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Pathogens 2022 Jun 1;11(6). Epub 2022 Jun 1.

Laboratory of Oncovirology, Department of Microbiology, Instituto de Ciências Biomédicas, Universidade de São Paulo, Sao Paulo 05508-900, Brazil.

Infection with some mucosal human papillomavirus (HPV) types is the etiological cause of cervical cancer and of a significant fraction of vaginal, vulvar, anal, penile, and head and neck carcinomas. DNA repair machinery is essential for both HPV replication and tumor cells survival suggesting that cellular DNA repair machinery may play a dual role in HPV biology and pathogenesis. Here, we silenced genes involved in DNA Repair pathways to identify genes that are essential for the survival of HPV-transformed cells. Read More

Cancers (Basel) 2022 Jun 18;14(12). Epub 2022 Jun 18.

Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT 84132, USA.

Concurrently acquired positron emission tomography and computed tomography (PET-CT) is an advanced imaging modality with diverse oncologic applications, including staging, therapeutic assessment, restaging and longitudinal surveillance. This series of six review articles focuses on providing practical information to providers and imaging professionals regarding the best use and interpretative strategies of PET-CT for oncologic indications in adult patients. In this fourth article of the series, the more common gynecological and adult genitourinary malignancies encountered in clinical practice are addressed, with an emphasis on Food and Drug Administration (FDA)-approved and clinically available radiopharmaceuticals. Read More

J Cancer Res Clin Oncol 2022 Jun 21. Epub 2022 Jun 21.

Department of Urology, St. Elisabeth-Clinic Straubing, Brothers of Mercy Hospital, Straubing, Germany.

Urology 2022 Jun 16. Epub 2022 Jun 16.

MS General Surgery, Senior Resident (Academic), Department of Urology, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India. Electronic address:

Objectives: To describe our modified technique of performing video endoscopic inguinal lymphadenectomy (VEIL) with the proposed benefits of a shallow learning curve and better ergonomics.

Methods: We describe our modified VEIL technique: the deep first approach, in a squamous cell carcinoma penis patient with a pathological T3 disease and bilateral palpable, mobile inguinal lymph nodes post penectomy.

Results: The surface markings and the port incision sites for the procedure were conventional. Read More

Hum Pathol 2022 Jun 14. Epub 2022 Jun 14.

Department of Pathology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India, 400012. Electronic address:

Staging based on the tumor (T), node (N), and metastasis (M) schema of the American Joint Committee on Cancer (AJCC) is usually the most important prognostic factor for any tumor type. Although a rare tumor, in penile cancers, this staging has evolved rapidly in the last two editions of the AJCC Cancer Staging manuals. These changes and updates are largely based on the advancement in our knowledge of the complex anatomy of the penis, the role of histopathological variables in disease biology, and the results of multicentric studies comprising large datasets. Read More

Asian J Androl 2022 06 7. Epub 2022 Jun 7.

College of Medicine and Public Health, Flinders University, Bedford Park, South Australia 5042, Australia.

BJU Int 2022 Jun 15. Epub 2022 Jun 15.

Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.

Objectives: To evaluate the anti-tumor activity and the safety of anti-PD-1 antibody plus EGFR blockade combined with platinum-based chemotherapy (PEP) as first-line therapy for stage IV PSCC.

Patients And Methods: Retrospective review of 17 patients with stage IV PSCC undergoing first-line PEP at Sun Yat-sen University Cancer Center between January 2018 and September 2021. Clinical responses were assessed by the RECIST version 1. Read More

Cancer Epidemiol Biomarkers Prev 2022 Jun 14. Epub 2022 Jun 14.

McGill University, Montreal, QC, Canada.

Background: Cervical cancer is the fourth leading cause of death among women worldwide, with 85% of the burden falling on low- to middle- income countries. We studied the correlates of cervical cancer incidence and mortality, and case-fatality in Sub-Saharan Africa.

Methods: Country-level data on 16 putative cervical cancer correlates for 37 Sub-Saharan African countries were collected from publicly available data sources. Read More

Med Dosim 2022 Jun 10. Epub 2022 Jun 10.

Department of Radiation Oncology, Lucien Neuwirth Cancer Centre, Saint Priest en Jarez, France; Department of Research and Teaching in Oncology, Lucien Neuwirth Cancer Centre, Saint Priest en Jarez, France; Molecular and Cellular Radiobiology Lab, CNRS UMR 5822, Institut de Physique Nucléaire de Lyon, IPNL, 69622 Lyon Medicine University, Lyon, France.

Preserving the quality of life and sexual function of patients with a localized prostate cancer remains a challenge for physicians and a major issue for patients. The present study aimed at demonstrating the feasibility of a dosimetric preservation of the sexual organs during prostate stereotactic radiotherapy planning. Patients from a single centre were retrospectively included in the RPAH-2 trial and randomized in Arm B if they presented with either a low- or intermediate- risk prostate cancer. Read More

Transl Androl Urol 2022 May;11(5):683-693

Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Background: Due to the unique anatomy and complex function of the penis, the reconstruction of penile defect is fraught with great challenges. The current standard methods are limited by numerous complications and insufficient donor sites. While functional vascularized penile tissue engineering offers a novel way to address this problem, revascularization remains the primary concern. Read More

Can J Urol 2022 Jun;29(3):11128-11135

NYU Langone Department of Urology, New York, New York, USA.

Introduction: Given the increasing interest in partial gland cryo-ablation as a treatment modality and the lack of data surrounding urinary and sexual outcomes after the procedure, the goal of this analysis was to assess functional outcomes following partial gland cryo-ablation (PGCA) stratified according to baseline severity of lower urinary tract symptoms (LUTS) and erectile function (EF). A secondary goal was to also determine if there were any clinical factors associated with significant change in LUTS and EF.

Materials And Methods: Since 3/2017, all men undergoing primary PGCA were offered enrollment into an IRB-approved prospective outcomes registry. Read More

Cancers (Basel) 2022 Jun 6;14(11). Epub 2022 Jun 6.

Translational Medicine Laboratory, Department of Cancer Research, Instituto Oncologico Fundacion Arturo Lopez Perez, Santiago 8320000, Chile.

Penile, vulvar and anal neoplasms show an incidence lower than 0.5% of the population per year and therefore can be considered as rare cancers but with a dramatic impact on quality of life and survival. This work describes the experience of a Chilean cancer center using multiplexed immunofluorescence to study a case series of four penile cancers, two anal cancers and one vulvar cancer and simultaneous detection of CD8, CD68, PD-L1, Cytokeratin and Ki-67 in FFPE samples. Read More

Front Surg 2022 18;9:882011. Epub 2022 May 18.

Division of Cancer Surgery, Peter MacCallum Cancer Center, Melbourne, VIC, Australia.

Penile squamous cell carcinoma (SCC) is a rare malignancy, which is known to invade local inguinal lymph nodes prior to progressing to the pelvis. Dynamic sentinel lymph node biopsy (DSLNB) is a standard for the minimally invasive assessment of lymphadenopathy in patients with subclinical groin metastasis. Hybrid Tc Single-Photon Emission Computed Tomography (SPECT-CT) has been shown to increase the accuracy of identifying first draining "sentinel" nodes (SN). Read More

Urol Oncol 2022 May 31. Epub 2022 May 31.

Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL. Electronic address:

Objective: Patient reports of their symptom burden (i.e., patient-reported outcomes or PROs) have been shown to direct clinicians' ability to personalize care and improve outcomes. Read More

Int J Surg Case Rep 2022 May 4;94:107167. Epub 2022 May 4.

Pathology Anatomy Department, Hasan Sadikin Academic Medical Center, Universitas Padjadjaran, Bandung, Indonesia.

Introduction An Importance: Testicular epidermoid cysts (TECs) are rare benign testicular neoplasms. Recently, testicular epidermoid cysts (TECs) are listed as teratoma of prepubertal type, however it is still difficult to differentiate the epidermoid cyst from malign testicular tumor. Therefore, we would like to report testicular epidermoid cyst at our institution. Read More

Semin Oncol Nurs 2022 Jun 30;38(3):151287. Epub 2022 May 30.

Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN.

Background: Penile cancer is an uncommon malignancy in the United States and most developed countries, with higher incidence in the developing nations of Africa, Asia, and South America. Standard treatment involves a urologist, medical oncologist, and radiation oncologist to deliver multimodal treatment in an integrated fashion. This article will discuss the patterns of specialty referral that are important for men affected by penile cancer. Read More

Front Oncol 2022 13;12:812008. Epub 2022 May 13.

Oncology Research Center, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil.

Penile cancer (PC) still presents a health threat for developing countries, in particular Brazil. Despite this, little progress has been made on the study of markers, including molecular ones, that can aid in the correct management of the patient, especially concerning lymphadenectomy. As in other neoplasms, non-coding RNAs (ncRNAs) have been investigated for penile cancer, with emphasis on microRNAs, piRNAs (PIWI-interacting small RNAs), and long non-coding RNAs (LncRNAs). Read More

Adv Radiat Oncol 2022 May-Jun;7(3):100860. Epub 2021 Nov 28.

Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

Int J Urol 2022 May 28. Epub 2022 May 28.

Department of Urology, Faculty of Life Sciences Kumamoto University, Kumamoto, Japan.

Penile cancer is a rare cancer for which no medical guidelines have been established before in Japan. These guidelines aim to standardize, as much as possible, the therapeutic modality for penile cancer, for which empirical evidence is limited on a global scale, thereby bolstering therapeutic outcomes for patients with penile cancer. The new guidelines conform to the Minds Guide for Developing Clinical Practice Guidelines (2017) as much as possible. Read More

Semin Oncol Nurs 2022 Jun 25;38(3):151283. Epub 2022 May 25.

Department of Uro-oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India. Electronic address:

Objectives: Penile cancer is a rare malignancy with a dichotomy between its incidence and evidence generation. The objective of this review is to highlight the points of consensus and divergences in penile cancer care and suggest areas where further research is needed to standardize treatment protocols.

Data Sources: International guidelines and articles in PubMed and Medline were searched for studies on various aspects of penile cancer care. Read More

Semin Oncol Nurs 2022 Jun 25;38(3):151286. Epub 2022 May 25.

Department of Urology, College of Medicine, University of Arizona, Tucson.

Objective: In this article we review the quality of life and the psychosocial and functional outcomes experienced by patients and their partners following penile cancer diagnosis and treatment.

Data Sources: A literature search for primary articles related to patient reported outcomes following penile cancer treatment was conducted using the electronic database PubMed.

Conclusion: Penile cancer is a rare malignancy in the United States, and it carries an excellent prognosis if diagnosed early. Read More

J Epidemiol Glob Health 2022 May 31. Epub 2022 May 31.

Surgical Oncology Department, BP-A Beneficência Portuguesa de São Paulo, São Paulo, Brazil.

Background: Considering the socioeconomic disparities and inequalities observed in the healthcare resources among the Brazilian regions, we aimed to analyze the mortality trends of urological cancers in Brazil to identify areas with differential risks.

Methods: Deaths related to prostate (PCa), bladder (BCa), kidney (KC), penile (PeC), and testis (TCa) cancers from 1996 to 2019 were retrieved from the Mortality Information System database (Brazil). Geographic and temporal patterns were analyzed using age-standardized mortality rates (ASMRs). Read More

J Sex Med 2022 Jul 23;19(7):1196-1200. Epub 2022 May 23.

Department of Oncologic Urology, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:

Background: Magnetic resonance-guided adaptive radiotherapy (MRgRT) enables neurovascular-sparing treatment for localized prostate cancer (PCa). The aim of this treatment is preservation of erectile function by sparing the neurovascular bundles, the internal pudendal arteries, the corpora cavernosa, and the penile bulb. Internal pudendal arteries, corpora cavernosa, and penile bulb sparing can generally be achieved in all patients, but NVB sparing can be challenging due to its proximity to the prostate and is therefore dependent on tumor location. Read More

Front Surg 2022 9;9:814832. Epub 2022 May 9.

Department of Abdominal and General Surgery and Oncology, National Cancer Institute, Vilnius, Lithuania.

Background: Metastatic involvement of the penis in cases of rectal cancer is exceptionally rare condition. Our clinical case report and review of the literature will contribute in complementing currently limited data on penile metastasis from rectal cancer.

Case Report: We report a case of a 64-year-old male diagnosed with penile metastasis from rectal cancer. Read More

Semin Oncol Nurs 2022 Jun 22;38(3):151288. Epub 2022 May 22.

Medical Oncology Division and Palliative Care Division, Department of Internal Medicine, University of Kansas Medical Center, Westwood, KS.

Objectives: We aim to review the benefits of palliative care, describe why a palliative approach to care is needed for patients with advanced penile squamous cell carcinoma and propose ways in which oncology nurses can improve access to and provision of palliative care.

Data Sources: A review of the literature was performed and identified a range of randomized trials and systematic reviews regarding the benefits of palliative care in this patient group. Cohort studies of patients with penile cancer were used to describe the psychosocial and physical disease burden of penile cancer. Read More

Phys Med Biol 2022 06 10;67(12). Epub 2022 Jun 10.

Department of Medical Biophysics, University of Toronto, Canada.

Machine learning (ML) based radiation treatment planning addresses the iterative and time-consuming nature of conventional inverse planning. Given the rising importance of magnetic resonance (MR) only treatment planning workflows, we sought to determine if an ML based treatment planning model, trained on computed tomography (CT) imaging, could be applied to MR through domain adaptation.In this study, MR and CT imaging was collected from 55 prostate cancer patients treated on an MR linear accelerator. Read More

Cureus 2022 Apr 21;14(4):e24345. Epub 2022 Apr 21.

Department of Radiology, Brooke Army Medical Center, San Antonio, USA.

Paraphimosis is a urologic emergency that requires prompt diagnosis to avoid potential morbidity. Diagnosis is made clinically and imaging findings have not been described. We will present the case of an 84-year-old man with a history of metastatic prostate cancer and prior pelvic external beam radiation therapy who presented to the emergency department with urinary retention. Read More

Cureus 2022 Apr 19;14(4):e24283. Epub 2022 Apr 19.

Internal Medicine, Hospital Prof. Doutor Fernando Fonseca, Amadora, PRT.

Treatment-emergent transformed neuroendocrine prostate cancer (NEPC) is a highly aggressive type of prostate cancer that may arise from typical adenocarcinoma of the prostate, which is associated with rapidly progressive disease involving visceral sites and refractoriness to hormonal therapy. We present the case of a 74-year old male with a known history of stable prostate adenocarcinoma treated with transurethral prostate resection, local radiotherapy (RT), and androgen deprivation therapy (ADT) in 2020 who presented to the emergency room with complaints of shoulder and anterior chest pain, dyspnoea, and fatigue. Upon examination, a solid, adherent breast mass and infra-clavicular adenopathy were palpable. Read More

Front Oncol 2022 5;12:832508. Epub 2022 May 5.

Department of Counseling Psychology, Social Psychology, and Counseling, College of Health, Ball State University, Muncie, IN, United States.

Background: Equitable cancer survivorship care for gay and bisexual male (GBM) prostate cancer survivors should be responsive to their sexual health needs. Rates of sexually transmitted infections (STIs) are higher among GBM compared to heterosexual men across the lifespan. In addition, evidence suggests that GBM will use a variety of strategies to cope with sexual dysfunction that may increase risk for STIs. Read More