Am J Surg Pathol 2022 Mar 17. Epub 2022 Mar 17.
Department of Pathology Uro-Oncology Unit Institute of Hematologic and Oncologic Diseases, Hospital Clinic of Barcelona, University of Barcelona Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clinic-the August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Faculty of Medicine-University of Barcelona Barcelona Institute for Global Health (ISGlobal), Hospital Clínic-Universitat de Barcelona The August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain Institute of Pathology, Lausanne University Hospital, Lausanne University, Lausanne, Switzerland Department of Pathology, Research Institute, Health Sciences University Foundation, Bogotá, Colombia.
Most human papillomavirus (HPV)-independent penile squamous cell carcinomas (PSCCs) originate from an intraepithelial precursor called differentiated penile intraepithelial neoplasia, characterized by atypia limited to the basal layer with marked superficial maturation. Previous studies in vulvar cancer, which has a similar dual etiopathogenesis, have shown that about one fifth of HPV-independent precursors are morphologically indistinguishable from high-grade squamous intraepithelial lesions (HSILs), the precursor of HPV-asssociated carcinomas. However, such lesions have not been described in PSCC. Read More