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    Association Between Pemphigus and Neurologic Diseases.
    JAMA Dermatol 2018 Feb 16. Epub 2018 Feb 16.
    Department of Quality Measurements and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel.
    Importance: The association between pemphigus and neurologic diseases was not evaluated systematically in the past. In a recent uncontrolled cross-sectional study, Parkinson disease was found to be significantly associated with pemphigus; in the same study, epilepsy had a nonsignificant association with pemphigus. Several case reports have suggested that pemphigus coexists with multiple sclerosis and dementia. Read More

    Coexistent Solid Malignancies in Pemphigus: A Population-Based Study.
    JAMA Dermatol 2018 Feb 16. Epub 2018 Feb 16.
    Department of Quality Measurements and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel.
    Importance: The association of pemphigus vulgaris and pemphigus foliaceus with comorbid malignancies is yet to be firmly established.

    Objective: To estimate the association between pemphigus and a wide range of nonhematologic malignancies using one of the largest cohorts of patients with pemphigus to date.

    Design, Setting, And Participants: For this cross-sectional study, we used the computerized database of Clalit Health Services, the largest public health care provider organization in Israel insuring 4. Read More

    Pemphigus-A Disease of Desmosome Dysfunction Caused by Multiple Mechanisms.
    Front Immunol 2018 1;9:136. Epub 2018 Feb 1.
    Faculty of Medicine, Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany.
    Pemphigus is a severe autoimmune-blistering disease of the skin and mucous membranes caused by autoantibodies reducing desmosomal adhesion between epithelial cells. Autoantibodies against the desmosomal cadherins desmogleins (Dsgs) 1 and 3 as well as desmocollin 3 were shown to be pathogenic, whereas the role of other antibodies is unclear. Dsg3 interactions can be directly reduced by specific autoantibodies. Read More

    Paraneoplastic Pemphigus in a 34-year-old.
    Dermatol Online J 2017 Dec 15;23(12). Epub 2017 Dec 15.
    New York University Health, New York.
    Paraneoplastic Pemphigus (PNP) is a rare and often fatal autoimmune mucocutaneous blistering disease associated with an underlying malignancy. It is thought to be caused by antibodies to tumor antigenscross-reacting with epithelial antigens, specifically desmosomal and hemidesmosomal antigens. There are at least five clinical morphologic variants of PNP, with the earliest and most consistent finding beingsevere stomatitis. Read More

    Rituximab and intravenous immunoglobulin as alternatives to long-term systemic corticosteroids in the treatment of pemphigus: a single center case series of 63 patients.
    Dermatol Online J 2018 Jan 19;23(12). Epub 2018 Jan 19.
    Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.
    Rituximab and intravenous immunoglobulin [IVIg] have recently emerged as effective treatments for pemphigus refractory to corticosteroids [CS]. This case series sought to compare the clinical, serologic,and adverse effects of CS, IVIg, and rituximab in patients with pemphigus. A retrospective review of 63 patients with pemphigus vulgaris (PV), pemphigus foliaceus (PF), or paraneoplastic pemphigus (PNP)was performed. Read More

    Association of pemphigus and systemic corticosteroid use with comorbid health disorders: A case-control study.
    Dermatol Online J 2017 Dec 15;23(12). Epub 2017 Dec 15.
    Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
    Background: Pemphigus is a group of debilitating autoimmune blistering disorders associated with painful blisters of the skin and/or mucous membranes. Identification and management of the comorbiditiesof pemphigus is critically important to minimize morbidity and decrease mortality.

    Objective: To identify the comorbid health conditions of pemphigus vulgaris. Read More

    Patients affected by endemic pemphigus foliaceus in Colombia, South America exhibit autoantibodies to optic nerve sheath envelope cell junctions.
    Dermatol Pract Concept 2018 Jan 31;8(1):1-6. Epub 2018 Jan 31.
    Georgia Dermatopathology Associates, Atlanta, GA, USA.
    Background: The majority of the patients affected by a new variant of endemic pemphigus foliaceus in El Bagre, Colombia (El Bagre EPF or pemphigus Abreu-Manu), have experienced vision problems; we have previously reported several ocular abnormalities.

    Methods: Here, we aimed to investigate reactivity to optic nerves in these patients. We utilized bovine, rat and mouse optic nerves, and performed immunofluorescence and confocal microscopy to test for optical nerve autoreactivity. Read More

    Diagnosis and Management of Pemphigus: recommendations by an International Panel of Experts.
    J Am Acad Dermatol 2018 Feb 10. Epub 2018 Feb 10.
    Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA; Department of Dermatology at the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:
    Background: Several European countries recently developed international diagnostic and management guidelines for pemphigus, which have been instrumental in the standardization of pemphigus management, OBJECTIVE: We now present results from a subsequent Delphi consensus to broaden the generalizability of recommendations.

    Methods: A preliminary survey, based on the European Dermatology Forum (EDF) and the European Academy of Dermatology and Venereology (EADV) guidelines, was sent to a panel of international experts to determine the level of consensus. The results were discussed at the International Bullous Diseases Consensus Group in March 2016 during the annual American Academy of Dermatology (AAD) conference. Read More

    A case of pemphigus vulgaris associated with ulcerative colitis.
    Intest Res 2018 Jan 18;16(1):147-150. Epub 2018 Jan 18.
    Department of Pathology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
    Pemphigus vulgaris is an autoimmune bullous disorder characterized by the production of autoantibodies against the intercellular space of the epithelium. It has rarely been reported in association with inflammatory bowel disease. Ulcerative colitis is one of the forms of inflammatory bowel disease. Read More

    A prospective study comparing patients with early and late relapsing pemphigus treated with rituximab.
    J Am Acad Dermatol 2018 Jan 30. Epub 2018 Jan 30.
    Dermatology department Cairo University. Electronic address:
    Background: Rituximab (RTX) is an effective therapy for patients with pemphigus. However it does not prevent relapse.

    Objectives: To compare early relapsing patients (before 12 months) and late relapsing patients (after 24 months) following RTX therapy. Read More

    Treatment of Autoimmune Bullous Disorders in Pregnancy.
    Am J Clin Dermatol 2018 Feb 2. Epub 2018 Feb 2.
    Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA.
    Autoimmune bullous diseases (AIBD), including pemphigus, bullous pemphigoid, epidermolysis bullosa acquisita, mucous membrane pemphigoid, and pemphigoid gestationis, pose significant therapeutic challenges, especially in pregnant and post-partum breastfeeding patients or those planning to conceive. Data on the safety and efficacy of therapeutic interventions during the perinatal period are lacking because randomized controlled trials are typically not performed in this setting. However, many of the treatments for AIBD are also used in other diseases, so data can be extrapolated from studies or case reports in these other patient populations. Read More

    Gene Expression Analysis Reveals Novel Shared Gene Signatures and Candidate Molecular Mechanisms between Pemphigus and Systemic Lupus Erythematosus in CD4T Cells.
    Front Immunol 2017 17;8:1992. Epub 2018 Jan 17.
    Department of Dermatology, University of Lübeck, Lübeck, Germany.
    Pemphigus and systemic lupus erythematosus (SLE) are severe potentially life-threatening autoimmune diseases. They are classified as B-cell-mediated autoimmune diseases, both depending on autoreactive CD4T lymphocytes to modulate the autoimmune B-cell response. Despite the reported association of pemphigus and SLE, the molecular mechanisms underlying their comorbidity remain unknown. Read More

    Diagnostic patterns and delays in autoimmune blistering diseases of the mouth; a cross-sectional study.
    Oral Dis 2018 Jan 30. Epub 2018 Jan 30.
    Department of Oral and Maxillofacial Surgery Oral Medicine, and Periodontics School of Dentistry, The University of Jordan.
    Objectives: To describe the natural history and factors influencing diagnostic delays among patients with autoimmune blistering diseases of the mouth.

    Materials And Methods: In this cross-sectional study, 27 newly diagnosed patients were interviewed, and professional and patient delays were calculated. Disease extent and severity scores were determined using Saraswat scoring system. Read More

    Intravenous immunoglobulin treatment abrogates transplacental autoantibody transfer in a murine pemphigus model.
    J Allergy Clin Immunol 2018 Jan 19. Epub 2018 Jan 19.
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore. Electronic address:

    Reflectance confocal microscopy and optical coherence tomography for the diagnosis of bullous pemphigoid and pemphigus and surrounding sub-clinical lesions.
    J Eur Acad Dermatol Venereol 2018 Jan 16. Epub 2018 Jan 16.
    Dermatology Unit Surgical Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
    Background: Diagnosis of bullous pemphigoid (BP) and pemphigus is based on clinical features, histology, immunofluorescence and laboratory data.

    Objectives: To evaluate features of BP and pemphigus at reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) in order to provide a rapid non-invasive bed-side diagnosis. Secondary objective was to evaluate the detectability of clinically non-visible lesions. Read More

    A Case of Concomitant Pemphigus Foliaceus and Oral Pemphigus Vulgaris.
    Head Neck Pathol 2018 Jan 16. Epub 2018 Jan 16.
    Oral Medicine Unit, Charles Clifford Dental Hospital, 76 Wellesley Road, Sheffield, S10 2SZ, UK.
    Pemphigus is a chronic autoimmune condition that can affect multiple areas of the body. The two main subtypes of pemphigus are pemphigus vulgaris (PV) and pemphigus foliaceus (PF) which can rarely occur concurrently or even transition from one to the other. The process of transition may be explained by qualitative changes in desmoglein autoantibody profile. Read More

    Nail changes in autoimmune blistering disorders: A case-control study.
    Indian J Dermatol Venereol Leprol 2018 Jan 12. Epub 2018 Jan 12.
    Department of Dermatology, Venereology and Leprosy, Yenepoya Medical College, Yenepoya University, Mangalore, Karnataka, India.
    Background: Pemphigus and pemphigoid disorders produce blistering cutaneous lesions. Earlier case reports state that nail involvement is uncommon in these autoimmune blistering disorders.

    Aims And Objectives: To study nail changes in autoimmune blistering disorders. Read More

    [Paraneoplasms of the skin].
    Internist (Berl) 2018 Feb;59(2):134-144
    Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München, Ludwig-Maximilians-Universität München, München, Deutschland.
    The cutaneous manifestations of malignancies include nonmalignant skin disorders that occur in association with malignancies (facultative paraneoplastic dermatoses) and skin disorders that are always associated with hematologic diseases or solid tumors (obligate paraneoplastic dermatoses). Paraneoplastic increase of growth factors or immunological reactions lead to a variety of inflammatory, hyperkeratotic or proliferative skin reactions. When paraneoplastic dermatoses develop before cancer is diagnosed, recognition of these skin diseases can accelerate both the diagnosis and treatment. Read More

    A rare presentation of congenital syphilis: Pemphigus syphiliticus in a newborn infant with extensive desquamation of the extremities.
    Pediatr Dermatol 2018 Jan 4. Epub 2018 Jan 4.
    Department of Dermatology, University of California, Davis, Sacramento, CA, USA.
    Congenital syphilis is an infection transmitted from mother to fetus and can present with early but variable cutaneous manifestations. In rare situations, a bullous eruption known as pemphigus syphiliticus may develop. We present an unusual case of broad desquamation of the extremities in a newborn infant who was found to have congenital syphilis. Read More

    Pemphigus: a Comprehensive Review on Pathogenesis, Clinical Presentation and Novel Therapeutic Approaches.
    Clin Rev Allergy Immunol 2018 Feb;54(1):1-25
    Department of Dermatology and Allergology, Philipps-University, Baldingerstraße, D-35043, Marburg, Germany.
    Pemphigus is a group of rare, potentially devastating autoimmune diseases of the skin and mucous membranes with high morbidity and potentially lethal outcome. The major clinical variant, pemphigus vulgaris (PV) is caused by a loss of intercellular adhesion of epidermal keratinocytes which is induced by IgG autoantibodies against components of desmosomes. Specifically, IgG against the desmosomal adhesion proteins, desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1), preferentially target their ectodomains which are presumably critical for the transinteraction and signalling function of these adhesion molecules. Read More

    Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope.
    J Autoimmun 2018 Jan 4. Epub 2018 Jan 4.
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:
    Fogo Selvagem (FS), the endemic form of pemphigus foliaceus, is mediated by pathogenic IgG4 autoantibodies against the amino-terminal extracellular cadherin domain of the desmosomal cadherin desmoglein 1 (Dsg1). Here we define the detailed epitopes of these pathogenic antibodies. Proteolytic footprinting showed that IgG4 from 95% of FS donor sera (19/20) recognized a 16-residue peptide (ALNSMGQDLERPLELR) from the EC1 domain of Dsg1 that overlaps the binding site for an adhesive-partner desmosomal cadherin molecule. Read More

    Langerhans Cells Prevent Autoimmunity via Expansion of Keratinocyte Antigen-Specific Regulatory T Cells.
    EBioMedicine 2018 Jan 20;27:293-303. Epub 2017 Dec 20.
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:
    Langerhans cells (LCs) are antigen-presenting cells in the epidermis whose roles in antigen-specific immune regulation remain incompletely understood. Desmoglein 3 (Dsg3) is a keratinocyte cell-cell adhesion molecule critical for epidermal integrity and an autoantigen in the autoimmune blistering disease pemphigus. Although antibody-mediated disease mechanisms in pemphigus are extensively characterized, the T cell aspect of this autoimmune disease still remains poorly understood. Read More

    A review on botanicals with wound healing activity for pemphigus vulgarisperspective of traditional Persian medicine and conventional medicine.
    Avicenna J Phytomed 2017 Nov-Dec;7(6):486-494
    Department of Traditional Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
    Objective: As a rare autoimmune disease, pemphigus vulgaris has a poor prognosis especially in lack of proper medical support. This blistering disease involves both the skin and mucus membranes. The challenge is improving the healing process of skin lesions of which, superimposed infections are among the main causes of the disease mortality. Read More

    An Oral Disease Severity Score (ODSS) validated for use in oral pemphigus vulgaris.
    Br J Dermatol 2018 Jan 3. Epub 2018 Jan 3.
    Department Oral Medicine, Dental Institute Guy's and St Thomas NHS Foundation Trust and King's College London, London, UK.
    Objectives: The primary aim of this study was to validate the Oral Disease Severity Score (ODSS) for the assessment of oral involvement in pemphigus vulgaris (PV). A secondary aim was to compare the inter - intra- observer variability and ease of use with the Physician's Global Assessment (PGA) and the oral scoring methods used in Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and the Pemphigus Disease Area Index (PDAI).

    Methods: 15 patients with mild to moderately severe oral PV were scored for disease severity by 10 oral medicine clinicians using the ODSS, PGA and the oral sections of ABSIS and PDAI. Read More

    Direct Immunofluorescence as a Helpful Tool for the Differential Diagnosis of Oral Lichen Planus and Oral Lichenoid Lesions.
    Am J Dermatopathol 2017 Dec 28. Epub 2017 Dec 28.
    Department of Stomatology, Public Oral Health and Forensic Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
    A great number of lichenoid lesions have overlapping clinicopathological features, so the use of adjunct tests to establish definitive diagnosis is recommended for correct management and prognosis of the lesions. In this context, direct immunofluorescence (DIF) can be a useful tool. Thus, this study aimed to characterize the clinical, histopathological, and DIF pattern in patients with oral lichen planus (OLP) and patients with oral lichenoid lesions (OLLs). Read More

    Is Myc an Important Biomarker? Myc Expression in Immune Disorders and Cancer.
    Am J Med Sci 2018 Jan 15;355(1):67-75. Epub 2017 Jun 15.
    Department of Bone Marrow Transplantation (YA), Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
    The proto-oncogene Myc serves as a paradigm for understanding the dynamics of transcriptional regulation. Myc protein has been linked to immune dysfunction, cancer development and neoplastic transformation. We review recent research regarding functions of Myc as an important modulator in immune disorders, postallogeneic hematopoietic stem cell transplantation (HSCT) and several cancers. Read More

    [Humoral immune diseases: Cutaneous vasculitis and auto-immune bullous dermatoses].
    Ann Pathol 2018 Feb 27;38(1):31-42. Epub 2017 Dec 27.
    Département de pathologie, service d'anatomie et de cytologie pathologiques, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address:
    Humoral immunity is the cause of multiple diseases related to antibodies (IgA, IgG, IgM) produced by the patient. Two groups of diseases are identified. The first group is related to circulating antigen-antibody complexes. Read More

    Cutaneous Mucormycosis: A Fatal Complication of Immunosuppressant Therapy for Pemphigus Vulgaris.
    Skinmed 2017 1;15(6):467-469. Epub 2017 Dec 1.
    Department of Histopathology, Postgraduate nstitution of Medical Education and Research, Chandigarh, India.
    A 62-year-old man with no comorbidities presented to the outpatient department of our Institute with a history of extensive vesiculobullous and erosive skin lesions and oral erosions for 2 months and fever for 1 week. A diagnosis of pemphigus vulgaris was made based on histopathology and direct immunofluorescence of a skin biopsy specimen, and the patient was started on oral prednisolone 40 mg per day along with intravenous antibiotics (amoxicillin-clavulanic acid, gentamicin, and metronidazole) empirically, pending blood and skin swab culture and sensitivity reports. His biochemical and hematologic investigations revealed no abnormalities (hemoglobin 12. Read More

    A novel lateral flow immunoassay for the rapid detection of anti-Dsg3 IgG serum autoantibodies in pemphigus vulgaris.
    Exp Dermatol 2017 Dec 26. Epub 2017 Dec 26.
    Department of Dermatology and Allergology, Philipps-University, Marburg, Germany.
    Pemphigus vulgaris (PV) is a severe autoimmune blistering disease of the skin and mucous membranes. As autoantibodies play an essential role in the disease pathogenesis, the serological detection of anti-desmoglein 3 IgG represents a central tool in the diagnosis of the disease. In this study, we show the validation of a novel lateral flow immunoassay (LFIA) which rapidly detects anti-desmoglein 3 (Dsg3) IgG in human serum. Read More

    Cardiac rhythm and pacemaking abnormalities in patients affected by endemic pemphigus in Colombia may be the result of deposition of autoantibodies, complement, fibrinogen, and other molecules.
    Heart Rhythm 2017 Dec 24. Epub 2017 Dec 24.
    Department of Cardiology, Hospital General de Medellin, and Clinica CES Medellin, Antioquia, Colombia.
    Background: We previously showed that one-third of patients affected by endemic pemphigus foliaceus in El Bagre, Colombia (El Bagre-EPF), display autoreactivity to the heart.

    Objective: The purpose of this study was to investigate rhythm disturbances with the presence of autoantibodies and correlate them with ECG changes in these patients.

    Methods: We performed a study comparing 30 patients and 30 controls from the endemic area, matched by demographics, including age, sex, weight, work activities, and comorbidities. Read More

    Chickenpox: an ageless disease.
    BMJ Case Rep 2017 Dec 22;2017. Epub 2017 Dec 22.
    Department of Geriatric Medicine, Princess Royal University Hospital, Orpington, UK.
    A 97-year-old woman presented with 4-day history of vesicular rash, initially at the feet but then spread up to the thighs bilaterally, abdomen and trunk. The initial differentials included bullous pemphigus and cellulitis by the emergency department. She was then managed as bullous pemphigus by the acute medical team and started on high-dose steroids, with no other differentials considered. Read More

    The importance of direct immunofluorescence in pemphigus herpetiformis diagnosis.
    An Bras Dermatol 2017 ;92(5 Suppl 1):145-147
    Dermatology Outpatient Clinic at Hospital do Açúcar de Alagoas do Centro Universitário Tiradentes, Maceió, Alagoas (AL), Brazil.
    Pemphigus herpetiformis is an autoimmune bullous disease, that combines clinical features of dermatitis herpetiformis and linear IgA bullous dermatosis and immunological characteristics of pemphigus, which makes this disease peculiar and this diagnosis rarely suspected in the first evaluation of the patient. The reported case is of a patient with clinically bullous disease similar to dermatitis herpetiformis, whose multiple biopsies were inconclusive, and only after direct immunofluorescence with a pemphigus pattern (intraepidermal intercellular pattern) the confirmation of the diagnosis was possible. Read More

    Pemphigus foliaceus with pustular presentation in a patient with psoriasis.
    An Bras Dermatol 2017 ;92(5 Suppl 1):115-117
    Dermatology Department at Hospital Universitário Pedro Ernesto, of the Universidade do Estado do Rio de Janeiro (Hupe-Uerj) - Rio de Janeiro (RJ), Brazil.
    Pemphigus foliaceus is a chronic autoimmune disease of the skin, clinically characterized by scaly and crusty cutaneous erosions involving the seborrheic areas. The patient can eventually become erythrodermic. There are reports of atypical cases of pemphigus foliaceus with pustules and neutrophils, and clinical differentiation from generalized pustular psoriasis of von Zumbusch is difficult. Read More

    Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patient.
    An Bras Dermatol 2017 ;92(5 Suppl 1):34-36
    Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China.
    Bullous pemphigoid is a blistering autoimmune disease characterized by two hemidesmosomal proteins (anti-BP180 and 230). Pemphigus, by contrast, is characterized by two autoantibodies (anti-desmoglein 1 and 3). Coexistence of autoantibodies of bullous pemphigoid and pemphigus in a patient is rare. Read More

    Inpatient Mortality Resulting from Dermatological Disorders at a Tertiary Care Center in Eastern India: A Record-based Observational Study.
    Indian J Dermatol 2017 Nov-Dec;62(6):626-629
    Department of Dermatology, Venereology, and Leprosy, Medical College, Kolkata, West Bengal, India.
    Background: Contrary to popular perception, several dermatological conditions may be associated with lethal outcome in the absence of timely intervention or due to complications.

    Aims: The aim was to estimate the number of deaths and analyze their causes due to skin disorders at a tertiary level inpatient dermatology ward.

    Materials And Methods: We conducted a retrospective, record-based observational study involving 538 patients spanning over 4 years (2013-2016) at our dermatology indoor setup. Read More

    MPO-ANCA associated vasculitis with mononeuritis multiplex following influenza vaccination.
    Allergy Asthma Clin Immunol 2017 13;13:49. Epub 2017 Dec 13.
    Department of Internal Medicine, IJsselland Hospital, Capelle aan den IJssel, The Netherlands.
    Background: Although influenza vaccines are generally safe and effective, a variety of autoimmune phenomena have been reported after vaccination over the past years, such as Guillain-Barre syndrome, rheumatoid arthritis, pemphigus vulgaris, psoriasis, giant cell arteritis and anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV).

    Case Report: We describe the case of a 67-year old man who presented with a myeloperoxidase-ANCA associated vasculitis with renal involvement and mononeuritis multiplex after seasonal influenza vaccination. He was initially treated with intravenous cyclophosphamide and high-dose prednisolone followed by maintenance treatment consisting of azathioprine and prednisolone. Read More

    The Value of the BIOCHIP Mosaic-based Indirect Immunofluorescence Technique in the Diagnosis of Pemphigus and Bullous Pemphigoid in Turkish Patients.
    Acta Dermatovenerol Croat 2017 Oct;25(3):202-209
    Prof. Soner Uzun, MD, Department of Dermatology and Venerology Akdeniz University, School of Medicine, 07058 Antalya, Turkey;
    Autoimmune bullous diseases (ABD) are a rarely seen group of diseases, of which pemphigus and bullous pemphigoid (BP) are the major groups. Diagnosis is generally based on the combination of clinical features, histopathologic and immunofluorescence (IF) findings, and/or enzyme-linked immunosorbent assay (ELISA). Aims of the work were to determine the value of the innovative BIOCHIP mosaic-based indirect IF technique in the diagnosis of pemphigus and BP in Turkish patients. Read More

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