2,374 results match your criteria Penile Squamous Cell Carcinoma


Nail Squamous Cell Carcinoma: A Hidden High-risk HPV Reservoir for Sexually Transmitted Infections.

J Am Acad Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

Human papillomavirus (HPV) causes cervical cancer, anal cancer, vulvar cancer, vaginal cancer, penile cancer and oropharyngeal cancer. SCC in the genital region in particular is recognized to be caused by HPV infection, and intraepithelial lesions of the penis and vulva are termed penile intraepithelial neoplasia (PIN) and vulvar intraepithelial neoplasia (VIN), respectively. Although SCC of the nail apparatus is recognized as being associated with high-risk HPVs, it is not well-known in general medicine, and its analysis has been insufficient. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2019.03.070DOI Listing
March 2019
2 Reads

Molecular Detection of Equus caballus Papillomavirus Type 2 in Genital Swabs From Healthy Horses in the Republic of Korea.

J Equine Vet Sci 2019 Jan 21;72:97-100. Epub 2018 Oct 21.

College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea. Electronic address:

Equus caballus papillomavirus type 2 (EcPV-2) is implicated in genital neoplasms in horses, including equine penile papillomas, penile intraepithelial neoplasia, and squamous cell carcinoma (SCC). This virus seldom regresses spontaneously and can result in the development of SCC, which may result in significant clinical damage and economic cost. However, the prevalence of this virus is unknown in clinically unaffected horses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jevs.2018.10.015DOI Listing
January 2019
2 Reads

Organ-Sparing Surgery for a Giant Verrucous Carcinoma of the Penile Shaft: A Case Report and Review of the Literature.

Case Rep Urol 2019 24;2019:1537379. Epub 2019 Feb 24.

Histopathology and Cytology Laboratory Services, Nicosia, Cyprus.

Verrucous Carcinoma is a rare but well-differentiated variant of penile squamous cell carcinoma. Its clinical presentation is usually that of an exophytic cauliflower-like lesion with a broad-based growth pattern. We herein report the case of a 61-year-old man who presented with a giant verrucous carcinoma occupying the dorsal surface of the penile shaft. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/1537379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408996PMC
February 2019
1 Read

[Primary penile cancer: about 11 cases and literature review].

Pan Afr Med J 2018 4;31:14. Epub 2018 Sep 4.

Service de Chirurgie Carcinologique, Institut Salah Azaiz de Tunis, Tunisie.

Penile cancer is a rare pathology in Tunisia where circumcision is a common practice. Squamous cell carcinoma accounts for 95% of cases. Treatment is essentially based on surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11604/pamj.2018.31.14.13077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430962PMC
April 2019
1 Read

Rare Genitourinary Malignancies: Current Status and Future Directions of Immunotherapy.

Eur Urol Focus 2019 Mar 22. Epub 2019 Mar 22.

Genitourinary Oncology Division, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Electronic address:

Treatment options for rare genitourinary malignancies, including adrenocortical carcinoma, bladder/upper tract cancers of variant histology, penile squamous cell carcinoma, and chemotherapy-refractory germ cell tumors, are limited, often with a poor response to systemic therapy. Given preclinical data and efficacy across multiple malignancies, immunotherapy has been and continues to be explored in this challenging setting. In this report, we explore the data for immunotherapy in these tumors and highlight ongoing clinical trials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euf.2019.03.011DOI Listing
March 2019
1 Read

Spectrum of urogenital tumors in males in Sub-Himalayan region: An institutional experience.

J Cancer Res Ther 2019 Mar;15(Supplement):S82-S86

Department of Urology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Aims: The clinical presentation and frequency of urogenital tumors varies in different regions of the world. This study was undertaken to analyze the frequency, clinical presentation, and the histopathological spectrum of the various male urogenital tumors diagnosed over a period of 3 years in a tertiary care institute.

Materials And Methods: Three-year data were collected from the histopathology laboratory, which included all the cases of male urogenital tumors which were diagnosed histopathologically between November 2012 and October 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jcrt.JCRT_565_17DOI Listing
March 2019
3 Reads

HIV status and mortality of surgical inpatients in rural Zimbabwe: A retrospective chart review.

South Afr J HIV Med 2019 24;20(1):812. Epub 2019 Jan 24.

Department of Obstetrics and Gynaecology, Karanda Mission Hospital, Zimbabwe.

Background: People living with HIV treated with antiretroviral therapy (ART) are now living longer and thus many are requiring surgical procedures. For healthcare resource planning, it would be helpful to better understand the prevalence of HIV in surgical patients, the types of surgery HIV-positive patients are undergoing and whether HIV status impacts mortality.

Objective: The goal of this study was to determine the prevalence of HIV in surgical inpatients and the extent of ART coverage, as well as to assess any differences between HIV-positive and HIV-negative patients in type of surgery undergone and in-hospital mortality at Karanda Mission Hospital, Mount Darwin, Zimbabwe. Read More

View Article

Download full-text PDF

Source
http://www.sajhivmed.org.za/index.php/HIVMED/article/view/81
Publisher Site
http://dx.doi.org/10.4102/sajhivmed.v20i1.812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407318PMC
January 2019
4 Reads

Defining the Tumor Microenvironment of Penile Cancer by Means of the Cancer Immunogram.

Eur Urol Focus 2019 Mar 9. Epub 2019 Mar 9.

Department of Gynecology, Center for Gynecologic Oncology Amsterdam, Amsterdam University Medical Center VUmc, Amsterdam, The Netherlands. Electronic address:

Current chemotherapeutic treatment for advanced penile squamous cell carcinoma has substantial side effects and no randomized data to support an overall survival benefit. Immunotherapy with checkpoint blockade is currently being tested in penile cancer patients in clinical trials. The high PD-L1 expression and CD8 T-cell infiltration in penile cancer represent a promising prospect for immunotherapy response in the treatment of locally advanced disease. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24054569193005
Publisher Site
http://dx.doi.org/10.1016/j.euf.2019.02.019DOI Listing
March 2019
6 Reads

Adherence to the EAU guidelines on Penile Cancer Treatment: European, multicentre, retrospective study.

J Cancer Res Clin Oncol 2019 Apr 1;145(4):921-926. Epub 2019 Mar 1.

Department of Urology, G. D'Annunzio University, Chieti, Italy.

Purpose: The European Association of Urology (EAU) guidelines for penile cancer (PC) are exclusively based on retrospective studies and have low grades of recommendation. The aim of this study was to assess the adherence to guidelines by investigating the management strategies for primary tumours and inguinal lymph nodes.

Methods: We retrospectively reviewed the clinical charts of 176 PC patients who underwent surgery in eight European centres from 2010 to 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-019-02864-9DOI Listing
April 2019
3 Reads

Opportunities for use of radiation therapy in penile cancer based on patterns of care in the United States from 2007 to 2013.

Ther Adv Urol 2019 Jan-Dec;11:1756287219828972. Epub 2019 Feb 8.

Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, KS, USA.

Background: Radiation therapy (RT) is an effective modality for the treatment of squamous cell carcinomas of the penis. The National Comprehensive Cancer Network recommends consideration of primary radiation for penile preservation, in surgically unresectable tumors, and as adjuvant therapy for positive margins, bulky groin nodes or pelvic nodes. We performed a population-based analysis to evaluate the usage of RT in penile cancer from 2007 to 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1756287219828972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376511PMC
February 2019
2 Reads

Editorial Comment.

J Urol 2019 03;201(3):548

Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.JU.0000553713.64297.bbDOI Listing

Optimized penile surface mold brachytherapy using latest stereolithography techniques: A single-institution experience.

Brachytherapy 2019 Feb 1. Epub 2019 Feb 1.

University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Electronic address:

Purpose: To describe a technique of penile surface mold high-dose-rate (HDR) brachytherapy and early outcomes.

Methods And Materials: Five patients diagnosed with a T1aN0 squamous cell carcinoma of the penis were treated using a penile surface mold HDR brachytherapy technique. A negative impression of the penis was obtained using dental alginate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brachy.2019.01.002DOI Listing
February 2019
3 Reads
1.987 Impact Factor

No Evidence of Microsatellite Instability and Loss of Mismatch-Repair-Protein Expression in Squamous Cell Carcinoma of the Penis.

Pathobiology 2019 Jan 16:1-7. Epub 2019 Jan 16.

Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Objective: Microsatellite instability (MSI) and a defective mismatch repair (MMR) system were described as beneficial tumor features for response to immune checkpoint therapy (PD-1 blockade). Meanwhile, the FDA approved PD-1/PD-L1 inhibition treatment for any solid tumor showing MSI and/or defects in the MMR system. For squamous cell carcinoma (SCC) of the penis, no data on the frequency of MSI and altered MMR protein expression are available to date. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/495251
Publisher Site
http://dx.doi.org/10.1159/000495251DOI Listing
January 2019
10 Reads

Continuous Spatial Sequences of Lichen Sclerosus, Penile Intraepithelial Neoplasia, and Invasive Carcinomas: A Study of 109 Cases.

Int J Surg Pathol 2019 Jan 7:1066896918820960. Epub 2019 Jan 7.

1 Instituto de Patología e Investigación, Asunción, Paraguay.

Lichen sclerosus (LSc) with penile cancer is found in about two thirds of specimens. It has been hypothesized that LSc represents a precancerous condition. To qualify as such, in addition to cytological atypia and similarity with the invasive tumor, a spatial correlation between LSc and neoplastic lesions needs to be demonstrated. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1066896918820960
Publisher Site
http://dx.doi.org/10.1177/1066896918820960DOI Listing
January 2019
10 Reads

Prevalence of human papillomavirus DNA and p16 in penile cancer and penile intraepithelial neoplasia: a systematic review and meta-analysis.

Lancet Oncol 2019 Jan 17;20(1):145-158. Epub 2018 Dec 17.

Unit of Virus, Lifestyle, and Genes, Danish Cancer Society Research Centre, Copenhagen, Denmark; Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Background: Although previous meta-analyses have examined human papillomavirus (HPV) DNA prevalence in penile cancer, none, to our knowledge, have assessed pooled HPV DNA prevalence in penile intraepithelial neoplasia or p16 percent positivity in penile cancer and penile intraepithelial neoplasia. Therefore, we aimed to examine the prevalence of HPV DNA and p16 positivity in penile cancer and penile intraepithelial neoplasia worldwide.

Methods: In this systematic review and meta-analysis, we searched PubMed, Embase, and the Cochrane Library until July 24, 2017, for English-language articles published from Jan 1, 1986, onwards reporting the prevalence of HPV DNA and p16 positivity, either alone or in combination, in at least five cases of penile cancer or penile intraepithelial neoplasia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(18)30682-XDOI Listing
January 2019
2 Reads

A National Cancer Database-based nomogram to predict lymph node metastasis in penile cancer.

BJU Int 2018 Dec 11. Epub 2018 Dec 11.

Department of Urology, Wake Forest Baptist Health, Winston-Salem, NC, USA.

Objective: To evaluate the predictive nature of several clinicopathological variables by developing a nomogram predictive for lymph node-positive disease using the National Cancer Database cohort of patients with squamous cell carcinoma of the penis.

Methods: Stepwise logistic regression was used to find the best-fit model; remaining clinical variables were used to create a nomogram to predict the probability of lymph node-positive disease.

Results: On multivariate analysis, high pathological grade (3-4 vs 1: odds ratio [OR] 3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bju.14652DOI Listing
December 2018
1 Read

[A Case of Autopsy of Sarcomatoid Carcinoma of the Penis with Metastasis to the Right Ventricle of the Heart].

Hinyokika Kiyo 2018 Nov;64(11):455-458

The Department of Pathology, National Hospital Organization Osaka Minami Medical Center.

A 75-year-old man with a history of early gastric cancer, phimosis and bronchial asthma experienced pain and palpated a mass in the penis in March 2015. After 2 months, he noticed bleeding from the tumor and visited our hospital. Pelvic computed tomography and magnetic resonance imaging revealed a pelvic tumor, bilateral lymphadenopathy, and para-aortic lymphadenopathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14989/ActaUrolJap_64_11_455DOI Listing
November 2018
16 Reads

Overexpression of ID1 promotes tumor progression in penile squamous cell carcinoma.

Oncol Rep 2019 Feb 6;41(2):1091-1100. Epub 2018 Dec 6.

Department of Oncology, Xiangya Hospital, Central South University, Changsha, Human 410008, P.R. China.

Penile squamous cell carcinoma (PSCC) occurs more frequently in developing countries, and is commonly diagnosed at an advanced stage with an unfavorable prognosis. At present, few biomarkers for PSCC have been identified and used in clinical practice. Aberrant expression of inhibitor of DNA binding 1 (ID1) has been suggested as a potential regulator of tumor progression in various types cancer. Read More

View Article

Download full-text PDF

Source
http://www.spandidos-publications.com/10.3892/or.2018.6912
Publisher Site
http://dx.doi.org/10.3892/or.2018.6912DOI Listing
February 2019
15 Reads

Codon 72 Polymorphism and Risk for Squamous Cell Carcinoma of the Penis: A Caucasian Case-Control Study.

J Cancer 2018 20;9(22):4234-4241. Epub 2018 Oct 20.

Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.

Squamous cell carcinoma of the penis is a rare but often aggressive disease. A large proportion of penile cancers are associated with HPV infection, mainly with HPV high-risk subtypes 16 and 18. From other HPV-related malignancies a link between a functional SNP in the p53 gene (rs1042522, p. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/jca.26050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277628PMC
October 2018
14 Reads

Primary urethral squamous cell carcinoma: a unique manifestation of a penile tumor.

J Int Med Res 2019 Feb 5;47(2):999-1004. Epub 2018 Dec 5.

1 Department of Urology, Cantonal Hospital Aarau, Aarau, Switzerland.

This case report describes a unique manifestation of a primary urethral squamous cell carcinoma (SCC) as the underlying pathology in an 80-year-old male patient who underwent partial penectomy due to an enlarging penile mass. Persistent pain in the right knee was discovered to be a pathologic fracture using magnetic resonance imaging. Computed tomography-guided biopsy confirmed metastatic SCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300060518813506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381498PMC
February 2019
3 Reads

Incidental Detection of Metastatic Penile Squamous-Cell Carcinoma With Anti-1-Amino-3-F-18-Fluorocyclobutane-1-Carboxylic Acid (F-Fluciclovine) PET/CT in a Patient With Recurrent Prostate Cancer.

Clin Genitourin Cancer 2019 02 29;17(1):e184-e186. Epub 2018 Oct 29.

Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15587673183074
Publisher Site
http://dx.doi.org/10.1016/j.clgc.2018.10.014DOI Listing
February 2019
23 Reads
1.693 Impact Factor

EGFR mono-antibody salvage therapy for locally advanced and distant metastatic penile cancer: Clinical outcomes and genetic analysis.

Urol Oncol 2019 01 14;37(1):71-77. Epub 2018 Nov 14.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou , China.

Purpose: There are limited therapeutic options for patients with advanced penile squamous cell carcinoma (PSCC) after chemotherapy failure. Thus, we evaluated the feasibility of salvage treatment using the epidermal growth factor receptor (EGFR) mono-antibody nimotuzumab in chemotherapy-failed PSCC patients and explored potential response or resistance biomarkers.

Materials And Methods: Six chemotherapy-failed PSCC patients with locally advanced disease or distant metastasis were enrolled consecutively to nimotuzumab treatment. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10781439183040
Publisher Site
http://dx.doi.org/10.1016/j.urolonc.2018.10.016DOI Listing
January 2019
8 Reads

The role of inguinal lymph node dissection in men with urethral squamous cell carcinoma.

Urol Oncol 2018 12 13;36(12):526.e1-526.e6. Epub 2018 Nov 13.

Department of Surgery, Section of Urology, The University of Chicago, Chicago, IL.

Introduction: Urethral squamous cell cancer is a rare disease with limited clinical recommendations regarding management of the inguinal lymph nodes. Despite the similarities to penile cancer in terms of squamous cell carcinoma (SCC) histology and lymphatic drainage, there is not enough evidence to recommend for or against a prophylactic inguinal lymph node dissection (ILND) in patients with clinically negative groins and a primary tumor stage of T1b or higher. The objective of the study was to identify the rate of prophylactic inguinal lymph node dissection, node positive rate, and overall survival in patients with clinical T1 to T4 stage. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10781439183035
Publisher Site
http://dx.doi.org/10.1016/j.urolonc.2018.09.014DOI Listing
December 2018
15 Reads

A Rare Variant of Penile Squamous Cell Carcinoma in a Man with Paraplegia.

Cureus 2018 Sep 3;10(9):e3244. Epub 2018 Sep 3.

Dermatology, University of Texas Mcgovern Medical School at Houston, Houston, USA.

Verrucous carcinoma (VC) is a rare variant of squamous cell carcinoma (SCC). It is described as a low grade, slow growing, locally infiltrative neoplasm that accounts for 3%-8% of penile SCCs. Here we report a case of destructive VC of the glans penis in a paraplegic man resulting in a hypospadias from the tip of the glans to the corona. Read More

View Article

Download full-text PDF

Source
https://www.cureus.com/articles/13215-a-rare-variant-of-peni
Publisher Site
http://dx.doi.org/10.7759/cureus.3244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217864PMC
September 2018
15 Reads

Penile basal cell carcinoma in a black kidney transplant recipient.

JAAD Case Rep 2018 Nov 29;4(10):969-971. Epub 2018 Oct 29.

Department of Dermatology, Drexel University College of Medicine, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdcr.2018.05.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214887PMC
November 2018
3 Reads

The Diagnosis and Treatment of Penile Cancer.

Dtsch Arztebl Int 2018 Sep;115(39):646-652

Department of Urology, University Medical Center Rostock; Rostock, Germany; Institute of Pathology, University Medical Center Rostock, Rostock, Germany; Department of Urology and Pediatric Urology, Schleswig-Holstein University Hospital (UK-SH), Campus Kiel, Kiel, Germany.

Background: The incidence of penile cancer in Europe lies in the range of 0.9 to 2.1 cases per 100 000 persons per year. Read More

View Article

Download full-text PDF

Source
https://www.aerzteblatt.de/10.3238/arztebl.2018.0646
Publisher Site
http://dx.doi.org/10.3238/arztebl.2018.0646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224543PMC
September 2018
19 Reads

Brown papules on the penis.

Cutis 2018 Sep;102(3):151;152;154

Department of Dermatology, Istanbul Medeniyet University, Goztepe Research and Training Hospital, Turkey.

View Article

Download full-text PDF

Source
September 2018
1 Read

Primary Penile Cancer: The Role of Adjuvant Radiation Therapy in the Management of Extranodal Extension in Lymph Nodes.

Eur Urol Focus 2018 Oct 13. Epub 2018 Oct 13.

Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL, USA.

Background: In head and neck cancer, the presence of extranodal extension (ENE) in lymph nodes (LNs) has been shown prospectively to require adding chemotherapy to postoperative radiation therapy (RT). Limited data exist regarding ENE in LNs from primary penile cancer (PeCa).

Objective: To determine the association of RT and ENE in PeCa. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24054569183030
Publisher Site
http://dx.doi.org/10.1016/j.euf.2018.10.007DOI Listing
October 2018
5 Reads

Expression of LHCG receptors in the human penis.

Aging Male 2018 Oct 15:1-6. Epub 2018 Oct 15.

a Department of Anatomy, Institute of Biomedicine and Translational Medicine , University of Tartu , Tartu , Estonia.

The aim of this study is to investigate the expression of the luteinizing hormone/choriogonadotropin (LHCG) receptor in the human penis to see, if the luteinizing hormone (LH) effects are possible in the spongious and cavernous tissue of the penis. The number of men with erection disturbances increases significantly simultaneously with the elevated LH concentrations between 40 and 70 years. It is possible that the elevated LH concentrations may influence locally the erectile mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13685538.2018.1514001DOI Listing
October 2018
2 Reads

Impact of PI3K-AKT-mTOR Signaling Pathway Up-regulation on Prognosis of Penile Squamous-Cell Carcinoma: Results From a Tissue Microarray Study and Review of the Literature.

Clin Genitourin Cancer 2019 Feb 22;17(1):e80-e91. Epub 2018 Sep 22.

Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL.

Purpose: To assess the prognostic value of PI3K-AKT-mTOR signaling pathway up-regulation in a contemporary cohort of penile squamous-cell carcinoma (PSCC) patients.

Patients And Methods: Tissue microarrays were constructed for 57 patients with invasive PSCC treated at our institution between 2000 and 2013. Immunohistochemical staining was performed for PTEN, AKT, and S6. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clgc.2018.09.012DOI Listing
February 2019
5 Reads

Balanitis xerotica obliterans: a review of diagnosis and management.

Int J Dermatol 2018 Oct 12. Epub 2018 Oct 12.

Department of Dermatology, Royal North Shore Hospital, Sydney, Australia.

Balanitis xerotica obliterans (BXO), or penile lichen sclerosus, is a progressive sclerosing inflammatory dermatosis of the glans penis and foreskin. It is associated with significant morbidity and may result in impaired urinary and sexual function. It was initially described by Stuhmer in 1928, named after its pathological features, and is considered the male equivalent of vulvar lichen sclerosis (LS). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ijd.14236
Publisher Site
http://dx.doi.org/10.1111/ijd.14236DOI Listing
October 2018
4 Reads

P16INK4a expression in patients with penile cancer.

PLoS One 2018 12;13(10):e0205350. Epub 2018 Oct 12.

Department of Pathology, Ribeirão Preto Medical of School, University of São Paulo (USP), Ribeirao Preto, Brazil.

Background: Infection with human papillomavirus (HPV) is reported to be present in 30-50% of penile cancer cases. The immunohistochemical test for p16INK4a is used as an indicator of the presence of HPV and as a prognostic marker for squamous cell carcinomas in various sites. However, the role of this marker in penile carcinoma has not yet been completely elucidated. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205350PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185731PMC
March 2019
13 Reads

Current controversies and developments on the role of lymphadenectomy for penile cancer.

Urol Oncol 2019 Mar 6;37(3):201-208. Epub 2018 Oct 6.

Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL.

Penile squamous cell carcinoma is a rare cancer in men. The main prognosticators of survival for penile cancer patients remain the presence and the extent of lymph node metastasis. While radical inguinal lymphadenectomy has been the cornerstone of regional lymph node management for many years, it is still associated with significant morbidity and psychological distress. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urolonc.2018.08.017DOI Listing
March 2019
6 Reads

Comparative Genomic Profiling of Refractory and Metastatic Penile and Nonpenile Cutaneous Squamous Cell Carcinoma: Implications for Selection of Systemic Therapy.

J Urol 2019 03;201(3):541-548

Upstate Medical University , Syracuse , New York.

Purpose: Metastatic penile squamous cell carcinoma is an aggressive malignancy with limited treatment options. We compared the potential therapy impacting genomic alterations between metastatic penile squamous cell carcinoma and nonpenile metastatic cutaneous squamous cell carcinoma.

Materials And Methods: DNA was extracted from 40 μ of formalin fixed, paraffin embedded samples from 78 cases of metastatic penile squamous cell carcinoma and 338 of metastatic cutaneous squamous cell carcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.juro.2018.09.056DOI Listing
March 2019
8 Reads

Molecular carcinogenesis in equine penile cancer: A potential animal model for human penile cancer.

Urol Oncol 2018 12 27;36(12):532.e9-532.e18. Epub 2018 Sep 27.

Department of Pathobiology and Population Sciences, The Royal Veterinary College, Hawkshead Lane, Hatfield, Hertfordshire AL9 7TA, UK.

Objectives: To evaluate the expression of COX-2, E-cadherin, vimentin, 14-3-3σ, and Phosphatase and tensin homolog (PTEN) tumor-related proteins in equine penile papillomas (ePP) and squamous cell carcinomas (ePSCC), the occurrence of epithelial-mesenchymal transition (EMT) at the invasion front (IF) and compare our findings with current knowledge on human penile squamous cell carcinoma (hPSCC).

Material And Methods: We analyzed, by immunohistochemistry in 45 equine penile proliferative epithelial lesions, the expression of COX-2, E-cadherin, vimentin, 14-3-3σ, and PTEN using monoclonal antibodies. Tumors were histopathologically classified as well-differentiated or poorly differentiated using the IF grading scheme. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urolonc.2018.09.004DOI Listing
December 2018
11 Reads

Human immunodeficiency virus (HIV) infection in men with penile carcinoma is associated with increased prevalence of human papilloma virus infection and younger age at presentation.

S Afr J Surg 2018 Sep;56(3):47-50

Department of Anatomical Pathology, Faculty of Health Sciences, University of the Free State and National Health Laboratory Services (NHLS), Universitas Academic Hospital, Bloemfontein, South Africa.

Background: We investigated the prevalence of HIV and human papilloma virus (HPV) infection in men with penile carcinoma.

Methods: This retrospective study investigated all men with penile carcinoma at the Universitas Academic Hospital in Bloemfontein, South Africa (January 2000-December 2008). Patients' age, HIV status, histological type of carcinoma and evidence of HPV infection were recorded. Read More

View Article

Download full-text PDF

Source
September 2018
2 Reads

Complications associated with intimate body piercings.

Dermatol Online J 2018 Jul 15;24(7). Epub 2018 Jul 15.

Baylor College of Medicine, Houston, Texas.

Intimate body piercings involving the nipple and genitalia have increased in prevalence in both men and women. Despite this increase, there is a deficiency in the literature regarding the short and long-term complications of body piercings, including an increased risk of infection, malignancy, and structural damage to the associated tissue. Breast abscesses associated with nipple piercing can be mistaken as inflammatory carcinoma. Read More

View Article

Download full-text PDF

Source
July 2018
19 Reads

The appropriate number of negative lymph nodes dissection for nonmetastatic penile cancer.

Andrologia 2019 Feb 25;51(1):e13154. Epub 2018 Sep 25.

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Negative lymph nodes status has been attached more attention as a prognostic indicator for nonmetastatic penile cancer. We aimed to identify the appropriate number of negative lymph nodes dissection for nonmetastatic penile cancer using the Surveillance, Epidemiology and End Results database. A total of 1,470 nonmetastatic patients with penile squamous cell carcinoma were identified during 2004 and 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/and.13154DOI Listing
February 2019
23 Reads
1.172 Impact Factor

New insight in penile cancer.

Minerva Urol Nefrol 2018 Dec 19;70(6):559-569. Epub 2018 Sep 19.

Department of Urology, ASL Abruzzo 2, Chieti, Italy -

Penile cancer is a rare disease. Most of penile cancer are squamous cell carcinoma. Diagnosis is based on self-examination, clinical examination and confirmatory biopsy. Read More

View Article

Download full-text PDF

Source
https://www.minervamedica.it/index2.php?show=R19Y2018N06A055
Publisher Site
http://dx.doi.org/10.23736/S0393-2249.18.03215-0DOI Listing
December 2018
4 Reads

[Role of p16(INK4A) in detection of human papillomavirus DNA and stratification of cancer-specific mortality on the basis of long term follow-up data of 34 patients with invasive penile cancer].

Aktuelle Urol 2018 Sep 18. Epub 2018 Sep 18.

Urologische Klinik des Caritas-Krankenhauses St. Josef, Universität Regensburg, Regensburg.

Background:  Human papillomavirus (HPV) infection plays an important role in the pathogenesis of penile squamous cell carcinoma (PSCC) in about one third of the affected patients. Initial data indicate that HPV status could facilitate optimised risk stratification and individualised targeted therapy. The polymerase chain reaction (PCR) assay is the reference method for detection of HPV DNA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0664-0316DOI Listing
September 2018
8 Reads

Elevated serum LAMC2 is associated with lymph node metastasis and predicts poor prognosis in penile squamous cell carcinoma.

Cancer Manag Res 2018 28;10:2983-2995. Epub 2018 Aug 28.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China,

Purpose: Molecular biomarkers, especially serologic factors, have been widely applied in cancer diagnosis and patient follow-up. However, there are few valuable prognostic factors in penile squamous cell carcinoma (PSCC). Here, the authors investigated whether laminin gamma 2 (LAMC2) expression, especially serum LAMC2 (sLAMC2) level, was a suitable prognostic factor that could aid in the prediction of survival in PSCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S171912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118283PMC
August 2018
5 Reads

Human papilloma virus and genitourinary cancers: a narrative review.

Minerva Urol Nefrol 2018 Dec 29;70(6):579-587. Epub 2018 Aug 29.

Unit of Urology, University of Pisa, Pisa, Italy -

Introduction: Human papilloma virus (HPV) is the most common sexually transmitted pathogen and its potential role in the genesis of several diseases such as cervical, head and neck, anal and penile cancers, is now largely recognized. Aim of this review article was to evaluate and summarize the state of the art of HPV-related urogenital cancers, focusing on the potentially innovative methods for the diagnosis of infection that should be used to improve viral causative detection and prevent its diffusion through sexual intercourses.

Evidence Acquisition: The initial search was carried out by using the Medline and the Google Scholar computerized databases through the selected key-words to identify the more recent literature on HPV epidemiology and its relationship with the main relevant urinary tract cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.23736/S0393-2249.18.03141-7DOI Listing
December 2018
24 Reads

[Clinicopathological features and management of penile verrucous carcinoma].

Zhonghua Nan Ke Xue 2018 Janurary;24(1):62-66

Department of Urology, Henan Provincial People's Hospital / People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.

Objective: To explore the clinicopathological characteristics, diagnosis and treatment of penile verrucous carcinoma (VC).

Methods: We retrospectively analyzed the clinical data about 18 penile VC patients at the mean age of 52 (35-66) years. The tumors were cauliflower-like, measuring 2. Read More

View Article

Download full-text PDF

Source
November 2018
20 Reads

F-FDG PET/CT as a prognostic factor in penile cancer.

Eur J Nucl Med Mol Imaging 2019 Apr 24;46(4):855-863. Epub 2018 Aug 24.

Anatomy and Imaging Department, School of Medicine, Federal University of Minas Gerais, Avenida Prof. Alfredo Balena, room 190, Belo Horizonte, 175, Brazil.

Purpose: Penile cancer (PC) is a rare neoplasm with an aggressive behavior and variable prognosis. Lymph node (LN) involvement and pathological features of the primary lesion have been proven to be the most important survival factors. Positron emission tomography/computed tomography with fluorodeoxyglucose labelled with fluorine-18 (F-FDG PET/CT) provides information on tumor staging and works as a prognostic factor, with promising results in other carcinomas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00259-018-4128-7DOI Listing
April 2019
24 Reads

Trends in Human Papillomavirus-Associated Cancers - United States, 1999-2015.

MMWR Morb Mortal Wkly Rep 2018 Aug 24;67(33):918-924. Epub 2018 Aug 24.

Human papillomavirus (HPV) is a known cause of cervical cancer, as well as some oropharyngeal, vulvar, vaginal, penile, and anal cancers. To assess trends, characterized by average annual percent change (AAPC), in HPV-associated cancer incidence during 1999-2015, CDC analyzed data from cancer registries covering 97.8% of the U. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15585/mmwr.mm6733a2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107321PMC
August 2018
34 Reads

Human Papillomavirus-Associated Invasive Condylomas in a Man with Immunosuppressive Comorbidities.

Urol Int 2019 21;102(2):238-242. Epub 2018 Aug 21.

Department of Urology and Pediatric Urology, Saarland University, Homburg, Germany.

Human papilloma virus (HPV) infections are one of the most common sexually transmitted diseases. We present the case of a 77-year-old Caucasian male with enormous genital warts of the penis, scrotum, groins and anus. Lesions were excised by electrosurgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000491098DOI Listing
August 2018
26 Reads

Prognostic Significance of P16 Expression in Penile Squamous Cell Carcinoma: A Meta-Analysis with Trial Sequential Analysis.

Biomed Res Int 2018 19;2018:8345893. Epub 2018 Jul 19.

Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.

Background: Recently, P16 expression has been shown to be correlated with cancer-specific survival (CSS) in penile squamous cell carcinoma (SCC). Therefore, we performed this meta-analysis to clarify the prognostic value of P16 for penile SCC.

Methods: A systematic search was performed in PubMed, Embase, and Web of Science to identify all relevant articles up to May 25, 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/8345893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076906PMC
January 2019
1 Read