88,052 results match your criteria Peptic Ulcer Disease


Investigation the levels of endotoxin and 8-hydroxy-2'-deoxyguanosine in sera of patients with Helicobacter pylori positive peptic ulcer.

Int J Clin Pract 2021 Jun 12:e14501. Epub 2021 Jun 12.

Harran University, Faculty of Medicine, Dept. of Medical Biochemistry, Şanlıurfa.

Background: Peptic ulcer is considered an important public health problem and generally associated with complicated conditions such as bleeding and perforation. The aim of this study is to reflect the rate of oxidative damage in the body among dyspeptic patients with H. pylori-positive peptic ulcer by measuring 8-hydroxy-2'-deoxyguanosine (8-OHdG) level in serum samples and its association with the level of bacterial endotoxin. Read More

View Article and Full-Text PDF

Increased risk of short-term depressive disorder after Helicobacter pylori eradication: A population-based nested cohort study.

Helicobacter 2021 Jun 11:e12824. Epub 2021 Jun 11.

Institute of Brain Science, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan.

Background: Depressive disorder is a major psychiatric illness, and a disturbed brain-gut-microbiome axis may contribute to its pathophysiology. Chronic Helicobacter pylori (H. pylori) infections are common in the general population and using multiple antibiotics is required for its eradication, which is associated with gut dysbiosis and may lead to depression. Read More

View Article and Full-Text PDF

Cost-effectiveness analysis of Anti-IL-5 therapies of severe eosinophilic asthma in Spain.

J Med Econ 2021 Jun 11. Epub 2021 Jun 11.

Full Professor in the Medicine and Specialities Department, Universidad de Alcalá (Alcalá de Henares, Madrid). Hospital Universitario Guadalajara, Guadalajara, Spain.

Aim: To analyse the cost-effectiveness of MEP with standard of care (SoC) versus other anti-IL-5 therapies approved for the treatment of severe eosinophilic asthma (SEA) patients, within the Spanish National Health System (NHS) perspective.

Methods: a Markov model with a 4-week cycle length was used to compare MEP with BEN and RES as therapies added to SoC in the management of SEA, in terms of cost per QALY gained and incremental cost-effectiveness ratio (ICER). Costs (€2019) were obtained from public sources, while utilities and transition probabilities were retrieved from literature, e. Read More

View Article and Full-Text PDF

Interactions between and the Gastric Microbiome: Impact on Gastric Homeostasis and Disease.

Curr Opin Physiol 2021 Jun 24;21:57-64. Epub 2021 Apr 24.

Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717.

Like many seemingly inhospitable environments on our planet, the highly acidic human stomach harbors a diverse bacterial microflora. The best-known member of the human gastric flora, , causes a number of gastric diseases, including peptic ulcer disease and gastric adenocarcinoma. In the absence of infection, the gastric microbiota displays some features similar to the oral cavity with Firmicutes the most common phylum, followed by Proteobacteria and Bacteroidetes. Read More

View Article and Full-Text PDF

Prophylactic transcatheter arterial embolization for high-risk ulcers following endoscopic hemostasis: a meta-analysis.

World J Emerg Surg 2021 Jun 10;16(1):29. Epub 2021 Jun 10.

Division of Interventional Radiology, Department of Radiology, University of Chicago, Chicago, IL, USA.

Background: To conduct a meta-analysis to assess the safety and efficacy of prophylactic transcatheter arterial embolization (PTAE) for the treatment of high-risk bleeding peptic ulcers after achieving endoscopic hemostasis.

Methods: PubMed and Cochrane Library were queried for full-text articles published up to December 2019. The following keywords were used: "prophylactic embolization", "supplement embolization", "gastrointestinal bleeding", and "ulcer bleeding". Read More

View Article and Full-Text PDF

Prevalence of infection and the incidence of the associated malignant and peptic ulcer disease (PUD) at Nelson Mandela Academic Hospital: a retrospective analysis.

Authors:
Stephen Z Molaoa

J Drug Assess 2021 Feb 8;10(1):57-61. Epub 2021 Feb 8.

Walter Sisulu University and Nelson Mandela Academic Hospital, Department of Surgery, and Department of Health Studies, University of South Africa, Mthatha, South Africa.

Background: infection is associated with both benign and malignant gastrointestinal diseases. However, no studies have been conducted locally describing the prevalence of and its associated GIT diseases. The objectives of this study are to determine the prevalence of , and the incidence of PUD and gastric malignancies among patients who are infected with or who have the stigmata of previous exposure to . Read More

View Article and Full-Text PDF
February 2021

Prognosis of variceal and non-variceal upper gastrointestinal bleeding in already hospitalised patients: Results from a French prospective cohort.

United European Gastroenterol J 2021 Jun 8. Epub 2021 Jun 8.

Groupe Hospitalier Intercommunal Le Raincy-Montfermeil, Montfermeil, France.

Objectives: Patients who develop upper gastrointestinal bleeding (UGIB) while in hospital appear to have a poor prognosis. Our study aims at analysing the difference in outcome between in-patients (IPs) and out-patients presenting with variceal and non-variceal UGIB.

Methods: We conducted a multicentre prospective study by collecting data about variceal and non-variceal UGIB cases through 46 hospitals in France between November 2017 and October 2018. Read More

View Article and Full-Text PDF

How Would You Manage This Patient With Nonvariceal Upper Gastrointestinal Bleeding? : Grand Rounds Discussion From Beth Israel Deaconess Medical Center.

Ann Intern Med 2021 06 8;174(6):836-843. Epub 2021 Jun 8.

Beth Israel Deaconess Medical Center, Boston, Massachusetts (Z.K., T.M.B., R.B.B.).

Nonvariceal upper gastrointestinal bleeding is common, morbid, and potentially fatal. Cornerstones of inpatient management include fluid resuscitation; blood transfusion; endoscopy; and initiation of proton-pump inhibitor therapy, which continues in an individualized manner based on risk factors for recurrent bleeding in the outpatient setting. The International Consensus Group released guidelines on the management of nonvariceal upper gastrointestinal bleeding in 2019. Read More

View Article and Full-Text PDF

A case report of gastric volvulus, a rare cause of acute abdomen.

Radiol Case Rep 2021 Jul 26;16(7):1907-1911. Epub 2021 May 26.

Radiology Department of Hospital Universiti Kebangsaan Malaysia, UKM. Kuala Lumpur, Malaysia.

Gastric volvulus is an uncommon disorder with an unknown incidence, unless it stays in the back of the diagnostician's mind, diagnosis of gastric volvulus, which can have significant morbidity and mortality associated with it, can be easily missed and can present either in the acute or chronic setting with variable symptoms. When it occurs in the acute scenario, patients present with severe epigastric pain and retching without vomiting. Together with inability to pass nasogastric tube, they constitute Borchardt's triad. Read More

View Article and Full-Text PDF

Biopsy in emergency gastroscopy does not increase the risk of rebleeding in patients with Forrest I acute nonvariceal upper gastrointestinal bleeding combined with suspected malignant gastric ulcer: a multicenter retrospective cohort study.

BMC Gastroenterol 2021 Jun 6;21(1):250. Epub 2021 Jun 6.

Department of Gastroenterology, Xuanwu Hospital of Capital Medical University, 45 Chang-chun Street, Beijing, 100053, China.

Background: Few studies have reported whether a biopsy in emergency gastroscopy (EG) increased the risk of rebleeding in patients with Forrest I acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) combined with suspected malignant gastric ulcer (SMGU). This study aims to conduct a multicenter retrospective cohort study using propensity score matching to verify whether a biopsy in EG increases the risk of rebleeding in patients diagnosed with Forrest I ANVUGIB combined with SMGU.

Methods: Using the data for propensity-matched patients, logistic regression models were fitted using rebleeding as the dependent variable. Read More

View Article and Full-Text PDF

Primary closure versus Graham patch omentopexy in perforated peptic ulcer: A systematic review and meta-analysis.

Surgeon 2021 Jun 2. Epub 2021 Jun 2.

Department of General and Colorectal Surgery, Good Hope Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Background: There are different methods to repair a perforated peptic ulcer, the two most frequently used are the Graham patch omentopexy and the primary closure. Currently there is no high-level evidence to provide guidance of the optimal method of repair. The aim of this study is to compare the outcomes of the two methods so as to provide improved guidance for surgeons undertaking this repair. Read More

View Article and Full-Text PDF

Long-term continuous use of proton-pump inhibitors is associated with renal function decline in patients without acute kidney injury.

Clin Exp Nephrol 2021 Jun 5. Epub 2021 Jun 5.

Center of Medical Information Science, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Japan.

Background: Proton-pump inhibitors (PPIs) are widely used to treat gastroesophageal reflex disease, peptic ulcer disease, and stress ulcer prophylaxis. This study estimated the progress rate of renal dysfunction in patients taking PPIs in clinical settings and compared the results with those of patients taking histamine-2 receptor antagonists (H2RAs).

Methods: We retrospectively reviewed patients' data collected from Kochi Medical School Hospital's information system between 2001 and 2019. Read More

View Article and Full-Text PDF

Evaluation of the effect of hydroalcoholic and flavonoid-enriched extracts of on indomethacin-induced gastric ulcer in rats.

Res Pharm Sci 2021 Apr 5;16(2):141-152. Epub 2021 Mar 5.

Department of Clinical Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.

Background And Purpose: () is a fragrant wild medicinal plant found in Iran. Traditionally, it is used for the treatment of rheumatism, asthma, and gastrointestinal ailments. So far no investigation has been done on the beneficial or side effects of on peptic ulcer. Read More

View Article and Full-Text PDF

Evaluation of safety and pharmacokinetics of bismuth-containing quadruple therapy with either vonoprazan or lansoprazole for Helicobacter pylori eradication.

Br J Clin Pharmacol 2021 Jun 3. Epub 2021 Jun 3.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.

Aim: Helicobacter pylori (Hp) eradication plays a key role in the treatment and prevention of peptic ulcer diseases. Increasing clarithromycin resistance in Hp necessitates more effective treatments for eradication, such as bismuth-containing quadruple therapy. We aimed to compare the safety and pharmacokinetics (PK) of bismuth between vonoprazan- and lansoprazole-containing quadruple therapy in Hp-positive subjects. Read More

View Article and Full-Text PDF

Empiric antifungals do not decrease the risk for organ space infection in patients with perforated peptic ulcer.

Trauma Surg Acute Care Open 2021 19;6(1):e000662. Epub 2021 May 19.

Department of Surgery, Texas Tech University Health Sciences Center School of Medicine-Lubbock Campus, Lubbock, Texas, USA.

Introduction: Infection control in patients with perforated peptic ulcers (PPU) commonly includes empiric antifungals (AF). We investigated the variation in the use of empiric AF and explored the association between their use and the subsequent development of organ space infection (OSI).

Methods: This was a secondary analysis of a multicenter, case-control study of patients treated for PPU at nine institutions between 2011 and 2018. Read More

View Article and Full-Text PDF

What Is New in Diagnosis. An Overview.

J Clin Med 2021 May 13;10(10). Epub 2021 May 13.

Dipartimento di Scienze Mediche, Chirurgiche e Sperimentali, University of Sassari, 07100 Sassari, Italy.

infection remains one of the most prevalent infections worldwide, especially in low-resource countries, and the major risk factor for peptic ulcer and gastric cancer. The "test-and-treat" strategy is recommended by several guidelines and consensus. The choice of testing method is based on patient age, presence of alarm signs and/or symptoms, use of non-steroidal anti-inflammatory drugs, as well as local availability, test reliability, and cost. Read More

View Article and Full-Text PDF

Feasibility of Upper Gastrointestinal Examination in Home Care Setting with a Magnetically Assisted Capsule Endoscopy System: A Retrospective Study.

Healthcare (Basel) 2021 May 13;9(5). Epub 2021 May 13.

Graduate Institute of Business Administration, Fu Jen Catholic University, New Taipei 242, Taiwan.

The magnetic assisted capsule endoscope (MACE) with a hand-held magnetic field navigator (MFN) for upper gastrointestinal examination achieved satisfactory results in a healthy volunteer study. We evaluated the feasibility of upper gastrointestinal examination in the home care setting with the MACE system. Home care patients with upper gastrointestinal symptoms that received an MACE exam were enrolled in the study. Read More

View Article and Full-Text PDF

Effectiveness of the polyphenols-rich Sedum dendroideum infusion on gastric ulcer healing in rats: Roles of protective endogenous factors and antioxidant and anti-inflammatory mechanisms.

J Ethnopharmacol 2021 May 29;278:114260. Epub 2021 May 29.

Department of Pharmacology, Federal University of Parana, Curitiba, PR, Brazil. Electronic address:

Ethnopharmacological Relevance: Peptic ulcer is an inflammatory disease that therapeutic options are mainly focused in antisecretory drugs. Sedum dendroideum Moc & Sessé ex DC (Crassulaceae) is employed in folk medicine for the treatment of gastric ulcers. Recently, our group demonstrated that Sedum dendroideum infusion (SDI) is rich in polyphenols (flavonol glycosides, myricetin, quercetin and kaempferol) and promoted gastroprotection against acute ulcer models, without changes gastric acid secretion. Read More

View Article and Full-Text PDF

Persisting bleeding from the duodenal ulcer in patients with occlusion of the celiac trunk: a case report.

Pol Przegl Chir 2020 Oct;93(2):1-5

Department of Imaging Diagnostics and Interventional Radiology, Pomeranian Medical University in Szczecin, Poland.

Introduction: Endoscopic measures have continued to be the primary procedures in the management of ulcer bleeding. Nevertheless, in cases of failed endoscopic hemostasis and re-bleedings, endovascular techniques have gradually gained increased acceptance as an alternative to surgery, allowing to avoid surgical intervention in some cases. <br/> Case report: A case of a 42-year-old patient presenting to the authors' institution with massive bleeding from the duodenal ulcer, sprang from a pathologically enlarged gastroduodenal artery is reported. Read More

View Article and Full-Text PDF
October 2020

Complicated Ventral Hernia: A Perquisite for Perforated Peptic Ulcer-Unusual Clinical Scenario.

Surg J (N Y) 2021 Apr 25;7(2):e66-e68. Epub 2021 May 25.

Department of General Surgery, Seth G.S. Medical College & KEM Hospital, Parel, Mumbai, Maharashtra, India.

 Peptic ulcer usually presents to the emergency in the form of an acute abdomen, which is usually diagnosed easily either clinically or radiologically. Although its incidence has decreased with the introduction on proton pump inhibitors it is still one of the most common emergencies encountered by a surgeon.  A 60-year-old woman complained of epigastric swelling for 6 months which gradually increased and became irreducible over the last 2 months. Read More

View Article and Full-Text PDF

A Fast and Reliable Method to Interpret Short-Term Mortality in Perforated Peptic Ulcer: Red Cell Distribution Width is Sensitive and Specific.

Surg Res Pract 2021 18;2021:5542619. Epub 2021 May 18.

Department of Surgery, University of Health Sciences, Haseki Training and Research Hospital, Istanbul, Turkey.

Introduction: Peptic ulcer is an important health problem worldwide with a prevalence of around 5%. Peptic ulcer perforation is a potentially mortal complication of peptic ulcer disease. We aimed to investigate the potential use of red cell distribution width as a prognostic marker in peptic ulcer perforation. Read More

View Article and Full-Text PDF

Surgery for Perforated Peptic Ulcer: Is Laparoscopy a New Paradigm?

Minim Invasive Surg 2021 12;2021:8828091. Epub 2021 May 12.

General Surgery Department, São João University Medical Center, Porto, Portugal.

Introduction: Laparoscopic repair of perforated peptic ulcer (PPU) remains controversial mainly due to its safety and applicability in critically ill patients. The aim of this study is to compare the outcomes of laparoscopy versus laparotomy in the treatment of PPU.

Methods: Single-institutional, retrospective study of all patients submitted to surgical repair of PPU between 2012 and 2019. Read More

View Article and Full-Text PDF

Subhepatic appendix: an ectopic topography not to be disregarded: a case report.

J Med Case Rep 2021 May 31;15(1):288. Epub 2021 May 31.

Department of Surgery, Regional Hospital Center of Maradi, Faculty of Health Sciences of the University of Maradi, Maradi, Niger.

Introduction: Subhepatic appendix is most often due to an anomaly of rotation of the primary intestine occurring during embryogenesis. This ectopic topography associated with advanced age can be a serious diagnosis problem at the stage of appendicitis or appendicular peritonitis.

Case Presentation: We report the case of a 60-year-old melanoderm man, with a history of urinary pathology and peptic ulcer, referred from a health district for abdominal pain of the right hypochondrium evolving for about 5 days, secondarily generalized, in whom we suspected peritonitis, the etiology of which remains to be determined. Read More

View Article and Full-Text PDF

Epidemiology of Barrett's Esophagus and Esophageal Carcinoma.

Surg Clin North Am 2021 Jun;101(3):381-389

To care and treat patients with esophageal cancer, one must first understand the epidemiology of Barrett's esophagus (BE). BE is defined as the intestinal metaplasia occurring within the esophagus from normal squamous epithelium to abnormal specialized columnar epithelium. BE, while first described by Allison in 1948, was attributed to Norman Barrett in 1950, who reported a case of chronic peptic ulcer in the lower esophagus that was covered by columnar epithelium. Read More

View Article and Full-Text PDF

The Association Between Clopidogrel and Gastrointestinal Bleeding After Primary Total Joint Arthroplasty.

Arthroplast Today 2021 Jun 15;9:61-64. Epub 2021 May 15.

Investigation Conducted at New York University Langone Orthopaedic Hospital, New York, NY, USA.

Background: Anticoagulation after total joint arthroplasty has been demonstrated to reduce venous thromboembolism. However, anticoagulation can lead to adverse bleeding events. The purpose of this study was to assess if an association exists between specific anticoagulation modalities, such as clopidogrel, and postoperative gastrointestinal (GI) bleeding. Read More

View Article and Full-Text PDF

A prospective cohort study of patients presenting to the emergency department with upper gastrointestinal bleeding.

J Family Med Prim Care 2021 Mar 8;10(3):1431-1436. Epub 2021 Apr 8.

Department of Emergency Medicine, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Upper gastrointestinal (UGI) bleeding is a common presentation to the Emergency Department (ED), and is associated with re-bleeding and significant mortality. Although several studies have described etiology and outcome of UGI bleeding, few have been done in the EDs.

Materials And Methods: This prospective observational cohort study included all patients presenting with hematemesis or melena, between June 2016 and January 2017 to the ED. Read More

View Article and Full-Text PDF

Medicinal Plants with Prospective Benefits in the Management of Peptic Ulcer Diseases in Ghana.

Biomed Res Int 2021 5;2021:5574041. Epub 2021 May 5.

Department of Pharmacology and Toxicology, School of Pharmacy, University of Health and Allied Sciences, Private Mail Bag, Volta Region, Ghana.

Background: The growth or multiplication of harmful microorganisms in addition to harmful human activities has led to many disorders in humans. Consequently, there is a search for medications to treat these disorders. Interestingly, medicines of plant origin are known to be among the most attractive sources of new drugs and have shown promising results in the treatment of various diseases including peptic ulcers. Read More

View Article and Full-Text PDF

Seasonal variation of peptic ulcer disease, peptic ulcer bleeding, and acute pancreatitis: A nationwide population-based study using a common data model.

Medicine (Baltimore) 2021 May;100(21):e25820

Department of Internal Medicine, Division of Gastroenterology, Kyung Hee University Hospital at Gang Dong, Seoul, Republic of Korea.

Abstract: Although gastrointestinal diseases are reported at various times throughout the year, some particular seasons are associated with a higher incidence of these diseases. This study aimed to identify the seasonal variations of peptic ulcer (PU), peptic ulcer bleeding (PUB), and acute pancreatitis (AP) in South Korea.We conducted a retrospective, observational cohort study of all subjects aged >18 years between 2012 and 2016 using the Health Insurance Review and Assessment-National Patient Samples database, previously converted to the standardized Observational Medical Outcomes Partnership-Common Data Model. Read More

View Article and Full-Text PDF

The Additive Effect of Platelet-Rich Plasma in the Treatment of Actively Bleeding Peptic Ulcer.

Clin Endosc 2021 May 25. Epub 2021 May 25.

Division of Hepatogastroenterology and Endoscopy, Zagazig University, Zagazig, Egypt.

Background/aims: Peptic ulcer bleeding is the most common cause of upper gastrointestinal tract bleeding. Platelet-rich plasma (PRP) enhances tissue repair, and is therefore used in various medical treatments. A combination of mechanical or electrothermal hemostasis has been recommended for upper gastrointestinal tract bleeding treatment. Read More

View Article and Full-Text PDF

Infections at the nexus of metabolic-associated fatty liver disease.

Arch Toxicol 2021 May 24. Epub 2021 May 24.

Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium.

Metabolic-associated fatty liver disease (MAFLD) is a chronic liver disease that affects about a quarter of the world population. MAFLD encompasses different disease stadia ranging from isolated liver steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis and hepatocellular carcinoma. Although MAFLD is considered as the hepatic manifestation of the metabolic syndrome, multiple concomitant disease-potentiating factors can accelerate disease progression. Read More

View Article and Full-Text PDF