AC12, DK16 and RC11 with immunomodulatory activity isolated from Hypsiboas raniceps skin secretion.

Peptides 2019 03 2;113:11-21. Epub 2019 Jan 2.

Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia da Universidade Católica de Brasília, Brasília, Brazil; Curso de Odontologia, Universidade Católica de Brasília, Brasília, Brazil; Programa de Pós-graduação em Ciências da Saúde, Universidade de Brasília, Brasília, Brazil. Electronic address:

Inflammation is a natural defense mechanism of the immune system; however, when unregulated, it can lead to chronic illness. Glucocorticoids are the most commonly used agents to effectively treat inflammatory conditions, including autoimmune diseases, however these substances can trigger a number of side effects. Thus, viable alternatives to the use of these drugs would be advantageous. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.12.007DOI Listing
March 2019
5 Reads
2.618 Impact Factor

Differential effects of hypo- and hyperthyroidism on remodeling of contacts between neurons expressing the neuropeptide EI and tyrosine hydroxylase in hypothalamic areas of the male rat.

Peptides 2019 03 24;113:1-10. Epub 2018 Dec 24.

Laboratorio de Neurobiología, Instituto de Embriología e Histología (IHEM-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo (UNCuyo), 5500, Mendoza, Argentina.

The Neuropeptide EI (NEI, glutamic acid- isoleucine amide) participates in neuroendocrine function. Previously we demonstrated that NEI concentration is regulated by thyroid hormones in discrete hypothalamic areas in rats. We observed that the thyroid status affects the dopaminergic regulation of the pituitary hormones. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.12.008DOI Listing
March 2019
3 Reads

The polymyxin derivative NAB739 is synergistic with several antibiotics against polymyxin-resistant strains of Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii.

Peptides 2019 02 23;112:149-153. Epub 2018 Dec 23.

Northern Antibiotics Ltd, FI-02150, Espoo, Finland; Department of Bacteriology and Immunology, Helsinki University Medical School, FI-00014, Helsinki, Finland. Electronic address:

The antibiotic crisis has reinstated polymyxins, once abandoned because of their toxicity. Now, preclinical studies have revealed better tolerated and more effective derivatives of polymyxins such as NAB739. Simultaneously, polymyxin-resistant (PMR) strains such as the mcr-1 strains have received lots of justified publicity, even though they are still very rare. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.12.006DOI Listing
February 2019
15 Reads

Superoxide anions modulate the performance of apelin in the paraventricular nucleus on sympathetic activity and blood pressure in spontaneously hypertensive rats.

Peptides 2018 Dec 21. Epub 2018 Dec 21.

Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China. Electronic address:

The present study was designed to determine how apelin in paraventricular nucleus (PVN) modulates the renal sympathetic nerve activity (RSNA), arterial blood pressure (ABP), mean arterial pressure (MAP), and heart rate (HR), and whether superoxide anions regulate the performance of PVN apelin in spontaneously hypertensive rats (SHRs). Acute experiment was carried out with 13-week-old male Wistar-Kyoto rats (WKY) and SHRs under anaesthesia. RSNA, ABP, MAP and HR after PVN microinjection were measured. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.12.005DOI Listing
December 2018
3 Reads

Centrally administered kisspeptin suppresses feeding via nesfatin-1 and oxytocin in male rats.

Peptides 2019 02 16;112:114-124. Epub 2018 Dec 16.

Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan. Electronic address:

Kisspeptin (KP), known as a hypothalamic neuropeptide, plays a critical role in the regulation of not only reproduction but also food intake. The anorectic neuropeptides, nesfatin-1 and oxytocin (OXT), are expressed in central nervous system, particulaly in various hypothalamic nuclei, and peripheral tissue. We examined the effects of the intracerebroventricular (icv) administration of KP-10 on feeding and nesfatin-1-immunoreactive (ir) or OXT-ir neurons in the rat hypothalamus, using Fos double immunohistochemistry in male rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183024
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http://dx.doi.org/10.1016/j.peptides.2018.12.003DOI Listing
February 2019
15 Reads

Exploiting endogenous opioids: Lessons learned from endomorphin 2 in the female rat.

Peptides 2019 02 14;112:133-138. Epub 2018 Dec 14.

Department of Neuroscience, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.

Effective management of chronic pain is demanded by ethical as well as medical considerations. Although opioid analgesics remain among the most effective pharmacotherapies for ameliorating many types of pain, their use is clouded by concerns regarding their addictive properties, underscored by the current epidemic of prescription opioid abuse and attendant deaths. Medicinal harnessing of endogenous opioid antinociception could provide a strategy for continuing to take advantage of the powerful antinociceptive properties of opioids while avoiding their abuse potential. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.12.002DOI Listing
February 2019
1 Read

Epinecidin-1: A marine fish antimicrobial peptide with therapeutic potential against Trichomonas vaginalis infection in mice.

Peptides 2019 02 12;112:139-148. Epub 2018 Dec 12.

Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, Kaohsiung 811, Taiwan. Electronic address:

Trichomoniasis is caused by infection with the protozoan parasite Trichomonas vaginalis, and prolonged persistence may lead to serious ill effects in patients. Thus, the development of new therapeutic strategies to combat drug-resistant T. vaginalis would be clinically beneficial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183024
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http://dx.doi.org/10.1016/j.peptides.2018.12.004DOI Listing
February 2019
19 Reads

NOP agonist action of cebranopadol counteracts its liability to promote physical dependence.

Peptides 2019 02 12;112:101-105. Epub 2018 Dec 12.

Department of Medical Sciences, Section of Pharmacology, and National Institute of Neuroscience, University of Ferrara, Ferrara, Italy. Electronic address:

Cebranopadol is a mixed NOP/opioid receptor agonist currently under development as innovative analgesic. In this study the liability of cebranopadol to produce opioid-type physical dependence has been evaluated in comparison with morphine in wild type mice and in mice knockout for the NOP receptor gene (NOP(-/-)). Mice were treated twice a day for 5 days with increasing doses of cebranopadol or morphine (cumulative doses 10. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183024
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http://dx.doi.org/10.1016/j.peptides.2018.12.001DOI Listing
February 2019
12 Reads

Genetic loss of proadrenomedullin N-terminal 20 peptide (PAMP) in mice is compatible with survival.

Peptides 2019 02 8;112:96-100. Epub 2018 Dec 8.

Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 111 Mason Farm Road, CB 7545, Chapel Hill, NC, 27599, USA. Electronic address:

Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are small peptides derived from a common precursor, pre-proadrenomedullin. Although AM and PAMP share hypotensive effects in the cardiovascular system, the peptides also exert diverse and distinct effects on endocrine physiology, innate immunity, cytoskeletal biology and receptor signaling pathways. Tremendous knowledge has been gleaned from the study of several genetic animal models of AM deletion or overexpression, some of which also simultaneously delete the coding region for PAMP peptide. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362461PMC
February 2019
13 Reads

Efficacy of lanthionine-stabilized angiotensin-(1-7) in type I and type II diabetes mouse models.

Peptides 2019 02 4;112:78-84. Epub 2018 Dec 4.

Constant Pharmaceuticals LLC, 398 Columbus Ave, PMB 507, Boston, MA, 02116, USA.

Native angiotensin-(1-7) exerts many therapeutic effects. However, it is rapidly degraded by ACE and other peptidases. This drawback is largely eliminated for lanthionine-stabilized angiotensin-(1-7), termed cAng-(1-7), which is fully resistant to ACE and has strongly increased resistance to other peptidases. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.10.015DOI Listing
February 2019
1 Read

Peptides combined - physiology revisited!

Peptides 2018 12;110:A1-A2

Institute of Biomedicine and Biocenter of Oulu, Medical Research Center and University Hospital, University of Oulu, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2018.11.001DOI Listing
December 2018
2 Reads

Identification of expression and function of the glucagon-like peptide-1 receptor in colonic smooth muscle.

Peptides 2019 02 30;112:48-55. Epub 2018 Nov 30.

Department of Physiology and Biophysics, VCU Program in Enteric Neuromuscular Sciences, Virginia Commonwealth University, Box 980551, Richmond, VA, 23298, United States. Electronic address:

The insulinotropic effects of the incretin hormone, glucagon-like peptide-1 (GLP-1) are mediated via GLP-1 receptors (GLP-1R) present on pancreatic β cells. GLP-1 causes a decrease in the motility of stomach and intestine which involves both central and peripheral nervous systems. The expression and function of GLP-1R in gastrointestinal smooth muscle, however, are not clear. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342651PMC
February 2019
6 Reads

High doses of ANP and BNP exacerbate lipolysis in humans and the lipolytic effect of BNP is associated with cardiac triglyceride content in pigs.

Peptides 2019 02 30;112:43-47. Epub 2018 Nov 30.

Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Cardiorenal physiology (Mayo Clinic, Rochester, MN, USA; Copenhagen University, Denmark.

Drugs facilitating the cardioprotective effects of natriuretic peptides are introduced in heart failure treatment. ANP and BNP also stimulate lipolysis and increase circulating concentrations of free fatty acids (FFAs); an aspect, however, thought to be confined to primates. We examined the lipolytic effect of natriuretic peptide infusion in healthy young men and evaluated the effect in a porcine model of myocardial ischemia and reperfusion. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.11.003DOI Listing
February 2019
3 Reads

Antimicrobial peptide KSL-W and analogues: Promising agents to control plant diseases.

Peptides 2019 02 30;112:85-95. Epub 2018 Nov 30.

LIPPSO, Department of Chemistry, University of Girona, Campus Montilivi, Girona, Spain. Electronic address:

Recent strong restrictions on the use of pesticides has prompted the search for safer alternatives, being antimicrobial peptides promising candidates. Herein, with the aim of identifying new agents, 15 peptides reported as plant defense elicitors, promiscuous, multifunctional or antimicrobial were selected and tested against six plant pathogenic bacteria of economic importance. Within this set, KSL-W (KKVVFWVKFK-NH) displayed high antibacterial activity against all the tested pathogens, low hemolysis and low phytotoxicity in tobacco leaves. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183024
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http://dx.doi.org/10.1016/j.peptides.2018.11.009DOI Listing
February 2019
18 Reads

Liraglutide inhibited AGEs induced coronary smooth muscle cell phenotypic transition through inhibiting the NF-κB signal pathway.

Peptides 2019 02 1;112:125-132. Epub 2018 Dec 1.

Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, China.

Vascular smooth muscle cell (VSMC) phenotype transition is involved in diabetes-associated cardiovascular diseases. The mechanism of VSMCs phenotypic transition in T2DM was still unclear. Rat coronary artery SMCs were pretreated with liraglutide alone, liraglutide and H89(a PKA inhibitor), neutralizing anti-RAGE antibody or the antioxidant pyrrolidine dithiocarbamate (PDTC; a nuclear factor-κB (NF-κB) inhibitor), followed by treatment with AGE. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.11.008DOI Listing
February 2019
2 Reads

Biochemical and pharmacological investigation of novel nociceptin/OFQ analogues and N/OFQ-RYYRIK hybrid peptides.

Peptides 2019 02 1;112:106-113. Epub 2018 Dec 1.

Institute of Biochemistry, Biological Research Center, Hungarian Academy of Sciences, H-6726 Szeged, Temesvári krt. 62., Hungary. Electronic address:

The endogenous ligand nociceptin (N/OFQ) and a positively charged synthetic peptide RYYRIK are both selective for the nociceptin opioid receptor (NOPr). Despite their structural dissimilarity, N/OFQ and RYYRIK compete for the same binding site of NOP receptor possessing full and partial agonistic character, respectively. In the view of the message-address concept, hybrid peptide constructs were probed for the NOP receptor combining different regions of N/OFQ and RYYRIK related peptide sequences. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183024
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http://dx.doi.org/10.1016/j.peptides.2018.11.010DOI Listing
February 2019
2 Reads

The effect of halogenation on the antimicrobial activity, antibiofilm activity, cytotoxicity and proteolytic stability of the antimicrobial peptide Jelleine-I.

Peptides 2019 02 27;112:56-66. Epub 2018 Nov 27.

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, School of Life Sciences, Lanzhou University, 222 Tian Shui South Road, Lanzhou, 730000, PR China. Electronic address:

Antimicrobial peptides (AMPs) are believed to be a promising class of antimicrobial agents against bacteria and fungi. To promote the clinical use of AMPs, their antimicrobial activity and susceptibility to protease degradation should be further improved. The antimicrobial peptide Jelleine-I was originally isolated from the royal jelly of honeybees (Apis mellifera) with a short sequence of PFKLSLHL-NH (953. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.11.006DOI Listing
February 2019
4 Reads
2.618 Impact Factor

Active-site directed peptide l-Phe-d-His-l-Leu inhibits angiotensin converting enzyme activity and dexamethasone-induced hypertension in rats.

Peptides 2019 02 24;112:34-42. Epub 2018 Nov 24.

Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru, 570 006, India. Electronic address:

Hypertension is the fundamental cause of cardiovascular and cerebrovascular disorders. Several natural and synthetic peptides are being used as antihypertensive agents, which target angiotensin converting enzyme (ACE), the master regulator of angiotensin (Ang) II production. In this study, we have evaluated ACE-inhibitory potential of the tripeptide l-Phenylalanyl-d-Histidyl-l-Leucine (l-Phe-d-His-l-Leu) in vitro and its antihypertensive effect in rat model of dexamethasone-induced hypertension. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.11.002DOI Listing
February 2019
3 Reads

Towards establishing a higher acceptance rate for PEPTIDES - The peer review process and criteria for acceptance or rejection.

Peptides 2019 02 24;112:32-33. Epub 2018 Nov 24.

Institute of Biomedicine and Biocenter of Oulu, Oulu University, Finland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183023
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http://dx.doi.org/10.1016/j.peptides.2018.11.004DOI Listing
February 2019
6 Reads

Inhibition of peptide BF-30 on influenza A virus infection in vitro/vivo by causing virion membrane fusion.

Peptides 2019 02 14;112:14-22. Epub 2018 Nov 14.

School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, 210009, PR China. Electronic address:

Influenza A virus is a leading cause of mortality in humans and poses a global health emergency due to its newly adapted and resistant strains. Thus, there is an urgency to develop novel anti-influenza drugs. Peptides are a type of biological molecule having a wide range of inhibitory effects against bacteria, fungi, viruses and cancer cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183018
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http://dx.doi.org/10.1016/j.peptides.2018.10.004DOI Listing
February 2019
14 Reads

The effects of the urocortins on the hypothalamic-pituitary-adrenal axis - similarities and discordancies between rats and mice.

Peptides 2019 02 8;112:1-13. Epub 2018 Nov 8.

Department of Pathophysiology, Faculty of Medicine, University of Szeged, Hungary.

The urocortins (Ucn I, Ucn II and Ucn III) are structural analogues of corticotropin-releasing factor (CRF). The aim of our present experiments was to compare the effects of the urocortins on the hypothalamic-pituitary-adrenal (HPA) axis in rats and mice, including the hypothalamic adrenocorticotropic hormone (ACTH) secretagogues, such as CRF and arginine vasopressin (AVP). Therefore, male CFLP mice and male Wistar rats were injected intracerebroventricularly (icv) with 0. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.10.014DOI Listing
February 2019
2 Reads

Cocaine- and amphetamine-regulated transcript (CART): A multifaceted neuropeptide.

Peptides 2018 12 1;110:56-77. Epub 2018 Nov 1.

Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Institute, Tehran University of Medical Science, Tehran, Iran. Electronic address:

Over the last 35 years, the continuous discovery of novel neuropeptides has been the key to the better understanding of how the central nervous system has integrated with neuronal signals and behavioral responses. Cocaine and amphetamine-regulated transcript (CART) was discovered in 1995 in the rat striatum but later was found to be highly expressed in the hypothalamus. The widespread distribution of CART peptide in the brain complicated the understanding of the role played by this neurotransmitter. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.10.008DOI Listing
December 2018
16 Reads

Determinants of opioid abuse potential: Insights using intracranial self-stimulation.

Peptides 2019 02 1;112:23-31. Epub 2018 Nov 1.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond VA 23298, United States.

Intracranial self-stimulation (ICSS) is one procedure that can be used for preclinical abuse potential assessment. In ICSS procedures, subjects with microelectrodes implanted into a brain-reward region are trained to press an operant response lever for pulses of electrical brain stimulation, and drugs are evaluated for their effectiveness to increase or "facilitate" ICSS responding (an abuse-related effect) or to depress ICSS responding (an abuse-limiting effect). ICSS has been used for decades to evaluate determinants of opioid abuse potential, and this article reviews pharmacological and biological determinants of opioid abuse potential as revealed by ICSS studies in rodents. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183019
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http://dx.doi.org/10.1016/j.peptides.2018.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342636PMC
February 2019
34 Reads

The role of CNP-mediated PKG/PKA-PLCβ pathway in diabetes-induced gastric motility disorder.

Peptides 2018 12 1;110:47-55. Epub 2018 Nov 1.

Department of Physiology, Yanbian University School of Medicine, 977 Gongyuan, Road, Jilin, Yanji 133002, China. Electronic address:

Our previous work demonstrated that the C-type natriuretic peptide (CNP)/cyclic guanosine monophosphate (cGMP)/cyclic adenosine monophosphate (cAMP) pathway in gastric antrum smooth muscle of rats with diabetes was upregulated and played an important role in the development of diabetic gastric dysmotility. Our goal for this study was to explore the downstream signaling pathways of CNP. We found that the expressions of protein kinase G (PKG) and protein kinase A (PKA) in gastric smooth muscle tissue of rats with diabetes were significantly upregulated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183019
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http://dx.doi.org/10.1016/j.peptides.2018.10.012DOI Listing
December 2018
18 Reads

Analgesic activities of the mixed opioid and NPFF receptors agonist DN-9 in a mouse model of formalin-induced orofacial inflammatory pain.

Peptides 2018 12 1;110:30-39. Epub 2018 Nov 1.

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, China. Electronic address:

Orofacial pain is one of the most common pain conditions and compromises the quality of life of the sufferer. Several studies have shown that opioid agonists produced significant analgesia in the orofacial pain, and combination of opioids with drugs belonging to other classes induced synergism in the orofacial pain. However, combination therapy of different analgesic drugs improves the risk of drug-drug interactions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183019
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http://dx.doi.org/10.1016/j.peptides.2018.10.010DOI Listing
December 2018
7 Reads