9,824 results match your criteria Pemphigus Vulgaris


A case of antiepiligrin cicatricial pemphigoid with extensive cutaneous erosions mimicking pemphigus vulgaris.

BMJ Case Rep 2018 Jun 21;2018. Epub 2018 Jun 21.

Department of Dermatology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Cicatricial pemphigoid (CP) is a chronic, autoimmune, subepidermal blistering disease with predominant mucosal involvement. In this article, we report a young patient with mucosal and extensive cutaneous involvement in the form of large erosions mimicking those of pemphigus vulgaris thus leading to diagnostic dilemma. We were unable to find any other previous reports with such extensive cutaneous erosions mimicking those of pemphigus vulgaris. Read More

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June 2018
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Bullous Pemphigoid in an Infant: A Case Report.

Prehosp Disaster Med 2018 Jun 22:1-3. Epub 2018 Jun 22.

2Bégin Military Teaching Hospital,Saint-Mandé,France.

A seven-month-old girl was referred to the emergency department (ED) after a general practitioner suspected Steven-Johnson syndrome. Actually, the diagnosis of bullous pemphigoid (BP) was made based on biopsies; BP is a rare, autoimmune skin disease involving the presence of blisters known as bullae. The child was efficiently treated with topical steroids. Read More

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Paraneoplastic Pemphigus as a First Manifestation of an Intra-Abdominal Follicular Dendritic Cell Sarcoma: Rare Case and Review of the Literature.

Case Rep Oncol 2018 May-Aug;11(2):353-359. Epub 2018 May 31.

Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Background: Follicular dendritic cell sarcoma (FDCS) is an extremely rare malignant tumor caused by proliferation of antigen-presenting follicular dendritic cells. The tumor most commonly arises in lymph nodes, with fewer than 30% of cases originating in extranodal sites.

Case Presentation: We report the case of a 39-year-old previously healthy male patient who presented with paraneoplastic pemphigus in the setting of a large intraperitoneal mass with no associated lymphadenopathy. Read More

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Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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June 2018
2 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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June 2018
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Keratin Retraction and Desmoglein3 Internalization Independently Contribute to Autoantibody-Induced Cell Dissociation in Pemphigus Vulgaris.

Front Immunol 2018 25;9:858. Epub 2018 Apr 25.

Chair of Vegetative Anatomy, Faculty of Medicine, Institute of Anatomy, Ludwig Maximilian University of Munich, Munich, Germany.

(PV) is a potentially lethal autoimmune disease characterized by blister formation of the skin and mucous membranes and is caused by autoantibodies against desmoglein (Dsg) 1 and Dsg3. Dsg1 and Dsg3 are linked to keratin filaments in desmosomes, adhering junctions abundant in tissues exposed to high levels of mechanical stress. The binding of the autoantibodies leads to internalization of Dsg3 and a collapse of the keratin cytoskeleton-yet, the relevance and interdependence of these changes for loss of cell-cell adhesion and blistering is poorly understood. Read More

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Non-Desmoglein Antibodies in Patients With Pemphigus Vulgaris.

Front Immunol 2018 4;9:1190. Epub 2018 Jun 4.

Department of Dermatology, University of California Irvine, Irvine, CA, United States.

Pemphigus vulgaris (PV) is a potentially life-threatening mucocutaneous autoimmune blistering disease. Patients develop non-healing erosions and blisters due to cell-cell detachment of keratinocytes (acantholysis), with subsequent suprabasal intraepidermal splitting. Identified almost 30 years ago, desmoglein-3 (Dsg3), a Ca-dependent cell adhesion molecule belonging to the cadherin family, has been considered the "primary" autoantigen in PV. Read More

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June 2018
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Rituximab-Treated Pemphigus Foliaceus in a Schizophrenic Patient: A Challenging Exercise in Diagnosis, Management, and Follow-Up.

Skinmed 2018 1;16(2):129-131. Epub 2018 Apr 1.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA;

Dermatology was consulted in the care of a 58-year-old man with a history of paranoid schizophrenia, neuroleptic malignant syndrome, a positive purified protein derivative test, and a lack of bathing for approximately 4 years who had been admitted to the hospital because of thick, crusted lesions over an increasing portion of his body. Admitted involuntarily, he was disinterested in the history, physical examination, and diagnostic testing. Comorbid schizophrenia presented a unique challenge because he was unable to participate in his care effectively. Read More

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Autoimmune Thyroid Diseases and Thyroid Cancer in Pemphigus: A Big Data Analysis.

Front Med (Lausanne) 2018 30;5:159. Epub 2018 May 30.

Department of Quality Measurements and Research, Clalit Health Services, Tel Aviv, Israel.

There is a little consensus regarding the association of pemphigus with autoimmune thyroid diseases. While this association had been confirmed by some observational studies, others had refuted it. We aimed to study the association between pemphigus and Hashimoto's thyroiditis, Grave's disease, and thyroid cancer using a large-scale real-life computerized database. Read More

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May 2018
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Validity of the EQ-5D in pemphigus vulgaris and foliaceus patients.

Br J Dermatol 2018 Jun 13. Epub 2018 Jun 13.

Department of Health Economics, Corvinus University of Budapest, Fővám tér 8. H-1093, Budapest, Hungary.

Background: No studies have employed the EuroQoL (EQ-5D) questionnaire to assess health-related quality of life (HRQoL) in pemphigus patients, to date.

Objectives: To evaluate HRQoL of pemphigus patients by the EQ-5D and to analyse the convergent and known-groups validity of the EQ-5D in this patient population.

Methods: Between 2014 and 2017, a multicentre cross-sectional study was carried out. Read More

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June 2018
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Rituximab/IVIG in pemphigus - a 10 year study with a long follow-up.

J Dermatolog Treat 2018 Jun 11:1-22. Epub 2018 Jun 11.

a Department of Dermatology , King Faisal Specialist Hospital and Research Centre , Riyadh , Saudi Arabia.

Background: Pemphigus is a chronic potentially life threatening autoimmune blistering disease affecting the skin and/or mucous membranes. Rituximab is being increasingly used and found efficacious in the treatment of pemphigus.

Objective: To present the Middle-Eastern experience with the use of rituximab in pemphigus. Read More

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June 2018
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Buccal paraneoplastic pemphigus multi-resistant: Case report and review of diagnostic and therapeutic strategies.

J Stomatol Oral Maxillofac Surg 2018 Jun 8. Epub 2018 Jun 8.

Department of oral and maxillofacial surgery, cliniques universitaires Saint-Luc, université catholique de Louvain, avenue Hippocrate 10, 1200 Woluwe-Saint-Lambert, Belgium.

Paraneoplastic pemphigus is a rare autoimmune blistering disease generally associated with malignancy. The clinical presentation consists typically of painful and diffuse erosive stomatitis that may be accompanied by polymorphic skin lesions and systemic involvement. Diagnosis is based on clinical manifestations and confirmed by histology and immunological testing. Read More

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June 2018
3 Reads

Incidence of pemphigus vulgaris and pemphigus foliaceus in North-East Poland (Podlaskie Province) - a 15-year (2001-2015) bicentric retrospective study.

Int J Dermatol 2018 Jun 5. Epub 2018 Jun 5.

Department of Dermatology and Venereology, Medical University of Bialystok, Bialystok, Poland.

Background: The average incidence of pemphigus reported from European countries ranged between 0.5 and eight cases per one million inhabitants. Studies on epidemiology of pemphigus group in entire Province of Poland over a period of more than a decade are lacking. Read More

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June 2018
2 Reads

New onset pemphigus foliaceus during pregnancy: A rare case.

Int J Womens Dermatol 2018 Jun 8;4(2):109-112. Epub 2017 Dec 8.

Second Department of Dermatology, Aristotle University School of Medicine, Papageorgiou General Hospital, Thessaloniki, Greece.

Pemphigus is a rare autoimmune disease during pregnancy. Among the different pemphigus types, pemphigus foliaceus (PF) is even rarer than pemphigus vulgaris. We present a case of PF in a 36-year-old female patient who presented with PF onset during pregnancy in the form of a disseminated, erythematosquamous rash. Read More

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New biochip immunofluorescence test for the serological diagnosis of pemphigus vulgaris and foliaceus: A review of the literature.

Int J Womens Dermatol 2018 Jun 3;4(2):102-108. Epub 2018 Feb 3.

Department of Dermatology, St George Hospital, Sydney, New South Wales, Australia.

The immunoassays that are available for the serological diagnosis of the more common subtypes of autoimmune blistering diseases such as pemphigus vulgaris (PV) and pemphigus foliaceus (PF) include enzyme-linked immunosorbent assay (ELISA) testing to specific antigens desmoglein (Dsg)1 and Dsg3, direct immunofluorescence (DIF), indirect immunofluorescence (IIF), and immunoblotting. A review of the literature on the biochip assay was conducted. Six studies investigated the validity of a new biochip, mosaic-based, IIF test in patients with pemphigus and demonstrated its relatively high sensitivity and specificity (Dsg3: 97. Read More

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Clinical and Immunological Study of 30 Cases With Both IgG and IgA Anti-Keratinocyte Cell Surface Autoantibodies Toward the Definition of Intercellular IgG/IgA Dermatosis.

Front Immunol 2018 7;9:994. Epub 2018 May 7.

Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan.

Several sporadic cases, in which direct and indirect immunofluorescence studies simultaneously detected IgG and IgA autoantibodies to keratinocyte cell surfaces, have been reported mainly under the name of IgG/IgA pemphigus. However, there have been no systematic studies for this condition. In this study, we collected 30 cases of this condition from our cohort of more than 5,000 autoimmune bullous disease cases, which were consulted for our diagnostic methods from other institutes, and summarized their clinical and immunological findings. Read More

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May 2018
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[Pemphigus and herpes: Multicentre survey and literature review].

Ann Dermatol Venereol 2018 Jun 1. Epub 2018 Jun 1.

Service de dermatologie, hôpital Henri-Mondor, Assistance publique-Hôpitaux de Paris (AP-HP), 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France; Centre de référence des maladies bulleuses auto-immunes MALIBUL, 76000 Rouen France. Electronic address:

Background: Although herpes superinfection is a well-known complication of pemphigus, it has not been widely investigated.

Aim: To investigate the frequency and features of herpes infection in patients with ongoing pemphigus.

Patients And Methods: We carried out a multicenter retrospective study between 2008 and 2016 in patients with newly diagnosed pemphigus presenting active herpes infection. Read More

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A Case of Hailey-Hailey Disease Managed With Oral Magnesium Citrate and High-Dose Vitamin D.

J Cutan Med Surg 2018 May/Jun;22(3):362-364

1 Section of Dermatology, Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Hailey-Hailey disease, or benign familial pemphigus, is a rare blistering disease originally described in 1939. The disease is due to an autosomal dominant mutation in the ATP2C1 gene on chromosome 3, which encodes for an adenosine triphosphate-dependent calcium pump in the Golgi apparatus whose function is to maintain intercellular calcium homeostasis. Common treatments for Hailey-Hailey disease involve calcineurin inhibitors, topical corticosteroids, topical or systemic antibiotics, topical antifungals, ablative lasers, or botulin toxin. Read More

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June 2018
5 Reads

Elevated serum eosinophil cationic protein and transforming growth factor-α levels in a patient with pemphigus vegetans.

Clin Exp Dermatol 2018 Jun 4. Epub 2018 Jun 4.

Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.

Pemphigus vegetans (PVeg) is a rare variant of pemphigus, characterized by vegetating lesions mainly with antidesmoglein 3 antibodies. However, the pathomechanisms for PVeg is still unknown. We present a patient with PVeg mainly associated with antidesmocollin (Dsc)3 antibodies, who originally developed pemphigus foliaceus. Read More

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Italian guidelines in pemphigus. Adapted from the European Dermatology Forum (EDF) and European Academy of Dermatology And Venerology (EADV).

G Ital Dermatol Venereol 2018 May 31. Epub 2018 May 31.

Clinica Dermatologica, Università di Brescia, Brescia, Italy.

Pemphigus is a life threatening autoimmune epidermal blistering disease involving skin and mucous membranes. Pemphigus usually affects middle age men and women involving oral mucosa first and then spreading on the skin. It is caused by the presence of autoantibodies (IgG and less frequently by IgA) directed against desmogleins, and/or other glycoproteins that plays a critical role in cell-cell attachment. Read More

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A rare case with prominent features of both discoid lupus erythematosus and pemphigus foliaceus.

J Eur Acad Dermatol Venereol 2018 Jun 2. Epub 2018 Jun 2.

Department of Dermatology, Center for Blistering Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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June 2018
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Association study and fine-mapping major histocompatibility complex analysis of pemphigus vulgaris in a Han Chinese population.

J Invest Dermatol 2018 May 29. Epub 2018 May 29.

Department of Dermatology, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230022, China; Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032,China; State Key Lab of Dermatology Incubation Center, Anhui Medical University, Hefei, Anhui Province, 230032,China; Anhui Province key Laboratory of Major Autoimmune Disease, Anhui Medical University, Hefei, Anhui 230032, China. Electronic address:

To identify possible additional genetic susceptibility loci for pemphigus vulgaris (PV), we performed a genome-wide association study (GWAS) of 240 PV cases and 1,031 controls, and we selected the top single nucleotide polymorphisms (SNPs) for replication in independent samples, with 252 cases and 1,852 controls. We identified rs11218708 (P= 3.1 × 10, OR=1. Read More

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Association between climate, pollution and hospitalization for pemphigus in the USA.

Clin Exp Dermatol 2018 Jun 1. Epub 2018 Jun 1.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: Little is known about the impact of ultraviolet exposure, climate factors and pollutants on pemphigus.

Aim: To determine whether these factors are associated with pemphigus exacerbation resulting in hospitalization.

Methods: The analysis used data from the 2002-2012 National Inpatient Sample in the USA, including 68 476 920 children and adults, and measurements of relative humidity (%), ultraviolet (UV) index, outdoor air temperature and particulate matter of ≤ 2. Read More

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Study of Extrinsic Apoptotic Pathway in Oral Pemphigus Vulgaris Using TNFR 1 and FasL Immunohistochemical Markers and TUNEL Technique.

J Dent (Shiraz) 2018 Jun;19(2):132-141

Postgraduate Student, Dental Research Center, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.

Statement Of The Problem: Pemphigus vulgaris is characterized by intraepithelial vesicles, but pathogenesis of vesicle formation in this disease has not been substantiated yet.

Purpose: The present study investigate extrinsic apoptotic pathway in oral pemphigus vulgaris using TUNEL and important immunohistochemical markers of extrinsic pathway, TNFR1 and FasL.

Materials And Method: In the present cross sectional study, 25 oral pemphigus vulgaris samples and 6 normal oral mucosa were analyzed for the presence of apoptosis by TUNEL and the staining of TNFR1 and FasL in basal and parabasal layers around vesicle, vesicle floor, vesicle roof and acantholytic cells. Read More

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Facilitated subcutaneous immunoglobulin treatment in pemphigus vulgaris.

BMJ Case Rep 2018 May 30;2018. Epub 2018 May 30.

Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases, Coordinating Center of Piemonte and Valle d'Aosta Network for Rare Diseases, S. Giovanni Bosco Hospital, Turin, Italy.

A novel administration strategy of immunoglobulin treatment is represented by injection of recombinant human hyaluronidase (rHUPH20) with subcutaneous immunoglobulins. The use of facilitated subcutaneous immunoglobulin treatment (fSCIG) for the treatment of autoimmune conditions is yet to be investigated. We present the case of a 56-year-old female patient with pemphigus vulgaris predominantly of the oral mucous membranes, previously treated for 24 months with azathioprine and medium doses of steroids, with only partial remission. Read More

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May 2018
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Paraneoplastic pemphigus in Russian patients: a single center case series.

Int J Dermatol 2018 May 24. Epub 2018 May 24.

Division of Immune-mediated Skin Diseases, Department of Dermatology and Venereology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

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May 2018
5 Reads

A rare case of Pemphigus Herpetiformis in a young woman.

G Ital Dermatol Venereol 2018 May 16. Epub 2018 May 16.

Department of Dermatology, Policlinic Vittorio Emanuele Hospital, Catania, Italy -

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Pemphigus foliaceus and acquired haemophilia: a rare but important association with life-threatening consequences.

Clin Exp Dermatol 2018 May 19. Epub 2018 May 19.

Department of Dermatology, University Hospitals Coventry and Warwickshire NHS Foundation TrustCoventry, Clifford Bridge Road, CV2 2DX, UK.

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Paraneoplastic pemphigus foliaceus related to underlying breast cancer.

Clin Exp Dermatol 2018 May 16. Epub 2018 May 16.

Department of Dermatology, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK.

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The Significance of Scalp Involvement in Pemphigus: A Literature Review.

Biomed Res Int 2018 25;2018:6154397. Epub 2018 Mar 25.

Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.

Scalp is a unique location for pemphigus because of the abundance of desmogleins localized in hair follicles. Scalp involvement is observed in up to 60% of patients in the course of pemphigus. The lesions may occasionally lead to alopecia. Read More

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Patients affected by a new variant of endemic pemphigus foliaceus have autoantibodies colocalizing with MYZAP, p0071, desmoplakins 1-2 and ARVCF, causing renal damage.

Clin Exp Dermatol 2018 May 16. Epub 2018 May 16.

Department of Clinical Laboratory and Pathology, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia.

Background: We have previously reported that about 30% of patients affected by a new variant of endemic pemphigus foliaceus (EPF) in El Bagre, Colombia (termed El Bagre-EPF or pemphigus Abreu-Manu) have systemic compromise. In the current study, we focused on studying autoreactivity to the kidney and its pathological correlations.

Aim: To investigate patients with El Bagre-EPF for renal compromise. Read More

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May 2018
4 Reads
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Unique causes of esophageal inflammation: a histopathologic perspective.

Ann N Y Acad Sci 2018 May 16. Epub 2018 May 16.

Department of Pathology, Yale School of Medicine, New Haven, Connecticut.

Gastroenterologists frequently perform endoscopic esophageal mucosal biopsies for pathologic diagnosis in patients experiencing symptoms of esophagitis. The more common causes of esophagitis diagnosed on esophageal mucosal biopsy include reflux esophagitis, eosinophilic esophagitis, and infectious esophagitis caused by Candida albicans, herpes simplex virus, and/or cytomegalovirus. However, there are several causes of esophagitis seen less frequently by pathologists that are very important to recognize. Read More

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May 2018
3 Reads

Lichenoid paraneoplastic pemphigus associated with follicular lymphoma without detectable autoantibodies.

Clin Exp Dermatol 2018 May 14. Epub 2018 May 14.

Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

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Autoantibody Signaling in Pemphigus Vulgaris: Development of an Integrated Model.

Front Immunol 2018 19;9:692. Epub 2018 Apr 19.

Department of Dermatology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, United States.

Pemphigus vulgaris (PV) is an autoimmune skin blistering disease effecting both cutaneous and mucosal epithelia. Blister formation in PV is known to result from the binding of autoantibodies (autoAbs) to keratinocyte antigens. The primary antigenic targets of pathogenic autoAbs are known to be desmoglein 3, and to a lesser extent, desmoglein 1, cadherin family proteins that partially comprise the desmosome, a protein structure responsible for maintaining cell adhesion, although additional autoAbs, whose role in blister formation is still unclear, are also known to be present in PV patients. Read More

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Auto-immune skin diseases in animals: time to reclassify and review after 40 years.

Authors:
Thierry Olivry

BMC Vet Res 2018 May 11;14(1):157. Epub 2018 May 11.

Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606, USA.

It has been more than 40 years since the dual descriptions of canine pemphigus vulgaris. Over the ensuing four decades, the reports of-mostly canine-novel autoimmune skin diseases (AISDs) have progressed in successive waves separated by long periods of quiescence. This Editorial introduces a series of comprehensive review papers on the various canine and feline AISDs. Read More

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May 2018
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Auftreten einer Psoriasis vulgaris bei einem Patienten mit Pemphigus vulgaris unter Kortikosteroidtherapie.

J Dtsch Dermatol Ges 2018 May;16(5):605-607

Department of Dermatology, National Defense Medical College, Tokorozawa, Saitama, Japan.

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Increased expression of microRNA-338-3p contributes to production of Dsg3 antibody in pemphigus vulgaris patients.

Mol Med Rep 2018 Apr 26. Epub 2018 Apr 26.

Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.

Expression of microRNA-338-3p (miR-338-3p) was aberrantly elevated in pemphigus vulgaris (PV), although its role in PV is still unknown. The present study investigated the functional role and possible molecular mechanisms of miR-338-3p in PV. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was performed to detect miR-338-3p expression in peripheral blood mononuclear cells (PBMCs) from patients with PV. Read More

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Keratinocyte Binding Assay Identifies Anti-Desmosomal Pemphigus Antibodies Where Other Tests Are Negative.

Front Immunol 2018 24;9:839. Epub 2018 Apr 24.

Department of Dermatology, University of Groningen, University Medical Center Groningen, Center for Blistering Diseases, Groningen, Netherlands.

The serological diagnosis of pemphigus relies on the detection of IgG autoantibodies directed against the epithelial cell surface by indirect immunofluorescence (IIF) on monkey esophagus and against desmoglein 1 (Dsg1) and Dsg3 by ELISA. Although being highly sensitive and specific tools, discrepancies can occur. It is not uncommon that sera testing positive by ELISA give a negative result by IIF and . Read More

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April 2018
2 Reads

Emerging treatment options for the management of pemphigus vulgaris.

Authors:
Khalaf Kridin

Ther Clin Risk Manag 2018 27;14:757-778. Epub 2018 Apr 27.

Department of Dermatology, Rambam Health Care Campus, Haifa, Israel.

Pemphigus vulgaris (PV) is a life-threatening disease belonging to the pemphigus group of autoimmune intra-epidermal bullous diseases of the skin and mucosae. The therapeutic management of PV remains challenging and, in some cases, conventional therapy is not adequate to induce clinical remission. The cornerstone of PV treatment remains systemic corticosteroids. Read More

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April 2018
2 Reads

Validity and reliability of the persian version of the chronic oral mucosal diseases questionnaire.

Caspian J Intern Med 2018 ;9(2):127-133

Department of Oral Medicine, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.

Background: Chronic oral mucosal disease uestionnaire (COMDQ) is used to evaluate the quality of life in patients with chronic conditions of the oral mucosa. The aim of the present study was to evaluate the validity and reliability of the Persian version of this questionnaire.

Methods: A total of 135 subjects were selected in two groups; group 1 consisted of 95 patients with chronic oral mucosal conditions, including recurrent aphthous stomatitis, oral lichen planus and pemphigus and mucous membrane pemphigoid and group 2 consisted of 40 patients with other oral diseases. Read More

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January 2018

Caspase cascade pathways of apoptosis in oral pemphigus: An immunohistochemical study.

J Oral Maxillofac Pathol 2018 Jan-Apr;22(1):48-53

Department of Dentistry, DM WIMS, Wayanad, Kerala, India.

Background: Pemphigus is a group of autoimmune blistering diseases characterized by loss of keratinocyte cell adhesion that leads to blister formation clinically. Induction of apoptosis or of proapoptotic proteins by pemphigus immunoglobulin G (IgG) may be part of the mechanism by which IgG induces acantholysis. Some of the current data suggest that activation of proapoptotic proteins such as bax and caspase cysteine proteinases may sensitize cells to the acantholytic effects of pemphigus IgG. Read More

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The effect of autoimmune blistering diseases on work productivity.

J Eur Acad Dermatol Venereol 2018 May 6. Epub 2018 May 6.

Department of Dermatology, St George Hospital, Sydney, NSW, Australia.

Background: Autoimmune blistering diseases (AIBD) are known to negatively impact upon quality of life (QoL); however, there is a paucity of research on the effect of AIBD on work productivity. AIBD can be quite disfiguring in terms of a patient's appearance due to their blistering nature.

Objective: To determine the impact of AIBD on work productivity and to determine whether patients are stigmatized at work due to their appearance. Read More

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Beta-adrenoceptor expression in pemphigus foliaceus.

J Eur Acad Dermatol Venereol 2018 May 6. Epub 2018 May 6.

MUHC - McGill University Ocular Pathology & Translational Research Laboratory, Montreal, QC, Canada.

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Autoimmune bullous diseases in non-HIV Kaposi's sarcoma: a retrospective study in a large cohort of patients.

J Eur Acad Dermatol Venereol 2018 May 5. Epub 2018 May 5.

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Unità Operativa di Dermatologia, IRCCS Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.

Background: Kaposi's sarcoma (KS) is a rare endothelial neoplasm caused by the human herpesvirus 8 (HHV-8). Its risk is increased in immunocompromised patients, including those undergoing immunosuppressive therapy for autoimmune bullous diseases. Conversely, HHV-8 infection has been hypothesized to be a triggering factor of bullous diseases, especially pemphigus. Read More

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May 2018
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Contact allergy caused by methylisothiazolinone in a mouthwash as the likely trigger of oral pemphigus vulgaris.

Contact Dermatitis 2018 May 4. Epub 2018 May 4.

Clinica Dermatologica, Department of Health Sciences (DiSSAL), Università di Genova, Ospedale Policlinico San Martino, Genoa, Italy.

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Oxidative stress in patients with endemic pemphigus foliaceus and healthy subjects with anti-desmoglein 1 antibodies.

An Bras Dermatol 2018 Mar;93(2):212-215

Department of Dermatology, Oregon Health & Science University, Oregon, USA.

Background: Previous studies have shown oxidative stress in pemphigus vulgaris and pemphigus foliaceus, nevertheless, it remains unknown whether a similar response is characteristic of endemic pemphigus foliaceus in Peru.

Objectives: To determine the oxidative stress response in endemic pemphigus foliaceus patients and subjects with positive for anti-desmoglein1 antibodies (anti-dsg1) from endemic areas of Peru.

Subjects And Methods: This is a cross-sectional study. Read More

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March 2018
1 Read