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    1 OF 45

    Penile warty-mucoepidermoid carcinoma with features of stratified mucin-producing intraepithelial lesion and invasive stratified mucin-producing carcinoma.
    Histopathology 2017 Nov 16. Epub 2017 Nov 16.
    Department of Pathology, Charles University, Medical Faculty and, Charles University Hospital Plzen, Alej Svobody 80, 304 60, Pilsen, Czech Republic.
    Aims: Stratified mucin-producing intraepithelial lesion (SMILE) and invasive stratified mucin-producing carcinoma (ISMC) are recently described cervical and penile lesions. We report an unusual case of mixed variant of penile squamous cell carcinomas with warty, usual and mucoepidermoid SMILE/ISMC features.

    Methods And Results: A 62-year-old Japanese man had a glans penis lesion of one and a half years duration, suggesting malignancy. Read More

    Successful downstaging of locally recurrent penile squamous cell carcinoma with neoadjuvant nanosomal docetaxel lipid suspension (NDLS) based regimen followed by curative surgery.
    BMJ Case Rep 2017 Nov 12;2017. Epub 2017 Nov 12.
    Department of Medical Affairs and Clinical Research, Intas Pharmaceuticals Limited, Ahmedabad, India.
    Penile squamous cell carcinoma (pSCC) is a relatively rare disease in Western world but is a significant health problem in developing countries like India. We report here a case of successful multimodality management of recurrent pSCC with pelvic lymphadenopathy in a 56-year-old male patient with poorly controlled diabetes. The patient presented with ulceroproliferative growth over the residual penile stump clinically involving root of penis and with right pelvic lymphadenopathy. Read More

    CD109 expression is upregulated in penile squamous cell carcinoma.
    Oncol Lett 2017 Nov 15;14(5):6012-6016. Epub 2017 Sep 15.
    Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.
    Cluster of differentiation (CD) 109 is a glycosylphosphatidylinositol-anchored cell surface glycoprotein and a co-receptor for transforming growth factor β. The expression of CD109 has been detected in squamous cell carcinoma of the lung, esophagus, skin and gallbladder. The aim of the present study was to evaluate CD109 expression in penile squamous cell carcinoma (PSCC). Read More

    Impact of County Rurality and Urologist Density on the Practice of Inguinal Lymph Node Dissection and Mortality in Patients Diagnosed with Squamous Cell Carcinoma of the Penis.
    Ann Surg Oncol 2017 Nov 6. Epub 2017 Nov 6.
    Urologic Oncology, Department of Urology, Henry Ford Health System, Detroit, MI, USA.
    Background: Inguinal lymphadenectomy (LND) is influential in reducing the mortality of squamous cell carcinoma of the penis (SCCP). We investigated the impact of urologic workforce density (UD) and rural residence (RR) on the practice of LND and mortality of SCCP (SCCP-RM).

    Materials And Methods: UD was determined from the 2014 to 2015 Area Health Resource File data, while RR was determined using the 2003 rural-urban continuum codes. Read More

    The World Health Organization 2016 classification of penile carcinomas: a review and update from the International Society of Urological Pathology expert driven recommendations.
    Histopathology 2017 Nov 3. Epub 2017 Nov 3.
    Department of Cellular Pathology, St George's Healthcare NHS Foundation Trust, London, UK.
    The International Society of Urological Pathology (ISUP) held an expert driven penile cancer conference in Boston in March 2015 which focused on the new WHO classification of penile cancer: HPV-related tumors and histological grading. The conference was preceded by an online survey of the International Society of Urological Pathology members and the results were used to initiate discussions. Because of the rarity of penile tumors, this was not a consensus but an expert driven conference aiming to assist pathologists who do not see these tumor on a regular basis. Read More

    Insight into novel biomarkers in penile cancer: Redefining the present and future treatment paradigm?
    Urol Oncol 2017 Nov 2. Epub 2017 Nov 2.
    Departments of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL. Electronic address:
    Introduction: Biomarkers are increasingly used in the diagnosis and management of various malignancies. Selected biomarkers may also play a role in management of certain cases of penile carcinoma. In this article, we provide an overview of the clinical role of such markers in the management of penile cancer. Read More

    Laser ablation as monotherapy for penile squamous cell carcinoma: A multi-center cohort analysis.
    Urol Oncol 2017 Oct 30. Epub 2017 Oct 30.
    Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL.
    Introduction: Although the trend towards penile sparing therapy is increasing for penile squamous cell carcinoma, outcomes for laser ablation therapy have not been widely reported. We assessed the clinical outcomes of penile cancer patients treated with only laser ablation.

    Materials And Methods: A retrospective review was performed on 161 patients across 5 multi-center tertiary referral centers from 1985 to 2015. Read More

    Benefits of Urologic-Dermatologic Consultations for the Diagnosis of Cutaneous Penile Lesions: A Prospective Study.
    Clin Genitourin Cancer 2017 Oct 5. Epub 2017 Oct 5.
    Department of Urology, Angers University Hospital, Angers, France.
    Introduction: We evaluated the benefits of a specialized consultation created in 2014 for cutaneous penile lesions.

    Materials And Methods: We performed a descriptive prospective study evaluating all patients sent for a monthly urologic-dermatologic consultation at a French university hospital from September 2014 to September 2015 for cutaneous penile lesions. All patients evaluated were included. Read More

    Management of penile cancer in a Singapore tertiary hospital.
    Arab J Urol 2017 Jun 30;15(2):123-130. Epub 2017 Mar 30.
    Tan Tock Seng Hospital, Singapore, Singapore.
    Objectives: To present our experience of managing penile squamous cell carcinoma (SCC) in a tertiary hospital in Singapore and to evaluate the prognostic value of the inflammatory markers neutrophil-lymphocyte ratio (NLR) and lymphocyte-monocyte ratio (LMR).

    Patients And Methods: We reviewed our prospectively maintained Institutional Review Board-approved urological cancer database to identify men treated for penile SCC at our centre between January 2007 and December 2015. For all the patients identified, we collected epidemiological and clinical data. Read More

    Saphenous-sparing laparoscopic inguinal lymphadenectomy.
    Int Braz J Urol 2017 Oct 24;43. Epub 2017 Oct 24.
    San Bassiano Hospital - Urology, Bassano del Grappa, Italy.
    Introduction: Inguinal lymphadenectomy is an integral part in the management of penile cancer. Video endoscopic in-guinal lymphadenectomy (VEIL) is emerging as a minimally invasive treatment to reduce postoperative complications.

    Materials And Methods: 62 years old man underwent glansectomy for a squamous cell carcinoma (pT1b). Read More

    Oral Human Papillomavirus Infection: Differences in Prevalence Between Sexes and Concordance With Genital Human Papillomavirus Infection, NHANES 2011 to 2014.
    Ann Intern Med 2017 Oct 17. Epub 2017 Oct 17.
    From University of Florida, Gainesville, Florida; Baylor College of Medicine and The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas; Harvard Medical School, Boston, Massachusetts; and Weill Cornell Medicine, New York, New York.
    Background: The burden of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is disproportionately high among men, yet empirical evidence regarding the difference in prevalence of oral HPV infection between men and women is limited. Concordance of oral and genital HPV infection among men is unknown.

    Objective: To determine the prevalence of oral HPV infection, as well as the concordance of oral and genital HPV infection, among U. Read More

    Cancer incidence in Germany attributable to human papillomavirus in 2013.
    BMC Cancer 2017 Oct 16;17(1):682. Epub 2017 Oct 16.
    Department of Epidemiology and Health Monitoring, Robert Koch-Institut, Berlin, Germany.
    Background: It is estimated that a total of 120,000 new cancer cases in men and in women in more developed countries could be avoided if exposure to HPV was prevented. We used the nationwide pool of German population-based cancer registry data to estimate the burden of HPV-attributable cancer in this population for the year 2013.

    Methods: Incident cases of cervical cancer, squamous cell carcinoma of the anus, oropharynx (OP), as well as of the vulva, vagina and penis were classified as potentially HPV-associated and identified from the nationwide cancer registry data-pool. Read More

    Evaluating the accuracy of intraoperative frozen section during inguinal lymph node dissection in penile cancer.
    Urol Oncol 2017 Oct 9. Epub 2017 Oct 9.
    Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL.
    Introduction: Inguinal lymph node dissection is an integral part in the management of invasive penile tumors with intraoperative assessment often aiding decision-making during dissection. In this study, we evaluate the diagnostic value of intraoperative frozen section (FS) and analyze clinicopathologic factors that affect its accuracy.

    Material And Methods: We, retrospectively, reviewed 84 patients with squamous cell carcinoma of the penis who underwent inguinal lymph node dissection at our institution. Read More

    [Urethral ectropion may hide a carcinoma!]
    Pan Afr Med J 2017 3;27:249. Epub 2017 Aug 3.
    Université Mohammed V, Faculté de Médecine et de Pharmacie de Rabat, Hopital Ibn Sina, Service d'Urologie B, Rabat, Maroc.
    The incidence of female urethral cancer is rare and accounts for 0.02% of all women's cancers. It is dominated by epidermoid carcinoma, which most commonly develops in the distal portion of the urethra, extending to inguinal lymph nodes. Read More

    Novel Histologic Finding: Adipose Tissue Is Prevalent Within Penile Tunica Albuginea and Corpora Cavernosa: An Anatomic Study of 63 Specimens and Considerations for Cancer Invasion.
    Am J Surg Pathol 2017 Nov;41(11):1542-1546
    *Pathology and Research Institute †School of Medicine, National University of Asunción, Asunción, Paraguay.
    Adipose tissue, along with arteries, veins, and peripheral nerves, is a normal constituent of mesenchymal tissues encasing the corpora cavernosa at the level of the penile shaft, variously designated as penile fascia or Bucks fascia. To our knowledge, the presence of fat has not been previously reported within the corpora cavernosa. One or 2 transversal histologic sections at the level of the surgical margin at the shaft of 63 consecutive partial penectomy specimens for squamous cell carcinoma were evaluated. Read More

    First-line therapy with dacomitinib, an orally available pan-HER tyrosine kinase inhibitor, for locally advanced or metastatic penile squamous cell carcinoma: results of an open-label, single-arm, single-centre, phase 2 study.
    BJU Int 2017 Sep 16. Epub 2017 Sep 16.
    Urology Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
    Objective: To harness the frontline therapy in advanced penile squamous cell carcinoma (PSCC), for which chemotherapy exerts moderate activity but poor efficacy. Dacomitinib is an irreversible, pan-epidermal growth factor receptor (HER) inhibitor.

    Patients And Methods: In a phase 2 study (NCT01728233), patients received dacomitinib 45 mg/day, orally, continuously. Read More

    Squamous Cell Carcinoma Penis in a Case of Urethral Stricture Due to Lichen Sclerosus Balanitis Xerotica Obliterans: A Case Report and Review of Literature.
    J Clin Diagn Res 2017 Jul 1;11(7):PD17-PD18. Epub 2017 Jul 1.
    Head, Department of Urology, Sri Sathya Sai Institute of Higher Medical Sciences, Prashantigram, Ananthpur, Andhra Pradesh, India.
    Penile carcinoma is considered a delayed sequel of lichen sclerosus. It is important to recognize this not so uncommon complication in time as survival of patients with Squamous Cell Carcinoma (SCC) depends on early diagnosis and treatment. We describe a case of a 49-year-old male presenting with urethral stricture due to lichen sclerosus. Read More

    Predictive factors for local recurrence after glansectomy and neoglans reconstruction for penile squamous cell carcinoma.
    Urol Oncol 2017 Sep 4. Epub 2017 Sep 4.
    Department of Urology, University College London Hospital, London, UK; NIHR Biomedical Research Centre at University College London Hospitals, London, UK. Electronic address:
    Objectives: To investigate predictive pathological factors for local recurrence (LR) after glansectomy for penile squamous cell carcinoma (SCC) and to develop a risk score for prediction of LR after glansectomy.

    Patients And Methods: In this retrospective study, we analyzed 117 patients operated between February 2005 and January 2016 in a supraregional penile cancer center in the UK for LR after glansectomy and glans reconstruction. Univariate and multivariate Cox proportional hazards regression was used to identify 4 prognostic indicators for LR. Read More

    More precise prediction in Chinese patients with penile squamous cell carcinoma: protein kinase CK2α catalytic subunit (CK2α) as a poor prognosticator.
    Oncotarget 2017 Aug 16;8(31):51542-51550. Epub 2017 May 16.
    Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.
    Purpose: In this study, we assess the CK2α expression in human penile squamous cell carcinoma (SCC) and its clinical significance.

    Methods: A total of 157 human penile SCC tissue samples were immunohistochemically analyzed. In addition, 12 human penile SCC and adjacent normal tissues were examined for CK2α protein and mRNA expression by Western blotting and real-time quantitative PCR, respectively. Read More

    National Trends and Predictors of Locally Advanced Penile Cancer in the United States (1998-2012).
    Clin Genitourin Cancer 2017 Aug 12. Epub 2017 Aug 12.
    Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL.
    Background: We analyzed the trends in presentation of squamous cell carcinoma (SCC) of the penis and determined the socioeconomic predictors for locally advanced (cT3-cT4) disease in the United States.

    Patient And Methods: The National Cancer Database was queried for patients with clinically nonmetastatic penile SCC and staging available from 1998 to 2012. Temporal trends per tumor stage were evaluated, and a multivariable logistic regression model was used to identify predictors for advanced presentation during the study period. Read More

    HPV-related squamous cell carcinoma in a neovagina after male-to-female gender confirmation surgery.
    Int J STD AIDS 2017 Jan 1:956462417728856. Epub 2017 Jan 1.
    1 General and Digestive Surgery Unit, 16689 Hospital de la Santa Creu i Sant Pau , Carrer Sant Antoni Maria Claret, Universidad Autónoma de Barcelona, Barcelona, Spain.
    Vaginoplasty by penile and scrotal skin inversion is a well-established technique for male-to-female gender confirmation surgery. In this setting, chronic inflammation and lacerations associated with history of human papillomavirus (HPV) infection may induce a high risk of malignant degeneration in the long term. A 78-year-old transgender woman was admitted with genital discomfort and neovaginal discharge. Read More

    Glansectomy as Primary Management of Penile Squamous Cell Carcinoma: An International Study Collaboration.
    Urology 2017 Nov 14;109:140-144. Epub 2017 Aug 14.
    Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL.
    Objective: To analyze the recurrence and survival outcomes of glansectomy in patients with penile squamous cell carcinoma.

    Materials And Methods: We performed a retrospective review of 410 patients across 5 international tertiary referral centers between 1999 and 2016. All patients had tumors involving the glans penis and underwent glansectomy as primary treatment. Read More

    Advances in Understanding of Penile Carcinogenesis: The Search for Actionable Targets.
    Int J Mol Sci 2017 Aug 16;18(8). Epub 2017 Aug 16.
    Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA.
    Penile cancer (PeCa) is a rare malignancy with potentially devastating effects. Squamous cell carcinoma is the most common variant with distinct precancerous lesions before development into invasive disease. Involvement of the inguinal lymph nodes is the most important prognostic factor in PeCa, and once disease is present outside the groin, prognosis is poor. Read More

    Squamous Cell Carcinoma of the Penis with Pulmonary Metastasis and Paraneoplastic Hypertrophic Osteopathy in a Dog.
    J Am Anim Hosp Assoc 2017 Sep/Oct;53(5):277-280. Epub 2017 Aug 9.
    From the University of Florida, Gainesville, Florida (V.J., C.H.d.M.S.); Hôpital Vétérinaire Rive-Sud, Brossard, Quebec, Canada (L-P.d.L.); IPEV, Rio de Janeiro, Brazil (E.d.T-P.).
    Squamous cell carcinoma of the penis was diagnosed by incisional biopsy of a penile mass in a 12 yr old intact male beagle dog presenting with hemorrhagic discharge from the prepuce. Penile amputation, orchiectomy with scrotal ablation, and scrotal urethrostomy were performed. Hypertrophic osteopathy secondary to pulmonary metastatic disease occurred 10 mo after the surgery. Read More

    E2F1 Signalling is Predictive of Chemoresistance and Lymphogenic Metastasis in Penile Cancer: A Pilot Functional Study Reveals New Prognostic Biomarkers.
    Eur Urol Focus 2017 Mar 1. Epub 2017 Mar 1.
    Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Centre, Rostock, Germany. Electronic address:
    Background: For penile cancer (PC) there are no known molecular predictors of lymphatic spread and/or chemoresistance.

    Objective: To identify functional biomarkers that can predict malignant progression and treatment responsiveness.

    Design, Setting, And Participants: We used four patient-derived PC cell lines and measured invasion and capillary tube formation, chemoresponsiveness, and mRNA and protein expression. Read More

    Gene Expression Profiling of Advanced Penile Squamous Cell Carcinoma Receiving Cisplatin-based Chemotherapy Improves Prognostication and Identifies Potential Therapeutic Targets.
    Eur Urol Focus 2016 Aug 27. Epub 2016 Aug 27.
    Department of Medicine, Section of Oncology, UAB School of Medicine, Birmingham, AL, USA. Electronic address:
    In men with advanced penile squamous cell carcinoma receiving first-line chemotherapy, visceral metastases (VM) and Eastern Cooperative Oncology Group performance status ≥1 are poor prognostic factors for overall survival (OS). We hypothesized that tumor gene expression profiling may enhance prognostic stratification and identify potential therapeutic targets. In this retrospective study, RNA extracted from macrodissected tumors underwent profiling for the expression of 738 genes using NanoString. Read More

    The diagnosis and management of male genital lichen sclerosus: a retrospective review of 301 patients.
    J Eur Acad Dermatol Venereol 2017 Jul 27. Epub 2017 Jul 27.
    Department of Dermatology, University College London Hospitals, London, UK.
    Introduction: Male genital lichen sclerosus (MGLSc) is an acquired, chronic, inflammatory skin disease that is associated with significant morbidity and squamous cell carcinoma of the penis (PSCC). However, some clinical, diagnostic and management controversies endure, including the relationship with penile intraepithelial neoplasia (PeIN).

    Objectives: To clarify clinical presentations, diagnostic approaches, histological findings, response to treatment and the relationship with PeIN. Read More

    Novel Additions to the AJCC's New Staging Systems for Skin Cancer.
    Actas Dermosifiliogr 2017 Nov 18;108(9):818-826. Epub 2017 Jul 18.
    Servicio de Dermatología, Complejo Asistencial Universitario de Salamanca, Salamanca, España; IBSAL Instituto de Investigación Biomédica de Salamanca, Complejo Asistencial Universitario de Salamanca, Salamanca, España.
    The eighth edition of the staging manual of the American Joint Committee on Cancer incorporates important changes in the classification of skin cancers. Coming 40 years after the first edition, the latest manual preserves its specific system for Merkel cell carcinoma and takes into account recent publications on the prognosis of squamous cell carcinoma by defining a completely new T category for this neoplasm. Staging for squamous cell carcinoma considers head and neck tumors (excluding the eyelid) and does not offer solutions for other sites except the vulva, penis, and perianal region. Read More

    Neuroendocrine factors: The missing link in non‑melanoma skin cancer (Review).
    Oncol Rep 2017 Sep 13;38(3):1327-1340. Epub 2017 Jul 13.
    Laboratory of Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece.
    Non‑melanoma skin cancer (NMSC) is the most common form of cancer worldwide, comprising 95% of all cutaneous malignancies and approximately 40% of all cancers. In spite of intensive efforts aimed towards awareness campaigns and sun‑protective measures, epidemiological data indicate an increase in the incidence of NMSC. This category of skin cancers has many common environmental triggers. Read More

    Sarcomatoid Squamous Cell Carcinoma of the Penis - a Report of Two Cases.
    Folia Med (Plovdiv) 2017 Jun;59(2):232-237
    .
    Background: Sarcomatoid (spindle cell) squamous cell carcinoma is a rare, highgrade, aggressive tumor consisting of the squamous cell carcinoma admixed with the malignant spindle cell (sarcomatoid) elements. These tumors are relatively uncommon in the genitourinary system and particularly in the penis.

    Materials And Methods: Two sarcomatoid squamous cell carcinomas of the penis were diagnosed in our hospital between 2012 and 2015. Read More

    Exophytic papillary penile cancer.
    Prog Urol 2017 Sep 4;27(10):564-566. Epub 2017 Jul 4.
    Department of pathology, hospital Juárez de México, Mexico City, Mexico.
    Penile carcinoma is a rare disease that has a wide range of pathology and morbidity. Occurs commonly in the 6th and 7th decades of life. Squamous cell carcinoma (SCC) is the predominant histological type. Read More

    Urologic Dermatology: a Review.
    Curr Urol Rep 2017 Aug;18(8):62
    Virginia Mason Medical Center, Seattle, WA, USA.
    Purpose Of Review: Genital dermatology represents a challenge to many providers. Though dermatologic lesions involving the genitalia may present to any of a number of practices, ranging from primary care to urology, gynecology, and dermatology, few training programs provide significant training regarding the diagnosis and management of genital dermatologic lesions. The purpose of this review is to provide urologists with an overview of common genital dermatological lesions that may be encountered in a clinic. Read More

    Adjuvant pelvic radiation is associated with improved survival and decreased disease recurrence in pelvic node-positive penile cancer after lymph node dissection: A multi-institutional study.
    Urol Oncol 2017 Oct 27;35(10):605.e17-605.e23. Epub 2017 Jun 27.
    Department of Urology, Moffitt Cancer Center, Tampa, FL.
    Purpose: Few studies have examined the role of radiation therapy in advanced penile squamous cell carcinoma. We sought to evaluate the association of adjuvant pelvic radiation with survival and recurrence for patients with penile cancer and positive pelvic lymph nodes (PLNs) after lymph node dissection.

    Materials And Methods: Data were collected retrospectively across 4 international centers of patients with penile squamous cell carcinoma undergoing lymph node dissections from 1980 to 2013. Read More

    Human Papillomavirus (HPV) Genotypes in Condylomas, Intraepithelial Neoplasia, and Invasive Carcinoma of the Penis Using Laser Capture Microdissection (LCM)-PCR: A Study of 191 Lesions in 43 Patients.
    Am J Surg Pathol 2017 Jun 13. Epub 2017 Jun 13.
    *Polytechnic School §School of Medicine, National University of Asunción †Instituto de Patología e Investigación, Asunción, Paraguay ‡DDL Diagnostic Laboratory, Rijswijk, The Netherlands ∥Miraca Life Sciences and Tufts University, Boston, MA.
    Laser capture microdissection-polymerase chain reaction (LCM-PCR) supported by p16 was used for the first time to demonstrate human papillomavirus (HPV) DNA in histologically specific penile lesions, which were as follows: squamous hyperplasia (12 lesions, 10 patients), flat lesions (12 lesions, 5 patients), condylomas (26 lesions, 7 patients), penile intraepithelial neoplasia (PeIN) (115 lesions, 43 patients), and invasive squamous cell carcinomas (26 lesions, 26 patients). HPV was detected by whole-tissue section and LCM-PCR. LCM proved to be more precise than whole-tissue section in assigning individual genotypes to specific lesions. Read More

    Experimental validation of the complement protein C3a down expression in the plasma of patients with squamous cell carcinoma of the penis.
    Urol Oncol 2017 Sep 25;35(9):545.e13-545.e18. Epub 2017 May 25.
    Programa de Pós-Graduação em Ciências Médicas, Circulating Biomarkers Laboratory, Department of Pathology, Rio de Janeiro State University, Rio de Janeiro, Brazil; Research Coordination, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.
    Objectives: We have previously shown the importance of the complement system in differentiating between patients with squamous cell carcinoma of the penis (SCCP) and controls. These patients had low expression of C3a and C4 fragments. Therefore, in this study, we investigated the complement protein C3a as a potential circulating biomarker in these patients by a commercially available enzyme-linked immunosorbent assay (ELISA) test. Read More

    A exceptional collision tumor of primary adrenal angiosarcoma and non-functioning adrenocortical adenoma.
    Pathol Res Pract 2017 Jun 19;213(6):702-705. Epub 2017 Apr 19.
    Department of Anatomic pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan. Electronic address:
    Primary adrenal angiosarcoma is an extremely rare vascular tumor. We report a case of a 63-year-old man with a collision tumor of epithelioid angiosarcoma and adrenocortical adenoma of the right adrenal gland. The adrenal tumor was incidentally observed by a preoperative computed tomography (CT) scan of penis squamous cell carcinoma. Read More

    Brachytherapy for Conservative Treatment of Invasive Penile Carcinoma: Prognostic Factors and Long-Term Analysis of Outcome.
    Int J Radiat Oncol Biol Phys 2017 Feb 28. Epub 2017 Feb 28.
    Brachytherapy Unit, Gustave Roussy, Villejuif, France; Radiotherapy Department, Gustave Roussy, Villejuif, France; Institut de Recherche Biomédicale des Armées, Bretigny-sur-Orge, France; French Military Health Academy, Ecole du Val-de-Grâce, Paris, France. Electronic address:
    Purpose: To report the largest experience with brachytherapy as a conservative approach for the treatment of penile carcinoma.

    Methods And Materials: We examined the outcomes of 201 patients treated at our institution over 45 years for invasive squamous cell carcinoma of the glans penis by brachytherapy.

    Results: With a median follow-up of 10. Read More

    Human Papillomavirus (HPV) Genotypes in Condylomas, Intraepithelial Neoplasia, and Invasive Carcinoma of the Penis Using Laser Capture Microdissection (LCM)-PCR: A Study of 191 Lesions in 43 Patients.
    Am J Surg Pathol 2017 Jun;41(6):820-832
    *Polytechnic School §School of Medicine, National University of Asunción †Instituto de Patología e Investigación, Asunción, Paraguay ‡DDL Diagnostic Laboratory, Rijswijk, The Netherlands ∥Miraca Life Sciences and Tufts University, Boston, MA.
    Laser capture microdissection-polymerase chain reaction (LCM-PCR) supported by p16 was used for the first time to demonstrate human papillomavirus (HPV) DNA in histologically specific penile lesions, which were as follows: squamous hyperplasia (12 lesions, 10 patients), flat lesions (12 lesions, 5 patients), condylomas (26 lesions, 7 patients), penile intraepithelial neoplasia (PeIN) (115 lesions, 43 patients), and invasive squamous cell carcinomas (26 lesions, 26 patients). HPV was detected by whole-tissue section and LCM-PCR. LCM proved to be more precise than whole-tissue section in assigning individual genotypes to specific lesions. Read More

    Clinicopathologic Characteristics and Treatment Outcomes of Penile Cancer.
    World J Mens Health 2017 Apr;35(1):28-33
    Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.
    Purpose: The aim of this study was to assess the clinicopathologic characteristics of penile cancer, including patterns of therapy, oncologic results, and survival.

    Materials And Methods: Between January 2005 and July 2015, 71 patients at 6 institutions who had undergone penectomy or penile biopsy were enrolled. Their medical records were reviewed to identify the mode of therapy, pathology reports, and cancer-specific survival (CSS) rate. Read More

    Co-infection of syphilis and hepatitis B with carcinoma penis in a human immunodeficiency virus male.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):78-80
    Department of STD, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India.
    Human immunodeficiency virus (HIV) infections have a high probability of co-infections with Syphilis and hepatitis B virus since they share the common routes of transmission. We report a 41-year-old HIV male (on antiretroviral therapy for the past 6 years) admitted for a complaint of penile ulcer for 2 months. Serology for syphilis and hepatitis B were positive. Read More

    Kinase analysis of penile squamous cell carcinoma on multiple platforms to identify potential therapeutic targets.
    Oncotarget 2017 Mar;8(13):21710-21718
    Department of Medicine, Section of Oncology, UAB School of Medicine, Birmingham, Alabama, USA.
    Penile squamous cell carcinoma (PSCC) is an orphan malignancy with poorly understood biology and suboptimal systemic therapy. Given that kinases may be drivers and readily actionable, we performed comprehensive multiplatform analysis of kinases in PSCC tumor and normal tissue. Fresh frozen tumors were collected from 11 patients with PSCC. Read More

    Pseudoepitheliomatous keratotic and micaceous balanitis treated with topical 5-fluorouracil and liquid nitrogen.
    Clin Exp Dermatol 2017 Apr 13. Epub 2017 Apr 13.
    Dermatology Department, National Skin Centre, Singapore.
    Pseudoepitheliomatous keratotic and micaceous balanitis (PKMB) is an uncommon premalignant condition involving the glans penis. We report the case of an 86-year-old man who presented with phimosis and pain on retracting his foreskin. He had previously undergone circumcision, which revealed a hyperkeratotic plaque with thin mica-like scales involving his glans penis. Read More

    HPV-negative penile squamous cell carcinoma: disruptive mutations in the TP53 gene are common.
    Mod Pathol 2017 Jul 7;30(7):1013-1020. Epub 2017 Apr 7.
    Institute of Pathology, Medical University of Graz, Graz, Austria.
    The majority of penile squamous cell carcinomas is caused by transforming human papilloma virus (HPV) infection. The etiology of HPV-negative cancers is unclear, but TP53 mutations have been implicated. Archival tissues of 108 invasive squamous cell carcinoma from a single pathology institution in a low-incidence area were analyzed for HPV-DNA and p16(ink4a) overexpression and for TP53 mutations by ion torrent next-generation sequencing. Read More

    Human papillomavirus 16 is an aetiological factor of scrotal cancer.
    Br J Cancer 2017 Apr 4;116(9):1218-1222. Epub 2017 Apr 4.
    Research and Development, DDL Diagnostic Laboratory, Rijswijk, The Netherlands.
    Background: Squamous cell scrotal carcinoma (SCSC) is an infrequent skin cancer associated historically with occupational carcinogens. Human papillomavirus (HPV) DNA has been associated with SCSC but there is no definitive proof of its oncogenic role.

    Methods: Human papillomavirus-DNA and -E6*I mRNA were analysed in six invasive histologically typed SCSC. Read More

    Disparity between pre-existing management of penile cancer and NCCN guidelines.
    Urol Oncol 2017 Aug 28;35(8):531.e9-531.e14. Epub 2017 Mar 28.
    Department of Urology, UH Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, OH; Division of Urology, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH. Electronic address:
    Objective: To determine the locoregional management of penile cancer before the introduction of NCCN guidelines and how much shift in practice patterns is required to meet the guidelines.

    Methods: The National Cancer Data Base was queried to identify 6,396 patients with squamous cell carcinoma of the penis diagnosed between 2004 and 2013. The cohort was divided into management groups based on the NCCN guidelines: cTa and cTis (cTa/is), pT1 low grade (T1LG), pT1 high grade (T1HG), and pT2 or greater (T234). Read More

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