8,546 results match your criteria Penile Cancer


Demographic disparities of penile cancer in Appalachian Kentucky.

Can J Urol 2021 Jun;28(3):10713-10718

Department of Urology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.

Introduction: Appalachian Kentucky is a region characterized by poor healthcare literacy and access. We investigate the disparities in demographic distribution and outcomes of penile squamous cell carcinoma (pSCC) in rural Kentucky.

Materials And Methods: Data were retrieved for patients with pSCC from 1995-2015 from the Kentucky Cancer Registry and the Surveillance, Epidemiology and End Results Program (SEER) and were used to investigate differences between Appalachian Kentucky and the remainder of the state and country. Read More

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First case of acrometastases to the wrist reported from penile cancer.

J Cancer Res Ther 2021 Apr-Jun;17(2):599-601

Department of Electroradiology, Medical University; Department of Medical Physics, Greater Poland Cancer Centre, Poznan, Poland.

Penile cancer is a rarely diagnosed cancer that affects 0.4%-0.6% of all male population. Read More

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Development of Incidence and Surgical Treatment of Penile Cancer in Germany from 2006 to 2016: Potential Implications for Future Management.

Ann Surg Oncol 2021 Jun 12. Epub 2021 Jun 12.

Department of Urology, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany.

Background: Penile cancer is a rare disease and surgical treatment often entails a significant impact on quality of life. The aim of this study was to analyze trends in surgical treatment patterns in Germany.

Methods: We analyzed data from the nationwide German hospital billing database and the German cancer registry from 2006 to 2016. Read More

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Mandatory HPV Vaccination; Opportunity to Save Lives, Improve Readiness and Cut Costs.

Mil Med 2021 Jun 12. Epub 2021 Jun 12.

Department of Obstetrics and Gynecology, Brooke Army Medical Center, Joint Base San Antonio, TX 78234, USA.

Human papillomavirus (HPV) is the most common sexually transmitted infection (STI) in the U.S. military and accounts for more healthcare visits than the next two most common STIs combined. Read More

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The role of primary inguinal surgical debulking for locally advanced penile cancer followed by reconstruction with myocutaneous flap.

Int Braz J Urol 2021 Jun 10;47. Epub 2021 Jun 10.

Serviço de Urologia, Hospital Municipal Souza Aguiar, Rio de Janeiro, RJ, Brasil.

Purpose: To evaluate surgical complications and oncological outcomes of patients submitted to primary radical inguinal surgical debulking (PRISD) and myocutaneous pediculate flap reconstruction (MPFR) for locally advanced penile cancer (PC).

Materials And Methods: Forty-two patients with ulcerated and/or fixed bulky inguinal masses underwent unilateral or bilateral PRISD with MPFR. Tensor fascia lata flap (TFL) was the standard of care for all patients. Read More

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Use of flaps in inguinal lymphadenectomy in metastatic penile cancer.

Int Braz J Urol 2021 Jun 10;47. Epub 2021 Jun 10.

Unidade de Pesquisa Urogenital, Universidade do Estado do Rio de Janeiro - UERJ, Rio de Janeiro, RJ, Brasil.

Purpose: Reviewing surgical procedures using fasciocutaneous and myocutaneous flaps for inguinal reconstruction after lymphadenectomy in metastatic penile cancer.

Material And Methods: We reviewed the current literature of the Pubmed database according to PRISMA guidelines. The search terms used were "advanced penile cancer", "groin reconstruction", and "inguinal reconstruction", both alone and in combination. Read More

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Living in a rural area as a risk factor for worst outcomes in penile cancer.

Int Braz J Urol 2021 Jun 15;47. Epub 2021 Jun 15.

UROGIV Research Group, School of Medicine, Universidad del Valle, Cali, Colombia.

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The entry inhibitor DS003 (BMS-599793), a BMS-806 analogue, provides superior activity as a pre-exposure prophylaxis candidate.

AIDS 2021 Jun 7. Epub 2021 Jun 7.

Centre for Infection, Division of Cellular & Molecular Medicine, St George's University of London, UK. Current address: Section of Infectious Diseases, Faculty of Medicine, St Mary's Campus, Imperial College, UK. Centre for Infection, Division of Cellular & Molecular Medicine, St George's University of London, UK. Current address: London School of Hygiene and Tropical Medicine, London, UK Section of Infectious Diseases, Faculty of Medicine, St Mary's Campus, Imperial College, UK. Current address: Amsterdam UMC, Netherlands Department of Surgery and Cancer, St Mary's Hospital, Imperial College London, UK Centre for Infection, Division of Cellular & Molecular Medicine, St George's University of London, UK. Current address: Janssen Vaccines & Prevention B.V. Leiden, Netherlands International Partnership for Microbicides, Silver Spring, MD, USA.

Objective: Small molecule inhibitors able to bind to gp120 and prevent CD4-induced HIV-1 envelope conformational change provide an important class of inhibitors. Currently, only Fostemsavir is approved for HAART, which makes this class of inhibitors attractive candidates for prevention. We assessed the activity of DS003 (BMS-599793), an analogue of BMS-378806, in different mucosal tissues and elucidated its mechanism of action. Read More

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A rare case report of femoral neck metastasis secondary from penile carcinoma and literature review.

Urol Case Rep 2021 Sep 25;38:101692. Epub 2021 Apr 25.

Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ZheJiang Province, China.

Metastatic bone diseases are common in the advanced stage of numerous cancers, but rarely reported to be secondary from penile cancer. To date, there are only 9 cases of skeletal metastasis from penile cancer reported in literature worldwide. Herein, we report a rare case of the femoral neck metastasis secondary from penile carcinoma in a 35-year-old Chinese male. Read More

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September 2021

A cross-sectional cadaveric study of the correlation between genital organ measurements, serum testosterone, and serum prostate-specific antigen levels in Japanese male subjects.

Int J Physiol Pathophysiol Pharmacol 2021 15;13(2):36-42. Epub 2021 Apr 15.

Department of Urology, Graduate School of Medicine, The University of Tokyo 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-8655, Japan.

Association of organ sizes in the genitalia have long been a topic of interest for the general public. However, factors such as selection bias, embarrassment, and invasive testing have hindered studies on living individuals. We obtained measurements of penile size, testicular weight, and prostate weight, and conducted related serum testing on 63 Japanese male adults who died of unexpected reasons and underwent autopsy from 2009 to 2013. Read More

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Recovery of health-related quality of life in patients undergoing robotic radical cystectomy with intracorporeal diversion.

BJU Int 2021 Jun 5. Epub 2021 Jun 5.

Department of Urology, University College London Hospitals NHS Foundation Trust, London, UK.

Background: To report the health-related quality of life (HRQoL) after robotic assisted radical cystectomy and intracorporeal urinary diversion (iRARC) and to identify factors impacting on return to baseline.

Patients And Methods: Consecutive patients undergoing iRARC between January 2016 - December 2017 completed the EORTC-QLQ-C30 and EORTC-QLQ-BLM30 questionnaires before surgery and had a minimum of 12 months follow-up postoperatively.

Results: A total of 76 patients met the inclusion criteria at 12 months. Read More

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Ten-year treatment complication outcomes of radical prostatectomy vs external beam radiation vs brachytherapy for 1503 patients with intermediate risk prostate cancer.

Brachytherapy 2021 Jun 2. Epub 2021 Jun 2.

Department of Research and Evaluation, Kaiser Permanente, Pasadena, CA.

Purpose: To compare 10-year late complications of radical prostatectomy (RP) versus external-beam-radiation-therapy (EBRT) versus brachytherapy (BT).

Methods: Retrospective analysis was performed on 1503 intermediate-risk-prostate-cancer patients treated from 2004 to 2007, using univariate comparisons. Eight hundred and nineteen underwent RP, 574 EBRT, and 110 BT. Read More

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Assessment of PI3K/mTOR/AKT Pathway Elements to Serve as Biomarkers and Therapeutic Targets in Penile Cancer.

Cancers (Basel) 2021 May 12;13(10). Epub 2021 May 12.

Department of Urology and Pediatric Urology, University Medicine Mainz, 55122 Mainz, Germany.

The PI3K/mTOR/AKT pathway might represent an intriguing option for treatment of penile cancer (PeCa). We aimed to assess whether members of this pathway might serve as biomarkers and targets for systemic therapy. Tissue of primary cancer from treatment-naïve PeCa patients was used for tissue microarray analysis. Read More

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Case Report: F-PSMA PET/CT May Improve the Clinical Management of Penile Metastases From Prostate Cancer.

Front Oncol 2021 13;11:683343. Epub 2021 May 13.

Department of Urology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Metastases from prostate cancer (PCa) to the penis are extremely rare, and few case reports exist in the literature. Because most patients usually present with multiple distant metastases at diagnosis, the prognosis is very poor. With the wide application of prostate-specific membrane antigen (PSMA) PET/CT, penile metastases may be detected at an early stage. Read More

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What Is New in the Pathologic Staging of Penile Carcinoma in the 8th Edition of AJCC TNM Model: Rationale for Changes With Practical Stage-by-stage Category Diagnostic Considerations.

Adv Anat Pathol 2021 Jul;28(4):209-227

Instituto de Patología e Investigación, Asunción.

For >50 years the tumor, node, metastasis (TNM) classification model of malignant tumors has been the main resource for clinicians, pathologists, radiologists and public health professionals ensuring a homogeneous classification and patients' management based on common staging and prognosis factors. Penile cancer was first included for staging in the third edition of the TNM classification with several changes in the last version, the 8th edition of the AJCC TNM Manual, in 2017. Some changes in the pT category were done due to recent knowledge regarding the prognostic importance of anatomical level of invasion, vascular and perineural invasion and tumor grading. Read More

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A Massive Penile Tumor.

Urology 2021 May 25. Epub 2021 May 25.

USC Institute of Urology, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California. Electronic address:

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Prevalence of Human Papillomavirus (HPV) DNA among Men with Oropharyngeal and Anogenital Cancers: A Systematic Review and Meta-Analysis.

Asian Pac J Cancer Prev 2021 May 1;22(5):1351-1364. Epub 2021 May 1.

Manipal Institute of Virology, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Objective: The term ''Human Papillomavirus'' or ''HPV'' has become synonymous with uterine cervical cancer leading to feminisation of all the preventive measures, especially immunisation. Taking into consideration the rising number of HPV associated cancers among men in many developed countries and the risk of transmission to women, male HPV infection is a serious concern. A systematic review and meta-analysis of literature was performed to determine the global prevalence of HPV among men with oropharyngeal and anogenital cancers. Read More

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Prevalence of human papillomavirus in young men who have sex with men after the implementation of gender-neutral HPV vaccination: a repeated cross-sectional study.

Lancet Infect Dis 2021 May 24. Epub 2021 May 24.

Melbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia; Central Clinical School, Monash University, Melbourne, VIC, Australia.

Background: Anal infection with high-risk human papillomavirus (HPV) genotypes 16 and 18 and anal cancer are overrepresented in men who have sex with men (MSM). This study investigated HPV prevalence in young MSM before and after the implementation of a school-based quadrivalent HPV (genotypes 6, 11, 16, and 18) vaccination programme for boys in Australia in 2013.

Methods: In this repeated cross-sectional study, MSM aged 16-20 years were recruited from two successive birth cohorts via sexual health clinics and the community in Melbourne, Australia. Read More

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Penile granulomas after BCG instillations. A case report and review of literature.

Urol Case Rep 2021 Sep 16;38:101716. Epub 2021 May 16.

Pathology Anatomy, Spain.

Penile granulomas has been rarely reported in the setting of BCG instillations. We present a 70 year-old male with multiple penile granulomas during BCG instillations due a high-grade urothelial bladder cancer. Histopathological study revealed granulomatous structures with central necrosis as seen after BCG therapy. Read More

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September 2021

Incidence of HPV-related anogenital intraepithelial neoplasia and cancer in men with diabetes compared with the general population.

Epidemiology 2021 May 20. Epub 2021 May 20.

Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark Statistics and Data Analysis, Danish Cancer Society Research Center, Copenhagen, Denmark Steno Diabetes Center Copenhagen, Copenhagen, Denmark University of Southern Denmark, Odense, Denmark Department of Gynecology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Introduction: Diabetes may increase risk of human papillomavirus (HPV)-related precancer and cancer. We estimated incidence of penile and anal high-grade intraepithelial neoplasia (hgPeIN, hgAIN) and squamous cell carcinoma (SCC) in men with diabetes compared with the entire Danish male population without diabetes.

Materials And Methods: In this registry-based cohort study, we included all men born 1916-2001 and residing in Denmark (n=2,528,756). Read More

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Isolated penile metastases secondary to invasive bladder cancer.

BMJ Case Rep 2021 05 25;14(5). Epub 2021 May 25.

Urology, Yorkshire and the Humber Postgraduate Deanery, York, UK.

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Penile cancer in Ireland - A national review.

Surgeon 2021 May 22. Epub 2021 May 22.

Department of Urology, Mercy University Hospital, Co. Cork, Ireland.

Objective: Penile cancer is a rare malignancy, with a reported incidence of 1.5/100,000 males in the Republic of Ireland in 2015. The aim of this study was to perform the first national review and to evaluate clinicopathological factors affecting survival. Read More

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Patterns of Recurrence Following Inguinal Lymph Node Dissection for Penile Cancer: Optimizing Surveillance Strategies.

J Urol 2021 May 25:101097JU0000000000001790. Epub 2021 May 25.

H Lee Moffitt Cancer Center, Department of Genitourinary Oncology, Tampa, Florida.

Purpose: Our primary objective is to detail the incidence, site, and timing of pSCC recurrence after ILND.

Methods: Retrospective analysis of 551 patients who underwent ILND for pSCC, from 2000 to 2017. The primary outcome was pSCC recurrence after ILND. Read More

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A systematic review and meta-analysis of the prevalence of human papillomavirus infection in Indigenous populations - A Global Picture.

J Oral Pathol Med 2021 May 18. Epub 2021 May 18.

Australian Research Centre for Population Oral Health, Adelaide Dental School, University of Adelaide, Adelaide, Australia.

Background And Aim: Recent trends have shown a decline in the rates of Human Papillomavirus (HPV) associated cervical cancer in the vaccinated population but there has been a spike in the HPV associated oropharyngeal, anal and penile cancers in the majority of the unvaccinated population which are young and middle aged males. Indigenous populations at an international level carry a disproportionate burden of most diseases. The aim of this meta-analysis was to ascertain the worldwide prevalence of HPV infection in Indigenous populations stratified by sex and site and to document the most commonly reported HPV types. Read More

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High-dose-rate brachytherapy with surface applicator in penile cancer.

Brachytherapy 2021 May 13. Epub 2021 May 13.

Radiation Oncology, Department of Surgical and Biomedical Science, University of Perugia and Perugia General Hospital, Perugia, Italy.

Purpose: An alternative to surgery for penile cancer is radiation therapy which is administered with external beam techniques and/or brachytherapy (BT) either interstitial or using a surface applicator. Here we report our experience in penile cancer patients treated with high-dose-rate (HDR)-BT with the surface technique, analyzing dosimetric parameters and clinical outcomes.

Methods And Materials: Between June 2016 and December 2019, 7 patients with squamous cell carcinoma of the penis received HDR-BT by means of customized applicators that were constructed using a 3D printer or thermoplastic mask. Read More

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Treatment Options and Outcomes for Men with Penile Intraepithelial Neoplasia: A Systematic Review.

Eur Urol Focus 2021 May 11. Epub 2021 May 11.

Department of Urology, The Christie NHS Foundation Trust, Manchester, UK; Luzerner Kantonsspital, Luzern, Switzerland. Electronic address:

Penile intraepithelial neoplasia (PeIN) is a rare skin condition with potential to progress to invasive penile cancer. We performed a systematic review of treatment options and outcomes for PeIN. Topical agents showed response and recurrence rates of 40-100% and 20% for imiquimod, and 48-74% and 11% for 5-fluorouracil, respectively. Read More

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c-MET receptor-targeted fluorescence on the road to image-guided surgery in penile squamous cell carcinoma patients.

J Nucl Med 2021 May 14. Epub 2021 May 14.

the Netherlands Cancer Institute, Netherlands.

In penile squamous cell carcinoma (pSCC), primary surgery aims to obtain oncologically safe margins while minimizing mutilation. Surgical guidance provided by receptor-specific tracers could potentially improve margin detection and reduce unnecessary excision of healthy tissue. Here, we present the first results of a prospective feasibility study for real-time intraoperative visualization of pSCC using a fluorescent mesenchymal-epithelial transition factor (c-MET) receptor targeting tracer (EMI-137). Read More

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COVID-19 Endothelial Dysfunction Can Cause Erectile Dysfunction: Histopathological, Immunohistochemical, and Ultrastructural Study of the Human Penis.

World J Mens Health 2021 May 7. Epub 2021 May 7.

Department of Urology, University of Miami Miller School of Medicine, Miami, FL, USA.

Purpose: A pilot study to describe histopathological features of penile tissue of patients who recovered from symptomatic COVID-19 infection and subsequently developed severe erectile dysfunction (ED).

Materials And Methods: Penile tissue was collected from patients undergoing surgery for penile prosthesis for severe ED. Specimens were obtained from two men with a history of COVID-19 infection and two men with no history of infection. Read More

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Prevalence of genital human papillomavirus by age and race/ ethnicity among males.

Clin Infect Dis 2021 May 13. Epub 2021 May 13.

Center for Interdisciplinary Research in Women's Health, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, TX, USA.

Background: Genital and oral cancers are often caused by human papillomavirus (HPV) types that can be prevented through HPV vaccination. Since HPV is sexually transmitted, knowledge of penile prevalence of vaccine-type HPV among US males can help predict potential disparities in these cancers. This study examines penile HPV prevalence by age and race/ethnicity among males. Read More

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The role of circumcision, tobacco, and alcohol use in genital human papillomavirus infection among men from Denmark.

Int J STD AIDS 2021 May 12:9564624211014727. Epub 2021 May 12.

Unit of Virus, Lifestyle and Genes, 165143Danish Cancer Society Research Center, Copenhagen, Denmark.

It is crucial to understand the natural history of genital human papillomavirus (HPV) infection in men to prevent the increasing male HPV-related disease burden. We evaluated the associations between HPV infection and circumcision, smoking, and alcohol use after accounting for sexual behavior. The study included 2331 male personnel from Danish barracks. Read More

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