G Ital Dermatol Venereol 2018 Jun 6;153(3):383-388. Epub 2018 Mar 6.
Department of Surgery, Medicine, Dentistry, Transplantation Morphology, Oncology, and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
The involvement of the oral mucosa in patients affected by pemphigus vulgaris (PV), paraneoplastic, IgA pemphigus, and in some cases iatrogenic pemphigus is common and often a prelude to skin lesions. Intraepidermal bullae are caused by acantholysis, induced by IgG autoantibodies directed against the desmosomes and the domain of numerous keratinocytes self-antigens desmogleins (namely cadherins), thus supporting the autoimmune nature of the disease. Apoptosis may contribute to the acantholysis. Read More