46,065 results match your criteria Penetrating Neck Trauma
Cell Physiol Biochem 2018 Dec 6;51(5):2019-2029. Epub 2018 Dec 6.
State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-Sen University, Guangzhou,
Background/aims: β-Elemene is a bioactive sesquiterpene compound that exhibits a potent anti-tumor effect and is used in various clinical applications. However, little is known about its effect on the male reproductive system. The objective of this study was to investigate the in vitro actions of β-elemene on human sperm function and elucidate the underlying mechanism. Read More
Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.
Laboratory of Molecular and Cellular Screening Processes, Centre of Biotechnology of Sfax, University of Sfax, Road Sidi Mansour km 6, PO BOX 1177, 3018 Sfax, Tunisia.
A cationic cell-penetrating peptide PEP-NJSM was identified in human virus proteomes by a screening of charge clusters in protein sequences generating cell penetrating peptides (CPP). PEP-NJSM was selectively active against Gram positive Staphylococcus epidermidis as antibacterial agent with MIC value of 128 μM compared to the Gram-negative Pseudomonas aeruginosa strain with MIC value exceeded 512 μM. The selected peptide exhibited an important anti-biofilm activity even at sub-MIC levels. Read More
Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.
Purpose: Scientific publications have recently found that bone graft quality and implant survival rates were not influenced by antrostomy membrane coverage during maxillary sinus floor augmentation with a lateral approach. The aim of this study was to evaluate the stability of the bone substitute after a maxillary sinus floor augmentation procedure with or without using a covering membrane.
Materials And Methods: This retrospective study evaluated all patients who were enrolled between April 2016 and January 2017. Read More
FASEB J 2018 Dec 6:fj201800885RR. Epub 2018 Dec 6.
Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Protein tyrosine (Tyr) nitration, the covalent addition of a nitro group (NO) to Tyr residues, is emerging as a candidate mechanism of endothelial dysfunction. Previous studies have shown that Tyr nitration is primarily induced by nitrosative stress, a process characterized by the production of reactive nitrogen species, especially peroxynitrite anion (ONOO), which is considered a secondary product of NO in the presence of superoxide radicals (O). However, the impact of nitrosative stress-induced Tyr nitration on endothelial dysfunction has not been thoroughly elucidated to date. Read More
Ugeskr Laeger 2018 Dec;180(49)
Traumatic rectal lesions can be seen in both blunt and penetrating traumas and are associated with a high morbidity and high mortality. This is a review of the literature on diagnosis and treatment of intra- and extraperitoneal rectal lesions. There is a consensus, that intraperitoneal rectal lesions should be treated with primary repair alone. Read More
Curr HIV Res 2018 Dec 5. Epub 2018 Dec 5.
Pilot Nano-Biotechnology Department, Pasteur Institute of Iran, Tehran. Iran.
Background: HIV-1 Nef protein is a possible attractive target in development of therapeutic HIV vaccines including protein-based vaccines. The most important disadvantage of protein-based vaccines is their low immunogenicity which can be improved by heat shock proteins (Hsps) as an immunomodulator, and cell penetrating peptides (CPPs) as a carrier.
Methods: In this study, the HIV-1 Nef and Hsp20-Nef proteins were generated in E. Read More
Angiogenesis 2018 Dec 5. Epub 2018 Dec 5.
Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 6309 MBRB, Chapel Hill, NC, 27599-7545, USA.
Vascular dysfunction contributes to the progression and severity of Alzheimer's disease (AD). Patients with AD also sustain larger infarctions after ischemic stroke; however, the responsible mechanisms are unknown. Pial collaterals are the primary source of protection in stroke. Read More
Trauma Case Rep 2018 Dec 24;18:24-27. Epub 2018 Nov 24.
Department of Surgery, University of Colorado, Denver, United States of America.
Introduction: Traumatic arterial injuries have a high degree of morbidity if left untreated. Frequently, arterial injuries are found soon after injury due to either subjective complaints or objective findings. Opportunity for delayed repair of vascular injury is a rare event as irreversible ischemia occurs at such early time points. Read More
Sci Rep 2018 Dec 5;8(1):17641. Epub 2018 Dec 5.
Laboratory of Drug Delivery Systems, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe, Hyogo, 650-8586, Japan.
In a recent study, we demonstrated the potential of a cell-penetrating peptide (CPP) penetratin to deliver the peptide drug insulin to the brain via nasal administration, and its pharmacological effect on the mild cognitive dysfunction in senescence-accelerated mouse (SAMP8). However, the therapeutic potential of intranasal insulin administration was attenuated when applied to the aged SAMP8 with severe cognitive dysfunction. The present study, therefore, aimed to overcome the difficulty in treating severe cognitive dysfunction using insulin by investigating potential alternatives, glucagon-like peptide-1 (GLP-1) receptor agonists such as exendin-4. Read More
J Virol 2018 Dec 5. Epub 2018 Dec 5.
Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
Bluetongue virus (BTV), family , is an insect-borne, double-capsid virus causing haemorrhagic disease in livestock around the world. Here we elucidate how outer capsid proteins VP2 and VP5 coordinate cell entry of BTV. To identify key functional residues, we used atomic-level structural data to guide mutagenesis of VP2 and VP5, and a series of biological and biochemical approaches, including site-directed mutagenesis, reverse genetics-based virus recovery, expression and characterization of individual recombinant mutant proteins and various and assays. Read More
ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.
Glioblastoma multiforme is the most devastating malignant brain tumor in adults. Even with standard-care of therapy, the prognosis remains dismal due to tumor heterogeneity, tumor infiltration, and more importantly, the restrictive nature of the blood-brain barrier (BBB). To overcome the challenge of effectively delivering therapeutic cargo into the brain, herein a "smart," multifunctional polymeric micelle was developed using a cholesterol-conjugated polyoxyethylene sorbitol oleate. Read More
Biomater Sci 2018 Dec 3. Epub 2018 Dec 3.
Royal Society of Chemistry, Thomas Graham House, Science Park, Milton Road, Cambridge, CB4 0WF, UK.
Retraction of 'The next generation cell-penetrating peptide and carbon dot conjugated nano-liposome for transdermal delivery of curcumin' by Santanu Patra et al., Biomater. Sci. Read More
PLoS One 2018 3;13(12):e0207766. Epub 2018 Dec 3.
Vanderbilt University Hospital, Division of Trauma and Surgical Critical Care, Nashville, TN, United States of America.
Background: Increased knowledge of the temporal patterns in the distribution of trauma admissions could be beneficial to staffing and resource allocation efforts. However, little work has been done to understand how this distribution varies based on patient acuity, trauma mechanism or need for intervention. We hypothesize that temporal patterns exist in the distribution of trauma admissions, and that deep patterns exist when traumas are analyzed by their type and severity. Read More
J Vis Exp 2018 Nov 18(141). Epub 2018 Nov 18.
Neurosciences Research Center, Tabriz University of Medical Sciences;
Transcranial photobiomodulation is a potential innovative noninvasive therapeutic approach for improving brain bioenergetics, brain function in a wide range of neurological and psychiatric disorders, and memory enhancement in age-related cognitive decline and neurodegenerative diseases. We describe a laboratory protocol for transcranial photobiomodulation therapy (PBMT) in mice. Aged BALB/c mice (18 months old) are treated with a 660 nm laser transcranially, once daily for 2 weeks. Read More
Eur Spine J 2018 Dec 1. Epub 2018 Dec 1.
Central European Institute of Technology (CEITEC), Masaryk University, Kamenice 753/5, 625 00, Brno, Czech Republic.
Purpose: The presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate the pathology of degenerative disc disease. This hypothesis, therefore, raises the exciting possibility that antibiotics could play an important role in treating this debilitating condition. To date, however, little information about antibiotic penetration into the intervertebral disc is available. Read More
Graefes Arch Clin Exp Ophthalmol 2018 Nov 30. Epub 2018 Nov 30.
Department of Ophthalmology, Rigshospitalet-Glostrup, University of Copenhagen, Glostrup, Denmark.
Purpose: Donor-to-host transmission of infectious agents is a rare but well-recognised complication of corneal transplantation and may carry a grave visual prognosis. In this case series, we describe the clinical features and risk factors of using culture-positive donor corneas for transplantation.
Methods: Retrospective chart review of a series of patients who underwent either penetrating keratoplasty (PK) or Descemet's stripping automated endothelial keratoplasty (DSAEK) with positive microbiology cultivation during routine assessment of donor corneal tissue obtained at the time of surgery. Read More
Am J Ophthalmol Case Rep 2019 Mar 10;13:1-5. Epub 2018 Nov 10.
Medical University of South Carolina, USA.
Purpose: To report clinical outcomes and surgical technique of flanged intrascleral intraocular lens fixation with double-needle combined with either penetrating keratoplasty (PKP) or ultrathin Descemet-stripping automated endothelial keratoplasty (UT-DSAEK).
Observations: Five patients underwent combined flanged intrascleral intraocular lens fixation with double-needle technique and keratoplasty. Three patients underwent triple procedure (open sky intrascleral intraocular lens fixation with double-needle and PKP) secondary to ocular trauma or a failed corneal transplant. Read More
Ann Surg Treat Res 2018 Dec 26;95(6):340-344. Epub 2018 Nov 26.
Department of Trauma, Gachon University Gil Medical Center, Incheon, Korea.
Purpose: Traumatic lumbar hernia is rare, thus making diagnosis and proper treatment challenging. Accordingly, we aimed to investigate the clinical manifestations and proper management strategies of traumatic lumbar hernias.
Methods: The medical records of patients with traumatic lumbar hernia treated at Gachon University Gil Hospital from March 2006 to February 2015, were retrospectively reviewed. Read More
Acta Pharm Sin B 2018 Oct 6;8(6):956-968. Epub 2018 Aug 6.
State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
In this paper, we prepared a dual functional system based on dextrin-coated silver nanoparticles which were further attached with iron oxide nanoparticles and cell penetrating peptide (Tat), producing Tat-modified Ag-FeO nanocomposites (Tat-FeAgNPs). To load drugs, an -SH containing linker, 3-mercaptopropanohydrazide, was designed and synthesized. It enabled the silver carriers to load and release doxorubicin (Dox) in a pH-sensitive pattern. Read More
Acta Pharm Sin B 2018 Oct 18;8(6):862-880. Epub 2018 May 18.
Department of Pharmacy, Integrated Research Institute of Pharmaceutical Sciences, and BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future Pharmacy, College of Pharmacy, The Catholic University of Korea, Gyeonggi-do 14662, Republic of Korea.
Mitochondrial targeting is a promising approach for solving current issues in clinical application of chemotherapy and diagnosis of several disorders. Here, we discuss direct conjugation of mitochondrial-targeting moieties to anticancer drugs, antioxidants and sensor molecules. Among them, the most widely applied mitochondrial targeting moiety is triphenylphosphonium (TPP), which is a delocalized cationic lipid that readily accumulates and penetrates through the mitochondrial membrane due to the highly negative mitochondrial membrane potential. Read More
Oman J Ophthalmol 2018 Sep-Dec;11(3):291-293
Department of Anatomic pathology, Hospital Provincial de Castellón, Castellón de la Plana, Castellón, Spain.
We describe a case of a man with neurotrophic keratitis of unknown ethiology, who developed a massive stromal melting during treatment of a persistent epithelial defect. A tectonic keratoplasty combined with amniotic membrane grafting was made. Host cornea specimen was analyzed, and Sphingomonas paucimobilis was isolated. Read More
Oman J Ophthalmol 2018 Sep-Dec;11(3):220-226
Department of Ophthalmology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Jolly Grant, Dehradun, Uttarakhand, India.
Background: Glaucoma is the leading cause of blindness after penetrating keratoplasty (PK) and its early diagnosis and management is mandatory to salvage the graft.
Aims: This study aimed to evaluate the incidence and risk factors for post penetrating keratoplasty glaucoma (PKG).
Methods: Data of 155 eyes of 155 patients were reviewed retrospectively who underwent PK from March 2013 to February 2016. Read More
Can J Ophthalmol 2018 Dec 9;53(6):580-587. Epub 2018 May 9.
Keenan Research Centre at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ont; Department of Ophthalmology and Vision Sciences, Faculty of Medicine, University of Toronto, Toronto, Ont; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ont; Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.. Electronic address:
Objective: To assess trends in surgical procedures and indications for all corneal transplants performed at the University of Toronto.
Design: Retrospective cross-sectional study.
Participants: One thousand one hundred and four consecutive corneal transplants performed at the Kensington Eye Institute (KEI). Read More
Can J Ophthalmol 2018 Dec 10;53(6):568-573. Epub 2018 Apr 10.
Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alta.. Electronic address:
Objective: To study indications for penetrating keratoplasty (PK) at a single site. The trends in the causative organisms for infectious keratitis requiring surgery were also evaluated.
Design: Retrospective observational study. Read More
J Surg Res 2019 Jan 22;233:453-458. Epub 2018 Sep 22.
Division of Trauma and Burns, Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington. Electronic address:
Background: Despite a proven record of identifying injuries missed during clinical evaluation, the effect of autopsy on injury severity score (ISS) calculation is unknown. We hypothesized that autopsy data would alter final ISS and improve the accuracy of outcome data analyses.
Materials And Methods: All trauma deaths from January 2010 through June 2014 were reviewed. Read More
Soc Neurosci 2018 Dec 3. Epub 2018 Dec 3.
b Cognitive Neuroscience Laboratory, Brain Injury Research , Shirley Ryan AbilityLab, Chicago , IL , USA.
Loneliness is perceived as social isolation and exclusion. The neural substrate of loneliness has been investigated with functional neuroimaging; however, lesion-based studies and their associated outcomes are needed to infer causal involvement between brain regions and function. Here, we applied voxel-based lesion-symptom mapping (VLSM) analyses to investigate the causal role of brain lesions on self-report of loneliness (UCLA Loneliness Scale) in a unique sample from the Vietnam Head Injury Study, including veterans with penetrating traumatic brain injuries (pTBI) (n = 132) and healthy controls (HCs) (n = 35). Read More
J Neurophysiol 2018 Dec 5. Epub 2018 Dec 5.
Scripps Research Institute, United States.
Traumatic brain injuries introduce functional and structural circuit deficits that must be repaired for an organism to regain function. We developed an injury model in which Xenopus laevis tadpoles are given a penetrating stab wound that damages the optic tectal circuit and impairs visuomotor behavior. In tadpoles, as in other systems, injury induces neurogenesis. Read More
Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):587-593
Department of Radiology, Dr. Aşkım Tüfekçi State Hospital, Adana-Turkey.
Background: The aim of this study was to investigate the characteristics of shrapnel distribution in the body and a possible relationship to the type of weapon and type of location of the conflict.
Methods: The records of 246 patients admitted to a level-III trauma center with any kind of firearm injury were examined retrospectively. Ninety patients who had at least 1 radiologically-proven piece of shrapnel in their body were included in the study. Read More
Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):563-568
Department of Ophthalmology, Ankara Training and Research Hospital, Ankara-Turkey.
Background: The purpose of this study was to investigate factors affecting wound dehiscence due to blunt trauma following penetrating keratoplasty (PK) and the clinical outcomes.
Methods: The medical records of patients who experienced blunt traumatic wound dehiscence after PK between 1995 and 2015 were analyzed retrospectively. The incidence and etiology of the trauma, the time interval between PK and globe rupture, final graft clarity, best-corrected visual acuity, complications, secondary surgeries, and factors potentially affecting wound dehiscence size were recorded. Read More
J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.
Hubei Key Lab of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, China.
Although gene therapy offers hope against incurable diseases, nonreplicating transduction vectors remain lacking. We have previously characterized a cell-penetrating peptide hPP10 for the delivery of various cargoes; however, whether hPP10 can mediate nucleic acid delivery is still unknown. Here, examining via different ways, we demonstrate that hPP10 stably complexes with plasmid DNA (pDNA) and safely mediates nucleic acid transfection. Read More
Rev Prat 2016 May;66(5):508-513
Institut du glaucome, hôpital Saint-Joseph, Paris, France.
Glaucomas treatment. Glaucoma is the first cause of blindness in Europe. The purposes of its treatment are lowering intraocular pressure (IOP), but also getting a good patient compliance with a good tolerance and a good ratio cost/effectiveness. Read More
Rev Prat 2016 Sep;66(7):799-803
Service de médecine physique et de réadaptation, Hôpital d'instruction des armées Percy, Clamart, France.
Rehabilitation after a war injury. Combat wounds can be the cause of serious physical and mental trauma. Injuries caused by the explosion of improvised devices are responsible for multiple penetrating injuries, limb amputations, brain or spinal-cord injuries, and sometimes severe burns. Read More
Phys Chem Chem Phys 2018 Dec 4. Epub 2018 Dec 4.
Institute of Macromolecular Compounds, Russian Academy of Sciences, Bolshoj pr. V.O., 31, 199004 St. Petersburg, Russia. and Department of Chemistry, The University of Western Ontario, 1151 Richmond St, London, N6A 5B7, Ontario, Canada. and Department of Applied Mathematics, The University of Western Ontario, 1151 Richmond St, London, N6A 5B7, Ontario, Canada.
Cellulose can be phosphorylated to produce organic matrices with highly adsorptive properties for, e.g., biocompatible materials for biomedical applications. Read More
Trauma Case Rep 2018 Dec 24;18:17-23. Epub 2018 Nov 24.
Nervous Diseases and Neurosurgery Department, Postgraduate Education Division, Dnipropetrovsk Medical Academy, The Ministry of Healthcare of Ukraine, Dnipro, Ukraine.
Successful step-by-step treatment of a combined gunshot shrapnel injury of the brain, damaging the left middle cerebral artery (MCA) branches, and penetrating myocardium injury is discussed. Open brain and heart surgeries were performed. A left MCA pseudoaneurysm was formed postoperatively. Read More
Cureus 2018 Sep 26;10(9):e3367. Epub 2018 Sep 26.
Interventional Radiology, University of Florida College of Medicine, Jacksonville, USA.
The incidence and prevalence of firearm-related homicide in the United States make headlines daily. As a result, an epidemic of penetrating injuries is on the rise. Specifically, foreign bodies such as bullets and shrapnel are usually left inside the human body due to penetrating injuries, unless they are in close proximity to vital structures. Read More
Cureus 2018 Jul 5;10(7):e2926. Epub 2018 Jul 5.
Gastroenterology, Mercy St. Vincent Medical Center, Toledo, USA.
A 33-year-old man was admitted to the hospital with upper abdominal pain and melena. Laboratory tests were suggestive of pancreatitis. Computed tomography (CT) of the abdomen showed peripancreatic fat stranding but showed no free air in the peritoneal cavity. Read More
Injury 2018 Nov 26. Epub 2018 Nov 26.
Chulalongkorn University, Surgery, Rama4 rd, Bangkok, Thailand.
Introduction: Abdominal vascular injuries (AVIs) remain a great challenge since they are associated with significant mortality. Penetrating injury is the most common cause of AVIs; however, some AVI series had more blunt injuries. There is little information regarding differences between penetrating and blunt AVIs. Read More
Arch Med Sadowej Kryminol 2018 ;68(2):79-95
This paper, as the third of the series, is devoted to gauge ammunition, which may be a problem in ballistic opinions. The paper reviews existing cartridges of the type used in smoothbore weapons (bullet cartridges, non-penetrating, compressed powder, flash-bang, signal, adapter-type, and training cartridges). The paper also presents homemade special cases of gauge ammunition, as well as ammunition used for "peculiar" purposes. Read More
World J Emerg Surg 2018 27;13:55. Epub 2018 Nov 27.
Division of Vascular and Endovascular Surgery, Department of Surgery, University of Ottawa, The Ottawa Hospital, Civic Campus, Room A280, 1053 Carling Avenue, Ottawa, Ontario K1Y 4E9 Canada.
Background: Although mandatory laparotomy has been standard of care for patients with abdominal gunshot wounds (GSWs) for decades, this approach is associated with non-therapeutic operations, morbidity, and long hospital stays. This systematic review and meta-analysis sought to summarize outcomes of selective nonoperative management (SNOM) of civilian abdominal GSWs.
Methods: We searched electronic databases (March 1966-April 1, 2017) and reference lists of articles included in the systematic review for studies reporting outcomes of SNOM of civilian abdominal GSWs. Read More
J AAPOS 2018 Nov 27. Epub 2018 Nov 27.
Royal Victorian Eye and Ear Hospital, Melbourne, Australia.
Purpose: To report outcomes of femtosecond-assisted single-piece mushroom keratoplasty for the treatment of full-thickness corneal disease in pediatric patients with healthy endothelium.
Methods: Femtosecond-assisted mushroom keratoplasty was performed in 8 eyes of 8 patients (age range, 8-17 years) with central full-thickness corneal opacity. The single-piece mushroom-shaped graft consisted of a large anterior portion (9 mm in diameter; 250 μm in thickness) and a small posterior portion (6-6. Read More
Ned Tijdschr Geneeskd 2018 Nov 29;162. Epub 2018 Nov 29.
Erasmus MC, Trauma Research Unit, afd. Heelkunde, Rotterdam.
Objective: To report the number of patients with firework-related injuries treated in December 2017 and January 2018 in a hospital in the south-west Netherlands trauma region, and to provide details about the types of firework used and the specific injuries.
Design: A prospective multicentre cohort study (NTR6793).
Methods: Patients of all ages with firework-related injuries were eligible for inclusion. Read More
Cornea 2018 Nov 27. Epub 2018 Nov 27.
Sussex Eye Hospital, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom.
Purpose: To review the outcome of 3 techniques for managing type 2 bubbles (between Descemet's membrane [DM] and stroma) formed during big bubble (BB) deep anterior lamellar keratoplasty (DALK) in different corneal pathologies.
Methods: This is an interventional case series study of patients with type 2 bubbles formed during BB DALK. Three techniques to complete DALK are described: the first is a DM baring technique similar to Anwar's BB technique, the second is the microbubble incision technique to preserve the pre-Descemetic support to DM, and the third is done in eyes with combined type 1 and type 2 BB (mixed bubble), where the type 1 bubble is opened and surgery is completed avoiding the type 2 bubble. Read More
Cornea 2018 Nov 28. Epub 2018 Nov 28.
Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan.
Purpose: To evaluate the effect of iris damage on endothelial cell loss in the early phase after penetrating keratoplasty (PKP).
Methods: This prospective consecutive study included 74 patients who underwent PKP without graft rejection during the follow-up period. Endothelial cell density (ECD) was measured using specular microscopy at 1, 3, 6, and 12 months after PKP. Read More
Dalton Trans 2018 Nov 30. Epub 2018 Nov 30.
The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou 510632, China.
Herein we designed and synthesized a cell penetrating peptide- and cancer-targeted molecule-functionalized multi-walled carbon nanotube for precise orthotopic glioma therapy. In addition to reduced toxicity, this nanosystem exhibited enhanced cancer recognition, blood-brain barrier (BBB) penetration, and anticancer activity through increased ROS production. Read More
Vestn Oftalmol 2018 ;134(5. Vyp. 2):238-243
Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.
Corneal transplantation is the most successful and frequently performed allotransplantation procedure. Benign outcome of penetrating and posterior keratoplasty depends on viability of the corneal tissue and presence of the proper endothelial layer, which retaining is one of the main objectives of preservation of donor material. Methods designed to reach this goal may be classified according to storage duration as short-term (storage in a moist chamber), medium-term (hypothermia), long-term (organ cultivation) and unlimited (cryopreservation). Read More
Curr Top Med Chem 2018 Nov 29. Epub 2018 Nov 29.
Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, 9401 Jeronimo Road, Irvine, California 92618-1908. United States.
The menace of multi-drug resistance by bacterial pathogens that are responsible for infectious diseases in humans and animals cannot be over-emphasized. Many bacteria develop resistance to antibiotics by one or more combination of resistance mechanisms namely, efflux pump activation thereby reducing bacteria intracellular antibiotic concentration, synthesizing a protein that protects target site causing poor antibiotic affinity to the binding site, or mutations in DNA and topoisomerase gene coding that alters residues in the binding sites. The ability to use a combination of these resistance mechanisms among others create a phenomenon known as antimicrobial drug resistance. Read More
Nano Converg 2018 Nov 30;5(1):35. Epub 2018 Nov 30.
Department of Mechanical Engineering and Engineering Science, Center for Biomedical Engineering and Science, Department of Biological Sciences, The Nanoscale Science Program, University of North Carolina at Charlotte, Charlotte, NC, USA.
The major neurological disorders found in a central nervous system (CNS), such as brain tumors, Alzheimer's diseases, Parkinson's diseases, and Huntington's disease, have led to devastating outcomes on the human public health. Of these disorders, early diagnostics remains poor, and no treatment has been successfully discovered; therefore, they become the most life-threatening medical burdens worldwide compared to other major diseases. The major obstacles for the drug discovery are the presence of a restrictive blood-brain barrier (BBB), limiting drug entry into brains and undesired neuroimmune activities caused by untargeted drugs, leading to irreversible neuronal damages. Read More
Mol Syst Des Eng 2017 Oct 16;2(4):370-379. Epub 2017 Aug 16.
Department of Medicine, Division of NanoMedicine, University of California, Los Angeles, CA, USA.
Many solid tumor types, such as pancreatic cancer, have a generally poor prognosis, in part because the delivery of therapeutic regimen is prohibited by pathological abnormalities that block access to tumor vasculature, leading to poor bioavailability. Recent development of tumor penetrating iRGD peptide that is covalently conjugated on nanocarriers' surface or co-administered with nanocarriers becomes a popular approach for tumor targeting. More importantly, scientists have unlocked an important tumor transcytosis mechanism by which drug carrying nanoparticles directly access solid tumors (without the need of leaky vasculature), thereby allowing systemically injected nanocarriers more abundantly distribute at tumor site with improved efficacy. Read More
J Vasc Surg Venous Lymphat Disord 2018 Nov 26. Epub 2018 Nov 26.
Division of Vascular Surgery, Department of Surgery, Advocate Illinois Masonic Medical Center, Chicago, Ill.
In this case, a 22-year-old man sustained multiple gunshot wounds to the abdomen, which required in extremis surgical exploration with damage control laparotomy and hemostatic resuscitation in the surgical intensive care unit. Diagnostic angiography was negative and an inferior vena cava (IVC) injury was suspected. He was returned to the operating room, where the infrarenal IVC was accessed by direct puncture and venography demonstrated active extravasation of the suprarenal vena cava. Read More