61,313 results match your criteria Penile Squamous Cell Carcinoma


Gonadotropin- and Adrenocorticotropic Hormone-Independent Precocious Puberty of Gonadal Origin in a Patient with Adrenal Hypoplasia Congenita Due to DAX1 Gene Mutation - A Case Report and Review of the Literature: Implications for the Pathomechanism.

Horm Res Paediatr 2018 Dec 11:1-10. Epub 2018 Dec 11.

Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of Ulm, Ulm, Germany.

Background/aims: Mutations in the DAX1 gene cause X-linked adrenal hypoplasia congenita (AHC) classically associated with hypogonadotropic hypogonadism. Unexpectedly, precocious puberty (PP) has been reported in some cases, its mechanism remaining unclear.

Methods: We longitudinally studied a boy with AHC due to DAX1 gene mutation who developed peripheral PP at age 4. Read More

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December 2018

EBV-positives mukokutanes Ulkus am Penis.

J Dtsch Dermatol Ges 2018 Dec;16(12):1490-1492

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Göttingen.

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December 2018

Simvastatin and the Rho-kinase inhibitor Y-27632 prevent myofibroblast transformation in Peyronie's disease-derived fibroblasts via inhibition of YAP/TAZ nuclear translocation.

BJU Int 2018 Dec 9. Epub 2018 Dec 9.

Laboratory of Experimental Urology, Department of Development and Regeneration, KU, Leuven, Belgium.

Objectives: To uncover the anti-myofibroblast (MFB) properties of Rho-kinase inhibitor (compound Y-27632) and simvastatin in an in vitro model of Peyronie's disease (PD). PD is a sexual debilitating disease caused by an irreversible fibrotic plaque in the penile tunica albuginea (TA). Treatment is limited to surgically restoring anatomical shape. Read More

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December 2018

Overexpression of ID1 promotes tumor progression in penile squamous cell carcinoma.

Oncol Rep 2018 Dec 6. Epub 2018 Dec 6.

Department of Oncology, Xiangya Hospital, Central South University, Changsha, Human 410008, P.R. China.

Penile squamous cell carcinoma (PSCC) occurs more frequently in developing countries, and is commonly diagnosed at an advanced stage with an unfavorable prognosis. At present, few biomarkers for PSCC have been identified and used in clinical practice. Aberrant expression of inhibitor of DNA binding 1 (ID1) has been suggested as a potential regulator of tumor progression in various types cancer. Read More

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December 2018

Comparison between cystourethrography and sonourethrography in preoperative diagnostic management of patients with anterior urethral strictures.

Med Ultrason 2018 Dec;20(4):436-440

Department of Urology, Medical University of Gdańsk, Gdańsk, Poland.

Aim: To evaluate the urethral lesions and the degree of spongiofibrosis using cystourethrography (CUG) and sonourethrography (SUG) in order to propose the best imaging method for further surgical treatment.

Material And Methods: The study involved 66 patients with anterior urethral strictures with indication for urethroplasty. Results of CUG and SUG were compared with each other and data from surgical protocol. Read More

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December 2018

Assessment of selected quality of life domains in patients who have undergone conservative or radical surgical treatment for penile cancer: an observational study.

Sex Health 2018 Dec 12. Epub 2018 Dec 12.

Surgery is the standard treatment for organ-restricted penile cancer, but it is also a disfiguring procedure that can profoundly affect quality of life. Using a survey, in this study we assessed the effect of different surgical invasiveness on satisfaction in selected life domains of patients who underwent penile-sparing surgery and partial penectomy. Forty patients who underwent penile-sparing surgery (n=13) or partial penectomy (n=27) were enrolled in the study. Read More

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December 2018

Young Deaf Adults' Knowledge of Human Papillomavirus (HPV) and Perceived Risk of Vaccine in Preventing Cervical, Anal, Penile, and Oral Cancer.

J Pediatr Adolesc Gynecol 2018 Dec 7. Epub 2018 Dec 7.

Department of Psychology, Gallaudet University, Washington, DC. Electronic address:

Study Objective: Describe knowledge and risk perception of Human Papillomavirus (HPV) among deaf adults who use American Sign Language (ASL) in comparison to hearing adults in the United States.

Design: Secondary HPV knowledge data for the deaf subset sample were drawn from the Health Information National Trends survey in ASL that was administered between 2015 and 2018. HPV knowledge data for the hearing subset sample were drawn from Cycle 5 of the Health Information National Trends survey in English that was administered in 2017. Read More

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December 2018

Clarifying the relative impacts of vascular and nerve injury that culminate in erectile dysfunction in a pilot study using a rat model of prostate irradiation and a thrombopoietin mimetic.

Int J Radiat Oncol Biol Phys 2018 Dec 6. Epub 2018 Dec 6.

Duke University School of Medicine, Department of Radiation Oncology, Durham, NC 27710. Electronic address:

Purpose: Radiation therapy (RT) offers an important and curative approach to treating prostate cancer but is associated with a high incidence of erectile dysfunction (ED). It is not clear if the etiology of radiation-induced ED (RI-ED) is driven by RT-mediated injury to the vasculature, the nerves, or both. This pilot study sought to distinguish the impacts of vascular and nerve injury in RI-ED by applying a vascular radioprotectant in a rat model of prostate RT. Read More

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December 2018

Simultaneous Suprapubic Lipectomy and Penile Prosthesis Implantation.

J Sex Med 2018 Dec;15(12):1818-1823

Department of Andrology, Kasr El Aini Faculty of Medicine, Cairo University, Egypt; Kamal Shaeer Hospital, Cairo, Egypt.

Introduction: A shorter penis is a frequent complaint following penile prosthesis implantation (PPI), and a large redundant suprapubic fat pad can conceal the penis and possibly compromise patient and partner satisfaction with length.

Aim: To evaluate feasibility and outcome of same-session, same-incision, PPI and suprapubic lipectomy (SPL).

Methods: In 22 patients, SPL was performed through an abdominal crease incision. Read More

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December 2018

Six new dactylogyrid species (Platyhelminthes, Monogenea) from the gills of cichlids (Teleostei, Cichliformes) from the Lower Congo Basin.

Parasite 2018 7;25:64. Epub 2018 Dec 7.

Research Group Zoology: Biodiversity, & Toxicology, Centre for Environmental Sciences, Hasselt University, Agoralaan gebouw D, 3590 Diepenbeek, Belgium - Laboratory of Biodiversity and Evolutionary Genomics, University of Leuven, Charles Deberiotstraat 42, 3000 Leuven, Belgium - Department of Botany and Zoology, Faculty of Science, Masaryk University, Kamenice 735/5, 625 00 Brno, Czech Republic - Zoology Unit, Finnish Museum of Natural History, University of Helsinki, Pohjoinen Rautatiekatu 13, 00100 Helsinki, Finland.

The Lower Congo Basin is characterized by a mangrove-lined estuary at its mouth and, further upstream, by many hydrogeographical barriers such as rapids and narrow gorges. Five localities in the mangroves and four from (upstream) left bank tributaries or pools were sampled. On the gills of Coptodon tholloni, Coptodon rendalli, Hemichromis elongatus, Hemichromis stellifer and Tylochromis praecox, 17 species of parasites (Dactylogyridae & Gyrodactylidae, Monogenea) were found, eight of which are new to science. Read More

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December 2018

Simplifying the ShangRing technique for circumcision in boys and men: use of the no-flip technique with randomization to removal at 7 days versus spontaneous detachment.

Asian J Androl 2018 Nov 30. Epub 2018 Nov 30.

EngenderHealth, Nairobi 00100, Kenya.

To assess safety of the no-flip ShangRing male circumcision technique and to determine clinical course and safety of spontaneous detachment (i.e., allowing the device to fall off), we conducted a case series of no-flip ShangRing circumcision combined with a randomized controlled trial of removal 7 days postcircumcision versus spontaneous detachment at two health facilities in Kenya. Read More

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November 2018

Extramammary Paget ’s disease Of Glans Penis: A Rare Case Report

Ir Med J 2018 06 7;111(6):772. Epub 2018 Jun 7.

Department of Urological Surgery, Tallaght Hospital, Dublin 24

We present the case of an 83-year-old man with Extramammary Paget’s disease (EMPD) of the penis. He underwent a total penectomy and histopathology confirms the association of underlying invasive high grade urothelial carcinoma. Penile EMPD is rare and can be misinterpreted for benign skin conditions. Read More

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June 2018
1 Read

Modified Hinderer's Technique for Serious Proximal Hypospadias with Ventral Curvature: Outcomes and Our Experience.

Urol J 2018 Dec 6. Epub 2018 Dec 6.

Department of Pediatric Surgery, Selcuk University Medical Faculty, Konya,Turkey.

Purpose: Hypospadias is a congenital anomaly that includes defi-cient ventral structure of the penis. Proximal hypospadias cases make up 20% of all hypospadias cases. The choice of operative technique for hypospadias repair depends on the severity, and it is influenced by the surgeon's experience and perception of where priorities should lie. Read More

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December 2018
3 Reads

Codon 72 Polymorphism and Risk for Squamous Cell Carcinoma of the Penis: A Caucasian Case-Control Study.

J Cancer 2018 20;9(22):4234-4241. Epub 2018 Oct 20.

Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.

Squamous cell carcinoma of the penis is a rare but often aggressive disease. A large proportion of penile cancers are associated with HPV infection, mainly with HPV high-risk subtypes 16 and 18. From other HPV-related malignancies a link between a functional SNP in the p53 gene (rs1042522, p. Read More

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October 2018

Results from a cross-sectional sexual and reproductive health study among school girls in Tanzania: high prevalence of bacterial vaginosis.

Sex Transm Infect 2018 Dec 5. Epub 2018 Dec 5.

Institute of Tropical Medicine, Antwerp, Belgium.

Objectives: Bacterial vaginosis (BV) increases women's susceptibility to sexually transmitted infections (STIs) and HIV and may partly explain the high incidence of STI/HIV among girls and young women in East and southern Africa. The objectives of this study were to investigate the association between BV and sexual debut, to investigate other potential risk factors of BV and to estimate associations between BV and STIs.

Methods: Secondary school girls in Mwanza, aged 17 and 18 years, were invited to join a cross-sectional study. Read More

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December 2018

Penile intraepithelial neoplasia: Nomenclature, incidence and progression to malignancy in the Netherlands.

Int J Urol 2018 Dec 3. Epub 2018 Dec 3.

Department of Urology, University Medical Center Utrecht, Utrecht, the Netherlands.

Objective: To determine the incidence of penile intraepithelial neoplasia in the Netherlands using a nationwide histopathology registry and to discuss the nomenclature of premalignant penile lesions.

Methods: Data from patients in the Netherlands diagnosed with a premalignant penile lesion between January 1998 and December 2007 were collected from the nationwide histopathology registry (PALGA); this database covers all pathology reports of inhabitants in the Netherlands. The premalignant lesions included were erythroplasia of Queyrat; Bowen's disease; bowenoid papulosis; mild, moderate and severe dysplasia; and carcinoma in situ of the penis. Read More

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December 2018

Ethical issues with early genitoplasty in children with disorders of sex development.

Curr Opin Endocrinol Diabetes Obes 2018 Nov 30. Epub 2018 Nov 30.

Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.

Purpose Of Review: Genitoplasty in children with disorders of sex development (DSD) is an ethically complex issue. From a surgical perspective, genitoplasty in early childhood is preferred because it is felt to be associated with improved tissue healing, decreased risk of complications, and reduced psychological impact of genital surgery. However, advocacy groups and recent ethics literature have argued for deferring genitoplasty until a child reaches decisional maturity. Read More

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November 2018
1 Read

Penile lymphedeme: a very rare complication due to bilateral subinguinal varicocelectomy.

Int Urol Nephrol 2018 Dec 1. Epub 2018 Dec 1.

Department of Urology, School of Medicine, Gazi University, Ankara, Turkey.

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December 2018

Penile prosthesis biofilm formation and emerging therapies against them.

Transl Androl Urol 2018 Dec;7(6):960-967

Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.

Infections are among the most feared and devastating complications of penile prosthesis infections, often requiring surgical exploration and explantation are prosthesis infections. While the rate of infections have decreased due to antibiotic prophylaxis, antiseptic device preparation, increased sterility in implantation techniques and device modifications, infections still occur at a rate of 1-3%. This article reviews the formation of biofilms on penile prostheses and novel, experimental methods to prevent and eradicate them. Read More

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December 2018

What about the partner? -factors associated with patient-perceived partner dyspareunia in men with Peyronie's disease.

Transl Androl Urol 2018 Dec;7(6):935-940

Department of Urology, Mayo Clinic, Rochester, MN, USA.

Background: Limited data are available on how partners of men with Peyronie's disease (PD) are affected by the disease. We sought to characterize PD patients whose curvatures result in pain for their partners during penetrative intercourse.

Methods: We queried a database of all men undergoing initial evaluation for PD at a single clinic between March 2014 and June 2016. Read More

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December 2018

Primary transitional cell carcinoma of penis - A rare presentation.

Urol Case Rep 2019 Mar 23;23:25-26. Epub 2018 Nov 23.

University of Melbourne, Department of Surgery, Austin Hospital, Melbourne, Victoria, Australia.

Primary transitional cell carcinoma arising from the anterior portion of the male urethra is rare, with no recent cases reported in the literature. We present a case of penile TCC with positive urine cytology and a delayed definitive diagnosis. Read More

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Neoadjuvant chemotherapy for penile cancer enabling organ preservation: A case of individualized management for bilateral lymph node metastasis and a bulky primary tumor.

Urol Case Rep 2019 Mar 9;23:3-5. Epub 2018 Nov 9.

Fox Chase Cancer Center, Temple University Health System, 333 Cottman Ave, Philadelphia, PA 19111, United States.

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Application of embryonic equivalents in male-to-female sex reassignment surgery.

Indian J Plast Surg 2018 May-Aug;51(2):155-166

Department of Plastic Reconstructive and Faciomaxillary Surgery, Madras Medical College, Chennai, Tamil Nadu, India.

Introduction: The feeling of incongruence between phenotypic sex and psychological recognition of self-gender is termed gender dysphoria. Transsexualism is the most extreme form of this disorder.

Aims And Objectives: The aims and objectives of the study are to evaluate the esthetic and functional outcome of embryonic equivalents-based male-to-female sex reassignment surgery in transwomen using the institutional scoring system. Read More

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December 2018
2 Reads

Review of Management Options for Active-Phase Peyronie's Disease.

Sex Med Rev 2018 Nov 29. Epub 2018 Nov 29.

Department of Urology and Pediatric Urology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.

Introduction: Peyronie's disease (PD) is a fibrotic disorder that leads to plaque formation in ∼3-9% of adult men. Connective tissue buildup results in plaque formation, penile curvature and shortening, and in some cases, pain. In the active phase of PD, penile pain is a common symptom, often accompanied by progression in curvature. Read More

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November 2018

Placement of Inflatable Penile Implants in Patients With Prior Radical Pelvic Surgery: A Literature Review.

Sex Med Rev 2018 Nov 29. Epub 2018 Nov 29.

Florida Hospital Tampa Urology, Tampa, FL, USA. Electronic address:

Background: Penile prosthesis for erectile restoration remains the only surgical option for medical refractory erectile dysfunction. Many expert prosthetic surgeons recommend special care when placing a reservoir in a patient who has undergone prior radical pelvic surgery (PRPS) due to distortion of anatomy and obliteration of the dead space in the traditionally used space of Retzius.

Aim: Review all the current literature on penile prosthesis implantation in patients with prior pelvic surgery, with an emphasis on tips and tricks for reservoir placement in this unique population. Read More

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November 2018

Sexual Quality of Life and Satisfaction With Penile Prostheses.

Sex Med Rev 2018 Nov 29. Epub 2018 Nov 29.

Division of Urologic Surgery, Duke University, Durham, USA.

Introduction: Penile prosthesis (PP) implantation is associated with high patient satisfaction and improved sexual quality of life (SQoL). The SQoL benefits of PP implantation are generalizable across subpopulations of PP implant patients, but the literature is heterogeneous in design and largely without instruments to specifically measure SQoL changes due to PP, requiring extrapolation from less granular measures.

Aim: To provide a comprehensive review of available literature regarding SQoL with a penile prosthesis. Read More

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November 2018

Intratunical Injection of Human Adipose Tissue-Derived Stem Cells Restores Collagen III/I Ratio in a Rat Model of Chronic Peyronie's Disease.

Sex Med 2018 Nov 29. Epub 2018 Nov 29.

Laboratory for Experimental Urology, Organ Systems, Department of Development and Regeneration, University of Leuven, Leuven, Belgium.

Introduction: Previous studies have shown that the injection of adipose tissue-derived stem cells (ADSCs) into the tunica albuginea (TA) during the active phase of Peyronie's disease (PD) prevents the development of fibrosis.

Aim: To investigate, using an animal model, whether local injection of human ADSCs (hADSCs) can alter the degree of fibrosis in the chronic phase of PD.

Methods: 27 male, 12-week-old rats were divided into 3 equal groups: sham, PD without treatment, and PD treated with hADSCs 1 month after disease induction. Read More

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November 2018

Unintended Consequences: A Review of Pharmacologically-Induced Priapism.

Sex Med Rev 2018 Nov 28. Epub 2018 Nov 28.

Department of Urology, Tulane University, New Orleans, LA, USA. Electronic address:

Background: Priapism has been linked to many commonly prescribed medications, as well as recreational drugs and toxins. Although the incidence of priapism as a result of medication is small, the increasing use of antidepressants, antipsychotics, and recreational drugs may lead to more cases of pharmacologically-induced priapism in the future.

Aim: To provide a comprehensive, up-to-date review of the most common causes of pharmacologically induced priapism and discuss incidence, pathophysiology, and basic management strategies. Read More

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November 2018

Human Oncoviruses: Mucocutaneous Manifestations, Pathogenesis, Therapeutics, and Prevention (Part I: Papillomaviruses and Merkel cell polyomavirus).

J Am Acad Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Center for Clinical Studies, Houston, TX, USA; Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA.

In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Read More

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November 2018

Pericardium in Reconstructive Urologic Surgeries: A Systematic Review and Meta-Analysis.

Urol Int 2018 12 5:1-14. Epub 2018 Dec 5.

Heart Valve Disease Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Introduction: The use of pericardium has been expanded into different surgical modalities; however, there are scarce data regarding the feasibility of the pericardium in reconstructive urologic surgeries. We systematically reviewed the literature on the effectiveness of the pericardial tissue for reconstructive urologic surgeries.

Materials And Methods: PubMed and Scopus were searched online for evidence on the use of the pericardium in urologic surgeries. Read More

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December 2018
2 Reads

The effects of oxytocin on penile tissues in experimental priapism model in rats.

Int Urol Nephrol 2018 Dec 4. Epub 2018 Dec 4.

Department of Urology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey.

Purpose: This study aimed to demonstrate the effects of oxytocin on penile tissues in ischemia-reperfusion injury developed after priapism.

Methods: Forty Wistar Albino strain male rats were divided into four groups. The control group (n = 10) was not intervened. Read More

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December 2018
1.290 Impact Factor

Primary urethral squamous cell carcinoma: a unique manifestation of a penile tumor.

J Int Med Res 2018 Dec 5:300060518813506. Epub 2018 Dec 5.

1 Department of Urology, Cantonal Hospital Aarau, Aarau, Switzerland.

This case report describes a unique manifestation of a primary urethral squamous cell carcinoma (SCC) as the underlying pathology in an 80-year-old male patient who underwent partial penectomy due to an enlarging penile mass. Persistent pain in the right knee was discovered to be a pathologic fracture using magnetic resonance imaging. Computed tomography-guided biopsy confirmed metastatic SCC. Read More

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December 2018

Creation of Clitoral Hood and Labia Minora in Penile Inversion Vaginoplasty in Circumcised and Uncircumcised Transwomen.

Plast Reconstr Surg 2018 Nov;142(5):729e-733e

Ghent, Belgium; and Madison, Wis. From the Department of Plastic and Reconstructive Surgery, University of Ghent; and the Department of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health.

Gender dysphoria, the incongruence between anatomical sex and gender identity, is estimated to affect 1 percent of the population. Creation of a feminine vulva with labia minora remains a technical challenge for surgeons, especially in circumcised patients. The authors present the technique developed by the senior author (S. Read More

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November 2018
2 Reads

Vascularized Composite Allotransplantation: Alternatives and Catch-22s.

Plast Reconstr Surg 2018 Nov;142(5):1320-1326

New York, N.Y. From the Hansjörg Wyss Department of Plastic Surgery, and the Division of Medical Ethics, New York University Langone Medical Center.

Technical success has been achieved in several forms of vascularized composite allotransplantation, including hand, face, penis, and lower extremity. However, the risks of lifelong immunosuppression have limited these procedures to a select group of patients for whom nontransplant alternatives have resulted in unsatisfactory outcomes. Recent reports of facial allograft failure, and subsequent reconstruction using autologous tissues, have reinforced the idea that a surgical contingency plan must be in place in case this devastating complication occurs. Read More

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November 2018

A rare presentation of hidradenocarcinoma within the penis.

Urol Case Rep 2019 Jan 25;22:57-59. Epub 2018 Oct 25.

Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, United Kingdom.

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January 2019
1 Read

Delayed Low-Intensity Extracorporeal Shock Wave Therapy Ameliorates Impaired Penile Hemodynamics in Rats Subjected to Pelvic Neurovascular Injury.

J Sex Med 2018 Nov 30. Epub 2018 Nov 30.

Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA. Electronic address:

Background: Erectile dysfunction (ED) caused by pelvic neurovascular injury (PNVI) is often refractory to treatment. In many cases, erectogenic therapy is administered in a delayed fashion.

Aim: To evaluate penile hemodynamic effects and histologic changes associated with delayed low-intensity extracorporeal shock wave therapy (Li-ESWT) after PNVI ED in a rat model. Read More

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November 2018
1 Read

Acute Post-Inflatable Penile Prosthesis Glans Ischemia: Review of Incidence, Pathophysiology, and Management Recommendations.

J Sex Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address:

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November 2018

Potential Association of Weight-Based Gentamicin with Increased Acute Kidney Injury in Urologic Prosthetic Surgery.

J Sex Med 2018 Nov 30. Epub 2018 Nov 30.

Division of Urology, Virginia Commonwealth University Medical Center, West Hospital, Richmond, VA, USA; Division of Urology, Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA.

Background: Despite the known nephrotoxicity of gentamicin, in 2008 the American Urological Association recommended a weight-based gentamicin dose of 5 mg/kg for antimicrobial prophylaxis during urologic prosthetic surgery.

Aim: To identify and characterize rates of acute kidney injury (AKI) in urologic prosthetic surgery, both before and after the implementation of weight-based gentamicin dosing.

Methods: We performed a single-institution retrospective study of patients receiving perioperative gentamicin during implant, revision, salvage, or explant of inflatable penile prostheses, malleable penile prostheses, or artificial urinary sphincters between the years 2000 and 2017. Read More

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November 2018
2 Reads

Long-Term Therapeutic Effect of Cell Therapy on Improvement in Erectile Function in a Rat Model with Pelvic Neurovascular Injury.

BJU Int 2018 Nov 30. Epub 2018 Nov 30.

Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, 27101, USA.

Objective: To determine the long-term therapeutic effect among three types of human cell types on erectile function recovery in a rodent model of dual neurovascular injured erectile dysfunction (NVED).

Materials And Methods: A dual NVED model was established in athymic rats by crushing the bilateral cavernous nerves and ligations of the bilateral internal pudendal nerve-vessel bundles. At the time of defect creation, three different types of human cell populations (2. Read More

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November 2018

Sexual Enhancing Effect of in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions.

Biomed Res Int 2018 25;2018:6452965. Epub 2018 Oct 25.

Department of Physiology, Faculty of Medicine, Khon Kaen University, 40002, Thailand.

In this study, we aimed to assess the effect and possible underlying mechanism of leaves extract on male sexual behaviors in stress-exposed rats. Male Wistar rats were orally given extract at doses of 25, 100, and 200 mg/kg BW before 12-hour-immobilization exposure for 14 days. Sexual behaviors, serum testosterone and corticosterone levels, TH-positive cells density in nucleus accumbens (NAc) and ventral tegmental area (VTA), MAO-B activity in NAc and medial preoptic area (MPOA), testis histology together with phosphodiesterase type-5 ( PDE-5) activity, and endothelial nitric oxide synthase (eNOS) expression in penis were evaluated after treatment. Read More

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October 2018
1 Read

Penile Metastasis from Rectal Carcinoma: Case Report and Review of the Literature.

Visc Med 2018 Oct 31;34(5):389-392. Epub 2018 Jul 31.

Clinic of Internal Diseases, Family Medicine and Oncology, Faculty of Medicine, Vilnius University, National Cancer Institute, Vilnius, Lithuania.

Background: Metastasis of rectal cancer to the penis is a very rare condition with less than 40 cases found in the literature.

Case Report: We here report a case of a 41-year-old man who was diagnosed with rectal cancer which later metastasized to the penis. The patient was treated with neoadjuvant radiotherapy, underwent rectal resection, had adjuvant chemotherapy, and, despite that, had penile metastasis 2 years later. Read More

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October 2018

Fournier's Gangrene of the Penis following a Human Bite Wound.

Case Rep Urol 2018 25;2018:9798607. Epub 2018 Oct 25.

West Virginia University Department of Urology, USA.

Fournier's gangrene isolated to the penis is exceedingly rare. It is an urologic emergency that requires emergent parenteral antibiotics as well as aggressive irrigation and debridement. While human bite wounds can be overlooked as a serious cause of injury and infection, they can result in highly dangerous, polymicrobial infections in affected patients. Read More

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October 2018

Sarcomatoid cancer of penis in a 45 year old male.

Urology 2018 Nov 26. Epub 2018 Nov 26.

Dept of Pathology, PGIMER, Chandigarh.

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November 2018

Penoscrotal lymphangioma circumscriptum following circumcision.

Turk J Urol 2018 Sep 1;44(5):437-440. Epub 2018 Sep 1.

Department of General Surgery, Post Graduate Institute of Medical Education And Research (PGIMER), Chandigarh, India.

We present a 15 year old boy with multiple vesicular lesions involving the scrotum and penile skin which developed following circumcision. Surgical excision of the penoscrotal skin with local flap cover was done. Histopathology was consistent with lymphangioma circumscriptum. Read More

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September 2018

MyD88 overexpression deteriorates Ang-II-induced ED via upregulating MPO and COX2 and downregulating eNOS in the corpus cavernosum of rats.

J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.

Department of Urology, China-Japan Union Hospital of Jilin University, Changchun, China.

Introduction: Erectile dysfunction (ED) is a common sexual problem for men and the exploration of its treatment is still in mire demand. We aim to investigate the role of the Toll-like receptor 4 (TLR4)/myeloid differentiation primary response gene 88 (MyD88) signaling pathway in the pathogenesis of angiotensin II (Ang-II) induced ED.

Methods: Male Sprague-Dawlay rats were treated with Ang-II and intracavernous pressure (ICP) was measured to confirm the occurrence of ED. Read More

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November 2018

Erythematous Papule on the Glans Penis.

JAMA Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pathology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain.

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November 2018

Thalidomide in plasma cell balanitis refractory to conventional topical treatment.

An Bras Dermatol 2018 Nov/Dec;93(6):881-883

Department of Dermatopathology, Hospital Santa Casa de Misericórdia de Vitória, Vitória (ES), Brasil.

Zoon's plasma cell balanitis is a chronic genital inflammatory dermatosis that affects uncircumcised men, especially the elderly. It's characterized by painless erythematous plaques of orange hue, located on the glans penis and foreskin. Circumcision is the most effective treatment; however, it can be hard for patients to accept. Read More

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August 2017
3 Reads

Increased risk of second cancers at sites associated with HPV after a prior HPV-associated malignancy, a systematic review and meta-analysis.

Br J Cancer 2018 Nov 28. Epub 2018 Nov 28.

MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, 90 High Holborn, London, UK.

Background: High-risk human papilloma viruses (HPV) are a causative agent of anogenital and oropharyngeal cancers. Patients treated for a preinvasive or invasive HPV-associated cancer may be at increased risk of a second such malignancy.

Methods: We performed a systematic review and random effects meta-analysis to estimate the risk of HPV-associated cancer after prior diagnosis. Read More

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November 2018

The biomechanical properties of the urethra in boys with hypospadias: a preliminary study.

J Pediatr Urol 2018 Sep 19. Epub 2018 Sep 19.

Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Blvd. 82, DK-8200 Aarhus N, Denmark; Department of Urology, Section of Paediatric Urology, Aarhus University Hospital, Palle Juul-Jensens Blvd. 99, DK-8200 Aarhus N, Denmark.

Purpose: The ventral aspect of the penis in boys with hypospadias is composed of dysplastic tissue of the skin and the urethra. The aim of this study was to assess the pre-operative size and biomechanical properties of urethrae in boys with and without hypospadias using a more objective catheter-based system.

Materials & Methods: In this non-blinded clinical observation study, the study population consisted of 19 boys with hypospadias-the case group (median age 13. Read More

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September 2018