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Asian J Androl 2018 Nov 30. Epub 2018 Nov 30.

EngenderHealth, Nairobi 00100, Kenya.

To assess safety of the no-flip ShangRing male circumcision technique and to determine clinical course and safety of spontaneous detachment (i.e., allowing the device to fall off), we conducted a case series of no-flip ShangRing circumcision combined with a randomized controlled trial of removal 7 days postcircumcision versus spontaneous detachment at two health facilities in Kenya. Read More

Ir Med J 2018 06 7;111(6):772. Epub 2018 Jun 7.

Department of Urological Surgery, Tallaght Hospital, Dublin 24

We present the case of an 83-year-old man with Extramammary Paget’s disease (EMPD) of the penis. He underwent a total penectomy and histopathology confirms the association of underlying invasive high grade urothelial carcinoma. Penile EMPD is rare and can be misinterpreted for benign skin conditions. Read More

Urol J 2018 Dec 6. Epub 2018 Dec 6.

Department of Pediatric Surgery, Selcuk University Medical Faculty, Konya,Turkey.

Purpose: Hypospadias is a congenital anomaly that includes defi-cient ventral structure of the penis. Proximal hypospadias cases make up 20% of all hypospadias cases. The choice of operative technique for hypospadias repair depends on the severity, and it is influenced by the surgeon's experience and perception of where priorities should lie. Read More

J Cancer 2018 20;9(22):4234-4241. Epub 2018 Oct 20.

Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.

Squamous cell carcinoma of the penis is a rare but often aggressive disease. A large proportion of penile cancers are associated with HPV infection, mainly with HPV high-risk subtypes 16 and 18. From other HPV-related malignancies a link between a functional SNP in the p53 gene (rs1042522, p. Read More

Sex Transm Infect 2018 Dec 5. Epub 2018 Dec 5.

Institute of Tropical Medicine, Antwerp, Belgium.

Objectives: Bacterial vaginosis (BV) increases women's susceptibility to sexually transmitted infections (STIs) and HIV and may partly explain the high incidence of STI/HIV among girls and young women in East and southern Africa. The objectives of this study were to investigate the association between BV and sexual debut, to investigate other potential risk factors of BV and to estimate associations between BV and STIs.

Methods: Secondary school girls in Mwanza, aged 17 and 18 years, were invited to join a cross-sectional study. Read More

Int J Urol 2018 Dec 3. Epub 2018 Dec 3.

Department of Urology, University Medical Center Utrecht, Utrecht, the Netherlands.

Objective: To determine the incidence of penile intraepithelial neoplasia in the Netherlands using a nationwide histopathology registry and to discuss the nomenclature of premalignant penile lesions.

Methods: Data from patients in the Netherlands diagnosed with a premalignant penile lesion between January 1998 and December 2007 were collected from the nationwide histopathology registry (PALGA); this database covers all pathology reports of inhabitants in the Netherlands. The premalignant lesions included were erythroplasia of Queyrat; Bowen's disease; bowenoid papulosis; mild, moderate and severe dysplasia; and carcinoma in situ of the penis. Read More

Curr Opin Endocrinol Diabetes Obes 2018 Nov 30. Epub 2018 Nov 30.

Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.

Purpose Of Review: Genitoplasty in children with disorders of sex development (DSD) is an ethically complex issue. From a surgical perspective, genitoplasty in early childhood is preferred because it is felt to be associated with improved tissue healing, decreased risk of complications, and reduced psychological impact of genital surgery. However, advocacy groups and recent ethics literature have argued for deferring genitoplasty until a child reaches decisional maturity. Read More

Int Urol Nephrol 2018 Dec 1. Epub 2018 Dec 1.

Department of Urology, School of Medicine, Gazi University, Ankara, Turkey.

Transl Androl Urol 2018 Dec;7(6):960-967

Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.

Infections are among the most feared and devastating complications of penile prosthesis infections, often requiring surgical exploration and explantation are prosthesis infections. While the rate of infections have decreased due to antibiotic prophylaxis, antiseptic device preparation, increased sterility in implantation techniques and device modifications, infections still occur at a rate of 1-3%. This article reviews the formation of biofilms on penile prostheses and novel, experimental methods to prevent and eradicate them. Read More

Transl Androl Urol 2018 Dec;7(6):935-940

Department of Urology, Mayo Clinic, Rochester, MN, USA.

Background: Limited data are available on how partners of men with Peyronie's disease (PD) are affected by the disease. We sought to characterize PD patients whose curvatures result in pain for their partners during penetrative intercourse.

Methods: We queried a database of all men undergoing initial evaluation for PD at a single clinic between March 2014 and June 2016. Read More

Urol Case Rep 2019 Mar 23;23:25-26. Epub 2018 Nov 23.

University of Melbourne, Department of Surgery, Austin Hospital, Melbourne, Victoria, Australia.

Primary transitional cell carcinoma arising from the anterior portion of the male urethra is rare, with no recent cases reported in the literature. We present a case of penile TCC with positive urine cytology and a delayed definitive diagnosis. Read More

Urol Case Rep 2019 Mar 9;23:3-5. Epub 2018 Nov 9.

Fox Chase Cancer Center, Temple University Health System, 333 Cottman Ave, Philadelphia, PA 19111, United States.

Indian J Plast Surg 2018 May-Aug;51(2):155-166

Department of Plastic Reconstructive and Faciomaxillary Surgery, Madras Medical College, Chennai, Tamil Nadu, India.

Introduction: The feeling of incongruence between phenotypic sex and psychological recognition of self-gender is termed gender dysphoria. Transsexualism is the most extreme form of this disorder.

Aims And Objectives: The aims and objectives of the study are to evaluate the esthetic and functional outcome of embryonic equivalents-based male-to-female sex reassignment surgery in transwomen using the institutional scoring system. Read More

Sex Med Rev 2018 Nov 29. Epub 2018 Nov 29.

Department of Urology and Pediatric Urology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.

Introduction: Peyronie's disease (PD) is a fibrotic disorder that leads to plaque formation in ∼3-9% of adult men. Connective tissue buildup results in plaque formation, penile curvature and shortening, and in some cases, pain. In the active phase of PD, penile pain is a common symptom, often accompanied by progression in curvature. Read More

Sex Med Rev 2018 Nov 29. Epub 2018 Nov 29.

Florida Hospital Tampa Urology, Tampa, FL, USA. Electronic address:

Background: Penile prosthesis for erectile restoration remains the only surgical option for medical refractory erectile dysfunction. Many expert prosthetic surgeons recommend special care when placing a reservoir in a patient who has undergone prior radical pelvic surgery (PRPS) due to distortion of anatomy and obliteration of the dead space in the traditionally used space of Retzius.

Aim: Review all the current literature on penile prosthesis implantation in patients with prior pelvic surgery, with an emphasis on tips and tricks for reservoir placement in this unique population. Read More

Sex Med Rev 2018 Nov 29. Epub 2018 Nov 29.

Division of Urologic Surgery, Duke University, Durham, USA.

Introduction: Penile prosthesis (PP) implantation is associated with high patient satisfaction and improved sexual quality of life (SQoL). The SQoL benefits of PP implantation are generalizable across subpopulations of PP implant patients, but the literature is heterogeneous in design and largely without instruments to specifically measure SQoL changes due to PP, requiring extrapolation from less granular measures.

Aim: To provide a comprehensive review of available literature regarding SQoL with a penile prosthesis. Read More

Sex Med 2018 Nov 29. Epub 2018 Nov 29.

Laboratory for Experimental Urology, Organ Systems, Department of Development and Regeneration, University of Leuven, Leuven, Belgium.

Introduction: Previous studies have shown that the injection of adipose tissue-derived stem cells (ADSCs) into the tunica albuginea (TA) during the active phase of Peyronie's disease (PD) prevents the development of fibrosis.

Aim: To investigate, using an animal model, whether local injection of human ADSCs (hADSCs) can alter the degree of fibrosis in the chronic phase of PD.

Methods: 27 male, 12-week-old rats were divided into 3 equal groups: sham, PD without treatment, and PD treated with hADSCs 1 month after disease induction. Read More

Sex Med Rev 2018 Nov 28. Epub 2018 Nov 28.

Department of Urology, Tulane University, New Orleans, LA, USA. Electronic address:

Background: Priapism has been linked to many commonly prescribed medications, as well as recreational drugs and toxins. Although the incidence of priapism as a result of medication is small, the increasing use of antidepressants, antipsychotics, and recreational drugs may lead to more cases of pharmacologically-induced priapism in the future.

Aim: To provide a comprehensive, up-to-date review of the most common causes of pharmacologically induced priapism and discuss incidence, pathophysiology, and basic management strategies. Read More

J Am Acad Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Center for Clinical Studies, Houston, TX, USA; Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA.

In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Read More

Urol Int 2018 Dec 5:1-14. Epub 2018 Dec 5.

Heart Valve Disease Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Introduction: The use of pericardium has been expanded into different surgical modalities; however, there are scarce data regarding the feasibility of the pericardium in reconstructive urologic surgeries. We systematically reviewed the literature on the effectiveness of the pericardial tissue for reconstructive urologic surgeries.

Materials And Methods: PubMed and Scopus were searched online for evidence on the use of the pericardium in urologic surgeries. Read More

Int Urol Nephrol 2018 Dec 4. Epub 2018 Dec 4.

Department of Urology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey.

Purpose: This study aimed to demonstrate the effects of oxytocin on penile tissues in ischemia-reperfusion injury developed after priapism.

Methods: Forty Wistar Albino strain male rats were divided into four groups. The control group (n = 10) was not intervened. Read More

J Int Med Res 2018 Dec 5:300060518813506. Epub 2018 Dec 5.

1 Department of Urology, Cantonal Hospital Aarau, Aarau, Switzerland.

This case report describes a unique manifestation of a primary urethral squamous cell carcinoma (SCC) as the underlying pathology in an 80-year-old male patient who underwent partial penectomy due to an enlarging penile mass. Persistent pain in the right knee was discovered to be a pathologic fracture using magnetic resonance imaging. Computed tomography-guided biopsy confirmed metastatic SCC. Read More

Rev Prat 2017 Jun;67(6):628-631

Service d'urologieandrologie, CHU Carémeau, Nîmes, France.

Lapeyronie's disease. Lapeyronie's disease is a common condition responsible for an acquired penile curvature due to a fibrous albugineal plaque, affecting 3.4 to 9% of the male population. Read More

Rev Prat 2017 Jun;67(6):623-627

Service d'urologieandrologie, CHU Carémeau, Nîmes, France.

Cosmetic surgery of the penis. There is no consensus on the size below which it is justifiable to accept or attempt to modify the size of the penis. Length of the penis under 10 cm in erection can be considered as an acceptable limit, in a patient who suffers from it. Read More

Rev Prat 2017 Jun;67(6):616-622

Département d'urologie, CHU de Toulouse, Toulouse, France.

News in erectile dysfunction. Erectile dysfunction (ED) is the most commonly treated sexual disorder affecting up to 20% of all men. As ED adversely affects the lives of millions of men, the public health implications of this condition are significant and represent a challenge for our healthcare system. Read More

Plast Reconstr Surg 2018 Nov;142(5):729e-733e

Ghent, Belgium; and Madison, Wis. From the Department of Plastic and Reconstructive Surgery, University of Ghent; and the Department of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health.

Gender dysphoria, the incongruence between anatomical sex and gender identity, is estimated to affect 1 percent of the population. Creation of a feminine vulva with labia minora remains a technical challenge for surgeons, especially in circumcised patients. The authors present the technique developed by the senior author (S. Read More

Plast Reconstr Surg 2018 Nov;142(5):1320-1326

New York, N.Y. From the Hansjörg Wyss Department of Plastic Surgery, and the Division of Medical Ethics, New York University Langone Medical Center.

Technical success has been achieved in several forms of vascularized composite allotransplantation, including hand, face, penis, and lower extremity. However, the risks of lifelong immunosuppression have limited these procedures to a select group of patients for whom nontransplant alternatives have resulted in unsatisfactory outcomes. Recent reports of facial allograft failure, and subsequent reconstruction using autologous tissues, have reinforced the idea that a surgical contingency plan must be in place in case this devastating complication occurs. Read More

Urol Case Rep 2019 Jan 25;22:57-59. Epub 2018 Oct 25.

Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, United Kingdom.

J Sex Med 2018 Nov 30. Epub 2018 Nov 30.

Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA. Electronic address:

Background: Erectile dysfunction (ED) caused by pelvic neurovascular injury (PNVI) is often refractory to treatment. In many cases, erectogenic therapy is administered in a delayed fashion.

Aim: To evaluate penile hemodynamic effects and histologic changes associated with delayed low-intensity extracorporeal shock wave therapy (Li-ESWT) after PNVI ED in a rat model. Read More

J Sex Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address:

J Sex Med 2018 Nov 30. Epub 2018 Nov 30.

Division of Urology, Virginia Commonwealth University Medical Center, West Hospital, Richmond, VA, USA; Division of Urology, Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA.

Background: Despite the known nephrotoxicity of gentamicin, in 2008 the American Urological Association recommended a weight-based gentamicin dose of 5 mg/kg for antimicrobial prophylaxis during urologic prosthetic surgery.

Aim: To identify and characterize rates of acute kidney injury (AKI) in urologic prosthetic surgery, both before and after the implementation of weight-based gentamicin dosing.

Methods: We performed a single-institution retrospective study of patients receiving perioperative gentamicin during implant, revision, salvage, or explant of inflatable penile prostheses, malleable penile prostheses, or artificial urinary sphincters between the years 2000 and 2017. Read More

BJU Int 2018 Nov 30. Epub 2018 Nov 30.

Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, 27101, USA.

Objective: To determine the long-term therapeutic effect among three types of human cell types on erectile function recovery in a rodent model of dual neurovascular injured erectile dysfunction (NVED).

Materials And Methods: A dual NVED model was established in athymic rats by crushing the bilateral cavernous nerves and ligations of the bilateral internal pudendal nerve-vessel bundles. At the time of defect creation, three different types of human cell populations (2. Read More

Biomed Res Int 2018 25;2018:6452965. Epub 2018 Oct 25.

Department of Physiology, Faculty of Medicine, Khon Kaen University, 40002, Thailand.

In this study, we aimed to assess the effect and possible underlying mechanism of leaves extract on male sexual behaviors in stress-exposed rats. Male Wistar rats were orally given extract at doses of 25, 100, and 200 mg/kg BW before 12-hour-immobilization exposure for 14 days. Sexual behaviors, serum testosterone and corticosterone levels, TH-positive cells density in nucleus accumbens (NAc) and ventral tegmental area (VTA), MAO-B activity in NAc and medial preoptic area (MPOA), testis histology together with phosphodiesterase type-5 ( PDE-5) activity, and endothelial nitric oxide synthase (eNOS) expression in penis were evaluated after treatment. Read More

Visc Med 2018 Oct 31;34(5):389-392. Epub 2018 Jul 31.

Clinic of Internal Diseases, Family Medicine and Oncology, Faculty of Medicine, Vilnius University, National Cancer Institute, Vilnius, Lithuania.

Background: Metastasis of rectal cancer to the penis is a very rare condition with less than 40 cases found in the literature.

Case Report: We here report a case of a 41-year-old man who was diagnosed with rectal cancer which later metastasized to the penis. The patient was treated with neoadjuvant radiotherapy, underwent rectal resection, had adjuvant chemotherapy, and, despite that, had penile metastasis 2 years later. Read More

Case Rep Urol 2018 25;2018:9798607. Epub 2018 Oct 25.

West Virginia University Department of Urology, USA.

Fournier's gangrene isolated to the penis is exceedingly rare. It is an urologic emergency that requires emergent parenteral antibiotics as well as aggressive irrigation and debridement. While human bite wounds can be overlooked as a serious cause of injury and infection, they can result in highly dangerous, polymicrobial infections in affected patients. Read More

Lond Med Phys J 1827 Sep;3(15):201-204

St. George's Hospital.

Lond Med Phys J 1827 Sep;3(15):197-199

St. Thomas's Hospital.

Med Phys J 1810 Jun;23(136):441-447

Urology 2018 Nov 26. Epub 2018 Nov 26.

Dept of Pathology, PGIMER, Chandigarh.

Turk J Urol 2018 Sep 1;44(5):437-440. Epub 2018 Sep 1.

Department of General Surgery, Post Graduate Institute of Medical Education And Research (PGIMER), Chandigarh, India.

We present a 15 year old boy with multiple vesicular lesions involving the scrotum and penile skin which developed following circumcision. Surgical excision of the penoscrotal skin with local flap cover was done. Histopathology was consistent with lymphangioma circumscriptum. Read More

J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.

Department of Urology, China-Japan Union Hospital of Jilin University, Changchun, China.

Introduction: Erectile dysfunction (ED) is a common sexual problem for men and the exploration of its treatment is still in mire demand. We aim to investigate the role of the Toll-like receptor 4 (TLR4)/myeloid differentiation primary response gene 88 (MyD88) signaling pathway in the pathogenesis of angiotensin II (Ang-II) induced ED.

Methods: Male Sprague-Dawlay rats were treated with Ang-II and intracavernous pressure (ICP) was measured to confirm the occurrence of ED. Read More

JAMA Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pathology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain.

An Bras Dermatol 2018 Nov/Dec;93(6):881-883

Department of Dermatopathology, Hospital Santa Casa de Misericórdia de Vitória, Vitória (ES), Brasil.

Zoon's plasma cell balanitis is a chronic genital inflammatory dermatosis that affects uncircumcised men, especially the elderly. It's characterized by painless erythematous plaques of orange hue, located on the glans penis and foreskin. Circumcision is the most effective treatment; however, it can be hard for patients to accept. Read More

Br J Cancer 2018 Nov 28. Epub 2018 Nov 28.

MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, 90 High Holborn, London, UK.

Background: High-risk human papilloma viruses (HPV) are a causative agent of anogenital and oropharyngeal cancers. Patients treated for a preinvasive or invasive HPV-associated cancer may be at increased risk of a second such malignancy.

Methods: We performed a systematic review and random effects meta-analysis to estimate the risk of HPV-associated cancer after prior diagnosis. Read More

J Pediatr Urol 2018 Sep 19. Epub 2018 Sep 19.

Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Blvd. 82, DK-8200 Aarhus N, Denmark; Department of Urology, Section of Paediatric Urology, Aarhus University Hospital, Palle Juul-Jensens Blvd. 99, DK-8200 Aarhus N, Denmark.

Purpose: The ventral aspect of the penis in boys with hypospadias is composed of dysplastic tissue of the skin and the urethra. The aim of this study was to assess the pre-operative size and biomechanical properties of urethrae in boys with and without hypospadias using a more objective catheter-based system.

Materials & Methods: In this non-blinded clinical observation study, the study population consisted of 19 boys with hypospadias-the case group (median age 13. Read More

J Med Imaging Radiat Sci 2018 Mar 11;49(1):76-83. Epub 2017 Nov 11.

Division of Radiation Oncology, London Regional Cancer Program, London Health Sciences Centre, London, Ontario, Canada; Department of Physics and Astronomy, University of Western Ontario, London, Ontario, Canada.

Purpose: High-precision radiotherapy relies on accurate anatomic localisation. Urethrography is often used to localise the prostatic apex. However, urethrography is an invasive localisation procedure and may introduce a systemic error. Read More

Int J Dermatol 2018 Nov 27. Epub 2018 Nov 27.

Department of Dermatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Int J Impot Res 2018 Nov 26. Epub 2018 Nov 26.

Department of Urology, Korea University College of Medicine, Seoul, Republic of Korea.

Despite the controversy regarding penile augmentation (PA), glans penis augmentation (GPA) is used in penile reconstructive surgery in selected patients with small glans penis. Since 2003, injectable hyaluronic acid (HA) gel has been used for GPA. The attractiveness of HA gel fillers and interest in this technique have led to the use of other fillers for GPA, particularly irreversible fillers that improve the longevity of HA gels. Read More

J Pediatr Urol 2018 Nov 3. Epub 2018 Nov 3.

Urology Training Program, Departments of Surgery and Pediatric Surgery, McGill University, Montreal, Canada. Electronic address: