86,408 results match your criteria Peptic Ulcer Disease


Non-malignant Helicobacter pylori-Associated Diseases.

Adv Exp Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany.

Helicobacter pylori infection of the human stomach is associated with chronic gastritis, peptic ulcer disease or gastric carcinoma, and thus a high burden for the public health systems worldwide. Fortunately, only a small subfraction of up to 15-20% of infected individuals will develop serious complications. Unfortunately, it is not always known upfront, who will be affected by serious diesease outcome. Read More

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http://dx.doi.org/10.1007/5584_2019_362DOI Listing

Helicobacter pylori Genetic Polymorphisms in Gastric Disease Development.

Adv Exp Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Infecting half of the world's population, Helicobacter pylori is a medically important bacterium that induces a variety of gastric diseases, including gastritis, peptic ulcer disease, and gastric cancer. Sequencing of almost 1000 H. pylori isolates has revealed a diverse genome that contains abundant polymorphic genetic elements; many of these lie in factors likely to be associated with virulence. Read More

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http://dx.doi.org/10.1007/5584_2019_365DOI Listing

Benign Gastric Ulcer with Epstein-Barr Virus Infection Mimicking Malignant Gastric Ulcer.

Korean J Gastroenterol 2019 Mar;73(3):177-181

, National Police Hospital, Seoul, Korea.

Epstein-Barr virus (EBV) is the cause of infectious mononucleosis, which is characterized by fever, lymphadenopathy, and sore throat. On the other hand, gastrointestinal symptoms of EBV infection like dyspepsia, abdominal pain are non-specific and rarely encountered, which means it is difficult to diagnose gastric involvement of EBV infection without suspicion. The relation between gastric carcinoma and gastric lymphoma associated with EBV infection is well defined, but relations with other EBV-associated gastrointestinal diseases such as gastritis and peptic ulcer disease have rarely been reported. Read More

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http://dx.doi.org/10.4166/kjg.2019.73.3.177DOI Listing

The case series of peritonitis due to perforated peptic ulcer: How does conservative management play role?

Int J Surg Case Rep 2019 Apr 5;58:74-76. Epub 2019 Apr 5.

Department of Surgery, Songkhla Hospital, Muang, Songkhla, 90100, Thailand. Electronic address:

Introduction: Surgical intervention is a conventional treatment for perforated peptic ulcer patients. This study aims to determine whether and how conservative non-operative management plays role in patients with pneumoperitoneum-peritonitis due to perforated peptic ulcers.

Methods: A 9-year retrospective study was conducted in patients, who visit one surgeon service, with peritonitis due to perforated peptic ulcer and received non-operation conservative treatment. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.054DOI Listing

Risks of substance uses, alcohol flush response, Helicobacter pylori infection and upper digestive tract diseases-An endoscopy cross-sectional study.

Kaohsiung J Med Sci 2019 Apr 18. Epub 2019 Apr 18.

Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

This study examines the effects of environmental hazards, including tobacco, alcohol/alcohol flush response, areca nut, and Helicobacter pylori (H pylori) infection on upper digestive diseases. This is a multi-hospital-based endoscopy-survey cross-sectional study. Subjects were received upper endoscopies in outpatient clinics at four hospitals in Taiwan between 2008 and 2013. Read More

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http://dx.doi.org/10.1002/kjm2.12071DOI Listing

Rare Complication of Peptic Ulcer Disease in a Hemopheliac.

Clin Gastroenterol Hepatol 2019 Apr 14. Epub 2019 Apr 14.

Ascension Genesys, Gastroenterology 1 Genesys Parkway, ATTN: Medical Education, Grand Blanc MI 48439.

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http://dx.doi.org/10.1016/j.cgh.2019.04.024DOI Listing
April 2019
1 Read
7.896 Impact Factor

Is tramadol associated to bleeding peptic ulcer? A nationwide case-control study in hospitalized Swedish patients.

PLoS One 2019 17;14(4):e0215356. Epub 2019 Apr 17.

Karolinska Institutet, Department of Clinical Science and Education at Södersjukhuset, Stockholm, Sweden.

Aims: Tramadol, a widely used analgesic drug, inhibits the reuptake of noradrenaline and serotonin impairing the aggregation function of thrombocytes. However, the risk for severe bleeding has previously not been studied. The aim of the present study is to investigate the association between tramadol and bleeding peptic ulcer in the Swedish population. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215356PLOS

Synthesis of β-Ketosulfone Derivatives As New Non-Cytotoxic Urease Inhibitors In Vitro.

Med Chem 2019 Apr 15. Epub 2019 Apr 15.

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270. Pakistan.

Background: Peptic ulcer and urolithiasis are largely due to infection caused by urease producing bacteria. Therefore, discovery of urease inhibitors is an important area of medicinal chemistry research.

Objective: The main goal of the work was to identify novel urease inhibitors with no cytotoxicity. Read More

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http://dx.doi.org/10.2174/1573406415666190415163309DOI Listing
April 2019
4 Reads

Prevalence and Risk Factors of Infection among Children Aged 1 to 15 Years at Holy Innocents Children's Hospital, Mbarara, South Western Uganda.

J Trop Med 2019 7;2019:9303072. Epub 2019 Mar 7.

Mbarara University of Science and Technology, Faculty of Medicine, Department of Medical Laboratory Sciences, P.O. Box 1410, Mbarara, Uganda.

Background: infection affects more than half of the world's population. The infection is generally acquired during childhood but can remain asymptomatic, with long-term clinical sequelae including gastritis, peptic ulcer disease, and stomach cancer.

Methods: The study was approved by Institutional Review Committee of Mbarara University of Science and Technology. Read More

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http://dx.doi.org/10.1155/2019/9303072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431523PMC
March 2019
1 Read

Comparison of Hemospray and Endoclot for the treatment of gastrointestinal bleeding.

World J Gastroenterol 2019 Apr;25(13):1592-1602

Ludwig Demling Endoscopy Center of Excellence, Division of Gastroenterology, Friedrich-Alexander-University, Erlangen 91054, Germany.

Background: Gastrointestinal (GI) bleeding is a common indication for endoscopy. For refractory cases, hemostatic powders (HP) represent "touch-free" agents.

Aim: To analyze short term (ST-within 72 h-) and long-term (LT-within 30 d-) success for achieving hemostasis with HP and to directly compare the two agents Hemospray (HS) and Endoclot (EC). Read More

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https://www.wjgnet.com/1007-9327/full/v25/i13/1592.htm
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http://dx.doi.org/10.3748/wjg.v25.i13.1592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452236PMC
April 2019
3 Reads

Transcatheter arterial embolization versus surgery for uncontrolled peptic ulcer bleeding: game is over.

Quant Imaging Med Surg 2019 Feb;9(2):144-145

Department of Vascular and Interventional Radiology, Image-Guided Therapy Center, François-Mitterrand University Hospital, Dijon Cedex, France.

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http://dx.doi.org/10.21037/qims.2019.02.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414780PMC
February 2019
3 Reads

Investigating the association of proton pump inhibitors with chronic kidney disease and its impact on clinical practice and future research: a review.

Authors:
Ejaz Cheema

J Pharm Policy Pract 2019 29;12. Epub 2019 Mar 29.

Institute of clinical sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT UK.

Background: Proton pump inhibitors (PPIs) are used worldwide for the treatment of gastroesophageal reflux disease (GERD) and peptic ulcer disease (PUD). Although considered to be widely safe, PPIs have been associated with the potential risk of adverse effects such as infections including pneumonia and , malabsorption of vitamins and minerals, dementia and more recently with chronic kidney disease (CKD). Evidence including large cohort studies suggests that there is a greater risk of developing CKD in chronic users of PPIs. Read More

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http://dx.doi.org/10.1186/s40545-019-0167-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440100PMC
March 2019
4 Reads

Association between depression and subsequent peptic ulcer occurrence among older people living alone: A prospective study investigating the role of change in social engagement.

J Psychosom Res 2019 Apr 4. Epub 2019 Apr 4.

Department of Gastroenterology, Shantou University Medical College, PR China. Electronic address:

Objective: To examine whether baseline depression predicts subsequent peptic ulcer disease (PUD) in older people living alone and whether social engagement plays a role in such an association.

Methods: Between May 2010 and May 2015, 2, 850 older people living alone were recruited from eight Grade-A hospitals in the People's Republic of China and followed for up to 36 months. The Kaplan-Meier method was used to investigate how the incidence of PUD varied with depression and social engagement status. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223999183106
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http://dx.doi.org/10.1016/j.jpsychores.2019.04.002DOI Listing
April 2019
3 Reads

Effect of Subjective and Objective Sleep Quality on Subsequent Peptic Ulcer Recurrence in Older Adults.

J Am Geriatr Soc 2019 Apr 11. Epub 2019 Apr 11.

Department of Gastrointestinal Surgery, Shantou University Medical College, Shantou, China.

Objective: To examine the effect of subjective and objective sleep quality on subsequent recurrence of peptic ulcer disease (PUD) among older patients after Helicobacter pylori eradication.

Setting: Eight grade A hospitals in China.

Participants: Of 1689 older Chinese with H. Read More

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http://dx.doi.org/10.1111/jgs.15871DOI Listing
April 2019
1 Read

Long-Term Persistence with Newly-Initiated Warfarin or Non-VKA Oral Anticoagulant (NOAC) in Patients with Non-Valvular Atrial Fibrillation: Insights from the Prospective China-AF Registry.

Med Sci Monit 2019 Apr 11;25:2649-2657. Epub 2019 Apr 11.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, Beijing, China (mainland).

BACKGROUND Oral anticoagulants (OACs) such as warfarin and non-VKA oral anticoagulants (NOACs) have been recommended for patients with atrial fibrillation (AF) who are at risk for stroke. Whether NOACs have a higher persistence than warfarin is still unclear. This is especially true in China. Read More

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http://dx.doi.org/10.12659/MSM.915875DOI Listing
April 2019
3 Reads

A rare case report of gastro-duodenal fourth segment fistula secondary to a penetrating benign gastric ulcer.

J Surg Case Rep 2019 Apr 6;2019(4):rjz096. Epub 2019 Apr 6.

Faculty of Medicine, Tishreen University, Lattakia, Syrian Arab Republic.

A gastro-duodenal fourth segment fistula following a penetrating benign gastric ulcer is extremely rare to be found. To the best of our knowledge, our case is the eighth case to describe the gastro-duodenal third and fourth segment fistula, and it is the third to be diagnosed in living patients as all the other cases were diagnosed in autopsies. The case, we are presenting, is of an elderly patient with severe peptic symptoms and a primary diagnosis of gastric outlet obstruction. Read More

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http://dx.doi.org/10.1093/jscr/rjz096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451182PMC
April 2019
1 Read

Molecular docking of natural phenolic compounds for screening of urease inhibitors.

Curr Pharm Biotechnol 2019 Apr 9. Epub 2019 Apr 9.

International Institute of Pharmaceutical Sciences, Sonepat, Haryana. India.

Bacterial ureases have been the cause of various human and animal pathogenicity including hepatic encephalopathy, hepatic coma urolithiasis, gastric and peptic ulcers, pyelonephritis, and urinary catheter encrustation by production of ammonia. Hence in view of the side effects of existing drugs, there is a strong need to discover, more safe, effective and potent compounds for treatment of infections caused by urease. For this purpose, several natural phenolic compounds have been screened by molecular modelling techniques. Read More

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http://dx.doi.org/10.2174/1389201020666190409110948DOI Listing
April 2019
5 Reads
2.511 Impact Factor

Treatment of Gastrointestinal Symptoms and Mood Disorder With Physical Medicine and Supplementation: A Case Report.

Integr Med (Encinitas) 2018 Jun;17(3):53-58

all affiliated with the National University of Natural Medicine in Portland, Oregon.

This report details the naturopathic treatment of a 28-y-old female with a 1 y history of abdominal pain, heartburn, and constipation as well as longstanding anxiety and depression. Clinical evaluation ruled out organic causes of dyspepsia such as peptic ulcer disease, infection, and nonsteroidal anti-inflammatory drugs-induced dyspepsia. Treatment consisting of soft-tissue manipulation, homeopathic prescription, nutritional supplementation, and lifestyle modification greatly improved gastrointestinal and mental-emotional symptoms after 2 wk. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396765PMC
June 2018
1 Read

Cryo-EM Analysis Reveals Structural Basis of Helicobacter pylori VacA Toxin Oligomerization.

J Mol Biol 2019 Apr 4. Epub 2019 Apr 4.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Helicobacter pylori colonizes the human stomach and contributes to the development of gastric cancer and peptic ulcer disease. H. pylori secretes a pore-forming toxin called vacuolating cytotoxin A (VacA), which contains two domains (p33 and p55) and assembles into oligomeric structures. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.03.029DOI Listing
April 2019
2 Reads

Prevalence of infection in Sari Northern Iran; a population based study.

Gastroenterol Hepatol Bed Bench 2019 ;12(1):31-37

Associate professor, Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran.

Aim: In this study prevalence rate of and its associated factors have been investigated in urban and rural areas of Sari.

Background: has an important role in gastrointestinal diseases including peptic ulcer and gastric cancer. It is the most common infection in human population worldwide. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441486PMC
January 2019
2 Reads

The expression profiling of circulating miR-204, miR-182, and lncRNA H19 as novel potential biomarkers for the progression of peptic ulcer to gastric cancer.

J Cell Biochem 2019 Apr 4. Epub 2019 Apr 4.

Department of Physiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Deregulation of noncoding RNAs, microRNAs (miRNAs) and long noncoding RNA (lncRNA), are implicated in the initiation and progression of gastric cancer (GC). This study is a pilot case-control study carried out on 75 subjects, 40 of them were Helicobacter pylori-gastric ulcer patients and 35 were GC patients recruited from the Gastrointestinal Endoscopy Unit in Al-Kasr Al-Aini Hospital, Cairo University in Egypt. Real-time PCR was performed to evaluate the expression level of serum miR-204, miR-182, and lncRNA H19 in patients with peptic ulcer-progressed GC vs nonprogressed peptic ulcer patients. Read More

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http://dx.doi.org/10.1002/jcb.28620DOI Listing
April 2019
3 Reads

Comorbidities in chronic obstructive pulmonary disease: Results of a national multicenter research project.

Adv Clin Exp Med 2019 Mar;28(3):319-324

Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Poland.

Background: Chronic obstructive pulmonary disease (COPD) is associated with various comorbidities, which influence the course of COPD and worsen prognosis.

Objectives: The aim of this study was to analyze the comorbidities in a cohort of COPD patients in Poland during 12 months of observation.

Material And Methods: A total of 444 COPD patients (median age: 66. Read More

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http://dx.doi.org/10.17219/acem/78024DOI Listing
March 2019
2 Reads

Are Patients with Perforated Peptic Ulcers Who are Negative for Helicobacter pylori at a Greater Risk?

Surg Infect (Larchmt) 2019 Apr 2. Epub 2019 Apr 2.

1 Department of Surgery, Washington University in Saint Louis, Saint Louis, Missouri.

Background: The link between Helicobacter pylori infection and peptic ulceration is well established. Recent studies have reported a decrease of H. pylori-related peptic ulcer disease; Helicobacter pylori eradication is likely the cause of this decrease. Read More

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http://dx.doi.org/10.1089/sur.2018.249DOI Listing
April 2019
6 Reads

[Emergency surgery in Russian Federation (in Russian only)].

Khirurgiia (Mosk) 2019 (3):88-97

Vishnevsky National medical research center of surgery of Ministry of Health of Russia, Moscow, Russia.

In the following article, we present the key trends in emergency surgical care in the Russian Federation between 2000 and 2017. The study used data from federal statistical observations and a survey of state medical institutions in 80 regions encompassing 99.3% of the country's population. Read More

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http://dx.doi.org/10.17116/hirurgia201903188DOI Listing
January 2019
2 Reads

Upper gastrointestinal bleeding in Egyptian patients with cirrhosis: Post-therapeutic outcome and prognostic indicators.

J Gastroenterol Hepatol 2019 Mar 14. Epub 2019 Mar 14.

Hepatology Department, National Liver Institute, University of Menoufia, Shebeen El-Kom, Egypt.

Background And Aim: Upper gastrointestinal bleeding (UGIB) is a serious complication of portal hypertension in cirrhotic patients. The objective of this study is to identify the risk factors for morbidity and mortality occurring after an UGIB attack.

Methods: A total of 1097 UGIB attacks in 690 patients with liver cirrhosis were studied. Read More

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http://dx.doi.org/10.1111/jgh.14659DOI Listing
March 2019
1 Read

Randomized controlled trial of hemostatic powder versus endoscopic clipping for non-variceal upper gastrointestinal bleeding.

Surg Endosc 2019 Mar 29. Epub 2019 Mar 29.

Gastrointestinal Endoscopy Unit, Gastroenterology Department, University of Sao Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, 255. Cerqueira César, São Paulo, 05403-000, Brazil.

Background And Aims: Despite advances in pharmacological and endoscopic management of non-variceal upper gastrointestinal bleeding (NVUGIB), mortality is still relevant. TC-325 (Hemospray-Cook Medical) is a mineral powder with adsorptive properties, designed for endoscopic hemostasis. There are still no comparative trials studying this new hemostatic modality. Read More

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http://dx.doi.org/10.1007/s00464-019-06769-zDOI Listing
March 2019
1 Read

Cytoprotective agent for peptic ulcer prevention in patients taking dual antiplatelet agents: A randomized, double-blind placebo-controlled trial.

J Gastroenterol Hepatol 2019 Mar 28. Epub 2019 Mar 28.

Division of Gastroenterology, Chulalongkorn University and King Chulalongkorn Memorial Hospital The Thai Red Cross, Bangkok, Thailand.

Background: Long-term use of dual antiplatelets is increasing, and most patients need primary peptic ulcer prophylaxis. The long-term use of proton pump inhibitors (PPIs) is associated with adverse events. We evaluated the efficacy of rebamipide for peptic ulcer prevention. Read More

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http://dx.doi.org/10.1111/jgh.14671DOI Listing
March 2019
1 Read

Lansoprazole inhibits the cysteine protease legumain by binding to the active site.

Basic Clin Pharmacol Toxicol 2019 Mar 27. Epub 2019 Mar 27.

Section for Pharmacology and Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway.

Proton pump inhibitors (PPIs) are prodrugs used in the treatment of peptic ulcer diseases. Once activated by acidic pH, the PPIs subsequently inhibit the secretion of gastric acid by covalently forming disulphide bonds with the SH groups of the parietal proton pump, that is the H /K -ATPase. Long-term use of PPIs has been associated with numerous adverse effects, including bone fractures. Read More

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http://dx.doi.org/10.1111/bcpt.13230DOI Listing
March 2019
3 Reads

Antidiabetic Effect of Is Mediated Modulation of Glucose Metabolizing Enzymes, Antioxidant Defenses, and Adiponectin in Type 2 Diabetic Rats.

Authors:
May N Bin-Jumah

Oxid Med Cell Longev 2019 19;2019:6290143. Epub 2019 Feb 19.

Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.

is a succulent bush traditionally used to treat diabetes and peptic ulcer. The present study aimed to investigate the effect of hydroethanolic extract on glucose tolerance, insulin sensitivity, glucose metabolizing enzymes, lipid profile, and adiponectin expression in type 2 diabetic rats. In addition, the study evaluated the antioxidant and anti-inflammatory activities of the extract. Read More

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http://dx.doi.org/10.1155/2019/6290143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399546PMC
April 2019
1 Read

Choledochoduodenal Fistula Secondary to Peptic Ulcer Disease: A Case Report.

Am J Case Rep 2019 Mar 27;20:398-401. Epub 2019 Mar 27.

Department of General Surgery, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon.

BACKGROUND Choledochoduodenal fistula is an uncommon complication secondary to peptic ulcer disease. Determining this diagnosis is challenging especially when confronted with unspecific physical and radiological findings. CASE REPORT Here we report a case of a 29-year-old Ethiopian female who presented to Geitaoui University Hospital in Beirut, Lebanon with epigastric pain and was diagnosed to have of choledochoduodenal fistula. Read More

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http://dx.doi.org/10.12659/AJCR.915600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453551PMC
March 2019
9 Reads

Ethnic Disparities in Gastric Cancer Presentation and Screening Practice in the United States: Analysis of 1997-2010 Surveillance, Epidemiology, and End Results-Medicare Data.

Cancer Epidemiol Biomarkers Prev 2019 Apr 26;28(4):659-665. Epub 2019 Mar 26.

Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona.

Background: Chronic infection with () is the strongest risk factor for distal gastric cancer. Although gastric cancer incidence has decreased, variation by race and ethnicity is observed. This study describes gastric cancer presentation and screening services among Medicare patients by race/ethnicity, place of birth, and history of gastric cancer-related conditions. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0471DOI Listing
April 2019
1 Read

Intestinal Obstruction due to Bezoar in Elderly Patients: Risk Factors and Treatment Results.

Emerg Med Int 2019 17;2019:3647356. Epub 2019 Feb 17.

Istanbul Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Department of General Surgery, Turkey.

Purpose: Bezoars are foreign particles from the accumulation of indigestible materials in the gastrointestinal system and a rare cause of mechanical intestinal obstruction. We aimed at investigating differences in risk factors for the development of intestinal obstruction associated with bezoar in elderly patients.

Methods: Hospital records of patients who underwent surgery associated with phytobezoar between January 2004 and May 2016 were retrospectively evaluated. Read More

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http://dx.doi.org/10.1155/2019/3647356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398050PMC
February 2019
2 Reads

Surgical emergencies in pregnancy in the era of modern diagnostics and treatment.

Taiwan J Obstet Gynecol 2019 Mar;58(2):177-182

R.G.Kar Medical College and Hospital, India.

Pregnancy can be complicated with different surgical emergencies which may potentially endanger the mother as well as foetus. In the modern era of advanced diagnostics and treatments, neither of them in response to a surgical emergency in a pregnant woman should be delayed. Appropriate early intervention is essential to decrease the morbidity and mortality. Read More

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http://dx.doi.org/10.1016/j.tjog.2019.01.001DOI Listing
March 2019
1 Read

Helicobacter pylori: molecular basis for colonization and survival in gastric environment and resistance to antibiotics. A short review.

Infect Dis (Lond) 2019 Mar 25:1-10. Epub 2019 Mar 25.

b Unit of Gastroenterology , Molinette-SGAS Hospital , Turin , Italy.

Helicobacter pylori is a human-specific pathogen with a strict tropism for the gastric mucosa. This bacterium infects around half of the world population and is the main responsible for gastritis, peptic ulcer and, in some cases, for the pathogenesis of gastric cancer. Nevertheless, disease development in infected subjects depends not only on the bacterium, but also on the host genetic predisposition and on environmental factors. Read More

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http://dx.doi.org/10.1080/23744235.2019.1588472DOI Listing
March 2019
3 Reads

The HopQ outermembrane protein inhibits immune cell activities.

Oncoimmunology 2019 29;8(4):e1553487. Epub 2019 Jan 29.

The Institute of Dental Sciences, The Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel.

We previously showed that the colorectal cancer colonizing bacterium protects tumors from immune cell attack via binding of the fusbacterial Fap2 outer-membrane protein to TIGIT, a checkpoint inhibitory receptor expressed on T cells and NK cells. , the causative agent for peptic ulcer disease, is associated with the development of gastric adenocarcinoma and MALT lymphoma. The HopQ outer-membrane adhesin of was recently shown to bind carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) including CEACAM1, an inhibitory receptor expressed mainly by activated T and NK cells. Read More

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http://dx.doi.org/10.1080/2162402X.2018.1553487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422397PMC
January 2019
1 Read

Monopolar hemostatic forceps with soft coagulation: earning a place in the endoscopic hemostasis repertoire for peptic ulcer bleeding.

Gastrointest Endosc 2019 04;89(4):803-805

Department of Surgery, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1016/j.gie.2018.12.006DOI Listing
April 2019
2 Reads

[One case of refractory gout with high fever].

Zhonghua Shao Shang Za Zhi 2019 Mar;35(3):224-227

Skin Wound Repair Center of Department of Burns, Tongren Hospital of Wuhan University & Wuhan Third Hospital, Wuhan 430070, China.

On 17th June 2017, a 50 years old man with refractory gout was admitted in our hospital. During the treatment, he was accompanied by intermittent fever (39 to 40 ℃) of unknown origin for 60 days and gastrointestinal bleeding, with difficult wound repair. After comprehensive treatment of thorough debridement, vacuum sealing drainage, skin graft, skin flap repair, and drug administration, the patient was discharged fully recovered on post hospitalization day 104. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2019.03.012DOI Listing
March 2019
1 Read

Effects of tegoprazan, a novel potassium-competitive acid blocker, on rat models of gastric acid-related disease.

J Pharmacol Exp Ther 2019 Mar 20. Epub 2019 Mar 20.

R&D Institute, CJ HealthCare corp.

Tegoprazan, a novel potassium-competitive acid blocker (P-CAB), is next generation therapeutics in development for acid-related gastrointestinal diseases such as gastroesophageal reflux disease (GERD) and peptic ulcers. In the present study, the in vitro and in vivo pharmacological properties of tegoprazan are compared with those of esomeprazole, a representative proton pump inhibitor. In vitro enzyme assays were performed using the ion-leaky vesicles containing gastric H+/K+-ATPases isolated from porcine. Read More

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http://dx.doi.org/10.1124/jpet.118.254904DOI Listing
March 2019
9 Reads

PREVALENCE OF HELICOBACTER PYLORI INFECTION IN DYSPEPTIC PATIENTS AND ITS ASSOCIATION WITH CLINICAL RISK FACTORS FOR DEVELOPING GASTRIC ADENOCARCINOMA.

Arq Gastroenterol 2019 Mar 18. Epub 2019 Mar 18.

Universidade Federal de Goiás, Faculdade de Farmácia, Goiânia, GO, Brasil.

Background: In Brazil, particularly in the underdeveloped localities, the prevalence of Helicobacter pylori (H. pylori) infections can range up to 90%. These rates are higher in older individuals and vary by country region. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/S0004-2803.201900000-03DOI Listing
March 2019
7 Reads

Prediction Model for Significant Bleeding in Patients with Supratherapeutic International Normalized Ratio After Oral Administration of Warfarin.

Clin Drug Investig 2019 Mar 18. Epub 2019 Mar 18.

Department of Anesthesiology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 77 Goodell Street, Suite 550, Buffalo, NY, 14203, USA.

Background And Objective: The use and range of indications for anticoagulation therapy are steadily growing. The objective of this study was to develop a scoring model to predict the occurrence of significant bleeding in patients taking warfarin with a supra-therapeutic international normalized ratio.

Methods: Data were collected from the medical records of patients taking warfarin with an international normalized ratio > 3. Read More

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http://dx.doi.org/10.1007/s40261-019-00774-9DOI Listing
March 2019
1 Read
1.704 Impact Factor

Increased risk of central serous chorioretinopathy following end-stage renal disease: A nationwide population-based study.

Medicine (Baltimore) 2019 Mar;98(11):e14859

Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan.

This retrospective, nationwide, matched cohort study investigated the risk of central serous chorioretinopathy (CSCR) following end-stage renal disease (ESRD). The study cohort included 84722 ESRD patients who were registered between January 2000 and December 2009 at the Taiwan National Health Insurance Research Database. An age- and sex-matched control group comprised 84722 patients selected from the Taiwan Longitudinal Health Insurance Database 2000. Read More

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http://dx.doi.org/10.1097/MD.0000000000014859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426587PMC
March 2019
7 Reads

Impact of Helicobacter pylori Infection on Gastric Variceal Bleeding among Patients with Liver Cirrhosis.

Gastroenterol Res Pract 2019 10;2019:6529420. Epub 2019 Feb 10.

Tropical Medicine Department, Tanta University, Egypt.

Background And Aims: Currently, it is well known that Helicobacter pylori- (-) related peptic ulcer is one of the main causes of nonvariceal bleeding in cirrhotic patients. However, there is a lack of data to identify the exact effect of infection on variceal bleeding. This study was conducted to identify the impact of infection on gastric variceal bleeding in cirrhotic patients. Read More

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http://dx.doi.org/10.1155/2019/6529420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387698PMC
February 2019
1 Read
1.502 Impact Factor

Genetic basis for metronidazole and clarithromycin resistance in strains isolated from patients with gastroduodenal disorders.

Infect Drug Resist 2019 4;12:535-543. Epub 2019 Mar 4.

Immunology Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: The aim of this study was to evaluate the antimicrobial resistance and genetic basis for metronidazole (Mtz) and clarithromycin (Cla) resistance in strains of , isolated from patients with gastroduodenal disorders.

Patients And Methods: A total of 157 . isolates (from 22 gastric cancer, 38 peptic ulcer disease, and 97 non-ulcer dyspepsia patients) were analyzed for drug susceptibility to Mtz and Cla, by gradient diffusion test (E-test, MAST). Read More

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http://dx.doi.org/10.2147/IDR.S192942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404679PMC
March 2019
4 Reads

A Novel Gastric Spheroid Co-culture Model Reveals Chemokine-Dependent Recruitment of Human Dendritic Cells to the Gastric Epithelium.

Cell Mol Gastroenterol Hepatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Microbiology and Immunology, Montana State University, Bozeman, Montana. Electronic address:

Background & Aims: Gastric dendritic cells (DCs) control the adaptive response to infection with Helicobacter pylori, a major risk factor for peptic ulcer disease and gastric cancer. We hypothesize that DC interactions with the gastric epithelium position gastric DCs for uptake of luminal H pylori and promote DC responses to epithelial-derived mediators. The aim of this study was to determine whether the gastric epithelium actively recruits DCs, using a novel co-culture model of human gastric epithelial spheroids and monocyte-derived DCs. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2019.02.010DOI Listing
March 2019
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Genetic diversity and amino acid sequence polymorphism in Helicobacter pylori CagL hypervariable motif and its association with virulence markers and gastroduodenal diseases.

Cancer Med 2019 Mar 14. Epub 2019 Mar 14.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Genetic variability in cagL gene especially within the Helicobacter pylori CagL hypervariable motif (CagLHM) may affect the development of gastric cancer. Therefore, this study was conducted to investigate the association of CagL diversity with clinical outcomes and with H pylori virulence markers. A total of 126 patients with different gastric diseases including non-ulcer dyspepsia (NUD), peptic ulcer disease (PUD), gastric erosion (GE), and gastric cancer (GC) were enrolled. Read More

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http://dx.doi.org/10.1002/cam4.1941DOI Listing
March 2019
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An evaluation of the epidemiology, management and outcomes for perforated peptic ulcers across the North of England over 15 years: A retrospective cohort study.

Int J Surg 2019 Apr 11;64:24-32. Epub 2019 Mar 11.

Newcastle-Upon-Tyne Hospitals Foundation Trust, United Kingdom.

Background: The management of perforated peptic ulcers has evolved over time and includes laparoscopic or open repair, and conservative management. The utilisation of, and outcomes from these strategies are not clear. Trends in epidemiology, management and outcomes for perforated peptic ulcer across the North of England over a 15-year period were analyzed. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.03.005DOI Listing
April 2019
2 Reads

Application of PCR and Microscopy to Detect in Gastric Biopsy Specimen among Acid Peptic Disorders at Tertiary Care Centre in Eastern Nepal.

Can J Infect Dis Med Microbiol 2019 5;2019:3695307. Epub 2019 Feb 5.

Department of Microbiology, B. P. Koirala Institute of Health Sciences, Dharan, Nepal.

Background: infection is most prevalent in developing countries. It is an etiological agent of peptic ulcer, gastric adenocarcinoma, and mucosal-associated lymphoid tissue (MALT) lymphoma. Despite the development of different assays to confirm infection, the diagnosis of infection is challenged by precision of the applied assay. Read More

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http://dx.doi.org/10.1155/2019/3695307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379864PMC
February 2019
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A Comprehensive Review On the Screening Models for The Pharmacological Assessment of Antiulcer Drugs.

Curr Clin Pharmacol 2019 Mar 12. Epub 2019 Mar 12.

Department Pharmacy, Pranveer Singh Institute of Technology Address: Kanpur - Agra - Delhi National Highway -2, Bhauti, Kanpur, Uttar Pradesh 209305. India.

Background: Due to inappropriate diet, smoking, alcohol consumption, regular use of drugs like NSAIDs, sedentary lifestyle, one may feel upper abdominal pain which may be the predictor of the gastrointestinal disorder called Peptic Ulcer. When an imbalance occurs between the defensive factor and aggressive factor of the stomach, ulcer formation in the esophageal lining, stomach, or duodenum takes place. This leads to the formation of small sores that causes pain. Read More

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http://dx.doi.org/10.2174/1574884714666190312143846DOI Listing
March 2019
1 Read