7,769 results match your criteria Penile Cancer


Therapeutic efficacy of a human papillomavirus type 16 E7 bacterial exotoxin fusion protein adjuvanted with CpG or GPI-0100 in a preclinical mouse model for HPV-associated disease.

Vaccine 2019 Apr 19. Epub 2019 Apr 19.

TheVax Genetics Vaccine Co., Ltd, Irvine, CA 92618, USA.

Persistent human papillomavirus (HPV) infection is causally linked to the development of several human cancers, including cervical, vulvar, vaginal, anal, penile, and oropharyngeal cancers. To address the need for a therapeutic vaccine against HPV-associated diseases, here we test and compare the immunogenicity and therapeutic efficacy of a bacterial exotoxin fusion protein covalently linked to the HPV16 E7 oncoprotein adjuvanted with CpG or GPI-0100 in the C3.43 preclinical HPV16-transformed tumor model. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.04.043DOI Listing

Challenging the prognostic impact of the new WHO and TNM classifications with special emphasis on HPV status in penile carcinoma.

Virchows Arch 2019 Apr 10. Epub 2019 Apr 10.

Department of Urology and Paediatric Urology, Saarland University, Kirrberger Straße 100, 66424, Homburg, Germany.

The evidence concerning prognostic parameters for clinical decision-making in penile cancer is either weak or missing. We therefore analysed the prognostic value of the revised TNM and WHO classification systems on relapse and survival with special emphasis on HPV status. We collected clinical data and tissue samples of 121 patients from centres in Germany and Russia. Read More

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http://dx.doi.org/10.1007/s00428-019-02566-0DOI Listing

Dominant intraprostatic lesion boosting in sexual-sparing radiotherapy of prostate cancer: A planning feasibility study.

Med Dosim 2019 Apr 4. Epub 2019 Apr 4.

Medical Physics Unit, "Giovanni Paolo II" Foundation, Catholic University of Sacred Heart, Campobasso, Italy.

Aim: Radical radiotherapy of prostate cancer requires a relatively high dose to achieve an optimal tumor control probability and a reduced dose to the critical structures related to the sexual function (S_OARs) in order to avoid erectile dysfunction. The aim of this study was to perform a planning feasibility analysis of a 3-level dose prescription with Simultaneous Integrated Boost (SIB) on the dominant intraprostatic lesion (DIL) and with S_OARs sparing.

Material And Methods: Twelve patients with clinically localized intermediate risk prostate cancer were included. Read More

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http://dx.doi.org/10.1016/j.meddos.2019.01.008DOI Listing
April 2019
2 Reads

End-to-side Somatic-to-autonomic Nerve Grafting to Restore Erectile Function and Improve Quality of Life After Radical Prostatectomy.

Eur Urol 2019 Apr 4. Epub 2019 Apr 4.

Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia; Southern Plastic Surgery, Brighton, Victoria, Australia. Electronic address:

Background: Radical prostatectomy (RP) is recommended for the treatment of men with clinically localised prostate cancer. However, RP is associated with a high incidence of erectile dysfunction (ED), which can impact the quality of life (QoL) significantly.

Objective: To evaluate the effectiveness of end-to-side nerve grafting surgery to restore erectile function and improve sexual QoL in men with ED after RP. Read More

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http://dx.doi.org/10.1016/j.eururo.2019.03.036DOI Listing

Management of erosion of inflatable penile prosthesis reservoir into bladder. A different approach.

Arch Ital Urol Androl 2019 Mar 29;91(1):43-45. Epub 2019 Mar 29.

Department of Urology, Faculty of Medicine, University of Cukurova, Adana.

We report a rare case of erosion of an inflatable penile prosthesis reservoir into the bladder that was managed with a different approach from the literature by preserving the existing reservoir. Inflatable penile implant was applied to a 54-year-old male patient who had undergone with a robot-assisted radical prostatectomy operation due to localized prostate cancer 2 years before. Two months after the operation, the patient referred to our clinic with predominant symptoms of lower urinary tract system associated with scrotal pain and swelling. Read More

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http://dx.doi.org/10.4081/aiua.2019.1.43DOI Listing
March 2019
3 Reads

Strength of belief: Religious commitment, knowledge, and HPV vaccination adherence.

Psychooncology 2019 Mar 31. Epub 2019 Mar 31.

Department of Psychology, Brigham Young University.

Objective: Human papillomavirus infects millions of men and women annually and is a substantial contributing factor in many cancers including oral, penile, anal, and cervical. Vaccination can reduce risk but adherence nationwide, and particularly in highly religious states, is suboptimal. Religious principles of abstinence before marriage and total fidelity following marriage may create a belief of protection through adherence to religious guidelines. Read More

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http://dx.doi.org/10.1002/pon.5071DOI Listing
March 2019
3 Reads

Nail Squamous Cell Carcinoma: A Hidden High-risk HPV Reservoir for Sexually Transmitted Infections.

J Am Acad Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

Human papillomavirus (HPV) causes cervical cancer, anal cancer, vulvar cancer, vaginal cancer, penile cancer and oropharyngeal cancer. SCC in the genital region in particular is recognized to be caused by HPV infection, and intraepithelial lesions of the penis and vulva are termed penile intraepithelial neoplasia (PIN) and vulvar intraepithelial neoplasia (VIN), respectively. Although SCC of the nail apparatus is recognized as being associated with high-risk HPVs, it is not well-known in general medicine, and its analysis has been insufficient. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.070DOI Listing
March 2019
2 Reads

Molecular Detection of Equus caballus Papillomavirus Type 2 in Genital Swabs From Healthy Horses in the Republic of Korea.

J Equine Vet Sci 2019 Jan 21;72:97-100. Epub 2018 Oct 21.

College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea. Electronic address:

Equus caballus papillomavirus type 2 (EcPV-2) is implicated in genital neoplasms in horses, including equine penile papillomas, penile intraepithelial neoplasia, and squamous cell carcinoma (SCC). This virus seldom regresses spontaneously and can result in the development of SCC, which may result in significant clinical damage and economic cost. However, the prevalence of this virus is unknown in clinically unaffected horses. Read More

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http://dx.doi.org/10.1016/j.jevs.2018.10.015DOI Listing
January 2019
2 Reads

[Primary penile cancer: about 11 cases and literature review].

Pan Afr Med J 2018 4;31:14. Epub 2018 Sep 4.

Service de Chirurgie Carcinologique, Institut Salah Azaiz de Tunis, Tunisie.

Penile cancer is a rare pathology in Tunisia where circumcision is a common practice. Squamous cell carcinoma accounts for 95% of cases. Treatment is essentially based on surgery. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.14.13077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430962PMC
April 2019
1 Read

Improving rectal dosimetry for patients with intermediate and high-risk prostate cancer undergoing combined high-dose-rate brachytherapy and external beam radiotherapy with hydrogel space.

J Contemp Brachytherapy 2019 Feb 28;11(1):8-13. Epub 2019 Feb 28.

The Austin Hospital, Heidelberg, Australia.

Purpose: To report on rectal dosimetric and toxicity outcomes of intermediate and high-risk prostate cancer patients undergoing combined high-dose-rate (HDR) brachytherapy and external beam radiotherapy (EBRT) with or without hydrogel spacer (HS) insertion.

Material And Methods: A total of 97 patients were analyzed in this study, with 32 patients (33%) who had HS insertion compared with a preceding group of 65 patients (67%) without HS. HS safety, the dosimetric effects on organs at risk (rectal, urethral, penile bulb, and bladder) as well as gastrointestinal (GI) and genitourinary toxicity were evaluated and compared between the two groups. Read More

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http://dx.doi.org/10.5114/jcb.2019.82836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431099PMC
February 2019
1 Read

Rare Genitourinary Malignancies: Current Status and Future Directions of Immunotherapy.

Eur Urol Focus 2019 Mar 22. Epub 2019 Mar 22.

Genitourinary Oncology Division, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Electronic address:

Treatment options for rare genitourinary malignancies, including adrenocortical carcinoma, bladder/upper tract cancers of variant histology, penile squamous cell carcinoma, and chemotherapy-refractory germ cell tumors, are limited, often with a poor response to systemic therapy. Given preclinical data and efficacy across multiple malignancies, immunotherapy has been and continues to be explored in this challenging setting. In this report, we explore the data for immunotherapy in these tumors and highlight ongoing clinical trials. Read More

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http://dx.doi.org/10.1016/j.euf.2019.03.011DOI Listing
March 2019
1 Read

Spectrum of urogenital tumors in males in Sub-Himalayan region: An institutional experience.

J Cancer Res Ther 2019 Mar;15(Supplement):S82-S86

Department of Urology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Aims: The clinical presentation and frequency of urogenital tumors varies in different regions of the world. This study was undertaken to analyze the frequency, clinical presentation, and the histopathological spectrum of the various male urogenital tumors diagnosed over a period of 3 years in a tertiary care institute.

Materials And Methods: Three-year data were collected from the histopathology laboratory, which included all the cases of male urogenital tumors which were diagnosed histopathologically between November 2012 and October 2015. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_565_17DOI Listing
March 2019
3 Reads

Maximizing rectal dose sparing with hydrogel: A retrospective planning study.

J Appl Clin Med Phys 2019 Apr 19;20(4):91-98. Epub 2019 Mar 19.

Department of Radiation Oncology, BC Cancer - Victoria, Victoria, BC, Canada.

External beam radiation therapy for prostate cancer can result in urinary, sexual, and rectal side effects, often impairing quality of life. A polyethylene glycol-based product, SpaceOAR© hydrogel (SOH), implanted into the connective tissue between the prostate gland and rectum can significantly reduce the dose received by the rectum and hence risk of rectal toxicity. The optimal way to manage the hydrogel and rectal structures for plan optimization is therefore of interest. Read More

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http://dx.doi.org/10.1002/acm2.12566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448161PMC
April 2019
1 Read

Circumcision to prevent HIV and other sexually transmitted infections in men who have sex with men: a systematic review and meta-analysis of global data.

Lancet Glob Health 2019 Apr;7(4):e436-e447

School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China; Shenzhen Center for Disease Control and Prevention, Shenzhen, China; School of Public Health, and Sun Yat-sen Global Health Institute, Institute of State Governance, Sun Yat-sen University, Guangzhou, China; Kirby Institute, University of New South Wales, Sydney, NSW, Australia. Electronic address:

Background: Men who have sex with men (MSM) are disproportionately affected by HIV and other sexually transmitted infections (STIs) worldwide. Previous reviews investigating the role of circumcision in preventing HIV and other STIs among MSM were inconclusive. Many new studies have emerged in the past decade. Read More

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http://dx.doi.org/10.1016/S2214-109X(18)30567-9DOI Listing
April 2019
1 Read

Perplexity of penile rehabilitation following radical prostatectomy.

Turk J Urol 2019 Jan 22;45(2):77-82. Epub 2019 Jan 22.

Department of Surgery, Division of Urology, University of Texas Health Science Center- McGovern Medical School at Houston, Houston, Texas, USA.

Radical prostatectomy has significantly improved prostate cancer survival rates but continues to have a negative impact on the patient's erectile function (EF). In attempts to improve erectile dysfunction (ED), clinicians have incorporated different treatment modalities to restore EF. Penile rehabilitation consists of understanding the mechanisms that affect post-prostatectomy EF and utilizing pharmacologic agents, devices, and interventions to promote the male sexual function. Read More

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http://dx.doi.org/10.5152/tud.2019.18488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368034PMC
January 2019
1 Read

Defining the Tumor Microenvironment of Penile Cancer by Means of the Cancer Immunogram.

Eur Urol Focus 2019 Mar 9. Epub 2019 Mar 9.

Department of Gynecology, Center for Gynecologic Oncology Amsterdam, Amsterdam University Medical Center VUmc, Amsterdam, The Netherlands. Electronic address:

Current chemotherapeutic treatment for advanced penile squamous cell carcinoma has substantial side effects and no randomized data to support an overall survival benefit. Immunotherapy with checkpoint blockade is currently being tested in penile cancer patients in clinical trials. The high PD-L1 expression and CD8 T-cell infiltration in penile cancer represent a promising prospect for immunotherapy response in the treatment of locally advanced disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24054569193005
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http://dx.doi.org/10.1016/j.euf.2019.02.019DOI Listing
March 2019
6 Reads

F-Fluoride Positron Emission Tomographic Imaging of Penile Arteries and Erectile Dysfunction.

J Am Coll Cardiol 2019 Apr 4;73(12):1386-1394. Epub 2019 Mar 4.

Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, New York; Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:

Background: Fluorine-18 sodium fluoride (NaF), a bone-seeking radiopharmaceutical used to detect osseous metastases, localizes in regions of microcalcification in atherosclerosis.

Objectives: To determine if atherosclerosis of penile arteries plays a role in erectile dysfunction (ED), this study analyzed NaF images in prostate cancer patients.

Methods: NaF positron emission tomography-computed tomography bone scans were evaluated in 437 prostate cancer patients (age 66. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.10.076DOI Listing
April 2019
9 Reads

Discovery, characterisation and genomic variation of six novel Gammapapillomavirus types from penile swabs in South Africa.

Papillomavirus Res 2019 Mar 4;7:102-111. Epub 2019 Mar 4.

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, 7925, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; SAMRC Gynaecological Cancer Research Centre, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. Electronic address:

Six novel human papillomaviruses from penile swabs were characterised. Multiple full genome clones for each novel type were generated, and complete genome sizes were: HPV211 (7253bp), HPV212 (7208bp), HPV213 (7096bp), HPV214 (7357), HPV215 (7186bp) and HPV216 (7233bp). Phylogenetically the novel papillomaviruses all clustered with Gammapapillomaviruses: HPV211 is most closely related to HPV168 (72% identity in the L1 nucleotide sequence) of the Gamma-8 species, HPV212 is most closely related to HPV144 (82. Read More

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http://dx.doi.org/10.1016/j.pvr.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416656PMC
March 2019
1 Read

Meta-analysis of penile cancer: conceptual interpretations - Authors' reply.

Lancet Oncol 2019 Mar;20(3):e126

Unit of Virus, Lifestyle, and Genes, Danish Cancer Society Research Centre, DK-2100 Copenhagen, Denmark; Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(19)30108-1DOI Listing

Meta-analysis of penile cancer: conceptual interpretations.

Lancet Oncol 2019 Mar;20(3):e125

School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.

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http://dx.doi.org/10.1016/S1470-2045(19)30023-3DOI Listing

Potential effectiveness of prophylactic HPV immunization for men who have sex with men in the Netherlands: A multi-model approach.

PLoS Med 2019 Mar 4;16(3):e1002756. Epub 2019 Mar 4.

Cluster of Infectious Diseases, Public Health Service of Amsterdam (GGD), Amsterdam, The Netherlands.

Background: Men who have sex with men (MSM) are at high risk for anal cancer, primarily related to human papillomavirus genotype 16 (HPV16) infections. At 8.5 per 100,000 per year, the incidence rate of anal cancer among MSM is similar to that of cervical cancer among adult women in the Netherlands. Read More

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http://dx.plos.org/10.1371/journal.pmed.1002756
Publisher Site
http://dx.doi.org/10.1371/journal.pmed.1002756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398832PMC
March 2019
7 Reads

Uncommon Penio-Scrotal Metastases of Prostate Cancer Detected on 68Ga PSMA PET/CT.

Clin Nucl Med 2019 May;44(5):424-425

From the Department of Nuclear Medicine and PET/CT, Mahajan Imaging Centre, and.

A 68-year-old man, a known case of carcinoma prostate (Gleason score 4 + 4), status post transurethral resection of prostate cancer and radiotherapy, on hormonal treatment with rising prostate-specific antigen 9.0 ng/mL and penile swelling underwent Ga-PSMA PET/CT scan for metastatic workup and restaging. The study revealed abnormal tracer uptake in the prostatic bed region, the pelvic and inguinal lymph nodes, and metastases to the glans of penis and scrotum. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002527DOI Listing
May 2019
2 Reads

Adherence to the EAU guidelines on Penile Cancer Treatment: European, multicentre, retrospective study.

J Cancer Res Clin Oncol 2019 Apr 1;145(4):921-926. Epub 2019 Mar 1.

Department of Urology, G. D'Annunzio University, Chieti, Italy.

Purpose: The European Association of Urology (EAU) guidelines for penile cancer (PC) are exclusively based on retrospective studies and have low grades of recommendation. The aim of this study was to assess the adherence to guidelines by investigating the management strategies for primary tumours and inguinal lymph nodes.

Methods: We retrospectively reviewed the clinical charts of 176 PC patients who underwent surgery in eight European centres from 2010 to 2016. Read More

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http://dx.doi.org/10.1007/s00432-019-02864-9DOI Listing
April 2019
3 Reads

Human Papillomavirus and Genital Disease in Men: What We Have Learned from the HIM Study.

Acta Cytol 2019 Feb 22;63(2):109-117. Epub 2019 Feb 22.

Center for Translational Research in Oncology, Instituto do Cancer do Estado de Sao Paulo, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Brazil,

It is currently recognized that in addition to the major impact of human papillomavirus (HPV) infection in females, HPV causes considerable disease in men at the genitals, anal canal, and oropharynx. Specifically, genital HPV infections may progress to genital warts and penile carcinoma. Although studies concerning the natural history of HPV infections and associated neoplasias have mainly focused on women, during the last 2 decades considerable attention has been given in further understanding these infections in men. Read More

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http://dx.doi.org/10.1159/000493737DOI Listing
February 2019
4 Reads

Opportunities for use of radiation therapy in penile cancer based on patterns of care in the United States from 2007 to 2013.

Ther Adv Urol 2019 Jan-Dec;11:1756287219828972. Epub 2019 Feb 8.

Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, KS, USA.

Background: Radiation therapy (RT) is an effective modality for the treatment of squamous cell carcinomas of the penis. The National Comprehensive Cancer Network recommends consideration of primary radiation for penile preservation, in surgically unresectable tumors, and as adjuvant therapy for positive margins, bulky groin nodes or pelvic nodes. We performed a population-based analysis to evaluate the usage of RT in penile cancer from 2007 to 2013. Read More

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http://dx.doi.org/10.1177/1756287219828972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376511PMC
February 2019
2 Reads

Palmar-plantar Erythrodysesthesia with Genital Involvement Secondary to Capecitabine Chemoradiotherapy: A Case Report.

Cureus 2018 Dec 8;10(12):e3704. Epub 2018 Dec 8.

Radiation Oncology, London Regional Cancer Program, Western University, London, CAN.

Palmar-plantar erythrodysesthesia (PPE) is a common dermatologic adverse reaction secondary to capecitabine use, but the skin toxicity rarely involves the genitals. We describe a case of PPE with scrotal and penile involvement secondary to capecitabine chemotherapy concurrent with radiotherapy. The patient presented with pain and erythema involving the penis and scrotum during the fifth week of neoadjuvant chemoradiotherapy with capecitabine for T3c N2b M0 low rectal adenocarcinoma. Read More

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http://dx.doi.org/10.7759/cureus.3704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373891PMC
December 2018

Non-Infectious Reservoir-Related Complications During and After Penile Prosthesis Placement.

Sex Med Rev 2019 Feb 18. Epub 2019 Feb 18.

Division of Urology, University of Texas Health Science Center-McGovern Medical School at Houston, Department of Surgery, Houston, TX, USA; University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Introduction: Inflatable penile prosthesis (IPP) surgery offers a high satisfaction rate and low rate of complications when performed by experienced surgeons. However, reservoir placement, either in the space of Retzius (SOR), or alternative/ectopic locations, may lead to an array of serious complications that may require revision surgery.

Aim: To review the prevalence and management options for non-infectious intraoperative and postoperative complications related to prosthetic reservoirs. Read More

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http://dx.doi.org/10.1016/j.sxmr.2018.12.005DOI Listing
February 2019

Metastasis in penile corpus cavernosum from esophageal squamous carcinoma after curative resection: a case report.

BMC Cancer 2019 Feb 20;19(1):162. Epub 2019 Feb 20.

Department of Urology, Ningbo Urology & Nephrology Hospital, Ningbo, 315192, Zhejiang, China.

Background: Metastasis in penile corpus cavernosum from esophageal squamous carcinoma is a rare but fatal disease, which was reported in cases without series studies.

Case Presentation: An 84-year-old male smoker, who had a history of curative resection of esophageal squamous carcinoma 12 months before, presented with aggressive dysuria and penis pain for 1 month. Ultrasonic guided biopsy diagnosed metastatic squamous carcinoma from the primary in the esophagus. Read More

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http://dx.doi.org/10.1186/s12885-019-5356-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381745PMC
February 2019
2 Reads

[Complications of transperineal template-guided prostate mapping biopsy].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):428-431

Department of Urology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China.

To assess the complications of transperineal template-guided prostate mapping biopsy (TTMB). Between May 2017 and March 2018, 142 consecutive patients with prior negative transrectal biopsy results and persistently elevated prostate-specific antigen (PSA) were divided into the observation group and the control group randomly. The observation group underwent TTMB and the control group underwent transperineal template-guided prostate saturation biopsy (TTSB). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.009DOI Listing
February 2019
1 Read

Treatment Options and Outcomes of Penile Constriction Devices.

Int Braz J Urol 2019 Feb 10;45. Epub 2019 Feb 10.

Hospital Municipal Souza Aguiar, Rio de Janeiro, RJ, Brasil.

Purpose: To study the effect of penile constriction devices used on a large series of patients who presented at our emergency facility. We explored treatment options to prevent a wide range of vascular and mechanical injuries occurring due to penile entrapment.

Materials And Methods: Between January 2001 and March 2016, 26 patients with penile entrapment were admitted to our facility and prospectively evaluated. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0667DOI Listing
February 2019

Kaposi sarcoma of th e penis in anHIV-negative patient.

Einstein (Sao Paulo) 2019 Feb 18;17(1):eRC4504. Epub 2019 Feb 18.

Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain.

Kaposi sarcoma is an angioproliferative disorder that ranges from a single indolent skin lesion to respiratory and gastrointestinal/visceral involvement. Kaposi sarcoma is rare in non-immunosuppressed patients. Nineteen cases of penile Kaposi sarcoma in HIV-negative patients were reported in 2012. Read More

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http://dx.doi.org/10.31744/einstein_journal/2019RC4504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377042PMC
February 2019
2 Reads

A Systematic Review of the Role of Penile Rehabilitation in Prostate Cancer Patients Receiving Radiotherapy and Androgen Deprivation Therapy.

J Med Imaging Radiat Sci 2019 Mar 26;50(1):171-178. Epub 2018 Oct 26.

Directorate of Radiotherapy, University of Liverpool, Liverpool, UK. Electronic address:

Introduction/background: Treatment-induced erectile dysfunction (ED) is a common side effect of radiotherapy and androgen deprivation therapy (ADT) that impacts on patient quality of life. Penile rehabilitation interventions including pharmacologic and physical therapies aim to reduce the impact of ED. Despite The National Institute for Health and Care Excellence guidelines recommending access to ED services, penile rehabilitation is not widely discussed or implemented. Read More

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http://dx.doi.org/10.1016/j.jmir.2018.09.004DOI Listing
March 2019
1 Read

A 3D-Printed Patient-Specific Phantom for External Beam Radiation Therapy of Prostate Cancer.

J Eng Sci Med Diagn Ther 2018 Nov 6;1(4). Epub 2018 Aug 6.

Department of Radiology, Boston Medical Center & Boston University School of Medicine, 820 Harrison Ave., Boston, MA 02118.

This paper presents the design evolution, fabrication, and testing of a novel patient and organ-specific, 3D printed phantom for external beam radiation therapy of prostate cancer. In contrast to those found in current practice, this phantom can be used to plan and validate treatment tailored to an individual patient. It contains a model of the prostate gland with a dominant intraprostatic lesion, seminal vesicles, urethra, ejaculatory duct, neurovascular bundles, rectal wall, and penile bulb generated from a series of combined T2-weighted/dynamic contrast-enhanced magnetic resonance images. Read More

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http://dx.doi.org/10.1115/1.4040817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376205PMC
November 2018
3 Reads

National Trends in Human Papillomavirus Awareness and Knowledge of Human Papillomavirus-Related Cancers.

Am J Prev Med 2019 Apr 14;56(4):e117-e123. Epub 2019 Feb 14.

Behavioral Research Program, National Cancer Institute, Bethesda, Maryland.

Introduction: The President's Cancer Panel released a report in 2014 calling for communication strategies to promote the human papillomavirus vaccine among males and females. The purpose of this study was to (1) estimate changes in human papillomavirus awareness and knowledge of human papillomavirus-related cancers from 2014 to 2017 using a nationally representative survey of adults in the U.S. Read More

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http://dx.doi.org/10.1016/j.amepre.2018.11.005DOI Listing
April 2019
1 Read

Trans-Fascial Placement of a High, Sub Muscular Reservoir in Patients Following Radical Cystectomy: Safety, Efficacy, and Predictability of Final Reservoir Location Verified With Abdominal Imaging.

J Sex Med 2019 Feb;16(2):338-345

Department of Urology, University of Miami Miller School of Medicine, Miami, FL, USA.

Introduction: With the increasing utilization of ectopic reservoir placement during multicomponent penile implant surgery, safety concerns have been raised about whether passing the reservoir through the floor of the inguinal canal consistently results in placement of the reservoir within the correct location.

Aim: To evaluate the safety, efficacy, and patient satisfaction associated with direct-vision, trans-fascial sub muscular reservoir placement in consecutive patients who had previously undergone radical cystectomy.

Methods: Perioperative data, complications, and follow up for the 12 cystectomy patients were evaluated using a comprehensive database of consecutive patients undergoing penile prosthesis placement at our center. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.12.015DOI Listing
February 2019
2 Reads
3.151 Impact Factor

High-Dose Rate Brachyther-apy in the Treatment of Early Stages of Penile Carcinoma.

Klin Onkol 2019 ;32(1):52-57

Background: Interstitial low dose rate brachyther-apy is established organ spar-ing treatment of T1- T2 penile carcinoma. Experience with high-dose rate brachyther-apy is limited in this indication.

Materials And Methods: Twenty-six patients with early penile carcinoma were treated by high-dose rate brachyther-apy at dose 18 × 3 Gy per fraction twice daily between 2002- 2018 at the Department of Oncology and Radiother-apy, University Hospital in Hradec Kralove. Read More

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http://dx.doi.org/10.14735/amko201952DOI Listing
January 2019

Malignant Tumors of the Penis - Dia-gnostics and Therapy.

Klin Onkol 2019 ;32(1):31-39

Background: Penile cancer belongs to group of relatively rare malignancies. It represents, on average, 0.5-1% of all tumours in males globally and occurs predominantly in older individuals (> 65 years). Read More

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https://www.linkos.cz/files/klinicka-onkologie/449/5462.pdf
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http://dx.doi.org/10.14735/amko201931DOI Listing
January 2019
1 Read

Dose to the penile bulb and individual patient anatomy are predictive of erectile dysfunction in men treated with I low dose rate brachytherapy for localized prostate cancer.

Acta Oncol 2019 Feb 14:1-7. Epub 2019 Feb 14.

a Radiation Oncology Department , CHU , Brest , France.

Background: To evaluate the occurrence of erectile dysfunction at 3 years (3yED) after prostate brachytherapy (BT) and to predict 3yED after treatment based on patients and treatments characteristics.

Material And Methods: From September 2007 to July 2015, 117 men with mild or no ED [International Index of Erectile Function (IIEF-5) > 16] underwent Iodine real-time ultrasound-guided low-dose rate BT to a total dose of 160 Gy for low-risk or favorable intermediate-risk prostate adenocarcinoma, and were followed prospectively during 3 years. Median age was 63 years (51-79). Read More

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http://dx.doi.org/10.1080/0284186X.2019.1574981DOI Listing
February 2019
1 Read

More lymph node dissection improves survival in patients with newly diagnosed lymph node-positive penile cancer.

Int Urol Nephrol 2019 Apr 13;51(4):641-654. Epub 2019 Feb 13.

Department of Urology, Shanghai Tenth People's Hospital, Tongji University, No. 301, Yanchang Road, Jing'an District, Shanghai, 200072, China.

Purpose: For patients with lymph node-positive (LN+) penile cancer, the optimal extent of lymph node dissection (LND) is currently not established. We aimed to reveal the potential association between survival and the number of LND in patients with newly diagnosed LN + penile cancer.

Methods: Patients with LN + penile cancer diagnosed between 2004 and 2015 were identified using the SEER database. Read More

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http://dx.doi.org/10.1007/s11255-019-02084-7DOI Listing

Human Papillomavirus Risk Perceptions Among Young Adult Sexual Minority Cisgender Women and Nonbinary Individuals Assigned Female at Birth.

Perspect Sex Reprod Health 2019 03 12;51(1):27-34. Epub 2019 Feb 12.

Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston.

Context: Some sexual minority women may be less likely than other women to engage in human papillomavirus (HPV) prevention behaviors. Although risk perceptions have been found to be associated with health behaviors, HPV risk perceptions among U.S. Read More

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http://dx.doi.org/10.1363/psrh.12087DOI Listing
March 2019
1 Read

Postoperative vacuum therapy following AMS™ LGX 700® inflatable penile prosthesis placement: penile dimension outcomes and overall satisfaction.

Int J Impot Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Urology, Coral Gables Hospital, 3100 Douglas Rd, Coral Gables, FL, 33134, USA.

Penile shortening after inflatable penile prosthesis for erectile dysfunction is a common postoperative patient complaint and can reduce overall satisfaction with the procedure. In this prospective study we report our results regarding penile dimensions and patient satisfaction outcomes after 1 year of follow-up from AMS™LGX700® penile prosthesis implant with 6 months of vacuum erectile device therapy. Seventy-four selected patients with medically refractory erectile dysfunction underwent AMS™ LGX 700® IPP placement. Read More

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http://dx.doi.org/10.1038/s41443-019-0125-zDOI Listing
February 2019

Fertility preservation in male patients with cancer.

Authors:
Shlomi Barak

Best Pract Res Clin Obstet Gynaecol 2019 Feb 20;55:59-66. Epub 2018 Dec 20.

Assuta University Hospital, Ashdod, Israel; Division of Obstetrics and Gynecology, Ben-Gurion University of the Negev, Israel. Electronic address:

Advances in the treatment of cancer in young patients have led to great improvements in life expectancy, which currently approaches 80% 5-year survival rate. As a result, fertility preservation and desire for paternity have become a significant issue in this group. However, a major concern is the negative impact of chemotherapy, radiotherapy, and the malignancy itself on fertility. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2018.12.004DOI Listing
February 2019
2 Reads

Important surgical concepts and techniques in inguinal lymph node dissection.

Curr Opin Urol 2019 May;29(3):286-292

Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida, USA.

Purpose Of Review: Penile cancer is a rare disease with significant physical and psychosocial morbidity. It has a propensity to spread to the inguinal lymph nodes where it can progress to the pelvis and beyond. Here, we present a contemporary review on the surgical management of the lymph nodes. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000591DOI Listing
May 2019
7 Reads
2.333 Impact Factor

The relationship between HPV and penile cancer: Filling a knowledge gap in the general population.

Can Urol Assoc J 2019 Feb;13(2):38

Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL, United States.

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http://dx.doi.org/10.5489/cuaj.5838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363573PMC
February 2019
2 Reads

Optimized penile surface mold brachytherapy using latest stereolithography techniques: A single-institution experience.

Brachytherapy 2019 Feb 1. Epub 2019 Feb 1.

University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Electronic address:

Purpose: To describe a technique of penile surface mold high-dose-rate (HDR) brachytherapy and early outcomes.

Methods And Materials: Five patients diagnosed with a T1aN0 squamous cell carcinoma of the penis were treated using a penile surface mold HDR brachytherapy technique. A negative impression of the penis was obtained using dental alginate. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.01.002DOI Listing
February 2019
3 Reads
1.987 Impact Factor