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    1 OF 190

    Hailey-Hailey disease due to ATP2C1 splice-site mutation, successfully treated with minocycline hydrochloride.
    J Eur Acad Dermatol Venereol 2017 Jun 27. Epub 2017 Jun 27.
    Departments of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.
    Hailey-Hailey disease (HHD) is an autosomal dominant disease characterized by acantholysis and caused by ATP2C1.(1) Here, we report the first case of HHD successfully treated with minocycline alone in which the diagnosis was confirmed by gene analysis. This article is protected by copyright. Read More

    Intraepidermal neutrophilic dermatosis type of IgA pemphigus with circulating linear IgA disease antibodies associated with ulcerative colitis.
    J Eur Acad Dermatol Venereol 2017 Jun 27. Epub 2017 Jun 27.
    Dept. of Dermatology and Allergy, Faculty of Medicine and Health Sciences, University of Oldenburg, Klinikum Oldenburg AöR.
    A 42-year-old woman with ulcerative colitis previously well controlled on mesalazine presented with blistering, crusts and severe itching on her upper body and legs together with painful erosions on her conjunctivae and oral mucous membranes in addition to active bowel symptoms for two weeks. Clinical examination revealed multiple lesions consisting of vesiculopustules with circinate distribution and central crusts in sunflower-like configuration on her flanks and legs, a typical characteristic of intraepidermal neutrophilic dermatosis (IEN)-type of IgA pemphigus (Figure 1A and 1C) [1]. Lips, nasolabial folds and eyelids were affected by yellow crusts and erosions on erythematous base (Figure 1B). Read More

    Pivotal Role of Lesional and Perilesional T/B Lymphocytes in Pemphigus Pathogenesis.
    J Invest Dermatol 2017 Jun 21. Epub 2017 Jun 21.
    Department of Dermatology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
    Pemphigus is a skin and mucosal membrane-targeting autoimmune bullous disease. Previous studies have demonstrated that circulating anti-desmoglein1/3 antibodies are pathogenic and mediate blister formation. However, the role of infiltrated immune cells in the lesional skin has not been fully investigated. Read More

    Rituximab administration in a patient with pemphigus vulgaris following reactivation of occult hepatitis B virus infection.
    Dermatol Online J 2017 Jun 20;23(6). Epub 2017 Jun 20.
    Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Immunosuppressive drugs are the milestone of treatment of autoimmune diseases, but they can lead to serious complications, including hepatitis B virus reactivation in HBV carriers as well as in patients with occult HBV infection (OBI). A 36-year-old man with OBI was diagnosed with pemphigus vulgaris. He was prescribed prednisolone and his hepatitis B surface antigen turned positive. Read More

    Rituximab in the management of juvenile pemphigus foliaceus.
    Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.
    School of Medicine, University of California San Diego, La Jolla, California.
    BackgroundPemphigus foliaceus (PF) is a blistering disorder most commonly presenting in middle age. As PF is restricted to the superficial epidermis, it is considered more benign than other pemphigus diseases. However, progression to severe disease is not uncommon. Read More

    Miniaturization of sebaceous glands - a novel histopathological finding in pemphigus vulgaris and pemphigus foliaceus of the scalp.
    J Cutan Pathol 2017 Jun 20. Epub 2017 Jun 20.
    Department of Dermatology, Medical University of Warsaw, Koszykowa 82a, 02-008, Warsaw, Poland.
    Background: Intraepidermal acantholysis is a characteristic histopathological feature of pemphigus. The histopathology of scalp biopsies in pemphigus has not been widely discussed in the literature, although the scalp is commonly involved in pemphigus.

    Methods: A total of 32 consecutive patients with scalp involvement (seventeen with pemphigus vulgaris and fifteen with pemphigus foliaceus) were enrolled into the study. Read More

    Rituximab treatment in pemphigus vulgaris: effect on circulating Tregs.
    Arch Dermatol Res 2017 Jun 19. Epub 2017 Jun 19.
    Department of Dermatology, Faculty of Medicine Cairo University, Kasr Al Ainy Hospital, Al-Manial, Cairo, 11956, Egypt.
    Rituximab (RTX) has been used successfully to treat refractory pemphigus. We aimed to assess the response of pemphigus vulgaris (PV) cases to RTX therapy and its effect on CD4(+)CD25(+) (T regulatory) cells level. Sixteen PV patients were included in this study, each received one cycle of two RTX infusions (1000 mg on days 1 and 15). Read More

    Paraneoplastic pemphigus in two pairs of brothers.
    J Eur Acad Dermatol Venereol 2017 Jun 16. Epub 2017 Jun 16.
    Department of Dermatology, Medical University of Graz, Austria.
    A 65-year-old man (Patient 1A) presented with erosions on the face, upper trunk and the oral mucosa in 1995 (Table 1). He underwent prostatectomy for prostate cancer in 1990. PNP was proven by antibodies to IgG anti-epithelial cell surface (ECS), desmoglein (Dsg)1, and Dsg3. Read More

    Different signaling patterns contribute to loss of keratinocyte cohesion dependent on autoantibody profile in pemphigus.
    Sci Rep 2017 Jun 15;7(1):3579. Epub 2017 Jun 15.
    Institute of Anatomy and Cell Biology, Ludwig-Maximilians-Universität München, Munich, 80336, Germany.
    Pemphigus is an autoimmune blistering skin disease caused primarily by autoantibodies against desmoglein (Dsg)1 and 3. Here, we characterized the mechanisms engaged by pemphigus IgG from patients with different clinical phenotypes and autoantibody profiles. All pemphigus vulgaris (PV) and pemphigus foliaceus (PF) IgG and AK23, a monoclonal mouse antibody against Dsg3, caused loss of cell cohesion, cytokeratin retraction and p38MAPK activation. Read More

    Possible triggering factors and comorbidities in newly diagnosed autoimmune bullous diseases.
    Turk J Med Sci 2017 Jun 12;47(3):832-840. Epub 2017 Jun 12.
    Department of Dermatology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey.
    Background/aim: The distribution and the demographic, etiological, and clinical features of autoimmune bullous diseases (ABDs) vary according to geographic regions of the world. The limited number of reported studies in Turkey are mostly retrospective and generally include only pemphigus. The aim of our study was to evaluate the demographic data, clinical features, associated triggering factors, and comorbidities in patients newly diagnosed with ABDs. Read More

    Robust memory responses against influenza vaccination in pemphigus patients previously treated with rituximab.
    JCI Insight 2017 Jun 15;2(12). Epub 2017 Jun 15.
    Department of Pediatrics, Division of Infectious Disease.
    Rituximab is a therapeutic anti-CD20 monoclonal antibody widely used to treat B cell lymphoma and autoimmune diseases, such as rheumatic arthritis, systemic lupus erythematosus, and autoimmune blistering skin diseases (AIBD). While rituximab fully depletes peripheral blood B cells, it remains unclear whether some preexisting B cell memory to pathogens or vaccines may survive depletion, especially in lymphoid tissues, and if these memory B cells can undergo homeostatic expansion during recovery from depletion. The limited data available on vaccine efficacy in this setting have been derived from rituximab-treated patients receiving concomitant chemotherapy or other potent immunosuppressants. Read More

    Recurrent Paronychia as a Presenting Manifestation of Pemphigus Vulgaris: A Case Report.
    Skin Appendage Disord 2017 Mar 19;3(1):28-31. Epub 2017 Jan 19.
    Skin Disease Centre, Nashik, India.
    Nail involvement in pemphigus vulgaris (PV) is an unusual clinical finding. The most common clinical manifestations include chronic paronychia and onychomadesis. We report an adult female patient with PV who initially presented with chronic paronychia of multiple fingernails and toenails before the onset of vesiculobullous eruptions. Read More

    Correlation between IL36α and IL17 and Activity of the Disease in Selected Autoimmune Blistering Diseases.
    Mediators Inflamm 2017 10;2017:8980534. Epub 2017 May 10.
    Department of Immunopathology, Chair of Allergy, Immunology and Dermatology, Medical University of Lodz, Lodz, Poland.
    Dermatitis herpetiformis (DH), bullous pemphigoid (BP), and pemphigus vulgaris (PV) are autoimmune bullous skin conditions with eosinophilic and neutrophilic infiltrations. While cytokines are crucial for the affinity and activation of different leukocyte cells in the inflammation and blister formation, there are no studies concerning a role of IL-36. The goal of the study was to analyze whether interleukin 36 is involved in pathogenesis of DH, BP, and PV. Read More

    An alternative pathway to eusociality: Exploring the molecular and functional basis of fortress defense.
    Evolution 2017 Jun 13. Epub 2017 Jun 13.
    Department of Biological Sciences, Vanderbilt University, Nashville, TN, 37235.
    Some animals express a form of eusociality known as 'fortress defense', in which defense rather than brood care is the primary social act. Aphids are small plant-feeding insects, but like termites, some species express division of labor and castes of aggressive juvenile 'soldiers'. What is the functional basis of fortress defense eusociality in aphids? Previous work showed that the acquisition of venoms might be a key innovation in aphid social evolution. Read More

    Blocking RhoA/ROCK inhibits the pathogenesis of pemphigus vulgaris by suppressing oxidative stress and apoptosis through TAK1/NOD2-mediated NF-κB pathway.
    Mol Cell Biochem 2017 Jun 12. Epub 2017 Jun 12.
    Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, NO. 91 Tianchi Road, Urumchi, 830001, Xinjiang Uygur Autonomous Region, People's Republic of China.
    Oxidative stress and apoptosis play critical roles in pemphigus vulgaris (PV). The main aim of the present study was to investigate the effects of RhoA/ROCK signaling on UVB-induced oxidative damage, and to delineate the molecular mechanisms involved in the UVB-mediated inflammatory and apoptotic response. In HaCaT cells, we observed that blockage of RhoA/ROCK signaling with the inhibitor CT04 or Y27632 greatly inhibited the UVB-mediated increase in intracellular reactive oxygen species (ROS). Read More

    Inhibition of p38MAPK signaling prevents epidermal blistering and alterations of desmosome structure induced by pemphigus autoantibodies in human epidermis.
    Br J Dermatol 2017 Jun 10. Epub 2017 Jun 10.
    Institute of Anatomy and Cell Biology, Department I, Ludwig-Maximilians-Universität (LMU) München, Germany.
    Background: Pemphigus vulgaris (PV) is a skin blistering disease caused by autoantibodies targeting the desmosomal adhesion proteins desmoglein (Dsg) 3 and 1. The mechanisms underlying pemphigus skin blistering are not fully elucidated but p38MAPK activation is one of the signaling events necessary for full loss of cell cohesion. However, it is unclear whether ultrastructural hallmarks of desmosome morphology as observed in patients' lesions are mediated by p38MAPK signaling. Read More

    Naringenin protects keratinocytes from oxidative stress injury via inhibition of the NOD2-mediated NF-κB pathway in pemphigus vulgaris.
    Biomed Pharmacother 2017 Aug 4;92:796-801. Epub 2017 Jun 4.
    Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China. Electronic address:
    Naringenin is known to have anti-oxidative activity; however, the effect of naringenin on the progression of pemphigus vulgaris (PV) still remains unclear. This study aims to analyze the effect of naringenin on HaCaT cell apoptosis and oxidative damage under the treatment of PV serum. The results showed that PV serum significantly induced cell apoptosis compared with the control group; whereas, comparing with PV group, naringenin inhibited cell apoptosis. Read More

    [Safety and efficacy of off-label use of biologic therapies in patients with inflammatory rheumatic diseases refractory to standard of care therapy : Data from a nationwide German registry (GRAID2)].
    Z Rheumatol 2017 Jun 6. Epub 2017 Jun 6.
    Medizinische Klinik m.S. Rheumatologie und Klinische Immunologie, Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Deutschland.
    Background: The German Registry of Autoimmune Diseases 2 (GRAID2) is a retrospective, non-interventional, multicenter registry study collecting data from patients with inflammatory, mainly rheumatic diseases refractory to standard of care therapy and treated with an off-label biologic therapy. The retrospective documentation comprised case history, diagnosis, course of disease (including safety and global efficacy). The objective was to evaluate the global clinical outcome and safety of off-label biologic therapy in clinical practice. Read More

    Shifting Focus in the Therapeutics of Immunobullous Disease.
    Indian J Dermatol 2017 May-Jun;62(3):282-290
    Senior Resident, KPC Medical College, Kolkata, West Bengal, India.
    Therapeutics of autoimmune bullous disease has seen a major shift of focus from more global immunosuppression to targeted immunotherapy. Anti CD 20 monoclonal antibody Rituximab revolutionized the therapeutics of autoimmune bullous disease particularly pemphigus. Though it is still being practiced off-label, evidences in the form of RCT and meta analysis are now available. Read More

    Counseling in Pemphigus.
    Indian J Dermatol 2017 May-Jun;62(3):279-281
    Department of Dermatology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
    Pemphigus is a chronic, potentially life threatening, autoimmune intraepidermal blistering disease affecting the skin and the mucous membrane. Pemphigus may have profound impact on the quality of life in the affected patients. Counselling and adjuvant psychotherapy may be beneficial at least in few patients and should be considered as a part of multidisciplinary approach. Read More

    Pathophysiology of Autoimmune Bullous Diseases: Nature Versus Nurture.
    Indian J Dermatol 2017 May-Jun;62(3):262-267
    Department of Dermatology, University of California Davis, Sacramento, CA, USA.
    Pemphigus and pemphigoid are the prototypical immunobullous diseases. Although it has been well established that they are caused by deposition of autoreactive antibodies directed against adherence proteins within the skin, the specific genetic and environmental factors leading to development of these diseases continue to be an area of investigation. Herein, we discuss several of the potential environmental triggers that may induce patients to develop immunobullous diseases including medications, viral infections, UV exposure or other radiation injury and dietary factors. Read More

    Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus.
    Int J Med Microbiol 2017 May 29. Epub 2017 May 29.
    Department of Experimental Biology, Faculty of Science, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic.
    Exfoliative toxin B (ETB) encoded by some large plasmids plays a crucial role in epidermolytic diseases caused by Staphylococcus aureus. We have found as yet unknown types of etb gene-positive plasmids isolated from a set of impetigo strains implicated in outbreaks of pemphigus neonatorum in Czech maternity hospitals. Plasmids from the strains of clonal complex CC121 were related to archetypal plasmid pETBTY4. Read More

    Rituximab: A Magic Bullet for Pemphigus.
    J Clin Diagn Res 2017 Apr 1;11(4):WC01-WC06. Epub 2017 Apr 1.
    Senior Resident, Department of Dermatovenereology, Govt. Royapettah Hospital, Chennai, Tamil Nadu, India.
    Introduction: Pemphigus, an autoimmune disease, was fatal before the era of corticosteroids. With the advent of steroids, mortality decreased but morbidity was present due to the side effects of high dose steroids. Newer drugs targeted at the molecular level are said to have fewer side effects and improved effectiveness. Read More

    The Rare Case of Pemphigus Vegetans in Association with Malnutrition Children in the Multidisciplinary Management.
    Case Rep Dermatol 2017 Jan-Apr;9(1):145-150. Epub 2017 Apr 27.
    Division of Allergy-Immunology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
    Pemphigus vegetans is a clinical variant of pemphigus vulgaris, accounting for 1-2% of all very rare pemphigus cases in children. The involvement of the oral mucosa in this disease is usually accompanied by severe pain that aggravates the patient's malnourished condition. Conversely, malnutrition may also reduce vulnerability towards autoimmune diseases. Read More

    Atypical Clinical and Serological Manifestation of Pemphigus Vegetans: A Case Report and Review of the Literature.
    Case Rep Dermatol 2017 Jan-Apr;9(1):121-130. Epub 2017 Apr 27.
    aDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
    Pemphigus vegetans (PVeg) is a rare variant of pemphigus vulgaris characterized by pustules and/or papillomatous vegetations, preferentially affecting intertriginous and periorificial areas. Exceptional manifestations may be misdiagnosed resulting in delayed diagnosis and treatment. Diagnosis is confirmed by immunofluorescence and detection of anti-desmoglein (Dsg) 3 and/or anti-Dsg1 antibodies. Read More

    Pemphigus vulgaris induced by 5-aminolaevulinic acid-based photodynamic therapy.
    Photodiagnosis Photodyn Ther 2017 May 22. Epub 2017 May 22.
    Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, PR China. Electronic address:
    Pemphigus vulgaris (PV) is an autoimmune disorder resulting from the interaction between autoantibodies and desmoglein. Here, we report a case of PV developed after 5-aminolaevulinic acid-based photodynamic therapy (ALA-PDT). The harmful and deleterious effects of UV radiation on the onset, during course, and perpetuation of PV have been observed for decades. Read More

    Correlation between salivary and serum anti-desmoglein 1 and 3 antibody titres using ELISA and between anti-desmoglein levels and disease severity in pemphigus vulgaris.
    Clin Exp Dermatol 2017 May 22. Epub 2017 May 22.
    Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    ELISA for anti-desmoglein antibodies (Dsg) is commonly used for diagnosis and assessment of treatment response in pemphigus vulgaris (PV). The present study was conducted to assess the relationship between salivary and serum Dsg1 and Dsg3 levels, and whether salivary Dsg1 and Dsg3 levels correlate with clinical disease severity of oral mucosal lesions in PV. In total 43, patients with PV with predominantly mucosal involvement were recruited. Read More

    Pemphigus Vulgaris and Pemphigus Foliaceus: Differences in Epidemiology and Mortality.
    Acta Derm Venereol 2017 May 24. Epub 2017 May 24.
    Department of Dermatology, Rambam Health Care Campus, POB 9602, 31096 Haifa, Israel.
    Little is known about differences in epidemiological features and prognosis between pemphigus vulgaris (PV) and pemphigus foliaceus (PF). The objective of this study was to compare PV and PF patients regarding ethnic variations and mortality rates. Mortality of PV and PF patients was compared with age- and gender-matched control subjects in the general population. Read More

    Gastrointestinal cytomegalovirus disease in a patient with pemphigus vulgaris treated with corticosteroid and mycophenolate mofetil.
    Autops Case Rep 2017 Jan-Mar;7(1):23-30. Epub 2017 Mar 30.
    Autopsy Division - Anatomic Pathology Department - Faculty of Medicine - Universidade de São Paulo, São Paulo/SP - Brazil.
    Pemphigus vulgaris is an autoimmune disease characterized by the formation of suprabasal intra-epidermal blisters on the skin and mucosal surfaces. Infectious diseases are the main cause of death in patients with pemphigus due to the disrupture of the physiological skin barrier, immune dysregulation, and the use of immunosuppressive medications leaving the patient prone to acquire opportunistic infections. We report the case of a 67-year-old woman diagnosed with pemphigus vulgaris, who was irregularly taking prednisone and mycophenolate mofetil. Read More

    CD59 polymorphisms are associated with gene expression and different sexual susceptibility to pemphigus foliaceus.
    Autoimmunity 2017 May 23:1-9. Epub 2017 May 23.
    a Laboratory of Human Molecular Genetics, Department of Genetics , Universidade Federal do Paraná , Curitiba , Brazil.
    Pemphigus foliaceus (PF) is an autoimmune disease, endemic in Brazilian rural areas, characterized by acantholysis and accompanied by complement activation, with generalized or localized distribution of painful epidermal blisters. CD59 is an essential complement regulator, inhibiting formation of the membrane attack complex, and mediating signal transduction and activation of T lymphocytes. CD59 has different transcripts by alternative splicing, of which only two are widely expressed, suggesting the presence of regulatory sites in their noncoding regions. Read More

    Association Between Inflammatory Skin Disease and Cardiovascular and Cerebrovascular Co-Morbidities in US Adults: Analysis of Nationwide Inpatient Sample Data.
    Am J Clin Dermatol 2017 May 22. Epub 2017 May 22.
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Suite 1600, 676 N. St. Clair St., Chicago, IL, 60611, USA.
    Background: Psoriasis, atopic dermatitis or eczema (AD-E), pemphigus, bullous pemphigoid (BP), and hidradenitis are chronic inflammatory skin disorders associated with systemic immune activation, considerable symptom burden, stigma, functional disturbances, and mental health symptoms. All of these might increase cardiovascular risk.

    Objective: The objective of this study was to determine whether these inflammatory skin diseases are associated with increased cardiovascular/cerebrovascular risk and/or disease. Read More

    Pediatric Pemphigus Herpetiformis: Case Report and Review of the Literature.
    Pediatr Dermatol 2017 May;34(3):342-346
    Dermatology Program, Division of Immunology and Allergy, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
    Pemphigus herpetiformis (PH) is a rare autoimmune bullous condition usually seen in adults and likely underrecognized in children. We describe a 2-year-old girl who presented with a chronic, generalized, blistering rash consistent with pediatric PH based on histology and immunohistochemistry and review the literature. Prognosis is generally more favorable in children than adults. Read More

    Identification of factors associated with treatment refractoriness of oral lesions in pemphigus vulgaris.
    Br J Dermatol 2017 May 12. Epub 2017 May 12.
    Department of Virology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: Oral mucosal lesions of pemphigus vulgaris (PV) are known to show more treatment refractoriness than skin lesions.

    Objectives: To identify the role of different clinical and laboratory parameters in the treatment refractoriness in the oral lesions of PV.

    Methods: This prospective study recruited 50 adult patients of PV having oral lesions. Read More

    Case of shift from linear immunoglobulin A bullous dermatosis to pemphigus herpetiformis for a short period of time.
    J Dermatol 2017 Feb 5;44(2):189-193. Epub 2016 Nov 5.
    Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.
    Pemphigus herpetiformis (PH) is a rare variant of pemphigus characterized by erythemas and vesicles, tending to present with annular-shaped lesions. Immunologically, immunoglobulin (Ig)G deposition at the keratinocyte cell surfaces is observed. Linear IgA bullous dermatosis (LABD) is a rare subepidermal blistering disease with linear IgA deposits at the epidermal basement membrane zone (BMZ). Read More

    Venous thromboembolism in patients with pemphigus: A cohort study.
    J Am Acad Dermatol 2017 May 8. Epub 2017 May 8.
    Department of Dermatology, Beilinson Hospital, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Venous thromboembolism (VTE) has been reported to be a significant cause of death in patients with pemphigus.

    Objective: We sought to assess the incidence and characteristics of VTE in patients with pemphigus.

    Methods: A retrospective study following a cohort of 172 patients with newly diagnosed pemphigus for the development of VTE was conducted. Read More

    Pemphigus.
    Nat Rev Dis Primers 2017 May 11;3:17026. Epub 2017 May 11.
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
    Pemphigus is a group of IgG-mediated autoimmune diseases of stratified squamous epithelia, such as the skin and oral mucosa, in which acantholysis (the loss of cell adhesion) causes blisters and erosions. Pemphigus has three major subtypes: pemphigus vulgaris, pemphigus foliaceus and paraneoplastic pemphigus. IgG autoantibodies are characteristically raised against desmoglein 1 and desmoglein 3, which are cell-cell adhesion molecules found in desmosomes. Read More

    Validation studies of outcome measures in pemphigus.
    Int J Womens Dermatol 2016 Dec 10;2(4):128-139. Epub 2016 Dec 10.
    Department of Dermatology, St. George Hospital, Sydney, Australia.
    Pemphigus is a group of rare and potentially fatal autoimmune blistering diseases that are associated with auto-antibodies that target intercellular adhesion molecules. Incidence of pemphigus varies among populations, with the lowest incidence in Switzerland and Finland at 0.6-0. Read More

    Evaluation of prolactin levels in patients with newly diagnosed pemphigus vulgaris and its correlation with pemphigus disease area index.
    Int J Womens Dermatol 2016 Jun 23;2(2):53-55. Epub 2016 Apr 23.
    Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Prolactin is a hormone; in addition to it known roles, it has immunomodulatory effects on lymphocytes maturation and immunoglobulins production. Hyperprolactinemia has been demonstrated in various autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, type I diabetes mellitus, and Graves' disease. In view of the prolactin immunomodulatory roles, studying prolactin levels in pemphigus as an autoimmune blistering disease may introduce new ways of understanding disease etiology and developing treatment strategies. Read More

    Genetics-based interactions of foundation species affect community diversity, stability and network structure.
    Proc Biol Sci 2017 May;284(1854)
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA
    We examined the hypothesis that genetics-based interactions between strongly interacting foundation species, the tree Populus angustifolia and the aphid Pemphigus betae, affect arthropod community diversity, stability and species interaction networks of which little is known. In a 2-year experimental manipulation of the tree and its aphid herbivore four major findings emerged: (i) the interactions of these two species determined the composition of an arthropod community of 139 species; (ii) both tree genotype and aphid presence significantly predicted community diversity; (iii) the presence of aphids on genetically susceptible trees increased the stability of arthropod communities across years; and (iv) the experimental removal of aphids affected community network structure (network degree, modularity and tree genotype contribution to modularity). These findings demonstrate that the interactions of foundation species are genetically based, which in turn significantly contributes to community diversity, stability and species interaction networks. Read More

    Nasal, pharyngeal, and laryngeal pemphigus vulgaris successfully treated with rituximab.
    Ear Nose Throat J 2017 Apr-May;96(4-5):E35-E38
    University of Alabama at Birmingham, 1520 3rd Ave., South, EFH 414, Birmingham, AL 35294-0009, USA.
    Pemphigus vulgaris is a potentially fatal autoimmune blistering disease that can involve the nasopharyngeal and laryngeal tissues. The disease can be recalcitrant to conventional oral treatments, and treatment alternatives are limited. This retrospective study evaluated the efficacy of rituximab as a rescue agent in 5 patients with recalcitrant pemphigus vulgaris involving nasopharyngeal and laryngeal mucosa. Read More

    Immunofluorescence of Autoimmune Bullous Diseases.
    Surg Pathol Clin 2017 Jun 30;10(2):505-512. Epub 2017 Mar 30.
    Department of Dermatology, Center for Blistering Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
    Autoimmmune bullous diseases of skin and mucosa are uncommon, disabling, and potentially lethal diseases. For a quick and reliable diagnosis immunofluorescence is essential. This article describes two variants of immunofluorescence. Read More

    Biologics in patients with skin diseases.
    J Allergy Clin Immunol 2017 May;139(5):1423-1430
    Sunnybrook Health Sciences Centre and University of Toronto, Department of Medicine, Division of Dermatology, Toronto, Ontario, Canada. Electronic address:
    Biologic agents are important therapeutic options for treating multiple moderate-to-severe cutaneous diseases. Monoclonal antibodies already in use or under investigation are targeted for psoriasis, atopic dermatitis, melanoma, hidradenitis suppurativa, and pemphigus vulgaris. Read More


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