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    2180 results match your criteria Penile Squamous Cell Carcinoma

    1 OF 44

    Brachytherapy for Conservative Treatment of Invasive Penile Carcinoma: Prognostic Factors and Long-Term Analysis of Outcome.
    Int J Radiat Oncol Biol Phys 2017 Feb 28. Epub 2017 Feb 28.
    Brachytherapy Unit, Gustave Roussy, Villejuif, France; Radiotherapy Department, Gustave Roussy, Villejuif, France; Institut de Recherche Biomédicale des Armées, Bretigny-sur-Orge, France; French Military Health Academy, Ecole du Val-de-Grâce, Paris, France. Electronic address:
    Purpose: To report the largest experience with brachytherapy as a conservative approach for the treatment of penile carcinoma.

    Methods And Materials: We examined the outcomes of 201 patients treated at our institution over 45 years for invasive squamous cell carcinoma of the glans penis by brachytherapy.

    Results: With a median follow-up of 10. Read More

    Human Papillomavirus (HPV) Genotypes in Condylomas, Intraepithelial Neoplasia, and Invasive Carcinoma of the Penis Using Laser Capture Microdissection (LCM)-PCR: A Study of 191 Lesions in 43 Patients.
    Am J Surg Pathol 2017 Jun;41(6):820-832
    *Polytechnic School §School of Medicine, National University of Asunción †Instituto de Patología e Investigación, Asunción, Paraguay ‡DDL Diagnostic Laboratory, Rijswijk, The Netherlands ∥Miraca Life Sciences and Tufts University, Boston, MA.
    Laser capture microdissection-polymerase chain reaction (LCM-PCR) supported by p16 was used for the first time to demonstrate human papillomavirus (HPV) DNA in histologically specific penile lesions, which were as follows: squamous hyperplasia (12 lesions, 10 patients), flat lesions (12 lesions, 5 patients), condylomas (26 lesions, 7 patients), penile intraepithelial neoplasia (PeIN) (115 lesions, 43 patients), and invasive squamous cell carcinomas (26 lesions, 26 patients). HPV was detected by whole-tissue section and LCM-PCR. LCM proved to be more precise than whole-tissue section in assigning individual genotypes to specific lesions. Read More

    Clinicopathologic Characteristics and Treatment Outcomes of Penile Cancer.
    World J Mens Health 2017 Apr;35(1):28-33
    Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.
    Purpose: The aim of this study was to assess the clinicopathologic characteristics of penile cancer, including patterns of therapy, oncologic results, and survival.

    Materials And Methods: Between January 2005 and July 2015, 71 patients at 6 institutions who had undergone penectomy or penile biopsy were enrolled. Their medical records were reviewed to identify the mode of therapy, pathology reports, and cancer-specific survival (CSS) rate. Read More

    Co-infection of syphilis and hepatitis B with carcinoma penis in a human immunodeficiency virus male.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):78-80
    Department of STD, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India.
    Human immunodeficiency virus (HIV) infections have a high probability of co-infections with Syphilis and hepatitis B virus since they share the common routes of transmission. We report a 41-year-old HIV male (on antiretroviral therapy for the past 6 years) admitted for a complaint of penile ulcer for 2 months. Serology for syphilis and hepatitis B were positive. Read More

    Kinase analysis of penile squamous cell carcinoma on multiple platforms to identify potential therapeutic targets.
    Oncotarget 2017 Mar;8(13):21710-21718
    Department of Medicine, Section of Oncology, UAB School of Medicine, Birmingham, Alabama, USA.
    Penile squamous cell carcinoma (PSCC) is an orphan malignancy with poorly understood biology and suboptimal systemic therapy. Given that kinases may be drivers and readily actionable, we performed comprehensive multiplatform analysis of kinases in PSCC tumor and normal tissue. Fresh frozen tumors were collected from 11 patients with PSCC. Read More

    Pseudoepitheliomatous keratotic and micaceous balanitis treated with topical 5-fluorouracil and liquid nitrogen.
    Clin Exp Dermatol 2017 Apr 13. Epub 2017 Apr 13.
    Dermatology Department, National Skin Centre, Singapore.
    Pseudoepitheliomatous keratotic and micaceous balanitis (PKMB) is an uncommon premalignant condition involving the glans penis. We report the case of an 86-year-old man who presented with phimosis and pain on retracting his foreskin. He had previously undergone circumcision, which revealed a hyperkeratotic plaque with thin mica-like scales involving his glans penis. Read More

    HPV-negative penile squamous cell carcinoma: disruptive mutations in the TP53 gene are common.
    Mod Pathol 2017 Apr 7. Epub 2017 Apr 7.
    Institute of Pathology, Medical University of Graz, Graz, Austria.
    The majority of penile squamous cell carcinomas is caused by transforming human papilloma virus (HPV) infection. The etiology of HPV-negative cancers is unclear, but TP53 mutations have been implicated. Archival tissues of 108 invasive squamous cell carcinoma from a single pathology institution in a low-incidence area were analyzed for HPV-DNA and p16(ink4a) overexpression and for TP53 mutations by ion torrent next-generation sequencing. Read More

    Human papillomavirus 16 is an aetiological factor of scrotal cancer.
    Br J Cancer 2017 Apr 4;116(9):1218-1222. Epub 2017 Apr 4.
    Research and Development, DDL Diagnostic Laboratory, Rijswijk, The Netherlands.
    Background: Squamous cell scrotal carcinoma (SCSC) is an infrequent skin cancer associated historically with occupational carcinogens. Human papillomavirus (HPV) DNA has been associated with SCSC but there is no definitive proof of its oncogenic role.

    Methods: Human papillomavirus-DNA and -E6*I mRNA were analysed in six invasive histologically typed SCSC. Read More

    Disparity between pre-existing management of penile cancer and NCCN guidelines.
    Urol Oncol 2017 Mar 28. Epub 2017 Mar 28.
    Department of Urology, UH Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, OH; Division of Urology, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH. Electronic address:
    Objective: To determine the locoregional management of penile cancer before the introduction of NCCN guidelines and how much shift in practice patterns is required to meet the guidelines.

    Methods: The National Cancer Data Base was queried to identify 6,396 patients with squamous cell carcinoma of the penis diagnosed between 2004 and 2013. The cohort was divided into management groups based on the NCCN guidelines: cTa and cTis (cTa/is), pT1 low grade (T1LG), pT1 high grade (T1HG), and pT2 or greater (T234). Read More

    Strong association of insulin-like growth factor 1 receptor expression with histologic grade, subtype, and HPV status in penile squamous cell carcinomas: a tissue microarray study of 112 cases.
    Virchows Arch 2017 Mar 27. Epub 2017 Mar 27.
    Centro para el Desarrollo de la Investigación Científica (CEDIC), Asunción, Paraguay.
    Insulin-like growth factor-1 receptor (IGF1R) plays a key role in cell growth and transformation. It is overexpressed in several solid tumors. This study evaluates IGF1R immunoexpression in penile squamous cell carcinoma (SCC). Read More

    Evolution of the Histo-Epidemiological Profile of Urological Cancers in Togo
    Asian Pac J Cancer Prev 2017 02 1;18(2):491-494. Epub 2017 Feb 1.
    Department of Pathology, the University Teaching Hospital of Lomé, Togo.
    Background: Urological cancers are an important public health issue and pose problems with diagnosis and adequate management in developing countries. Our aim was to determine and report epidemiological and histological features of urological cancers in Togo. Materials and methods: A retrospective descriptive study was conducted of cases of urological cancers observed in the laboratory of pathological anatomy of the CHU Tokoin over the last 4 years (2012-2016). Read More

    Tumor PD-L1 expression is correlated with increased TILs and poor prognosis in penile squamous cell carcinoma.
    Oncoimmunology 2017 22;6(2):e1269047. Epub 2016 Dec 22.
    Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China; State Key Laboratory of Oncology in Southern China, Guangzhou, P.R. China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, P.R. China.
    Despite its rare incidence worldwide, penile squamous cell carcinoma (PeSCC) still presents with significant morbidity and mortality due to the limited treatment options for advanced patients, especially those in developing countries. The program death-1 (PD-1)/PD-1 ligand (PD-L1) axis has been demonstrated to play an important role in tumor immune escape, and immunotherapies targeting this pathway have shown great success in certain cancer types. Here, we analyzed the expression pattern of PD-L1 in tumor cells and tumor-infiltrating lymphocytes (TILs) in PeSCC with a multi-center cohort. Read More

    Clinical Outcomes of Perioperative Chemotherapy in Patients With Locally Advanced Penile Squamous-Cell Carcinoma: Results of a Multicenter Analysis.
    Clin Genitourin Cancer 2017 Feb 27. Epub 2017 Feb 27.
    UAB Comprehensive Cancer Center, Birmingham, AL.
    Background: The prognosis of patients with locally advanced penile squamous-cell carcinoma is primarily related to the extent of lymph node metastases. Surgery alone yields suboptimal results, and there is a paucity of data on these patients' outcomes.

    Patients And Methods: This retrospective study evaluated patients who received neoadjuvant or adjuvant chemotherapy from 1990 onward at 12 centers. Read More

    Medullary Carcinoma of the Penis: A Distinctive HPV-related Neoplasm: A Report of 12 Cases.
    Am J Surg Pathol 2017 Apr;41(4):535-540
    *Instituto de Patología e Investigación §School of Medicine, National University of Asuncion - UNA, Asunción, Paraguay †Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO)-IDIBELL, L'Hospitalet de Llobregat, Gran Via de l'Hospitalet, Barcelona ‡CIBER Epidemiology and Public Health, Madrid, Spain ∥Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston, TX ¶National Institute of Cancer, Bogotá, Colombia #DDL Diagnostic Laboratory, Rijswijk, The Netherlands.
    A third to half of penile invasive squamous cell carcinomas are human papillomavirus (HPV) related. Warty (condylomatous), warty-basaloid, and basaloid carcinomas are the most common subtypes associated with HPV. Less frequent are clear cell and lymphoepithelioma-like carcinomas. Read More

    The importance of microvessel density in predicting cancer progression in patients with penile squamous cell carcinoma.
    Int Urol Nephrol 2017 Jun 13;49(6):1007-1014. Epub 2017 Mar 13.
    , Lucknow, India.
    Purpose: To evaluate the role of microvessel density (MVD) in predicting lymph node (LN) metastasis in penile squamous cell carcinoma (PSCC).

    Materials And Methods: Records of 266 patients with PSCC were analyzed. Parameters examined were tumor stage, grade, nodal status, intratumoral and peritumoral MVD. Read More

    Human Papillomavirus and the Development of Different Cancers.
    Cytogenet Genome Res 2016 1;150(3-4):185-193. Epub 2017 Mar 1.
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
    Human papillomaviruses (HPV) are responsible for the development of almost all cervical cancers. HPV is also found in 85% of anal cancer and in 50% of penile, vulvar, and vaginal cancers, and they are increasingly found in a subset of head and neck cancers, i.e. Read More

    Penile squamous cell carcinoma: a review of the literature and case report treated with Mohs micrographic surgery.
    An Bras Dermatol 2017 Jan-Feb;92(1):95-99
    Department of Dermatology - State University of New York - Downstate and Veterans Affairs Medical Center - Brooklyn (NY), United States.
    The majority of penile carcinoma is squamous cell carcinoma. Although uncommon in the United States, it represents a larger proportion of cancers in the underdeveloped world. Invasive squamous cell carcinoma may arise from precursor lesions or de novo , and has been associated with lack of circumcision and HPV infection. Read More

    Inguinal lymph node presenting as the delayed site of metastasis in early stage endometrial carcinoma: Case report.
    Int J Surg Case Rep 2017 19;32:12-15. Epub 2017 Jan 19.
    Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, 59046, Saudi Arabia. Electronic address:
    Introduction: Inguinal lymph nodes are the frequent sites of metastasis for malignant lymphoma, squamous cell carcinoma of anal canal, vulva and penis, malignant melanoma and squamous cell carcinoma of skin over lower extremities or trunk. Anatomically, endometrial carcinoma is less likely to spread to the superficial or deep inguinal lymph nodes, thus metastatic involvement of these lymph nodes can easily be overlooked.

    Case Presentation: Here-in we report a case of a 65-year old Saudi morbid obese female, who presented with left inguinal lymphadenopathy as initial delayed site of metastasis almost 19 months after the initial treatment for FIGO IA endometrial carcinoma. Read More

    Complete Remission of Locally Advanced Penile Squamous Cell Carcinoma after Multimodality Treatment.
    Rare Tumors 2016 Nov 20;8(4):6651. Epub 2016 Dec 20.
    National Taiwan University School of Medicine , Taipei, Taiwan.
    Treatment of locally advanced penile squamous cell carcinoma (pSCC) remains highly controversial secondary to disease rarity and lack of prospective randomized controlled trials. The current mainstays of care are multi-modality treatment with neoadjuvant chemotherapy and surgery. However, clinicians often have difficulty making recommendations for patients unable to tolerate chemotherapy or surgery due to scarcity of data to guide clinical decision-making. Read More

    Warty Carcinoma Penis: An Uncommon Variant.
    Case Rep Pathol 2017 5;2017:2937592. Epub 2017 Jan 5.
    Department of Pathology, Manipal College of Medical Sciences, Pokhara, Nepal.
    Penile carcinoma frequency varies widely in different parts of the world and comprises 1-10% of all the malignancies in males. Majority of the cases of penile carcinoma are squamous cell carcinoma of penis comprising 60% to 70% of all cases. Warty carcinoma of penis is an unusual neoplasm and a variant of penile squamous cell carcinoma comprising 5%-10% of all the variants. Read More

    Role of the Common Fragile Sites in Cancers with a Human Papillomavirus Etiology.
    Cytogenet Genome Res 2016 1;150(3-4):217-226. Epub 2017 Feb 1.
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
    High-risk human papillomaviruses (HPVs) are known to be associated with different anogenital cancers including cervical, anal, penile, and vaginal cancers. They are also found to be responsible for the dramatic increases in oropharyngeal squamous cell carcinoma (OPSCC) observed in the United States and Europe. The model for how high-risk HPVs induce cancer formation comes from studies of cervical cancer which usually involves integration of the HPV into the human genome and subsequent changes due to induced chromosomal instability. Read More

    Sarcomatoid Carcinoma of the Penis.
    Indian J Surg Oncol 2017 Mar 6;8(1):85-87. Epub 2016 Jun 6.
    Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India.
    Sarcomatoid carcinomas are biphasic tumours, which occur at any site in the human body. It rarely affects the penis, with only 38 cases being reported in literature. It may be considered as a variant of squamous cell carcinoma or a dedifferentiated tumour. Read More

    Penile Cancer: Contemporary Lymph Node Management.
    J Urol 2017 Jun 20;197(6):1387-1395. Epub 2017 Jan 20.
    Department of Surgery, University of Melbourne, Heidelberg, Victoria, Australia; Ludwig Institute for Cancer Research, Melbourne, Victoria, Australia.
    Purpose: In penile cancer, the optimal diagnostics and management of metastatic lymph nodes are not clear. Advances in minimally invasive staging, including dynamic sentinel lymph node biopsy, have widened the diagnostic repertoire of the urologist. We aimed to provide an objective update of the recent trends in the management of penile squamous cell carcinoma, and inguinal and pelvic lymph node metastases. Read More

    Identification of HPV Types and Mycobacterium Tuberculosis Complex in Historical Long-Term Preserved Formalin Fixed Tissues in Different Human Organs.
    PLoS One 2017 23;12(1):e0170353. Epub 2017 Jan 23.
    Institute of Pathology, University Medicine of Rostock, Rostock, Germany.
    University anatomical-pathological collections represent huge sources of human tissues and preparations from a variety of different diseases. With the help of modern genetic and histological methods, preserved fixed tissues from pathological collections can be used to re-evaluate former diagnoses. We analysed 25 specimens from our pathological collection with ages ranging from 78 to 112 years. Read More

    Dynamic sentinel node biopsy for penile cancer: an initial experience in an Irish Hospital.
    Ir J Med Sci 2017 Jan 19. Epub 2017 Jan 19.
    Department of Urology, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland.
    Background: The presence of nodal metastases is the single most important prognostic factor in penile cancer. However, reliable assessment of nodal status in clinically node-negative (cN0) patients poses a challenge. Approximately 20% of these patients harbour occult nodal metastases. Read More

    Penile metastasis from primary transitional cell carcinoma of the bladder sparing the urethra.
    Can Urol Assoc J 2016 Nov-Dec;10(11-12):E392-E394. Epub 2016 Nov 10.
    Division of Urology, Memorial University of Newfoundland, St. John's, NL, Canada.
    Metastatic involvement of the penis is relatively infrequent. Metastasis of transitional cell carcinoma (TCC) is extremely rare. We report a case of bladder TCC with metastases to the penis that spares the urethra - a finding that, to the best of our knowledge, has not been previously reported. Read More

    Human papillomavirus types 44, 52, 66 and 67 detected in a woman with squamous cell carcinoma of the urinary bladder.
    Scand J Urol 2017 Feb 13;51(1):85-86. Epub 2017 Jan 13.
    a Department of Urology , Aarhus University Hospital , Aarhus, Denmark.
    Human papillomavirus (HPV) is an accepted causative agent in cervical cancer of the uterus, penile cancer, anal cancer and oropharyngeal carcinomas, while its role in other cancers such as urinary bladder cancer is still much discussed. This report presents a patient with multiple HPV types in a squamous cell carcinoma of the urinary bladder. Read More

    Verruciform xanthoma of the penis: A rare benign lesion that simulates carcinoma.
    Arch Ital Urol Androl 2016 Dec 30;88(4):284-285. Epub 2016 Dec 30.
    Department of Urology, IRCCS San Martino, University of Genova.
    Verruciform xanthoma is a rare and benign condition predominantly affecting the oral cavity, but also skin and female anogenital mucosa. It can be flat, papular-warty or crateriform-cystic. Furthermore it can simulate HPV viral lesion such as condyloma and malignant neoplasia such as verrucous squamous cell carcinoma. Read More

    Prognostic and Predictive Factors in Patients with Advanced Penile Cancer Receiving Salvage (2nd or Later Line) Systemic Treatment: A Retrospective, Multi-Center Study.
    Front Pharmacol 2016 20;7:487. Epub 2016 Dec 20.
    Section of Hematology-Oncology, Department of Medicine, University of Alabama at Birmingham Comprehensive Cancer Center Birmingham, AL, USA.
    Introduction and objectives: Metastatic penile squamous cell carcinoma (PSCC) is associated with dismal outcomes with median overall survival (OS) of 6-12 months in the first-line and <6 months in the salvage setting. Given the rarity of this disease, randomized trials are difficult. Prognostic risk models may assist in rational drug development by comparing observed outcomes in nonrandomized phase II studies and retrospective data vs. Read More

    Prostate-specific Membrane Antigen-targeted Ligand Positron Emission Tomography/Computed Tomography and Immunohistochemical Findings in a Patient With Synchronous Metastatic Penile and Prostate Cancer.
    Urology 2017 Mar 4;101:e5-e6. Epub 2017 Jan 4.
    Department of Urology, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Dresden, Germany.
    A 68-year-old man presented with synchronous metastatic penile and prostate cancer. 68Ga-labeled prostate-specific membrane antigen-targeted ligand positron emission tomography/computed tomography (PSMA-PET/CT) revealed tracer uptake in inguinal, pelvic, and retroperitoneal metastases. Lymph node biopsies and immunohistochemical staining revealed that both cancers involved the lymph nodes and expressed PSMA. Read More

    The Patterns of Practice and Outcomes of Penile Cancer in Ontario.
    Clin Oncol (R Coll Radiol) 2017 Apr 3;29(4):239-247. Epub 2017 Jan 3.
    Department of Oncology, Queen's University, Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston, Ontario, Canada.
    Aims: Penile cancer is a rare malignancy in Western countries. The management guidelines are mainly derived from retrospective studies as there are no randomised trials. The primary objective of this study was to assess patterns of practice and outcomes of penile squamous cell carcinoma in Ontario. Read More

    Development of Squamous Cell Carcinoma of Buccal Mucosa Graft Used for Urethroplasty: A Case Report.
    Urol Case Rep 2017 Jan 11;10:60-62. Epub 2016 Dec 11.
    Department of Urology, University of Florida, USA.
    Urethroplasty may involve the use of tissue substitution including buccal mucosa graft (BMG), penile fasciocutaneous flaps, or skin grafts. Stricture recurrence and fistula formation are some uncommon complications that can result from surgery. The development of squamous cell carcinoma (SCC) after BMG substitution urethroplasty is a new complication that we encountered that has not been described in the literature. Read More

    [A Case of Penile Squamous Cell Carcinoma, Sarcomatoid Subtype].
    Hinyokika Kiyo 2016 Oct;62(10):553-556
    The Department of Urology, Japan Community Healthcare Organization Hoshigaoka Medical Center.
    A 70-year-old man was referred to our department for further examination and treatment of a painless penile mass of about 2cm. The patient first noticed the mass onlya few weeks before presentation. Diagnostic biopsy was interpreted as leiomyosarcoma. Read More

    Erythroplasia of Queyrat treated with methyl aminolevulinate-photodynamic therapy (MAL-PDT): case report and review of the literature.
    G Ital Dermatol Venereol 2016 Dec 1. Epub 2016 Dec 1.
    Dermatology Unit "Daniele Innocenzi", Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, Terracina, Latina, Italy -
    Erythroplasia of Queyrat (EQ) is a rare disease involving the mucosal and transitional surfaces of the penis. Effective treatment is necessary to minimize progression to squamous cell carcinoma. The standard therapy for EQ, partial or radical penectomy, is invasive; photodynamic therapy (PDT) may be an effective, non-surgical tissue-sparing option. Read More

    Epidermal growth factor receptor as an adverse survival predictor in squamous cell carcinoma of the penis.
    Hum Pathol 2017 Mar 15;61:97-104. Epub 2016 Nov 15.
    Department of Anatomic Pathology, A.C. Camargo Cancer Center, 01508-010, São Paulo, SP, Brazil; General Pathology, Faculty of Dentistry, University of São Paulo, 05508-000, São Paulo, SP, Brazil. Electronic address:
    Penile carcinoma (PC) is more frequent in underdeveloped countries, generally is diagnosed at an advanced stage when therapeutic options are restricted, and thus is associated with high morbidity/mortality rates. Recent studies have demonstrated clinical benefits with epidermal growth factor receptor (EGFR)-targeted therapy in patients with PC, although there is no test that provides accurate patient selection. The aim of the present study was to evaluate the prognostic value of EGFR gene and protein status in tumor samples from patients with primary penile squamous cell carcinoma. Read More

    [CCAFU french national guidelines 2016-2018 on penile cancer].
    Prog Urol 2016 Nov;27 Suppl 1:S167-S179
    Comité de cancérologie de l'Association française d'urologie, groupe organes génitaux externes, maison de l'urologie, 11, rue Viète, 75017 Paris, France.
    Introduction: The aim of this work is to establish guidelines proposed by the external genital organ group of the CCAFU for the diagnosis, treatment and follow-up of penile cancer.

    Material And Methods: The multidisciplinary working party studied 2013 guidelines exhaustively reviewed the literature, and evaluated references and their level of proof in order to attribute grades of recommandation.

    Results: The most common histological type is squamous cell carcinoma. Read More

    The Danish National Penile Cancer Quality database.
    Clin Epidemiol 2016 25;8:589-594. Epub 2016 Oct 25.
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus Nord, Denmark.
    Aim Of Database: The Danish National Penile Cancer Quality database (DaPeCa-data) aims to improve the quality of cancer care and monitor the diagnosis, staging, and treatment of all incident penile cancer cases in Denmark. The aim is to assure referral practice, guideline adherence, and treatment and development of the database in order to enhance research opportunities and increase knowledge and survival outcomes of penile cancer.

    Study Population: The DaPeCa-data registers all patients with newly diagnosed invasive squamous cell carcinoma of the penis in Denmark since June 2011. Read More

    Down-regulation of microRNA-146a is associated with high-risk human papillomavirus infection and epidermal growth factor receptor overexpression in penile squamous cell carcinoma.
    Hum Pathol 2017 Mar 4;61:33-40. Epub 2016 Nov 4.
    Department of Molecular Medicine, University of Padova, I-35121 Padova, Italy. Electronic address:
    Dysregulation of host microRNA expression has been involved in the development and progression of human papillomavirus (HPV)-related tumors. Analysis of miR-146a expression in a series of 59 penile squamous cell carcinomas (PSCCs) showed that its levels were lower in high-risk HPV-positive than in HPV-negative PSCCs and inversely correlated with expression of epidermal growth factor receptor (EGFR), a known target for miR-146a. Analysis of genotype distribution for rs2910164, a common functional polymorphism of miR-146a, did not identify correlations with miR-146a levels and EGFR expression in PSCCs. Read More

    Volume-outcome relationship in penile cancer treatment: a population based patterns of care and outcomes study from Australia.
    BJU Int 2016 Oct;118 Suppl 3:35-42
    Cancer Research Division, NSW Cancer Council, Sydney, Australia.
    Objectives: To study the patterns of care of penile cancer diagnosed in the state of New South Wales (NSW) over a 10 year period and determine factors that are associated with differences in survival.

    Patients And Methods: All invasive penile cancer diagnosed between 2001 and 2009 in NSW, Australia, were identified from the Central Cancer Registry. Records of treatment from the Admitted Patient Data Collection and deaths from the Registry of Births Deaths and Marriages were electronically linked. Read More

    Bilateral pelvic lymph node dissection for Chinese patients with penile cancer: a multicenter collaboration study.
    J Cancer Res Clin Oncol 2017 Feb 22;143(2):329-335. Epub 2016 Oct 22.
    Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China.
    Background: Current guidelines recommend pelvic lymphadenectomy (PLND) for patients with pelvic lymph node metastasis and special state. However, these data and recommendations do not distinguish the role of PLND in different patient groups and confirm the final benefits. The aim of this study was to confirm the efficacy of pelvic lymphadenectomy (PLND) for the different groups of patients. Read More

    Searching beyond the usual papillomavirus suspects in squamous carcinomas of the vulva, penis and head and neck.
    Infect Genet Evol 2016 Nov 4;45:198-204. Epub 2016 Sep 4.
    Infections and Cancer Laboratory, Catalan Institute of Oncology (ICO) L'Hospitalet de Llobregat, Barcelona, Spain; Bellvitge Institute of Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; MIVEGEC, National Center for Scientific Research (CNRS), Montpellier, France. Electronic address:
    Human Papillomaviruses (HPVs) are involved in the etiology of anogenital and head and neck cancers. The HPV DNA prevalence greatly differs by anatomical site. Indeed, the high rates of viral DNA prevalence in anal and cervical carcinomas contrast with the lower fraction of cancer cases attributable to HPVs in other anatomical sites, chiefly the vulva, the penis and head and neck. Read More

    Factors associated with regional recurrence after lymph node dissection for penile squamous cell carcinoma.
    BJU Int 2017 Apr 8;119(4):591-597. Epub 2016 Nov 8.
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Objective: To identify factors associated with regional recurrence after lymph node dissection (LND) for squamous cell carcinoma (SCC) to determine which patients might benefit from adjuvant therapy.

    Patients And Methods: Men who underwent LND for penile SCC from 1977 to 2014 were identified from an institutional database. Kaplan-Meier curves estimated recurrence-free survival (RFS) calculated from the date of LND. Read More

    Glansectomy and Split-thickness Skin Graft for Penile Cancer.
    Eur Urol 2016 Oct 13. Epub 2016 Oct 13.
    Department of Urology and NIHR Biomedical Research Centre at University College London Hospitals, London, UK. Electronic address:
    Background: Penile cancer is a rare malignancy that is confined to the glans in up to four out of five cases. Although descriptions of glansectomy exist, there are no contemporary video explanations or large published single centre series.

    Objective: To show the efficacy and safety of glansectomy and split-thickness skin graft (STSG) reconstruction. Read More

    Management of non-visualization following dynamic sentinel lymph node biopsy for squamous cell carcinoma of the penis.
    BJU Int 2017 Apr 21;119(4):573-578. Epub 2016 Dec 21.
    Department of Urology and NIHR Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, UK.
    Objectives: To review the management and clinical outcomes of uni- or bilateral non-visualization of inguinal lymph nodes during dynamic sentinel lymph node biopsy (DSNB) in patients diagnosed with penile cancer and clinically impalpable inguinal lymph nodes (cN0), and to develop an algorithm for the management of patients in which non-visualization occurs.

    Patients And Methods: This is a retrospective observational study over a period of 4 years, comprising 166 patients with penile squamous cell carcinoma undergoing DSNB and followed up for a minimum of 6 months. All cases diagnosed with uni- or bilateral non-visualization of sentinel nodes in this cohort were identified from a penile cancer database. Read More

    Surgical Management of Primary Scrotal Cancer.
    Urol Clin North Am 2016 Nov 3;43(4):531-544. Epub 2016 Sep 3.
    Department of Urology, Emory University, 1365 Clifton Road Northeast, Suite B6140, Atlanta, GA 30322, USA.
    Primary scrotal cancer is a rare urologic malignancy with various histologic subtypes. Management and outcomes are not designed optimally. Surgical excision is the recommended treatment for localized scrotal cancer, with assessment of the margins for disease. Read More

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