86,249 results match your criteria Peptic Ulcer Disease


Influence of working in auto factory on gastroesophageal reflux disease.

Gastroenterol Hepatol Bed Bench 2018 ;11(Suppl 1):S1-S7

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: Present study aimed to evaluate association between job -related factors and gastroesophageal reflux disease (GERD) among Iranian auto factory's workers.

Background: Many of the gastrointestinal disorders may be caused as the result of stress-related occupations and biorhythm disruption.

Methods: We performed a cross-sectional study on 3590 Iranian Auto factory employees. Read More

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January 2018

Laparoscopic and open repair for perforated duodenal ulcer: single-center experience.

Wideochir Inne Tech Maloinwazyjne 2019 Jan 11;14(1):60-69. Epub 2018 Jun 11.

Department of Surgery 1, Yerevan State Medical University, Yerevan, Armenia.

Introduction: Perforation is a dangerous complication of peptic ulcer disease and requires emergency surgical treatment. In recent decades laparoscopic repair of duodenal perforation has been widely used in emergency abdominal surgery.

Aim: To analyze laparoscopic and open surgical treatment of 120 consecutive patients with perforated duodenal ulcer. Read More

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http://dx.doi.org/10.5114/wiitm.2018.76281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372872PMC
January 2019

Attitude and knowledge of Saudi community pharmacists towards use of proton pump inhibitors.

Saudi Pharm J 2019 Feb 7;27(2):225-228. Epub 2018 Nov 7.

Department of Clinical Pharmacy, King Saud University, Saudi Arabia.

Introduction: Proton pump inhibitors (PPIs) effectively suppress acid secretion and play an important role in peptic ulcer disease and gastroesophageal reflux disease There is a real concern about the overutilization of PPIs, which will lead to significant high cost and undesirable outcomes Despite that most of PPIs are classified as prescribed medications, yet most of their users take them without prescription in Saudi Arabia. Therefore, it was important to understand community pharmacists practice in dealing with PPIs and to evaluate their despising pattern of these medications.

Method: A cross-sectional survey-based study that was carried out between September and December 2017. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362272PMC
February 2019

Effects of Ankaferd Hemostat on Helicobacter pylori strains and antibiotic resistance

Turk J Med Sci 2019 Feb 11;49(1):347-355. Epub 2019 Feb 11.

Background/aim: Ankaferd hemostat (ABS; Ankaferd blood stopper, İstanbul, Turkey) is a folkloric medicinal plant extract. The aim of this study was to determine the effect of Ankaferd hemostat (ABS) on the fate of Helicobacter pylori strains. The study also aims to determine alterations in the antimicrobial resistance of three different H. Read More

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http://dx.doi.org/10.3906/sag-1807-206DOI Listing
February 2019

Machine learning model to predict recurrent ulcer bleeding in patients with history of idiopathic gastroduodenal ulcer bleeding.

Aliment Pharmacol Ther 2019 Feb 13. Epub 2019 Feb 13.

Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.

Background: Patients with a history of Helicobacter pylori-negative idiopathic bleeding ulcers have an increased risk of recurring ulcer complications.

Aim: To build a machine learning model to identify patients at high risk for recurrent ulcer bleeding.

Methods: Data from a retrospective cohort of 22 854 patients (training cohort) diagnosed with peptic ulcer disease in 2007-2016 were analysed to build a model (IPU-ML) to predict recurrent ulcer bleeding. Read More

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http://dx.doi.org/10.1111/apt.15145DOI Listing
February 2019
5.727 Impact Factor

Helicobacter pylori and nutrition: a bidirectional communication.

Minerva Gastroenterol Dietol 2019 Feb 12. Epub 2019 Feb 12.

Unit of Dietetics and Clinical Nutrition, Città della Salute e della Scienza, Turin, Italy.

Helicobacter pylori (HP) is a gram negative flagellated pathogen acid-resistant bacterium; it belongs to the order Campylobacterales that is wide spread all over the world, infecting more than 50% of the world population. HP infection is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and with 3 to 6-fold increased relative risk for developing gastric adenocarcinoma and mucosa-associated lymphoid tissue (MA LT) lymphoma. For this reason HP is recognized by the World Health Organization as a Class I human carcinogen. Read More

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https://www.minervamedica.it/index2.php?show=R08Y9999N00A190
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http://dx.doi.org/10.23736/S1121-421X.19.02568-6DOI Listing
February 2019
1 Read

Risk factors for peptic ulcer disease in patients with end-stage renal disease receiving dialysis.

Kidney Res Clin Pract 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

Background: Compared to the general population, patients with end-stage renal disease have more gastrointestinal symptoms and a higher prevalence of peptic ulcer. Risk factors for peptic ulcer disease in patients with end-stage renal disease, however, remain poorly defined. This study aims to better identify those risk factors. Read More

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http://dx.doi.org/10.23876/j.krcp.18.0060DOI Listing
February 2019

Gastroprotection of Calein D against Ethanol-Induced Gastric Lesions in Mice: Role of Prostaglandins, Nitric Oxide and Sulfhydryls.

Molecules 2019 Feb 11;24(3). Epub 2019 Feb 11.

Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Santo Tomás, Delegación Miguel Hidalgo, Ciudad de México 11340, Mexico.

Peptic ulcers are currently treated with various drugs, all having serious side effects. The aim of this study was to evaluate the gastroprotective activity of calein D (from ), a sesquiterpene lactone with a germacrane skeleton. Gastric lesions were induced in mice by administering ethanol (0. Read More

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http://dx.doi.org/10.3390/molecules24030622DOI Listing
February 2019

Intra- abdominal sepsis from a perforated duodenal ulcer-Management of a difficult surgical abdomen.

Int J Surg Case Rep 2019 Feb 1;55:171-173. Epub 2019 Feb 1.

Department of Surgery, College of Health Sciences, University of Nairobi, Kenya.

Introduction: Peptic ulcer perforation is a common surgical emergency that is a complication of 9% of patients with peptic ulcer disease (Kjetil et al., 2015 [1]). Despite advances in the management of peptic ulcer disease, the number of acute complications have remained constant. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.033DOI Listing
February 2019
1 Read

Rifabutin-Based Rescue Therapy for Eradication: A Long-Term Prospective Study in a Large Cohort of Difficult-to-Treat Patients.

J Clin Med 2019 Feb 6;8(2). Epub 2019 Feb 6.

Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy.

The most commonly used regimens fail to eradicate () infection in 5⁻10% of patients. Those not cured with treatments based on amoxicillin, clarithromycin, nitroimidazoles, fluoroquinolones, bismuth or tetracycline have no other conventional options thereafter. In this prospective long-term monocentric study, patients who failed to eradicate following treatment with all conventional antibiotics were included. Read More

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http://dx.doi.org/10.3390/jcm8020199DOI Listing
February 2019
1 Read

Is the Platelet to Lymphocyte Ratio a Potential Biomarker for Predicting Mortality in Peptic Ulcer Perforation?

Surg Infect (Larchmt) 2019 Feb 8. Epub 2019 Feb 8.

Kirikkale University School of Medicine, Department of General Surgery, Kirikkale, Turkey.

Background: Despite surgical treatment of peptic ulcer perforation (PUP), the high rates of morbidity and mortality have motivated researchers to search for new laboratory markers to predict morbidity and mortality. The aim of this study was to investigate the relation between pre-operative laboratory values and demographic factors and post-operative mortality in patients undergoing surgery for PUP.

Patients And Methods: A retrospective study was made of the clinical findings and laboratory data of patients operated on for a diagnosis of PUP in the general surgery clinic between 2014 and 2018. Read More

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http://dx.doi.org/10.1089/sur.2018.288DOI Listing
February 2019
1 Read

Itch in Psoriasis: A New Look at Well-known Subject.

Acta Derm Venereol 2019 02 8. Epub 2019 Feb 8.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, 50-368 Wroclaw, Poland.

Psoriasis is a chronic inflammatory dermatosis, frequently presenting with chronic itch. This study investigated the prevalence and detailed clinical characteristics of chronic itch in 143 psoriatic patients, with regard to different age groups, comorbidities and pharmacotherapy. Chronic itch was reported by 72% of subjects. Read More

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http://dx.doi.org/10.2340/00015555-3147DOI Listing
February 2019
2 Reads

Transcatheter arterial embolization versus surgery for refractory non-variceal upper gastrointestinal bleeding: a meta-analysis.

World J Emerg Surg 2019 1;14. Epub 2019 Feb 1.

1Emergency Surgery Department, Maggiore Hospital of Parma, University of Parma, Parma, Italy.

Background: Nowadays, very few patients with non-variceal upper gastrointestinal bleeding fail endoscopic hemostasis (refractory NVUGIB). This subset of patients poses a clinical dilemma: should they be operated on or referred to transcatheter arterial embolization (TAE)?

Objectives: To carry out a systematic review of the literature and to perform a meta-analysis of studies that directly compare TAE and surgery in patients with refractory NVUGIB.

Materials And Methods: We searched PubMed, Ovid MEDLINE, and Embase. Read More

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https://wjes.biomedcentral.com/articles/10.1186/s13017-019-0
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http://dx.doi.org/10.1186/s13017-019-0223-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359767PMC
February 2019
4 Reads

Helicobacter pylori infection promotes autophagy through Nrf2-mediated heme oxygenase upregulation in human gastric cancer cells.

Biochem Pharmacol 2019 Feb 4. Epub 2019 Feb 4.

Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul 08826, South Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Sciences and Technology, Seoul National University, Seoul 08826, South Korea; Cancer Research Institute, Seoul National University, Seoul 03080, South Korea. Electronic address:

It has been reported that Helicobacter pylori (H. pylori) infection is one of the primary causes of gastritis and peptic ulcer diseases. More than 50% of the world's population is supposed to be infected by this bacterium. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.02.003DOI Listing
February 2019
1 Read

Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70.

J Basic Clin Physiol Pharmacol 2019 Feb 7. Epub 2019 Feb 7.

Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.

Background Selective serotonin reuptake inhibitors (SSRIs) have recently become potential candidates for a new therapeutic approach to ulcer and gastric bleeding. Heat shock protein 70 (Hsp70) plays an important role in cellular resistance to nonsteroidal anti-inflammatory drugs (NSAIDs). However, there is lack of evidence that fluvoxamine recruits Hsp70 to affect stress-induced gastric ulcer. Read More

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http://dx.doi.org/10.1515/jbcpp-2018-0067DOI Listing
February 2019
1 Read

Magnitude of Helicobacter pylori and associated risk factors among symptomatic patients attending at Jasmin internal medicine and pediatrics specialized private clinic in Addis Ababa city, Ethiopia.

BMC Infect Dis 2019 Feb 6;19(1):118. Epub 2019 Feb 6.

Department of medical laboratory Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: More than 50% of the people are infected worldwide with H. pylori which causes significant public health morbidity and mortality. The distribution is quite different from country to country. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3753-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364427PMC
February 2019
3 Reads

Peptic Ulcer Disease: A Brief Review of Conventional Therapy and Herbal Treatment Options.

J Clin Med 2019 Feb 3;8(2). Epub 2019 Feb 3.

Department of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia.

Peptic ulcer is a chronic disease affecting up to 10% of the world's population. The formation of peptic ulcers depends on the presence of gastric juice pH and the decrease in mucosal defenses. Non-steroidal anti-inflammatory drugs (NSAIDs) and infection are the two major factors disrupting the mucosal resistance to injury. Read More

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http://dx.doi.org/10.3390/jcm8020179DOI Listing
February 2019
2 Reads

Patterns of Co-Occurrence of Chronic Disease Among Older Adults in Tokyo, Japan.

Prev Chronic Dis 2019 01 31;16:E11. Epub 2019 Jan 31.

Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.

Introduction: Multimorbidity, the co-occurrence of 2 or more disorders in a patient, can complicate treatment planning and affect health outcomes. Improvements in prevention and management strategies for patients with 3 or more or more co-occurring chronic diseases requires an understanding of the epidemiology of common 3-way disease patterns and their interactions. Our study aimed to describe these common 3-way disease patterns and examine the factors associated with the co-occurrence of 3 or more diseases in elderly Japanese patients. Read More

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http://dx.doi.org/10.5888/pcd16.180170DOI Listing
January 2019
3 Reads

Evaluation of the efficacy and safety of the hybrid scheme for eradication therapy of Helicobacter pylori infection.

Ter Arkh 2018 Aug;90(8):33-39

A.I. Evdokimov Moscow State Medicine and Dentistry, University of the Ministry of Health of Russia, Moscow, Russia.

Aim: The aim is to conduct a comprehensive comparative study of the efficacy and safety of the hybrid scheme of eradication therapy (ET) in patients with peptic ulcer of the stomach or duodenum associated with Helicobacter pylori.

Materials And Methods: Materials and methods. In a prospective, randomized comparative study, 180 patients were divided into three equal groups of 60 people, depending on the prescribed 10-day ET regimen. Read More

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http://dx.doi.org/10.26442/terarkh201890833-39DOI Listing
August 2018
2 Reads

Efficacy and safety of the use of rebamipide in the scheme of triple eradication therapy of Helicobacter pylori infection: a prospective randomized comparative study.

Ter Arkh 2018 Aug;90(8):27-32

A.I. Evdokimov Moscow State Medicine and Dentistry, University of the Ministry of Health of Russia, Moscow, Russia.

Aim: To evaluate the effectiveness and safety of the use of rebamipide as part of the triple eradication therapy (ET) scheme of Helicobacter pylori infection.

Materials And Methods: A prospective, randomized comparative study included 94 patients with uncomplicated H. pylori-associated stomach / duodenal ulcer. Read More

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http://dx.doi.org/10.26442/terarkh201890827-32DOI Listing
August 2018
1 Read

Gender features of comorbidity in patients with coronary artery disease.

Ter Arkh 2018 Apr;90(4):42-49

Research Institute for Complex Issues of Cardiovascular Disease, Kemerovo, Russia.

Aim: To study the factors associated with high levels of comorbidity in men and women with coronary artery disease (CAD).

Materials And Methods: The data analyzed 742 patients who were screened in the clinic of the research Institute CPSS in 2011, before planned operation coronary artery bypass grafting. All patients were divided into 2 groups: group I - men (n=595; 58 [54; 64] years), group II - women (n=147; 63 [57; 69] years). Read More

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http://dx.doi.org/10.26442/terarkh201890442-49DOI Listing
April 2018
1 Read

Comorbid for gastroduodenal ulcers in the aspect of calcium imbalance and blockers of slow calcium channels in their treatment.

Authors:
L A Fomina

Ter Arkh 2018 Feb;90(2):28-34

Tver State Medical University, Ministry of Health of Russia, Tver, Russia.

Aim: Find out the calcium content of the blood reflecting its balance and functional status the calcium regulatory system when it is comorbid for gastroduodenal ulcers (GDU), developed on the background of chronic erosive gastritis (CEG), chronic erosive duodenitis (CED), arterial hypertension (AH) and osteo-articular pathology with the use of nonsteroidal anti-inflammatory drugs (NSAIDs), and the impact of his changes on the activity ulzerogennogo process, the state of regional microcirculation and the functions of the stomach. To determine the pathogenetic justification for and effectiveness of blockers of slow calcium channels (BSCaC) in complex treatment.

Materials And Methods: Examined 132 patients with GDU. Read More

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http://dx.doi.org/10.26442/terarkh201890228-34DOI Listing
February 2018
1 Read

The Association of Gastritis and Peptic Ulcer With Polymorphisms in the Inflammatory-related Genes IL-4 and IL-10 in Iranian Population.

Iran J Pathol 2018 17;13(2):229-236. Epub 2018 Jul 17.

Dept. of Medical Genetics, Hormozgan University of Medical Science, Bandarabas, Iran.

Background & Objective: The current study aimed at assessing the relationship between gastritis and peptic ulcer susceptibility and inflammation-related gene polymorphisms in Iranian patients.Gastritis and peptic ulcer are common medical complications with serious outcomes on the quality of life. Inflammatory responses of gastric mucosa are associated with helicobacter pylori, but most infected patients remain asymptomatic. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339493PMC
July 2018
1 Read

Intracellular degradation of VacA toxin as a determinant of gastric epithelial cell viability.

Infect Immun 2019 Jan 28. Epub 2019 Jan 28.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA

VacA is a secreted pore-forming toxin that induces cell vacuolation and contributes to the pathogenesis of gastric cancer and peptic ulcer disease. We observed that purified VacA has relatively little effect on the viability of AGS gastric epithelial cells, but the presence of exogenous weak bases such as ammonium chloride (NHCl) enhances the susceptibility of these cells to VacA-induced vacuolation and cell death. Therefore, we tested the hypothesis that NHCl augments VacA toxicity by altering the intracellular trafficking of VacA or inhibiting intracellular VacA degradation. Read More

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http://dx.doi.org/10.1128/IAI.00783-18DOI Listing
January 2019
1 Read

Huge Intramural Duodenal Hematoma Complicated with Obstructive Jaundice following Endoscopic Hemostasis.

Korean J Gastroenterol 2019 Jan;73(1):39-44

Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Intramural hematoma of the duodenum is a relatively unusual complication associated with the endoscopic treatment of bleeding peptic ulcers. Intramural hematomas are typically resolved spontaneously with conservative treatment alone. We report a case of an intramural duodenal hematoma following endoscopic hemostasis with epinephrine injection therapy, which was associated with transient obstructive jaundice in a patient undergoing hemodialysis. Read More

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http://dx.doi.org/10.4166/kjg.2019.73.1.39DOI Listing
January 2019
1 Read

The Association Between Helicobacter Pylori Infection and Liver and Biliary Tract Disorders.

Curr Health Sci J 2018 Apr-Jun;44(2):186-191. Epub 2018 Mar 27.

University of Oradea, Faculty of Medicine and Pharmacy.

Helicobacter Pylori (HP) persistently colonizes the stomach in about 50% of the globe population and it is the main risk factor for peptic ulcer, as well as for gastric adenocarcinoma and MALT gastric lymphoma. The treatment for HP revolutionized the management of the peptic ulcer disease, providing permanent healing in many cases. Preventing colonization of HP would be the primary prevention of gastric malignancy and peptic ulceration. Read More

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http://dx.doi.org/10.12865/CHSJ.44.02.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320469PMC
March 2018
10 Reads

[Association between prescription of long-term systemic glucocorticoid therapy associated measures and prescriber's medical speciality].

Rev Med Interne 2019 Jan 22. Epub 2019 Jan 22.

Service de dermatologie, hôpital Henri-Mondor, 94000 Créteil, France; Équipe d'accueil EA7379 EpiDermE, université Paris-Est Créteil, 94000 Créteil, France.

Introduction: In order to prevent some glucocorticoid-induced adverse events, adjuvant measures are often associated with prescription of long-term (≥3 months) systemic glucocorticoid therapy. The main objective of this study was to study the association between prescription of these measures and the medical specialty of the prescriber.

Methods: A cross-sectional study was conducted through the website www. Read More

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http://dx.doi.org/10.1016/j.revmed.2018.10.388DOI Listing
January 2019
1 Read

Helicobacter pylori vacA, cagA and iceA genotypes in dyspeptic patients from southwestern region, Saudi Arabia: distribution and association with clinical outcomes and histopathological changes.

BMC Gastroenterol 2019 Jan 25;19(1):16. Epub 2019 Jan 25.

Department of Family and Community Medicine, Faculty of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.

Background: The aim of this study was to identify the common H. pylori virulence genes among dyspeptic Southwestern Saudi patients and their association with clinical outcomes and histopathological findings to help practitioners and researchers in the region for better management of infections caused by such bacteria.

Methods: Four hundred two gastric biopsy specimens were analyzed using histopathological examination and real time-PCR. Read More

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http://dx.doi.org/10.1186/s12876-019-0934-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346553PMC
January 2019
3 Reads

Stress ulcer prophylaxis with proton pump inhibitors or histamin-2 receptor antagonists in adult intensive care patients: a systematic review with meta-analysis and trial sequential analysis.

Intensive Care Med 2019 Feb 24;45(2):143-158. Epub 2019 Jan 24.

Centre for Research in Intensive Care, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Purpose: Most intensive care unit (ICU) patients receive stress ulcer prophylaxis. We present updated evidence on the effects of prophylactic proton pump inhibitors (PPIs) or histamine 2 receptor antagonists (H2RAs) versus placebo/no prophylaxis on patient-important outcomes in adult ICU patients.

Methods: We conducted a systematic review with meta-analysis and trial sequential analysis (TSA) of randomised clinical trials assessing the effects of PPI/H2RA versus placebo/no prophylaxis on mortality, gastrointestinal (GI) bleeding, serious adverse events (SAEs), health-related quality of life (HRQoL), myocardial ischemia, pneumonia, and Clostridium (Cl. Read More

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http://dx.doi.org/10.1007/s00134-019-05526-zDOI Listing
February 2019
2 Reads

Efficacy and safety of Syferol-IHP for the treatment of peptic ulcer disease: a pilot, double-blind randomized trial.

Clin Exp Gastroenterol 2019 15;12:21-30. Epub 2019 Jan 15.

Biomedicine Research Group, Nnamdi Azikiwe University, Awka, Nigeria,

Background: To our knowledge, there is no prior randomized study on the utility of Syferol-IHP (blend of virgin coconut oil and oil) when coadministered with a triple therapy schedule.

Aim: This study determined the efficacy and safety of Syferol-IHP as adjunct to conventional triple therapy for the treatment of peptic ulcer disease (PUD).

Methods: A pilot double-blind randomized trial was conducted in patients with confirmed diagnosis (endoscopy-guided biopsy) of PUD. Read More

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https://www.dovepress.com/efficacy-and-safety-of-syferol-ihp
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http://dx.doi.org/10.2147/CEG.S178179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338118PMC
January 2019
3 Reads

BST-104, a Water Extract of Lonicera japonica, Has a Gastroprotective Effect via Antioxidant and Anti-Inflammatory Activities.

J Med Food 2019 Feb 24;22(2):140-151. Epub 2019 Jan 24.

3 Department of Research, GREEN CROSS Wellbeing Co., Ltd., Seongnam, South Korea.

The gastroprotective effects of BST-104 (a water extract of Lonicera japonica) and the mechanisms involved were investigated in murine models of gastritis and peptic ulcer. The gastroprotective effects of BST-104 and its active components were evaluated in rat models of HCl/ethanol-induced gastritis and acetic acid-induced gastric ulcer. After orally administering BST-104, chlorogenic acid, rebamipide (positive control), or vehicle to each animal model, gastric lesion sizes, gastric mucus statuses, proinflammatory cytokine levels, and oxidative stress were measured. Read More

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https://www.liebertpub.com/doi/10.1089/jmf.2018.4231
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http://dx.doi.org/10.1089/jmf.2018.4231DOI Listing
February 2019
3 Reads

Cost-effectiveness analysis of screen-and-treat strategy in asymptomatic Chinese for preventing Helicobacter pylori-associated diseases.

Helicobacter 2019 Jan 22:e12563. Epub 2019 Jan 22.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University, Shanghai, China.

Background: The high prevalence of Helicobacter pylori (H pylori) infection in China results in a substantial public health burden. Medical experts have not agreed on the best solution of population intervention for this problem. We presented a health economic evaluation of a population-based H pylori screen-and-treat strategy for preventing gastric cancer, peptic ulcer disease (PUD), and nonulcer dyspepsia (NUD). Read More

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http://doi.wiley.com/10.1111/hel.12563
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http://dx.doi.org/10.1111/hel.12563DOI Listing
January 2019
4 Reads
4.106 Impact Factor

Usefulness of Ultrasonography in the Diagnosis of Peptic Ulcer Disease in Children.

Pediatr Gastroenterol Hepatol Nutr 2019 Jan 10;22(1):57-62. Epub 2019 Jan 10.

Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Korea.

Purpose: This study was performed to assess the clinical usefulness of transabdominal ultrasonography (TUS) in detecting peptic ulcer disease (PUD) in children.

Methods: Twenty-four patients (19 boys, 5 girls; mean age, 10.6±4. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5223/pghn.2019.2
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http://dx.doi.org/10.5223/pghn.2019.22.1.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333589PMC
January 2019
4 Reads

Predictors of In-Hospital Ambulatory Status Following Low-Energy Hip Fracture Surgery.

Geriatr Orthop Surg Rehabil 2019 10;10:2151459318814825. Epub 2019 Jan 10.

Orthopaedic Trauma Service, Hospital for Special Surgery, New York, NY, USA.

Introduction: Twenty-five percent to seventy-five percent of independent patients do not walk independently after hip fracture (HF), and many patients experience functional loss. Early rehabilitation of functional status is associated with better long-term outcomes; however, predictors of early ambulation after HF have not been well described.

Purposes: To assess the impact of perioperative and patient-specific variables on in-hospital ambulatory status following low-energy HF surgery. Read More

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http://dx.doi.org/10.1177/2151459318814825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328945PMC
January 2019
1 Read

Association of ten gastrointestinal and other medical conditions with positivity to faecal occult blood testing in routine screening: a large prospective study of women in England.

Int J Epidemiol 2019 Jan 21. Epub 2019 Jan 21.

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Background: In 2006, the Bowel Cancer Screening Programme (BCSP) in England began offering biennial faecal occult blood testing (FOBt) at ages 60-69 years. Although FOBt is aimed at detecting colorectal neoplasms, other conditions can affect the result. In a large UK prospective study, we examined associations, both before and after screening, between FOBt positivity and 10 conditions that are often associated with gastrointestinal bleeding. Read More

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http://dx.doi.org/10.1093/ije/dyy271DOI Listing
January 2019
2 Reads

Anti-ulcerogenic activity of dentatin from clausena excavata Burm.f. against ethanol-induced gastric ulcer in rats: Possible role of mucus and anti-oxidant effect.

Phytomedicine 2018 Aug 3;55:31-39. Epub 2018 Aug 3.

Substance Abuse Research Centre, Jazan University, P.O.Box 114, Jazan, Saudi Arabia.

Background: Clausena excavata Burm.f. (Rutaceae) has been used for the treatment of stomach disorders including peptic ulcer. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.06.036DOI Listing
August 2018
3 Reads

Helicobacter pylori infection associated with an increased risk of colorectal adenomatous polyps in the Chinese population.

BMC Gastroenterol 2019 Jan 21;19(1):14. Epub 2019 Jan 21.

Statistical Genomics and Data Analysis Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.

Background: Gastric Helicobacter pylori (H. pylori) is linked with chronic gastritis, peptic ulcer disease, and gastric malignancy. This study aims to investigate the association of gastric H. Read More

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http://dx.doi.org/10.1186/s12876-018-0918-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341657PMC
January 2019
1 Read

Effects of Abdominal Visceral Fat Change on Regression of Erosive Esophagitis.

Authors:
Ji Yong Ahn

Gut Liver 2019 01;13(1):1-2

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.5009/gnl18299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347006PMC
January 2019
1 Read

Changes in serum pepsinogen levels and their value as a predictor of treatment outcomes in children with peptic ulcer.

J Paediatr Child Health 2019 Jan 19. Epub 2019 Jan 19.

Department of Gastroenterology, Wuxi Children's Hospital, Wuxi, China.

Aim: To investigate pepsinogen secretion from the neonatal stage to childhood and its diagnostic value for peptic ulcer (PU) in children.

Methods: In this study, 2114 'healthy' children and 51 children with PUs undergoing a medical examination by gastroscopy were selected as subjects. The serum content of pepsinogen I (PGI) and serum pepsinogen II (PGII) was tested for each of the subjects using time-resolved fluorescence immunoassay, which is characterised by high sensitivity and a wide measuring range. Read More

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http://doi.wiley.com/10.1111/jpc.14365
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http://dx.doi.org/10.1111/jpc.14365DOI Listing
January 2019
4 Reads

Cervical cutaneous sclerosis: the stomach is not far from the skin.

J Eur Acad Dermatol Venereol 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, Assistance Publique - Hôpitaux de Paris, Henri Mondor Hospital, Créteil, France.

Here in, we report a particular case presenting an erythematous and indurated plaque of the neck that has revealed gastric linitis plastic (GLP). An 80-year-old man presented to the Department of Dermatology in November 2015 with a 2-month history of a sclerotic inflammatory infiltration of the skin located on the anterior cervical region (Figure 1a, b) associated with a general impaired condition. Medical history revealed a partial gastrectomy for peptic ulcer 30 years ago. Read More

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http://doi.wiley.com/10.1111/jdv.15432
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http://dx.doi.org/10.1111/jdv.15432DOI Listing
January 2019
5 Reads

A rare case report of fungal esophagitis combined with giant gastric ulcer in an immunocompetent patient.

Medicine (Baltimore) 2019 Jan;98(3):e14158

Department of Digestive Disease, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University.

Rationale: Fungal infection of gastrointestinal (GI) tract is usually seen in immunocompromised patients, but can rarely occur in immunocompetent people in whom no permissive factor is present.

Patient Concerns: We describe a 68-year-old male immunocompetent patient presenting with simultaneous fungal esophagitis and giant gastric ulcer.

Diagnoses: Repeated endoscopic biopsies were taken from the giant gastric ulcer edge and base and histology demonstrated granulation tissue and pseudohyphal fungal forms. Read More

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http://dx.doi.org/10.1097/MD.0000000000014158DOI Listing
January 2019
5 Reads

Replaced gastroduodenal artery with continuation as accessory left hepatic artery: a rare anatomical variant.

CVIR Endovasc 2018 30;1(1):23. Epub 2018 Nov 30.

Department of Interventional Radiology, Staten Island University Hospital, 475 Seaview Ave, Staten Island, NY 10305 USA.

Background: Presented here is a rare case of a gastroduodenal artery (GDA) replaced to the superior mesenteric artery with continuation into an accessory left hepatic artery. To the authors' knowledge, this rare anomaly is not described previously. Replaced GDA is reported, however without continuation into an accessory LHA. Read More

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http://dx.doi.org/10.1186/s42155-018-0032-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319521PMC
November 2018
1 Read

Management of non-variceal upper gastrointestinal bleeding: where are we in 2018?

Frontline Gastroenterol 2019 Jan 9;10(1):35-42. Epub 2018 Feb 9.

Division of Surgery and Interventional Science, University College London, London, UK.

Acute upper gastrointestinal bleeding (AUGIB) is one of the most common medical emergencies in the UK. Despite advancement in technology the management of AUGIB remains a challenge. The clinical community recognise the need for improvement in the treatment of these patients. Read More

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http://fg.bmj.com/lookup/doi/10.1136/flgastro-2017-100901
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http://dx.doi.org/10.1136/flgastro-2017-100901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319149PMC
January 2019
5 Reads

Isolated IgG4-related gastric disease presenting as diffuse gastric wall thickening with ulcer.

J Radiol Case Rep 2018 Sep 30;12(9):9-20. Epub 2018 Sep 30.

Department of Anatomical Pathology, Singapore General Hospital, Singapore.

An 81-year-old male presented with loss of appetite, early satiety and iron deficiency anaemia. A computed tomography (CT) scan of the abdomen and pelvis during initial work-up revealed diffuse gastric mural thickening associated with a large ulcer and adjacent gastro-hepatic lymphadenopathy. The CT appearances, together with the clinical features, were highly suspicious for an infiltrative type of gastric malignancy. Read More

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http://radiologycases.com/index.php/radiologycases/article/v
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http://dx.doi.org/10.3941/jrcr.v12i9.3493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312045PMC
September 2018
6 Reads

The lipoprotein HP1454 of Helicobacter pylori regulates T-cell response by shaping T-cell receptor signalling.

Cell Microbiol 2019 Jan 15:e13006. Epub 2019 Jan 15.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Helicobacter pylori (HP) is a Gram-negative bacterium that chronically infects the stomach of more than 50% of human population and represents a major cause of gastric cancer, gastric lymphoma, gastric autoimmunity, and peptic ulcer. It still remains to be elucidated, which HP virulence factors are important in the development of gastric disorders. Here, we analysed the role of the HP protein HP1454 in the host-pathogen interaction. Read More

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http://dx.doi.org/10.1111/cmi.13006DOI Listing
January 2019
6 Reads
4.915 Impact Factor

Genetic Assessment of Potential Long-Term On-Target Side Effects of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibitors.

Circ Genom Precis Med 2019 Jan;12(1):e002196

Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom (C.P.N., F.Y.L., M.N., S.Y., T.R.W., N.J.S.).

Background: Although short-term trials have suggested that PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors are safe and reduce risk of cardiovascular diseases, their long-term safety is unclear. Genetic variants associated with lower activity of a gene can act as proxies to identify potential long-term side effects of drugs as recently exemplified by association of LDL (low-density lipoprotein)-lowering variants in the HMGCR (target for statins) and PCSK9 genes with increased risk of type 2 diabetes mellitus (T2DM). However, analyses of the full spectrum of potential side effects of PCSK9 inhibition using a genetic approach have not been undertaken. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCGEN.118.002196
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http://dx.doi.org/10.1161/CIRCGEN.118.002196DOI Listing
January 2019
18 Reads

Covered Self-expandable Metallic Stent Insertion as a Rescue Procedure for Postoperative Leakage after Primary Repair of Perforated Duodenal Ulcer.

Korean J Gastroenterol 2018 Nov;72(5):262-266

Division of Gastroenterology, Department of Surgery, National Health Insurance Service Ilsan Hospital, Goyang, Korea.

Surgery has been the standard treatment for perforated duodenal ulcers, with mostly good results. However, the resolution of postoperative leakage after primary repair of perforated duodenal ulcer remains challenging. There are several choices for re-operation required in persistent leakage from perforated duodenal ulcers. Read More

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http://dx.doi.org/10.4166/kjg.2018.72.5.262DOI Listing
November 2018
1 Read

Gout as a Risk Factor for Dry Eye Disease: A Population-Based Cohort Study.

J Clin Med 2019 Jan 9;8(1). Epub 2019 Jan 9.

Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.

This study evaluated the effect of gout on the risk of dry eye disease (DED) by using the National Health Insurance Research Database (NHIRD). Data for 30,192 gout patients (21,081 men and 9111 women) and 30,192 non-gout patients (21,005 men and 9187 women) were analyzed. Approximately 1 million patients were randomly sampled from the NHIRD registry. Read More

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http://www.mdpi.com/2077-0383/8/1/62
Publisher Site
http://dx.doi.org/10.3390/jcm8010062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352280PMC
January 2019
6 Reads