58,273 results match your criteria Peptic Ulcer Disease


Role of Acid Suppression in Acid-related Diseases: Proton Pump Inhibitor and Potassium-competitive Acid Blocker.

J Neurogastroenterol Motil 2018 Nov 20. Epub 2018 Nov 20.

Fellowship Training Center and Medical Education Center, Keio University School of Medicine, Tokyo, Japan.

Proton pump inhibitors are commonly utilized for the treatment of gastric acid-related conditions, such as gastroesophageal reflux disease, peptic ulcer disease, and infection, and for the prevention of low-dose aspirin or nonsteroidal anti-inflammatory drug associated peptic ulcers. Vonoprazan is a first-in-class potassium-competitive acid blocker, which has distinct advantages compared to other conventional proton pump inhibitors in terms of the rate and effectiveness at which gastric acid suppression occurs. Due to its strong gastric acid suppression capabilities, vonoprazan serves as an effective drug for the treatment of gastroesophageal reflux disease and infection. Read More

View Article
November 2018

Clinical features of Helicobacter pylori antibody-positive junior high school students in Nagano Prefecture, Japan.

Helicobacter 2018 Dec 4:e12559. Epub 2018 Dec 4.

Department of Public Health, Aichi Medical University School of Medicine, Aichi, Japan.

Background: Previously, we conducted an epidemiological study screening for Helicobacter pylori antibody positivity among Japanese junior high school students. In this study, we updated the epidemiological data and assessed the clinical features of H pylori antibody-positive junior high school students.

Materials And Methods: We assessed H pylori antibody-positive subjects who were identified between 2012 and 2015 at four junior high schools in Nagano Prefecture, Japan. Read More

View Article
December 2018

Syntheses, in vitro urease inhibitory activities of urea and thiourea derivatives of tryptamine, their molecular docking and cytotoxic studies.

Bioorg Chem 2018 Nov 1;83:595-610. Epub 2018 Nov 1.

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Dr. Panjwani Centre for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 21412, Saudi Arabia. Electronic address:

Urease is an enzyme of amidohydrolase family and is responsible for the different pathological conditions in the human body including peptic ulcers, catheter encrustation, kidney stone formation, hepatic coma, encephalopathy, and many others. Therefore, the search for potent urease inhibitors has attracted major scientific attention in recent years. Urea and thiourea derivatives of tryptamine (1-25) were synthesized via reaction of tryptamine with different substituted phenyl isocyanates/isothiocyanates. Read More

View Article
November 2018
5 Reads

Trends in Major Gastrectomy for Cancer: Frequency and Outcomes.

J Gastrointest Surg 2018 Dec 3. Epub 2018 Dec 3.

Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 4-3742, Bethesda, MD, 20892, USA.

Background: Declining incidence of gastric cancer in the USA has presumably resulted in lower rates of major gastrectomy for cancer. The impact on perioperative outcomes remains undefined. The aims of this study were to characterize national trends in frequency of major gastrectomy for cancer, identify factors associated with in-hospital mortality, and examine outcome disparities by race/ethnicity. Read More

View Article
December 2018
1 Read

Open surgical treatment of choledochocele: A case report and review of literature.

World J Clin Cases 2018 Nov;6(14):842-846

Department of Biliopancreatic Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.

Choledochocele (also known as type III choledochal cyst according to Todani's classification) is a cystic dilation of the distal segment of the common bile duct protruding into the duodenal lumen. Cases are rare and the etiology remains unclear. It is usually misdiagnosed as peptic ulcer, as in the patient whose case is described here. Read More

View Article
November 2018
2 Reads

Correlation between expression of MMP-9 and MMP-3 in Helicobacter pylori infected patients with different gastroduodenal diseases.

Arab J Gastroenterol 2018 Nov 30. Epub 2018 Nov 30.

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. Electronic address:

Background And Study Aims: Helicobacter pylori (H. pylori) has been implicated in the pathogenesis of most important gastro-duodenal diseases, such as gastritis, peptic ulcer disease (PUD) and gastric cancer. H. Read More

View Article
November 2018

Effect of gastroprotective agents on upper gastrointestinal bleeding in patients receiving direct oral anticoagulants.

Scand J Gastroenterol 2018 Dec 3:1-6. Epub 2018 Dec 3.

b Department of Internal Medicine, Kangdong Sacred Heart Hospital , University of Hallym College of Medicine , Seoul , Republic of Korea.

Objectives: Direct oral anticoagulants (DOACs) are effective in the prevention and treatment of thromboembolism; however, they are associated with upper gastrointestinal bleeding (UGIB). In this study, we evaluated the efficacy of gastroprotective agents (GPAs) in reducing the risk of UGIB in patients receiving DOACs.

Methods: We retrospectively reviewed the medical records of 2076 patients who received DOACs for the prevention or treatment of thromboembolic events between January 2008 and July 2016. Read More

View Article
December 2018

Recent trends in the prevalence of Helicobacter Pylori in symptomatic children: A 12-year retrospective study in a tertiary centre.

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China. Electronic address:

Objective: Helicobacter pylori infection is common among Asians. However, evidence in the recent years has demonstrated a decrease in the prevalence of H. pylori infection among children and adults worldwide. Read More

View Article
November 2018

Roles of Cholesteryl-α-Glucoside Transferase and Cholesteryl Glucosides in Maintenance of Helicobacter pylori Morphology, Cell Wall Integrity, and Resistance to Antibiotics.

MBio 2018 Nov 27;9(6). Epub 2018 Nov 27.

Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad, India

Infection of the human stomach caused by is very common, as the pathogen colonizes more than half of the world's population. It is associated with varied outcomes of infection, such as peptic ulcer disease, gastric ulcers, and mucosa-associated lymphoid tissue lymphoma, and is generally considered a risk factor for the development of gastric adenocarcinoma. Cholesteryl glucosides (CGs) constitute a vital component of the cell wall of and contribute to its pathogenicity and virulence. Read More

View Article
November 2018
1 Read

The Influence of Naproxen on Biological Factors in Leukocyte-Rich Platelet-Rich Plasma: A Prospective Comparative Study.

Arthroscopy 2018 Nov 21. Epub 2018 Nov 21.

Center of Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, U.S.A.; The Steadman Clinic, Vail, Colorado, U.S.A.. Electronic address:

Purpose: To quantify and compare normative catabolic and anabolic factor concentrations in leukocyte-rich platelet-rich plasma (LR-PRP) at various time points, including baseline, 1 week after initiating naproxen use, and after a 1-week washout period.

Methods: Asymptomatic healthy donors aged between 18 and 70 years were recruited (average age, 36.6 years; range, 25-64 years). Read More

View Article
November 2018
3 Reads

Baicalin, Baicalein, and Lactobacillus Rhamnosus JB3 Alleviated Helicobacter pylori Infections in Vitro and in Vivo.

J Food Sci 2018 Dec 23;83(12):3118-3125. Epub 2018 Nov 23.

Dept. of Biological Science and Technology, China Medical Univ., Taichung, 40402, Taiwan.

Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The flavonoid compounds baicalin and baicalein found in many medicinal plants exhibit an anti-inflammatory effect. The administration of Lactobacillus strains reducing the risk of H. Read More

View Article
December 2018
8 Reads

Proton Pump Inhibitors: What the Internist Needs to Know.

Med Clin North Am 2019 Jan 23;103(1):1-14. Epub 2018 Oct 23.

Division of Gastroenterology, Center for Esophageal Diseases, Baylor University Medical Center, Center for Esophageal Research, Baylor Scott & White Research Institute, 3500 Gaston Avenue, 2 Hoblitzelle, Suite 250, Dallas, TX 75246, USA. Electronic address:

This report reviews the physiology of gastric acid suppression by proton pump inhibitors (PPIs) and anti-inflammatory effects of PPIs that are independent of their acid-suppressive effects. Valid indications for PPI use are discussed, as are putative adverse effects of PPIs that have been identified through weak associations in observational studies that cannot establish cause-and-effect relationships. Although evidence supporting the validity of these adverse effects is weak, there is also insufficient evidence to dismiss the risks. Read More

View Article
January 2019
4 Reads

Laparoscopic Repair for Perforated Peptic Ulcer Disease Has Better Outcomes Than Open Repair.

J Gastrointest Surg 2018 Nov 21. Epub 2018 Nov 21.

The Whiteley-Martin Research Centre, Discipline of Surgery, Nepean Hospital, The University of Sydney, Level 5, South Block, P.O. Box 63, Penrith, NSW, 2751, Australia.

Purpose: Over the last 3 decades, laparoscopic procedures have emerged as the standard treatment for many elective and emergency surgical conditions. Despite the increased use of laparoscopic surgery, the role of laparoscopic repair for perforated peptic ulcer remains controversial among general surgeons. The aim of this study was to compare the outcomes of laparoscopic versus open repair for perforated peptic ulcer. Read More

View Article
November 2018
5 Reads

Meta-analysis of risk and protective factors for gastrointestinal bleeding after percutaneous coronary intervention.

Int J Nurs Pract 2018 Nov 19:e12707. Epub 2018 Nov 19.

School of Health Sciences of Wuhan University, Wuhan, China.

Aim: To quantitatively analyse factors related to gastrointestinal bleeding after percutaneous coronary intervention and provide evidence for the prevention of gastrointestinal bleeding.

Data Sources And Review Methods: Cochrane Library, Pubmed, Embase, and Ovid databases were searched from inception to 31 May 2018; case-control and cohort studies published in English were included. The methodological quality of each study was assessed by two independent reviewers using the Newcastle-Ottawa Scale. Read More

View Article
November 2018
2 Reads

Helicobacter pylori evasion strategies of the host innate and adaptive immune responses to survive and develop gastrointestinal diseases.

Microbiol Res 2019 Jan 6;218:49-57. Epub 2018 Oct 6.

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Electronic address:

Helicobacter pylori (H. pylori) is a bacterial pathogen that resides in more than half of the human population and has co-evolved with humans for more than 58,000 years. This bacterium is orally transmitted during childhood and is a key cause of chronic gastritis, peptic ulcers and two malignant cancers including MALT (mucosa-associated lymphoid tissue) lymphoma and adenocarcinoma. Read More

View Article
January 2019
5 Reads

Association of Helicobacter pylori infection with gastroesophageal reflux disease.

J Int Med Res 2018 Nov 19:300060518809871. Epub 2018 Nov 19.

1 Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology; Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology; Wuhan, Hubei Province, China.

Objective: Many studies have shown that Helicobacter pylori ( Hp) is negatively correlated with gastroesophageal reflux disease (GERD). Moreover, some studies deny that eradication of Hp increases the incidence of GERD. Therefore, we investigated the association of Hp infection with GERD. Read More

View Article
November 2018
2 Reads

Gastroduodenal perforation in the pediatric population: a retrospective analysis of 20 cases.

Pediatr Surg Int 2018 Nov 17. Epub 2018 Nov 17.

The Research Institute at Nationwide Children's Hospital, The Ohio State University School of Medicine, 700 Children's Drive, Columbus, OH, 43205, USA.

Objective: The aim of this study was to investigate the pathogenesis, symptoms and individualized surgical management in pediatrics with gastroduodenal perforation (GDP).

Methods: Patients diagnosed with GDP from January 2013 to December 2016 in our hospital were collected and divided into gastric perforation (GP) group and duodenal perforation (DP) group. Demographics, clinical events, etiological factors, symptoms, the time from symptom onset to operation, intraoperative findings and surgical procedures were analyzed. Read More

View Article
November 2018
6 Reads

Risk of Rebleeding After Hemostasis for Peptic Ulcer.

Dig Dis Sci 2018 Nov 16. Epub 2018 Nov 16.

National Mycobacterial Reference Unit National Mycobacterium Reference Laboratory (NMRL) Abernethy Building, Institute of Cell and Molecular Science (ICMS), 2 Newark Street, London, E1 2AT, UK.

View Article
November 2018

Association of gastric and duodenal ulcers with anthropometry and nutrients: Korean National Health and Nutrition Examination Survey (KNHANES II-IV) 2001-2009.

PLoS One 2018 15;13(11):e0207373. Epub 2018 Nov 15.

Future Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.

Objectives: The objective of this study was to examine the association of peptic ulcer disease (PUD), including gastric ulcer and duodenal ulcer, with obesity-related indices, nutrients, and blood parameters in Korean adults.

Methods: Data were obtained from the Second-Fourth Korean National Health and Nutrition Examination Survey (KNHANES II-IV). Binary logistic regression was carried out to analyze the association between PUD and all variables in the crude analysis; in a subsequent analysis, adjustments were made for age, region, house type, number of snacks per day, and number of household members. Read More

View Article
November 2018
4 Reads
3.230 Impact Factor

Helicobacter pylori infection and prevalence of stroke.

Helicobacter 2018 Nov 15:e12553. Epub 2018 Nov 15.

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Helicobacter pylori causes peptic ulcer disease; however, conflicting evidence exists regarding its role in extragastric conditions. We aimed to examine associations of H pylori infection and peptic ulcer disease with stroke.

Methods: A cross-sectional study was undertaken using data of 147 936 individuals aged 25-95 years who underwent the urea breath test during 2002-2012, based on the computerized database of the second largest health maintenance organization in Israel. Read More

View Article
November 2018
1 Read

Management of perforated duodenal peptic ulcer treated by suture.

Tunis Med 2018 Jul;96(7):424-429

Background: Laparoscopic surgery has become the gold standard for many procedures owing to its advantages such as a shorter post-operative stay, a faster recovery and less postoperative pain. However, choosing laparoscopic approach in an emergency situationsuch as in the management of a perforated duodenal peptic ulcer is still debated because of the absence of significant benefits. This study aimed to assess the management of perforated duodenal peptic ulcer treated by suture. Read More

View Article
July 2018
9 Reads

Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru.

BMC Res Notes 2018 Nov 14;11(1):809. Epub 2018 Nov 14.

Barcelona Research Center for Multiscale Science and Engineering, Departament d'Enginyeria Química, EEBE, Universidad Politecnica de Catalunya (UPC), Barcelona Tech, Barcelona, Spain.

Objective: The objective of this study was to determine the prevalence of clarithromycin-resistant Helicobacter pylori in asymptomatic children in a rural community of Cajamarca (northern Peru).

Results: Helicobacter pylori was detected in 17.2% (49/285) of the samples. Read More

View Article
November 2018
1 Read

Designing a novel ELISA method based on recombinant antigens to increase sensitivity and specificity of whole cell antigen detection.

Gastroenterol Hepatol Bed Bench 2018 ;11(4):333-342

Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Aim: In this research, we designed a direct Enzyme Linked Immunoassay method to detect antigens in stool specimens.

Background: infection as the worldwide problem is related to many gastrointestinal disorders such as gastritis, gastric cancer, non-ulcer disease, peptic ulcer disease and duodenal ulcer.

Methods: We produced and purified recombinant and antigens in and extracted their antibodies from a panel of positive sera specimens. Read More

View Article
January 2018
10 Reads

Evaluation of anti-ulcer and ulcerative colitis of L.

Saudi Pharm J 2018 Nov 12;26(7):956-959. Epub 2018 May 12.

Pharmacognosy Department, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

L. was evaluated for its gastro antiulcerogenic and anti-ulcerative colitis activities Different extracts and fractions from aerial parts and roots were evaluated at different dose; total alcohol extracts of aerial parts SA and roots SR were evaluated doses 250 & 500 mg/kg, While Successive extracts (SAL, SRL, CSA, CSR, BSA & BSR) were evaluated at dose of 150 mg/kg. Absolute ethanol-induced ulcer model was used for evaluation of the anti-ulcerogenic activity. Read More

View Article
November 2018
2 Reads

Increased risk of peptic ulcer in patients with early-onset cataracts: A nationwide population-based study.

PLoS One 2018 9;13(11):e0207193. Epub 2018 Nov 9.

Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan.

Early-onset cataracts (EOC) are associated with an increased inflammatory response; therefore, a potential risk of other inflammatory diseases, like peptic ulcer, may be related. This study investigated the risk of peptic ulcer after being diagnosed with EOC. Retrospective claims data from the Taiwan National Health Insurance Research Database were analyzed. Read More

View Article
November 2018
3 Reads

Recruitment of CCR6 Foxp3 regulatory gastric infiltrating lymphocytes in Helicobacter pylori gastritis.

Helicobacter 2018 Nov 9:e12550. Epub 2018 Nov 9.

Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.

Helicobacter pylori (H. pylori) infection is associated with an inflammatory response in the gastric mucosa, leading to chronic gastritis, peptic ulcers, and gastric cancer. Increased T-cell infiltration is found at sites of H. Read More

View Article
November 2018
6 Reads

Efficacy of duodenal bulb biopsy for diagnosis of celiac disease: a systematic review and meta-analysis.

Endosc Int Open 2018 Nov 7;6(11):E1369-E1378. Epub 2018 Nov 7.

Division of Gastroenterology and Hepatology, University of New Mexico, Albuquerque, New Mexico, United States.

Although duodenal biopsy is considered the "gold standard" for diagnosis of celiac disease, the optimal location of biopsy within the small bowel for diagnosis remains unclear. The primary aim of this study was to perform a structured systematic review and meta-analysis to evaluate the diagnostic utility of endoscopic duodenal bulb biopsy for celiac disease. Searches of PubMed, EMBASE, Web of Science, and Cochrane Library databases were performed from 2000 through December 2017. Read More

View Article
November 2018
1 Read

Non-pharmacological interventions to combat exercise-induced muscle damage, a little natural tax on work out.

J Pak Med Assoc 2018 Nov;68(11):1686-1690

Sargodha Medical College, University of Sargodha, Sargodha, Pakistan.

Debilitating pain, stiffness, tenderness, fatigue, impaired muscle function, lack of strength subsequent to exercise are not welcomed by those not accustomed to it. It may discourage an individual from participating in regular exercise. Numerou s ph armacological and non - pharmacological strategies have been used to alleviate symptoms of muscle soreness, muscle pain, improving muscle function, the range of motion and recovery time. Read More

View Article
November 2018
3 Reads

Helicobacter pylori increases the risk of low-dose aspirin ulcers: A meta-analysis.

J Gastroenterol Hepatol 2018 Nov 8. Epub 2018 Nov 8.

Melbourne School of Medicine, University of Melbourne, Parkville, Victoria, Australia.

Background And Aim: Owing to wide-spread use, low-dose aspirin (LDA) produces a substantial amount of peptic ulcer disease. Current guidelines are ambivalent about the need for Helicobacter pylori eradication to protect against LDA ulcers. This study aimed to determine, through meta-analysis, if (and by how much) infection alters the baseline risk of peptic ulcers during LDA therapy. Read More

View Article
November 2018
4 Reads

Polymorphisms in the host CYP2C19 gene and antibiotic-resistance attributes of Helicobacter pylori isolates influence the outcome of triple therapy.

J Antimicrob Chemother 2018 Nov 6. Epub 2018 Nov 6.

Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Objectives: Eradication of Helicobacter pylori is influenced by susceptibility to antimicrobial agents, elevated bacterial load and degree of acid inhibition, which can be affected by genotypes of drug-metabolizing enzymes [cytochrome P450 (CYP) 2C19 polymorphism]. Theoretically, the choice and dose of proton pump inhibitor may also influence the suppression of H. pylori infection. Read More

View Article
November 2018
9 Reads
5.313 Impact Factor

Changing Disease Trends in the Northern Gyeonggi-do Province of South Korea from 2002 to 2013: A Big Data Study Using National Health Information Database Cohort.

Osong Public Health Res Perspect 2018 Oct;9(5):248-254

Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Objectives: To investigate the chronological patterns of diseases in Northern Gyeonggi-do province, South Korea, and compare these with national data.

Methods: A National Health Insurance cohort based on the National Health Information Database (NHID Cohort 2002-2013) was used to perform a retrospective, population-based study (46,605,433 of the target population, of which 1,025,340 were randomly sampled) to identify disease patterns from 2002 to 2013. Common diseases including malaria, cancer (uterine cervix, urinary bladder, colon), diabetes mellitus, psychiatric disorders, hypertension, intracranial hemorrhage, bronchitis/bronchiolitis, peptic ulcer, and end stage renal disease were evaluated. Read More

View Article
October 2018
3 Reads

Is There a Reason for the Proton Pump Inhibitor? An Assessment of Prescribing for Residential Care Patients in British Columbia.

Can J Hosp Pharm 2018 Sep-Oct;71(5):295-301. Epub 2018 Oct 31.

, BSc(Pharm), PharmD, is with Lower Mainland Pharmacy Services, Surrey British Columbia, and the Therapeutics Initiative (The University of British Columbia), Vancouver, British Columbia.

Background: The use of proton pump inhibitors (PPIs) may cause significant harm to patients in the residential care setting, as these patients are often frail with multiple morbidities. The extent of non-evidence-based use of PPIs in residential care sites of the Fraser Health Authority in British Columbia is unknown.

Objective: To determine the proportion of non-evidence-based use of PPI therapy for residential care patients of the Fraser Health Authority. Read More

View Article
October 2018
4 Reads

Assessment of endoscopic Doppler to guide hemostasis in high risk peptic ulcer bleeding.

Scand J Gastroenterol 2018 Nov 5:1-8. Epub 2018 Nov 5.

a Clinic for Internal Medicine IV (Gastroenterology, Hepatology and Infectious Diseases) , Jena University Hospital , Jena , Germany.

Introduction: Rebleeding or emergency surgery in failed endoscopic therapy of peptic ulcer bleeding are associated with high rates of morbidity and mortality. The clinical benefit of an endoscopic Doppler (ED) examination prior to endoscopic injection therapy was evaluated in high risk ulcer patients for rebleeding episode. Standard injection therapy (non-Doppler (ND)) was compared with targeted injection therapy after examination of the supplying vessel in the ulcer base by the ED. Read More

View Article
November 2018
5 Reads

[Gastroesophageal reflux disease is associated with high risk of obstructive sleep apnea syndrome].

Zhonghua Nei Ke Za Zhi 2018 Nov;57(11):824-829

Department of Gastroenterology, The Central Hospital of Longhua District, Shenzhen 518110, China.

To investigate the relationship between gastroesophageal reflux disease (GERD) and obstructive sleep apnea syndrome(OSAS). Patients diagnosed as GERD and healthy controls without GERD related symptoms or endoscopic esophagitis were enrolled from October 2017 and December 2017. All subjects completed Berlin Questionaire to assess the risk of OSAS. Read More

View Article
November 2018
4 Reads

The Impacts of Peptic Ulcer on Functional Outcomes of Ischemic Stroke.

J Stroke Cerebrovasc Dis 2018 Oct 31. Epub 2018 Oct 31.

Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, Jiangsu, China; Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China. Electronic address:

Background And Purpose: Studies have shown that peptic ulcer increased the risk of ischemic stroke and stroke recurrence. This study aimed to evaluate the impacts of peptic ulcer on functional outcomes of ischemic stroke.

Methods: Patients with first-ever ischemic stroke were grouped as with and without history of peptic ulcer. Read More

View Article
October 2018
4 Reads

Cardiovascular and non-cardiovascular concerns with proton pump inhibitors: Are they safe?

Trends Cardiovasc Med 2018 Oct 21. Epub 2018 Oct 21.

Italian National Research Center on Aging (IRCCS INRCA), Ancona, Cosenza, Italy.

The introduction of proton pump inhibitors (PPIs) has been a cornerstone in the treatment of acid-related disorders, such as gastroesophageal reflux and peptic ulcer, and their use has increased rapidly during the last decades. Being highly lipophilic drugs, they may potentially affect several pathophysiological pathways involved in cardiovascular and kidney morbidity, immune response and infections, absorption of selected nutrients, bone metabolism and cognitive function. Clinical epidemiology evidence coming from well-designed analyses of observational data consistently reported that long-term use of PPIs may increase the risk of cardiovascular events among patients treated with thienopyridines, tubular-interstitial nephritis and chronic kidney disease, hypomagnesemia, and fractures. Read More

View Article
October 2018
8 Reads

High-frequency miniprobe endoscopic ultrasonography for evaluation of indeterminate esophageal strictures.

Ann Gastroenterol 2018 Nov-Dec;31(6):680-684. Epub 2018 Sep 14.

Department of Surgery (Rajesh Gupta), Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Background: Patients with esophageal stricture who have normal mucosa and whose endoscopic biopsies are inconclusive pose a difficult diagnostic dilemma. We prospectively assessed high-frequency miniprobe endoscopic ultrasonography (EUS) for the evaluation of indeterminate esophageal strictures.

Methods: Over a period of 3 years, 19 patients (14 male; mean age: 58. Read More

View Article
September 2018
1 Read

Pediatric Gastritis, Gastropathy, and Peptic Ulcer Disease.

Pediatr Rev 2018 Nov;39(11):542-549

Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Nicklaus Children's Hospital, Miami, FL.

View Article
November 2018
2 Reads

ACVIM consensus statement: Support for rational administration of gastrointestinal protectants to dogs and cats.

J Vet Intern Med 2018 Nov 31;32(6):1823-1840. Epub 2018 Oct 31.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Texas A & M University, College Station, Texas.

The gastrointestinal (GI) mucosal barrier is continuously exposed to noxious toxins, reactive oxygen species, microbes, and drugs, leading to the development of inflammatory, erosive, and ultimately ulcerative lesions. This report offers a consensus opinion on the rational administration of GI protectants to dogs and cats, with an emphasis on proton pump inhibitors (PPIs), histamine type-2 receptor antagonists (H RAs), misoprostol, and sucralfate. These medications decrease gastric acidity or promote mucosal protective mechanisms, transforming the management of dyspepsia, peptic ulceration, and gastroesophageal reflux disease. Read More

View Article
November 2018
7 Reads

High-Resolution HDX-MS of Cytochrome c Using Pepsin/Fungal Protease Type XIII Mixed Bed Column.

J Am Soc Mass Spectrom 2018 Oct 29. Epub 2018 Oct 29.

Thermo Fisher Scientific, 355 River Oaks Parkway, San Jose, CA, 95134, USA.

A pepsin/FPXIII (protease from Aspergillus saitoi, type XIII) mixed bed column significantly improved the resolution of bottom-up hydrogen/deuterium exchange mass spectrometry (HDX-MS) data compared with a pepsin-only column. The HDX-MS method using the mixed bed column determined 65 amide hydrogen exchange rates out of one hundred cytochrome c backbone amide hydrogens. Different cleavage specificities of the two enzymes generated 138 unique high-quality peptic fragments, which allows fine sub-localization of deuterium. Read More

View Article
October 2018
4 Reads

Efficacy of compound tablets combined with quadruple therapy for eradication and its correlation with pH value in the stomach: a study protocol of a randomised, assessor-blinded, single-centre study.

BMJ Open 2018 Oct 28;8(10):e023131. Epub 2018 Oct 28.

Department of Gastroenterology, Chongqing University Cancer Hospital &Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, China.

Introduction: (Hp) is an important pathogenic factor for chronic gastritis, peptic ulcer, gastric cancer, gastric mucosa-associated lymphoid tissue lymphoma and other diseases. In China, the Hp infection rate is high, but the eradication rate is decreasing. A large number of literatures have shown that the addition of can improve the Hp eradication rate and reduce the side effects of antibiotic treatments. Read More

View Article
October 2018
5 Reads

Expression levels of A disintegrin and metalloproteases (ADAMs), and Th17-related cytokines and their association with Helicobacter pylori infection in patients with gastroduodenal diseases.

Pathog Dis 2018 Nov 1;76(8). Epub 2018 Nov 1.

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow (U.P.) 226014, India.

Expression levels of A disintegrin and metalloproteases (ADAMs) (10 and 17) and Th17-related cytokines [interleukin (IL) 17A, IL-17F, IL-33, IL-23, IL-23R] were investigated by quantitative real time polymerase chain reaction in gastric biopsies of patients with different gastroduodenal pathologies in the presence and absence of Helicobacter pylori infection. Patients with gastric cancer (GC) (n = 70, intestinal-type 38 and diffuse type 32), peptic ulcer disease [n = 50, duodenal ulcer (DU) 16 and gastric ulcer (GU) 34] and functional dyspepsia (n = 120) were included in the study. Further, the expression levels of ADAMs and Th17 cytokines were correlated with H. Read More

View Article
November 2018
4 Reads

Risk factors for upper gastrointestinal bleeding among aspirin users: An old issue with new findings from a population-based cohort study.

J Formos Med Assoc 2018 Oct 23. Epub 2018 Oct 23.

Department of Medicine, National Yang-Ming University, School of Medicine, Taipei, Taiwan; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Background/purpose: We aimed to identify the risk factors of first-time occurrence of non-variceal upper gastrointestinal bleeding (UGIB) among aspirin users after adjusting for confounding factors like age, gender, underlying co-morbidities, and medications.

Methods: Using the National Health Insurance Research Database of Taiwan and matching age, gender, underlying co-morbidities and enrollment time by propensity score, 11105 aspirin users and 11105 controls were identified for comparison from a cohort dataset of 1,000,000 randomly sampled subjects. Cox proportional hazard regression models were used to identify independent risk factors for first-time occurrence of non-variceal UGIB in the study cohort and in the aspirin users after adjusting for age, gender, underlying co-morbidities, and medications (e. Read More

View Article
October 2018
8 Reads

Cumulative exposure to nighttime environmental noise and the incidence of peptic ulcer.

Environ Int 2018 Dec 24;121(Pt 2):1172-1178. Epub 2018 Oct 24.

Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea. Electronic address:

Background: Exposure to noise poses auditory and non-auditory effects on health. The gastrointestinal tract is considered as the site of adverse reactions to noise-induced stress; little attention has been paid to a potential link between noise and peptic ulcers.

Objectives: The aim of this study was to investigate whether cumulative exposure to environmental noise affects the incidence of peptic ulcer in adults. Read More

View Article
December 2018
1 Read

Gastrocolic Fistula: A Rare Presentation of Colon Cancer.

Case Rep Gastrointest Med 2018 1;2018:6958925. Epub 2018 Oct 1.

Division of Gastroenterology, Bronx Care Health System-Affiliate of Mount Sinai Hospital System, New York, USA.

Gastrocolic fistulae have been described for benign conditions including penetrating peptic ulcer and complicated pancreatitis. Malignant etiology can arise from gastric or colon cancer and is a rare and late complication with an incidence of 0.3-0. Read More

View Article
October 2018
3 Reads

Incidence and Outcomes of Perforated Peptic Ulcers in Children: Analysis of the Kid's Inpatient Database and Report of Two Cases Treated by Laparoscopic Omental Patch Repair.

J Laparoendosc Adv Surg Tech A 2018 Oct 23. Epub 2018 Oct 23.

1 Division of Pediatric Surgery, Department of Surgery, Saint Louis University School of Medicine , Saint Louis, Missouri.

Introduction: Peptic ulcer disease (PUD) is a rare condition in children. Perforated peptic ulcer (PPU), a complication of PUD has an estimated mortality between 1.3% and 20%. Read More

View Article
October 2018
1 Read

Comorbidity profiles among patients with recurrent aphthous stomatitis: A case-control study.

J Formos Med Assoc 2018 Oct 19. Epub 2018 Oct 19.

Institute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai, China; Department of Radiation Oncology, Wanfang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Background/purpose: Recurrent aphthous stomatitis (RAS) is common and associated with certain comorbidities. The aim of this study was to investigate the prevalence of selected comorbidities in patients with RAUs and to compare the risks of comorbidity between the two cohorts of patients with or without RAUs based on the Taiwanese National Health Insurance Research Database.

Methods: This case-control study included patients with recurrent aphthous stomatitis (the RAS cohort) and patients without recurrent aphthous stomatitis using 1:1 matching for year of index date, age, sex, monthly income, geographical location, and urbanization level (the non-RAS cohort). Read More

View Article
October 2018
1 Read

Diagnosis of Infection in Children and Adolescents in Korea.

Pediatr Gastroenterol Hepatol Nutr 2018 Oct 10;21(4):219-233. Epub 2018 Oct 10.

Department of Pediatrics, Gyeongsang National Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju, Korea.

plays an important role in the pathogenesis of chronic gastritis, peptic ulcer disease, gastric cancer, and gastric mucosa-associated lymphoid tissue lymphoma. In Korea, the guidelines for the diagnosis and treatment of infection in adults were revised in 2013. The European Helicobacter and Microbiota Study Group and Consensus panel released the fifth edition of the Maastricht Consensus Report for the management of infection in 2015, and the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the North American Society of Paediatric Gastroenterology, Hepatology and Nutrition released the updated joint guidelines for children and adolescents in 2016. Read More

View Article
October 2018
1 Read