Am J Surg Pathol 2017 Sep 15. Epub 2017 Sep 15.

*Pathology and Research Institute †School of Medicine, National University of Asunción, Asunción, Paraguay.

Adipose tissue, along with arteries, veins, and peripheral nerves, is a normal constituent of mesenchymal tissues encasing the corpora cavernosa at the level of the penile shaft, variously designated as penile fascia or Bucks fascia. To our knowledge, the presence of fat has not been previously reported within the corpora cavernosa. One or 2 transversal histologic sections at the level of the surgical margin at the shaft of 63 consecutive partial penectomy specimens for squamous cell carcinoma were evaluated. Read More

BJU Int 2017 Sep 16. Epub 2017 Sep 16.

Department of Surgery Urology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori.

Objective: To harness the frontline therapy in advanced penile squamous cell carcinoma (PSCC), for which chemotherapy exerts moderate activity but poor efficacy. Dacomitinib is an irreversible, pan-epidermal growth factor receptor (HER) inhibitor.

Patients And Methods: In a phase 2 study (NCT01728233), patients received dacomitinib 45 mg/day, orally, continuously. Read More

J Clin Diagn Res 2017 Jul 1;11(7):PD17-PD18. Epub 2017 Jul 1.

Head, Department of Urology, Sri Sathya Sai Institute of Higher Medical Sciences, Prashantigram, Ananthpur, Andhra Pradesh, India.

Penile carcinoma is considered a delayed sequel of lichen sclerosus. It is important to recognize this not so uncommon complication in time as survival of patients with Squamous Cell Carcinoma (SCC) depends on early diagnosis and treatment. We describe a case of a 49-year-old male presenting with urethral stricture due to lichen sclerosus. Read More

Urol Oncol 2017 Sep 4. Epub 2017 Sep 4.

Department of Urology, University College London Hospital, London, UK; NIHR Biomedical Research Centre at University College London Hospitals, London, UK. Electronic address:

Objectives: To investigate predictive pathological factors for local recurrence (LR) after glansectomy for penile squamous cell carcinoma (SCC) and to develop a risk score for prediction of LR after glansectomy.

Patients And Methods: In this retrospective study, we analyzed 117 patients operated between February 2005 and January 2016 in a supraregional penile cancer center in the UK for LR after glansectomy and glans reconstruction. Univariate and multivariate Cox proportional hazards regression was used to identify 4 prognostic indicators for LR. Read More

Oncotarget 2017 Aug 16;8(31):51542-51550. Epub 2017 May 16.

Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.

Purpose: In this study, we assess the CK2α expression in human penile squamous cell carcinoma (SCC) and its clinical significance.

Methods: A total of 157 human penile SCC tissue samples were immunohistochemically analyzed. In addition, 12 human penile SCC and adjacent normal tissues were examined for CK2α protein and mRNA expression by Western blotting and real-time quantitative PCR, respectively. Read More

Clin Genitourin Cancer 2017 Aug 12. Epub 2017 Aug 12.

Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL.

Background: We analyzed the trends in presentation of squamous cell carcinoma (SCC) of the penis and determined the socioeconomic predictors for locally advanced (cT3-cT4) disease in the United States.

Patient And Methods: The National Cancer Database was queried for patients with clinically nonmetastatic penile SCC and staging available from 1998 to 2012. Temporal trends per tumor stage were evaluated, and a multivariable logistic regression model was used to identify predictors for advanced presentation during the study period. Read More

Int J STD AIDS 2017 Jan 1:956462417728856. Epub 2017 Jan 1.

1 General and Digestive Surgery Unit, 16689 Hospital de la Santa Creu i Sant Pau , Carrer Sant Antoni Maria Claret, Universidad Autónoma de Barcelona, Barcelona, Spain.

Vaginoplasty by penile and scrotal skin inversion is a well-established technique for male-to-female gender confirmation surgery. In this setting, chronic inflammation and lacerations associated with history of human papillomavirus (HPV) infection may induce a high risk of malignant degeneration in the long term. A 78-year-old transgender woman was admitted with genital discomfort and neovaginal discharge. Read More

Urology 2017 Aug 14. Epub 2017 Aug 14.

Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

Objective: To analyze the recurrence and survival outcomes of glansectomy in patients with penile squamous cell carcinoma.

Materials And Methods: We performed a retrospective review of 410 patients across 5 international tertiary referral centers between 1999 and 2016. All patients had tumors involving the glans penis and underwent glansectomy as primary treatment. Read More

Int J Mol Sci 2017 Aug 16;18(8). Epub 2017 Aug 16.

Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA.

Penile cancer (PeCa) is a rare malignancy with potentially devastating effects. Squamous cell carcinoma is the most common variant with distinct precancerous lesions before development into invasive disease. Involvement of the inguinal lymph nodes is the most important prognostic factor in PeCa, and once disease is present outside the groin, prognosis is poor. Read More

J Am Anim Hosp Assoc 2017 Sep/Oct;53(5):277-280. Epub 2017 Aug 9.

From the University of Florida, Gainesville, Florida (V.J., C.H.d.M.S.); Hôpital Vétérinaire Rive-Sud, Brossard, Quebec, Canada (L-P.d.L.); IPEV, Rio de Janeiro, Brazil (E.d.T-P.).

Squamous cell carcinoma of the penis was diagnosed by incisional biopsy of a penile mass in a 12 yr old intact male beagle dog presenting with hemorrhagic discharge from the prepuce. Penile amputation, orchiectomy with scrotal ablation, and scrotal urethrostomy were performed. Hypertrophic osteopathy secondary to pulmonary metastatic disease occurred 10 mo after the surgery. Read More

Clin Genitourin Cancer 2017 Jul 14. Epub 2017 Jul 14.

Department of Urology, Skåne University Hospital, Malmö, Sweden; Department of Translational Medicine, Lund University, Malmö, Sweden.

Eur Urol Focus 2017 Mar 1. Epub 2017 Mar 1.

Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Centre, Rostock, Germany. Electronic address:

Background: For penile cancer (PC) there are no known molecular predictors of lymphatic spread and/or chemoresistance.

Objective: To identify functional biomarkers that can predict malignant progression and treatment responsiveness.

Design, Setting, And Participants: We used four patient-derived PC cell lines and measured invasion and capillary tube formation, chemoresponsiveness, and mRNA and protein expression. Read More

Eur Urol Focus 2016 Aug 27. Epub 2016 Aug 27.

Department of Medicine, Section of Oncology, UAB School of Medicine, Birmingham, AL, USA. Electronic address:

In men with advanced penile squamous cell carcinoma receiving first-line chemotherapy, visceral metastases (VM) and Eastern Cooperative Oncology Group performance status ≥1 are poor prognostic factors for overall survival (OS). We hypothesized that tumor gene expression profiling may enhance prognostic stratification and identify potential therapeutic targets. In this retrospective study, RNA extracted from macrodissected tumors underwent profiling for the expression of 738 genes using NanoString. Read More

J Eur Acad Dermatol Venereol 2017 Jul 27. Epub 2017 Jul 27.

Department of Dermatology, University College London Hospitals, London, UK.

Introduction: Male genital lichen sclerosus (MGLSc) is an acquired, chronic, inflammatory skin disease that is associated with significant morbidity and squamous cell carcinoma of the penis (PSCC). However, some clinical, diagnostic and management controversies endure, including the relationship with penile intraepithelial neoplasia (PeIN).

Objectives: To clarify clinical presentations, diagnostic approaches, histological findings, response to treatment and the relationship with PeIN. Read More

Actas Dermosifiliogr 2017 Jul 18. Epub 2017 Jul 18.

Servicio de Dermatología, Complejo Asistencial Universitario de Salamanca, Salamanca, España; IBSAL Instituto de Investigación Biomédica de Salamanca, Complejo Asistencial Universitario de Salamanca, Salamanca, España.

The eighth edition of the staging manual of the American Joint Committee on Cancer incorporates important changes in the classification of skin cancers. Coming 40 years after the first edition, the latest manual preserves its specific system for Merkel cell carcinoma and takes into account recent publications on the prognosis of squamous cell carcinoma by defining a completely new T category for this neoplasm. Staging for squamous cell carcinoma considers head and neck tumors (excluding the eyelid) and does not offer solutions for other sites except the vulva, penis, and perianal region. Read More

Oncol Rep 2017 Sep 13;38(3):1327-1340. Epub 2017 Jul 13.

Laboratory of Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece.

Non‑melanoma skin cancer (NMSC) is the most common form of cancer worldwide, comprising 95% of all cutaneous malignancies and approximately 40% of all cancers. In spite of intensive efforts aimed towards awareness campaigns and sun‑protective measures, epidemiological data indicate an increase in the incidence of NMSC. This category of skin cancers has many common environmental triggers. Read More

Folia Med (Plovdiv) 2017 Jun;59(2):232-237

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Background: Sarcomatoid (spindle cell) squamous cell carcinoma is a rare, highgrade, aggressive tumor consisting of the squamous cell carcinoma admixed with the malignant spindle cell (sarcomatoid) elements. These tumors are relatively uncommon in the genitourinary system and particularly in the penis.

Materials And Methods: Two sarcomatoid squamous cell carcinomas of the penis were diagnosed in our hospital between 2012 and 2015. Read More

Prog Urol 2017 Sep 4;27(10):564-566. Epub 2017 Jul 4.

Department of pathology, hospital Juárez de México, Mexico City, Mexico.

Penile carcinoma is a rare disease that has a wide range of pathology and morbidity. Occurs commonly in the 6th and 7th decades of life. Squamous cell carcinoma (SCC) is the predominant histological type. Read More

Curr Urol Rep 2017 Aug;18(8):62

Virginia Mason Medical Center, Seattle, WA, USA.

Purpose Of Review: Genital dermatology represents a challenge to many providers. Though dermatologic lesions involving the genitalia may present to any of a number of practices, ranging from primary care to urology, gynecology, and dermatology, few training programs provide significant training regarding the diagnosis and management of genital dermatologic lesions. The purpose of this review is to provide urologists with an overview of common genital dermatological lesions that may be encountered in a clinic. Read More

Urol Oncol 2017 Jun 27. Epub 2017 Jun 27.

Department of Urology, Moffitt Cancer Center, Tampa, FL.

Purpose: Few studies have examined the role of radiation therapy in advanced penile squamous cell carcinoma. We sought to evaluate the association of adjuvant pelvic radiation with survival and recurrence for patients with penile cancer and positive pelvic lymph nodes (PLNs) after lymph node dissection.

Materials And Methods: Data were collected retrospectively across 4 international centers of patients with penile squamous cell carcinoma undergoing lymph node dissections from 1980 to 2013. Read More

Am J Surg Pathol 2017 Jun 13. Epub 2017 Jun 13.

*Polytechnic School §School of Medicine, National University of Asunción †Instituto de Patología e Investigación, Asunción, Paraguay ‡DDL Diagnostic Laboratory, Rijswijk, The Netherlands ∥Miraca Life Sciences and Tufts University, Boston, MA.

Laser capture microdissection-polymerase chain reaction (LCM-PCR) supported by p16 was used for the first time to demonstrate human papillomavirus (HPV) DNA in histologically specific penile lesions, which were as follows: squamous hyperplasia (12 lesions, 10 patients), flat lesions (12 lesions, 5 patients), condylomas (26 lesions, 7 patients), penile intraepithelial neoplasia (PeIN) (115 lesions, 43 patients), and invasive squamous cell carcinomas (26 lesions, 26 patients). HPV was detected by whole-tissue section and LCM-PCR. LCM proved to be more precise than whole-tissue section in assigning individual genotypes to specific lesions. Read More

Urol Oncol 2017 Sep 25;35(9):545.e13-545.e18. Epub 2017 May 25.

Programa de Pós-Graduação em Ciências Médicas, Circulating Biomarkers Laboratory, Department of Pathology, Rio de Janeiro State University, Rio de Janeiro, Brazil; Research Coordination, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.

Objectives: We have previously shown the importance of the complement system in differentiating between patients with squamous cell carcinoma of the penis (SCCP) and controls. These patients had low expression of C3a and C4 fragments. Therefore, in this study, we investigated the complement protein C3a as a potential circulating biomarker in these patients by a commercially available enzyme-linked immunosorbent assay (ELISA) test. Read More

Pathol Res Pract 2017 Jun 19;213(6):702-705. Epub 2017 Apr 19.

Department of Anatomic pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan. Electronic address:

Primary adrenal angiosarcoma is an extremely rare vascular tumor. We report a case of a 63-year-old man with a collision tumor of epithelioid angiosarcoma and adrenocortical adenoma of the right adrenal gland. The adrenal tumor was incidentally observed by a preoperative computed tomography (CT) scan of penis squamous cell carcinoma. Read More

Int J Radiat Oncol Biol Phys 2017 Feb 28. Epub 2017 Feb 28.

Brachytherapy Unit, Gustave Roussy, Villejuif, France; Radiotherapy Department, Gustave Roussy, Villejuif, France; Institut de Recherche Biomédicale des Armées, Bretigny-sur-Orge, France; French Military Health Academy, Ecole du Val-de-Grâce, Paris, France. Electronic address:

Purpose: To report the largest experience with brachytherapy as a conservative approach for the treatment of penile carcinoma.

Methods And Materials: We examined the outcomes of 201 patients treated at our institution over 45 years for invasive squamous cell carcinoma of the glans penis by brachytherapy.

Results: With a median follow-up of 10. Read More

Am J Surg Pathol 2017 Jun;41(6):820-832

*Polytechnic School §School of Medicine, National University of Asunción †Instituto de Patología e Investigación, Asunción, Paraguay ‡DDL Diagnostic Laboratory, Rijswijk, The Netherlands ∥Miraca Life Sciences and Tufts University, Boston, MA.

Laser capture microdissection-polymerase chain reaction (LCM-PCR) supported by p16 was used for the first time to demonstrate human papillomavirus (HPV) DNA in histologically specific penile lesions, which were as follows: squamous hyperplasia (12 lesions, 10 patients), flat lesions (12 lesions, 5 patients), condylomas (26 lesions, 7 patients), penile intraepithelial neoplasia (PeIN) (115 lesions, 43 patients), and invasive squamous cell carcinomas (26 lesions, 26 patients). HPV was detected by whole-tissue section and LCM-PCR. LCM proved to be more precise than whole-tissue section in assigning individual genotypes to specific lesions. Read More

World J Mens Health 2017 Apr;35(1):28-33

Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.

Purpose: The aim of this study was to assess the clinicopathologic characteristics of penile cancer, including patterns of therapy, oncologic results, and survival.

Materials And Methods: Between January 2005 and July 2015, 71 patients at 6 institutions who had undergone penectomy or penile biopsy were enrolled. Their medical records were reviewed to identify the mode of therapy, pathology reports, and cancer-specific survival (CSS) rate. Read More

Plast Reconstr Surg Glob Open 2017 Mar 22;5(3):e1269. Epub 2017 Mar 22.

Department of Plastic Surgery, UT MD Anderson Cancer Center, Houston, Tex.; and Department of Urology, UT MD Anderson Cancer Center, Houston, Tex.

Indian J Sex Transm Dis 2017 Jan-Jun;38(1):78-80

Department of STD, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India.

Human immunodeficiency virus (HIV) infections have a high probability of co-infections with Syphilis and hepatitis B virus since they share the common routes of transmission. We report a 41-year-old HIV male (on antiretroviral therapy for the past 6 years) admitted for a complaint of penile ulcer for 2 months. Serology for syphilis and hepatitis B were positive. Read More

Oncotarget 2017 Mar;8(13):21710-21718

Department of Medicine, Section of Oncology, UAB School of Medicine, Birmingham, Alabama, USA.

Penile squamous cell carcinoma (PSCC) is an orphan malignancy with poorly understood biology and suboptimal systemic therapy. Given that kinases may be drivers and readily actionable, we performed comprehensive multiplatform analysis of kinases in PSCC tumor and normal tissue. Fresh frozen tumors were collected from 11 patients with PSCC. Read More

Clin Exp Dermatol 2017 Apr 13. Epub 2017 Apr 13.

Dermatology Department, National Skin Centre, Singapore.

Pseudoepitheliomatous keratotic and micaceous balanitis (PKMB) is an uncommon premalignant condition involving the glans penis. We report the case of an 86-year-old man who presented with phimosis and pain on retracting his foreskin. He had previously undergone circumcision, which revealed a hyperkeratotic plaque with thin mica-like scales involving his glans penis. Read More

Mod Pathol 2017 Jul 7;30(7):1013-1020. Epub 2017 Apr 7.

Institute of Pathology, Medical University of Graz, Graz, Austria.

The majority of penile squamous cell carcinomas is caused by transforming human papilloma virus (HPV) infection. The etiology of HPV-negative cancers is unclear, but TP53 mutations have been implicated. Archival tissues of 108 invasive squamous cell carcinoma from a single pathology institution in a low-incidence area were analyzed for HPV-DNA and p16(ink4a) overexpression and for TP53 mutations by ion torrent next-generation sequencing. Read More

Br J Cancer 2017 Apr 4;116(9):1218-1222. Epub 2017 Apr 4.

Research and Development, DDL Diagnostic Laboratory, Rijswijk, The Netherlands.

Background: Squamous cell scrotal carcinoma (SCSC) is an infrequent skin cancer associated historically with occupational carcinogens. Human papillomavirus (HPV) DNA has been associated with SCSC but there is no definitive proof of its oncogenic role.

Methods: Human papillomavirus-DNA and -E6*I mRNA were analysed in six invasive histologically typed SCSC. Read More

Urol Oncol 2017 Aug 28;35(8):531.e9-531.e14. Epub 2017 Mar 28.

Department of Urology, UH Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, OH; Division of Urology, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH. Electronic address:

Objective: To determine the locoregional management of penile cancer before the introduction of NCCN guidelines and how much shift in practice patterns is required to meet the guidelines.

Methods: The National Cancer Data Base was queried to identify 6,396 patients with squamous cell carcinoma of the penis diagnosed between 2004 and 2013. The cohort was divided into management groups based on the NCCN guidelines: cTa and cTis (cTa/is), pT1 low grade (T1LG), pT1 high grade (T1HG), and pT2 or greater (T234). Read More

Virchows Arch 2017 Jun 27;470(6):695-701. Epub 2017 Mar 27.

Centro para el Desarrollo de la Investigación Científica (CEDIC), Asunción, Paraguay.

Insulin-like growth factor-1 receptor (IGF1R) plays a key role in cell growth and transformation. It is overexpressed in several solid tumors. This study evaluates IGF1R immunoexpression in penile squamous cell carcinoma (SCC). Read More

Asian Pac J Cancer Prev 2017 02 1;18(2):491-494. Epub 2017 Feb 1.

Department of Pathology, the University Teaching Hospital of Lomé, Togo.

Background: Urological cancers are an important public health issue and pose problems with diagnosis and adequate management in developing countries. Our aim was to determine and report epidemiological and histological features of urological cancers in Togo. Materials and methods: A retrospective descriptive study was conducted of cases of urological cancers observed in the laboratory of pathological anatomy of the CHU Tokoin over the last 4 years (2012-2016). Read More

Oncoimmunology 2017 22;6(2):e1269047. Epub 2016 Dec 22.

Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China; State Key Laboratory of Oncology in Southern China, Guangzhou, P.R. China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, P.R. China.

Despite its rare incidence worldwide, penile squamous cell carcinoma (PeSCC) still presents with significant morbidity and mortality due to the limited treatment options for advanced patients, especially those in developing countries. The program death-1 (PD-1)/PD-1 ligand (PD-L1) axis has been demonstrated to play an important role in tumor immune escape, and immunotherapies targeting this pathway have shown great success in certain cancer types. Here, we analyzed the expression pattern of PD-L1 in tumor cells and tumor-infiltrating lymphocytes (TILs) in PeSCC with a multi-center cohort. Read More

Clin Genitourin Cancer 2017 Feb 27. Epub 2017 Feb 27.

UAB Comprehensive Cancer Center, Birmingham, AL.

Background: The prognosis of patients with locally advanced penile squamous-cell carcinoma is primarily related to the extent of lymph node metastases. Surgery alone yields suboptimal results, and there is a paucity of data on these patients' outcomes.

Patients And Methods: This retrospective study evaluated patients who received neoadjuvant or adjuvant chemotherapy from 1990 onward at 12 centers. Read More

An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):42-44

Faculdade de Medicina de São José do Rio Preto (FAMERP) - São José do Rio Preto (SP), Brazil.

We report a 33-year-old male patient diagnosed with erythroplasia of Queyrat. The patient had an erythematous and eroded lesion affecting more than 50% of the glans associated with bleeding and local pain. Despite previous indication of penectomy, he was successfully treated with topical 5-fluorouracil. Read More

Am J Surg Pathol 2017 Apr;41(4):535-540

*Instituto de Patología e Investigación §School of Medicine, National University of Asuncion - UNA, Asunción, Paraguay †Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO)-IDIBELL, L'Hospitalet de Llobregat, Gran Via de l'Hospitalet, Barcelona ‡CIBER Epidemiology and Public Health, Madrid, Spain ∥Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston, TX ¶National Institute of Cancer, Bogotá, Colombia #DDL Diagnostic Laboratory, Rijswijk, The Netherlands.

A third to half of penile invasive squamous cell carcinomas are human papillomavirus (HPV) related. Warty (condylomatous), warty-basaloid, and basaloid carcinomas are the most common subtypes associated with HPV. Less frequent are clear cell and lymphoepithelioma-like carcinomas. Read More

Int Urol Nephrol 2017 Jun 13;49(6):1007-1014. Epub 2017 Mar 13.

, Lucknow, India.

Purpose: To evaluate the role of microvessel density (MVD) in predicting lymph node (LN) metastasis in penile squamous cell carcinoma (PSCC).

Materials And Methods: Records of 266 patients with PSCC were analyzed. Parameters examined were tumor stage, grade, nodal status, intratumoral and peritumoral MVD. Read More

Cytogenet Genome Res 2016 1;150(3-4):185-193. Epub 2017 Mar 1.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Human papillomaviruses (HPV) are responsible for the development of almost all cervical cancers. HPV is also found in 85% of anal cancer and in 50% of penile, vulvar, and vaginal cancers, and they are increasingly found in a subset of head and neck cancers, i.e. Read More

An Bras Dermatol 2017 Jan-Feb;92(1):95-99

Department of Dermatology - State University of New York - Downstate and Veterans Affairs Medical Center - Brooklyn (NY), United States.

The majority of penile carcinoma is squamous cell carcinoma. Although uncommon in the United States, it represents a larger proportion of cancers in the underdeveloped world. Invasive squamous cell carcinoma may arise from precursor lesions or de novo , and has been associated with lack of circumcision and HPV infection. Read More

Clin Exp Dermatol 2017 Apr 20;42(3):360-362. Epub 2017 Feb 20.

Department of Dermatology, University College London Hospitals, London, UK.

Int J Surg Case Rep 2017 19;32:12-15. Epub 2017 Jan 19.

Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, 59046, Saudi Arabia. Electronic address:

Introduction: Inguinal lymph nodes are the frequent sites of metastasis for malignant lymphoma, squamous cell carcinoma of anal canal, vulva and penis, malignant melanoma and squamous cell carcinoma of skin over lower extremities or trunk. Anatomically, endometrial carcinoma is less likely to spread to the superficial or deep inguinal lymph nodes, thus metastatic involvement of these lymph nodes can easily be overlooked.

Case Presentation: Here-in we report a case of a 65-year old Saudi morbid obese female, who presented with left inguinal lymphadenopathy as initial delayed site of metastasis almost 19 months after the initial treatment for FIGO IA endometrial carcinoma. Read More

Rare Tumors 2016 Nov 20;8(4):6651. Epub 2016 Dec 20.

National Taiwan University School of Medicine , Taipei, Taiwan.

Treatment of locally advanced penile squamous cell carcinoma (pSCC) remains highly controversial secondary to disease rarity and lack of prospective randomized controlled trials. The current mainstays of care are multi-modality treatment with neoadjuvant chemotherapy and surgery. However, clinicians often have difficulty making recommendations for patients unable to tolerate chemotherapy or surgery due to scarcity of data to guide clinical decision-making. Read More

Case Rep Pathol 2017 5;2017:2937592. Epub 2017 Jan 5.

Department of Pathology, Manipal College of Medical Sciences, Pokhara, Nepal.

Penile carcinoma frequency varies widely in different parts of the world and comprises 1-10% of all the malignancies in males. Majority of the cases of penile carcinoma are squamous cell carcinoma of penis comprising 60% to 70% of all cases. Warty carcinoma of penis is an unusual neoplasm and a variant of penile squamous cell carcinoma comprising 5%-10% of all the variants. Read More

Cytogenet Genome Res 2016 1;150(3-4):217-226. Epub 2017 Feb 1.

Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

High-risk human papillomaviruses (HPVs) are known to be associated with different anogenital cancers including cervical, anal, penile, and vaginal cancers. They are also found to be responsible for the dramatic increases in oropharyngeal squamous cell carcinoma (OPSCC) observed in the United States and Europe. The model for how high-risk HPVs induce cancer formation comes from studies of cervical cancer which usually involves integration of the HPV into the human genome and subsequent changes due to induced chromosomal instability. Read More

Indian J Surg Oncol 2017 Mar 6;8(1):85-87. Epub 2016 Jun 6.

Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India.

Sarcomatoid carcinomas are biphasic tumours, which occur at any site in the human body. It rarely affects the penis, with only 38 cases being reported in literature. It may be considered as a variant of squamous cell carcinoma or a dedifferentiated tumour. Read More

J Urol 2017 Jun 20;197(6):1387-1395. Epub 2017 Jan 20.

Department of Surgery, University of Melbourne, Heidelberg, Victoria, Australia; Ludwig Institute for Cancer Research, Melbourne, Victoria, Australia.

Purpose: In penile cancer, the optimal diagnostics and management of metastatic lymph nodes are not clear. Advances in minimally invasive staging, including dynamic sentinel lymph node biopsy, have widened the diagnostic repertoire of the urologist. We aimed to provide an objective update of the recent trends in the management of penile squamous cell carcinoma, and inguinal and pelvic lymph node metastases. Read More

PLoS One 2017 23;12(1):e0170353. Epub 2017 Jan 23.

Institute of Pathology, University Medicine of Rostock, Rostock, Germany.

University anatomical-pathological collections represent huge sources of human tissues and preparations from a variety of different diseases. With the help of modern genetic and histological methods, preserved fixed tissues from pathological collections can be used to re-evaluate former diagnoses. We analysed 25 specimens from our pathological collection with ages ranging from 78 to 112 years. Read More