8,171 results match your criteria Penile Cancer


Risk of erectile dysfunction after modern radiotherapy for intact prostate cancer.

Prostate Cancer Prostatic Dis 2020 Jul 9. Epub 2020 Jul 9.

Duke Cancer Institute, Durham, NC, USA.

Background: Erectile dysfunction (ED) is a prevalent side effect of prostate cancer treatment. We hypothesized that the previously reported rates of ED may have improved with the advent of modern technology. The purpose of this project was to evaluate modern external beam radiotherapy and brachytherapy techniques to determine the incidence of radiotherapy (RT) induced ED. Read More

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http://dx.doi.org/10.1038/s41391-020-0247-xDOI Listing

Two Cases of Human Papillomavirus-Related Oropharyngeal Cancer After the Treatment of Cervical Cancer.

Authors:
Tomoko Yamazaki

Cureus 2020 Jun 4;12(6):e8434. Epub 2020 Jun 4.

Head and Neck Cancer: Medical Oncology, Miyagi Cancer Center, Natori, JPN.

Recently, the incidence of human papillomavirus (HPV)-related head and neck cancers (oropharynx and oral) has increased rapidly. Secondary HPV-related cancers after an initial index cancer at a site associated with an HPV infection have been reported, including invasive cervical, vaginal, vulval, anal, penile, and oropharyngeal cancer. Here, we describe two female oropharyngeal cancer patients who had been treated for secondary cervical cancers with chemoradiotherapy and achieved a good clinical response. Read More

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http://dx.doi.org/10.7759/cureus.8434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336687PMC

Immunophenotypes Based on the Tumor Immune Microenvironment Allow for Unsupervised Penile Cancer Patient Stratification.

Cancers (Basel) 2020 Jul 4;12(7). Epub 2020 Jul 4.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.

The tumor immune microenvironment (TIME) plays an important role in penile squamous cell carcinoma (peSCC) pathogenesis. Here, the immunophenotype of the TIME in peSCC was determined by integrating the expression patterns of immune checkpoints (programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1), cytotoxic T lymphocyte antigen 4 (CTLA-4), and Siglec-15) and the components of tumor-infiltrating lymphocytes, including CD8 or Granzyme B T cells, FOXP3 regulatory T cells, and CD68 or CD206 macrophages, in 178 patients. A high density of Granzyme B, FOXP3, CD68, CD206, PD-1, and CTLA-4 was associated with better disease-specific survival (DSS). Read More

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http://dx.doi.org/10.3390/cancers12071796DOI Listing

A Critical Analysis of Methodology Pitfalls in Duplex Doppler Ultrasound in the Evaluation of Patients With Erectile Dysfunction: Technical and Interpretation Deficiencies.

J Sex Med 2020 Jul 3. Epub 2020 Jul 3.

Sexual & Reproductive Medicine Program, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

Background: Penile duplex Doppler ultrasound (PDDU) is a minimally invasive tool to evaluate erectile hemodynamics in patients with erectile dysfunction (ED). Despite decades of use, there is still a large variability in PDDU protocols, and a high rate of false diagnosis is reported.

Aim: Review of PDDU methodology in the published literature addressing protocol heterogeneity, technical and interpretation challenges. Read More

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http://dx.doi.org/10.1016/j.jsxm.2020.05.023DOI Listing

Treatment of Urinary Incontinence in Patients With Erectile Dysfunction.

Sex Med Rev 2020 Jul 1. Epub 2020 Jul 1.

Professor, Department of Urology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.

Introduction: Concurrent urinary incontinence (UI) and erectile dysfunction (ED) can greatly damage a patient's quality of life. Owing to the intertwined anatomy, treatment options for one most certainly have implications on the other.

Objective: The aim of this review is to characterize and elucidate the treatment patients with postprostatectomy UI undergoing concurrent or subsequent treatment of ED. Read More

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http://dx.doi.org/10.1016/j.sxmr.2020.04.006DOI Listing

Activity and tolerability of maintenance avelumab immunotherapy after first line polychemotherapy including platinum in patients with locally advanced or metastatic squamous cell penile carcinoma: PULSE.

Bull Cancer 2020 Jun;107(5S):eS16-eS21

Oncologie médicale, Centre Hospitalier Universitaire, Besançon, 25030 Besançon cedex, France; / Medical Oncology, University Hospital, Besançon, France; INSERM, UMR1098, Besançon, France.

Background Metastatic Squamous cell Penile Carcinoma (mSCPC) is an orphan disease with a virally induced oncogenesis. PD-L1 expression rate is around 60% with a strong correlation between PD-L1 in the primary tumour and metastases. The first line systemic treatment relies on platinum-based chemotherapies with a median progression free survival and overall survival around 7. Read More

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http://dx.doi.org/10.1016/S0007-4551(20)30282-4DOI Listing

[Systemic treatment of locally advanced or metastatic penile cancer].

Bull Cancer 2020 Jun;107(5S):S17-S23

CHU de Besançon, oncologie, 25030 Besançon cedex, France; CHU de Besançon, oncologie, 25030 Besançon cedex, France; Inserm, UMR1098, 25020 Besançon cedex, France.

Penile cancers are rare, the vast majority is represented by squamous cell carcinoma, with HPV virus being found in 30 to 40% of cases. At a locally advanced or metastatic stage, first-line treatment relies on platinum and taxane based polychemotherapy. The prognosis for advanced or metastatic penile cancer remains poor, with overall survival ranging from 13. Read More

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http://dx.doi.org/10.1016/S0007-4551(20)30274-5DOI Listing

Conditional Survival after Surgery for Patients with Penile Cancer.

Andrology 2020 Jul 3. Epub 2020 Jul 3.

Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: Penile cancer represents a rare pathology whose natural history of treatment is poorly understood.

Objective: To illustrate the dynamic survival profiles in surgically treated patients with squamous cell carcinoma of the penis (SCCP) using the conditional survival (CS) estimates.

Materials And Methods: Patients with non-metastatic SCCP were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Read More

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http://dx.doi.org/10.1111/andr.12856DOI Listing

Do Male University Students Know Enough About Human Papillomavirus (HPV) to Make Informed Decisions About Vaccination?

Med Sci Monit 2020 Jun 30;26:e924840. Epub 2020 Jun 30.

Department of Laboratorial Science and Technology and Vaccine Research Center, School of Public Health, Peking University, Beijing, China (mainland).

BACKGROUND The aim of this study was to evaluate the awareness of human papillomavirus (HPV), knowledge of HPV-associated diseases, as well as willingness to undergo HPV vaccination among male university students in China, especially factors influencing vaccination willingness. MATERIAL AND METHODS We conducted a cross-sectional study among university students in Beijing, Tianjin, and Hebei, China by using a convenience sampling method. We assessed a) the awareness of HPV, b) knowledge of HPV-associated diseases, c) willingness to undergo HPV vaccination, and d) sexual behaviors among male university students. Read More

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http://dx.doi.org/10.12659/MSM.924840DOI Listing

Immune-Related Adverse Events Mimicking Behcet's Disease in a Gastric Cancer Patient Following Camrelizumab Treatment.

Iran J Immunol 2020 Jun;17(2):167-171

Department of Surgery,The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China.

Background: Anti-programmed cell death 1(anti-PD-1) antibodies are immune checkpoint inhibitors (ICIs) used as a treatment option for a number of cancers to expand lifespan. However, the toxicity caused by ICIs is often unpredictable and can be occasionally life-threatening.

Objective: To evaluate the immune-related adverse events (irAEs) induced by Camrelizumab, an anti-PD-1 antibody in a patient with gastric cancer. Read More

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http://dx.doi.org/10.22034/iji.2020.85507.1717DOI Listing

Incidence, cost and gender differences of oropharyngeal and noncervical anogenital cancers in South Korea.

BMC Public Health 2020 Jun 29;20(1):1035. Epub 2020 Jun 29.

College of Pharmacy, Ewha Womans University, Seoul, South Korea.

Background: Human papillomavirus (HPV) is associated with a significant public health burden, yet few studies have been conducted in Asia, especially on noncervical cancers. We estimated the incidence and cost of oropharyngeal and noncervical anogenital (anal, vulvar, vaginal, penile) cancer in Korea.

Methods: We conducted a retrospective cohort study using Korea's National Health Insurance (NHI) claim database from 2013 to 2016. Read More

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http://dx.doi.org/10.1186/s12889-020-09161-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325282PMC

Penile verrucous squamous cell carcinoma: A rare case report.

Arch Ital Urol Androl 2020 Jun 23;92(2). Epub 2020 Jun 23.

Haydarpasa Numune Training and Research Hospital, University of Health Sciences, Department of Urology, Uskudar/Istanbul.

Penile cancer is a rare type of urological cancer. Predisposing factors include phimosis, poor hygiene, and smoking. Circumcision in early childhood has been shown to be protective against penile cancer. Read More

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http://dx.doi.org/10.4081/aiua.2020.2.114DOI Listing

A Review of Factors Affecting Patient Satisfaction With Inflatable Penile Prosthesis.

Sex Med Rev 2020 Jun 21. Epub 2020 Jun 21.

University of Texas McGovern Medical School and MD Anderson Cancer Center, Division of Urology, Houston, TX, USA. Electronic address:

Introduction: A variety of factors that can influence patient satisfaction after inflatable penile prosthesis (IPP) surgery, including patient expectations before surgery, intraoperative complications, and perceived penile shortening and partner satisfaction after surgery. While patient satisfaction rates with IPP are high, there are several reported methods to further improve patient satisfaction with IPP.

Objective: Identifying factors responsible for patient satisfaction after IPP surgery from preoperative counseling, intraoperative techniques, and postoperative care and identifying ways to improve overall patient satisfaction. Read More

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http://dx.doi.org/10.1016/j.sxmr.2020.04.001DOI Listing

Evaluating the Impact of Penile Girth Discrepancy on Patient Bother in Men With Peyronie's Disease: An Observational Study.

J Sex Med 2020 Jun 20. Epub 2020 Jun 20.

Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

Background: Men with Peyronie's disease (PD) may experience penile narrowing. Little data on penile girth changes and their psychosocial impact exist.

Aim: To assess girth discrepancy in men with PD and its association with patient bother. Read More

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http://dx.doi.org/10.1016/j.jsxm.2020.05.003DOI Listing

A rare case of penile metastases from small cell prostate cancer.

Rev Int Androl 2020 Jun 20. Epub 2020 Jun 20.

Urology Department, Hospital Universitario Sanitas La Moraleja, Universidad Francisco de Vitoria, Madrid, Spain.

We present a case of an 83-year-old-male with painless penile nodules several months after he was diagnosed with pure prostatic small cell carcinoma. Penile doppler ultrasound and magnetic resonance imaging demonstrated solid nodules in both corpora cavernosa. Fine-needle aspiration of the nodules with immunohistochemical examination confirmed prostatic small cell carcinoma origin of metastases. Read More

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http://dx.doi.org/10.1016/j.androl.2019.11.003DOI Listing

What you need to know: updates in penile cancer staging.

World J Urol 2020 Jun 22. Epub 2020 Jun 22.

Department of Genito-Urinary Oncology and Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, USA.

Purpose: We sought to discuss the updates in the 8th edition (8E) of The American Joint Committee on Cancer (AJCC) staging for penile cancer and to provide relevant evidence associated with the major changes that occurred.

Methods: A comprehensive search of PubMed and Web of Science was performed for relevant English language articles from 2004 through 2019. Literature resulting from this search were reviewed and articles pertinent to penile cancer staging changes were included. Read More

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http://dx.doi.org/10.1007/s00345-020-03302-zDOI Listing

Sentinel lymph node biopsy using indocyanine green in penile cancer.

Nat Rev Urol 2020 Jun 22. Epub 2020 Jun 22.

Institute of Andrology, University College London Hospitals NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1038/s41585-020-0347-3DOI Listing
June 2020
4.840 Impact Factor

Therapeutic and Surgical Indications for Patients with Penile Cancer in the COVID-19 era.

Int Braz J Urol 2020 Jul;46(suppl.1):86-92

Hospital de Jerez de la Frontera, Cádiz, Spain.

Purpose: The aim of this work is to review and synthesize the existing evidence and recommendations regarding to the therapeutic and surgical indications as well as monitoring of patients with Penile Cancer in COVID-19 era and to propose an action protocol to facilitate decision-making.

Material And Methods: A non-systematic review of the literature regarding the management of penile cancer during the COVID-19 pandemic was performed until April 30, 2020. We propose our recommendations based on this evidence. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2020.S110DOI Listing

RhoA/ROCK pathway inhibitor ameliorates erectile dysfunction induced by radiation therapy in rats.

Radiother Oncol 2020 Jun 19;150:174-180. Epub 2020 Jun 19.

Division of Translational Radiation Sciences (DTRS), Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, USA.

Objectives: Prostate cancer (PCa) treatment with radiation therapy (RT) has an excellent cure rate. However, Radiation-induced Erectile Dysfunction (RiED) is a common and irreversible toxicity impacting quality of life, and there is no FDA approved specific drug for RiED. We previously showed that prostate RT increased RhoA/ROCK signaling in the cavernous nerve (CN) and penile tissues, which may lead to RiED in rats. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.06.021DOI Listing

Prostatic irradiation-induced sexual dysfunction: A review and multidisciplinary guide to management in the radical radiotherapy era (Part II on Urological Management).

Rep Pract Oncol Radiother 2020 Jul-Aug;25(4):619-624. Epub 2020 May 6.

Sexual and Reproductive Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.

Prostate cancer is the most common malignancy in men and the second leading cause of cancer-related death in men. Radiotherapy is a curative option that is administered via external beam radiation, brachytherapy, or in combination. Sexual dysfunction is a common toxicity following radiotherapy, similar to men undergoing radical prostatectomy, but the etiology is different. Read More

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http://dx.doi.org/10.1016/j.rpor.2020.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286930PMC

[Andrology and penile cancer. Recommendations during COVID-19 pandemia.]

Arch Esp Urol 2020 Jun;73(5):395-404

Servicio de Urología. Hospital Puerta de Hierro. Lyx Instituto de Urología. Universidad Francisco de Vitoria. Madrid. España.

Purpose: The COVID-19 pandemic which has affected Spain since the beginning of 2020 compels us to determine recomendations for the practice of Andrology in present times.

Materials And Methods: A web search is carried out in English and Spanish and a joint proposal is defined by experts in Andrology from different regions of Spain.

Results: Most diagnostic and therapeutic procedures in Andrology can be safey postponed during the COVID-19 pandemic. Read More

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Establishment, Characterization, and Imaging of a First Platinum-resistant Penile Cancer Patient-derived Xenograft in Nude Mice: A eUROGEN Project.

Eur Urol 2020 Jun 11. Epub 2020 Jun 11.

Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven, Department of Urology, University Hospitals Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2020.05.033DOI Listing

Restoration of the Lost Obscured Coronal Sulcus: A Novel Surgical Technique for Penile Lichen Sclerosus with Severe Preputial Adhesions.

Eur Urol 2020 Jun 11. Epub 2020 Jun 11.

University College London Hospital, London, UK; Royal Berkshire Hospital, Reading, UK. Electronic address:

Background: Lichen sclerosus (LS) may cause the glans and prepuce to become fused, making a standard circumcision impossible. Most authorities recommend excision of the fused area with glans resurfacing, although partial circumcision is often performed.

Objective: To evaluate an alternative technique that preserves the fused area and allows a complete circumcision without grafting. Read More

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http://dx.doi.org/10.1016/j.eururo.2020.04.040DOI Listing

Penile Implant Infection: Experience With Expanded Salvage Criteria and a Shortened Course of Postoperative Antibiotics.

Sex Med 2020 Jun 9. Epub 2020 Jun 9.

Division of Urologic Surgery, Department of Surgery, Duke University School of Medicine, Durham, NC, USA 27701.

Introduction: The preferred treatment for inflatable penile prosthesis (IPP) infection includes antibiotic therapy, device removal, and immediate replacement. While this is an accepted procedure, the delivery and length of postoperative antibiotics are not standardized. Furthermore, historical salvage criteria may be overly restrictive given the new salvage techniques. Read More

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http://dx.doi.org/10.1016/j.esxm.2020.04.007DOI Listing

Ano-uro-genital mucosal melanoma UK national guidelines.

Eur J Cancer 2020 Jun 9;135:22-30. Epub 2020 Jun 9.

The Royal Marsden NHS Foundation Trust, UK. Electronic address:

Ano-uro-genital (AUG) mucosal melanomas are rare cancers associated with poor outcomes and limited evidence-based management. The United Kingdom AUG mucosal melanoma guideline development group used an evidence-based systematic approach to make recommendations regarding the diagnosis, treatment and surveillance of patients diagnosed with AUG mucosal melanomas. The guidelines were sent for international peer review, and are accredited by The National Institute for Health and Clinical Excellence (NICE). Read More

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http://dx.doi.org/10.1016/j.ejca.2020.04.030DOI Listing

CD4 trajectory models and onset of non-AIDS defining anal genital warts, pre-cancer, and cancer in PLWH.

Sex Transm Dis 2020 Jun 10. Epub 2020 Jun 10.

Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35242.

Background: It is unclear how the characteristics of CD4 counts predict non-AIDS defining (NAD) HPV-related ano-genital warts (AGW) and anal high-grade squamous intraepithelial lesions/cancer (HSIL) in PLWH. We compared the associations between 3 CD4 counts measures and these disease outcomes in the study.

Methods: Retrospective socio-behavioral and clinical data from electronic health records of 4,803 PLWH from 2006-2018 were included. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001215DOI Listing

Cavernosal Metastasis From Prostate Cancer on 18F-Fluciclovine PET/CT.

Authors:
Ba D Nguyen

Clin Nucl Med 2020 Jun 8. Epub 2020 Jun 8.

From the Department of Radiology, Mayo Clinic, Scottsdale, AZ.

Uncommon penile metastasis from prostate cancer has been reported on PET/CT imaging with F-FDG, F-fluorocholine, C-choline, and Ga-PSMA. The author presents an additional case of F-fluciclovine PET/CT depiction of proximal and distal cavernosal metastases from prostate cancer with corresponding contrast-enhanced CT findings. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003116DOI Listing

A Multicenter Investigation Examining AUA-Recommended Antibiotic Prophylaxis vs. Non-standard Prophylaxis in Preventing Device Infections in Penile Prosthesis Surgery in Diabetic Patients.

J Urol 2020 Jun 10:101097JU0000000000001158. Epub 2020 Jun 10.

Department of Urology, University of California, Irvine Medical Center, Orange, California.

Purpose: American Urological Association (AUA) antibiotic prophylaxis recommendations may be insufficient for covering organisms commonly found in penile prosthesis infections. The purpose of this study was to assess the difference between AUA-recommended antibiotic prophylaxis and non-standard prophylaxis in preventing device infections in penile prosthesis surgery performed in diabetics.

Materials And Methods: A multicenter, retrospective cohort study of diabetic patients undergoing primary penile prosthesis surgery was performed between April 2003 and August 2018. Read More

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http://dx.doi.org/10.1097/JU.0000000000001158DOI Listing

Nomogram prediction of overall survival based on log odds of positive lymph nodes for patients with penile squamous cell carcinoma.

Cancer Med 2020 Jun 10. Epub 2020 Jun 10.

Drug Clinical Trial Agency, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.

Purpose: This study aimed to establish a nomogram to predict the long-term overall survival (OS) for patients with penile squamous cell carcinoma (PSCC).

Method: The PSCC patients receiving regional lymph node dissection (RLND) were enrolled from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2015. The dataset of all eligible patients were used to develop the predictive model. Read More

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http://dx.doi.org/10.1002/cam4.3232DOI Listing

Recent advances in understanding and managing Lichen Sclerosus.

F1000Res 2020 15;9. Epub 2020 May 15.

Division of Surgery, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.

Lichen sclerosus (LS), or balanitis xerotica obliterans as it was previously known, is a chronic inflammatory lymphocyte-mediated scarring dermatosis that often affects the preputial skin and glans, leading to phimosis and urethral strictures if left untreated. We present a narrative review of the literature assessing its aetiology and pathogenesis and discuss its links to penile cancer and its medical and surgical management. Possible hypotheses for the development of LS include chronic exposure to trapped urine, leading to changes in the epithelial structure. Read More

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http://dx.doi.org/10.12688/f1000research.21529.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233179PMC

Penile carcinoma and HPV infection (Review).

Exp Ther Med 2020 Jul 11;20(1):91-96. Epub 2019 Nov 11.

Urology Department, Emergency University Central Military Hospital, 010825 Bucharest, Romania.

Penile carcinoma is a relatively frequent health issue in the developing countries such as Africa, Asia and South America, usually affecting men aged between 50 and 70 years. It is a highly treatable disease in its early stages, but has serious physical and psychological consequences. Usually, penile carcinoma is located in the penile glans, in approximately half the cases, with the most frequent histological type being squamous cell carcinoma with its microscopic subtypes. Read More

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http://dx.doi.org/10.3892/etm.2019.8181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273896PMC

IL-23 Expression in Stewart-Treves Syndrome: Two Case Reports and Immunohistochemical Investigation.

Case Rep Oncol 2020 Jan-Apr;13(1):462-467. Epub 2020 Apr 30.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Stewart-Treves syndrome (STS) is a rare cutaneous lymphangiosarcoma developing from chronic lymph edema as a consequence of radical mastectomy or surgical invasion of the groin for the treatment of cervical or penile cancer. Previous reports suggested possible mechanisms in the development of lymphangiosarcoma that correlate with the immunological background of STS patients. In this report, we described two cases of STS developing in patients who underwent radical dissection for cervical cancer, we employed immunohistochemical staining of IL-23 and IL-17. Read More

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http://dx.doi.org/10.1159/000506975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250377PMC

Anterior resection of the rectum vs radical prostatectomy. Are there any differences in sexual rehabilitation?

Rev Col Bras Cir 2020 29;47:e20202469. Epub 2020 May 29.

Portuguese Institute of Oncology, Lisboa, Portugal.

Purpose: The aim of this study was to evaluate the impact of penile rehabilitation in restoring erectile function in patients submitted to anterior resection of the rectum (ARR) or radical prostatectomy (RP), comparing the results between these two groups.

Materials And Methods: We performed a unicenter retrospective cohort study, on patients evaluated in our multidisciplinary oncosexology consultation, between January 2015 and January 2018, submitted to RP or ARR (males) and presenting sexual dysfunction. We evaluate the patient and oncologic characteristics, the type of sexual dysfunction, marital status, assessed the International Index of Erectile Function (IIEF-5) on the first and last consultation and the therapeutic approach. Read More

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http://dx.doi.org/10.1590/0100-6991e-20202469DOI Listing

Penile cancer with visceral metastasis and p16/human papillomavirus positivity: An unusual case of long-term survival.

Urol Case Rep 2020 Nov 24;33:101278. Epub 2020 May 24.

Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Squamous cell carcinoma (SCC) of the penis is a rare cancer in the industrialized countries, including the United States. Risk factors for these cancers include inflammatory conditions as well as infection with the human papilloma virus (HPV). Treatment modalities are based on TNM staging and may include surgical management or chemoradiation. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260682PMC
November 2020

HPV16 induces penile intraepithelial neoplasia and squamous cell carcinoma in transgenic mice: first mouse model for HPV-related penile cancer.

J Pathol 2020 Jun 3. Epub 2020 Jun 3.

CITAB, Universidade de Trás-os-Montes e Alto Douro, UTAD, Vila Real, Portugal.

Penile cancer is an under-studied disease that occurs more commonly in developing countries and 30-50% of cases show high-risk human papillomavirus (HPV) infection. Therapeutic advances are slow, largely due to the absence of animal models for translational research. Here, we report the first mouse model for HPV-related penile cancer. Read More

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http://dx.doi.org/10.1002/path.5475DOI Listing
June 2020
7.429 Impact Factor

Cancer attributable to human papillomavirus infection in China: Burden and trends.

Cancer 2020 Jun 2. Epub 2020 Jun 2.

School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China.

Background: Human papillomavirus (HPV) is associated with a substantial percentage of cervical cancer, and a significant percentage of anal, penile, vaginal, vulvar, oral cavity, oropharyngeal, and laryngeal cancers. Understanding the burden and trends of HPV-attributable cancers is crucial to HPV prevention strategies. In the current study, the authors estimated the latest burden and trends of HPV-attributable cancers in China. Read More

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http://dx.doi.org/10.1002/cncr.32986DOI Listing

Radiation therapy in the management of the inguinal region in penile cancer: What's the evidence?

Urol Oncol 2020 May 29. Epub 2020 May 29.

Department of Radiation Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL. Electronic address:

Due to its rarity and lack of prospective studies, clinical evidence for the management of the inguinal lymphatic nodal basin with radiation therapy in penile cancer (PeCa) has been limited. In this report, we review the current literature and further investigated the landscape of radiation sensitivity in nodal metastases of PeCa utilizing our well-established genome-based radiosensitivity index (RSI) platform. We hypothesized that optimal therapeutic gain could be achieved in PeCa stratified by the combination of clinicopathological parameters, genomic heterogeneity, and RSI-based radiation dose prescription (RxRSI). Read More

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http://dx.doi.org/10.1016/j.urolonc.2020.05.004DOI Listing
May 2020
2.768 Impact Factor

Incidentally detected cavernous hemangioma of the glans penis after circumcision: A case report.

Medicine (Baltimore) 2020 May;99(21):e20217

Rationale: Hemangiomas of the glans penis are very rare. Treatment options include surgical excision, laser therapy, intralesional sclerotherapy, electrofulguration, and cryotherapy. However, there have been no definitive treatment guidelines established to date. Read More

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http://dx.doi.org/10.1097/MD.0000000000020217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249958PMC

How does Diabetes Impair Penile Tissues during Erectile Dysfunction?

Endocr Metab Immune Disord Drug Targets 2020 May 31. Epub 2020 May 31.

Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630. China.

Background: Erectile dysfunction (ED) is a significant but underestimated complication during diabetes mellitus (DM). Currently, few special treatments are available in clinic due to the lack of specific therapeutic targets. Genomic analysis can be helpful to find potential targets. Read More

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http://dx.doi.org/10.2174/1871530320666200531140735DOI Listing

Prognostic value of systemic inflammatory factors NLR, LMR, PLR and LDH in penile cancer.

BMC Urol 2020 May 27;20(1):57. Epub 2020 May 27.

Department of Urology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, 650118, Yunnan, China.

Background: Penile squamous cell carcinoma (PSCC) represents an important public health problem for developing countries. The major prognostic factors in PSCC are pathological subtype, perineural invasion, lymphovascular invasion, depth of invasion and grade, which are hard to obtain precisely before the operation. Besides, micro-metastases will be detected in about 30% of intermediate-risk patients with clinically non-palpable inguinal lymph nodes after inguinal lymph node dissection (ILND). Read More

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http://dx.doi.org/10.1186/s12894-020-00628-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251912PMC
May 2020
1.937 Impact Factor

Cost-effectiveness analysis of a gender-neutral human papillomavirus vaccination program in the Netherlands.

Vaccine 2020 Jun 23;38(30):4687-4694. Epub 2020 May 23.

Department of Health Sciences, University of Groningen, University Medical Center, Hanzeplein 1, 9713 GZ Groningen, the Netherlands; Unit of Pharmacotherapy, Epidemiology & Economics, University of Groningen, Groningen Research Institute of Pharmacy, A Deusinglaan 1, 9713 AV Groningen, the Netherlands; Department of Economics, Econometrics & Finance, University of Groningen, Faculty of Economics & Business, P.O. Box 800, 9700 AV Groningen, the Netherlands. Electronic address:

Background: Vaccinating girls against human papillomavirus (HPV) infection is a highly effective and cost-effective intervention to provide protection against HPV-induced cancers. Since vaccination coverage rates among girls is modest in the Netherlands, additional strategies should be implemented to improve the protection against HPV-related cancer. Here we assessed the benefits and cost-effectiveness of gender-neutral vaccination. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.05.031DOI Listing

Prostate penile metastasis: Incidence and imaging pattern on Ga-PSMA PET/CT.

J Med Imaging Radiat Oncol 2020 May 25. Epub 2020 May 25.

Wesley Medical Imaging, The Wesley Hospital, Auchenflower, Queensland, Australia.

Background: Prostate cancer commonly metastasises to bone and regional lymphatics and more rarely to locations such as the brain, skin and penis. Gallium-68 prostate-specific membrane antigen ( Ga-PSMA) positron emission tomography/computed tomography (PET/CT) has widely become the routine imaging modality for prostate cancer staging and re-staging in Australia. The aim of this study was to retrospectively review all Ga-PSMA PET/CT examinations performed to date at our institution to determine the frequency of penile metastases. Read More

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http://dx.doi.org/10.1111/1754-9485.13052DOI Listing

Uro-oncology in times of COVID-19: The available evidence and recommendations in the Indian scenario.

Indian J Cancer 2020 Apr-Jun;57(2):129-138

Department of Urology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

The Corona Virus Disease-2019 (COVID-19), one of the most devastating pandemics ever, has left thousands of cancer patients to their fate. The future course of this pandemic is still an enigma, but health care services are expected to resume soon in a phased manner. This might be a long drawn process and we need to have policies in place, to be able to fight both, the SARS-CoV-2 virus and cancer, simultaneously, and emerge triumphant. Read More

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http://dx.doi.org/10.4103/ijc.IJC_356_20DOI Listing

Human papillomavirus 16-positive penile Bowen's disease involving the distal urethra: A case report.

SAGE Open Med Case Rep 2020 13;8:2050313X20918985. Epub 2020 May 13.

Department of Integrative Cancer Therapy and Urology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

A 79-year-old man visited our hospital with a chief complaint of erythema around the urethral orifice of the glans, and a diagnosis of penile Bowen's disease was made by penile skin biopsy. Initially, local tumor resection with skin grafting from the femoral skin was performed. However, histopathological examination revealed a positive urethral margin of tumor. Read More

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http://dx.doi.org/10.1177/2050313X20918985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223195PMC

Clinical outcomes of glansectomy with split-thickness skin graft reconstruction for localized penile cancer.

Can Urol Assoc J 2020 May 12. Epub 2020 May 12.

Division of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada.

Introduction: Penectomy as the traditional surgical treatment of penile cancer, has substantial adverse functional and psychological impact. Glansectomy with split thickness skin graft (STSG) reconstruction aims to provide curative resection while maximizing functional outcomes, and minimizing psychological harm. We describe our outcomes of glansectomy with STSG reconstruction for penile cancer in a Canadian setting. Read More

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http://dx.doi.org/10.5489/cuaj.6277DOI Listing

Scrotal and Penile Erythrodysesthesia Associated with Neoadjuvant Capecitabine Chemoradiation.

Cureus 2020 Apr 18;12(4):e7724. Epub 2020 Apr 18.

Department of Radiation Oncology, Swedish Cancer Institute, Seattle, USA.

Capecitabine, a prodrug of fluorouracil, is a component of many chemotherapy regimens used to treat a wide variety of malignancies. One of the most common adverse reactions experienced by those who have been exposed to capecitabine is palmar-plantar erythrodysesthesia (PPE). PPE is a cutaneous manifestation of chemotherapy-related drug toxicity that has signs and symptoms of erythema, edema, pain, ulceration, or desquamation of the palms of the hands and soles of the feet. Read More

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http://dx.doi.org/10.7759/cureus.7724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234053PMC

Prevalence of human papillomavirus and implication on survival in Chinese penile cancer.

Virchows Arch 2020 May 19. Epub 2020 May 19.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China.

We assessed the prevalence of HPV DNA in a large series of Chinese penile cancer and examine its association with the histological subtype, p16 expression, and prognosis. We pathologically categorized 226 invasive penile squamous cell carcinomas and assessed HPV genotyping by real-time PCR and p16 immunohistochemistry. The results were correlated with histopathological and clinical parameters and disease-specific survival (DSS). Read More

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http://dx.doi.org/10.1007/s00428-020-02831-7DOI Listing

Nomograms to predict the presence and extent of inguinal lymph node metastasis in penile cancer patients with clinically positive lymph nodes.

Transl Androl Urol 2020 Apr;9(2):621-628

Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Background: We developed two nomograms to predict the presence of inguinal lymph node metastasis (ILNM) and two or more histologically positive inguinal lymph nodes (ILNs) or one ILN with extranodal extension (ENE) in penile cancer patients with clinically positive inguinal lymph nodes (ILNs).

Methods: This study enrolled 75 penile squamous cell carcinoma (PSCC) patients with clinically positive ILNs. A binary logistic regression model was taken to screen out the risk factors for the presence of ILNM and two or more positive ILNs or one node with ENE in one side. Read More

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http://dx.doi.org/10.21037/tau.2020.01.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215016PMC

Pelvic Floor Muscle Training and Erectile Dysfunction in Radical Prostatectomy: A Randomized Controlled Trial Investigating a Non-Invasive Addition to Penile Rehabilitation.

Sex Med 2020 May 14. Epub 2020 May 14.

School of Human Sciences (Exercise and Sport Science), The University of Western Australia, Crawley, Western Australia.

Introduction: Pelvic floor muscle (PFM) training for postprostatectomy incontinence is considered a first line approach to rehabilitation, but PFM training for erectile dysfunction (ED) after surgery is less well known. With more than 1.4 million new cases diagnosed globally per year, there is a need for non-invasive options to assist sexual dysfunction recovery. Read More

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http://dx.doi.org/10.1016/j.esxm.2020.03.005DOI Listing

Risks from Deferring Treatment for Genitourinary Cancers: A Collaborative Review to Aid Triage and Management During the COVID-19 Pandemic.

Eur Urol 2020 Jul 3;78(1):29-42. Epub 2020 May 3.

Department of Surgery, Division of Urology, Augusta University-Medical College of Georgia, Augusta, GA, USA; Georgia Cancer Center, Augusta, GA, USA. Electronic address:

Context: The coronavirus disease 2019 (COVID-19) pandemic is leading to delays in the treatment of many urologic cancers.

Objective: To provide a contemporary picture of the risks from delayed treatment for urologic cancers to assist with triage.

Evidence Acquisition: A collaborative review using literature published as of April 2, 2020. Read More

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http://dx.doi.org/10.1016/j.eururo.2020.04.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196384PMC