2,488 results match your criteria Penile Squamous Cell Carcinoma


Penile cancer with visceral metastasis and p16/human papillomavirus positivity: An unusual case of long-term survival.

Urol Case Rep 2020 Nov 24;33:101278. Epub 2020 May 24.

Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Squamous cell carcinoma (SCC) of the penis is a rare cancer in the industrialized countries, including the United States. Risk factors for these cancers include inflammatory conditions as well as infection with the human papilloma virus (HPV). Treatment modalities are based on TNM staging and may include surgical management or chemoradiation. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260682PMC
November 2020

HPV16 induces penile intraepithelial neoplasia and squamous cell carcinoma in transgenic mice: first mouse model for HPV-related penile cancer.

J Pathol 2020 Jun 3. Epub 2020 Jun 3.

CITAB, Universidade de Trás-os-Montes e Alto Douro, UTAD, Vila Real, Portugal.

Penile cancer is an under-studied disease that occurs more commonly in developing countries and 30-50% of cases show high-risk human papillomavirus (HPV) infection. Therapeutic advances are slow, largely due to the absence of animal models for translational research. Here, we report the first mouse model for HPV-related penile cancer. Read More

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http://dx.doi.org/10.1002/path.5475DOI Listing

Prognostic value of systemic inflammatory factors NLR, LMR, PLR and LDH in penile cancer.

BMC Urol 2020 May 27;20(1):57. Epub 2020 May 27.

Department of Urology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, 650118, Yunnan, China.

Background: Penile squamous cell carcinoma (PSCC) represents an important public health problem for developing countries. The major prognostic factors in PSCC are pathological subtype, perineural invasion, lymphovascular invasion, depth of invasion and grade, which are hard to obtain precisely before the operation. Besides, micro-metastases will be detected in about 30% of intermediate-risk patients with clinically non-palpable inguinal lymph nodes after inguinal lymph node dissection (ILND). Read More

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http://dx.doi.org/10.1186/s12894-020-00628-zDOI Listing

Clinical outcomes of glansectomy with split-thickness skin graft reconstruction for localized penile cancer.

Can Urol Assoc J 2020 May 12. Epub 2020 May 12.

Division of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada.

Introduction: Penectomy as the traditional surgical treatment of penile cancer, has substantial adverse functional and psychological impact. Glansectomy with split thickness skin graft (STSG) reconstruction aims to provide curative resection while maximizing functional outcomes, and minimizing psychological harm. We describe our outcomes of glansectomy with STSG reconstruction for penile cancer in a Canadian setting. Read More

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http://dx.doi.org/10.5489/cuaj.6277DOI Listing

Prevalence of human papillomavirus and implication on survival in Chinese penile cancer.

Virchows Arch 2020 May 19. Epub 2020 May 19.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China.

We assessed the prevalence of HPV DNA in a large series of Chinese penile cancer and examine its association with the histological subtype, p16 expression, and prognosis. We pathologically categorized 226 invasive penile squamous cell carcinomas and assessed HPV genotyping by real-time PCR and p16 immunohistochemistry. The results were correlated with histopathological and clinical parameters and disease-specific survival (DSS). Read More

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http://dx.doi.org/10.1007/s00428-020-02831-7DOI Listing

Nomograms to predict the presence and extent of inguinal lymph node metastasis in penile cancer patients with clinically positive lymph nodes.

Transl Androl Urol 2020 Apr;9(2):621-628

Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Background: We developed two nomograms to predict the presence of inguinal lymph node metastasis (ILNM) and two or more histologically positive inguinal lymph nodes (ILNs) or one ILN with extranodal extension (ENE) in penile cancer patients with clinically positive inguinal lymph nodes (ILNs).

Methods: This study enrolled 75 penile squamous cell carcinoma (PSCC) patients with clinically positive ILNs. A binary logistic regression model was taken to screen out the risk factors for the presence of ILNM and two or more positive ILNs or one node with ENE in one side. Read More

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http://dx.doi.org/10.21037/tau.2020.01.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215016PMC

Equine penile squamous cell carcinoma: expression of biomarker proteins and EcPV2.

Sci Rep 2020 May 12;10(1):7863. Epub 2020 May 12.

Prostate Cancer Research Centre at the Centre for Stem Cells and Regenerative Medicine, King's College London, London, United Kingdom.

Equine penile squamous cell carcinoma (EpSCC) is a relatively common cutaneous neoplasm with a poor prognosis. In this study, we aimed to determine the protein expression and colocalisation of FRA1, c-Myc, Cyclin D1, and MMP7 in normal (NT), tumour (T), hyperplastic epidermis and/or squamous papilloma (Hyp/Pap), poorly-differentiated (PDSCC), or well-differentiated (WDSCC) EpSCC using a tissue array approach. Further objectives were to correlate protein expression to (i) levels of inflammation, using a convolutional neural network (ii) equine papillomavirus 2 (EcPV2) infection, detected using PCR amplification. Read More

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http://dx.doi.org/10.1038/s41598-020-64014-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217868PMC
May 2020
5.078 Impact Factor

A nomogram incorporating PD-L1, NLR, and clinicopathologic features to predict inguinal lymph node metastasis in penile squamous cell carcinoma.

Urol Oncol 2020 May 7. Epub 2020 May 7.

Department of Urology, Xiangya Hospital, Central South University, Changsha, China. Electronic address:

Background: Accurate preoperative prediction of inguinal lymph node metastasis (LNM) aids in clinical decision making, especially for patients with penile cancer with clinically negative lymph nodes. We aim to develop a nomogram to predict the preoperative risk of LNM by incorporating clinicopathologic features and tumor biomarkers.

Methods: Eighty-four patients with penile cancer with clinically negative lymph nodes were enrolled. Read More

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http://dx.doi.org/10.1016/j.urolonc.2020.04.015DOI Listing

Metastatic penile squamous cell carcinoma with dramatic response to combined checkpoint blockade with ipilimumab and nivolumab.

J Oncol Pharm Pract 2020 May 7:1078155220922602. Epub 2020 May 7.

Division of Hematology/Oncology, University of California Irvine, CA, USA.

Introduction: Prognosis for patients with lymph node positive or metastatic penile squamous cell carcinoma remains poor. Chemotherapy with paclitaxel, ifosfamide, and cisplatin (TIP regimen) is recommended as a first-line option in this cohort of patients. No standard preferred subsequent-line therapy exists for patients with relapsed or refractory penile carcinoma following TIP chemotherapy. Read More

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http://dx.doi.org/10.1177/1078155220922602DOI Listing

Oncological and Functional Outcomes After Organ-Sparing Plastic Reconstructive Surgery for Penile Cancer.

Urology 2020 May 5. Epub 2020 May 5.

Division of Urology, Fundación Oftalmológica de Santander Clínica Ardila Lulle (FOSCAL), Universidad Autonoma de Bucaramanga, Colombia.

Objective: To describe oncological and functional outcomes in patients treated with reconstructive organ-sparing surgery (OSS) for squamous cell carcinoma of the penis. Plastic reconstructive OSS of the penis with a split thickness skin graft has been proposed as a treatment option for penile cancer, with the objective being preservation of physiological voiding and sexual function without comprising oncological control.

Materials And Methods: Multicenter study reporting clinicopathological data of 57 patients with malignant lesions of the penis treated with OSS and plastic reconstructive surgery with split thickness skin graft from 2007 to 2019. Read More

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http://dx.doi.org/10.1016/j.urology.2020.03.058DOI Listing

Recurrent Metastatic Penile Cancer Patient with Positive PD-L1 Expression Obtained Significant Benefit from Immunotherapy: A Case Report and Literature Review.

Onco Targets Ther 2020 21;13:3319-3324. Epub 2020 Apr 21.

Department of Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, People's Republic of China.

Background: Penile squamous cell carcinoma (PSCC) bears poor prognosis due to its rarity and limited treatment options, especially after failure of standard treatments. Effective therapeutic options were desperately needed.

Case Presentation: We report a recurrent metastatic PSCC patient with positive programmed death ligand 1 (PD-L1) expression (≥10%) and tumor mutation burden (TMB) of 8. Read More

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http://dx.doi.org/10.2147/OTT.S231258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183339PMC

Effective combinatorial immunotherapy for penile squamous cell carcinoma.

Nat Commun 2020 May 1;11(1):2124. Epub 2020 May 1.

Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA.

Penile squamous cell carcinoma (PSCC) accounts for over 95% of penile malignancies and causes significant mortality and morbidity in developing countries. Molecular mechanisms and therapies of PSCC are understudied, owing to scarcity of laboratory models. Herein, we describe a genetically engineered mouse model of PSCC, by co-deletion of Smad4 and Apc in the androgen-responsive epithelium of the penis. Read More

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http://dx.doi.org/10.1038/s41467-020-15980-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195486PMC

Racial/ethnic disparities in penile squamous cell carcinoma incidences, clinical characteristics, and outcomes: A population-based study, 2004-2016.

Urol Oncol 2020 Apr 24. Epub 2020 Apr 24.

Department of Dermatology, Dermatology Hospital of Southern Medical University, Guangzhou, People's Republic of China. Electronic address:

Purpose: This study assessed the impact of race/ethnicity on penile squamous cell carcinoma (PSCC) incidence rates, clinical characteristics, and outcomes.

Materials And Methods: Surveillance, Epidemiology and End Results data from 2004 to 2016 was used for this study. We evaluated racial/ethnic differences in clinical characteristics using χ tests. Read More

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http://dx.doi.org/10.1016/j.urolonc.2020.03.003DOI Listing

Definitive Chemoradiotherapy for Locally Advanced, Lymph-node Positive, Nonmetastatic Penile Squamous Cell Carcinoma.

Clin Genitourin Cancer 2020 Mar 3. Epub 2020 Mar 3.

Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT. Electronic address:

Introduction: Locally advanced penile cancer is rare, with few reported studies on the therapeutic role of chemoradiotherapy. We sought to characterize the efficacy and toxicity of definitive chemoradiotherapy for locally advanced, node-positive, squamous cell carcinoma of the penis.

Materials And Methods: Six patients who had refused or were ineligible for surgical resection of clinically staged node-positive squamous cell penile cancer were treated with definitive chemoradiotherapy using either weekly cisplatin or 2 cycles of mitomycin C/5-fluorouracil. Read More

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http://dx.doi.org/10.1016/j.clgc.2020.02.007DOI Listing
March 2020
1.693 Impact Factor

Metastatic Cutaneous Squamous Cell Carcinoma of the Colon Presenting as Transfusion-Dependent Hematochezia.

ACG Case Rep J 2020 Jan 20;7(1):e00303. Epub 2020 Jan 20.

Department of Medicine, NYU Langone Health, New York, NY.

Squamous cell carcinoma (SCC) of the colon is an exceedingly rare clinical diagnosis with few cases reported in the literature. We report a case of a 61-year-old man with a medical history of cutaneous SCC of the penis who presented with hematochezia and was found to have metastatic SCC to the distal transverse colon. To our knowledge, this is the first case of colonic SCC presenting as a metastatic disease from a primary penile site. Read More

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http://dx.doi.org/10.14309/crj.0000000000000303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145165PMC
January 2020

Characteristics of penile cancer in Japan: An analysis of nationwide hospital-based cancer registry data.

Int J Urol 2020 Jun 19;27(6):538-542. Epub 2020 Apr 19.

Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Objectives: To investigate the clinical characteristics of patients with penile cancer in Japan using the nationwide hospital-based cancer registry database.

Methods: Using hospital-based cancer registry data, we described the distribution of age, pathology, tumor-node-metastases classification, and first-course treatment in patients treated between 2012 and 2015. We compared the patterns of first-line treatment between elderly and non-elderly patients. Read More

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http://dx.doi.org/10.1111/iju.14247DOI Listing

A Modified Histopathologic Staging in Penile Squamous Cell Carcinoma Predicts Nodal Metastasis and Outcome Better Than the Current AJCC Staging.

Am J Surg Pathol 2020 Apr 14. Epub 2020 Apr 14.

Departments of Pathology.

Recently, the American Joint Committee on Cancer (AJCC) updated the staging system for penile squamous cell carcinoma. According to it, unlike its previous version, the involvement of urethra does not upstage the tumor; however, the involvement of corpora cavernosa (CC) does. The tumors involving CC are now staged pT3, whereas those involving corpora spongiosa (CS) are staged pT2, irrespective of the involvement of the urethra. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001490DOI Listing

MOHS MICROGRAPHIC SURGERY FOR PENILE CARCINOMA WITH URETHRAL INVASION - A MULTIDISCIPLINARY APPROACH.

J Am Acad Dermatol 2020 Apr 11. Epub 2020 Apr 11.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.04.007DOI Listing

Penile Melanoma In Situ: Long Term Follow Up.

Urology 2020 Apr 11. Epub 2020 Apr 11.

Concord Hospital, Center for Urologic Care, Concord, NH.

Penile melanoma in situ is extremely rare. Various treatments have been reported with good success, however follow up is generally limited to 1 year or less. The optimal treatment regimen, pattern of disease progression and utility of sentinel lymph node biopsy are not established. Read More

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http://dx.doi.org/10.1016/j.urology.2020.03.027DOI Listing

Robot-assisted inguinal lymphadenectomy: preliminary experience and perioperative outcomes from an Italian referral center.

Ther Adv Urol 2020 Jan-Dec;12:1756287220913386. Epub 2020 Apr 1.

Division of Urology, Istituto Europeo di Oncologia, IRCCS, Milan, Italy.

Background: Inguinal lymphadenectomy remains the gold standard for the treatment of inguinal lymph node metastases from penile carcinoma, melanoma, Merkel cell carcinoma, and squamous cell carcinoma (SCC). This procedure is associated with significant complications. In order to reduce morbidity, minimally invasive approaches have been described. Read More

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http://dx.doi.org/10.1177/1756287220913386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132788PMC

A surgical approach to squamous cell carcinoma of penis that also resolved the psychological dysfunction of the patient.

Arch Ital Urol Androl 2020 Apr 7;92(1):58-60. Epub 2020 Apr 7.

1st Department of Urology, National and Kapodistrian University of Athens, Laiko Hospital, Athens.

In this case study, we present an unusual case with squamous cell carcinoma surrounding the penis involving foreskin and glans of penis. In addition, multiple satellite nodules were noted in the pubis. A 57-year-old circumcised heterosexual male patient presented with a penile lesion existing for 10 years. Read More

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http://dx.doi.org/10.4081/aiua.2020.1.58DOI Listing

[Penile squamous cell carcinoma].

Ann Dermatol Venereol 2020 Jun - Jul;147(6-7):482-489. Epub 2020 Apr 1.

Service de dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.

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http://dx.doi.org/10.1016/j.annder.2020.02.005DOI Listing

Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers V: Recommendations on the Use of Immunohistochemical and Molecular Biomarkers in Penile Cancer.

Am J Surg Pathol 2020 Mar 31. Epub 2020 Mar 31.

Pathology and Research Institute and Medical Sciences of National University of Asuncion, Asunción, Paraguay.

Penile cancer and its precursor lesions are morphologically and clinically heterogenous and they can be further characterized by immunohistochemical (IHC) and molecular genetic analyses. According to the current World Health Organization (WHO) classification, penile intraepithelial neoplasia (PeIN) and invasive penile carcinomas can be grouped into human papillomavirus (HPV)-related and non-HPV-related neoplasms. This distinction is clinically relevant for etiological and prognostic reasons. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001477DOI Listing

[Glans-preserving surgery for superficial penile squamous cell carcinoma ≥2 cm in diameter].

Zhonghua Nan Ke Xue 2019 Mar;25(3):243-247

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Objective: To explore the feasibility of glans-preserving surgery (GPS) in the treatment of superficial penile squamous cell carcinoma (PSCC) with the lesion diameter of ≥2 cm.

Methods: We retrospectively analyzed the clinical data on 69 cases of superficial PSCC (≤T1aN0) treated by GPS (n = 36) or radical surgery (total or partial penectomy, n = 33) from July 2007 to July 2017.

Results: The mean tumor diameter and depth of invasion were 3. Read More

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Sarcomatoid Carcinoma of the Penis: An Uncommon Penile Neoplasm.

Iran J Pathol 2020 28;15(2):151-153. Epub 2020 Feb 28.

Department of Surgical Oncology, HCG Manavata Cancer Centre, Nashik, Maharashtra, India.

Sarcomatoid squamous cell carcinomas are extremely rare, high grade, aggressive variant of penile cancers. Sarcomatoid carcinoma are biphasic neoplasms with a combination of both sarcomatoid components and carcinomatous elements. These neoplasms are very rare in the urogenital system. Read More

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http://dx.doi.org/10.30699/ijp.2020.117401.2275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081766PMC
February 2020

PD1/PD-L1 axis in uro-oncology.

Curr Drug Targets 2020 Mar 26. Epub 2020 Mar 26.

Section of Pathological Anatomy, United Hospital, School of Medicine, Polytechnic University of the Marche Region . Italy.

The immune system is important to control tumor development and progression. However, tumor cells and cells of the tumor microenvironment can induce immune escape mechanisms including activation of immune checkpoints such as PD-1/PD-L1. Based on this knowledge, new immune therapies including PD-1 and PD-L1 inhibition have been developed and are already recommended as standard treatment in metastatic bladder and kidney cancer patients. Read More

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http://dx.doi.org/10.2174/1389450121666200326123700DOI Listing

Optimising the selection of candidates for neoadjuvant chemotherapy amongst patients with node-positive penile squamous cell carcinoma.

BJU Int 2020 Jun 1;125(6):867-875. Epub 2020 Apr 1.

University Hospital Rostock, Rostock, Germany.

Objectives: To identify predictors of poor overall survival (OS) amongst patients with penile squamous cell carcinoma (pSCC) with clinical inguinal lymphadenopathy (cN+), in order to define the best candidates for neoadjuvant chemotherapy (NAC).

Patients And Methods: Using an international, multicentre database of 924 patients with pSCC, we identified 334 men who harboured cN+ with available clinical and follow-up data. Lymph node involvement was defined either by the presence of palpable inguinal node disease or by preoperative computed tomography (CT) assessment. Read More

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http://dx.doi.org/10.1111/bju.15054DOI Listing

PD-L1 and p16 Expression in Penile Squamous Cell Carcinoma From an Endemic Region.

Clin Genitourin Cancer 2019 Oct 16. Epub 2019 Oct 16.

PUCRS School of Medicine, Porto Alegre, Brazil; Dana Farber Cancer Institute/Harvard Medical School, Boston, MA; Department of Medical Oncology, Hospital Sao Lucas da PUCRS, Porto Alegre, Brazil.

Background: Penile squamous cell carcinoma (PSCC) is a rare malignancy with higher incidence in developing countries. Treatment options include surgery, radiation therapy, and systemic chemotherapy. However, effective treatments for advanced disease are lacking. Read More

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http://dx.doi.org/10.1016/j.clgc.2019.10.014DOI Listing
October 2019

Up-regulation of indoleamine 2,3-dioxygenase 1 (IDO1) expression and catalytic activity is associated with immunosuppression and poor prognosis in penile squamous cell carcinoma patients.

Cancer Commun (Lond) 2020 Jan 3;40(1):3-15. Epub 2020 Mar 3.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong, 510060, P. R. China.

Background: Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan (Trp) catabolism have been demonstrated to play an important role in tumor immunosuppression. This study examined the expression and catalytic activity of IDO1 in penile squamous cell carcinoma (PSCC) and explored their clinical significance.

Methods: IDO1 expression level, serum concentrations of Trp and kynurenine (Kyn) were examined in 114 PSCC patients by immunohistonchemistry and solid-phase extraction-liquid chromatography-tandem mass spectrometry. Read More

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http://dx.doi.org/10.1002/cac2.12001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163927PMC
January 2020

Angiolymphatic invasion and absence of koilocytosis predict lymph node metastasis in penile cancer patients and might justify prophylactic lymphadenectomy.

Medicine (Baltimore) 2020 Feb;99(9):e19128

Department of Pathology, Ribeirão Preto Medical of School, University of São Paulo (USP), Ribeirão Preto, Brazil.

To analyze possible clinical-pathological parameters and predictors of lymph node metastasis and evaluate the impact of lymphadenectomy in the survival of these patients.A retrospective study of patients diagnosed with penile cancer and submitted to regional lymphadenectomy at two reference hospitals in Maranhão, Northeast, Brazil, an area where the disease has a high incidence. We described here clinical and histopathological characteristics of patients diagnosed between January 2009 and September 2017. Read More

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http://dx.doi.org/10.1097/MD.0000000000019128DOI Listing
February 2020

Prognostic Factors for Penile Cancer and Survival in Response to Multimodality Therapy.

Res Rep Urol 2020 12;12:29-34. Epub 2020 Feb 12.

Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Purpose: To report treatment outcomes of penile cancer in a single institution in Thailand and to identify prognostic factors for survival, highlighting the crucial role of multi-modality treatment (MMT).

Patients And Methods: Squamous cell carcinoma of penis patients who were treated at Srinagarind hospital between 2007-2015 were retrospectively analyzed. Clinical and pathological data were retrospectively reviewed. Read More

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http://dx.doi.org/10.2147/RRU.S238147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024792PMC
February 2020

MIR-107, MIR-223-3P and MIR-21-5P Reveals Potential Biomarkers in Penile Cancer.

Asian Pac J Cancer Prev 2020 Feb 1;21(2):391-397. Epub 2020 Feb 1.

Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.

Background: Inguinal lymph node involvement is the main prognostic factor in patients with penile cancer. However, there is a lack of marker/s for lymph node metastasis. microRNAs have been investigated as potential markers for prognosis of various types of cancer. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.2.391DOI Listing
February 2020

Adherence to European Association of Urology and National Comprehensive Cancer Network Guidelines Criteria for Inguinal and Pelvic Lymph Node Dissection in Penile Cancer Patients-A Survey Assessment in German-speaking Countries on Behalf of the European Prospective Penile Cancer Study Group.

Eur Urol Focus 2020 Feb 20. Epub 2020 Feb 20.

Department of Urology, Ulm University Hospital, Ulm, Germany.

Background: Urologists' adherence to European Association of Urology and National Comprehensive Cancer Network guideline recommendations to perform inguinal (ILND) and pelvic (PLND) lymph node dissection in penile cancer (PC) patients is not known.

Objective: To assess a German-speaking European cohort of urologists based on their criteria to perform ILND and PLND in PC patients.

Design, Setting, And Participants: A 14-item survey addressing general issues of PC treatment was developed and sent to 45 clinical centers in Germany (n = 34), Austria (n = 8), Switzerland (n = 2), and Italy (n = 1). Read More

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http://dx.doi.org/10.1016/j.euf.2020.02.005DOI Listing
February 2020

Filariasis with Squamous Cell Carcinoma: A Hidden Surprise.

Int J Appl Basic Med Res 2020 Jan-Mar;10(1):59-61. Epub 2020 Jan 3.

Department of Surgery, Plastic Surgeon and General Surgeon, JNMC (DMIMS), Sawangi (Meghe), Wardha, India.

Squamous cell carcinoma (SCC) arising with chronic lymphedema is a rare condition, though literature suggests a variety of malignant tumors associated with filariasis. We present a case of 70-year-old male patient with a history of penile and scrotal SCC of filarial origin. We here discuss the unusual association of carcinoma and filariasis and its surgical treatment. Read More

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http://dx.doi.org/10.4103/ijabmr.IJABMR_309_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967344PMC
January 2020

An update on systemic therapy for penile cancer.

Curr Opin Urol 2020 Mar;30(2):229-233

Department of Urology, Medical University of Vienna, Vienna, Austria.

Purpose Of Review: Whereas substantial advances have been made in systemic tumour therapy in the past decade, the prognosis of advanced squamous cell carcinoma (SCC) of the penis remains disproportionally poor. In this review, we aimed to present an update on systemic therapy of penile SCC highlighting the most recent data and future perspectives.

Recent Findings: Lymph node metastases play a key role in treating and assessing the prognosis of patients with penile SCC. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000733DOI Listing

Topographical Evaluation of Penile Lichen Sclerosus Reveals a Lymphocytic Depleted Variant, Preferentially Associated With Neoplasia: A Report of 200 Cases.

Int J Surg Pathol 2020 Jan 22:1066896920901333. Epub 2020 Jan 22.

Instituto de Patología e Investigación, Asunción, Paraguay.

Since the seminal study of Hart and Helwig in 1975, there are few detailed pathological studies of lichen sclerosus (LS). The aims of this study were to provide a detailed histopathological description of penile LS, as well as to explore its relationship with penile intraepithelial neoplasia (PeIN) or invasive carcinoma. We evaluated 200 patients and designed a topographical approach for the histological evaluation focusing in alterations of the following anatomical layers: squamous epithelium, lamina propria, dartos, and corpus spongiosum. Read More

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http://dx.doi.org/10.1177/1066896920901333DOI Listing
January 2020

High-dose-rate brachytherapy for localized penile cancer: Evolution of a technique.

Brachytherapy 2020 Mar - Apr;19(2):201-209. Epub 2020 Jan 17.

Medical Physics, BC Cancer, Kelowna, British Columbia, Canada.

Purpose: High-dose-rate (HDR) brachytherapy is a convenient treatment option for selected patients with T1-T2 penile squamous cell carcinoma (SCC), providing high rates of penile preservation and tumor control. We present the results of penile SCC treated with HDR brachytherapy either interstitially or via a surface mold.

Methods And Materials: Between November 2009 and April 2019, seven patients (2 T1a and 5 T2) were treated with interstitial HDR and 8 (1 Tis, six T1a, and one T1b) with surface mold. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.12.003DOI Listing
January 2020

Systematic Review and Meta-Analysis-Is there a Benefit in Using Neoadjuvant Systemic Chemotherapy for Locally Advanced Penile Squamous Cell Carcinoma?

J Urol 2020 Jun 13;203(6):1147-1155. Epub 2020 Jan 13.

Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

Purpose: Neoadjuvant chemotherapy is a recommended treatment for patients with penile cancer with bulky inguinal lymphadenopathy or unresectable primary tumors, although there is no evidence of its benefit from randomized trials.

Materials And Methods: We conducted a systematic search in Embase® and MEDLINE® for studies reporting on patients who received preoperative neoadjuvant chemotherapy for locally advanced penile squamous cell carcinoma. Objective response rate, pathological complete response, grade 3 or greater toxicity and overall mortality were evaluated in terms of neoadjuvant chemotherapy type, which was dichotomized as nontaxane-platinum and taxane-platinum regimens. Read More

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http://dx.doi.org/10.1097/JU.0000000000000746DOI Listing

Premalignant male genital dermatoses.

Indian J Sex Transm Dis AIDS 2019 Jul-Dec;40(2):97-104

Department of Skin and VD, Shree Krishna Hospital, Karamsad, Gujarat, India.

The spectrum of conditions affecting the penile skin is varied and ranges from simple, benign dermatoses to premalignant and malignant conditions. Anogenital malignancies and premalignancies are an important personal/public health problem due to their effects on individuals' physical, mental, and sexual health. Furthermore, due to their etiological association with human papillomavirus infection, anogenital malignancies, and premalignancies constitute an immense public health burden. Read More

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http://dx.doi.org/10.4103/ijstd.IJSTD_106_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896386PMC
January 2020

[Glandectomy with cutaneous thigh graft].

Rev Int Androl 2019 Dec 30. Epub 2019 Dec 30.

Servicio de Urología, Hospital Universitario de Fuenlabrada, Madrid, España.

Penile cancer is a neoplasm that predominantly affects males in the sixth decade of life, with an incidence of .3-1 per 100,000. Traditionally, the treatment of the primary lesion has consisted of total or partial amputation of the penis. Read More

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http://dx.doi.org/10.1016/j.androl.2019.09.002DOI Listing
December 2019

Management of the penile squamous cell carcinoma patient after node positive radical inguinal lymph node dissection: current evidence and future prospects.

Curr Opin Urol 2020 Mar;30(2):223-228

Department of Urology.

Purpose Of Review: The level of evidence for current (adjuvant) treatment strategies after node positive inguinal lymphadenectomy is relatively low because of a paucity of prospective studies and controversy exist between the two major guidelines. The present review aims to provide a review of current literature on the available treatment options of patients after a tumor positive inguinal lymph node dissection.

Recent Findings: Patients without inguinal extranodal extension or less than two tumor positive inguinal nodes are at low risk of ipsilateral pelvic nodal disease. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000714DOI Listing

Robot-assisted laparoscopic antegrade versus open inguinal lymphadenectomy: a retrospective controlled study.

BMC Urol 2019 Dec 23;19(1):135. Epub 2019 Dec 23.

Department of Urology, The Fourth Medical Center of Chinese PLA General Hospital, 51th Fucheng Street, Haidian District, Beijing, 100048, China.

Background: To investigate the surgical methods and clinical results of robot-assisted laparoscopic antegrade inguinal lymphadenectomy.

Methods: A retrospective study was performed on clinical data from 19 patients with penile cancer admitted from March 2013 to October 2017. Among them, nine patients underwent robot-assisted laparoscopic antegrade inguinal lymphadenectomy (robot-assisted group) and 10 patients underwent open inguinal lymphadenectomy (open group). Read More

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http://dx.doi.org/10.1186/s12894-019-0571-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929478PMC
December 2019
1.937 Impact Factor

Human papillomavirus genotypes and P16INK4A expression in squamous penile carcinoma in Mexican patients.

BMC Infect Dis 2019 Dec 19;19(1):1068. Epub 2019 Dec 19.

Molecular Oncology Laboratory, Oncology Research Unit, Instituto Mexicano del Seguro Social, CMN S XXI IMSS, Mexico City, Mexico.

Background: Approximately 50% of cases of penile carcinoma (PeCa), a rare neoplasm worldwide, are associated with human papillomavirus (HPV). However, the detection of HPV-DNA is not sufficient to consider it the etiological factor in the development of this type of cancer. Currently, the overexpression of P16INK4A is used as a surrogate biomarker of HPV carcinogenesis. Read More

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http://dx.doi.org/10.1186/s12879-019-4696-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924036PMC
December 2019

Editorial Comment to Prognostic significance of common preoperative laboratory variables in penile squamous cell carcinoma.

Int J Urol 2020 Jan 18;27(1):82. Epub 2019 Dec 18.

Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan.

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http://dx.doi.org/10.1111/iju.14173DOI Listing
January 2020
1.798 Impact Factor

Adherence to the EAU guideline recommendations for systemic chemotherapy in penile cancer: results of the E-PROPS study group survey.

World J Urol 2019 Dec 13. Epub 2019 Dec 13.

Department of Urology, St. Elisabeth-Hospital Straubing, Straubing, Germany.

Objectives: To validate the adherence of urologists to chemotherapy recommendations given in the EAU guidelines on PeCa. The European Association of Urology (EAU) guidelines on penile cancer (PeCa) are predominantly based on retrospective studies with low level of evidence.

Materials And Methods: A 14-item-survey addressing general issues of PeCa treatment was developed and sent to 45 European hospitals. Read More

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http://dx.doi.org/10.1007/s00345-019-03052-7DOI Listing
December 2019
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A novel 'Batman' scrotectomy technique for the management of scrotal lymphoedema following treatment for penile cancer.

Transl Androl Urol 2019 Oct;8(5):448-456

Department of Urology, University College London Hospitals NHS Trust, London, UK.

Background: To describe a novel 'Batman' scrotectomy technique and present our single centre experience in the management of secondary scrotal lymphoedema in penile cancer patients.

Methods: A retrospective review of the medical records of penile cancer patients with extensive and bothersome penoscrotal lymphoedema failing conservative therapy between 2013 and 2018. We analysed patients' demographics, pre-operative disease stage, post-operative outcomes and complications. Read More

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http://dx.doi.org/10.21037/tau.2019.09.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842777PMC
October 2019

Ingenol mebutate therapy in erythroplasia of Queyrat: a new approach.

G Ital Dermatol Venereol 2019 Dec 4. Epub 2019 Dec 4.

Dermatology Unit "Daniele Innocenzi", Department of Medical-Surgical Sciences and Bio-Technologies, Fiorini Hospital, Polo Pontino, Sapienza University of Rome, Rome, Italy.

Background: Erythroplasia of Queyrat (EQ) is a rare squamous cell carcinoma in situ, usually occurring on the glans penis, the prepuce, or the urethral meatus. Therapy is mandatory because it can progress to invasive carcinoma in up to 30% of cases. Treatment options include 5-fluorouracil, curettage, cryotherapy, radiotherapy, laser, partial or total penectomy, and micro surgery, as also with imiquimod and photodynamic therapies. Read More

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http://dx.doi.org/10.23736/S0392-0488.19.06371-5DOI Listing
December 2019

Staged resection in the management of HIV-related anogenital giant condyloma acuminatum. A case report.

Ann Med Surg (Lond) 2019 Dec 1;48:73-76. Epub 2019 Nov 1.

Department of Surgery, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latiff, Bandar Tun Razak, 56000, Kuala Lumpur, Malaysia.

Introduction: Giant condyloma acuminata (GCA), also known as Bushke-Lowenstein tumour, is a rare disease which affects 0.1% of the population. Although histopathologically benign, it tends to be locally destructive. Read More

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http://dx.doi.org/10.1016/j.amsu.2019.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849151PMC
December 2019

A challenging diagnosis of penile sarcomatoid squamous cell carcinoma.

Dermatol Online J 2019 Oct 15;25(10). Epub 2019 Oct 15.

University of Pittsburgh School of Medicine, Pittsburgh, PA.

We report a patient with penile sarcomatoid squamous cell carcinoma (SCC) initially misdiagnosed as condyloma acuminatum. Sarcomatoid SCC is a rare, aggressive, biphasic cancer that often presents a diagnostic challenge and carries a poor prognosis, especially after a delay in diagnosis. Although sarcomatoid SCC may exhibit a broad range of clinical features, the expression of p63 and keratin 34?E12 is a common finding. Read More

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October 2019