674 results match your criteria Pemphigus Paraneoplastic


Risk factors for death and survival in paraneoplastic pemphigus associated with hematologic malignancies in adults.

J Am Acad Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Assistance Publique-Hôpitaux de Paris, Département de Dermatologie, Hôpital Saint-Louis, Paris, France; Université Paris-Diderot, Sorbonne Paris Cité, Paris, France. Electronic address:

Background: Paraneoplastic pemphigus (PNP) occurs more often in patients with hematologic malignancies (HMs) than in patients with solid cancer. Lung bronchiolitis obliterans (BO) is a severe complication of PNP.

Objective: To determine the precise clinical and biologic features of HM-associated PNP and identify factors associated with mortality and survival. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.03.043DOI Listing
April 2019
1 Read

Review of paraneoplastic syndromes in children.

Pediatr Radiol 2019 Apr 16;49(4):534-550. Epub 2019 Mar 16.

Department of Radiology, Boston Children's Hospital, 300 Longwood Ave., Boston, MA, 02215, USA.

Paraneoplastic syndromes are defined as clinical syndromes that are not related to direct tumor invasion or compression but are secondary to tumor secretion of functional peptides/hormones or related to immune cross-reactivity with normal host tissue. Paraneoplastic syndromes have a wide range of presentations and can present before the primary malignancy or tumor recurrence is diagnosed. They can mimic non-neoplastic processes, making detection, diagnosis and treatment difficult. Read More

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http://dx.doi.org/10.1007/s00247-019-04371-yDOI Listing
April 2019
5 Reads

Cutaneous paraneoplastic syndromes.

Semin Diagn Pathol 2019 Jan 31. Epub 2019 Jan 31.

PRW Laboratories, Charlottesville, VA, United State.

A variety of cutaneous abnormalities can be seen in patients with malignant diseases, some of which are infectious, with others representing direct involvement of the skin by the underlying disorder. Yet another group of lesions can be regarded as associated markers of the malignant process, and, as such, are termed "paraneoplastic." This review considers the latter collection of conditions, grouping them by the generic type of malignancy that is usually linked to the paraneoplasia. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.01.001DOI Listing
January 2019
15 Reads

[Follicular lymphoma accompanied by paraneoplastic pemphigus and bronchiolitis obliterans: a case report].

Rinsho Ketsueki 2019;60(1):7-11

Department of Hematology, Tokyo Medical and Dental University.

A 54-year-old female complained of oral erosion. A flaccid blister appeared on the trunk 2 months after the onset. The high titer of the anti-desmoglein 1 antibody in the absence of Nikolsky's sign led to the diagnosis of pemphigus vulgaris. Read More

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http://dx.doi.org/10.11406/rinketsu.60.7DOI Listing
January 2019
3 Reads

Decreased recognition of paraneoplastic pemphigus in patients previously treated with anti-CD 20 monoclonal antibodies.

Br J Dermatol 2019 Jan 15. Epub 2019 Jan 15.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.

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http://dx.doi.org/10.1111/bjd.17577DOI Listing
January 2019
1 Read

A rare association of paraneoplastic pemphigus with gastric signet cell ring carcinoma.

Australas J Dermatol 2018 Dec 4. Epub 2018 Dec 4.

Division of Immune-Mediated Skin Diseases, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

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http://dx.doi.org/10.1111/ajd.12963DOI Listing
December 2018
5 Reads

Diagnosis of Autoimmune Blistering Diseases.

Front Med (Lausanne) 2018 2;5:296. Epub 2018 Nov 2.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

Autoimmune skin blistering diseases (AIBD) are characterized by autoantibodies that are directed against structural proteins in the skin and adjacent mucous membranes. Some clinical signs are typical for a specific AIBD, however, correct diagnosis requires the detection of tissue-bound or circulating autoantibodies. The gold standard for diagnosis of AIBD is the detection of autoantibodies or complement component 3 by direct immunofluorescence (DIF) microscopy of a perilesional biopsy. Read More

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http://dx.doi.org/10.3389/fmed.2018.00296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224342PMC
November 2018
22 Reads

Masked pemphigus among pediatric patients with Castleman's disease.

Int J Rheum Dis 2019 Jan 8;22(1):121-131. Epub 2018 Nov 8.

Department of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan.

Aim: Paraneoplastic pemphigus (PNP) is a mucocutaneous autoimmune disorder accompanied with a neoplasm. Castleman's disease (CD), although rare, is the most common cause of PNP in children. It can be life-threatening when pulmonary involvement occurs. Read More

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http://dx.doi.org/10.1111/1756-185X.13407DOI Listing
January 2019
24 Reads

Paraneoplastic pemphigus presenting lichen planus-like lesions.

J Dermatol 2019 Apr 14;46(4):e140-e142. Epub 2018 Sep 14.

Departments of Dermatology, Faculty of Medicine, Kindai University, Osaka-Sayama, Japan.

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http://dx.doi.org/10.1111/1346-8138.14639DOI Listing
April 2019
11 Reads

Pemphigus vulgaris as the first manifestation of multiple myeloma: a case report.

J Med Case Rep 2018 Sep 7;12(1):255. Epub 2018 Sep 7.

Department of Dermatology, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar.

Background: The association between pemphigus and malignancy has been well documented for decades but an association between pemphigus vulgaris and multiple myeloma is unusual. We report a case of pemphigus vulgaris revealing multiple myeloma.

Case Presentation: A 55-year-old Malagasy man, with no significant past medical history, presented with bullous and erosive skin lesions involving his trunk and scalp for the last 2 months. Read More

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http://dx.doi.org/10.1186/s13256-018-1791-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127896PMC
September 2018
11 Reads

Paraneoplastic pemphigus associated with chronic lymphocytic leukemia: a case report.

J Med Case Rep 2018 Aug 31;12(1):252. Epub 2018 Aug 31.

School of Health Sciences Dr. Paulo Prata (FACISB), Barretos, Sao Paulo, Brazil.

Background: Paraneoplastic pemphigus is a rare multiorgan disease of autoimmune causes, usually triggered by neoplasias, mainly of lymphoproliferative origin, such as leukemia and lymphoma. This disorder is categorized by the presence of autoantibodies that react against proteins, such as desmoplakins, desmogleins, desmocollins, and others that exist in cellular junctions. Paraneoplastic pemphigus can manifest clinically in a variety of ways, ranging from mucositis to lesions involving the skin and pulmonary changes. Read More

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http://dx.doi.org/10.1186/s13256-018-1742-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117874PMC
August 2018
5 Reads

Unicentric castleman disease complicated by paraneoplastic bronchiolitis obliterans and pemphigus.

Respir Med Case Rep 2018 10;25:129-132. Epub 2018 Aug 10.

Division of Pulmonary Medicine, Mayo Clinic Hospital, Phoenix, AZ, USA.

Bronchiolitis obliterans (BO) and paraneoplastic pemphigus are rare and ominous complications of Castleman disease. Collectively, these processes have been reported as part of paraneoplastic autoimmune multiorgan syndrome (PAMS), and they can occur in the setting of various hematologic malignant tumors, carcinoid tumors, and melanoma. Irrespective of the underlying malignancy driving PAMS, the clinical outcomes are uniformly poor, and there are no standard treatment regimens, given the clinical rarity of the syndrome. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098213PMC
August 2018
9 Reads

[Paraneoplastic pemphigus: Retrospective study of a case series].

Ann Dermatol Venereol 2018 Oct 17;145(10):564-571. Epub 2018 Aug 17.

Service de dermatologie, centre hospitalier régional universitaire de Brest, 2, avenue Foch, 29200 Brest, France. Electronic address:

Context: Paraneoplastic pemphigus (PNP) is a rare condition associated with poor prognosis. It associates polymorphic mucocutaneous manifestations with neoplasia. Diagnosis is difficult because of the various clinical and histological features involved and the lack of specificity of immunological examinations. Read More

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http://dx.doi.org/10.1016/j.annder.2018.01.050DOI Listing
October 2018
2 Reads

Paraneoplastic autoimmune multiorgan syndrome (PAMS): Beyond the single phenotype of paraneoplastic pemphigus.

Autoimmun Rev 2018 Oct 11;17(10):1002-1010. Epub 2018 Aug 11.

Department of Dermatology, University of California Irvine, Irvine, CA, USA; Institute for Immunology and Departments of Dermatology and Biological Chemistry, University of California, Irvine, CA, USA.

Paraneoplastic autoimmune multiorgan syndrome (PAMS) is characterized by a heterogenous group of signs and symptoms including severe desquamative stomatitis, a polymorphous cutaneous eruption, humoral immunity against plakin proteins, contribution of cell-mediated autoimmunity and commonly a progressive respiratory failure. Autoantibodies in PAMS target a wide array of antigens including plakins, cadherins, alpha-2-macroglobulin like 1 (A2ML1), BP180, plakophilin-3, and several neuromuscular antigens. Originally described as paraneoplastic pemphigus in 1990 due to some of its clinical and immunologic similarities to classic pemphigus (pemphigus vulgaris and pemphigus foliaceus), PAMS is a multiorganopathy with several distinct features from these classic forms of pemphigus. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.04.008DOI Listing
October 2018
3 Reads

Suprabasal acantholytic dermatologic toxicities associated checkpoint inhibitor therapy: A spectrum of immune reactions from paraneoplastic pemphigus-like to Grover-like lesions.

J Cutan Pathol 2018 Oct 24;45(10):764-773. Epub 2018 Jul 24.

Section of Dermatopathology, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas.

Checkpoint inhibitors (CPIs) restore the function of effector immunocytes to target and destroy cancer cells. Immune-related adverse events (irAEs) are a consequence of immune reactivation, with unpredictable inflammatory response, loss of self-tolerance, and development of autoimmunity. Adverse events from CPIs that present as dermatologic toxicities have diverse clinical and histopathologic features. Read More

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http://dx.doi.org/10.1111/cup.13312DOI Listing
October 2018
36 Reads

Paraneoplastic Pemphigus as a First Manifestation of an Intra-Abdominal Follicular Dendritic Cell Sarcoma: Rare Case and Review of the Literature.

Case Rep Oncol 2018 May-Aug;11(2):353-359. Epub 2018 May 31.

Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Background: Follicular dendritic cell sarcoma (FDCS) is an extremely rare malignant tumor caused by proliferation of antigen-presenting follicular dendritic cells. The tumor most commonly arises in lymph nodes, with fewer than 30% of cases originating in extranodal sites.

Case Presentation: We report the case of a 39-year-old previously healthy male patient who presented with paraneoplastic pemphigus in the setting of a large intraperitoneal mass with no associated lymphadenopathy. Read More

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http://dx.doi.org/10.1159/000489602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006627PMC
May 2018
15 Reads

Painful mouth ulcers.

Cutis 2018 May;101(5):327;341;342;345

Departments of Dermatology and Pathology, Cleveland Clinic Foundation, Ohio, USA.

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May 2018
1 Read

Buccal paraneoplastic pemphigus multi-resistant: Case report and review of diagnostic and therapeutic strategies.

J Stomatol Oral Maxillofac Surg 2018 Dec 8;119(6):506-509. Epub 2018 Jun 8.

Department of oral and maxillofacial surgery, cliniques universitaires Saint-Luc, université catholique de Louvain, avenue Hippocrate 10, 1200 Woluwe-Saint-Lambert, Belgium.

Paraneoplastic pemphigus is a rare autoimmune blistering disease generally associated with malignancy. The clinical presentation consists typically of painful and diffuse erosive stomatitis that may be accompanied by polymorphic skin lesions and systemic involvement. Diagnosis is based on clinical manifestations and confirmed by histology and immunological testing. Read More

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http://dx.doi.org/10.1016/j.jormas.2018.06.003DOI Listing
December 2018
44 Reads

Paraneoplastic pemphigus in Russian patients: a single center case series.

Int J Dermatol 2018 08 24;57(8):e44-e46. Epub 2018 May 24.

Division of Immune-mediated Skin Diseases, Department of Dermatology and Venereology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

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http://dx.doi.org/10.1111/ijd.14056DOI Listing
August 2018
13 Reads

Paraneoplastic pemphigus foliaceus related to underlying breast cancer.

Clin Exp Dermatol 2018 10 16;43(7):817-818. Epub 2018 May 16.

Department of Dermatology, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK.

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http://dx.doi.org/10.1111/ced.13602DOI Listing
October 2018

Lichenoid paraneoplastic pemphigus associated with follicular lymphoma without detectable autoantibodies.

Clin Exp Dermatol 2018 Jul 14;43(5):613-615. Epub 2018 May 14.

Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1111/ced.13563DOI Listing

Paraneoplastic pemphigus without antibodies to desmoglein 1 and 3.

Dermatol Online J 2018 02 15;24(2). Epub 2018 Feb 15.

Feinberg School of Medicine, Northwestern University, Chicago, Illinois,.

Paraneoplastic pemphigus is a severe autoimmune blistering disease presenting in the setting of underlying malignancy. Paraneoplastic pemphigus is associated with diffuse painful stomatitis throughout the oral cavity with extension to the lips. The cutaneous findings are varied and have been described as lichenoid, pemphigoid, and targetoid lesions. Read More

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February 2018
3 Reads

Paraneoplastic pemphigus with anti-desmocollin 3 autoantibodies and chronic lymphocytic leukemia.

Postepy Dermatol Alergol 2018 Feb 20;35(1):113-115. Epub 2018 Feb 20.

Department of Dermatology and Immunodermatology, Medical University of Warsaw, Warsaw, Poland.

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http://dx.doi.org/10.5114/ada.2018.73171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872252PMC
February 2018
1 Read

Blistering diseases in the mature patient.

Clin Dermatol 2018 Mar - Apr;36(2):231-238. Epub 2017 Oct 3.

Department of Dermatovenereology, University Hospital Center Zagreb and University of Zagreb School of Medicine, Zagreb, Croatia. Electronic address:

Autoimmune blistering diseases (AIBD) are a group of chronic diseases affecting the skin and mucous membranes, with different presentation, clinical course, histologic and immunopathologic findings, and different therapeutic approach. Blisters develop as a result of autoantibodies directed against distinct adhesion structures within desmosomes or within the basement membrane zone. The most common AIBD that develops in the elderly is bullous pemphigoid (previously also named "pemphigoid senilis"), but mature patients can also present with other AIBD as mucous membrane pemphigoid, epidermolysis bullosa acquisita, paraneoplastic pemphigus, pemphigus vulgaris, pemphigus foliaceus, linear IgA dermatosis, and dermatitis herpetiformis. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2017.10.014DOI Listing
September 2018
13 Reads

[Paraneoplastic pemphigus associated with chronic lymphocytic leukemia: a case report].

Zhonghua Xue Ye Xue Za Zhi 2018 Feb;39(2):104

Department of Hematology, Hangzhou First People's Hospital, Hangzhou 310006, China.

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2018.02.005DOI Listing
February 2018

Paraneoplastic Pemphigus Associated With Castleman Disease Detected by 18F-FDG PET/CT.

Clin Nucl Med 2018 Jun;43(6):464-465

A 36-year-old woman suffering from oral ulcerations, skin rash, and dyspnea was suspected of having paraneoplastic pemphigus. An F-FDG PET/CT was performed to detect the underlying neoplasms and revealed an F-FDG-avid mass in the lower right retroperitoneum. The mucocutaneous lesions and dyspnea were relieved after the tumor excision, and the pathology indicated Castleman disease. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002072DOI Listing
June 2018
5 Reads

Clinical, immunological profile and follow up of patients with pemphigus: A study from India.

Indian J Dermatol Venereol Leprol 2018 Jul-Aug;84(4):408-413

Department of Dermatology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

Background: Pemphigus has a protracted course and multiple factors influence its prognosis. The objective of this study was to describe the epidemiology and clinical profile of pemphigus patients and to study its influence on treatment end points.

Methods: : This was a retrospective chart review done in an Indian tertiary care hospital from December 1991 to December 2013. Read More

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http://www.ijdvl.com/preprintarticle.asp?id=227157
Publisher Site
http://dx.doi.org/10.4103/ijdvl.IJDVL_323_17DOI Listing
November 2018
26 Reads

Lip ulceration in an immunocompromised patient.

JAAD Case Rep 2018 Apr 22;4(3):214-216. Epub 2018 Feb 22.

Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1016/j.jdcr.2017.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842327PMC
April 2018
1 Read

Paraneoplastic Pemphigus Associated with B-cell Chronic Lymphocytic Leukemia Treated with Ibrutinib and Rituximab.

Intern Med 2018 Aug 9;57(16):2395-2398. Epub 2018 Mar 9.

Department of Hematology, National Cancer Center Hospital, Japan.

Paraneoplastic pemphigus (PNP) is a severe autoimmune blistering disease associated with an underlying malignancy, and its prognosis is poor. We herein report the first patient with B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL)-associated PNP successfully treated with the Bruton's tyrosine kinase inhibitor ibrutinib and rituximab. Although his PNP lesions did not improve with ibrutinib monotherapy, the combination of ibrutinib and rituximab was effective against B-CLL/SLL-associated PNP. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/57/16/
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http://dx.doi.org/10.2169/internalmedicine.0578-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148183PMC
August 2018
26 Reads

Oral pemphigus.

G Ital Dermatol Venereol 2018 Jun 6;153(3):383-388. Epub 2018 Mar 6.

Department of Surgery, Medicine, Dentistry, Transplantation Morphology, Oncology, and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

The involvement of the oral mucosa in patients affected by pemphigus vulgaris (PV), paraneoplastic, IgA pemphigus, and in some cases iatrogenic pemphigus is common and often a prelude to skin lesions. Intraepidermal bullae are caused by acantholysis, induced by IgG autoantibodies directed against the desmosomes and the domain of numerous keratinocytes self-antigens desmogleins (namely cadherins), thus supporting the autoimmune nature of the disease. Apoptosis may contribute to the acantholysis. Read More

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http://dx.doi.org/10.23736/S0392-0488.18.05887-XDOI Listing
June 2018
5 Reads

Pemphigus group: overview, epidemiology, mortality, and comorbidities.

Authors:
Khalaf Kridin

Immunol Res 2018 04;66(2):255-270

Department of Dermatology, Rambam Health Care Campus, POB 9602, 31096, Haifa, Israel.

Pemphigus forms a group of rare autoimmune bullous diseases that affect the skin and mucous membranes. This group has a chronic course leading to high morbidity and mortality. It is characterized by the production of pathogenic autoantibodies directed against different proteins of the desmosome, leading histologically to intraepidermal cleavage, and clinically to vesicles and erosions on the epithelium of the mucous membranes and/or the skin. Read More

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http://dx.doi.org/10.1007/s12026-018-8986-7DOI Listing
April 2018
4 Reads

Paraneoplastic autoimmune multi-organ syndrome is a distinct entity from traditional pemphigus subtypes.

Authors:
Kyle T Amber

Nat Rev Dis Primers 2018 Feb 22;4:18012. Epub 2018 Feb 22.

Department of Dermatology, University of California Irvine Health, Irvine, CA, USA.

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http://dx.doi.org/10.1038/nrdp.2018.12DOI Listing
February 2018
2 Reads

Authors' reply: Paraneoplastic autoimmune multi-organ syndrome is a distinct entity from traditional pemphigus subtypes.

Nat Rev Dis Primers 2018 Feb 22;4:18013. Epub 2018 Feb 22.

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1038/nrdp.2018.13DOI Listing
February 2018
8 Reads

Paraneoplastic Pemphigus in a 34-year-old.

Dermatol Online J 2017 Dec 15;23(12). Epub 2017 Dec 15.

New York University Health, New York.

Paraneoplastic Pemphigus (PNP) is a rare and often fatal autoimmune mucocutaneous blistering disease associated with an underlying malignancy. It is thought to be caused by antibodies to tumor antigenscross-reacting with epithelial antigens, specifically desmosomal and hemidesmosomal antigens. There are at least five clinical morphologic variants of PNP, with the earliest and most consistent finding beingsevere stomatitis. Read More

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December 2017
4 Reads

Rituximab and intravenous immunoglobulin as alternatives to long-term systemic corticosteroids in the treatment of pemphigus: a single center case series of 63 patients.

Dermatol Online J 2018 Jan 19;23(12). Epub 2018 Jan 19.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

Rituximab and intravenous immunoglobulin [IVIg] have recently emerged as effective treatments for pemphigus refractory to corticosteroids [CS]. This case series sought to compare the clinical, serologic,and adverse effects of CS, IVIg, and rituximab in patients with pemphigus. A retrospective review of 63 patients with pemphigus vulgaris (PV), pemphigus foliaceus (PF), or paraneoplastic pemphigus (PNP)was performed. Read More

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January 2018
4 Reads

Image Gallery: Paraneoplastic pemphigus and follicular dendritic cell sarcoma.

Authors:
M F Jonkman H H Pas

Br J Dermatol 2018 02;178(2):e146

Department of Dermatology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, the Netherlands.

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http://dx.doi.org/10.1111/bjd.16146DOI Listing
February 2018
2 Reads

Tocilizumab Cannot Prevent the Development of Bronchiolitis Obliterans in Patients With Castleman Disease-Associated Paraneoplastic Pemphigus.

Authors:
Liyang Gu Shuang Ye

J Clin Rheumatol 2018 Feb 1. Epub 2018 Feb 1.

Department of Rheumatology Ren Ji Hospital South Campus Shanghai Jiaotong University School of Medicine, Shanghai People's Republic of China

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http://dx.doi.org/10.1097/RHU.0000000000000675DOI Listing
February 2018
7 Reads

Paraneoplastic pemphigus mimicking toxic epidermal necrolysis: An underdiagnosed entity?

JAAD Case Rep 2018 Jan 19;4(1):67-71. Epub 2017 Dec 19.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

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http://dx.doi.org/10.1016/j.jdcr.2017.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771756PMC
January 2018
8 Reads

Diagnostic patterns and delays in autoimmune blistering diseases of the mouth: A cross-sectional study.

Oral Dis 2018 Jul 16;24(5):802-808. Epub 2018 Apr 16.

Department of Oral and Maxillofacial Surgery, Oral Medicine, and Periodontics, School of Dentistry, The University of Jordan, Amman, Jordan.

Objectives: To describe the natural history and factors influencing diagnostic delays among patients with autoimmune blistering diseases of the mouth.

Materials And Methods: In this cross-sectional study, 27 newly diagnosed patients were interviewed, and professional and patient delays were calculated. Disease extent and severity scores were determined using Saraswat scoring system. Read More

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http://dx.doi.org/10.1111/odi.12839DOI Listing
July 2018
3 Reads

[Paraneoplasms of the skin].

Internist (Berl) 2018 Feb;59(2):134-144

Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München, Ludwig-Maximilians-Universität München, München, Deutschland.

The cutaneous manifestations of malignancies include nonmalignant skin disorders that occur in association with malignancies (facultative paraneoplastic dermatoses) and skin disorders that are always associated with hematologic diseases or solid tumors (obligate paraneoplastic dermatoses). Paraneoplastic increase of growth factors or immunological reactions lead to a variety of inflammatory, hyperkeratotic or proliferative skin reactions. When paraneoplastic dermatoses develop before cancer is diagnosed, recognition of these skin diseases can accelerate both the diagnosis and treatment. Read More

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http://dx.doi.org/10.1007/s00108-017-0372-3DOI Listing
February 2018
5 Reads

A polymorphous bullous dermatosis.

Lancet Oncol 2017 12;18(12):e776

Department of Dermatology, Assistance Publique - Hôpitaux de Paris, Henri Mondor Hospital, Créteil, France.

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http://dx.doi.org/10.1016/S1470-2045(17)30461-8DOI Listing
December 2017
6 Reads

Paraneoplastic Pemphigus with Underlying Retroperitoneal Inflammatory Myofibroblastic Tumor: A Case Report and Review of the Literature.

Indian Dermatol Online J 2017 Nov-Dec;8(6):478-481

Department of Pharmacology, Islamic Azad University, Science and Research Branch, Tehran, Iran.

Inflammatory myofibroblastic tumor (IMT) is a peculiar low-grade neoplasm of spindle cell fibroblasts and myofibroblasts in an inflammatory background. The lung is the most common site of involvement. Here, we report a case of paraneoplastic pemphigus (PNP)-associated with an extensive retroperitoneal IMT. Read More

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http://www.idoj.in/text.asp?2017/8/6/478/218322
Publisher Site
http://dx.doi.org/10.4103/idoj.IDOJ_17_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707843PMC
December 2017
8 Reads

Paraneoplastic Pemphigus: Insight into the Autoimmune Pathogenesis, Clinical Features and Therapy.

Int J Mol Sci 2017 Nov 26;18(12). Epub 2017 Nov 26.

Dipartimento di Medicina Interna e Specialità Mediche, Dermatologia, Sapienza Università di Roma, Piazzale Aldo Moro, 5, 00185 Roma, Italy.

Paraneoplastic pemphigus is a rare autoimmune skin disease that is always associated with a neoplasm. Usually, oral, skin, and mucosal lesions are the earliest manifestations shown by paraneoplastic pemphigus patients. The pathogenesis of paraneoplastic pemphigus is not yet completely understood, although some immunological aspects have been recently clarified. Read More

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http://dx.doi.org/10.3390/ijms18122532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751135PMC
November 2017
15 Reads

Diagnosis of Castleman Disease.

Hematol Oncol Clin North Am 2018 02;32(1):53-64

Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, M230 Boston, MA 02215, USA; VA Boston Healthcare System, 1400 VFW Parkway, West Roxbury, MA, USA. Electronic address:

Castleman disease (CD) is a rare and heterogenous group of disorders sharing in common an abnormal lymph node pathology. CD comprises distinct subtypes with different prognoses. Unicentric CD and multicentric CD are featured by specific systemic manifestations and may be associated with Kaposi sarcoma, non-Hodgkin and Hodgkin lymphoma, and POEMS syndrome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08898588173014
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http://dx.doi.org/10.1016/j.hoc.2017.09.005DOI Listing
February 2018
40 Reads

Paraneoplastic pemphigus without detectable anti-plakin antibodies in a patient with non-Hodgkin lymphoma.

Ann Hematol 2018 Mar 16;97(3):543-544. Epub 2017 Nov 16.

Department of Dermatology, School of Medicine, University Clinic of Navarra, University of Navarra, PO Box 4209, Pamplona, Navarre, Spain.

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http://dx.doi.org/10.1007/s00277-017-3171-yDOI Listing
March 2018
4 Reads

SnapshotDx Quiz: November 2017.

J Invest Dermatol 2017 11;137(11):e193

Department of Dermatology and Cutaneous Surgery, University of Miami L. Miller School of Medicine. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.09.015DOI Listing
November 2017
3 Reads

Spectrum of orocutaneous disease associations: Immune-mediated conditions.

J Am Acad Dermatol 2017 Nov;77(5):795-806

Division of Dermatology, Baylor University Medical Center, Dallas, Texas. Electronic address:

There are a number of diseases that manifest both on the skin and the oral mucosa, and therefore the importance for dermatologists in clinical practice to be aware of these associations is paramount. In the following continuing medical education series, we outline orocutaneous disease associations with both immunologic and inflammatory etiologies. Read More

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http://dx.doi.org/10.1016/j.jaad.2017.02.019DOI Listing
November 2017
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Clinical Analysis of Unicentric Castleman's Disease with Paraneoplastic Pemphigus and Bronchiolitis Obliterans.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2017 Aug;39(4):492-498

Department of Hematology,PUMC Hospital, CAMS and PUMC,Beijing 100730,China.

Objective To investigate the clinical features of unicentric Castleman's disease(UCD)with paraneoplastic pemphigus(PNP)and bronchiolitis obliterans(BO).Method Data of UCD patients with PNP and BO from Peking Union Medical College Hospital were retrospectively analyzed,along with literatures review. Results Totally 23 cases(11 males and 12 females)were enrolled. Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.2017.04.006DOI Listing
August 2017
4 Reads