7,721 results match your criteria Penile Cancer


Opportunities for use of radiation therapy in penile cancer based on patterns of care in the United States from 2007 to 2013.

Ther Adv Urol 2019 Jan-Dec;11:1756287219828972. Epub 2019 Feb 8.

Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, KS, USA.

Background: Radiation therapy (RT) is an effective modality for the treatment of squamous cell carcinomas of the penis. The National Comprehensive Cancer Network recommends consideration of primary radiation for penile preservation, in surgically unresectable tumors, and as adjuvant therapy for positive margins, bulky groin nodes or pelvic nodes. We performed a population-based analysis to evaluate the usage of RT in penile cancer from 2007 to 2013. Read More

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http://dx.doi.org/10.1177/1756287219828972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376511PMC
February 2019

Palmar-plantar Erythrodysesthesia with Genital Involvement Secondary to Capecitabine Chemoradiotherapy: A Case Report.

Cureus 2018 Dec 8;10(12):e3704. Epub 2018 Dec 8.

Radiation Oncology, London Regional Cancer Program, Western University, London, CAN.

Palmar-plantar erythrodysesthesia (PPE) is a common dermatologic adverse reaction secondary to capecitabine use, but the skin toxicity rarely involves the genitals. We describe a case of PPE with scrotal and penile involvement secondary to capecitabine chemotherapy concurrent with radiotherapy. The patient presented with pain and erythema involving the penis and scrotum during the fifth week of neoadjuvant chemoradiotherapy with capecitabine for T3c N2b M0 low rectal adenocarcinoma. Read More

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http://dx.doi.org/10.7759/cureus.3704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373891PMC
December 2018

Non-Infectious Reservoir-Related Complications During and After Penile Prosthesis Placement.

Sex Med Rev 2019 Feb 18. Epub 2019 Feb 18.

Division of Urology, University of Texas Health Science Center-McGovern Medical School at Houston, Department of Surgery, Houston, TX, USA; University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Introduction: Inflatable penile prosthesis (IPP) surgery offers a high satisfaction rate and low rate of complications when performed by experienced surgeons. However, reservoir placement, either in the space of Retzius (SOR), or alternative/ectopic locations, may lead to an array of serious complications that may require revision surgery.

Aim: To review the prevalence and management options for non-infectious intraoperative and postoperative complications related to prosthetic reservoirs. Read More

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http://dx.doi.org/10.1016/j.sxmr.2018.12.005DOI Listing
February 2019

Metastasis in penile corpus cavernosum from esophageal squamous carcinoma after curative resection: a case report.

BMC Cancer 2019 Feb 20;19(1):162. Epub 2019 Feb 20.

Department of Urology, Ningbo Urology & Nephrology Hospital, Ningbo, 315192, Zhejiang, China.

Background: Metastasis in penile corpus cavernosum from esophageal squamous carcinoma is a rare but fatal disease, which was reported in cases without series studies.

Case Presentation: An 84-year-old male smoker, who had a history of curative resection of esophageal squamous carcinoma 12 months before, presented with aggressive dysuria and penis pain for 1 month. Ultrasonic guided biopsy diagnosed metastatic squamous carcinoma from the primary in the esophagus. Read More

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http://dx.doi.org/10.1186/s12885-019-5356-3DOI Listing
February 2019

Treatment Options and Outcomes of Penile Constriction Devices.

Int Braz J Urol 2019 Feb 10;45. Epub 2019 Feb 10.

Hospital Municipal Souza Aguiar, Rio de Janeiro, RJ, Brasil.

Purpose: To study the effect of penile constriction devices used on a large series of patients who presented at our emergency facility. We explored treatment options to prevent a wide range of vascular and mechanical injuries occurring due to penile entrapment.

Materials And Methods: Between January 2001 and March 2016, 26 patients with penile entrapment were admitted to our facility and prospectively evaluated. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0667DOI Listing
February 2019

A Systematic Review of the Role of Penile Rehabilitation in Prostate Cancer Patients Receiving Radiotherapy and Androgen Deprivation Therapy.

J Med Imaging Radiat Sci 2019 Mar 26;50(1):171-178. Epub 2018 Oct 26.

Directorate of Radiotherapy, University of Liverpool, Liverpool, UK. Electronic address:

Introduction/background: Treatment-induced erectile dysfunction (ED) is a common side effect of radiotherapy and androgen deprivation therapy (ADT) that impacts on patient quality of life. Penile rehabilitation interventions including pharmacologic and physical therapies aim to reduce the impact of ED. Despite The National Institute for Health and Care Excellence guidelines recommending access to ED services, penile rehabilitation is not widely discussed or implemented. Read More

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http://dx.doi.org/10.1016/j.jmir.2018.09.004DOI Listing

A 3D-Printed Patient-Specific Phantom for External Beam Radiation Therapy of Prostate Cancer.

J Eng Sci Med Diagn Ther 2018 Nov 6;1(4). Epub 2018 Aug 6.

Department of Radiology, Boston Medical Center & Boston University School of Medicine, 820 Harrison Ave., Boston, MA 02118.

This paper presents the design evolution, fabrication, and testing of a novel patient and organ-specific, 3D printed phantom for external beam radiation therapy of prostate cancer. In contrast to those found in current practice, this phantom can be used to plan and validate treatment tailored to an individual patient. It contains a model of the prostate gland with a dominant intraprostatic lesion, seminal vesicles, urethra, ejaculatory duct, neurovascular bundles, rectal wall, and penile bulb generated from a series of combined T2-weighted/dynamic contrast-enhanced magnetic resonance images. Read More

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http://dx.doi.org/10.1115/1.4040817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376205PMC
November 2018

National Trends in Human Papillomavirus Awareness and Knowledge of Human Papillomavirus-Related Cancers.

Am J Prev Med 2019 Feb 14. Epub 2019 Feb 14.

Behavioral Research Program, National Cancer Institute, Bethesda, Maryland.

Introduction: The President's Cancer Panel released a report in 2014 calling for communication strategies to promote the human papillomavirus vaccine among males and females. The purpose of this study was to (1) estimate changes in human papillomavirus awareness and knowledge of human papillomavirus-related cancers from 2014 to 2017 using a nationally representative survey of adults in the U.S. Read More

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http://dx.doi.org/10.1016/j.amepre.2018.11.005DOI Listing
February 2019
1 Read

Trans-Fascial Placement of a High, Sub Muscular Reservoir in Patients Following Radical Cystectomy: Safety, Efficacy, and Predictability of Final Reservoir Location Verified With Abdominal Imaging.

J Sex Med 2019 Feb;16(2):338-345

Department of Urology, University of Miami Miller School of Medicine, Miami, FL, USA.

Introduction: With the increasing utilization of ectopic reservoir placement during multicomponent penile implant surgery, safety concerns have been raised about whether passing the reservoir through the floor of the inguinal canal consistently results in placement of the reservoir within the correct location.

Aim: To evaluate the safety, efficacy, and patient satisfaction associated with direct-vision, trans-fascial sub muscular reservoir placement in consecutive patients who had previously undergone radical cystectomy.

Methods: Perioperative data, complications, and follow up for the 12 cystectomy patients were evaluated using a comprehensive database of consecutive patients undergoing penile prosthesis placement at our center. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.12.015DOI Listing
February 2019
1 Read

High-Dose Rate Brachyther-apy in the Treatment of Early Stages of Penile Carcinoma.

Klin Onkol 2019 ;32(1):52-57

Background: Interstitial low dose rate brachyther-apy is established organ spar-ing treatment of T1- T2 penile carcinoma. Experience with high-dose rate brachyther-apy is limited in this indication.

Materials And Methods: Twenty-six patients with early penile carcinoma were treated by high-dose rate brachyther-apy at dose 18 × 3 Gy per fraction twice daily between 2002- 2018 at the Department of Oncology and Radiother-apy, University Hospital in Hradec Kralove. Read More

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http://dx.doi.org/10.14735/amko201952DOI Listing
January 2019

Malignant Tumors of the Penis - Dia-gnostics and Therapy.

Klin Onkol 2019 ;32(1):31-39

Background: Penile cancer belongs to group of relatively rare malignancies. It represents, on average, 0.5-1% of all tumours in males globally and occurs predominantly in older individuals (> 65 years). Read More

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http://dx.doi.org/10.14735/amko201931DOI Listing
January 2019
1 Read

Dose to the penile bulb and individual patient anatomy are predictive of erectile dysfunction in men treated with I low dose rate brachytherapy for localized prostate cancer.

Acta Oncol 2019 Feb 14:1-7. Epub 2019 Feb 14.

a Radiation Oncology Department , CHU , Brest , France.

Background: To evaluate the occurrence of erectile dysfunction at 3 years (3yED) after prostate brachytherapy (BT) and to predict 3yED after treatment based on patients and treatments characteristics.

Material And Methods: From September 2007 to July 2015, 117 men with mild or no ED [International Index of Erectile Function (IIEF-5) > 16] underwent Iodine real-time ultrasound-guided low-dose rate BT to a total dose of 160 Gy for low-risk or favorable intermediate-risk prostate adenocarcinoma, and were followed prospectively during 3 years. Median age was 63 years (51-79). Read More

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http://dx.doi.org/10.1080/0284186X.2019.1574981DOI Listing
February 2019

More lymph node dissection improves survival in patients with newly diagnosed lymph node-positive penile cancer.

Int Urol Nephrol 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, Shanghai Tenth People's Hospital, Tongji University, No. 301, Yanchang Road, Jing'an District, Shanghai, 200072, China.

Purpose: For patients with lymph node-positive (LN+) penile cancer, the optimal extent of lymph node dissection (LND) is currently not established. We aimed to reveal the potential association between survival and the number of LND in patients with newly diagnosed LN + penile cancer.

Methods: Patients with LN + penile cancer diagnosed between 2004 and 2015 were identified using the SEER database. Read More

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http://dx.doi.org/10.1007/s11255-019-02084-7DOI Listing
February 2019

Human Papillomavirus Risk Perceptions Among Young Adult Sexual Minority Cisgender Women and Nonbinary Individuals Assigned Female at Birth.

Perspect Sex Reprod Health 2019 Feb 12. Epub 2019 Feb 12.

Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston.

Context: Some sexual minority women may be less likely than other women to engage in human papillomavirus (HPV) prevention behaviors. Although risk perceptions have been found to be associated with health behaviors, HPV risk perceptions among U.S. Read More

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http://dx.doi.org/10.1363/psrh.12087DOI Listing
February 2019
1 Read

Postoperative vacuum therapy following AMS™ LGX 700® inflatable penile prosthesis placement: penile dimension outcomes and overall satisfaction.

Int J Impot Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Urology, Coral Gables Hospital, 3100 Douglas Rd, Coral Gables, FL, 33134, USA.

Penile shortening after inflatable penile prosthesis for erectile dysfunction is a common postoperative patient complaint and can reduce overall satisfaction with the procedure. In this prospective study we report our results regarding penile dimensions and patient satisfaction outcomes after 1 year of follow-up from AMS™LGX700® penile prosthesis implant with 6 months of vacuum erectile device therapy. Seventy-four selected patients with medically refractory erectile dysfunction underwent AMS™ LGX 700® IPP placement. Read More

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http://dx.doi.org/10.1038/s41443-019-0125-zDOI Listing
February 2019

Fertility preservation in male patients with cancer.

Authors:
Shlomi Barak

Best Pract Res Clin Obstet Gynaecol 2019 Feb 20;55:59-66. Epub 2018 Dec 20.

Assuta University Hospital, Ashdod, Israel; Division of Obstetrics and Gynecology, Ben-Gurion University of the Negev, Israel. Electronic address:

Advances in the treatment of cancer in young patients have led to great improvements in life expectancy, which currently approaches 80% 5-year survival rate. As a result, fertility preservation and desire for paternity have become a significant issue in this group. However, a major concern is the negative impact of chemotherapy, radiotherapy, and the malignancy itself on fertility. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2018.12.004DOI Listing
February 2019
1 Read

Important surgical concepts and techniques in inguinal lymph node dissection.

Curr Opin Urol 2019 Feb 5. Epub 2019 Feb 5.

Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida, USA.

Purpose Of Review: Penile cancer is a rare disease with significant physical and psychosocial morbidity. It has a propensity to spread to the inguinal lymph nodes where it can progress to the pelvis and beyond. Here, we present a contemporary review on the surgical management of the lymph nodes. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000591DOI Listing
February 2019
2.333 Impact Factor

The relationship between HPV and penile cancer: Filling a knowledge gap in the general population.

Can Urol Assoc J 2019 Feb;13(2):38

Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL, United States.

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http://dx.doi.org/10.5489/cuaj.5838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363573PMC
February 2019
1 Read

Optimized penile surface mold brachytherapy using latest stereolithography techniques: A single-institution experience.

Brachytherapy 2019 Feb 1. Epub 2019 Feb 1.

University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Electronic address:

Purpose: To describe a technique of penile surface mold high-dose-rate (HDR) brachytherapy and early outcomes.

Methods And Materials: Five patients diagnosed with a T1aN0 squamous cell carcinoma of the penis were treated using a penile surface mold HDR brachytherapy technique. A negative impression of the penis was obtained using dental alginate. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.01.002DOI Listing
February 2019
1.987 Impact Factor

Wide Variation in Opioid Prescribing After Urological Surgery in Tertiary Care Centers.

Mayo Clin Proc 2019 Feb;94(2):262-274

Department of Urology, Mayo Clinic, Rochester, MN. Electronic address:

Objective: To describe postoperative opioid prescribing practices in a large cohort of patients undergoing urological surgery.

Patients And Methods: We identified 11,829 patients who underwent 21 urological surgical procedures at 3 associated facilities from January 1, 2015, through December 31, 2016. After converting opioids to oral morphine equivalents (OMEs), prescribing patterns were compared within and across procedures. Read More

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http://dx.doi.org/10.1016/j.mayocp.2018.08.035DOI Listing
February 2019
1 Read

Incidence of external genital lesions related to human papillomavirus among Mexican men. A cohort study.

Salud Publica Mex 2018 Nov-Dic;60(6):633-644

Center for Infection Research in Cancer, Moffitt Cancer Center and Research Institute.Tampa, Florida.

Objective: To determine external genital lesion (EGL) incidence -condyloma and penile intraepithelial neoplasia (PeIN)- and genital HPV-genotype progression to these EGLs.

Materials And Methods: Participants (healthy males 18- 74y from Cuernavaca, Mexico, recruited 2005-2009, n=954) underwent a questionnaire, anogenital examination, and sample collection every six months;including excision biopsy on suspicious EGL with histological confirmation.Linear array assay PCR characterized 37 high/low-risk HPV-DNA types. Read More

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http://dx.doi.org/10.21149/8461DOI Listing
December 2016
2 Reads

Suprapubic Fat Pad Excision with Simultaneous Placement of Inflatable Penile Prosthesis.

J Sex Med 2019 Feb 26;16(2):333-337. Epub 2019 Jan 26.

University of South Florida, Department of Urology, Tampa, FL, USA. Electronic address:

Introduction: Many men suffering from erectile dysfunction are overweight with generous suprapubic fat pads, which often contribute to a decrease in visible exophytic phallic length.

Aim: To present a novel surgical concept of suprapubic fat pad excision with a concomitant placement of inflatable penile prosthesis.

Methods: A transverse incision begins slightly medial to the anterior superior iliac spine, with the superior edge crossing transversely to the contralateral anterior superior iliac spine. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.12.005DOI Listing
February 2019
1 Read

Penile Implant Considerations in the Bladder Cancer Survivor.

Curr Urol Rep 2019 Jan 28;20(2). Epub 2019 Jan 28.

Institute of Urology, USC/Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Suite 7416, Los Angeles, CA, 90089-9178, USA.

Purpose Of Review: After radical cystoprostatectomy, patients often develop erectile dysfunction refractory to first- and second-line treatments. In this review, we summarize and analyze the literature describing the technical considerations and outcomes of penile implant surgery in bladder cancer patients with history of radical cystectomy and urinary diversion.

Recent Findings: Penile prosthesis surgery in patients after radical cystectomy and urinary diversion has been infrequently described in the literature. Read More

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http://dx.doi.org/10.1007/s11934-019-0873-9DOI Listing
January 2019
1 Read

Should the Care of Penile Cancer be Confined to Centralized Centers of Excellence?

Authors:
Mohamed H Kamel

Eur Urol Focus 2019 Jan 23. Epub 2019 Jan 23.

Department of Urology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address:

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http://dx.doi.org/10.1016/j.euf.2019.01.013DOI Listing
January 2019
1 Read

Surgical managements of pseudoepitheliomatous keratotic and micaceous balanitis: A case report.

Int J Surg Case Rep 2019 Jan 19;55:37-40. Epub 2019 Jan 19.

Department of Urology, Inje University, Haeundae Paik Hospital, Busan, Republic of Korea. Electronic address:

Introduction: Pseudoepitheliomatous keratotic and micaceous balanitis (PKMB) is an extremely rare disease. Herein, we report a case of PKMB in a patient who underwent two surgical procedures, since the 5-FU cream was not available.

Presentation Of Case: A 50 year-old Korean man undergoing circumcision in a local clinic presented with a tumor-like lesion on the glans penis. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351345PMC
January 2019
3 Reads

Penile Cancer Management in the United States: Regional Centers of Expertise are Needed!

Ann Surg Oncol 2019 Jan 25. Epub 2019 Jan 25.

The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

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http://link.springer.com/10.1245/s10434-019-07178-1
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http://dx.doi.org/10.1245/s10434-019-07178-1DOI Listing
January 2019
3 Reads

Aberrant CEACAM19 expression is associated with metastatic phenotype in penile cancer.

Cancer Manag Res 2019 14;11:715-725. Epub 2019 Jan 14.

Laboratory of Oncology Research, Department of Oncology, Xiangya Hospital, Central South University, Changsha, Human 410008, P.R. China,

Objective: A greater knowledge of the mechanisms of the pathogenesis of penile cancers may assist in the development of more tailored targeted therapy. Herein, we aimed to evaluate the expression of CEACAM19 in penile cancer and to explore its regulatory mechanisms.

Material And Methods: This retrospective study enrolled 64 penile cancer patients who underwent penectomy between 2011 and 2015. Read More

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http://dx.doi.org/10.2147/CMAR.S192385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338120PMC
January 2019
2 Reads

Initial experience of video endoscopic inguinal Lymphadenectomy in a center located at northeast brazilian region.

Int Braz J Urol 2018 Dec 30;45. Epub 2018 Dec 30.

Departamento de Urologia, Faculdade de Medicina do ABC, Santo André, SP, Brasil.

Introduction: Video endoscopic inguinal lymphadenectomy - VEIL - has emerged as an alternative to reduce post-surgical complications (PSC) in patients with penile cancer submitted to inguinal lymphadenectomy (IL). In some series, these PSC are observed in more than 50% of patients. The objectives of the present study are to describe the initial experience of VEIL in a Hospital in Teresina, PI, Brazil, and to analyze PSC incidence. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0521DOI Listing
December 2018
1 Read

Systematic review and evidence synthesis of non-cervical human papillomavirus-related disease health system costs and quality of life estimates.

Sex Transm Infect 2019 Feb 21;95(1):28-35. Epub 2018 Sep 21.

National Infection Service, Public Health England, London, UK

Background: Many economic evaluations of human papillomavirus vaccination should ideally consider multiple disease outcomes, including anogenital warts, respiratory papillomatosis and non-cervical cancers (eg, anal, oropharyngeal, penile, vulvar and vaginal cancers). However, published economic evaluations largely relied on estimates from single studies or informal rapid literature reviews.

Methods: We conducted a systematic review of articles up to June 2016 to identify costs and utility estimates admissible for an economic evaluation from a single-payer healthcare provider's perspective. Read More

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http://sti.bmj.com/lookup/doi/10.1136/sextrans-2018-053606
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http://dx.doi.org/10.1136/sextrans-2018-053606DOI Listing
February 2019
5 Reads

Genital Herpes Zoster as Possible Indicator of HIV Infection.

Acta Dermatovenerol Croat 2018 Dec;26(4):337-338

Associate Professor Suzana Ljubojević Hadžavdić, MD, PhD, Department of Dermatology and Venereology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Šalata 4, 10000 Zagreb, Croatia;

Herpes zoster (HZ) is an acute, cutaneous viral infection caused by the reactivation of varicella-zoster virus (VZV) (1). It is a frequent medical condition with an incidence rate of 2-3 cases per 1000 person/years in the general population and 7-10 cases per 1000 person/years after the age of 50 (1,2). Risk factors and triggers for reactivation of HZV have not yet been determined precisely, but are likely to include malignancies, immune deficiencies, solid organ and bone marrow transplant recipients, autoimmune diseases, psychological conditions, emotional stress, human immunodeficiency virus (HIV) infection, and other patients receiving immunosuppressive therapies (1,3). Read More

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December 2018
7 Reads

Dual Prosthetic Implantation After Radical Cystoprostatectomy and Neobladder: Outcomes of the Inflatable Penile Prosthesis and Artificial Urinary Sphincter in Bladder Cancer Survivors.

Urology 2019 Jan 18. Epub 2019 Jan 18.

USC Institute of Urology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Objectives: To determine the impact of radical cystectomy and orthotopic neobladder (NB) diversion on device-related outcomes in patients who undergo subsequent placement of both, an artificial urinary sphincter (AUS) and 3-piece inflatable penile prosthesis.

Materials And Methods: Using an institutional prosthetic database, we identified 39 patients who underwent radical cystectomy and NB and subsequent implantation of both prosthetic devices from 2003 to 2017. Patient demographics, perioperative data, and postoperative outcomes including prosthetic infection, mechanical failure, revision surgery, and functional outcomes were examined and compared to an appropriate matched group of patients (n = 48, non-neobladder group). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00904295193006
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http://dx.doi.org/10.1016/j.urology.2019.01.010DOI Listing
January 2019
8 Reads

Mean treatment cost of incident cases of penile cancer for privately insured patients in the United States.

Urol Oncol 2019 Jan 16. Epub 2019 Jan 16.

Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX.

Purpose: The aims of this study were to estimate the short-term cost of treating newly diagnosed penile cancer and determine the correlates of penile cancer treatment cost in the United States.

Methods: The Truven MarketScan database was used to identify commercially insured patients with penile cancer newly diagnosed during 2011 to 2014. A control group without HPV-related cancer diagnosis was selected by matching to the case group by the propensity score method. Read More

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http://dx.doi.org/10.1016/j.urolonc.2019.01.004DOI Listing
January 2019
3 Reads

Pre-vaccination prevalence of anogenital and oral human papillomavirus in young HIV-infected men who have sex with men.

Papillomavirus Res 2019 Jan 15;7:52-61. Epub 2019 Jan 15.

Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Electronic address:

The aims of this study were to: 1) determine prevalence of anogenital and oral HPV, 2) determine concordance between HPV at anal, perianal, scrotal/penile, and oral sites; and 3) describe factors associated with anogenital HPV types targeted by the 9-valent vaccine. Data were collected from 2012 to 2015 among men who have sex with men 18-26 years of age enrolled in a vaccine trial (N = 145). Penile/scrotal, perianal, anal, and oral samples were tested for 61 HPV types. Read More

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http://dx.doi.org/10.1016/j.pvr.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356116PMC
January 2019
1 Read

Human papillomavirus vaccine for children and adolescents.

Paediatr Child Health 2018 Jul 12;23(4):262-265. Epub 2018 Jun 12.

Canadian Paediatric Society, Infectious Diseases and Immunization Committee, Ottawa, Ontario.

Human papillomavirus (HPV) is known to cause genital warts, cervical cancer, penile cancer, anal cancer and oropharyngeal cancer. In North America, the lifetime cumulative incidence of HPV infection is estimated at more than 70% for all HPV types combined. A safe and effective vaccine against nine HPV types is available. Read More

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https://academic.oup.com/pch/article/23/4/262/5036413
Publisher Site
http://dx.doi.org/10.1093/pch/pxx179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007323PMC
July 2018
12 Reads

Sperm preservation by electroejaculation before anticancer therapy.

Scand J Urol 2019 Jan 17:1-3. Epub 2019 Jan 17.

a Department of Urology , Aarhus University Hospital , Denmark.

Background: This report presents a case where electroejaculation (EEJ) was used for semen cryopreservation (SCP), prior to gonadotoxic anti-cancer treatment in a 14-year old boy diagnosed with Hodgkins disease.

Method: Two sessions of EEJ were performed with an interval of 48 hours.

Results: No complications were seen and the procedures resulted in nine frozen straws of motile spermatozoa. Read More

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https://www.tandfonline.com/doi/full/10.1080/21681805.2018.1
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http://dx.doi.org/10.1080/21681805.2018.1534883DOI Listing
January 2019
5 Reads

No Evidence of Microsatellite Instability and Loss of Mismatch-Repair-Protein Expression in Squamous Cell Carcinoma of the Penis.

Pathobiology 2019 Jan 16:1-7. Epub 2019 Jan 16.

Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Objective: Microsatellite instability (MSI) and a defective mismatch repair (MMR) system were described as beneficial tumor features for response to immune checkpoint therapy (PD-1 blockade). Meanwhile, the FDA approved PD-1/PD-L1 inhibition treatment for any solid tumor showing MSI and/or defects in the MMR system. For squamous cell carcinoma (SCC) of the penis, no data on the frequency of MSI and altered MMR protein expression are available to date. Read More

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https://www.karger.com/Article/FullText/495251
Publisher Site
http://dx.doi.org/10.1159/000495251DOI Listing
January 2019
4 Reads

Increased risk of HPV-associated genital cancers in men and women as a consequence of pre-invasive disease.

Int J Cancer 2019 Jan 16. Epub 2019 Jan 16.

Institute of Cancer Sciences, University of Glasgow, McGregor Building (Level 1), University Avenue, Glasgow, G12 8QQ.

To assess the excess risk of HPV-associated cancer (HPVaC) in two at-risk groups - women with a previous diagnosis of high grade cervical intraepithelial neoplasia (CIN3) and both men and women treated for non-cervical pre-invasive ano-genital disease. All CIN3 cases diagnosed in 1989-2015 in Scotland were extracted from the Scottish cancer registry (SMR06). All cases of pre-invasive penile, anal, vulval, and vaginal disease diagnosed in 1990-2015 were identified within the NHS pathology databases in the two largest NHS health boards in Scotland. Read More

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http://dx.doi.org/10.1002/ijc.32126DOI Listing
January 2019
2 Reads

Trends in Risks for Second Primary Cancers Associated With Index Human Papillomavirus-Associated Cancers.

JAMA Netw Open 2018 Sep 7;1(5):e181999. Epub 2018 Sep 7.

Department of Management Policy and Community Health, The University of Texas Health Science Center at Houston, School of Public Health, Houston.

Importance: In the last 4 decades, survival among patients with human papillomavirus (HPV)-associated cancers has improved, while the incidence of these cancers has increased among younger cohorts. Among survivors of HPV-associated cancers, persistent HPV infection may remain a risk factor for preventable HPV-associated second primary cancers (HPV-SPCs).

Objectives: To investigate the risk of HPV-SPCs among survivors of HPV-associated index cancers and to test the hypothesis that the HPV-SPC risk among these persons has increased over the last 4 decades. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.1999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324459PMC
September 2018
6 Reads

Prostate-Confined Radiation Decreased Pelvic Ganglia Neuronal Survival and Outgrowth.

J Sex Med 2019 Jan;16(1):27-41

Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA. Electronic address:

Background: Erectile dysfunction (ED) is common following radiation therapy (RT) for prostate cancer. Although the cause of RT-induced ED is unknown, damage to both the neuronal and vascular components supporting erections are often implicated.

Aim: To determine the effects of prostatic RT on erections, penile vascular physiology, and major pelvic ganglia (MPG) neuron growth and survival in a rat model. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.11.010DOI Listing
January 2019
2 Reads

Re: HPV vaccination for penile cancer eradication: cost effectiveness view.

Int Braz J Urol 2019 Jan 5;45. Epub 2019 Jan 5.

Honoary Professor, Dr. DY Patil University, Pune, India.

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0659DOI Listing
January 2019

Continuous Spatial Sequences of Lichen Sclerosus, Penile Intraepithelial Neoplasia, and Invasive Carcinomas: A Study of 109 Cases.

Int J Surg Pathol 2019 Jan 7:1066896918820960. Epub 2019 Jan 7.

1 Instituto de Patología e Investigación, Asunción, Paraguay.

Lichen sclerosus (LSc) with penile cancer is found in about two thirds of specimens. It has been hypothesized that LSc represents a precancerous condition. To qualify as such, in addition to cytological atypia and similarity with the invasive tumor, a spatial correlation between LSc and neoplastic lesions needs to be demonstrated. Read More

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http://journals.sagepub.com/doi/10.1177/1066896918820960
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http://dx.doi.org/10.1177/1066896918820960DOI Listing
January 2019
3 Reads

The Role of Nocturnal Penile Tumescence and Rigidity (NPTR) Monitoring in the Diagnosis of Psychogenic Erectile Dysfunction: A Review.

Sex Med Rev 2019 Jan 3. Epub 2019 Jan 3.

Division of Urology, Department of Surgery, University of Texas McGovern Medical School at Houston, Houston, Texas, USA; University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

Introduction: Nocturnal penile tumescence and rigidity (NPTR) monitoring with RigiScan was considered one of the most reliable methods to differentiate psychogenic erectile dysfunction (pED) from organic ED. However, its reliability has been questioned because of some limitations in the practice.

Aim: To present contemporary views on the role of NPTR monitoring in the diagnosis of pED. Read More

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http://dx.doi.org/10.1016/j.sxmr.2018.10.005DOI Listing
January 2019
1 Read

Multi-observer contouring of male pelvic anatomy: Highly variable agreement across conventional and emerging structures of interest.

J Med Imaging Radiat Oncol 2019 Jan 4. Epub 2019 Jan 4.

Centre for Medical Radiation Physics, University of Wollongong, Wollongong, New South Wales, Australia.

Introduction: This study quantified inter-observer contouring variations for multiple male pelvic structures, many of which are of emerging relevance for prostate cancer radiotherapy progression and toxicity response studies.

Methods: Five prostate cancer patient datasets (CT and T2-weighted MR) were distributed to 13 observers for contouring. CT structures contoured included the clinical target volume (CTV), seminal vesicles, rectum, colon, bowel bag, bladder and peri-rectal space (PRS). Read More

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http://dx.doi.org/10.1111/1754-9485.12844DOI Listing
January 2019
2 Reads

Editorial: penile cancer.

Curr Opin Urol 2019 Mar;29(2):143-144

Department of Urology, Moffitt Cancer Center, University of South Florida, Tampa, Florida, USA.

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http://Insights.ovid.com/crossref?an=00042307-201903000-0001
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http://dx.doi.org/10.1097/MOU.0000000000000586DOI Listing
March 2019
3 Reads

Organ-sparing surgical and nonsurgical modalities in primary penile cancer treatment.

Curr Opin Urol 2019 Mar;29(2):156-164

Department of Urology, University Hospitals of Leuven, Leuven, Belgium.

Purpose Of Review: To provide an overview of the current state of literature on organ-sparing approaches in penile cancer. Surgical as well as nonsurgical approaches can be adapted in the right setting, in an effort to spare patients from the burden of total or subtotal penectomy wherever possible. In this review, we focus on surgical approaches. Read More

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http://Insights.ovid.com/crossref?an=00042307-201903000-0001
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http://dx.doi.org/10.1097/MOU.0000000000000587DOI Listing
March 2019
2 Reads

Minimally invasive approaches to the inguinal nodes in cN0 patients.

Curr Opin Urol 2019 Mar;29(2):165-172

Department of Urology, Emory University School of Medicine, Atlanta, Georgia, USA.

Purpose Of Review: In penile cancer, lymphadenectomy can have staging and possibly therapeutic values. However, many physicians and patients are reluctant when it comes to inguinal lymph node dissection (ILND) due to high rate of surgical morbidities. In recent years, minimally invasive surgical approaches have shown success in reducing perioperative morbidities. Read More

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http://Insights.ovid.com/crossref?an=00042307-900000000-9913
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http://dx.doi.org/10.1097/MOU.0000000000000588DOI Listing
March 2019
1 Read

Recent developments in penile cancer imaging.

Curr Opin Urol 2019 Mar;29(2):150-155

Department of Nuclear Medicine, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Purpose Of Review: This review discusses new findings in penile cancer imaging in relation to the European Association of Urology and National Comprehensive Cancer Network guidelines.

Recent Findings: For imaging in penile cancer patients who are candidates for organ-sparing primary treatment, ultrasound with Doppler seems to be the method of choice in addition to physical examination. The sentinel node biopsy (SNB) procedure is used to detect small nodal metastases in clinically node-negative patients. Read More

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http://Insights.ovid.com/crossref?an=00042307-201903000-0001
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http://dx.doi.org/10.1097/MOU.0000000000000585DOI Listing
March 2019
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Penile cancer - Incidence, mortality, and survival in Saxony, Germany.

Urol Oncol 2018 Dec 27. Epub 2018 Dec 27.

Epidemiology, Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany. Electronic address:

Objective: Penile cancer is a rare disease in Europe and North America. Cancer registry data were used to estimate the incidence, mortality, and survival of penile cancer in Saxony, Germany.

Methods: Data on incidence were analyzed for the period 1961 to 2012 and mortality for the period 1990 to 2012. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10781439183049
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http://dx.doi.org/10.1016/j.urolonc.2018.12.003DOI Listing
December 2018
9 Reads