10,098 results match your criteria Pemphigus Vulgaris


Low-dose naltrexone therapy in benign chronic pemphigus (Hailey-Hailey disease): a case series.

J Am Acad Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Dermatology Department, Hospital Clínic de Barcelona, Universidad de Barcelona, Barcelona, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01909622193061
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http://dx.doi.org/10.1016/j.jaad.2019.04.024DOI Listing
April 2019
2 Reads

Editorial: Skin Blistering Diseases.

Front Med (Lausanne) 2019 2;6:60. Epub 2019 Apr 2.

Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.3389/fmed.2019.00060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454141PMC
April 2019
1 Read

Proinflammatory Cytokine Gene Polymorphisms in Bullous Pemphigoid.

Front Immunol 2019 29;10:636. Epub 2019 Mar 29.

Skin Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Bullous pemphigoid (BP) is a rare autoimmune skin blistering disease, characterized by the presence of autoantibodies against hemidesmosomal autoantigens. Cytokine expression is altered in BP patients, and several of these differently expressed cytokines, including IL-1α, IL-1β, IL-8, and TNF-α, contribute to disease pathogenesis. Since genetic polymorphisms in the genes of these cytokines might be implicated in susceptibility to BP disease, we aimed at testing this implication in susceptibility to BP in an Iranian cohort. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455081PMC

Editorial: Autoantibodies.

Front Immunol 2019 2;10:484. Epub 2019 Apr 2.

Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.00484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454132PMC

Illness perception of patients with pemphigus vulgaris.

Int J Womens Dermatol 2019 Jun 19;5(2):96-99. Epub 2018 Nov 19.

Care and Public Health Research Institute, Maastricht University Medical Center, Maastricht, the Netherlands.

Objective: Little is known about illness perception in patients with pemphigus vulgaris (PV). We designed a cross-sectional study to clarify the beliefs about PV.

Methods: A total of 100 patients with PV (45 men, 55 women) completed the Illness Perception Questionnaire-Revised to assess beliefs about seven aspects of illness perception, including chronicity, recurrence, consequences, self and medicine role in controlling illness, coherence, and emotional representation. Read More

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http://dx.doi.org/10.1016/j.ijwd.2018.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451738PMC
June 2019
1 Read

Non-endemic erythrodermic pemphigus foliaceus: a case with delayed diagnosis and response to rituximab.

J Dtsch Dermatol Ges 2019 Apr 17. Epub 2019 Apr 17.

Bullous Diseases Outpatient Clinic, 2nd Department of Dermatology & Venereology, Aristotle University School of Medicine, Papageorgiou General Hospital, Thessaloniki, Greece.

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http://dx.doi.org/10.1111/ddg.13836DOI Listing

A Clinicopathological and Immunofluorescence Study of Intraepidermal Immunobullous Diseases.

Indian J Dermatol 2019 Mar-Apr;64(2):101-105

Departments of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.

Context: Autoimmune blistering diseases (AIBDs) are characterized by autoantibodies directed against antigens of skin. Direct immunofluorescence (DIF) study helps in confirming the diagnosis where histopathology alone is noncontributory.

Aims: This study aimed to evaluate the clinicopathological and DIF features of intraepidermal AIBD and to assess their relative diagnostic significance. Read More

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http://dx.doi.org/10.4103/ijd.IJD_515_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440185PMC
April 2019
2 Reads

Risk factors for death and survival in paraneoplastic pemphigus associated with hematologic malignancies in adults.

J Am Acad Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Assistance Publique-Hôpitaux de Paris, Département de Dermatologie, Hôpital Saint-Louis, Paris, France; Université Paris-Diderot, Sorbonne Paris Cité, Paris, France. Electronic address:

Background: Paraneoplastic pemphigus (PNP) occurs more often in patients with hematologic malignancies (HMs) than in patients with solid cancer. Lung bronchiolitis obliterans (BO) is a severe complication of PNP.

Objective: To determine the precise clinical and biologic features of HM-associated PNP and identify factors associated with mortality and survival. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.03.043DOI Listing
April 2019
2 Reads

Pemphigus vegetans initiating on the finger and nail.

Eur J Dermatol 2019 Apr 12. Epub 2019 Apr 12.

Department of Dermatology, Eberhard-Karls-University, Liebermeisterstrasse 25, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1684/ejd.2018.3407DOI Listing

Pemphigus subtype: A confounder in determining the association of oral involvement with post-rituximab relapses.

Dermatol Ther 2019 Apr 12:e12918. Epub 2019 Apr 12.

Department of Dermatology, University of Illinois at Chicago.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.12918
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http://dx.doi.org/10.1111/dth.12918DOI Listing

Pharmacological advances in pemphigus.

Curr Opin Pharmacol 2019 Apr 8;46:44-49. Epub 2019 Apr 8.

St George Hospital, UNSW Department of Dermatology, Kogarah, Sydney, NSW 2217, Australia. Electronic address:

This is an updated review of the literature on the emerging therapeutic options for the treatment of pemphigus to provide better care for patients. There is an increasing range of molecules targeted for pemphigus therapy against CD20, Bruton tyrosine kinase, chimeric antigen receptor, T-cell immune components, B-cell activating factor, proliferation-inducing ligand (APRIL), CD25, p38 mitogen-activated protein kinase (p38MAPK) and cytokine modulation therapies (anti-IL-4, anti-IL-6). The main aim of the current new therapies is to provide specific pathology-focused therapeutic options which have long-term sustainable therapeutic effects on disease progress, cause less side effects without systemic immunosuppression, and have less risk of getting antibodies against the medication during treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14714892183009
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http://dx.doi.org/10.1016/j.coph.2019.01.001DOI Listing
April 2019
4 Reads

Pemphigus vulgaris, steroid management with ongoing psychosis.

Int J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Dermatology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ijd.14467
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http://dx.doi.org/10.1111/ijd.14467DOI Listing

Clinical Outcomes of Pemphigus Patients Treated by the Same Physicians in a Public Safety Net Healthcare System Versus a Private Healthcare System.

Br J Dermatol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology, The Keck School of Medicine, University of Southern California, USC/Norris Cancer Center, Topping Tower #3405, 1441 Eastlake Avenue, Los Angeles, CA, USA.

Healthcare may be influenced by the healthcare system to which the patient is aligned as well as the characteristics of the patients within a given healthcare system. The University of Southern California (USC) has two healthcare systems on the same campus - the private system (PS) University Hospital for patients with healthcare insurance and the safety net system (SNS), Los Angeles County Hospital for indigent patients. The same USC physicians provide care in both systems. Read More

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http://dx.doi.org/10.1111/bjd.17983DOI Listing
April 2019
2 Reads

Use of low-dose naltrexone in the treatment of severe hailey-hailey disease: one case report.

Dermatol Ther 2019 Apr 8:e12892. Epub 2019 Apr 8.

Department of Dermatology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.

Introduction: Hailey-Hailey disease (HHD) or chronic benign familial pemphigus is an autosomal dominant genodermatosis with complete penetrance characterized by painful vesicles, erosions and macerated intertriginous skin.

Case Report: We present a 66-year-old woman with a personal 35-year history of pruritic recurrent vesicles and erosions in both axillae and inguinal folds. HHD was confirmed by cutaneous biopsy. Read More

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http://dx.doi.org/10.1111/dth.12892DOI Listing
April 2019
1 Read

[Autoimmune blistering dermatoses in children].

Hautarzt 2019 Apr;70(4):277-282

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Hauptstr. 7, 79104, Freiburg, Deutschland.

Autoimmune blistering skin disorders represent a rare group of autoantibody-induced dermatoses against desmosomal and hemidesmosomal molecules. The common age of onset for pemphigus and pemphigoid, as well as dermatitis herpetiformis, encompasses the adult age, but all these disorders can be observed neonatally and/or during childhood. If the disease occurs postpartum or neonatally, physicians should consider transplacental transmission of pathogenic maternal immunoglobulin G (IgG)-autoantibodies, and both mother and child should be included in the diagnostic work up. Read More

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http://dx.doi.org/10.1007/s00105-019-4379-7DOI Listing
April 2019
4 Reads

Measuring the quality of life in pemphigus.

Authors:
C Sitaru

Br J Dermatol 2019 Apr;180(4):705

Department of Dermatology, Medical Faculty, Medical Center - University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1111/bjd.17616DOI Listing
April 2019
2 Reads

Unfolding the genetic basis of pemphigus.

Authors:
S Geller

Br J Dermatol 2019 Apr;180(4):713-714

Department of Dermatology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel.

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http://dx.doi.org/10.1111/bjd.17621DOI Listing

[Update of the French recommendations for the management of pemphigus].

Ann Dermatol Venereol 2019 Mar 28. Epub 2019 Mar 28.

Service de dermatologie, Inserm U1234, université de Normandie, CHU de Rouen, 1 rue de Germont, 76000 Rouen, France; Service de dermatologie, université Paris 13, hôpital Avicenne, AP-HP, 93000 Bobigny, France; Service de dermatologie, hôpital Henri-Mondor, AP-HP, 94000 Créteil, France; Service de dermatologie, hôpital Robert-Debré, CHU de Reims, 51092 Reims, France; Service de dermatologie, hôpital Dupuytren, 87042 Limoges, France; Service de dermatologie, Inserm U1058, université de Montpellier, hôpital St-Eloi, 34295 Montpellier, France; Service de dermatologie, CHU Hôtel-Dieu, 44093 Nantes, France; Service de dermatologie, hôpital Trousseau, CHRU de Tours, 37044 Tours, France; Service de dermatologie, hôpital Bichat-Claude-Bernard, AP-HP, 75018 Paris, France; Service de dermatologie, hôpital Claude-Huriez, CHRU de Lille, 59037 Lille, France; EA3279 : CEReSS-centre d'étude et de recherche sur les services de santé et la qualité de vie, service de dermatologie, université Aix-Marseille, hôpital de La Timone, Assistance publique-Hôpitaux de Marseille, 13385 Marseille, France; Service de dermatologie, université Aix-Marseille, hôpital Nord, Assistance publique-Hôpitaux de Marseille, 13385 Marseille, France; Service de dermatologie, hôpital Edouard-Herriot, hospices civils de Lyon, 69437 Lyon, France; Service de dermatologie, CHU Estaing, 63000 Clermont-Ferrand, France; Service de dermatologie, hôpital Larrey, CHU de Toulouse, 31059 Toulouse, France; Service de dermatologie, hôpital Saint-Louis, AP-HP, 75010 Paris, France; Service de dermatologie, hôpital Saint-André, CHU de Bordeaux, 33000 Bordeaux, France; Service de dermatologie, hôpital Ambroise-Paré, AP-HP, 92100 Boulogne-Billancourt, France; Unité de dermatologie-immunologie clinique, CHU de Guadeloupe, 97159 Pointe-à-Pitre cedex, Guadeloupe; Service de médecine interne et pneumologie, hôpital de la Cavale-Blanche, CHRU de Brest, 29609 Brest, France; Inserm U1234, laboratoire d'immunologie, université de Normandie, CHU de Rouen, 76000 Rouen, France.

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http://dx.doi.org/10.1016/j.annder.2019.01.018DOI Listing
March 2019
1 Read

Non-Myasthenia Gravis Immune Syndromes and the Thymus: Is There a Role for Thymectomy?

Thorac Surg Clin 2019 May 7;29(2):215-225. Epub 2019 Mar 7.

Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University Hospitals and Clinics, 300 Pasteur Drive, Stanford, CA 94305, USA. Electronic address:

Thymectomy has long been considered, performed, and discussed for many different nonmyasthenic immune syndromes. Thymectomy is now an established treatment for MG, and has been performed for other immune syndromes with varying degrees of improvement. Although numerous reports document immune syndromes' association with thymoma, few address the role of thymectomy in symptom resolution. Read More

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http://dx.doi.org/10.1016/j.thorsurg.2018.12.008DOI Listing
May 2019
3 Reads

High-resolution melting analysis to screen the ST18 gene functional risk variant for pemphigus vulgaris: The occasion to open a debate on its usefulness in clinical setting.

Exp Mol Pathol 2019 Mar 26;108:57-63. Epub 2019 Mar 26.

UOC Laboratory Medicine, Genetics and Toxicology, IDI IRCCS, Fondazione Luigi Maria Monti, Via Monti di Creta 104, Rome, Italy; Polo Scienze per Immagini, di Laboratorio e Infettivologiche, "Fondazione Policlinico Agostino Gemelli" - IRCCS, Rome, Italy. Electronic address:

The ST18 -497-65050 T > C polymorphisms (rs17315309) exhibit a very strong association in the pathogenesis of Pemphigus Vulgaris (PV) and could represent a new potential molecular target for the treatment of disease. The present study aimed to establish a low-cost, sensitive and reliable assay using high-resolution melting curve analysis (HRMA) on magnetic induction rotor-based platform, the Magnetic Induction Cycler (MIC) (Bio molecular Systems). HRMA assay was able to identify easily and unambiguously the c. Read More

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http://dx.doi.org/10.1016/j.yexmp.2019.03.009DOI Listing
March 2019
2.706 Impact Factor

[IGA Pemphigus].

Presse Med 2019 Mar 26. Epub 2019 Mar 26.

Hôpital militaire d'instruction Mohammed V, service de dermatologie, 10000 Hay Riad, Rabat, Maroc.

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http://dx.doi.org/10.1016/j.lpm.2019.02.014DOI Listing

The use of BIOCHIP technique in diagnosis of different types of pemphigus: Vulgaris and foliaceus.

J Immunol Methods 2019 May 22;468:35-39. Epub 2019 Mar 22.

Department of Dermatology and Immunodermatology, Medical University of Warsaw, Poland.

Background: Pemphigus is a rare, autoimmune blistering disease characterized by autoantibodies against desmoglein 3 (Dsg3) and 1 (Dsg1) with mucosal and/or skin involvement. Main types of pemphigus include mucosal pemphigus vulgaris (m-PV), mucocutaneus pemphigus vulgaris (mc-PV) and pemphigus foliaceus (PF) determined by clinical picture, positive direct and indirect immunofluorescence, and enzyme-linked immunosorbent assay (ELISA).

Methods: We evaluated the sensitivity and specificity of a novel multi-substrate immunofluorescence technique called BIOCHIP in the diagnosis of main types of pemphigus. Read More

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http://dx.doi.org/10.1016/j.jim.2019.03.009DOI Listing

Clinical, pathologic, and immunologic features of pemphigus herpetiformis: a literature review and proposed diagnostic criteria.

Int J Dermatol 2019 Mar 22. Epub 2019 Mar 22.

Department of Dermatology, Mayo Clinic, Jacksonville, FL, USA.

Pemphigus herpetiformis (PH), a rare type of pemphigus, is characterized by immunologic findings consistent with pemphigus but with a unique clinical and pathologic presentation. PH was first described as resembling dermatitis herpetiformis clinically, but because of its variable presentation, it can also resemble linear immunoglobulin A bullous dermatosis and bullous pemphigoid. We reviewed reported cases to analyze the most frequent clinical, pathologic, and immunologic characteristics and to propose corresponding diagnostic criteria. Read More

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http://dx.doi.org/10.1111/ijd.14395DOI Listing

Prevalence Estimates for Pemphigus in the United States: A Sex- and Age-Adjusted Population Analysis.

JAMA Dermatol 2019 Mar 20. Epub 2019 Mar 20.

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.

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http://dx.doi.org/10.1001/jamadermatol.2018.5954DOI Listing

The use of naltrexone in dermatology. Current evidence and future directions.

Curr Drug Targets 2019 Mar 18. Epub 2019 Mar 18.

Department of Dermatology, Medical University of Warsaw, Warsaw. Poland.

Naltrexone is a competitive opioid receptor antagonist approved as supportive treatment in alcohol dependence and opioid addiction. In a dose 50-100 mg daily, naltrexone is used off-label in dermatology for the treatment of trichotillomania and different types of pruritus. At a dose as low as 1-5 mg of drug per day, naltrexone demonstrates immunomodulatory action i. Read More

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http://dx.doi.org/10.2174/1389450120666190318121122DOI Listing
March 2019
13 Reads

[Therapy of pemphigus].

Hautarzt 2019 Apr;70(4):243-253

Klinik für Dermatologie, Allergologie und Venerologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Background: Pemphigus diseases are a heterogeneous group of potentially life-threatening autoimmune bullous disorders. Therefore, rapidly acting and effective therapeutic approaches are essential.

Objectives: In this review, current therapeutic options in line with available guidelines are presented and new therapeutic approaches are discussed. Read More

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http://dx.doi.org/10.1007/s00105-019-4385-9DOI Listing
April 2019
1 Read

Autoimmunity and immunological tolerance in autoimmune bullous diseases.

Int Immunol 2019 Mar 19. Epub 2019 Mar 19.

Department of Dermatology, Keio University School of Medicine, Shinanomachi, Shinjuku-ku Tokyo, Japan.

Autoimmune diseases are devastating conditions in which the immune system is directed against the host, leading to life-threatening destruction of organs. Although autoantigens are ill-defined in most autoimmune diseases, this is not the case in the skin. Autoimmune bullous diseases have been extensively studied with detailed characterization of autoantigens, the epitopes that are targeted, and the mechanisms of action that mediate autoimmune tissue destruction. Read More

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http://dx.doi.org/10.1093/intimm/dxz030DOI Listing
March 2019
1 Read

Region 1p13.2 including the RSBN1, PTPN22, AP4B1 and long non-coding RNA genes does not bear risk factors for endemic pemphigus foliaceus (fogo selvagem).

Int J Immunogenet 2019 Mar 18. Epub 2019 Mar 18.

Laboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná, Curitiba, Brazil.

Pemphigus foliaceus (PF) is an autoimmune skin disease characterized by autoantibodies directed mainly against desmoglein-1. The purpose of this study was to determine whether differential susceptibility to endemic PF in Brazil (fogo selvagem) is associated with polymorphisms at the cytogenetic location 1p13.2. Read More

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http://dx.doi.org/10.1111/iji.12423DOI Listing
March 2019
1 Read

Unexpected worsening of pemphigus vulgaris after rituximab: A report of three cases.

Int Immunopharmacol 2019 Mar 12;71:40-42. Epub 2019 Mar 12.

Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

During the recent decade, several studies have confirmed the high efficacy of targeting the CD20 molecules using rituximab (RTX). Recently, RTX has been suggested as the first-line treatment of pemphigus vulgaris (PV). In this study, the records of all the PV patients, who had received RTX in Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences between the 2009 and 2017, have been reviewed for any sign of disease worsening within three months after treatment. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.037DOI Listing
March 2019
4 Reads

Review of paraneoplastic syndromes in children.

Pediatr Radiol 2019 Apr 16;49(4):534-550. Epub 2019 Mar 16.

Department of Radiology, Boston Children's Hospital, 300 Longwood Ave., Boston, MA, 02215, USA.

Paraneoplastic syndromes are defined as clinical syndromes that are not related to direct tumor invasion or compression but are secondary to tumor secretion of functional peptides/hormones or related to immune cross-reactivity with normal host tissue. Paraneoplastic syndromes have a wide range of presentations and can present before the primary malignancy or tumor recurrence is diagnosed. They can mimic non-neoplastic processes, making detection, diagnosis and treatment difficult. Read More

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http://dx.doi.org/10.1007/s00247-019-04371-yDOI Listing
April 2019
5 Reads

Beware of anal fissures: pemphigus vulgaris of the anal canal.

Ann Gastroenterol 2019 Mar-Apr;32(2):205-207. Epub 2018 Dec 20.

Depatment of Dermatology, University General Hospital of Heraklion, Crete (Chara Karatzi, Maria Stefanidou, Eva Islamidou, George Evangelou, Sabine Krueger-Krasagakis, Konstantin Krasagakis), Greece.

A case of anal pemphigus vulgaris in a 49-year-old female suffering from pemphigus vulgaris of the oral cavity is reported. The oral manifestations were in remission until she presented with episodes of anal pain and bleeding on defecation, initially mimicking anal fissures. Inspection revealed prominent painful erosions in the anal canal with external hemorrhoids and strands of sloughing skin and maceration in the anal verge. Read More

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http://dx.doi.org/10.20524/aog.2018.0340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394260PMC
December 2018
5 Reads

Pemphigus foliaceous.

Can Vet J 2019 Mar;60(3):311-313

Dr. Goodale, Diplomate of the American College of Veterinary Dermatology, Guelph Veterinary Specialty Hospital, 1460 Gordon Street South, Guelph, Ontario N1L 1C8.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380263PMC

[Pemphigus].

Rev Prat 2018 Jun;68(6):636

Clinique médicale, hôpital Bégin, Saint-Mandé, France.

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Long-term evaluation of pemphigus vulgaris: A retrospective consideration of 98 patients treated in an oral medicine unit in north-west Italy.

J Oral Pathol Med 2019 Mar 12. Epub 2019 Mar 12.

Department of Oral Medicine, School of Dental Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.

Background: Despite the frequency of oral involvement, there are unexpectedly few studies of either on the oral manifestations of pemphigus or their long-term management, and diagnostic delay in Dentistry is frequent.

Methods: We have examined outcome of patients presenting with predominantly oral pemphigus vulgaris (PV). Ninety-eight subjects were followed up for 85. Read More

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http://dx.doi.org/10.1111/jop.12847DOI Listing
March 2019
3 Reads
1.870 Impact Factor

Treatment Update of Autoimmune Blistering Diseases.

Dermatol Clin 2019 Apr 14;37(2):215-228. Epub 2019 Feb 14.

Department of Medicine, University of Central Florida, Health Sciences Campus at Lake Nona, 2627 Northampton Avenue, Orlando, FL 32827-7408, USA. Electronic address:

The treatment of refractory autoimmune blistering diseases (AIBDs) has always been a challenge. Because randomized controlled trials are lacking, treatment has been based on analysis of anecdotal data. The last 2 decades has seen the use of rituximab become a conventional treatment in the therapeutic armamentarium of AIBDs, leading to its Food and Drug Administration indication for pemphigus vulgaris in 2018. Read More

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http://dx.doi.org/10.1016/j.det.2018.12.003DOI Listing

Translational Use of a Standardized Full Human Skin Organ Culture Model in Autoimmune Blistering Diseases.

Curr Protoc Pharmacol 2019 Mar 8:e56. Epub 2019 Mar 8.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

The full human skin organ culture (HSOC) model is a standardized test system for evaluating pharmacological substances on human skin in vitro. The acantholysis associated with pemphigus vulgaris (PV), a severe and potentially life-threatening autoimmune skin blistering disease, can be induced in HSOC by injecting a bi-specific anti-desmoglein (dsg) 1 and 3 single-chain antibody variable fragment (scFv). Compared to cell culture experiments (e. Read More

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http://dx.doi.org/10.1002/cpph.56DOI Listing
March 2019
1 Read

Serum and blister fluid levels of cytokines and chemokines in pemphigus and bullous pemphigoid.

Autoimmun Rev 2019 May 4;18(5):526-534. Epub 2019 Mar 4.

Department of Dermatology, University of Illinois at Chicago, USA. Electronic address:

Bullous pemphigoid and pemphigus constitute two major autoimmune blistering diseases (AIBD) with complicated disease pathomechanisms involving a multitude of cytokines and immunological pathways. The purpose of our literature review of the cytokines and chemokines involved in these AIBDs was to allow for a meta-analysis of studies detailing differential cytokine and chemokine changes in these conditions. Elucidation of inflammatory pathways could lead to more targeted therapies, several of which specific monoclonal antibodies already exist and are used safely for other autoimmune diseases. Read More

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http://dx.doi.org/10.1016/j.autrev.2019.03.009DOI Listing

[Ultrastructure of epidermocytes in true pemphigus acantholysis].

Arkh Patol 2019;81(1):3-8

Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, Russia.

Objective: To investigate the ultrastructure of epidermocytes in skin biopsy specimens, by taking into account an update on the pathomorphogenesis of true pemphigus acantholysis.

Material And Methods: Affected skin biopsy specimens from 4 patients with Pemphigus vulgaris (a mixed mucosal-epidermal variant) and from 1 patient with P. foliaceus at the onset of the disease in the absence of therapy were examined by light microscopy of semifine sections and by transmission electron microscopy. Read More

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http://dx.doi.org/10.17116/patol2019810113DOI Listing
January 2019
1 Read

Dapsone advantages over trimethoprim-sulfamethoxazole for Pneumocystis pneumonia prophylaxis in immunobullous patients.

J Am Acad Dermatol 2019 Feb 27. Epub 2019 Feb 27.

Division of Dermatology, University of Kansas Medical Center, Kansas City. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.01.091DOI Listing
February 2019
3 Reads

Tubular Hair Casts in Trichoscopy of Hair and Scalp Disorders.

Int J Trichology 2019 Jan-Feb;11(1):14-19

Department of Dermatology, College of Medical Sciences, Bharatpur, Nepal.

Introduction: Hair casts have been reported in a variety of hair and scalp disorders. Trichoscopy allows a quick and noninvasive method for the evaluation of hair and scalp disorders in high magnification. However, the study of hair casts seen in trichoscopy is lacking. Read More

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http://dx.doi.org/10.4103/ijt.ijt_77_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385511PMC
March 2019
12 Reads

Implants in patients with oral manifestations of autoimmune or muco-cutaneous diseases - A systematic review.

Med Oral Patol Oral Cir Bucal 2019 Mar 1;24(2):e217-e230. Epub 2019 Mar 1.

Charité - Universitaetsmedizin Berlin, Charité Centre 3 for Dental, Oral, and Maxillary Medicine, Department for Oral Medicine Dental Radiology, and Oral Surgery, Assmannshauser Str. 4-6, 14197 Berlin, Germany,

Background: To give an overview on implant survival rates in patients with oral manifestations of systemic autoimmune (oral Lichen planus (oLp), Pemphigus (Pe)), muco-cutaneous (Epidermolysis bullosa (EB)), autoimmune multisystemic rheumatic diseases (Sjögren's syndrome (SjS), systemic Lupus erythematosus (sLE), or systemic Sclerosis (sSc)).

Material And Methods: Systematic literature review (PubMed/Medline, Embase) using MESH and search term combinations, published between 1980 and August 2018 in English language reporting on dental implant-prosthetic rehabilitation of patients with oLp, Pe, EB, SjS, sLE, sSc, study design, age, gender, follow-up period (≥ 12 months), implant survival rate. Implant-related weighed mean values of implant survival rate (wmSR) were calculated. Read More

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http://www.medicinaoral.com/medoralfree01/aop/22786.pdf
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http://dx.doi.org/10.4317/medoral.22786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441598PMC
March 2019
8 Reads

Oral hygiene instructions and professional control as part of the treatment of desquamative gingivitis. Systematic review.

Med Oral Patol Oral Cir Bucal 2019 Mar 1;24(2):e136-e144. Epub 2019 Mar 1.

Department of Oral Medicine, Faculty of Medicine and Sciences of the Health, Julian Clavería, 33006 Oviedo, Spain,

Background: The aim of this present article was to evaluate the scientific evidence on the efficacy of daily hygiene and professional prophylaxis for treatment of desquamative gingivitis.

Material And Methods: The present systematic review was conducted following the PRISMA protocol. Searches were carried out in Pubmed, Embase, Web of Science and Cochrane Library up to July 2018, randomized clinical trials and cohort studies on desquamative gingivitis (DG), and oral diseases joined to DG. Read More

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http://dx.doi.org/10.4317/medoral.22782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441599PMC
March 2019
2 Reads

Oxidative Stress and Oral Mucosal Diseases: An Overview.

In Vivo 2019 Mar-Apr;33(2):289-296

Section of Dentistry, Interdisciplinary Department of Medicine, School of Medicine, Aldo Moro University of Bari, Bari, Italy

Background: Reactive oxygen species (ROS) and free radicals are physiologically produced during cellular metabolism. When their balance is disrupted in favor of ROS, a condition called oxidative stress occurs. Oxidative stress represents a widespread phenomenon involved in several pathological conditions. Read More

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http://dx.doi.org/10.21873/invivo.11474DOI Listing
November 2018
1 Read

Clinicopathological findings and clinical outcomes in 49 cases of feline pemphigus foliaceus examined in Northern California, USA (1987-2017).

Vet Dermatol 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA.

Background: Few studies have described the pathophysiology, clinical course, treatment outcomes and quality of life (QoL) of cats with pemphigus foliaceus (PF).

Objective: Describe clinicopathological features, treatment outcomes and impacts on QoL in feline PF.

Animals: Forty-nine client-owned cats with PF that presented to a veterinary teaching hospital between 1987 and 2017. Read More

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http://dx.doi.org/10.1111/vde.12731DOI Listing
February 2019

Emerging role of immune cell network in autoimmune skin disorders: An update on pemphigus, vitiligo and psoriasis.

Cytokine Growth Factor Rev 2019 02 8;45:35-44. Epub 2019 Feb 8.

Department of Biochemistry, All India Institute of Medical Sciences, AIIMS, New Delhi, India. Electronic address:

Autoimmune skin diseases are a group of disorders that arise due to a deregulated immune system resulting in skin tissue destruction. In the majority of these conditions, either autoreactive immune cells or the autoantibodies are generated against self-antigens of the skin. Although the etiology of these diseases remains elusive, biochemical, genetic, and environmental factors such as infectious agents, toxins damage the skin tissue leading to self-antigen generation, autoantibody attack and finally results in autoimmunity of skin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13596101193000
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http://dx.doi.org/10.1016/j.cytogfr.2019.01.001DOI Listing
February 2019
3 Reads
5.357 Impact Factor

Childhood pemphigus foliaceus presenting as a polycyclic eruption: Case report and review of the literature.

Pediatr Dermatol 2019 Mar 14;36(2):236-241. Epub 2019 Feb 14.

Department of Dermatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

Pemphigus foliaceus (PF) is an autoimmune bullous disorder that has occasionally been reported to present as a polycyclic or arcuate eruption in children. We present a case of childhood PF presenting as an annular and polycyclic eruption, which initially led to a diagnostic conundrum and a delay in diagnosis but which ultimately responded well to therapy with systemic steroids and rituximab infusions. We briefly review the literature on polycyclic presentations of PF in childhood as well as the use of rituximab for pediatric pemphigus. Read More

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http://dx.doi.org/10.1111/pde.13750DOI Listing
March 2019
2 Reads

Infective endocarditis in two patients with pemphigus vulgaris under multiagent immunosuppressive drug therapy: A rare entity to remember in the differential diagnosis of fever of unknown origin.

Dermatol Ther 2019 Feb 13:e12860. Epub 2019 Feb 13.

Department of Dermatology and Venereology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Pemphigus vulgaris (PV) is an autoimmune blistering skin disease that may require multiagent immunosuppressive drug therapies in severe cases. In addition to the well-established corticosteroid sparing agents azathioprine, mycophenolate mofetil, and methotrexate, rituximab is being increasingly used alone or in combination in the management of PV. Due to the chronic course of the disease, the cumulative effects of these therapy agents over long follow-up periods may result in various adverse reactions, including bacterial and viral infections. Read More

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http://dx.doi.org/10.1111/dth.12860DOI Listing
February 2019
2 Reads

Improving Treatment Outcome of Pemphigus Vulgaris on Vietnamese Patients by Using Desmoglein Elisa Test.

Open Access Maced J Med Sci 2019 Jan 22;7(2):195-197. Epub 2019 Jan 22.

Psoriasis Eczema Clinic, Melbourne, Australia.

Background: Pemphigus Vulgaris (PV) is a chronic disease, is characterized by the presence of flacid bullous in skin and mucosa. There are 2 main autoantibodies against desmoglein3 (Dsg3) and desmoglein1 (Dsg1).

Aim: The aims of this study were to evaluate the before and after treatment outcome with corticosteroid, using Desmoglein ELISA test. Read More

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http://dx.doi.org/10.3889/oamjms.2019.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364727PMC
January 2019

Pemphigus and mucous membrane pemphigoid: An update from diagnosis to therapy.

Autoimmun Rev 2019 Apr 7;18(4):349-358. Epub 2019 Feb 7.

Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine "Guido Baccelli", University of Bari Medical School, Bari, Italy. Electronic address:

Pemphigus diseases (PDs) and mucous membrane pemphigoid (MMP) are a group of immune-mediated mucocutaneous disorders clinically characterized by the formation of blisters, erosions and ulcers. The skin and mucous membranes are predominantly affected, with the oropharyngeal mucosa as the initially involved site. Ocular involvement is also a frequent feature of these diseases. Read More

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http://dx.doi.org/10.1016/j.autrev.2019.02.005DOI Listing
April 2019
19 Reads

Cutaneous paraneoplastic syndromes.

Semin Diagn Pathol 2019 Jan 31. Epub 2019 Jan 31.

PRW Laboratories, Charlottesville, VA, United State.

A variety of cutaneous abnormalities can be seen in patients with malignant diseases, some of which are infectious, with others representing direct involvement of the skin by the underlying disorder. Yet another group of lesions can be regarded as associated markers of the malignant process, and, as such, are termed "paraneoplastic." This review considers the latter collection of conditions, grouping them by the generic type of malignancy that is usually linked to the paraneoplasia. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.01.001DOI Listing
January 2019
15 Reads