11,388 results match your criteria Pemphigus Vulgaris

Potential shared therapeutic and hepatotoxic mechanisms of Tripterygium wilfordii polyglycosides treating three kinds of autoimmune skin diseases by regulating IL-17 signaling pathway and Th17 cell differentiation.

J Ethnopharmacol 2022 Jun 21:115496. Epub 2022 Jun 21.

Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China. Electronic address:

Ethnopharmacological Relevance: Tripterygium wilfordii polyglycosides (TWP) are extracted from Tripterygium wilfordii Hook. f., which has the significant effects of anti-inflammation and immunosuppression and has been widely used to treat autoimmune diseases in traditional Chinese medicine. Read More

View Article and Full-Text PDF

Oral Health, Antimicrobials and Care for Patients With Chronic Oral Diseases - A Review of Knowledge and Treatment Strategies.

Front Oral Health 2022 7;3:866695. Epub 2022 Jun 7.

Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, United Kingdom.

Periodontal and chronic oral mucosal diseases are significant life impacting conditions which may co-exist and synergistically act to cause more severe and widespread oral pathology with enhanced challenges in effective management. Clinicians regularly observe these effects and struggle to effectively manage both problems in many patients. There is limited understanding of many basic and applied scientific elements underpinning potentially shared aetiopathological features and management. Read More

View Article and Full-Text PDF

Current and Innovated Managements for Autoimmune Bullous Skin Disorders: An Overview.

J Clin Med 2022 Jun 19;11(12). Epub 2022 Jun 19.

Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.

Autoimmune bullous skin disorders are a group of disorders characterized by the formation of numerous blisters and erosions on the skin and/or the mucosal membrane, arising from autoantibodies against the intercellular adhesion molecules and the structural proteins. They can be classified into intraepithelial or subepithelial autoimmune bullous dermatoses based on the location of the targeted antigens. These dermatoses are extremely debilitating and fatal in certain cases, depending on the degree of cutaneous and mucosal involvement. Read More

View Article and Full-Text PDF

Assessment of Immune Cell Activation in Pemphigus.

Cells 2022 Jun 13;11(12). Epub 2022 Jun 13.

Department of Biochemical Diagnostics, Chair of Laboratory Diagnostics, Medical University of Lublin, 20-081 Lublin, Poland.

(1) Background: Pemphigus is a blistering autoimmune disease of the skin and/or mucous membranes, characterised by the presence of specific autoantibodies directed against structural proteins of the human skin. Recent reports indicate that new haematological parameters, termed Extended Inflammation Parameters (EIP), can be used to assess the activation of immune cells during active inflammation. These include parameters assessing both neutrophil activation (NEUT-RI, NEUT-GI) and the number of activated lymphocytes (RE-LYMP). Read More

View Article and Full-Text PDF

Assessing the use of methotrexate as an alternate therapy for pemphigus vulgaris and pemphigus foliaceus.

Dermatol Ther 2022 Jun 23:e15661. Epub 2022 Jun 23.

The Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York.

Background: Methotrexate is historically recognized as an effective treatment of pemphigus but its utility as a single or alternate steroid-sparing agent was not recognized in recent consensus recommendations in pemphigus management.

Objectives: To evaluate the efficacy and safety of a treatment course for pemphigus that involves methotrexate as a single or steroid-sparing agent.

Methods: In a retrospective cohort study, we examined patients with pemphigus vulgaris or pemphigus foliaceus who were on ≥ three months of methotrexate therapy. Read More

View Article and Full-Text PDF

Dupilumab in Hailey-Hailey disease: A case series.

J Eur Acad Dermatol Venereol 2022 Jun 23. Epub 2022 Jun 23.

Department of Dermatology1, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.

View Article and Full-Text PDF

Cutaneous-type pemphigus vulgaris might be a transient subtype in pemphigus vulgaris: a case series.

J Eur Acad Dermatol Venereol 2022 Jun 22. Epub 2022 Jun 22.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

View Article and Full-Text PDF

Evaluation of Clinical Relevance and Biological Effects of Antirituximab Antibodies in Patients With Pemphigus.

JAMA Dermatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Dermatology, Normandie University, Université de Rouen, Inserm U1234, CHU Rouen, Rouen, France.

Importance: The clinical relevance of antirituximab antibodies (ARAs) in patients with pemphigus who are treated with rituximab (RTX) is currently unknown.

Objective: To determine the prevalence of ARAs in patients with pemphigus who are treated with RTX and their association with complete remission (CR) and relapse.

Design, Setting, And Participants: This post hoc analysis of the Ritux3 trial was conducted from January 2010 to December 2015 in 25 dermatology departments in France and included 42 patients with moderate-to-severe pemphigus who were randomized to receive treatment with RTX. Read More

View Article and Full-Text PDF

Mechanisms Causing Acantholysis in Pemphigus-Lessons from Human Skin.

Front Immunol 2022 20;13:884067. Epub 2022 May 20.

Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilians-Universität Munich, Munich, Germany.

Pemphigus vulgaris (PV) is an autoimmune bullous skin disease caused primarily by autoantibodies (PV-IgG) against the desmosomal adhesion proteins desmoglein (Dsg)1 and Dsg3. PV patient lesions are characterized by flaccid blisters and ultrastructurally by defined hallmarks including a reduction in desmosome number and size, formation of split desmosomes, as well as uncoupling of keratin filaments from desmosomes. The pathophysiology underlying the disease is known to involve several intracellular signaling pathways downstream of PV-IgG binding. Read More

View Article and Full-Text PDF

Distinct metabolite profile in pemphigus vulgaris.

J Invest Dermatol 2022 Jun 16. Epub 2022 Jun 16.

Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany.

View Article and Full-Text PDF

A literature review on Janus kinase (JAK) inhibitors for the treatment of immunobullous disorders.

Int Immunopharmacol 2022 Jun 16;110:108923. Epub 2022 Jun 16.

Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Janus kinases (JAKs) are a group of intracytoplasmic tyrosine kinase proteins that bind to the cytoplasmic part of the transmembrane cytokine receptors and regulate signaling. The pathophysiology of various autoimmune and autoinflammatory conditions relies on JAK/STAT signaling and therefore, the inhibition of JAK/STAT pathways can be a promising treatment for such diseases, especially inflammatory skin conditions. The current study aimed to evaluate the efficacy of JAK inhibitors in the treatment of immunobullous diseases, including pemphigus, pemphigoid, dermatitis herpetiformis, and epidermolysis bullosa. Read More

View Article and Full-Text PDF

Cutaneous manifestations following COVID-19 vaccination: A report of 25 cases.

Dermatol Ther 2022 Jun 18:e15651. Epub 2022 Jun 18.

Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Various adverse effects particularly cutaneous manifestations associated with different COVID-19 vaccines have been observed in practice.

Aim: To evaluate all patients who presented to our tertiary center with skin manifestations following COVID-19 vaccines injection from September to December 2021.

Method: All patients with skin manifestation within 30 days or less following COVID-19 vaccination were enrolled in our case-series. Read More

View Article and Full-Text PDF

Omalizumab as Adjuvant Therapy for Pemphigus Vulgaris.

Dermatol Ther 2022 Jun 18:e15646. Epub 2022 Jun 18.

Department of Dermatology, University of California, Davis, Sacramento, California, USA.

View Article and Full-Text PDF

Dsg1 and Dsg3 Composition of Desmosomes Across Human Epidermis and Alterations in Pemphigus Vulgaris Patient Skin.

Front Immunol 2022 25;13:884241. Epub 2022 May 25.

Chair of Vegetative Anatomy, Instiute of Anatomy, Faculty of Medicine, Ludwig-Maximilian-Universität München (LMU) Munich, München, Germany.

Desmosomes are important epidermal adhesion units and signalling hubs, which play an important role in pemphigus pathogenesis. Different expression patterns of the pemphigus autoantigens desmoglein (Dsg)1 and Dsg3 across different epidermal layers have been demonstrated. However, little is known about changes in desmosome composition in different epidermal layers or in patient skin. Read More

View Article and Full-Text PDF

A Case of Pemphigus Vulgaris and Hidradenitis Suppurativa: May Systemic Steroids Be Considered in the Standard Management of Hidradenitis Suppurativa?

Skin Appendage Disord 2022 May 26;8(3):265-268. Epub 2022 Jan 26.

Department of Clinical Medicine and Surgery, Section of Dermatology, University Hospital Federico II of Naples, Naples, Italy.

Introduction: Recent studies have demonstrated a correlation between pemphigus and hidradenitis suppurativa (HS).

Case Presentation: Here, we report the case of a 58-year-old man affected by HS for about 30 years who was found to have lesions attributable to pemphigus during a checkup.

Discussion/conclusion: There are few data in the literature on the use of systemic corticosteroids for the two diseases, and our article wants to be a food for thought on the management and treatment of these diseases. Read More

View Article and Full-Text PDF

From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus.

Front Immunol 2022 27;13:907424. Epub 2022 May 27.

Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

In the endemic variants of pemphigus foliaceus (PF), in Brazil and Tunisia, patients generate pathogenic IgG4 anti-desmoglein 1 autoantibodies. Additionally, these patients possess antibodies against salivary proteins from sand flies that react with Dsg1, which may lead to skin disease in susceptible individuals living in endemic areas. This minireview focuses on recent studies highlighting the possible role of salivary proteins from () in EPF from Brazil and () in EPF from Tunisia. Read More

View Article and Full-Text PDF

Phase 2 BELIEVE study part B: Efficacy and safety of rilzabrutinib for patients with pemphigus vulgaris.

J Eur Acad Dermatol Venereol 2022 Jun 10. Epub 2022 Jun 10.

Department of Dermatology, Rouen University Hospital, Centre de Référence des Maladies Bulleuses Autoimmunes, and INSERM U1234, Normandie University, Rouen, France.

View Article and Full-Text PDF

Reply to 'Development of severe pemphigus vulgaris following SARS-CoV-2 vaccination with BNT162b2' by Solimani et al.

J Eur Acad Dermatol Venereol 2022 Jun 9. Epub 2022 Jun 9.

Dermatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

View Article and Full-Text PDF

How to decrease systemic corticosteroids in pemphigus patients under rituximab.

Health Sci Rep 2022 Jul 6;5(4):e639. Epub 2022 Jun 6.

Dermatology Unit, Department of Clinical Medicine and Surgery University of Naples Federico II Naples Italy.

View Article and Full-Text PDF

Germinal Center-Related G Protein-Coupled Receptors in Antibody-Mediated Autoimmune Skin Diseases: from Basic Research to Clinical Trials.

Clin Rev Allergy Immunol 2022 Jun 8. Epub 2022 Jun 8.

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 12 Jiangwangmiao Street, Nanjing, 210042, China.

Germinal center (GC) reaction greatly contributes to the humoral immune response, which begins in lymph nodes or other secondary lymphoid organs after follicular B cells are activated by T-dependent antigens. The GCs then serve as a platform for follicular B cells to complete clonal expansion and somatic hypermutation and then interact with follicular dendritic cells (FDC) and follicular helper T cells (Tfh). Through the interaction between the immune cells, significant processes of the humoral immune response are accomplished, such as antibody affinity maturation, class switching, and production of memory B cells and plasma cells. Read More

View Article and Full-Text PDF

Belimumab for the Treatment of Pemphigus.

Dermatol Ther 2022 Jun 7:e15621. Epub 2022 Jun 7.

Dermatology Department, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

View Article and Full-Text PDF

Trunk-dominant and classic facial pemphigus foliaceus in dogs - comparison of anti-desmocollin-1 and anti-desmoglein-1 autoantibodies and clinical presentations.

Vet Dermatol 2022 Jun 7. Epub 2022 Jun 7.

Department of Clinical Sciences, College of Veterinary Medicine, NC State University, Raleigh, NC, USA.

Background: Canine trunk-dominant pemphigus foliaceus (PF) is mentioned rarely in the literature.

Hypothesis/objectives: The goal of this study was to provide clinical description of trunk-dominant PF and to demonstrate the prevalence of serum antikeratinocyte, anti-desmocollin-1 (DSC1) and anti-desmoglein-1 (DSG1) antibodies, and determine their diagnostic value in this particular PF phenotype.

Materials And Methods: Clinically relevant information was collected from 31, 25 and 34 dogs with trunk-dominant and facial PF and superficial pyoderma (SP), respectively. Read More

View Article and Full-Text PDF

A case of anti-laminin gamma-1 (p200) pemphigoid with bullous lesions on the lips, hands and feet showing antibodies to desmoglein 1.

Skin Health Dis 2022 Mar 11;2(1):e101. Epub 2022 Feb 11.

Dermatology Unit Southern TOHOKU General Hospital Southern TOHOKU Research Institute for Neuroscience Koriyama Japan.

An 87-years-old-man presented with bullous and erosive lesions exclusively on the lips, hands and feet. Histopathological and direct immunofluorescence studies suggested the diagnosis of bullous pemphigoid, but the serum anti-BP180 antibodies were negative. Strangely, anti-desmoglein 1 antibodies were positive, although no pemphigus-like features were found. Read More

View Article and Full-Text PDF

FcRn Antagonism Leads to a Decrease of Desmoglein-Specific B Cells: Secondary Analysis of a Phase 2 Study of Efgartigimod in Pemphigus Vulgaris and Pemphigus Foliaceus.

Front Immunol 2022 18;13:863095. Epub 2022 May 18.

INSERM U1234, Normandie University, Rouen, France.

Background: Immunoglobulin G (IgG) levels are maintained by the IgG-recycling neonatal Fc-receptor (FcRn). Pemphigus vulgaris and pemphigus foliaceus are debilitating autoimmune disorders triggered by IgG autoantibodies against mucosal and epidermal desmogleins. Recently, a phase 2 clinical trial (NCT03334058; https://clinicaltrials. Read More

View Article and Full-Text PDF

New-onset pemphigus foliaceus following SARS-CoV-2 infection and unmasking multiple sclerosis: A case report.

Clin Case Rep 2022 Jun 3;10(6):e05910. Epub 2022 Jun 3.

Clinical Research Development Center Imam Reza Hospital Kermanshah University of Medical Sciences Kermanshah Iran.

Development of pemphigus foliaceus (PF) following SARS-CoV-2 infection has only been reported in one patient who had received Bamlanivimab and thus might be considered as a drug-induced case of PF. Here, we reported the first case of PF arising solely after COVID infection without taking any culprit drug. Read More

View Article and Full-Text PDF

[A Case of Pemphigus Vulgaris Showing a Local Nose Erosion as the First Clinical Manifestation].

J UOEH 2022 ;44(2):215-219

Department of Dermatology, University of Occupational and Environmental Health, Japan.

A 73-year-old male noticed a localized nose erosion that we thought was possibly an exacerbation of skin erosion due to the direct influence of friction from wearing a mask. Blood examination revealed a remarkable increase in serum anti-desmoglein-1 and anti-desmoglein-3 antibodies. A skin biopsy showed acantholysis in the epidermal granular layer. Read More

View Article and Full-Text PDF

A systematic review and meta-analysis of HLA class II associations in patients with IgG4 autoimmunity.

Sci Rep 2022 Jun 2;12(1):9229. Epub 2022 Jun 2.

Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria.

Autoimmune diseases caused by pathogenic IgG4 subclass autoantibodies (IgG4-AID) include diseases like MuSK myasthenia gravis, pemphigus vulgaris or thrombotic thrombocytopenic purpura. Their etiology is still unknown. Polymorphisms in the human leukocyte antigen (HLA) gene locus, particularly in HLA-DRB1, are known genetic susceptibility factors for autoimmune diseases. Read More

View Article and Full-Text PDF

Localized CO2 Laser Treatment of a Recalcitrant Oral Ulceration in Pemphigus Vulgaris.

Clin Adv Periodontics 2022 Jun 1. Epub 2022 Jun 1.

Associate Professor of Dermatology, Stanford University, Stanford, CA.

Introduction: Recalcitrant oral lesions of pemphigus vulgaris (PV), an autoimmune blistering disease, can result in significant discomfort, difficulty eating and maintaining oral hygiene. Increasing the dosage of systemic medications to control such localized lesions result in increased risk of adverse-effects.

Case Presentation: We describe a male patient diagnosed at age 51 with PV by oral biopsy that included a direct immunofluorescence examination. Read More

View Article and Full-Text PDF

Serological Biomarkers and Their Detection in Autoimmune Bullous Skin Diseases.

Dermatol Pract Concept 2022 May 1;12(2):e2022116. Epub 2022 Apr 1.

EUROIMMUN US Inc, 1 Bloomfield Ave, Mountain Lakes, New Jersey, United States.

Autoimmune bullous diseases (AIBDs) are a group of skin-related disorders that involve damage to structures maintaining cell-cell adhesion, such as desmosomes and hemidesmosomes. Key AIBDs include pemphigus related diseases, pemphigoid related conditions, acquired epidermolysis bullosa (EBA), and dermatitis herpetiformis (DH). Each group of conditions exhibits characteristic clinical lesion patterns and is associated with specific autoantibodies targeting epidermal and dermal structures involved in cell-cell adhesion and skin integrity. Read More

View Article and Full-Text PDF