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    Validation of predictors for lymph node status in penile cancer: Results from a population-based cohort.
    Can Urol Assoc J 2017 Dec 22. Epub 2017 Dec 22.
    Department of Oncology, Queen's University, Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston, ON; Canada.
    Introduction: The ability to predict lymph node (LN) status is essential in the management of men with localized squamous cell carcinoma (SCC) of the penis. There has been limited external validation of available risk stratification tools, particularly in routine clinical care. The objective of this study was to evaluate the predictive variables of LN metastases within a large population-based cohort of patients. Read More

    Histological subtype is a significant predictor for inguinal lymph node metastasis in patients with penile squamous cell carcinoma.
    Asian J Androl 2017 Dec 29. Epub 2017 Dec 29.
    Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.
    The present study aimed to investigate the relationship between histopathological subtype and the probability of inguinal lymph node metastasis (ILNM) in patients with penile squamous cell carcinoma (PSCC). The clinical records of 198 consecutive patients with PSCC were analyzed retrospectively. Primary lesions were reevaluated according to the 2016 World Health Organization (WHO) histopathological classification. Read More

    Racial disparity and survival outcomes between African American and Caucasian men with penile cancer.
    BJU Int 2017 Dec 27. Epub 2017 Dec 27.
    Department of Urology, University of Miami Leonard M. Miller School of Medicine, Miami, FL.
    Objective: To determine whether there was a survival difference for AAM versus CM with penile squamous cell carcinoma (pSCC), particularly in locally advanced and metastatic cases where disease mortality is highest.

    Methods: Using the Florida Cancer Data System, we identified men with pSCC from 2005 to 2013. We compared age, follow-up, stage, race, and treatment type between AAM and CM. Read More

    Differences in Survival by Receipt of Lymph Node Dissection in Patients with Invasive Penile cancer: Results from the National Cancer Database.
    J Urol 2017 Dec 14. Epub 2017 Dec 14.
    Department of Surgical Oncology, Division of Urologic Oncology, Fox Chase Cancer Center, Philadelphia PA.
    Background: Inguinal lymphadenectomy (I-LND) remains underutilized in patients with invasive penile cancer. Using a large national cancer registry, we assessed temporal trends in I-LND utilization and evaluated the impact of I-LND on the survival in patients in whom I-LND is an absolute indication per NCCN guidelines (T1b-4 N0/x-1).

    Methods: The National Cancer Database (NCDB) was queried for all non-metastatic penile patients with T1b-4 N0/X-N1 squamous cell carcinoma of the penis from 2004-2014. Read More

    Trends in incidence, mortality and survival of penile squamous cell carcinoma in Norway 1956-2015.
    Int J Cancer 2017 Dec 4. Epub 2017 Dec 4.
    Department of Research, Cancer Registry of Norway, Oslo, Norway.
    We examine trends in incidence, mortality and survival of penile squamous cell carcinoma (SCC) in Norway over 60 years. Data on all cases of penile cancer diagnosed in Norway during 1956-2015 were obtained from the Cancer Registry of Norway. Trends in age-standardized rates of penile SCC incidence, mortality and 5-year relative survival were assessed by the annual percentage change statistic and joinpoint regression. Read More

    Thulium-yttrium-aluminium-garnet (Tm:YAG) laser treatment of penile cancer: oncological results, functional outcomes, and quality of life.
    World J Urol 2017 Dec 2. Epub 2017 Dec 2.
    Department of Urology, Istituto Europeo di Oncologia, Via Ripamonti 435, Milan, Italy.
    Purpose: To evaluate the oncological and functional outcomes of patients diagnosed with penile cancer undergoing conservative treatment through thulium-yttrium-aluminium-garnet (Tm:YAG) laser ablation.

    Methods: Twenty-six patients with a penile lesion underwent ablation with a RevoLix 200 W continuous-wave laser. The procedure was carried out with a pen-like laser hand piece, using a 360 μm laser fiber and 15-20 W of power. Read More

    Contemporary role of radiotherapy in the management of penile cancer.
    Transl Androl Urol 2017 Oct;6(5):855-867
    British Columbia Cancer Agency, Center for the Southern Interior, Kelowna, BC, Canada.
    Penile cancer is a rare clinical entity that contributes to significant patient morbidity and mortality. Human papilloma virus (HPV) plays an important role in the carcinogenesis of penile squamous cell carcinoma (SCC), is associated with improved clinical outcomes, and is predictive for response to treatment with chemotherapy and radiotherapy. Historically, treatment consisted of radical surgery with partial or total penectomy. Read More

    Beyond chemotherapy for advanced disease-the role of EGFR and PD-1 inhibitors.
    Transl Androl Urol 2017 Oct;6(5):848-854
    Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
    Penile squamous cell carcinoma (SCC) is a rare malignancy with limited treatment options when the tumor is unresectable and/or chemorefractory. Triplet systemic chemotherapy regimens including taxane and cisplatin are recommended, but the response duration can be short and the treatment-related toxicity high. Only a small proportion of patients survive 1 year or longer with the current standard treatment paradigm. Read More

    Robotic inguinal lymphadenectomy for penile cancer: the why, how, and what.
    Transl Androl Urol 2017 Oct;6(5):826-832
    Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL, USA.
    Squamous cell carcinoma of the penis (SCC-P) demonstrates a reliable pattern of spread to the lymph nodes of the groin. High grade and higher stage (pT1b or greater) SCC-P demonstrate a higher propensity for metastasis to the inguinal lymph nodes. Further, lymphadenopathy progresses in a predictable fashion, from superficial inguinal lymph nodes to deep inguinal lymph nodes to pelvic lymph nodes, with limited survival noted for those patients with progression to pelvic lymph nodes. Read More

    Topical Therapy for non-invasive penile cancer (Tis)-updated results and toxicity.
    Transl Androl Urol 2017 Oct;6(5):803-808
    Department of Urology, St George's Hospital, London, UK.
    Penile cancer is a rare malignancy estimated to affect 26,000 men globally each year. The association with penile cancer, in particular non-invasive disease, and human papilloma virus (HPV) is well known. Ninety-five percent of cases of penile cancer are squamous cell carcinoma (SCC), which are staged using the TNM staging system. Read More

    Prevalence of oncogenic human papillomavirus genotypes in patients diagnosed with anogenital malignancies in Botswana.
    BMC Infect Dis 2017 Nov 25;17(1):731. Epub 2017 Nov 25.
    Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Botswana, Private Bag UB072, 4775 Notwane Rd., Gaborone, Botswana.
    Background: Human papillomavirus (HPV) associated malignancies are the leading cause of cancer death in Botswana. We sought to determine causative HPV types in patients with anogenital malignancies in Botswana to inform vaccine strategy.

    Methods: We used formalin-fixed and paraffin-embedded (FFPE) tissue blocks from patients diagnosed with anal, penile and vulvar squamous cell carcinomas between the years, 2014 and 2016. Read More

    APOBEC3A Expression in Penile Squamous Cell Carcinoma.
    Pathobiology 2017 Nov 23. Epub 2017 Nov 23.
    Section of Molecular Urooncology, Department of Urology, Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, Germany.
    Background: APOBECs (apolipoprotein B mRNA-editing catalytic polypeptides) are cytidine deaminases that have been implicated in the host defense against viruses by blocking viral replication. They have also been shown to play a role in genome hypermutation in several human cancers. An APOBEC3 hypermutation signature has been discovered in cervical cancer, which is intimately associated with infection by high-risk human papillomaviruses (HPVs). Read More

    Video Endoscopic Inguinal Lymphadenectomy vs Open Inguinal Lymphadenectomy for Carcinoma Penis: Expanding Role and Comparison of Outcomes.
    Urology 2017 Nov 16. Epub 2017 Nov 16.
    Department of Urology and Renal Transplantation, SMS Medical College, Jaipur, Rajasthan, India.
    Objective: To compare differences of morbidity profile, oncological yield, and efficacy between video endoscopic inguinal lymphadenectomy and open inguinal lymphadenectomy cases.

    Materials And Methods: A total of 29 patients with proven squamous cell carcinoma of the penis were selected for inguinal lymphadenectomy from August 2013 to January 2017. Video endoscopic lymphadenectomy was performed on 1 limb and open inguinal lymphadenectomy was performed on the contralateral side. Read More

    Penile warty mucoepidermoid carcinoma with features of stratified mucin-producing intra-epithelial lesion and invasive stratified mucin-producing carcinoma.
    Histopathology 2017 Nov 16. Epub 2017 Nov 16.
    Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Pilsen, Czech Republic.
    Aims: Stratified mucin-producing intra-epithelial lesion (SMILE) and invasive stratified mucin-producing carcinoma (ISMC) are recently described cervical and penile lesions. We report an unusual case of mixed variant of penile squamous cell carcinomas with warty, usual and mucoepidermoid SMILE/ISMC features.

    Methods And Results: A 62-year-old Japanese man had a glans penis lesion of one-and-a-half years' duration, suggesting malignancy. Read More

    Successful downstaging of locally recurrent penile squamous cell carcinoma with neoadjuvant nanosomal docetaxel lipid suspension (NDLS) based regimen followed by curative surgery.
    BMJ Case Rep 2017 Nov 12;2017. Epub 2017 Nov 12.
    Department of Medical Affairs and Clinical Research, Intas Pharmaceuticals Limited, Ahmedabad, India.
    Penile squamous cell carcinoma (pSCC) is a relatively rare disease in Western world but is a significant health problem in developing countries like India. We report here a case of successful multimodality management of recurrent pSCC with pelvic lymphadenopathy in a 56-year-old male patient with poorly controlled diabetes. The patient presented with ulceroproliferative growth over the residual penile stump clinically involving root of penis and with right pelvic lymphadenopathy. Read More

    CD109 expression is upregulated in penile squamous cell carcinoma.
    Oncol Lett 2017 Nov 15;14(5):6012-6016. Epub 2017 Sep 15.
    Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.
    Cluster of differentiation (CD) 109 is a glycosylphosphatidylinositol-anchored cell surface glycoprotein and a co-receptor for transforming growth factor β. The expression of CD109 has been detected in squamous cell carcinoma of the lung, esophagus, skin and gallbladder. The aim of the present study was to evaluate CD109 expression in penile squamous cell carcinoma (PSCC). Read More

    Impact of County Rurality and Urologist Density on the Practice of Inguinal Lymph Node Dissection and Mortality in Patients Diagnosed with Squamous Cell Carcinoma of the Penis.
    Ann Surg Oncol 2018 Jan 6;25(1):334-341. Epub 2017 Nov 6.
    Urologic Oncology, Department of Urology, Henry Ford Health System, Detroit, MI, USA.
    Background: Inguinal lymphadenectomy (LND) is influential in reducing the mortality of squamous cell carcinoma of the penis (SCCP). We investigated the impact of urologic workforce density (UD) and rural residence (RR) on the practice of LND and mortality of SCCP (SCCP-RM).

    Materials And Methods: UD was determined from the 2014 to 2015 Area Health Resource File data, while RR was determined using the 2003 rural-urban continuum codes. Read More

    Five-year relative survival for human papillomavirus-associated cancer sites.
    Cancer Cytopathol 2018 Jan 6;124(1):203-211. Epub 2017 Nov 6.
    National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.
    Background: Human papillomavirus (HPV) vaccines can potentially prevent greater than 90% of cervical and anal cancers as well as a substantial proportion of vulvar, vaginal, penile, and oropharyngeal cancers caused by certain HPV types. Because more than 38,000 HPV-associated cancers are diagnosed annually in the United States, current studies are needed to understand how relative survival varies for each of these cancers by certain demographic characteristics, such as race and age.

    Methods: The authors examined high-quality data from 27 population-based cancer registries covering approximately 59% of the US population. Read More

    The World Health Organization 2016 classification of penile carcinomas: a review and update from the International Society of Urological Pathology expert driven recommendations.
    Histopathology 2017 Nov 3. Epub 2017 Nov 3.
    Department of Cellular Pathology, St George's Healthcare NHS Foundation Trust, London, UK.
    The International Society of Urological Pathology (ISUP) held an expert driven penile cancer conference in Boston in March 2015 which focused on the new WHO classification of penile cancer: HPV-related tumors and histological grading. The conference was preceded by an online survey of the International Society of Urological Pathology members and the results were used to initiate discussions. Because of the rarity of penile tumors, this was not a consensus but an expert driven conference aiming to assist pathologists who do not see these tumor on a regular basis. Read More

    Insight into novel biomarkers in penile cancer: Redefining the present and future treatment paradigm?
    Urol Oncol 2017 Nov 2. Epub 2017 Nov 2.
    Departments of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL. Electronic address:
    Introduction: Biomarkers are increasingly used in the diagnosis and management of various malignancies. Selected biomarkers may also play a role in management of certain cases of penile carcinoma. In this article, we provide an overview of the clinical role of such markers in the management of penile cancer. Read More

    Laser ablation as monotherapy for penile squamous cell carcinoma: A multi-center cohort analysis.
    Urol Oncol 2017 Oct 30. Epub 2017 Oct 30.
    Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL.
    Introduction: Although the trend towards penile sparing therapy is increasing for penile squamous cell carcinoma, outcomes for laser ablation therapy have not been widely reported. We assessed the clinical outcomes of penile cancer patients treated with only laser ablation.

    Materials And Methods: A retrospective review was performed on 161 patients across 5 multi-center tertiary referral centers from 1985 to 2015. Read More

    Benefits of Urologic-Dermatologic Consultations for the Diagnosis of Cutaneous Penile Lesions: A Prospective Study.
    Clin Genitourin Cancer 2017 Oct 5. Epub 2017 Oct 5.
    Department of Urology, Angers University Hospital, Angers, France.
    Introduction: We evaluated the benefits of a specialized consultation created in 2014 for cutaneous penile lesions.

    Materials And Methods: We performed a descriptive prospective study evaluating all patients sent for a monthly urologic-dermatologic consultation at a French university hospital from September 2014 to September 2015 for cutaneous penile lesions. All patients evaluated were included. Read More

    Management of penile cancer in a Singapore tertiary hospital.
    Arab J Urol 2017 Jun 30;15(2):123-130. Epub 2017 Mar 30.
    Tan Tock Seng Hospital, Singapore, Singapore.
    Objectives: To present our experience of managing penile squamous cell carcinoma (SCC) in a tertiary hospital in Singapore and to evaluate the prognostic value of the inflammatory markers neutrophil-lymphocyte ratio (NLR) and lymphocyte-monocyte ratio (LMR).

    Patients And Methods: We reviewed our prospectively maintained Institutional Review Board-approved urological cancer database to identify men treated for penile SCC at our centre between January 2007 and December 2015. For all the patients identified, we collected epidemiological and clinical data. Read More

    Saphenous-sparing laparoscopic inguinal lymphadenectomy.
    Int Braz J Urol 2017 Oct 24;43. Epub 2017 Oct 24.
    San Bassiano Hospital - Urology, Bassano del Grappa, Italy.
    Introduction: Inguinal lymphadenectomy is an integral part in the management of penile cancer. Video endoscopic in-guinal lymphadenectomy (VEIL) is emerging as a minimally invasive treatment to reduce postoperative complications.

    Materials And Methods: 62 years old man underwent glansectomy for a squamous cell carcinoma (pT1b). Read More

    Oral Human Papillomavirus Infection: Differences in Prevalence Between Sexes and Concordance With Genital Human Papillomavirus Infection, NHANES 2011 to 2014.
    Ann Intern Med 2017 Nov 17;167(10):714-724. Epub 2017 Oct 17.
    From University of Florida, Gainesville, Florida; Baylor College of Medicine and The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas; Harvard Medical School, Boston, Massachusetts; and Weill Cornell Medicine, New York, New York.
    Background: The burden of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is disproportionately high among men, yet empirical evidence regarding the difference in prevalence of oral HPV infection between men and women is limited. Concordance of oral and genital HPV infection among men is unknown.

    Objective: To determine the prevalence of oral HPV infection, as well as the concordance of oral and genital HPV infection, among U. Read More

    Cancer incidence in Germany attributable to human papillomavirus in 2013.
    BMC Cancer 2017 Oct 16;17(1):682. Epub 2017 Oct 16.
    Department of Epidemiology and Health Monitoring, Robert Koch-Institut, Berlin, Germany.
    Background: It is estimated that a total of 120,000 new cancer cases in men and in women in more developed countries could be avoided if exposure to HPV was prevented. We used the nationwide pool of German population-based cancer registry data to estimate the burden of HPV-attributable cancer in this population for the year 2013.

    Methods: Incident cases of cervical cancer, squamous cell carcinoma of the anus, oropharynx (OP), as well as of the vulva, vagina and penis were classified as potentially HPV-associated and identified from the nationwide cancer registry data-pool. Read More

    Evaluating the accuracy of intraoperative frozen section during inguinal lymph node dissection in penile cancer.
    Urol Oncol 2018 Jan 9;36(1):14.e1-14.e5. Epub 2017 Oct 9.
    Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL.
    Introduction: Inguinal lymph node dissection is an integral part in the management of invasive penile tumors with intraoperative assessment often aiding decision-making during dissection. In this study, we evaluate the diagnostic value of intraoperative frozen section (FS) and analyze clinicopathologic factors that affect its accuracy.

    Material And Methods: We, retrospectively, reviewed 84 patients with squamous cell carcinoma of the penis who underwent inguinal lymph node dissection at our institution. Read More

    [Urethral ectropion may hide a carcinoma!]
    Pan Afr Med J 2017 3;27:249. Epub 2017 Aug 3.
    Université Mohammed V, Faculté de Médecine et de Pharmacie de Rabat, Hopital Ibn Sina, Service d'Urologie B, Rabat, Maroc.
    The incidence of female urethral cancer is rare and accounts for 0.02% of all women's cancers. It is dominated by epidermoid carcinoma, which most commonly develops in the distal portion of the urethra, extending to inguinal lymph nodes. Read More

    Novel Histologic Finding: Adipose Tissue Is Prevalent Within Penile Tunica Albuginea and Corpora Cavernosa: An Anatomic Study of 63 Specimens and Considerations for Cancer Invasion.
    Am J Surg Pathol 2017 Nov;41(11):1542-1546
    *Pathology and Research Institute †School of Medicine, National University of Asunción, Asunción, Paraguay.
    Adipose tissue, along with arteries, veins, and peripheral nerves, is a normal constituent of mesenchymal tissues encasing the corpora cavernosa at the level of the penile shaft, variously designated as penile fascia or Bucks fascia. To our knowledge, the presence of fat has not been previously reported within the corpora cavernosa. One or 2 transversal histologic sections at the level of the surgical margin at the shaft of 63 consecutive partial penectomy specimens for squamous cell carcinoma were evaluated. Read More

    First-line therapy with dacomitinib, an orally available pan-HER tyrosine kinase inhibitor, for locally advanced or metastatic penile squamous cell carcinoma: results of an open-label, single-arm, single-centre, phase 2 study.
    BJU Int 2017 Sep 16. Epub 2017 Sep 16.
    Urology Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
    Objective: To harness the frontline therapy in advanced penile squamous cell carcinoma (PSCC), for which chemotherapy exerts moderate activity but poor efficacy. Dacomitinib is an irreversible, pan-epidermal growth factor receptor (HER) inhibitor.

    Patients And Methods: In a phase 2 study (NCT01728233), patients received dacomitinib 45 mg/day, orally, continuously. Read More

    Squamous Cell Carcinoma Penis in a Case of Urethral Stricture Due to Lichen Sclerosus Balanitis Xerotica Obliterans: A Case Report and Review of Literature.
    J Clin Diagn Res 2017 Jul 1;11(7):PD17-PD18. Epub 2017 Jul 1.
    Head, Department of Urology, Sri Sathya Sai Institute of Higher Medical Sciences, Prashantigram, Ananthpur, Andhra Pradesh, India.
    Penile carcinoma is considered a delayed sequel of lichen sclerosus. It is important to recognize this not so uncommon complication in time as survival of patients with Squamous Cell Carcinoma (SCC) depends on early diagnosis and treatment. We describe a case of a 49-year-old male presenting with urethral stricture due to lichen sclerosus. Read More

    Predictive factors for local recurrence after glansectomy and neoglans reconstruction for penile squamous cell carcinoma.
    Urol Oncol 2017 Sep 4. Epub 2017 Sep 4.
    Department of Urology, University College London Hospital, London, UK; NIHR Biomedical Research Centre at University College London Hospitals, London, UK. Electronic address:
    Objectives: To investigate predictive pathological factors for local recurrence (LR) after glansectomy for penile squamous cell carcinoma (SCC) and to develop a risk score for prediction of LR after glansectomy.

    Patients And Methods: In this retrospective study, we analyzed 117 patients operated between February 2005 and January 2016 in a supraregional penile cancer center in the UK for LR after glansectomy and glans reconstruction. Univariate and multivariate Cox proportional hazards regression was used to identify 4 prognostic indicators for LR. Read More

    More precise prediction in Chinese patients with penile squamous cell carcinoma: protein kinase CK2α catalytic subunit (CK2α) as a poor prognosticator.
    Oncotarget 2017 Aug 16;8(31):51542-51550. Epub 2017 May 16.
    Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.
    Purpose: In this study, we assess the CK2α expression in human penile squamous cell carcinoma (SCC) and its clinical significance.

    Methods: A total of 157 human penile SCC tissue samples were immunohistochemically analyzed. In addition, 12 human penile SCC and adjacent normal tissues were examined for CK2α protein and mRNA expression by Western blotting and real-time quantitative PCR, respectively. Read More

    National Trends and Predictors of Locally Advanced Penile Cancer in the United States (1998-2012).
    Clin Genitourin Cancer 2017 Aug 12. Epub 2017 Aug 12.
    Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL.
    Background: We analyzed the trends in presentation of squamous cell carcinoma (SCC) of the penis and determined the socioeconomic predictors for locally advanced (cT3-cT4) disease in the United States.

    Patient And Methods: The National Cancer Database was queried for patients with clinically nonmetastatic penile SCC and staging available from 1998 to 2012. Temporal trends per tumor stage were evaluated, and a multivariable logistic regression model was used to identify predictors for advanced presentation during the study period. Read More

    HPV-related squamous cell carcinoma in a neovagina after male-to-female gender confirmation surgery.
    Int J STD AIDS 2017 Jan 1:956462417728856. Epub 2017 Jan 1.
    1 General and Digestive Surgery Unit, 16689 Hospital de la Santa Creu i Sant Pau , Carrer Sant Antoni Maria Claret, Universidad Autónoma de Barcelona, Barcelona, Spain.
    Vaginoplasty by penile and scrotal skin inversion is a well-established technique for male-to-female gender confirmation surgery. In this setting, chronic inflammation and lacerations associated with history of human papillomavirus (HPV) infection may induce a high risk of malignant degeneration in the long term. A 78-year-old transgender woman was admitted with genital discomfort and neovaginal discharge. Read More

    Glansectomy as Primary Management of Penile Squamous Cell Carcinoma: An International Study Collaboration.
    Urology 2017 Nov 14;109:140-144. Epub 2017 Aug 14.
    Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL.
    Objective: To analyze the recurrence and survival outcomes of glansectomy in patients with penile squamous cell carcinoma.

    Materials And Methods: We performed a retrospective review of 410 patients across 5 international tertiary referral centers between 1999 and 2016. All patients had tumors involving the glans penis and underwent glansectomy as primary treatment. Read More

    Advances in Understanding of Penile Carcinogenesis: The Search for Actionable Targets.
    Int J Mol Sci 2017 Aug 16;18(8). Epub 2017 Aug 16.
    Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA.
    Penile cancer (PeCa) is a rare malignancy with potentially devastating effects. Squamous cell carcinoma is the most common variant with distinct precancerous lesions before development into invasive disease. Involvement of the inguinal lymph nodes is the most important prognostic factor in PeCa, and once disease is present outside the groin, prognosis is poor. Read More

    Squamous Cell Carcinoma of the Penis with Pulmonary Metastasis and Paraneoplastic Hypertrophic Osteopathy in a Dog.
    J Am Anim Hosp Assoc 2017 Sep/Oct;53(5):277-280. Epub 2017 Aug 9.
    From the University of Florida, Gainesville, Florida (V.J., C.H.d.M.S.); Hôpital Vétérinaire Rive-Sud, Brossard, Quebec, Canada (L-P.d.L.); IPEV, Rio de Janeiro, Brazil (E.d.T-P.).
    Squamous cell carcinoma of the penis was diagnosed by incisional biopsy of a penile mass in a 12 yr old intact male beagle dog presenting with hemorrhagic discharge from the prepuce. Penile amputation, orchiectomy with scrotal ablation, and scrotal urethrostomy were performed. Hypertrophic osteopathy secondary to pulmonary metastatic disease occurred 10 mo after the surgery. Read More

    E2F1 Signalling is Predictive of Chemoresistance and Lymphogenic Metastasis in Penile Cancer: A Pilot Functional Study Reveals New Prognostic Biomarkers.
    Eur Urol Focus 2017 Mar 1. Epub 2017 Mar 1.
    Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Centre, Rostock, Germany. Electronic address:
    Background: For penile cancer (PC) there are no known molecular predictors of lymphatic spread and/or chemoresistance.

    Objective: To identify functional biomarkers that can predict malignant progression and treatment responsiveness.

    Design, Setting, And Participants: We used four patient-derived PC cell lines and measured invasion and capillary tube formation, chemoresponsiveness, and mRNA and protein expression. Read More

    Gene Expression Profiling of Advanced Penile Squamous Cell Carcinoma Receiving Cisplatin-based Chemotherapy Improves Prognostication and Identifies Potential Therapeutic Targets.
    Eur Urol Focus 2016 Aug 27. Epub 2016 Aug 27.
    Department of Medicine, Section of Oncology, UAB School of Medicine, Birmingham, AL, USA. Electronic address:
    In men with advanced penile squamous cell carcinoma receiving first-line chemotherapy, visceral metastases (VM) and Eastern Cooperative Oncology Group performance status ≥1 are poor prognostic factors for overall survival (OS). We hypothesized that tumor gene expression profiling may enhance prognostic stratification and identify potential therapeutic targets. In this retrospective study, RNA extracted from macrodissected tumors underwent profiling for the expression of 738 genes using NanoString. Read More

    The diagnosis and management of male genital lichen sclerosus: a retrospective review of 301 patients.
    J Eur Acad Dermatol Venereol 2017 Jul 27. Epub 2017 Jul 27.
    Department of Dermatology, University College London Hospitals, London, UK.
    Introduction: Male genital lichen sclerosus (MGLSc) is an acquired, chronic, inflammatory skin disease that is associated with significant morbidity and squamous cell carcinoma of the penis (PSCC). However, some clinical, diagnostic and management controversies endure, including the relationship with penile intraepithelial neoplasia (PeIN).

    Objectives: To clarify clinical presentations, diagnostic approaches, histological findings, response to treatment and the relationship with PeIN. Read More

    Novel Additions to the AJCC's New Staging Systems for Skin Cancer.
    Actas Dermosifiliogr 2017 Nov 18;108(9):818-826. Epub 2017 Jul 18.
    Servicio de Dermatología, Complejo Asistencial Universitario de Salamanca, Salamanca, España; IBSAL Instituto de Investigación Biomédica de Salamanca, Complejo Asistencial Universitario de Salamanca, Salamanca, España.
    The eighth edition of the staging manual of the American Joint Committee on Cancer incorporates important changes in the classification of skin cancers. Coming 40 years after the first edition, the latest manual preserves its specific system for Merkel cell carcinoma and takes into account recent publications on the prognosis of squamous cell carcinoma by defining a completely new T category for this neoplasm. Staging for squamous cell carcinoma considers head and neck tumors (excluding the eyelid) and does not offer solutions for other sites except the vulva, penis, and perianal region. Read More

    Neuroendocrine factors: The missing link in non‑melanoma skin cancer (Review).
    Oncol Rep 2017 Sep 13;38(3):1327-1340. Epub 2017 Jul 13.
    Laboratory of Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece.
    Non‑melanoma skin cancer (NMSC) is the most common form of cancer worldwide, comprising 95% of all cutaneous malignancies and approximately 40% of all cancers. In spite of intensive efforts aimed towards awareness campaigns and sun‑protective measures, epidemiological data indicate an increase in the incidence of NMSC. This category of skin cancers has many common environmental triggers. Read More

    Sarcomatoid Squamous Cell Carcinoma of the Penis - a Report of Two Cases.
    Folia Med (Plovdiv) 2017 06;59(2):232-237
    Department of Urology, Medical University of Plovdiv, Plovdiv, Bulgaria
    Background: Sarcomatoid (spindle cell) squamous cell carcinoma is a rare, highgrade, aggressive tumor consisting of the squamous cell carcinoma admixed with the malignant spindle cell (sarcomatoid) elements. These tumors are relatively uncommon in the genitourinary system and particularly in the penis.

    Materials And Methods: Two sarcomatoid squamous cell carcinomas of the penis were diagnosed in our hospital between 2012 and 2015. Read More

    Exophytic papillary penile cancer.
    Prog Urol 2017 Sep 4;27(10):564-566. Epub 2017 Jul 4.
    Department of pathology, hospital Juárez de México, Mexico City, Mexico.
    Penile carcinoma is a rare disease that has a wide range of pathology and morbidity. Occurs commonly in the 6th and 7th decades of life. Squamous cell carcinoma (SCC) is the predominant histological type. Read More

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