89,006 results match your criteria Peptic Ulcer Disease


Helicobacter pylori pathogen inhibits cellular responses to oncogenic stress and apoptosis.

PLoS Pathog 2022 Jun 29;18(6):e1010628. Epub 2022 Jun 29.

Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.

Helicobacter pylori (H. pylori) is a common gastric pathogen that infects approximately half of the world's population. Infection with H. Read More

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Obesity, peptic ulcer disease and metabolic status in the Wuwei Cohort of northwest China: A cross-sectional study.

Asia Pac J Clin Nutr 2022 ;31(2):294-304

The First School of Clinical Medicine, Lanzhou University, Lanzhou, China. Email:

Background And Objectives: Peptic ulcer disease is a common digestive system disease. However, whether peptic ulcer disease and obesity are related is unclear. We assessed the associations of obesity and metabolic status with peptic ulcer disease. Read More

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January 2022

The relationship between helicobacter pylori infection and nodular antral gastritis in pediatric patients.

J Natl Med Assoc 2022 Jun 25. Epub 2022 Jun 25.

Pediatric Infectious Diseases, Selçuk University Medical School, Konya, Turkey.

Background: Helicobacter pylori (H. pylori) is a spiral-shaped gram-negative bacterium that colonizes the gastric mucosa. It is a common infectious agent in children. Read More

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[A comparative analysis of the distribution of the high-risk population of upper gastrointestinal cancer and endoscopic screening compliance in two urban areas and two rural areas in China].

Zhonghua Zhong Liu Za Zhi 2022 Jun;44(6):531-539

Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To analyze and compare the distribution of the high-risk population of upper gastrointestinal (UGI) cancer and the factors influencing the compliance rate of endoscopic screening in urban China and rural China. From 2015 to 2017, an epidemiological survey was conducted on residents aged 40-69 in two rural areas (Luoshan county of Henan province, Sheyang county of Jiangsu province) and two urban areas (Changsha city of Hunan province, Harbin city of Heilongjiang province). As a result, high-risk individuals were recommended for endoscopic screening. Read More

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Editorial: risk of gastric and duodenal ulcers among new users of low-dose aspirin.

Aliment Pharmacol Ther 2022 Jul;56(2):334-335

Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia.

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A population PK-PD model of YH4808, a novel P-CAB, and intragastric pH that incorporated negative feedback by increased intragastric pH onto the systemic exposure to YH4808.

CPT Pharmacometrics Syst Pharmacol 2022 Jun 24. Epub 2022 Jun 24.

Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.

YH4808 is a novel potassium-competitive acid blocker that is under clinical development to treat patients with gastroesophageal reflux disease and peptic ulcer diseases. In this study, the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of YH4808 were modeled in healthy male volunteers who received a single oral dose of YH4808 at 30, 50, 100, 200, 400, 600, and 800 mg or matching placebo and multiple once-daily oral doses of YH4808 at 100, 200, and 400 mg or matching placebo for 7 days. A population PK-PD model adequately described the time-concentration-effect profiles of YH4808. Read More

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Factors Associated with Colorectal Polyps in Middle-Aged and Elderly Populations.

Int J Environ Res Public Health 2022 Jun 20;19(12). Epub 2022 Jun 20.

Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123, Dapi Road, Niaosong District, Kaohsiung 833, Taiwan.

Colorectal polyps are the precursor lesions of most colorectal cancers. This study aimed to evaluate associations between bone mineral density (BMD), metabolic syndrome (MetS), and gastrointestinal diseases with colorectal polyps in middle-aged and elderly populations. A retrospective cross-sectional study was performed using data from the health examination database of a tertiary medical center in southern Taiwan in 2015. Read More

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Antibiotic Resistance of in Children with Gastritis and Peptic Ulcers in Mekong Delta, Vietnam.

Healthcare (Basel) 2022 Jun 17;10(6). Epub 2022 Jun 17.

Department of Pharmacology and Clinical Pharmacy, Can Tho University of Medicine and Pharmacy, Can Tho City 900000, Vietnam.

Background: () infection causes gastritis, duodenal and gastric ulcers, and gastric cancer. eradication efficacy is low worldwide, and antibiotic resistance is the leading cause of therapy failure; therefore, this study was performed to determine the characteristics of antibiotic resistance of in children with gastritis, duodenal and gastric ulcer.

Methods: A cross-sectional study was conducted on 237 pediatric patients diagnosed with gastroduodenal inflammation and ulcer at two hospitals in Vietnam from March 2019 to April 2022. Read More

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What Is the Prevalence of Clinically Significant Endoscopic Findings in Subjects with Dyspepsia? Updated Systematic Review and Meta-analysis.

Clin Gastroenterol Hepatol 2022 Jun 20. Epub 2022 Jun 20.

Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Canada. Electronic address:

Background & Aims: The prevalence of clinically significant endoscopic findings in people with dyspepsia and understanding how symptoms can predict endoscopic pathology can help inform dyspepsia guidelines. We evaluated this in an updated systematic review and meta-analysis.

Methods: We searched MEDLINE, EMBASE and Cochrane CENTRAL and the Cochrane Database of Systematic Reviews from 2010 through to January 2022 to identify relevant articles. Read More

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Analysis of the Effect of Sichs on Gastric Ulcer Rats Based on RNA Sequencing Technique.

Comput Math Methods Med 2022 13;2022:9325836. Epub 2022 Jun 13.

Department of Traditional Chinese Medicine Diagnosis, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.

Objective: To research the mechanism of action and transcriptomic characteristics for the intervention effect of self-made Chaihuang decoction (Sichs) on gastric ulcer (GU) rats with liver qi stagnation and spleen deficiency and to clarify the therapeutic pathway and effective target.

Methods: Thirty SD rats were randomly divided into the control group, model group, and Sichs group (10 rats per group). The model of GU rats with liver qi stagnation and spleen deficiency was established through multifactor compound simulation of traditional Chinese medical (TCM) etiology and acetic acid method. Read More

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GASTROESOPHAGEAL SYMPTOMS AFTER LAPAROSCOPIC GASTRIC BYPASS: MISTAKES IN PERFORMING THE PROCEDURE?

Arq Bras Cir Dig 2022 17;35:e1657. Epub 2022 Jun 17.

Department of Surgery, Hospital "Dr. José J Aguirre", Faculty of Medicine, University of Chile, Santos Dumont 999, Santiago, Chile.

Aim: Laparoscopic Roux-en-Y gastric bypass (LGB) is the recommended procedure for morbidly obese patients with gastroesophageal reflux disease (GERD). However, there have been reported gastroesophageal reflux symptoms or esophagitis after LGB. Few functional esophageal studies have been reported to date. Read More

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Identification of Chemical Constituents in Zhizhu Pills Based on UPLC-QTOF-MSE.

J AOAC Int 2022 Jun 20. Epub 2022 Jun 20.

Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Dalian, 116600 Liaoning, China.

Background: Zhizhu pills (ZZP) is a traditional Chinese medicine prescription, mainly used for clinically treating digestive diseases such as functional dyspepsia, constipation, and peptic ulcer. However, the chemical constituents of ZZP have rarely been reported.

Objective: To establish an ultra high-performance liquid chromatography-quadrupole time of flight-mass spectrometry (UPLC-QTOF-MSE) method for the identification of chemical constituents in ZZP, including individual herbs and complicated Chinese medicinal formula. Read More

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A Cohort Study to Compare Effects between Ulcer- and Nonulcer-Related Nonvariceal Upper Gastrointestinal Bleeding.

Appl Bionics Biomech 2022 10;2022:3342919. Epub 2022 Jun 10.

Department of Gastroenterology, Yantai Mountain Hospital, Yantai, China.

Objective: The aim of this study was to better understand the characteristics and etiology of acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) in recent years in this region and to provide evidence-based medical evidence.

Methods: 100 patients with acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) who met the clinical diagnostic criteria of ANVUGIB admitted to Suzhou First People's Hospital from January 2017 to December 2021 were analyzed, as well as the age difference and change rule. According to age, 100 patients were divided into young (18-39 years), middle-aged (40-59 years), and elderly (60 years and above), and the differences in the three groups were compared. Read More

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Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco.

Med Pharm Rep 2022 Jan 31;95(1):80-87. Epub 2022 Jan 31.

Laboratory of Drug Sciences, Biomedical Research and Biotechnology, Faculty of Medicine and Pharmacy Casablanca, Hassan II University, Casablanca, Morocco.

Aim: The aim of this study was to evaluate the acid-neutralizing capacity (ANC) and other properties of antacid drugs marketed in Morocco.

Methods: Samples of 12 antacids were collected from pharmacies and were subjected to the test described in the US Pharmacopoeia in order to measure their ANC. Other properties such as price and sodium content were also studied. Read More

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January 2022

Benzimidazole derivatives: A versatile scaffold for drug development against Helicobacter pylori-related diseases.

Fundam Clin Pharmacol 2022 Jun 18. Epub 2022 Jun 18.

Clinical Microbiology Research Centre, Ilam University of Medical Sciences, Ilam, Iran.

Helicobacter pylori (H. pylori) is a microaerophilic gastric pathogen and a major contributor to chronic atrophic gastritis, peptic ulcer, and gastric malignancies. The increasing prevalence of H. Read More

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Retrospective analysis of different therapeutic approaches for retroperitoneal duodenal perforations.

Sci Rep 2022 Jun 17;12(1):10243. Epub 2022 Jun 17.

Department of General, Visceral and Transplant Surgery, University Hospital of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

Surgical therapy of duodenal perforation into the retroperitoneum entails high morbidity. Conservative treatment and endoscopic negative pressure therapy have been suggested as promising therapeutic alternatives. We aimed to retrospectively assess outcomes of patients treated for duodenal perforation to the retroperitoneum at our department. Read More

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Trends in proton pump inhibitor use, reflux esophagitis, and various upper gastrointestinal symptoms from 2010 to 2019 in Japan.

PLoS One 2022 17;17(6):e0270252. Epub 2022 Jun 17.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

The increasing usage of proton pump inhibitors (PPIs) has been reported worldwide, but information on PPI use in East Asia is inadequate. This study aimed to examine the trends in PPI use in Japan, along with the changes in histamine H2 receptor antagonist (H2RA) use, disease rate of reflux esophagitis, and the prevalence of upper gastrointestinal symptoms. We analyzed 217,712 healthy subjects (127,607 men and 90,105 women; 51. Read More

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Laparoscopic repair of perforated peptic ulcer: a multicenter, propensity score matching analysis.

BMC Surg 2022 Jun 16;22(1):230. Epub 2022 Jun 16.

Department of Surgery, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, 77 Sakju-ro, 24253, Chuncheon, Korea.

Background: Perforated peptic ulcer (PPU) is a common emergency condition requiring surgery using laparoscopy or open repair of the perforated site. The aim of this study was to assess the role of laparoscopic surgery (LS) based on the safety and efficacy for PPU.

Methods: Medical records of the consecutive patients who underwent LS or open surgery (OS) for PPU at five hospitals between January 2009 and December 2019 were retrospectively reviewed. Read More

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Spontaneous perforated duodenal diverticulum: a case series.

Acta Gastroenterol Belg 2022 Apr-Jun;85(2):387-389

Department of gastroenterology and hepatology, AZ Nikolaas, Sint-Niklaas, Belgium and Faculty of Medicine, Ghent University, Ghent, Belgium.

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Co-infection relationship with Epstein-Barr virus in gastroduodenal diseases with Helicobacter Pylori. Quantitative PCR and EBNA-1 gene-based approach.

Acta Gastroenterol Belg 2022 Apr-Jun;85(2):301-308

Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Medical Microbiology, Istanbul, Turkey.

Objective: Helicobacter pylori (Hp) and Epstein-Barr virus (EBV) are involved in gastric cancer (GC) etiology. EBV/Hp co- infection was thought synergistically increase gastroduodenal disease occurence. We aimed to determine the presence of EBV/Hp co-infection in gastroduodenal diseases. Read More

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Randomized Clinical Trial on the Efficacy of Triple Therapy Versus Sequential Therapy in Helicobacter pylori Eradication.

Cureus 2022 May 10;14(5):e24897. Epub 2022 May 10.

General Surgery, Maroof International Hospital, Islamabad, PAK.

Introduction: () colonization is prevalent all over the world, and it is associated with low socioeconomic status, poor hygiene, and overcrowding. Its eradication is important since it is an etiologic agent for gastritis, peptic ulcer, gastric carcinoma, and mucosa-associated lymphoid tissue lymphoma. Different regimens are available for the eradication of and include triple therapy and sequential therapy. Read More

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Current Utilization of Antifungal Agents for Intra-abdominal Infections Categorized by Patient Risk Factors During Surgical Procedures: A Literature Review.

J Pharm Pract 2022 Jun 15:8971900221108716. Epub 2022 Jun 15.

Department of Pharmacy Practice and Administration, 242956Wegmans School of Pharmacy at St John Fisher College, Rochester, NY, USA.

The high morbidity and mortality rates associated with invasive fungal infections have led to the overutilization of empiric antifungal therapies. With increasing antibiotic resistance, the careful consideration of prophylactic or empiric antifungal use is critical. The purpose of this review is to evaluate the available literature regarding the current practice of utilizing antifungal agents for intra-abdominal infections based on specific surgical procedures and patient risk factors. Read More

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Stress ulcer prophylaxis for critically ill children: routine use needs to be re-examined.

An Pediatr (Engl Ed) 2022 May 19;96(5):402-409. Epub 2021 Mar 19.

Departamento de Pediatría, Facultad de Medicina, Universidad de Menufia, Shibin el-Kom, Egypt.

Introduction: Stress ulcer prophylaxis (SUP) is commonly used in Paediatric Intensive Care Units (PICUs). However, strong evidence for this practice is lacking and there is a dire need for paediatric randomized controlled trials (RCTs). Our aim was to assess the usefulness of SUP with omeprazole in critically ill children. Read More

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Peptic ulcer disease and risk of hip fracture: a general population-based cohort study.

J Clin Endocrinol Metab 2022 Jun 11. Epub 2022 Jun 11.

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.

Aims: Previous studies reported proton pump inhibitors (PPIs) use may increase the risk of fracture; however, the findings may be susceptible to indication bias since peptic ulcer disease (PUD), one major indication for PPIs, may affect skeletal health. Determining whether PUD would increase hip fracture risk may help identify high risk population and explore risk factors.

Methods: We conducted a cohort study using data from The Health Improvement Network (THIN) in the UK. Read More

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Mantle cell lymphoma presenting with severe upper gastrointestinal bleeding: A case report.

Medicine (Baltimore) 2022 Jun 10;101(23):e29236. Epub 2022 Jun 10.

Hematology Department, Hamad Medical Corporation, Doha, Qatar.

Introduction: Although it usually involves extranodal sites such as the gastrointestinal tract in more than 80% of cases, mantle cell lymphoma is considered a rare cause of gastrointestinal bleeding, especially severe and life-threatening bleeding.

Patient Concern: A 60-year-old man with peptic ulcer disease, who presented with severe upper gastrointestinal (GI) bleeding and large gastric ulcer.

Diagnosis: Primary gastric mantle cell lymphoma. Read More

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[Complications of surgical management of non-traumatic acute abdomens of digestive origin at the Yaoundé central hospital, Cameroon (November 2019 - July 2020)].

Med Trop Sante Int 2021 12 26;1(4). Epub 2021 Nov 26.

Département de chirurgie et spécialités, Faculté de médecine et des sciences biomédicales de l'Université de Yaoundé I, Cameroun.

Objective: Acute non-traumatic digestive surgical emergencies are a frequent cause of emergency in Africa. We undertook this study to investigate the morbidity and mortality of these patients in Cameroon, a developing country in Central Africa.

Patients And Methodology: This was an analytical cross-sectional study with prospective data collection, over a period of eight months (November 2019 to July 2020), at the Yaoundé central hospital (Cameroon). Read More

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December 2021

Animal Models and Infection.

J Clin Med 2022 May 31;11(11). Epub 2022 May 31.

Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Oita, Japan.

colonize the gastric mucosa of at least half of the world's population. Persistent infection is associated with the development of gastritis, peptic ulcer disease, and an increased risk of gastric cancer and gastric-mucosa-associated lymphoid tissue (MALT) lymphoma. In vivo studies using several animal models have provided crucial evidence for understanding the pathophysiology of -associated complications. Read More

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Solve study: a study to capture global variations in practices concerning laparoscopic cholecystectomy.

Surg Endosc 2022 Jun 9. Epub 2022 Jun 9.

South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK.

Background: There is a lack of published data on variations in practices concerning laparoscopic cholecystectomy. The purpose of this study was to capture variations in practices on a range of preoperative, perioperative, and postoperative aspects of this procedure.

Methods: A 45-item electronic survey was designed to capture global variations in practices concerning laparoscopic cholecystectomy, and disseminated through professional surgical and training organisations and social media. Read More

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Association of Anti-Secretory Drugs with Upper Gastrointestinal Bleeding in Patients Using Oral Anticoagulants: A Systematic Review and Meta-Analysis.

Am J Med 2022 Jun 6. Epub 2022 Jun 6.

Yale School of Medicine, New Haven, CT; VA Connecticut Healthcare System, West Haven, CT.

Background: The role of anti-secretory drugs for prevention of upper gastrointestinal bleeding in anticoagulated patients is unclear. We investigated this question in a systematic review and meta-analysis.

Methods: We searched Embase, PubMed, Web of Science, Scopus, the Cochrane Library, and clinicaltrials. Read More

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AMPK/mTOR-driven autophagy & Nrf2/HO-1 cascade modulation by amentoflavone ameliorates indomethacin-induced gastric ulcer.

Biomed Pharmacother 2022 Jul 27;151:113200. Epub 2022 May 27.

Department of Pharmacy, University G. d'Annunzio, Chieti-Pescara, Italy; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University,Postal No. 33516, Kafr El Sheikh, Egypt.

Gastric ulcer (GU) is a worldwide gastrointestinal disorder associated with NSAID use. Recently, amentoflavone proved to be a potent autophagy modulator, antioxidant, anti-inflammatory, and anti-apoptotic agent. Eight-week-old male Wistar rats received amentoflavone orally for 14 days at 25, 50, or 100 mg/kg/day. Read More

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