330 results match your criteria Pemphigus IgA


Clinical and Immunological Study of 30 Cases With Both IgG and IgA Anti-Keratinocyte Cell Surface Autoantibodies Toward the Definition of Intercellular IgG/IgA Dermatosis.

Front Immunol 2018 7;9:994. Epub 2018 May 7.

Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan.

Several sporadic cases, in which direct and indirect immunofluorescence studies simultaneously detected IgG and IgA autoantibodies to keratinocyte cell surfaces, have been reported mainly under the name of IgG/IgA pemphigus. However, there have been no systematic studies for this condition. In this study, we collected 30 cases of this condition from our cohort of more than 5,000 autoimmune bullous disease cases, which were consulted for our diagnostic methods from other institutes, and summarized their clinical and immunological findings. Read More

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May 2018
1 Read

Italian guidelines in pemphigus. Adapted from the European Dermatology Forum (EDF) and European Academy of Dermatology And Venerology (EADV).

G Ital Dermatol Venereol 2018 May 31. Epub 2018 May 31.

Clinica Dermatologica, Università di Brescia, Brescia, Italy.

Pemphigus is a life threatening autoimmune epidermal blistering disease involving skin and mucous membranes. Pemphigus usually affects middle age men and women involving oral mucosa first and then spreading on the skin. It is caused by the presence of autoantibodies (IgG and less frequently by IgA) directed against desmogleins, and/or other glycoproteins that plays a critical role in cell-cell attachment. Read More

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Blistering diseases in the mature patient.

Clin Dermatol 2018 Mar - Apr;36(2):231-238. Epub 2017 Oct 3.

Department of Dermatovenereology, University Hospital Center Zagreb and University of Zagreb School of Medicine, Zagreb, Croatia. Electronic address:

Autoimmune blistering diseases (AIBD) are a group of chronic diseases affecting the skin and mucous membranes, with different presentation, clinical course, histologic and immunopathologic findings, and different therapeutic approach. Blisters develop as a result of autoantibodies directed against distinct adhesion structures within desmosomes or within the basement membrane zone. The most common AIBD that develops in the elderly is bullous pemphigoid (previously also named "pemphigoid senilis"), but mature patients can also present with other AIBD as mucous membrane pemphigoid, epidermolysis bullosa acquisita, paraneoplastic pemphigus, pemphigus vulgaris, pemphigus foliaceus, linear IgA dermatosis, and dermatitis herpetiformis. Read More

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October 2017
1 Read

Effectiveness and Safety of Rituximab in Recalcitrant Pemphigoid Diseases.

Front Immunol 2018 19;9:248. Epub 2018 Feb 19.

Center for Blistering Diseases, Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Introduction: Rituximab (RTX) is a monoclonal antibody targeting CD20, a transmembrane protein expressed on B cells, causing B cell depletion. RTX has shown great efficacy in studies of pemphigus vulgaris, but data of pemphigoid diseases are limited.

Objective: To assess the effectiveness and safety of RTX in pemphigoid diseases. Read More

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February 2018
1 Read

Oral pemphigus.

G Ital Dermatol Venereol 2018 Jun 6;153(3):383-388. Epub 2018 Mar 6.

Department of Surgery, Medicine, Dentistry, Transplantation Morphology, Oncology, and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

The involvement of the oral mucosa in patients affected by pemphigus vulgaris (PV), paraneoplastic, IgA pemphigus, and in some cases iatrogenic pemphigus is common and often a prelude to skin lesions. Intraepidermal bullae are caused by acantholysis, induced by IgG autoantibodies directed against the desmosomes and the domain of numerous keratinocytes self-antigens desmogleins (namely cadherins), thus supporting the autoimmune nature of the disease. Apoptosis may contribute to the acantholysis. Read More

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June 2018
3 Reads

Pemphigus group: overview, epidemiology, mortality, and comorbidities.

Authors:
Khalaf Kridin

Immunol Res 2018 Apr;66(2):255-270

Department of Dermatology, Rambam Health Care Campus, POB 9602, 31096, Haifa, Israel.

Pemphigus forms a group of rare autoimmune bullous diseases that affect the skin and mucous membranes. This group has a chronic course leading to high morbidity and mortality. It is characterized by the production of pathogenic autoantibodies directed against different proteins of the desmosome, leading histologically to intraepidermal cleavage, and clinically to vesicles and erosions on the epithelium of the mucous membranes and/or the skin. Read More

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April 2018
1 Read

[Humoral immune diseases: Cutaneous vasculitis and auto-immune bullous dermatoses].

Authors:
Janine Wechsler

Ann Pathol 2018 Feb 27;38(1):31-42. Epub 2017 Dec 27.

Département de pathologie, service d'anatomie et de cytologie pathologiques, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address:

Humoral immunity is the cause of multiple diseases related to antibodies (IgA, IgG, IgM) produced by the patient. Two groups of diseases are identified. The first group is related to circulating antigen-antibody complexes. Read More

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February 2018
4 Reads

The importance of direct immunofluorescence in pemphigus herpetiformis diagnosis.

An Bras Dermatol 2017 ;92(5 Suppl 1):145-147

Dermatology Outpatient Clinic at Hospital do Açúcar de Alagoas do Centro Universitário Tiradentes, Maceió, Alagoas (AL), Brazil.

Pemphigus herpetiformis is an autoimmune bullous disease, that combines clinical features of dermatitis herpetiformis and linear IgA bullous dermatosis and immunological characteristics of pemphigus, which makes this disease peculiar and this diagnosis rarely suspected in the first evaluation of the patient. The reported case is of a patient with clinically bullous disease similar to dermatitis herpetiformis, whose multiple biopsies were inconclusive, and only after direct immunofluorescence with a pemphigus pattern (intraepidermal intercellular pattern) the confirmation of the diagnosis was possible. Read More

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March 2018
4 Reads

Spectrum of Autoimmune Bullous Diseases in Northern Greece. A 4-year Retrospective Study and Review of the Literature.

Acta Dermatovenerol Croat 2017 Oct;25(3):195-201

Foteini Lamprou, MD, MSc, PhD candidate, 2nd University Department of Dermatology Papageorgiou General Hospital Aristotle University of Thessaloniki, Ring Road, Municipality of Pavlos Melas, Area of N. Efkarpia, 56403 Thessaloniki, Greece;

Bullous Diseases Unit at the 2nd Department of Dermatology and Venereology, Aristotle University of Thessaloniki was founded with the aim to provide the optimal diagnostic approach and treatment of patients with autoimmune bullous diseases (AΙBD). We processed all AIBD files of patients diagnosed from 2011 to 2014 in order to record all epidemiological data and therapeutic manipulations during monitoring. 57 patients were diagnosed with intraepidermal and 62 with subepidermal bullous diseases. Read More

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October 2017
9 Reads

Anti-Desmoglein 1 IgG/IgA-Pemphigus in Verbindung mit einem Thymom.

J Dtsch Dermatol Ges 2017 Nov;15(11):1147-1149

Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie. Universitätsklinikum Würzburg, Würzburg, Deutschland.

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November 2017
1 Read

Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizing with MYZAP, p0071, desmoplakins 1 and 2 and ARVCF.

Clin Exp Dermatol 2017 Dec 15;42(8):874-880. Epub 2017 Oct 15.

Georgia Dermatopathology Associates, Atlanta, GA, USA.

Background: We identified a new variant of endemic pemphigus foliaceus in El Bagre, Colombia, South America, which we term El Bagre-EPF, and observed reactivity to arrector pili muscle (APM), thus we tested for autoimmunity to APM.

Methods: We took skin biopsies from 30 patients with El Bagre-EPF and 30 healthy controls (HCs) matched by age, sex and occupation, who were all from the endemic area, and tested these using direct immunofluorescence (DIF), confocal microscopy, immunohistochemistry and immunoblotting (IB).

Results: Of the 30 patients with El Bagre-EPF, 27 had autoantibodies to APM that colocalized with commercial antibodies to myocardium-enriched zonula occludens-1-associated protein (MYZAP), desmoplakin (DP)1 and DP2, plakophilin 4, and Armadillo repeat gene deleted in velo-cardio-facial syndrome (ARVCF) (P < 0. Read More

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December 2017
3 Reads
1.23 Impact Factor

Anti-desmoglein 1 IgG/IgA pemphigus associated with thymoma.

J Dtsch Dermatol Ges 2017 Nov 14;15(11):1147-1148. Epub 2017 Oct 14.

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

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November 2017
4 Reads

A comparative study of expression of Fc receptors in relation to the autoantibody-mediated immune response and neutrophil elastase expression in autoimmune blistering dermatoses.

Pol J Pathol 2017;68(2):109-116

Here we investigated the cutaneous CD32A and CD89 expression in relation to the neutrophil elastase (NE) expression and serum level of anti-desmoglein 1 and 3 (DSG1/DSG3) IgG in pemphigus, anti-BP180/BP230 IgG in bullous pemphigoid (BP), anti-gliadin nonapeptides (npG), tissue (tTG), and epidermal transglutaminases (eTG) IgA in dermatitis herpetiformis (DH). The examined material consisted of skin/mucosal tissues and sera. In total, 87 patients were studied. Read More

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December 2017
6 Reads

IgA multiple myeloma in a patient with an IgG pemphigus foliaceus-like exanthem.

Int J Dermatol 2017 Oct 30;56(10):1058-1060. Epub 2017 Aug 30.

Department of Dermatology, Harvard Medical School, Boston, MA, USA.

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October 2017
1 Read

The Value of Direct Immunofluorescence on Proteinase-Digested Formalin-Fixed Paraffin-Embedded Skin Biopsies.

Am J Dermatopathol 2018 Feb;40(2):111-117

Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA.

Direct immunofluorescence (DIF) on frozen tissue (DIF-F) is the method of choice for the identification of immune deposits present in skin and other tissues. DIF can also be performed on formalin-fixed paraffin-embedded tissue (DIF-P) after antigen retrieval with proteases and has proven to be of value in renal pathology. However, its utility in skin biopsies has not been fully examined. Read More

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February 2018
5 Reads

Routine detection of serum antidesmocollin autoantibodies is only useful in patients with atypical pemphigus.

Exp Dermatol 2017 12 29;26(12):1267-1270. Epub 2017 Oct 29.

Lübeck Institute of Experimental Dermatology (LIED), Lübeck, Germany.

Autoantibodies against the 3 desmocollin (Dsc; Dsc1-Dsc3) isoforms have been described in different pemphigus variants. Here, we developed state-of-the-art detection systems for serum anti-Dsc1, Dsc2 and Dsc1 IgG and IgA. These assays were applied in 5 different cohorts including pemphigus vulgaris (PV) patients with compatible direct immunofluorescence (IF) microscopy but no reactivity against desmogleins 1 and 3 (n = 24) and sera from patients with autoimmune blistering diseases with positive direct IF microscopy taken at the time of diagnosis (n = 749). Read More

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December 2017
3 Reads

Evaluation of Autoimmune Bullous Diseases in Elderly Patients in Iran: A 10-Year Retrospective Study.

Skinmed 2017 1;15(3):175-180. Epub 2017 Jun 1.

Department of Dermatology, Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Autoimmune bullous diseases (ABDs) are uncommon but significant skin disorders with relatively high morbidity and mortality. Some surveys have been carried out to describe the spectrum of ABDs in a region, but this is the first that has focused on ABDs in elderly patients. This study was conducted to determine the clinicoepidemiologic features of ABDs in elderly patients. Read More

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June 2017
2 Reads

Possible role of Helicobacter pylori in diseases of dermatological interest.

J Biol Regul Homeost Agents 2017 APR-JUN;31(2 Suppl. 2):57-77

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

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July 2017
13 Reads

Selective Plasma Exchange for the Removal of Pemphigus Autoantibodies, Fibrinogen, and Factor XIII in Pemphigus Vulgaris.

Ther Apher Dial 2017 Jun;21(3):226-231

Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.

Pemphigus vulgaris is a serious autoimmune skin disorder associated with desmoglein 1 and 3. Selective plasma exchange (SePE) for pemphigus vulgaris remains unknown. We investigated the removal characteristics of pemphigus autoantibodies, immunoglobulins, and fibrinogen in three cases. Read More

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June 2017
4 Reads

Intraepidermal neutrophilic dermatosis type of IgA pemphigus with circulating linear IgA disease antibodies associated with ulcerative colitis.

J Eur Acad Dermatol Venereol 2018 Jan 16;32(1):e10-e11. Epub 2017 Jul 16.

Department of Dermatology and Allergy, Faculty of Medicine and Health Sciences, University of Oldenburg, Klinikum Oldenburg AöR, Oldenburg, Germany.

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January 2018
3 Reads

Case of shift from linear immunoglobulin A bullous dermatosis to pemphigus herpetiformis for a short period of time.

J Dermatol 2017 Feb 5;44(2):189-193. Epub 2016 Nov 5.

Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.

Pemphigus herpetiformis (PH) is a rare variant of pemphigus characterized by erythemas and vesicles, tending to present with annular-shaped lesions. Immunologically, immunoglobulin (Ig)G deposition at the keratinocyte cell surfaces is observed. Linear IgA bullous dermatosis (LABD) is a rare subepidermal blistering disease with linear IgA deposits at the epidermal basement membrane zone (BMZ). Read More

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February 2017
9 Reads

IgA pemphigus: lumping or splitting?

Authors:
S Geller E Sprecher

Br J Dermatol 2017 08 8;177(2):581-582. Epub 2017 Jun 8.

Department of Dermatology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel.

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August 2017
2 Reads

Utility of immunofluorescence in dermatology.

Indian Dermatol Online J 2017 Jan-Feb;8(1):1-8

Department of Dermatology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.

Immunofluorescence (IF) tests have redefined our understanding of many immune-mediated skin diseases, especially autoimmune blistering diseases (AIBDs). Nomenclature of certain AIBDs (for example, linear IgA diseases and IgA pemphigus) has been done based solely on the finding of tissue-bound immunoreactants as detected by IF tests. Direct and indirect are the two major types of IF tests; they are not only useful in the diagnosis but also guide the clinician in the treatment at least in certain AIBDs, as the titer of circulating antibodies as detected by IF reflects the disease activity. Read More

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February 2017
1 Read

Bullous, pseudobullous, & pustular dermatoses.

Authors:
Mark R Wick

Semin Diagn Pathol 2017 May 14;34(3):250-260. Epub 2016 Dec 14.

Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Charlottesville, VA, United States. Electronic address:

Several dermatoses are typified by the formation of spaces (blisters; bullae) within or beneath the epidermis. These may be acellular or filled with particular species of inflammatory cells. Etiological categories include infectious, immune-mediated, genetic, drug-related, and idiopathic lesions. Read More

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May 2017
5 Reads

Prospective studies on the routine use of a novel multivariant enzyme-linked immunosorbent assay for the diagnosis of autoimmune bullous diseases.

J Am Acad Dermatol 2017 May 28;76(5):889-894.e5. Epub 2016 Dec 28.

Department of Dermatology, University of Lübeck, Lübeck, Germany; Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany. Electronic address:

Background: Serologic diagnosis of autoimmune blistering disease (AIBD) usually follows a sophisticated multistep algorithm.

Objective: We sought validation of a multivariant enzyme-linked immunosorbent assay (ELISA) in the routine diagnosis of AIBD.

Methods: The multivariant ELISA comprising 6 recombinant immunodominant forms of major AIBD target antigens, ie, desmoglein 1, desmoglein 3, envoplakin, BP180, BP230, and type VII collagen was applied in: (1) a cohort of well-characterized AIBD (n = 173) and control sera (n = 130), (2) a prospective multicenter study with 204 sera from patients with newly diagnosed AIBD with positive direct immunofluorescence microscopy, and (3) a prospective monocenter study with 292 consecutive sera from patients with clinical suspicion of AIBD in comparison with the conventional multistep diagnostic algorithm. Read More

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May 2017
9 Reads

Discrepancies among clinical, histological and immunological findings in IgA pemphigus: a case report and literature survey.

Postepy Dermatol Alergol 2016 Dec 2;33(6):480-484. Epub 2016 Dec 2.

Chair of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Nicolaus Copernicus University in Torun, Faculty of Medicine, Bydgoszcz, Poland.

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December 2016
9 Reads

Non-paraneoplastic autoimmune subepidermal bullous disease associated with fatal bronchiolitis obliterans.

J Dermatol 2017 Apr 3;44(4):461-464. Epub 2016 Dec 3.

Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Bronchiolitis obliterans is a small-airway obstructive lung disease for which immunologically mediated pathogenesis is supposed. Frequent association of bronchiolitis obliterans with paraneoplastic pemphigus is well known, but its association with other autoimmune bullous diseases has not been reported except for a case of anti-laminin-332-type mucous membrane pemphigoid in a patient with chronic graft-versus-host disease. We report a case of non-paraneoplastic autoimmune subepidermal bullous disease associated with fatal bronchiolitis obliterans in a patient without transplantation. Read More

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April 2017
5 Reads

Crusted impetigo-like lesion on the face: a case of IgG/IgA pemphigus.

J Eur Acad Dermatol Venereol 2017 Jun 12;31(6):e289-e290. Epub 2016 Dec 12.

Department of Dermatology, Sapporo City General Hospital, North 11, West 13, Chuo-ku, Sapporo, 060-8604, Japan.

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June 2017
2 Reads

Paraneoplastic Pemphigus and Autoimmune Blistering Diseases Associated with Neoplasm: Characteristics, Diagnosis, Associated Neoplasms, Proposed Pathogenesis, Treatment.

Am J Clin Dermatol 2017 Feb;18(1):105-126

Department of Dermatology, University of Illinois College of Medicine, UIC-Derm, MC624, 808 S. Wood Street, R380, Chicago, IL, 60612, USA.

Autoimmune paraneoplastic and neoplasm-associated skin syndromes are characterized by autoimmune-mediated cutaneous lesions in the presence of a neoplasm. The identification of these syndromes provides information about the underlying tumor, systemic symptoms, and debilitating complications. The recognition of these syndromes is particularly helpful in cases of skin lesions presenting as the first sign of the malignancy, and the underlying malignancy can be treated in a timely manner. Read More

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February 2017
9 Reads

IgA pemphigus showing IgA antibodies to desmoglein 1 and 3.

Dermatol Pract Concept 2016 Oct 31;6(4):31-33. Epub 2016 Oct 31.

Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia.

Background: IgA pemphigus is a rare autoimmune vesiculo-pustular skin disease. Only approximately 70 cases have been reported to date. We report a case of IgA pemphigus with IgA antibodies to desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3). Read More

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October 2016
1 Read

Generalized pustular psoriasis induced by systemic steroid dose reduction.

An Bras Dermatol 2016 Sep-Oct;91(5):664-666

Fundação Alfredo da Matta (Fuam) - Manaus (AM), Brazil.

Generalized pustular psoriasis, or psoriasis of von Zumbusch, is an acute and severe clinical form of psoriasis, which usually occurs in patients with psoriasis undergoing aggravating factors. In this work, we report the case of a female patient, 70 years old, who developed generalized pustular psoriasis symptoms while reducing the dose of oral corticosteroids, improperly introduced for the treatment of alleged acute generalized exanthematous pustulosis. The differential diagnosis of generalized pustular psoriasis should be made with other pustular dermatoses, such as subcorneal pustulosis, IgA pemphigus and especially with acute generalized exanthematous pustulosis. Read More

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May 2017
2 Reads

Incidence of autoimmune bullous diseases in Serbia: a 20-year retrospective study.

J Dtsch Dermatol Ges 2016 Oct;14(10):995-1005

Institute of Social Medicine, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Background And Objectives: While most previous surveys on the clinico-epidemiological features of autoimmune bullous diseases (AIBDs) have predominantly focused on a single disease entity or just one disease group, there have been only few studies examining the incidence of various AIBDs. In the present study, we set out to determine the spectrum of AIBDs, to estimate the incidence of the most common AIBDs, and to examine their temporal trends in Central Serbia over a period of 20 years.

Methods: We retrospectively recruited 1,161 new AIBD cases diagnosed in Central Serbia during the period from January 1991 to December 2010. Read More

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October 2016
4 Reads
1.82 Impact Factor

Inzidenz von bullösen Autoimmunerkrankungen in Serbien: eine retrospektive Studie über 20 Jahre.

J Dtsch Dermatol Ges 2016 Oct;14(10):995-1006

Institut für Sozialmedizin, Medizinische Fakultät, Universität Belgrad, Belgrad, Serbien.

Hintergrund Und Ziele: Die meisten früheren Arbeiten zu den klinisch-epidemiologischen Merkmalen von bullösen Autoimmunerkrankungen (AIBD) konzentrierten sich vor allem auf eine einzige Krankheitsentität oder nur eine Krankheitsgruppe; nur in wenigen Studien wurde die Inzidenz verschiedener AIBD untersucht. Bei der vorliegenden Studie war es unser Ziel, das gesamte Spektrum der AIBD zu betrachten, die Inzidenz der häufigsten AIBD zu ermitteln und die zeitlichen Trends ihres Auftretens in Zentralserbien über einen Zeitraum von 20 Jahren zu untersuchen.

Methoden: Wir rekrutierten retrospektiv 1161 AIBD-Fälle, die in Zentralserbien von Januar 1991 bis Dezember 2010 neu diagnostiziert wurden. Read More

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October 2016
6 Reads
1.82 Impact Factor

Complete remission of skin lesions in a patient with subcorneal pustular dermatosis (Sneddon-Wilkinson disease) treated with antimyeloma therapy: association with disappearance of M-protein.

Br J Dermatol 2017 May 27;176(5):1341-1344. Epub 2017 Jan 27.

Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.

Subcorneal pustular dermatosis (SPD), or Sneddon-Wilkinson disease, is a rare pustular skin disease that follows a chronic relapsing course. A well-known association exists between SPD and IgA monoclonal gammopathy of undetermined significance (MGUS), which exists in up to 40% of cases. SPD has also been observed in patients with IgA myeloma. Read More

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May 2017
1 Read

Bullous Pemphigoid with Lymphocytic Colitis: A Case Report and Short Literature Review.

Dermatol Ther (Heidelb) 2016 Sep 28;6(3):437-41. Epub 2016 Jul 28.

Department of Dermatology, Paracelsus Medical University, Salzburg, Austria.

The association of autoimmune bullous diseases (i.e., bullous pemphigoid, linear IgA disease, mucous membrane pemphigoid and IgA pemphigus) and inflammatory bowel disease, namely ulcerative colitis and Crohn's disease has formerly been reported. Read More

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September 2016
2 Reads

Prevalence and Age Distribution of Pemphigus and Pemphigoid Diseases in Germany.

J Invest Dermatol 2016 12 25;136(12):2495-2498. Epub 2016 Jul 25.

Department of Dermatology, University of Lübeck, Lübeck, Germany; Lübeck Institute of Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany. Electronic address:

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December 2016
3 Reads

Decreased fibrinolytic potential and morphological changes of fibrin structure in dermatitis herpetiformis.

J Dermatol Sci 2016 Oct 6;84(1):17-23. Epub 2016 Jul 6.

Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary. Electronic address:

Background: Recently, high prevalence of cryofibrinogenaemia has been observed in plasma of untreated dermatitis herpetiformis (DH) patients, and the pathological IgA and TG3 deposits in the papillary dermis were found to co-localize with fibrin and fibrinogen.

Objective: To study the fibrinolytic potential in plasma of untreated, dapsone and or/gluten-free diet treated DH patients as well as the in vitro effect of dapsone on the fibrinolytic profile.

Method: Plasma samples of 23 DH patients, 19 healthy subjects and 5 pemphigus vulgaris patients were investigated by a turbidimetric-clot lysis assay. Read More

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October 2016
3 Reads

Blistering diseases in neonates.

Curr Opin Pediatr 2016 Aug;28(4):500-6

aDermatology, St George HospitalbMedicine, University of New South Wales, Sydney, Australia.

Purpose Of Review: Neonatal blistering diseases are rare yet potentially fatal. Therefore, it is crucial for clinicians to know its broad range of differential diagnoses. This review discusses the recent literature on the causes and the most appropriate clinical approach to neonatal blistering diseases. Read More

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August 2016
10 Reads

Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress.

Am J Clin Dermatol 2016 Dec;17(6):653-671

Department of Dermatology, Veterans Affairs Medical Center Brooklyn and SUNY Downstate, 800 Poly Place, Brooklyn, NY, 11209, USA.

Subcorneal pustular dermatosis (SPD), also known as Sneddon-Wilkinson disease, is a rare, benign yet relapsing pustular dermatosis. Its incidence and prevalence have not been well studied. It characteristically presents as hypopyon pustules on the trunk and intertriginous areas of the body. Read More

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December 2016
1 Read

A Clinicopathological Study of Pemphigus in Eastern India with Special Reference to Direct Immunofluorescence.

Indian J Dermatol 2016 May-Jun;61(3):288-94

Department of Dermatology, Medical College and Hospital, Kolkata, West Bengal, India.

Background: Pemphigus is a group of chronic autoimmune vesico-bullous disorders in which the epidermis and the basement membrane zone are the focus of attack resulting in cutaneous and mucosal blister formation. Direct immunofluorescence (DIF) test is a very sensitive test for the diagnosis.

Aim: To study the clinico histopathological patterns of pemphigus in eastern India. Read More

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June 2016
1 Read

Juvenile IgA pemphigus: A case report and review of literature.

Indian J Dermatol Venereol Leprol 2016 Jul-Aug;82(4):439-42

Department of Dermatology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.

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April 2017
1 Read

Clinical and immunological studies of 49 cases of various types of intercellular IgA dermatosis and 13 cases of classical subcorneal pustular dermatosis examined at Kurume University.

Br J Dermatol 2017 Jan 17;176(1):168-175. Epub 2016 Oct 17.

Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.

Background: Intercellular IgA dermatosis (IAD) is a subset of autoimmune bullous disease exclusively with IgA antikeratinocyte cell-surface antibodies. The classification and pathogenesis of this condition are still obscure.

Objectives: To classify IAD and study its pathogenesis. Read More

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January 2017
2 Reads

Establishment of IgA ELISAs of mammalian recombinant proteins of human desmocollins 1-3.

J Dermatol Sci 2016 Jul 7;83(1):75-7. Epub 2016 Apr 7.

Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Fukuoka, Japan. Electronic address:

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July 2016
1 Read

Utility of Direct Immunofluorescence Studies in Subclassification of Autoimmune Sub-Epidermal Bullous Diseases: A 2-Year Study in a Tertiary Care Hospital.

Turk Patoloji Derg 2016 ;32(2):91-8

Department of Pathology Bharati Vidyapeeth Deemed University Medical College and Hospital, SANGLI, INDIA.

Objective: Sub-epidermal bullous disorders belong to immunobullous diseases which develop as a result of autoantibody action against epidermal basement membrane proteins. Clinically, they are tense bullae and do not rupture easily. They are classified into various forms based on histopathology and direct immunofluorescence patterns. Read More

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April 2017
4 Reads

Prolonged pustular eruption from hydroxychloroquine: an unusual case of acute generalized exanthematous pustulosis.

Cutis 2016 Mar;97(3):212-6

University of North Carolina, Chapel Hill, USA.

Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous eruption that often is a reaction to medications, most commonly antibiotics. Clinically, AGEP closely mimics pustular psoriasis and also is similar to subcorneal pustular dermatosis and IgA pemphigus. For clinicians, it is important to differentiate AGEP from pustular psoriasis. Read More

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March 2016
11 Reads

Pemphigus vulgaris-associated interstitial lung disease.

Dermatol Ther 2016 Jul 11;29(4):228-32. Epub 2016 Mar 11.

Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China.

Autoimmune bullous diseases (AIBDs)-associated interstitial lung disease (ILD) is extremely rare. Pemphigus vulgaris (PV) is an intraepidermal autoimmune blistering disease caused by circulating autoantibodies against desmoglein. To date, PV-associated ILD has rarely been reported in English literature. Read More

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July 2016
6 Reads

Case of paraneoplastic pemphigus with immunoglobulin (Ig)G and IgA antibodies to various antigens.

J Dermatol 2016 Aug 11;43(8):944-6. Epub 2016 Mar 11.

Department of Dermatology, Nippon Medical School, Tokyo, Japan.

A 63-year-old Japanese man with non-Hodgkin B-cell lymphoma presented with erythematous skin lesions on his entire body, with oral, ocular and anal mucosal lesions. The patient was diagnosed with paraneoplastic pemphigus. Immunofluorescence showed both immunoglobulin (Ig)G and IgA antibodies to keratinocyte cell surfaces. Read More

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August 2016
1 Read

Serum and salivary IgG and IgA antibodies to desmoglein 3 in mucosal pemphigus vulgaris.

Br J Dermatol 2016 Jul 27;175(1):113-21. Epub 2016 Apr 27.

Mucosal and Salivary Biology Division, Dental Institute, King's College London, London, U.K.

Background: The use of saliva for the diagnosis of pemphigus vulgaris (PV) by enzyme-linked immunosorbent assay (ELISA) using desmoglein (Dsg)3 antigen has not been extensively documented, nor has the detection of serum IgA antibodies to Dsg3.

Objectives: (i) To establish whether whole saliva might provide a suitable alternative to serum for diagnosing and monitoring PV; (ii) to investigate whether anti-Dsg3 IgA antibodies can be detected in serum and saliva and (iii) to establish whether there is an association between serum or saliva anti-Dsg3 antibodies and disease severity.

Methods: Precoated Dsg3 ELISA plates were used to test serum and/or saliva for IgG and IgA antibodies. Read More

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July 2016
1 Read

Childhood Pemphigus Foliaceus with Exclusive Immunoglobulin G Autoantibodies to Desmocollins.

Pediatr Dermatol 2016 Jan-Feb;33(1):e10-3

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Pemphigus refers to a group of potentially fatal blistering skin diseases that are often due to the deleterious effects of autoantibodies directed against desmosomal antigens. Although desmogleins have been mainly implicated as autoantigens in pemphigus, a steadily growing body of evidence suggests that other desmosomal proteins may be causally involved as well. Antibodies directed against desmocollin-3 have been shown to play a direct role in the pathogenesis of several types of pemphigus. Read More

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October 2016
4 Reads