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    2287 results match your criteria Penile Squamous Cell Carcinoma

    1 OF 46

    Lymphangioma Circumscriptum Post Radiotherapy for Penile Cancer Treated with CO₂ Laser.
    Acta Dermatovenerol Croat 2018 Apr;26(1):53-57
    Ancuta Proca Nicula, MD, PhD student, "Victor Babes" University of Medicine and Pharmacy, Dermatology Department, Eftimie Murgu No 2, 300041 Timisoara, Romania;
    Lymphangioma circumscriptum (LC) is a rare, benign condition, predominantly characterized by the malformation of lymphatic skin vessels. Its onset may be congenital or due to secondary causes such as radiotherapy, infections, or surgical procedures. We present the case of a 55-year-old patient with a pathologic history of squamous cell carcinoma of the penis followed by radical penectomy. Read More

    Penile squamous cell carcinoma with urethral extension treated with Mohs micrographic surgery.
    Cutis 2018 Apr;101(4):E15-E18
    Dermatology, MedStar Georgetown University Hospital/Washington Hospital Center, Washington, DC, and private practice, Chevy Chase, Maryland, USA.
    Penile squamous cell carcinoma (SCC) with considerable urethral extension is uncommon and difficult to manage. It often is resistant to less invasive and nonsurgical treatments and frequently results in partial or total penectomy, which can lead to cosmetic disfigurement, functional issues, and psychological distress. We report a case of penile SCC in situ with considerable urethral extension with a focus of cells suspicious for moderately well-differentiated and invasive SCC that was treated with Mohs micrographic surgery (MMS). Read More

    Robotic-assisted inguinal lymphadenectomy: a systematic review.
    J Robot Surg 2018 May 5. Epub 2018 May 5.
    Gynaecological Oncology Department, Northampton General Hospital, Northampton, UK.
    Background: Lymphadenectomy represents the standard treatment for various types of cancer. The introduction of robotics in lymph node dissection may have an important impact on post-lymphadenectomy complications.

    Methods: A systematic literature review was performed. Read More

    Genital Lichen Sclerosus Et Atrophicus: A Benign Skin Disorder with Malignant Aftermath.
    Urology 2018 May 2. Epub 2018 May 2.
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:
    Genital lichen sclerosus et atrophicus is an uncommon genital dermatosis. Its resemblance to vitiligo especially during the earlier stages leads to delay in its diagnosis. Apart from the common complications such as meatal stenosis, balanoposthitis, phimosis and painful erections, squamous cell carcinoma (SCC) is a rare but ominous complication of genital LSA. Read More

    Invasive penile squamous cell carcinoma.
    Cutis 2018 Mar;101(3):224-227
    Department of Laboratory Medicine, Department of Dermatology, Geisinger Medical Center, Danville, Pennsylvania, USA.
    Invasive penile squamous cell carcinoma (PSCC) is a rare malignancy with considerable morbidity and mortality. Because a delayed or incorrect diagnosis can have a devastating outcome, physicians should maintain a high index of clinical suspicion for PSCC in patients presenting with penile lesions, particularly in young or middle-aged patients in whom presentation of PSCC is uncommon. We report the case of a 27-year-old circumcised man who presented with invasive PSCC following a diagnosis of condyloma 8 years prior. Read More

    Risks and Benefits of Adjuvant Radiotherapy After Inguinal Lymphadenectomy in Node-positive Penile Cancer: A Systematic Review by the European Association of Urology Penile Cancer Guidelines Panel.
    Eur Urol 2018 Apr 24. Epub 2018 Apr 24.
    Department of Medical Oncology, Foundation IRCCS-National Institute Dei Tumori, Milan, Italy.
    Context: Management of men with penile squamous cell carcinoma (PSCC) who have high-risk features following radical inguinal lymphadenectomy (ILND) remains controversial. European Association of Urology guidelines state that adjuvant inguinal radiotherapy (AIRT) is "not generally recommended". Despite this, many centres continue to offer AIRT to a subset of men. Read More

    A neglected reddish penile patch: A wolf in sheep's clothing.
    Indian J Urol 2018 Apr-Jun;34(2):155-157
    Department of Urology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Microinvasive squamous cell carcinoma (SCC) is a known premalignant lesion of carcinoma cervix. It is also reported from other sites such as the oral cavity, larynx, and vulva. Microinvasive SCC is very rarely reported from the penis. Read More

    [A Case of Sarcomatoid Squamous Cell Carcinoma of the Penis].
    Hinyokika Kiyo 2018 Feb;64(2):79-82
    The Department of Urology, Asahikawa Red Cross Hospital.
    A 74-year-old man presented to our hospital with the swelling of penis in May 2016. Physical examination revealed a goose egg-sized lump at the tip of the penis under foreskin. After dorsal skin incision we confirmed the 7 cm tumor on the inner preputial skin and then resected the tumor with circumcision. Read More

    Biallelic TP53 gain of function mutations in rapidly progressing solid tumors.
    Cancer Genet 2018 Apr 24;222-223:20-24. Epub 2018 Feb 24.
    Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City 52241, IA, USA . Electronic address:
    Recent studies are discovering TP53 mutations with gain of function (GOF) properties that promote tumorigenesis via a variety of mechanisms. To our knowledge, all reported compound mutations are allelic. We identified two patients with biallelic GOF TP53 mutations in their tumors and a third with allelic compound variants. Read More

    Analysis of the PI3K-AKT-mTOR pathway in penile cancer: evaluation of a therapeutically targetable pathway.
    Oncotarget 2018 Mar 23;9(22):16074-16086. Epub 2018 Mar 23.
    Centre for Molecular Oncology, Bart's Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
    Objectives: To determine whether phosphatidylinositol-4,5-bisphosphate 3- kinase, catalytic subunit alpha (PIK3CA) copy number gain is common and could prove a useful marker for the activation status of the PI3K-AKT-mTOR pathway in penile squamous cell carcinoma (PSCC).

    Methods: Fresh frozen tissue and archival blocks were collected from 24 PSCC patients with 15 matched normal penile epithelium (NPE) tissue from St George's Hospital. PIK3CA mutational and copy number status (CNS) was assessed via Sanger sequencing and fluorescence hybridisation, respectively. Read More

    Minimizing Post-operative Complications of Groin Dissection Using Modified Skin Bridge Technique: A Single-Centre Descriptive Study Showing Post-operative and Early Oncological Outcomes.
    World J Surg 2018 Apr 13. Epub 2018 Apr 13.
    Department of Surgical Oncology, Dr BRA-IRCH, All India Institute of Medical Sciences, New Delhi, India.
    Introduction: Historically, groin dissections are associated with high morbidity. Various modifications have been described in the literature with inconsistent outcomes. The aim of this paper is to highlight modified skin bridge technique to minimize all post-operative complications of groin dissection without compromising early oncological outcomes. Read More

    Reconstruction of a Giant Wound Induced by Advanced Penile Carcinoma with Bilateral Anteromedial Thigh Flap and Left Deep Circumflex Iliac Artery Flaps.
    World J Plast Surg 2018 Jan;7(1):118-121
    Department of Plastic Surgery, Sun Yat-sen Memorial Hosptial, Sun Yat-sen University, Guangzhou, China.
    A 39-year-old male patient presented with an extensive putrescent ulceration of abdominoperineal region infiltrated by advanced penile squamous cell carcinoma. To our knowledge, it is the largest defect after aggressive palliative resection of penile squamous cell carcinoma (pSCC) in the literature, which was 36×23 cm. The defect was divided into three sub-defects, and was repaired by bilateral anteromedial thigh (AMT) and left deep circumflex iliac artery (DCIA) flaps. Read More

    Nonvenereal Penile Dermatoses: A Retrospective Study.
    Indian Dermatol Online J 2018 Mar-Apr;9(2):96-100
    University Clinic of Dermatology, Hospital de Santa Maria, Lisbon, Portugal.
    Context: A variety of nonvenereal diseases can affect the penis and diminish quality of life. Many present similar clinical features and a cutaneous biopsy may be necessary to clarify the diagnosis.

    Aims: To characterize nonvenereal penile dermatoses with histological confirmation in a southwestern Europe hospital during a 9-year period. Read More

    Evidence for Efficacy of Treatment With the Anti-PD-1 Mab Nivolumab in Radiation and Multichemorefractory Advanced Penile Squamous Cell Carcinoma.
    J Immunother 2018 Apr 10. Epub 2018 Apr 10.
    OncoDNA SA, Gosselies, Belgium.
    Penile squamous cell carcinoma (PeSCC) is a rare tumor and advanced PeSCC is associated with poor survival due to the aggressiveness of the disease and lack of effective systemic therapies. We describe for the first time a case with advanced chemoradiation refractory PeSCC who had documented response to active immunotherapy with the immune checkpoint inhibitor, anti-programmed death-1 monoclonal antibody Nivolumab. The patient suffered from a poor prognosis human papillomavirus-negative PeSCC, with a somatic inactivation mutation of cyclin-dependent kinase inhibitor 2A (CDKN2A) gene in tumor cells, and treatment with Nivolumab resulted in a partial response to therapy and significant tumor shrinkage. Read More

    Genitogluteal porokeratosis in an HIV-positive man: a case report and review of the literature on genital porokeratosis.
    Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
    Department of Dermatology, University of California San Diego, La Jolla, California.
    Genitogluteal porokeratosis is a disorder of keratinization that may present in men in their fourth decade of life. We describe a 52-year-old human immunodeficiency virus (HIV)-positive man with history of anal squamous cell carcinoma who developed verrucous lesions on the buttocks and genitals. The buttock lesions presented shortly after radiotherapy for anal carcinoma a decade prior, whereas the genital lesions presented three months prior in areas treated with injectable medication for erectile dysfunction. Read More

    A study into the association between local recurrence rates and surgical resection margins in organ-sparing surgery for penile squamous cell cancer.
    BJU Int 2018 Mar 31. Epub 2018 Mar 31.
    Department of Urology, St George's Hospital, London, UK.
    Objective: To evaluate the significance of close surgical margins in organ-sparing surgery (OSS) in the treatment of penile squamous cell carcinoma (pSCC) and clinicopathological factors that may influence local recurrence.

    Patients And Methods: At our tertiary referral centre, between March 2001 and September 2012, 332 patients treated with OSS for pSCC had clear surgical margins. As the focus was the impact of close clear margins on local recurrence, patients with positive margins were excluded for the purpose of this study. Read More

    The relationship between HPV status and chemoradiotherapy in the locoregional control of penile cancer.
    World J Urol 2018 Mar 27. Epub 2018 Mar 27.
    Department of Radiation Oncology, H Lee Moffitt Cancer Center and Research Institute, 12902 USF Magnolia Dr, Tampa, FL, 33612, USA.
    Background: Penile cancer (PeCa) is a rare, aggressive malignancy often associated with the human papillomavirus (HPV). The practice of a personalized risk-adapted approach is not yet established. This study is to assess the relationship between HPV tumor status and chemoradiotherapy (CRT) in PeCa locoregional control (LRC). Read More

    Testicular germ-cell tumours and penile squamous cell carcinoma: Appropriate management makes the difference.
    Eur J Surg Oncol 2018 Feb 14. Epub 2018 Feb 14.
    Evaluative Epidemiology Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy.
    Germ-cell tumours (GCT) of the testis and penile squamous cell carcinoma (PeSCC) are a rare and a very rare uro-genital cancers, respectively. Both tumours are well defined entities in terms of management, where specific recommendations - in the form of continuously up-to-dated guide lines-are provided. Impact of these tumour is relevant. Read More

    [Penile cancer: diagnosis and staging].
    Urologe A 2018 Apr;57(4):418-422
    Urologische Klinik und Poliklinik, Universitätsmedizin Rostock, Ernst-Heydemann-Str. 6, 18057, Rostock, Deutschland.
    Penile cancer is often an obvious visual diagnosis but histologic verification should be obtained prior to treatment. The clinical examination should determine the tumor stage and whether it has infiltrated the cavernous bodies and/or the urethra and it should adequately assess the inguinal lymph nodes. Preoperative imaging of the lesion is only indicated in equivocal cases. Read More

    Treatment Trends and Outcomes for Patients With Lymph Node-Positive Cancer of the Penis.
    JAMA Oncol 2018 Mar 1. Epub 2018 Mar 1.
    Department of Hematology/Oncology, Fox Chase Cancer Center, Temple Health, Philadelphia, Pennsylvania.
    Importance: Penile cancer is an uncommon disease with minimal level I evidence to guide therapy. The National Comprehensive Cancer Network (NCCN) guidelines advocate a lymph node dissection (LND) or radiotherapy with consideration of perioperative chemotherapy for all patients with lymph node-positive (LN+) penile cancer without metastasis.

    Objectives: To determine temporal trends in use of chemotherapy for patients with LN+ penile cancer without metastasis and to evaluate outcomes between those who did or did not receive LND, chemotherapy, and radiotherapy. Read More

    [Human papillomavirus and penile cancer : Thinking about measures for prevention].
    Urologe A 2018 Apr;57(4):413-417
    Klinikum der Universität München, Großhadern, München, Deutschland.
    Two major pathways of penile carcinogenesis are known: human papillomavirus (HPV)-induced penile cancer and HPV-negative cancers associated with chronic dermatoses. Therefore, modern measures for prevention of penile cancer may for example include prophylactic HPV vaccination. The resulting B‑cell-mediated immunity to HPV capsid proteins is effective protection against future HPV infections. Read More

    Simultaneous Occurrence of Balanoposthitis Circumscripta Plasmacellularis Zoon, Phimosis and Carcinoma of the Penis: Case Report with An Unusual Ulcerated Polypoid Variant of Zoon's Disease and a Carcinoma of Reserve Cell Type.
    Open Access Maced J Med Sci 2018 Jan 31;6(1):61-63. Epub 2017 Dec 31.
    Università Degli Studi "G. Marconi", Rome, Italy.
    Background: Zoon's balanitis is a benign disease characterized by an asymptomatic, chronic, solitary, shiny, red-orange plaque of the glans and/ or prepuce. In rare cases of Zoon's disease, penile squamous cell carcinoma developed in the chronic inflammatory lesions.

    Case Report: We report on a 68-year-old male patient presenting with phimosis and coexistent Zoon's disease and penile carcinoma in situ treated successfully by circumcision. Read More

    Long-term incidence trends of HPV-related cancers, and cases preventable by HPV vaccination: a registry-based study in Norway.
    BMJ Open 2018 02 23;8(2):e019005. Epub 2018 Feb 23.
    Department of Research, Cancer Registry of Norway, Oslo, Norway.
    Objectives: Examine long-term incidence trends of human papillomavirus (HPV)-related cancer in Norway, and estimate the number of cancer cases preventable by vaccines against HPV 16/18 or HPV 16/18/31/33/45/52/58.

    Design: Observational registry-based study. We extracted incident cases of HPV-related cancer during 1953-2015 from the Cancer Registry of Norway. Read More

    [Molecular characterization of penile cancer : Literature review of new prognostic markers and potential therapeutic targets].
    Urologe A 2018 Apr;57(4):398-407
    Urologische Klinik, Caritas-Krankenhaus St. Josef, Universität Regensburg, Regensburg, Deutschland.
    Squamous cell carcinoma of the penis (SCCP) is a rare cancer type in Western industrialized nations; nevertheless, it shows an aggressive course of disease in advanced tumor stages with accordantly high recurrence and progression rates. While molecular biomarkers are not established in clinical routine for the management of SCCP patients yet, the accordant unmet need is enormous, as adequate biomarkers would be meaningful for prognostic determination, planning of modality and extent of primary therapy, indication for inguinal lymph node resection, adjuvant treatment, and as potential targets for specific systemic treatment. SCCP regularly develops from a precursor lesion. Read More

    [Pathology and histopathological evaluation of penile cancer].
    Urologe A 2018 Apr;57(4):391-397
    Institut für Pathologie, Universitätsmedizin Rostock, Strempelstraße 14, 18057, Rostock, Deutschland.
    Background: Penile cancer is rare in Germany and in western European countries. Our understanding of the pathogenesis and pathology of this malignancy has increased considerably in recent years.

    Objectives: Clinical management has become more complex, with organ-preserving strategies being increasingly favored. Read More

    Giant genital warts.
    Clin Case Rep 2018 Feb 5;6(2):444-445. Epub 2018 Jan 5.
    2nd Department of SurgerySchool of MedicineAretaieion University HospitalNational and Kapodistrian University of Athens University of Athens76 Vassilisis Sofia's AveAthens11528Greece.
    Genital warts are quite common and should be treated early with nonaggressive conservative or invasive methods. When they are severely neglected patients may be submitted to amputative surgical management. Preoperatively malignant transformation of the tumors cannot be excluded. Read More

    Surgical and Oncological Outcomes in Patients After Vascularised Flap Reconstruction for Locoregionally Advanced Penile Cancer.
    Eur Urol Focus 2018 Feb 9. Epub 2018 Feb 9.
    Department of Urology, Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:
    Background: Treatment of locoregionally advanced penile squamous cell carcinoma (LAPSCC) is challenging. The exact role (in terms of oncological benefit) of extensive surgery is not well established. Moreover, surgery invariably leads to large defects requiring reconstructive surgery. Read More

    Pulsed-dye laser therapy for carcinoma in situ of the penis.
    Br J Dermatol 2018 Jan 24. Epub 2018 Jan 24.
    Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
    Carcinoma in situ (CIS) of the penis is a precancerous condition with a 5 to 10% risk for progression into an invasive penile squamous cell carcinoma (SCC) . Clinical variants of genital CIS encompass bowenoid papulosis, erythroplasia of Queyrat and Bowen's disease. Treatment options of penile CIS include topical application of 5-fluorouracil (5-FU) or imiquimod, photodynamic therapy (PDT), ablative laser therapy, cryotherapy and surgery . Read More

    "Double trouble" - synchronous mantle cell lymphoma and metastatic squamous cell carcinoma in an inguinal lymph node.
    Pol J Pathol 2017;68(3):270-274
    Multiple primary neoplasms may also occur synchronously. Lymphoma may coexist with second malignant tumor in its primary location or malignant tumor may metastases to lymphomatous lymph nodes. Most often lymphoid component is a low grade lymphoma and coexistence of mantle cell lymphoma (MCL) and second malignant tumor is much rarer. Read More

    Validation of predictors for lymph node status in penile cancer: Results from a population-based cohort.
    Can Urol Assoc J 2018 Apr 22;12(4):119-125. Epub 2017 Dec 22.
    Department of Oncology, Queen's University, Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston, ON.
    Introduction: The ability to predict lymph node (LN) status is essential in the management of men with localized squamous cell carcinoma (SCC) of the penis. There has been limited external validation of available risk stratification tools, particularly in routine clinical care. The objective of this study was to evaluate the predictive variables of LN metastases within a large population-based cohort of patients. Read More

    Histological subtype is a significant predictor for inguinal lymph node metastasis in patients with penile squamous cell carcinoma.
    Asian J Androl 2018 May-Jun;20(3):265-269
    Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.
    The present study aimed to investigate the relationship between histopathological subtype and the probability of inguinal lymph node metastasis (ILNM) in patients with penile squamous cell carcinoma (PSCC). The clinical records of 198 consecutive patients with PSCC were analyzed retrospectively. Primary lesions were reevaluated according to the 2016 World Health Organization (WHO) histopathological classification. Read More

    Racial disparity and survival outcomes between African-American and Caucasian American men with penile cancer.
    BJU Int 2018 May 22;121(5):758-763. Epub 2018 Jan 22.
    Department of Urology, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
    Objective: To determine whether there is a survival difference for African-American men (AAM) versus Caucasian American men (CM) with penile squamous cell carcinoma (pSCC), particularly in locally advanced and metastatic cases where disease mortality is highest.

    Patients And Methods: Using the Florida Cancer Data System, we identified men with pSCC from 2005 to 2013. We compared age, follow-up, stage, race, and treatment type between AAM and CM. Read More

    Differences in Survival Associated with Performance of Lymph Node Dissection in Patients with Invasive Penile Cancer: Results from the National Cancer Database.
    J Urol 2018 May 15;199(5):1238-1244. Epub 2017 Dec 15.
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
    Purpose: Inguinal lymphadenectomy remains under performed in patients with invasive penile cancer. Using a large national cancer registry we assessed temporal trends in inguinal lymphadenectomy performance and evaluated the impact of the procedure on survival in patients in whom inguinal lymphadenectomy was an absolute indication (T1b-4 N0/x-1) according to NCCN (National Comprehensive Cancer Network®) Guidelines®.

    Materials And Methods: We queried the National Cancer Database for all cases of nonmetastatic, T1b-4 N0/x-1 squamous cell carcinoma of the penis from 2004 to 2014. Read More

    Trends in incidence, mortality and survival of penile squamous cell carcinoma in Norway 1956-2015.
    Int J Cancer 2018 Apr 15;142(8):1586-1593. Epub 2017 Dec 15.
    Department of Research, Cancer Registry of Norway, Oslo, Norway.
    We examine trends in incidence, mortality and survival of penile squamous cell carcinoma (SCC) in Norway over 60 years. Data on all cases of penile cancer diagnosed in Norway during 1956-2015 were obtained from the Cancer Registry of Norway. Trends in age-standardized rates of penile SCC incidence, mortality and 5-year relative survival were assessed by the annual percentage change statistic and joinpoint regression. Read More

    Thulium-yttrium-aluminium-garnet (Tm:YAG) laser treatment of penile cancer: oncological results, functional outcomes, and quality of life.
    World J Urol 2018 Feb 2;36(2):265-270. Epub 2017 Dec 2.
    Department of Urology, Istituto Europeo di Oncologia, Via Ripamonti 435, Milan, Italy.
    Purpose: To evaluate the oncological and functional outcomes of patients diagnosed with penile cancer undergoing conservative treatment through thulium-yttrium-aluminium-garnet (Tm:YAG) laser ablation.

    Methods: Twenty-six patients with a penile lesion underwent ablation with a RevoLix 200 W continuous-wave laser. The procedure was carried out with a pen-like laser hand piece, using a 360 μm laser fiber and 15-20 W of power. Read More

    Combined Partial Penectomy With Bilateral Robotic Inguinal Lymphadenectomy Using Near-infrared Fluorescence Guidance.
    Urology 2018 Mar 27;113:251. Epub 2017 Nov 27.
    Department of Urology, University of Miami Miller School of Medicine, Miami, FL. Electronic address:
    Objective: To describe our novel technique for performing a combined partial penectomy and bilateral robotic inguinal lymphadenectomy using intraoperative near-infrared (NIR) fluorescence guidance with indocyanine green (ICG) and the DaVinci Firefly camera system.

    Methods: A 58-year-old man presented status post recent excisional biopsy of a 2-cm lesion on the left coronal aspect of the glans penis. Pathology revealed "invasive squamous cell carcinoma of the penis with multifocal positive margins. Read More

    Contemporary role of radiotherapy in the management of penile cancer.
    Transl Androl Urol 2017 Oct;6(5):855-867
    British Columbia Cancer Agency, Center for the Southern Interior, Kelowna, BC, Canada.
    Penile cancer is a rare clinical entity that contributes to significant patient morbidity and mortality. Human papilloma virus (HPV) plays an important role in the carcinogenesis of penile squamous cell carcinoma (SCC), is associated with improved clinical outcomes, and is predictive for response to treatment with chemotherapy and radiotherapy. Historically, treatment consisted of radical surgery with partial or total penectomy. Read More

    Beyond chemotherapy for advanced disease-the role of EGFR and PD-1 inhibitors.
    Transl Androl Urol 2017 Oct;6(5):848-854
    Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
    Penile squamous cell carcinoma (SCC) is a rare malignancy with limited treatment options when the tumor is unresectable and/or chemorefractory. Triplet systemic chemotherapy regimens including taxane and cisplatin are recommended, but the response duration can be short and the treatment-related toxicity high. Only a small proportion of patients survive 1 year or longer with the current standard treatment paradigm. Read More

    Robotic inguinal lymphadenectomy for penile cancer: the why, how, and what.
    Transl Androl Urol 2017 Oct;6(5):826-832
    Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL, USA.
    Squamous cell carcinoma of the penis (SCC-P) demonstrates a reliable pattern of spread to the lymph nodes of the groin. High grade and higher stage (pT1b or greater) SCC-P demonstrate a higher propensity for metastasis to the inguinal lymph nodes. Further, lymphadenopathy progresses in a predictable fashion, from superficial inguinal lymph nodes to deep inguinal lymph nodes to pelvic lymph nodes, with limited survival noted for those patients with progression to pelvic lymph nodes. Read More

    Topical Therapy for non-invasive penile cancer (Tis)-updated results and toxicity.
    Transl Androl Urol 2017 Oct;6(5):803-808
    Department of Urology, St George's Hospital, London, UK.
    Penile cancer is a rare malignancy estimated to affect 26,000 men globally each year. The association with penile cancer, in particular non-invasive disease, and human papilloma virus (HPV) is well known. Ninety-five percent of cases of penile cancer are squamous cell carcinoma (SCC), which are staged using the TNM staging system. Read More

    Prevalence of oncogenic human papillomavirus genotypes in patients diagnosed with anogenital malignancies in Botswana.
    BMC Infect Dis 2017 11 25;17(1):731. Epub 2017 Nov 25.
    Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Botswana, Private Bag UB072, 4775 Notwane Rd., Gaborone, Botswana.
    Background: Human papillomavirus (HPV) associated malignancies are the leading cause of cancer death in Botswana. We sought to determine causative HPV types in patients with anogenital malignancies in Botswana to inform vaccine strategy.

    Methods: We used formalin-fixed and paraffin-embedded (FFPE) tissue blocks from patients diagnosed with anal, penile and vulvar squamous cell carcinomas between the years, 2014 and 2016. Read More

    APOBEC3A Expression in Penile Squamous Cell Carcinoma.
    Pathobiology 2017 Nov 23. Epub 2017 Nov 23.
    Section of Molecular Urooncology, Department of Urology, Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, Germany.
    Background: APOBECs (apolipoprotein B mRNA-editing catalytic polypeptides) are cytidine deaminases that have been implicated in the host defense against viruses by blocking viral replication. They have also been shown to play a role in genome hypermutation in several human cancers. An APOBEC3 hypermutation signature has been discovered in cervical cancer, which is intimately associated with infection by high-risk human papillomaviruses (HPVs). Read More

    Video Endoscopic Inguinal Lymphadenectomy vs Open Inguinal Lymphadenectomy for Carcinoma Penis: Expanding Role and Comparison of Outcomes.
    Urology 2018 Mar 16;113:79-84. Epub 2017 Nov 16.
    Department of Urology and Renal Transplantation, SMS Medical College, Jaipur, Rajasthan, India.
    Objective: To compare differences of morbidity profile, oncological yield, and efficacy between video endoscopic inguinal lymphadenectomy and open inguinal lymphadenectomy cases.

    Materials And Methods: A total of 29 patients with proven squamous cell carcinoma of the penis were selected for inguinal lymphadenectomy from August 2013 to January 2017. Video endoscopic lymphadenectomy was performed on 1 limb and open inguinal lymphadenectomy was performed on the contralateral side. Read More

    Penile warty mucoepidermoid carcinoma with features of stratified mucin-producing intra-epithelial lesion and invasive stratified mucin-producing carcinoma.
    Histopathology 2018 Apr 14;72(5):867-873. Epub 2018 Jan 14.
    Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Pilsen, Czech Republic.
    Aims: Stratified mucin-producing intra-epithelial lesion (SMILE) and invasive stratified mucin-producing carcinoma (ISMC) are recently described cervical and penile lesions. We report an unusual case of mixed variant of penile squamous cell carcinomas with warty, usual and mucoepidermoid SMILE/ISMC features.

    Methods And Results: A 62-year-old Japanese man had a glans penis lesion of one-and-a-half years' duration, suggesting malignancy. Read More

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