87,301 results match your criteria Peptic Ulcer Disease


Helicobacter pylori patient isolates from South Africa and Nigeria differ in virulence factor pathogenicity profile and associated gastric disease outcome.

Sci Rep 2020 Jul 10;10(1):11409. Epub 2020 Jul 10.

Chair of Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer-Institute, Faculty of Medicine, LMU Munich, Munich, Germany.

Helicobacter pylori is a gram-negative, spiral-shaped bacterial pathogen and the causative agent for gastritis, peptic ulcer disease and classified as a WHO class I carcinogen. While the prevalence of H. pylori infections in Africa is among the highest in the world, the incidence of gastric cancer is comparably low. Read More

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http://dx.doi.org/10.1038/s41598-020-66128-0DOI Listing

Delayed Management of Zollinger-Ellison Syndrome in a Noncompliant Patient.

Cureus 2020 Jun 6;12(6):e8471. Epub 2020 Jun 6.

Department of Gastroenterology and Hepatology, Carol Davila University of Medicine and Pharmacy, Floreasca Emergency Hospital, Bucharest, ROU.

We present a case of a 60-year-old male diagnosed with Zollinger-Ellison syndrome (ZES) after a protracted multicentric workup for chronic diarrhea and unexplained weight loss. ZES is intrinsically difficult to diagnose due to nonspecific symptoms, which are mimicked by other more frequent pathologies, such as peptic ulcer disease secondary to Helicobacter pylori or nonsteroidal anti-inflammatory drugs. The diagnostic challenge can be further complicated by patient noncompliance, resulting in delayed management and unnecessary health care. Read More

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http://dx.doi.org/10.7759/cureus.8471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336717PMC

Optimized Ellagic Acid-Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats.

Biomolecules 2020 Jul 6;10(7). Epub 2020 Jul 6.

Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

A peptic ulcer is an alimentary tract injury that leads to a mucosal defect reaching the submucosa. This work aimed to optimize and maximize ellagic acid (EA) loading in Ca pectinate floating beads to maximize the release for 24 h. Three factors were selected: Ca pectinate concentration (X1, 1-3 w/v %), EA concentration (X2, 1-3 w/v %) and the dropping time (X3, 10-30 min). Read More

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http://dx.doi.org/10.3390/biom10071006DOI Listing

Refining prediction of major bleeding on antiplatelet treatment after transient ischaemic attack or ischaemic stroke.

Eur Stroke J 2020 Jun 19;5(2):130-137. Epub 2020 Jan 19.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, the Netherlands.

Introduction: Bleeding is the main safety concern of treatment with antiplatelet drugs. We aimed to refine prediction of major bleeding on antiplatelet treatment after a transient ischaemic attack (TIA) or stroke by assessing the added value of new predictors to the existing STOP-BLEED score.

Patients And Methods: We used Cox regression analysis to study the association between candidate predictors and major bleeding among 2072 patients with a transient ischaemic attack or ischaemic stroke included in a population-based study (Oxford Vascular Study - OXVASC). Read More

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http://dx.doi.org/10.1177/2396987319898064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309362PMC

Phytochemical and Antiulcer Activity Screening of Seed Extract of Lam (Boraginaceae) in Pyloric Ligated Rats.

Clin Pharmacol 2020 26;12:67-73. Epub 2020 Jun 26.

Bahir Dar University, College of Medicine and Health Science, School of Health Science, Bahir Dar, Ethiopia.

Introduction: Peptic ulcer disease represents a worldwide health problem because of its high morbidity, mortality and economic loss. It is a very prevalent condition affecting around 10%-15% of the general population worldwide. Most of the available antiulcer drugs are costly and have an incidence of relapse, drug interactions and several side effects upon chronic usage. Read More

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http://dx.doi.org/10.2147/CPAA.S245672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326687PMC

Neratinib-Induced Duodenal Ulcer: A Case Report.

Breast Cancer (Auckl) 2020 23;14:1178223420935871. Epub 2020 Jun 23.

Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA.

We report a case of a 37-year-old woman who developed a duodenal ulcer while receiving adjuvant neratinib for HER2 positive breast cancer. The clinical course of abdominal pain was strongly correlated with the use of neratinib. An esophagogastroduodenoscopy (EGD) was performed and confirmed the diagnosis of a large duodenal ulcer. Read More

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http://dx.doi.org/10.1177/1178223420935871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315670PMC

The Use of C-Urea Breath Test for Non-Invasive Diagnosis of Infection in Comparison to Endoscopy and Stool Antigen Test.

Diagnostics (Basel) 2020 Jul 3;10(7). Epub 2020 Jul 3.

Deapartment of Pathology, Microbiology and Forensic Medicine, Jordan University, Amman 11924, Jordan.

() can cause gastritis, peptic ulcer diseases and gastric carcinoma. Endoscopy as the gold standard method of diagnosis is an invasive procedure that might not be suitable in all scenarios. Therefore, this first study in Jordan aimed to assess the non-invasive C urea breath test (UBT) and stool antigen test for diagnosis of infection and the successfulness of eradication therapy as alternatives for endoscopy. Read More

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http://dx.doi.org/10.3390/diagnostics10070448DOI Listing

Stress Ulcer Prophylaxis for ICU Patients-Reply.

Authors:
Paul J Young

JAMA 2020 Jul;324(1):102-103

Medical Research Institute of New Zealand, Wellington, New Zealand.

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http://dx.doi.org/10.1001/jama.2020.6768DOI Listing

Accuracy of ICD-9 codes in identifying patients with peptic ulcer and gastrointestinal hemorrhage in the regional healthcare administrative database of Umbria.

PLoS One 2020 6;15(7):e0235714. Epub 2020 Jul 6.

Health Planning Service, Regional Health Authority of Umbria, Perugia, Italy.

Background: Peptic ulcer is a widespread disease, frequently complicated by perforation and bleeding. Administrative databases are useful tool to perform epidemiological and drug utilization studies, but they need a validation process based on a comparison with the original data contained in the medical charts. Our aim was to evaluate the accuracy of the ICD-9 codes in identifying patients with peptic ulcer and gastrointestinal hemorrhage in the regional administrative database of Umbria. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235714PLOS

A Comparison between 10-day and 12-day Concomitant Regimens for Eradication: A Randomized Clinical Trial.

Middle East J Dig Dis 2020 Apr;12(2):106-110

Associate Professor of Gastroenterology, Division of Gastroenterology, Deartment of Medicine, McMaster University Medical Center, Hamiton, Ontarion, Canada.

BACKGROUND infection is one of the most common bacterial infections worldwide, which is associated with peptic ulcer disease and gastric cancer. In this study, we compared the efficacy of 10-day versus 12-day concomitant therapy as the first-line treatment for eradication in Iran. METHODS 218 patients with peptic ulcer disease and naïve infection, were randomly divided into two groups to receive either 10-day or 12-day concomitant regimens, composed of pantoprazole 40 mg, amoxicillin 1000 mg, clarithromycin 500 mg, and metronidazole 500 mg, all given twice daily. Read More

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http://dx.doi.org/10.34172/mejdd.2020.169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320987PMC

The relationship between Helicobacter pylori and chronic kidney disease: update 2020.

Minerva Gastroenterol Dietol 2020 Jul 3. Epub 2020 Jul 3.

Renal Transplantation Center "A. Vercellone", Division of Nephrology Dialysis and Transplantation, Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.

A number of studies has confirmed that the epidemiology of Helicobacter pylori (H. pylori) is changing worldwide, with a decrease especially in developed Countries. Nevertheless, since this Gram-negative bacterium infects almost 50% of the world's population, it remains a global problem. Read More

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http://dx.doi.org/10.23736/S1121-421X.20.02729-4DOI Listing

Peptic Ulcer Disease as a Common Cause of Bleeding in Patients with Coronavirus Disease 2019.

Am J Gastroenterol 2020 Jul;115(7):1139-1140

Department of Internal Medicine, San Matteo Hospital Foundation, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.14309/ajg.0000000000000710DOI Listing

Skipping the Drip: Intravenous Proton Pump Inhibitor Bolus Therapy Leads to Poor Outcomes in High-Risk Bleeding.

Cureus 2020 May 30;12(5):e8362. Epub 2020 May 30.

Gastroenterology and Hepatology, West Virginia University School of Medicine, Morgantown, USA.

Background and Aim The aim of this study was to evaluate the impact of a change in our institute's protocol from continuous intravenous (IV) proton pump inhibitor (PPI) therapy to bolus IV PPI therapy for the treatment of peptic ulcer-related bleeding on patient outcomes. Current guidelines recommend PPI therapy through high-dose IV bolus followed by continuous infusion for bleeding ulcers. Conflicting data have been reported regarding the practice shift to intermittent IV PPI therapy. Read More

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http://dx.doi.org/10.7759/cureus.8362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325381PMC

Comorbidities and Prescribed Medications in Korean Patients with Chronic Hepatitis C: A Nationwide, Population-Based Study.

Gut Liver 2020 Jul 6. Epub 2020 Jul 6.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background/aims: Extrahepatic comorbidities and comedication are important to consider in the treatment of chronic hepatitis C (CHC) patients with direct-acting antivirals (DAAs) due to the risk of drug-drug interaction (DDI) and the effect of comorbidities on clinical outcomes. This study aimed to investigate the detailed profiles of comorbidities and comedication among Korean CHC patients.

Methods: All adult patients (≥18 years old) with a primary diagnostic code of CHC in 2013 were selected from the National Health Insurance claims database. Read More

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http://dx.doi.org/10.5009/gnl19387DOI Listing

Clavulanic Acid in the Scope of Helicobacter pylori Treatment: A Literature Review and Beyond.

Curr Clin Pharmacol 2020 Jul 2. Epub 2020 Jul 2.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid. Jordan.

Background: Helicobacter pylori (H.pylori) infection is the most common cause of peptic ulcer disease and it can be associated with many complications including malignancies. In clinical practice, some clinicians may use clavulanic acid (CA) in combination with amoxicillin or other beta-lactams as an addition to the standard treatment regimens. Read More

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http://dx.doi.org/10.2174/1574884715666200702121417DOI Listing

Use of proton pump inhibitors and risk of rosacea: A nationwide population-based study.

J Dermatol 2020 Jul 1. Epub 2020 Jul 1.

School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Proton pump inhibitors (PPI) are commonly used drugs. However, little is known about the association between PPI use and rosacea. This study aimed to investigate the association between PPI use and rosacea risk. Read More

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http://dx.doi.org/10.1111/1346-8138.15478DOI Listing

Gastrointestinal Stromal Tumor: GIST Another Duodenal Ulcer.

Ochsner J 2020 ;20(2):236-238

Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL.

Gastrointestinal stromal tumors (GISTs), although exceedingly rare, are the most common mesenchymal tumors in the gastrointestinal (GI) tract. GISTs are often asymptomatic; approximately 10% are found incidentally on imaging or endoscopy for other indications, although GI bleeding, intestinal obstruction, and perforation can occur. We present a case of upper GI bleeding from a duodenal GIST. Read More

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http://dx.doi.org/10.31486/toj.18.0167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310177PMC
January 2020

Valentino's Syndrome (with Retroperitoneal Ulcer Perforation): A Rare Clinico-Anatomical Entity.

Am J Case Rep 2020 Jul 2;21:e922647. Epub 2020 Jul 2.

Department of General Surgery, Agios Dimitrios General Hospital, Thessaloniki, Greece.

BACKGROUND In the emergency department pain in the right lower quadrant is a frequent finding and is related to a wide variety of diseases, the most common of which is acute appendicitis. An unusual presentation of pain in the right iliac fossa is due to perforation of a duodenal peptic ulcer. The fluid that originates from the perforated ulcer moves through the paracolic sulcus to the right iliac fossa and causes irritation of the peritoneum and even chemical peri-appendicitis, thereby imitating all the usual causes of pain in the right lower quadrant. Read More

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http://dx.doi.org/10.12659/AJCR.922647DOI Listing

[The efficacy and safety of quadruple therapy without bismuth (concomitant therapy) in the treatment of patients with Helicobacter pylori - associated gastric and duodenal peptic ulcer disease].

Ter Arkh 2019 Aug 15;91(8):28-33. Epub 2019 Aug 15.

Yevdokimov Moscow State University of Medicine and Dentistry.

Aim: Evaluation of the efficacy and safety of quadrupletherapy without bismuth (concomitant therapy) in patients with Helicobacter pylori - associated gastric ulcer and duodenal ulcer in the framework of a comparative research in the population of patients in Russia.

Materials And Methods: A prospective randomized trial was conducted, which included 210 patients with H. pylori - associated gastric/duodenal ulcer without complications. Read More

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http://dx.doi.org/10.26442/00403660.2019.08.000382DOI Listing

[Pharmacological and clinical feature of rebamipide: new therapeutic targets].

Ter Arkh 2020 Apr 27;92(2):104-111. Epub 2020 Apr 27.

Loginov Moscow Clinical Research Center.

Rebamipide is a cytoprotector developed in Japan where it has been successfully used for the treatment of stomach diseases for 30 years. Initially discovered effects of the drug included the induction of prostaglandins and the elimination of free oxygen radicals. Recent studies discovered new therapeutic targets of the drug, its new forms that made possible using rebamipid for the treatment of such diseases as NSAID enteropathy, ulcerative colitis, radiation colitis, pouchitis, enteropathy with impaired membrane digestion. Read More

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http://dx.doi.org/10.26442/00403660.2020.02.000569DOI Listing

[General and particular issues of etiopathogenesis of peptic ulcer and gastric cancer: current status of the problem].

Ter Arkh 2020 Apr 27;92(2):97-103. Epub 2020 Apr 27.

Sechenov First Moscow State Medical University (Sechenov University).

The development of peptic ulcer (PU) and gastric cancer (GC) is the result of the interaction of various internal and external factors. Moreover, if the role ofHelicobacter pylori(H. pylori) in the development of diseases of the stomach is fully established, the significance of many other factors continues to be discussed. Read More

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http://dx.doi.org/10.26442/00403660.2020.02.000485DOI Listing

Clinical Management of Infectious Diarrhea.

Rev Recent Clin Trials 2020 Jun 28. Epub 2020 Jun 28.

Fondazione Policlinico Universitario A. Gemelli IRCCS - Rome. Italy.

Background: Infectious diarrhea is the most common cause of diarrhea worldwide and is responsible for more deaths than other gastrointestinal tract diseases such as gastrointestinal cancers, peptic ulcer disease or inflammatory bowel disease. Diarrheal disease still represents the 8th leading cause of death worldwide, with more than 1,6 million attributed fatalities in 2016 alone. The majority of cases can be divided into three principal clinical presentations: acute watery diarrhea lasting 5-10 days and normally self-limiting, bloody diarrhea (dysentery), and persistent diarrhea with or without intestinal malabsorption. Read More

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http://dx.doi.org/10.2174/1574887115666200628144128DOI Listing

Randomised controlled trial comparing efficacy and safety of high versus low Low-Molecular Weight Heparin dosages in hospitalized patients with severe COVID-19 pneumonia and coagulopathy not requiring invasive mechanical ventilation (COVID-19 HD): a structured summary of a study protocol.

Trials 2020 Jun 26;21(1):574. Epub 2020 Jun 26.

Servizio Formazione, Ricerca e Innovazione, Azienda Ospedaliero-Universitaria di Modena, Ospedale Policlinico, Modena, Italy.

Objectives: To assess whether high doses of Low Molecular Weight Heparin (LMWH) (i.e. Enoxaparin 70 IU/kg twice daily) compared to standard prophylactic dose (i. Read More

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http://dx.doi.org/10.1186/s13063-020-04475-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316577PMC

Gastric xanthelasma may be a warning sign of intestinal metaplasia: A cross‑sectional study.

Oncol Rep 2020 Jun 19. Epub 2020 Jun 19.

Department of Gastroenterology, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai 201801, P.R. China.

Certain conflicting conclusions have been drawn that gastric xanthelasma is related to H. pylori, atrophic gastritis, intestinal metaplasia, and early gastric cancer. The aim of this study was to examine the relationship between gastric xanthelasma and upper gastrointestinal (GI) endoscopic or pathological features. Read More

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http://dx.doi.org/10.3892/or.2020.7651DOI Listing

Endoscopic naso-biliary and -pancreatic duct drainage for refractory post-bulbar duodenal ulcer bleeding.

Dig Endosc 2020 Jun 23. Epub 2020 Jun 23.

Department of Hepatobiliary Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan.

Bleeding peptic ulcer is usually manageable with endoscopic hemostasis and gastric acid suppressants; however, recurrent bleeding sometimes occurs, especially in patients with comorbidities . A woman in her 60s who had received bone marrow transplantation for mycosis fungoides 2 months earlier received 30 mg methylprednisolone for graft-versus-host disease (GVHD). She presented with anemia and melena, and emergency esophagogastroduodenoscopy (EGD) revealed a bleeding ulcer next to the peri-ampullary diverticulum. Read More

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http://dx.doi.org/10.1111/den.13781DOI Listing

AGA Clinical Practice Update on Endoscopic Therapies for Non-Variceal Upper Gastrointestinal Bleeding: Expert Review.

Gastroenterology 2020 Jun 20. Epub 2020 Jun 20.

Division of Gastroenterology, McGill University, Montreal, Quebec, Canada.

Description: The purpose of this AGA Institute Clinical Practice Update is to review the available evidence and expert recommendations regarding the use of endoscopic therapies in treating patients with non-variceal upper GI bleeding.

Methods: This expert review was commissioned and approved by the AGA Institute Clinical Practice Updates Committee (CPUC) and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the CPUC and external peer review through standard procedures of Gastroenterology. This review is framed around the 10 best practice advice points agreed upon by the authors, which reflect landmark and recent published manuscripts in this field. Read More

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http://dx.doi.org/10.1053/j.gastro.2020.05.095DOI Listing

An improved quantitative real-time polymerase chain reaction technology for Helicobacter pylori detection in stomach tissue and its application value in clinical precision testing.

BMC Biotechnol 2020 Jun 22;20(1):33. Epub 2020 Jun 22.

Department of Clinical Microbiology and Immunology, Faculty of Pharmacy and Medical Laboratory Sciences, Third Military Medical University (Army Medical University), No. 30 Gaotanyan Street, Chongqing, 400038, People's Republic of China.

Background: Helicobacter pylori (H. pylori) infection is a serious human health threat. The empiric H. Read More

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http://dx.doi.org/10.1186/s12896-020-00624-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310109PMC

Analysis of the Relation between Periodontitis and Chronic Gastritis/Peptic Ulcer: A Cross-Sectional Study Using KoGES HEXA Data.

Int J Environ Res Public Health 2020 Jun 18;17(12). Epub 2020 Jun 18.

Department of Internal Medicine, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong 18450, Korea.

The aim of the present study was to investigate the association between periodontitis and chronic gastritis/peptic ulcer using a cross-sectional study design. The present prospective cohort study used epidemiological data from the Korean Genome and Epidemiology Study (KoGES) recorded from 2004 to 2016. Among 173,209 participants, 9983 with periodontitis and 125,336 with no periodontitis were selected. Read More

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http://dx.doi.org/10.3390/ijerph17124387DOI Listing

No news is good news? Three-year postdischarge mortality of octogenarian and nonagenarian patients following emergency general surgery.

J Trauma Acute Care Surg 2020 Jul;89(1):230-237

From the Division of Trauma, Emergency Surgery, and Surgical Critical Care (N.N., J.H., M.K., J.M.L., N.K., G.V., D.K., P.F., N.S., A.M., M.R., H.M.A.K.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Department of Surgery (N.N.), and Department of Anesthesiology (M.K.), Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand; and Center for Outcomes and Patient Safety in Surgery (H.M.A.K.), Massachusetts General Hospital, Boston, Massachusetts.

Background: Outcome data on the very elderly patients undergoing emergency general surgery (EGS) are sparse. We sought to examine short- and long-term mortality in the 80 plus years population following EGS.

Methods: Using our institutional 2008-2018 EGS Database, all the 80 plus years patients undergoing EGS were identified. Read More

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http://dx.doi.org/10.1097/TA.0000000000002696DOI Listing

Abdominal Surgery in Patients with COVID-19: Detection of SARS-CoV-2 in Abdominal and Adipose Tissues.

Ann Surg 2020 Jun 16. Epub 2020 Jun 16.

Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.

: Multiple tissue samples were obtained during emergent abdominal surgery in four patients with coronavirus disease 2019 (COVID-19) to examine for tissue involvement by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first patient underwent a laparoscopic cholecystectomy for gallbladder empyema and died from severe respiratory failure. The second patient with Crohn's disease underwent emergent laparotomy for a perforation in the terminal ileum and recovered. Read More

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http://dx.doi.org/10.1097/SLA.0000000000004165DOI Listing

Proton Pump Inhibitor-Induced Galactorrhea in a Kidney Transplant Recipient: A Friend or Foe?

Case Rep Transplant 2020 13;2020:8108730. Epub 2020 May 13.

Department of Medicine, Division of Nephrology and Transplantation, University of Vermont Medical Center, Burlington, Vermont, USA.

Over the last decades, proton pump inhibitors (PPIs) have been widely used as the mainstay for treatment and prevention of gastrointestinal side effects, gastroesophageal reflux, and peptic ulcer disease. However, their safety profile has come into question recently after reports relating them to several side effects as well as kidney disease. Omeprazole, one of the mainly used PPIs, is almost entirely metabolized by the liver but the resulting metabolites are renally excreted. Read More

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http://dx.doi.org/10.1155/2020/8108730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254079PMC

Ameliorative effect of Boesenbergin A, a chalcone isolated from Boesenbergia rotunda (Fingerroot) on oxidative stress and inflammation in ethanol-induced gastric ulcer in vivo.

J Ethnopharmacol 2020 Jun 18:113104. Epub 2020 Jun 18.

Substance Abuse and Toxicology Research Center, Jazan University, PO Box 114, Jazan, Saudi Arabia.

Ethnopharmacological Relevance: Boesenbergia rotunda (L.) Mansf. Kulturpfl. Read More

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http://dx.doi.org/10.1016/j.jep.2020.113104DOI Listing

Virulence of Helicobacter pylori outer membrane proteins: an updated review.

Eur J Clin Microbiol Infect Dis 2020 Jun 17. Epub 2020 Jun 17.

Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

Helicobacter pylori (H. pylori) infection is associated with some gastric diseases, such as gastritis, peptic ulcer, and gastric cancer. CagA and VacA are known virulence factors of H. Read More

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http://dx.doi.org/10.1007/s10096-020-03948-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299134PMC

Validation of prognostic scoring systems for predicting 30-day mortality in perforated peptic ulcer disease.

Turk J Surg 2019 Dec 16;35(4):252-258. Epub 2019 Dec 16.

Department of Surgery, Medical College Baroda and Sir Sayajirao General Hospital, Vadodara, India.

Objectives: Perforations in Peptic Ulcer Disease are known to cause considerable morbidity and mortality. The objective of this study was to compare efficacy of known clinical parameters and three existing scoring systems in predicting 30-day mortality and determining mortality risk stratification based on risk factors.

Material And Methods: This was a prospective observational study of 190 patients operated for perforated peptic ulcer over a period of 14 months at a 1500 bed tertiary care university hospital in Western India. Read More

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http://dx.doi.org/10.5578/turkjsurg.4211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282445PMC
December 2019

Effect of sodium butyrate on gastric ulcer aggravation and hepatic injury inflicted by bile duct ligation in rats.

Saudi Pharm J 2020 Jun 25;28(6):675-682. Epub 2020 Apr 25.

Department of Pathology, Faculty of Medicine, Alexandria University, Egypt.

Background And Aim: Cholestasis is positively associated with an increased risk of peptic ulceration. The present study investigated the aggravating effect of cholestasis on piroxicam-induced gastric ulceration. The study also evaluated the effect of sodium butyrate (SoB) on piroxicam-induced gastric ulceration in cholestatic animals and its effect on hepatic tissues and both effects were compared to ursodeoxycholic acid (UDCA) as a standard anticholestatic drug. Read More

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http://dx.doi.org/10.1016/j.jsps.2020.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292876PMC
June 2020
1.000 Impact Factor

Changing pattern of perforated PUD: Are NSAIDs to be blamed?

Turk J Surg 2019 Jun 13;35(2):105-110. Epub 2019 Jun 13.

Nnamdi Azikiwe Üniversitesi Eğitim Hastanesi, Cerrahi Bölümü, Nnewi, Nijerya.

Objectives: This study aimed to determine if there is association between gastric perforation and non-steroidal anti-inflammatory drugs (NSAIDs) abuse in patients presenting with perforated peptic ulcer disease (PPUD).

Material And Methods: The data were collected retrospectively from May 2011 to May 2015 and then prospectively until December 2017. Sixty patients diagnosed with PPUD on exploratory laparotomy were evaluated. Read More

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http://dx.doi.org/10.5578/turkjsurg.4145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796067PMC

Management of gastric outlet obstruction: Focusing on endoscopic approach.

World J Gastrointest Pharmacol Ther 2020 Jun;11(2):8-16

Division of Gastroenterology, Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan 48108, South Korea.

Gastric outlet obstruction (GOO) is a medical condition characterized by epigastric pain and postprandial vomiting due to mechanical obstruction. The obstructions typically involved in GOO can be benign or malignant. Peptic ulcer disease is the most common cause of benign GOO, and malignant causes include gastric cancer, lymphoma, and gastrointestinal stromal tumor. Read More

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http://dx.doi.org/10.4292/wjgpt.v11.i2.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288729PMC

Epidemiological investigation of infection in elderly people in Beijing.

World J Clin Cases 2020 Jun;8(11):2173-2180

Department of Gastroenterology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Background: The () infection rate in China is approximately 50%. is a pathogenic factor of peptic ulcer and chronic gastritis. In addition, infection may also be associated with a variety of cardiovascular diseases in elderly people, such as arteriosclerosis, coronary heart disease, and cerebral infarction, having deleterious effect on their health. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i11.2173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281052PMC

Primary Resistance Pattern of to Antibiotics in Adult Population: A Systematic Review.

Infect Drug Resist 2020 28;13:1567-1573. Epub 2020 May 28.

Clinical Pharmacy Unit, School of Pharmacy, College of Health Science, Mekelle University, Mekelle, Ethiopia.

Background: is a spiral-shaped gram-negative bacteria associated with peptic ulcer, gastritis and gastric cancer. The global burden and occurrence of infection remains prevalent and worldwide. Despite this, the trend of the bacterial resistance is not recently studied which can help in the adoption of global, regional and local prevention strategies. Read More

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http://dx.doi.org/10.2147/IDR.S250200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266407PMC

[Role of Hemostatic Clips as Guidance during Transcatheter Arterial Embolization in Patients with Peptic Ulcer Bleeding after Endoscopic Treatment Failure].

Sichuan Da Xue Xue Bao Yi Xue Ban 2020 May;51(3):434-437

Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To investigate the feasibility and clinical efficacy of transcatheter arterial embolization using hemostatic clips as the guidance in the patients with peptic ulcer bleeding after endoscopic treatment failure.

Methods: From February 2009 to October 2018, 33 patients with peptic ulcer bleeding who were treated with transcatheter arterial embolization after endoscopic treatment failure were included in the study. Clinical success rate, 30-d mortality rate and complication rate were observed. Read More

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http://dx.doi.org/10.12182/20200560604DOI Listing

Pattern and outcome of perforated peptic ulcer disease patient in four teaching hospitals in Addis Ababa, Ethiopia: a prospective cohort multicenter study.

BMC Surg 2020 Jun 15;20(1):135. Epub 2020 Jun 15.

CHS, SOM, AAU, Addis Ababa, Ethiopia.

Background: Perforated peptic ulcer disease is a surgical emergency with a high morbidity and mortality. The socio-demographic characteristic and the factors associated with morbidity and mortality seems to differ between the developed and developing world. This is the first a prospective cohort study in Ethiopia designed to analyze pattern and outcome of patients with perforated peptic ulcer disease in four teaching hospitals affiliated with SOM, CHS of Addis Ababa University. Read More

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http://dx.doi.org/10.1186/s12893-020-00796-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296920PMC
June 2020
1.240 Impact Factor

Inverse time trends of peptic ulcer and reflux esophagitis show significant association with reduced prevalence of infection.

Ann Med 2020 Jun 22:1-9. Epub 2020 Jun 22.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Recent prevalence and trends of gastric/duodenal ulcer (GU/DU) and reflux esophagitis (RE) are inadequate. We reviewed the records of consecutive 211,347 general population subjects from 1991 to 2015. During the 25 years, the prevalence of GU and DU has gradually decreased (from 3. Read More

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http://dx.doi.org/10.1080/07853890.2020.1782461DOI Listing
June 2020
3.886 Impact Factor

Enhanced Recovery After Emergency Surgery: Utopia or Reality?

Cir Esp 2020 Jun 9. Epub 2020 Jun 9.

Servicio de Cirugía general y del Aparato Digestivo, Hospital General Universitario de Elche, Elche, Alicante, España.

Enhanced Recovery After Surgery (ERAS) constitutes the application of a series of perioperative measures based on the evidence, in order to achieve a better recovery of the patient and a decrease of the complications and the mortality. These ERAS programs initially proved their advantages in the field of colorectal surgery being progressively adopted by other surgical areas within the general surgery and other surgical specialties. The main excluding factor for the application of such programs has been the urgent clinical presentation, which has caused that despite the large volume of existing literature on ERAS in elective surgery, there are few studies that have investigated the effectiveness of these programs in surgical patients in emergencies. Read More

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http://dx.doi.org/10.1016/j.ciresp.2020.04.017DOI Listing

Physicians' adherence to management guidelines for H. pylori infection and gastroesophageal reflux disease: a cross-sectional study.

Isr J Health Policy Res 2020 Jun 11;9(1):28. Epub 2020 Jun 11.

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, 6997801, Tel Aviv, Israel.

Background: Primary care physicians (PCPs) play a pivotal role in the management of illnesses of the digestive tract. The study aim was to assess the adherence of PCPs to the guidelines on the management of Helicobacter pylori (H. pylori) infection and gastroesophageal reflux disease (GERD) in adults. Read More

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http://dx.doi.org/10.1186/s13584-020-00389-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291643PMC

Early and recurrent hospitalization after kidney transplantation: Analysis of a contemporary canadian cohort of kidney transplant recipients.

Clin Transplant 2020 Jun 9:e14007. Epub 2020 Jun 9.

Division of Nephrology, Department of Medicine, Dalhousie University/Nova Scotia Health Authority, Halifax, NS, Canada.

Hospital readmission is a common occurrence following kidney transplantation, but less is known about the predictors of early and recurrent hospitalization. We analyzed a cohort of adult kidney transplant recipients in Nova Scotia, Canada, from January 2010 to December 2015. Readmission rates for 30 days, 6 months, and 1 year were calculated as a proportion of total transplants. Read More

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http://dx.doi.org/10.1111/ctr.14007DOI Listing

Clinical profile of patients presenting with dysphagia - an experience from a tertiary care center in North India.

JGH Open 2020 Jun 29;4(3):472-476. Epub 2019 Nov 29.

Department of Gastroenterology, Sir Sunderlal Hospital, Institute of Medical Sciences Banaras Hindu University Varanasi India.

Background And Aim: Dysphagia can lead to substantial morbidity and mortality, especially in the elderly. It has both benign and malignant causes. Despite having a varied etiology, there have been few studies in India. Read More

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http://dx.doi.org/10.1002/jgh3.12284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273703PMC

The Diagnostic Values of Ischemia-Modified Albumin in Patients with Acute Abdominal Pain and Its Role in Differentiating Acute Abdomen.

Emerg Med Int 2020 14;2020:7925975. Epub 2020 May 14.

Kilis State Hospital, Emergency Room, Kilis, Turkey.

Aim: The aim of this study was to evaluate the diagnostic value of serum ischemia-modified albumin (IMA) levels in patients presenting to the emergency department with acute abdominal pain and its use in differentiating acute surgical abdomen.

Methods: This single-center prospective cross-sectional study included 334 adult patients who presented to the emergency department. These consisted of 194 patients (Group 1) with nontraumatic abdominal pain commencing in the preceding week, who were definitely diagnosed and either hospitalized in a specific department or planned for discharge, and a control group of 140 patients (Group 2). Read More

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http://dx.doi.org/10.1155/2020/7925975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244959PMC

Emergency CT of abdominal complications of ingested fish bones: what not to miss.

Emerg Radiol 2020 Jun 6. Epub 2020 Jun 6.

Grupo Fleury, Rua Cincinato Braga, 282, Bela Vista, São Paulo, SP, 01333-010, Brazil.

Fish bones are the most commonly ingested structures and the most common cause of foreign body perforation of the gastrointestinal tract (GIT). Clinical presentation of foreign body GIT perforation is nonspecific, in many cases with clinical signs of acute abdomen, which can mimic appendicitis, diverticulitis, ulcer peptic disease, and other common inflammatory conditions. Besides, patients commonly do not refer that a fish bone was swallowed. Read More

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http://dx.doi.org/10.1007/s10140-020-01800-6DOI Listing

Aetiologies and outcomes of patients with abdominal pain presenting to an emergency department of a tertiary hospital in Tanzania: a prospective cohort study.

BMC Gastroenterol 2020 Jun 5;20(1):173. Epub 2020 Jun 5.

Emergency Medicine Department, Muhimbili National Hospital, Dar es Salaam, Tanzania.

Background: Abdominal pain in adults represents a wide range of illnesses, often warranting immediate intervention. This study is to fill the gap in the knowledge about incidence, presentation, causes and mortality from abdominal pain in an established emergency department of a tertiary hospital in Tanzania.

Methods: This was a prospective cohort study of adult (age ≥ 18 years) patients presenting to the Emergency Medicine Department of Muhimbili National Hospital (EMD-MNH) in Dar Es Salaam, Tanzania with non-traumatic abdominal pain from September 2017 to October 2017. Read More

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http://dx.doi.org/10.1186/s12876-020-01313-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275297PMC

[Two unusual causes of peptic anastomotic ulcer].

Khirurgiia (Mosk) 2020 (5):100-101

Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Two unusual cases of anastomotic ulcer complicated by bleeding after gastric resection are reported. There were retained antrum in one patient and long 'dry' intestinal loop after laparoscopic Roux resection in another one. Emergency gastric stump resection with Haberer procedure were successfully performed in both cases. Read More

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http://dx.doi.org/10.17116/hirurgia2020051100DOI Listing