709 results match your criteria Pemphigus Herpetiformis


Mechanisms of skin autoimmunity: Cellular and soluble immune components of the skin.

J Allergy Clin Immunol 2020 Jul;146(1):8-16

Division of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Unit of Dermatology, Karolinska University Hospital, Department of Dermatology and Venereology, Stockholm, Sweden; Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany. Electronic address:

Autoimmune diseases are driven by either T cells or antibodies reacting specifically to 1 or more self-antigens. Although a number of self-antigens associated with skin diseases have been identified, the causative antigen(s) remains unknown in the great majority of skin diseases suspected to be autoimmune driven. Model diseases such as pemphigus, dermatitis herpetiformis, and more recently psoriasis have added greatly to our understanding of skin autoimmunity. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.05.009DOI Listing

[Modern diagnostics of autoimmune bullous diseases].

Pathologe 2020 Jul;41(4):317-325

Klinik für Dermatologie, Allergologie und Venerologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Blisters and erosions of skin and mucous membranes are key features of the clinically heterogeneous group of autoimmune bullous diseases (AIBDs). These can be divided into pemphigoid diseases with autoantibodies against structural proteins of the dermal-epidermal junction, pemphigus diseases with autoantibodies against desmosomal proteins, and dermatitis herpetiformis with autoantibodies against transglutaminases 1 and 2. A differentiation based only on clinical features is often not sufficient. Read More

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http://dx.doi.org/10.1007/s00292-020-00795-8DOI Listing

Increased expression of in situ IL-31RA and circulating CXCL8 and CCL2 in pemphigus herpetiformis suggests participation of the IL-31 family in the pathogenesis of the disease.

J Eur Acad Dermatol Venereol 2020 Jun 12. Epub 2020 Jun 12.

Department of Dermatology, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil.

Background: Pemphigus herpetiformis (PH) is a rare clinical subtype of pemphigus with the presence of urticarial plaques, severe pruritus, rare acantholysis and eosinophilic spongiosis.

Objectives: The aim of this study was to investigate the influence of IL-31 and pro-inflammatory cytokines/chemokines in the pathogenesis of PH.

Methods: Twenty-five patients with PH and three groups: pemphigus foliaceus (PF = 14), pemphigus vulgaris (PV = 15) and healthy controls (HC = 20) were selected for this study. Read More

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http://dx.doi.org/10.1111/jdv.16730DOI Listing

Eosinophilic Dermatoses: Recognition and Management.

Am J Clin Dermatol 2020 May 11. Epub 2020 May 11.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Eosinophilic dermatoses encompass a broad spectrum of diseases of different etiologies hallmarked by eosinophilic infiltration of the skin and/or mucous membranes, with or without associated blood eosinophilia. The wide range of dermatological manifestations of this spectrum, including nodules and plaques, pustules, blisters, ulcers, and urticarial lesions, is reflected in a non-univocal classification system. We identified six groups of eosinophilic dermatoses based on the predominant anatomic level of involvement: (1) epidermal; (2) of the dermal-epidermal junction; (3) dermal; (4) of the hypodermis and muscle fascia; (5) of the pilosebaceous unit; and (6) vascular/perivascular. Read More

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http://dx.doi.org/10.1007/s40257-020-00520-4DOI Listing

Pemphigus Herpetiformis Masquerading as Tinea Corporis.

Indian Dermatol Online J 2019 Nov-Dec;10(6):727-729. Epub 2019 Nov 1.

Department of Pathology, Lady Hardinge Medical College and Associated Hospital, New Delhi, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_43_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859772PMC
November 2019

Alopecia in Autoimmune Blistering Diseases: A Systematic Review of Pathogenesis and Clinical Features of Disease.

Skin Appendage Disord 2019 Aug 10;5(5):263-275. Epub 2019 Jul 10.

Department of Dermatology, St. George Hospital, Sydney, New South Wales, Australia.

Background: Autoimmune blistering diseases (AIBD) are characterised by the body's production of autoantibodies against structural proteins in the epidermis and/or the basement membrane on cutaneous and mucosal surfaces. Alopecia is a complication of AIBD that has generally been overlooked in patients with severe blistering diseases because it is regarded as a cosmetic issue. Yet recent research into quality of life tools has found that stigmatisation by appearance plays a significant role in blistering diseases. Read More

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http://dx.doi.org/10.1159/000496836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751435PMC
August 2019
7 Reads

The clinical, immunological and pathological features for relapse of pemphigus herpetiformis: a univariate analysis of 26 cases.

Br J Dermatol 2020 Mar 8;182(3):802-804. Epub 2019 Nov 8.

Department of Dermatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China.

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http://dx.doi.org/10.1111/bjd.18518DOI Listing
March 2020
2 Reads

Bullous Diseases in Children: A Review of Clinical Features and Treatment Options.

Paediatr Drugs 2019 Oct;21(5):345-356

Department of Dermatology, University of Minnesota, 240 Phillips-Wangensteen Building, 516 Delaware Street Southeast, Minneapolis, MN, 55455, USA.

Bullous diseases are uncommon in children; however, as they have the potential to affect quality of life, occasionally have long-term side effects in the setting of scarring processes, and carry a rare risk of underlying malignancy [e.g., with paraneoplastic pemphigus (PNP)], knowledge of their clinical presentation and treatment options is essential. Read More

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http://dx.doi.org/10.1007/s40272-019-00349-3DOI Listing
October 2019
5 Reads

Complement Activation in Autoimmune Bullous Dermatoses: A Comprehensive Review.

Front Immunol 2019 26;10:1477. Epub 2019 Jun 26.

Department of Pathology, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands.

Autoimmune bullous dermatoses (AIBD) are characterized by circulating autoantibodies that are either directed against epidermal antigens or deposited as immune complexes in the basement membrane zone (BMZ). The complement system (CS) can be activated by autoantibodies, thereby triggering activation of specific complement pathways. Local complement activation induces a pathogenic inflammatory response that eventually results in the formation of a sub- or intraepidermal blister. Read More

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http://dx.doi.org/10.3389/fimmu.2019.01477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606728PMC
June 2019
3 Reads

Diagnostic criteria for pemphigus herpetiformis.

Int J Dermatol 2019 11 8;58(11):e216-e217. Epub 2019 Jul 8.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1111/ijd.14584DOI Listing
November 2019
4 Reads

Development of a Desmocollin-3 Active Mouse Model Recapitulating Human Atypical Pemphigus.

Front Immunol 2019 19;10:1387. Epub 2019 Jun 19.

Laboratory of Cutaneous Biology, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Pemphigus vulgaris (PV) is a life-threatening mucocutaneous autoimmune blistering disease. It is often associated with autoantibodies to the desmosomal adhesion proteins Desmoglein 3 (DSG3) and Desmoglein 1 (DSG1). Recently, auto-antigens, such as desmocollins and others have been described in PV and in atypical pemphigus forms such as Pemphigus Herpetiformis (PH), Pemphigus Vegetans (PVeg), and Paraneoplastic Pemphigus (PP). Read More

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http://dx.doi.org/10.3389/fimmu.2019.01387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593104PMC
June 2019
4 Reads

Review of autoimmune blistering diseases: the Pemphigoid diseases.

J Eur Acad Dermatol Venereol 2019 Sep 11;33(9):1685-1694. Epub 2019 Jul 11.

St George Hospital, Sydney, Australia.

Autoimmune Blistering Diseases of the Pemphigoid type is characterised by sub-epidermal blisters (SEB) with circulating autoantibodies against components of the basement membrane zone (BMZ). The main disorders to date include bullous pemphigoid (BP), pemphigoid gestationis, mucous membrane pemphigoid (MMP), epidermolysis bullosa acquisita (EBA), linear IgA disease (LABD), dermatitis herpetiformis (DH), lichen planus pemphigoides and bullous lupus. This is in contrast to pemphigus and related disorders, which demonstrate intraepidermal acantholysis and a positive Nikolsky sign. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15679
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http://dx.doi.org/10.1111/jdv.15679DOI Listing
September 2019
45 Reads

MPGN Type 3 Associated with Pemphigus Herpetiformis Mimicking PGNMID and Dermatitis Herpetiformis.

Case Rep Nephrol Dial 2019 Jan-Apr;9(1):15-24. Epub 2019 Mar 21.

Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.

A 45-year-old man suffering from dermal blistering disease with proteinuria and hematuria underwent renal biopsy. The renal biopsy specimen suggested proliferative glomerulonephritis with monoclonal IgG deposits under routine light, immunofluorescence and electron microscopy. The staining for IgG subclasses (IgG1 and IgG2) and κ/λ light chain indicated secondary immune complex type MPGN type 3. Read More

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https://www.karger.com/Article/FullText/498939
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http://dx.doi.org/10.1159/000498939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465718PMC
March 2019
25 Reads

[Autoimmune blistering dermatoses in children].

Hautarzt 2019 Apr;70(4):277-282

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Hauptstr. 7, 79104, Freiburg, Deutschland.

Autoimmune blistering skin disorders represent a rare group of autoantibody-induced dermatoses against desmosomal and hemidesmosomal molecules. The common age of onset for pemphigus and pemphigoid, as well as dermatitis herpetiformis, encompasses the adult age, but all these disorders can be observed neonatally and/or during childhood. If the disease occurs postpartum or neonatally, physicians should consider transplacental transmission of pathogenic maternal immunoglobulin G (IgG)-autoantibodies, and both mother and child should be included in the diagnostic work up. Read More

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http://dx.doi.org/10.1007/s00105-019-4379-7DOI Listing
April 2019
30 Reads

Clinical, pathologic, and immunologic features of pemphigus herpetiformis: a literature review and proposed diagnostic criteria.

Int J Dermatol 2019 Sep 22;58(9):997-1007. Epub 2019 Mar 22.

Department of Dermatology, Mayo Clinic, Jacksonville, FL, USA.

Pemphigus herpetiformis (PH), a rare type of pemphigus, is characterized by immunologic findings consistent with pemphigus but with a unique clinical and pathologic presentation. PH was first described as resembling dermatitis herpetiformis clinically, but because of its variable presentation, it can also resemble linear immunoglobulin A bullous dermatosis and bullous pemphigoid. We reviewed reported cases to analyze the most frequent clinical, pathologic, and immunologic characteristics and to propose corresponding diagnostic criteria. Read More

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http://dx.doi.org/10.1111/ijd.14395DOI Listing
September 2019
7 Reads

Treatment Update of Autoimmune Blistering Diseases.

Dermatol Clin 2019 Apr 14;37(2):215-228. Epub 2019 Feb 14.

Department of Medicine, University of Central Florida, Health Sciences Campus at Lake Nona, 2627 Northampton Avenue, Orlando, FL 32827-7408, USA. Electronic address:

The treatment of refractory autoimmune blistering diseases (AIBDs) has always been a challenge. Because randomized controlled trials are lacking, treatment has been based on analysis of anecdotal data. The last 2 decades has seen the use of rituximab become a conventional treatment in the therapeutic armamentarium of AIBDs, leading to its Food and Drug Administration indication for pemphigus vulgaris in 2018. Read More

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http://dx.doi.org/10.1016/j.det.2018.12.003DOI Listing
April 2019
10 Reads

Diagnosis of Autoimmune Blistering Diseases.

Front Med (Lausanne) 2018 2;5:296. Epub 2018 Nov 2.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

Autoimmune skin blistering diseases (AIBD) are characterized by autoantibodies that are directed against structural proteins in the skin and adjacent mucous membranes. Some clinical signs are typical for a specific AIBD, however, correct diagnosis requires the detection of tissue-bound or circulating autoantibodies. The gold standard for diagnosis of AIBD is the detection of autoantibodies or complement component 3 by direct immunofluorescence (DIF) microscopy of a perilesional biopsy. Read More

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http://dx.doi.org/10.3389/fmed.2018.00296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224342PMC
November 2018
39 Reads

Bullous autoimmune dermatoses.

J Dtsch Dermatol Ges 2018 Nov;16(11):1339-1358

Department of Dermatology and Allergology, Marburg University Medical Center, Marburg, Germany.

Pathophysiologically, bullous autoimmune dermatoses are caused by autoantibodies directed against adhesion molecules or structural proteins of the skin and mucous membranes, clinically resulting in blister formation. Depending on the respective target proteins of the autoimmune response and their location in the skin, a distinction is made between intraepidermal (pemphigus disorders), junctional (pemphigoid disorders), and subepidermal (epidermolysis bullosa acquisita, dermatitis herpetiformis) autoimmune blistering diseases. The most common bullous autoimmune dermatosis, bullous pemphigoid is characterized by marked clinical variability and intense pruritus. Read More

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http://dx.doi.org/10.1111/ddg.13688DOI Listing
November 2018
46 Reads

Diagnostik blasenbildender Autoimmundermatosen.

J Dtsch Dermatol Ges 2018 Sep;16(9):1077-1092

Klinik für Dermatologie, Allergologie und Venerologie, Universität zu Lübeck.

Blasenbildende Autoimmundermatosen (BAIDs) sind eine heterogene Gruppe seltener Erkrankungen, die klinisch durch Erosionen und/oder Blasen an Haut und Schleimhäuten charakterisiert sind. BAIDs können in zwei Gruppen eingeteilt werden: Pemphigus-Erkrankungen, die durch intraepidermale Blasenbildung und Autoantikörper gegen desmosomale Proteine wie Desmoglein (Dsg) 1, Dsg3 und Mitglieder der Plakin-Familie charakterisiert sind, sowie subepidermale BAIDs, die Pemphigoid-Erkrankungen und die Dermatitis herpetiformis umfassen. Bei der Dermatitis herpetiformis greifen die Autoantikörper die Transglutaminasen 2 und 3 an, während sie bei Pemphigoid-Erkrankungen gegen Strukturproteine der dermoepidermalen Junktionszone gerichtet sind. Read More

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http://dx.doi.org/10.1111/ddg.13637_gDOI Listing
September 2018
7 Reads

Diagnosis of autoimmune bullous diseases.

J Dtsch Dermatol Ges 2018 Sep;16(9):1077-1091

Department of Dermatology, University of Lübeck, Lübeck, Germany.

Autoimmune bullous disorders (AIBDs) are a heterogeneous group of rare diseases clinically characterized by erosions and/or blisters on the skin and mucous membranes. AIBDs can be categorized into two groups: pemphigus diseases, characterized by intraepidermal blistering and autoantibodies against desmosomal proteins such as desmoglein (Dsg) 1, Dsg3, members of the plakin family, and subepidermal AIBDs, comprised of pemphigoid diseases and dermatitis herpetiformis. Autoantibodies in dermatitis herpetiformis target transglutaminases 2 and 3, while in pemphigoid disease, autoantibodies are directed against structural proteins of the dermal-epidermal junction. Read More

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http://dx.doi.org/10.1111/ddg.13637DOI Listing
September 2018
9 Reads

An annular pruritic eruption.

Int J Dermatol 2019 Mar 3;58(3):283-284. Epub 2018 Aug 3.

Dermatology Department, Habib Thameur Hospital, Tunis, Tunisia.

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http://dx.doi.org/10.1111/ijd.14157DOI Listing
March 2019
5 Reads

Pemphigus herpetiformis in South Tunisia: a clinical expression of pemphigus foliaceus?

Int J Dermatol 2018 Sep 16;57(9):1094-1101. Epub 2018 Jul 16.

Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.

Background: Pemphigus herpetiformis (PH) is a rare subtype of pemphigus combining clinical features of dermatitis herpetiformis and the immunopathologic characteristics of pemphigus. We aimed to analyze the epidemiological, clinical, and immunological presentation and management of the disease in a cohort of south Tunisian patients with a long-term follow-up.

Methods: We included all patients with confirmed PH followed from January 1987 to December 2015 in the dermatology department. Read More

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http://dx.doi.org/10.1111/ijd.14139DOI Listing
September 2018
23 Reads

Thyroid diseases and skin autoimmunity.

Rev Endocr Metab Disord 2018 12;19(4):311-323

Department of Surgical Sciences, "Sapienza" University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy.

The skin is the largest organ of the body, at the boundary with the outside environment. Primarily, it provides a physical and chemical barrier against external insults, but it can act also as immune organ because it contains a whole host of immune-competent cells of both the innate and the adaptive immune systems, which cooperate in eliminating invading pathogens following tissue injury. On the other hand, improper skin immune responses lead to autoimmune skin diseases (AISD), such as pemphigus, bullous pemphigoid, vitiligo, and alopecia. Read More

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http://dx.doi.org/10.1007/s11154-018-9450-7DOI Listing
December 2018
17 Reads

A rare case of pemphigus herpetiformis in a young woman.

G Ital Dermatol Venereol 2020 Apr 16;155(2):229-231. Epub 2018 May 16.

Department of Dermatology, Vittorio Emanuele Polyclinic Hospital, Catania, Italy -

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http://dx.doi.org/10.23736/S0392-0488.18.05866-2DOI Listing
April 2020
6 Reads

Herpetiform pemphigus with characteristic transmission electron microscopic findings of various-sized ballooning vacuoles in keratinocytes without acantholysis.

Br J Dermatol 2019 01 20;180(1):187-192. Epub 2018 Jun 20.

Department of Dermatology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku, Tokyo, 162-8655, Japan.

We report a unique case of a Japanese woman with herpetiform pemphigus (HP) who had IgG autoantibodies reactive with nondesmosomal sites of keratinocytes and presented characteristic transmission electron microscopic (TEM) findings of various-sized vacuoles in keratinocytes without acantholysis. The patient presented with pruritic annular oedematous erythemas with small blisters lining the margins on the trunk and extremities. Histopathological examinations showed intraepidermal blisters with prominent infiltrations of eosinophils. Read More

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http://doi.wiley.com/10.1111/bjd.16554
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http://dx.doi.org/10.1111/bjd.16554DOI Listing
January 2019
2 Reads

Blistering diseases in the mature patient.

Clin Dermatol 2018 Mar - Apr;36(2):231-238. Epub 2017 Oct 3.

Department of Dermatovenereology, University Hospital Center Zagreb and University of Zagreb School of Medicine, Zagreb, Croatia. Electronic address:

Autoimmune blistering diseases (AIBD) are a group of chronic diseases affecting the skin and mucous membranes, with different presentation, clinical course, histologic and immunopathologic findings, and different therapeutic approach. Blisters develop as a result of autoantibodies directed against distinct adhesion structures within desmosomes or within the basement membrane zone. The most common AIBD that develops in the elderly is bullous pemphigoid (previously also named "pemphigoid senilis"), but mature patients can also present with other AIBD as mucous membrane pemphigoid, epidermolysis bullosa acquisita, paraneoplastic pemphigus, pemphigus vulgaris, pemphigus foliaceus, linear IgA dermatosis, and dermatitis herpetiformis. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2017.10.014DOI Listing
September 2018
30 Reads

Pemphigus group: overview, epidemiology, mortality, and comorbidities.

Authors:
Khalaf Kridin

Immunol Res 2018 04;66(2):255-270

Department of Dermatology, Rambam Health Care Campus, POB 9602, 31096, Haifa, Israel.

Pemphigus forms a group of rare autoimmune bullous diseases that affect the skin and mucous membranes. This group has a chronic course leading to high morbidity and mortality. It is characterized by the production of pathogenic autoantibodies directed against different proteins of the desmosome, leading histologically to intraepidermal cleavage, and clinically to vesicles and erosions on the epithelium of the mucous membranes and/or the skin. Read More

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http://dx.doi.org/10.1007/s12026-018-8986-7DOI Listing
April 2018
33 Reads

Pemphigus herpetiformis resistant to first line therapy: a rare case in childhood.

G Ital Dermatol Venereol 2019 Aug 24;154(4):499-501. Epub 2018 Jan 24.

Unit of Dermatology, Department of Surgery and Intensive Care, IRCCS G. Gaslini Children's Hospital, Genoa, Italy -

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http://dx.doi.org/10.23736/S0392-0488.18.05816-9DOI Listing
August 2019
24 Reads

Pemphigus herpetiformis with autoantibodies to desmocollins 1, 2 and 3.

Clin Exp Dermatol 2018 Apr 14;43(3):360-362. Epub 2018 Jan 14.

National Skin Centre, Singapore.

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http://dx.doi.org/10.1111/ced.13355DOI Listing
April 2018
7 Reads

The importance of direct immunofluorescence in pemphigus herpetiformis diagnosis.

An Bras Dermatol 2017 ;92(5 Suppl 1):145-147

Dermatology Outpatient Clinic at Hospital do Açúcar de Alagoas do Centro Universitário Tiradentes, Maceió, Alagoas (AL), Brazil.

Pemphigus herpetiformis is an autoimmune bullous disease, that combines clinical features of dermatitis herpetiformis and linear IgA bullous dermatosis and immunological characteristics of pemphigus, which makes this disease peculiar and this diagnosis rarely suspected in the first evaluation of the patient. The reported case is of a patient with clinically bullous disease similar to dermatitis herpetiformis, whose multiple biopsies were inconclusive, and only after direct immunofluorescence with a pemphigus pattern (intraepidermal intercellular pattern) the confirmation of the diagnosis was possible. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20174510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726706PMC
March 2018
22 Reads

Coexistence of pemphigus herpetiformis with extramammary Paget disease.

Clin Exp Dermatol 2018 Apr 12;43(3):324-326. Epub 2017 Dec 12.

Department of Dermatology and Venereology, China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing, 100029, China.

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http://dx.doi.org/10.1111/ced.13318DOI Listing
April 2018
11 Reads

A comparative study of expression of Fc receptors in relation to the autoantibody-mediated immune response and neutrophil elastase expression in autoimmune blistering dermatoses.

Pol J Pathol 2017;68(2):109-116

Here we investigated the cutaneous CD32A and CD89 expression in relation to the neutrophil elastase (NE) expression and serum level of anti-desmoglein 1 and 3 (DSG1/DSG3) IgG in pemphigus, anti-BP180/BP230 IgG in bullous pemphigoid (BP), anti-gliadin nonapeptides (npG), tissue (tTG), and epidermal transglutaminases (eTG) IgA in dermatitis herpetiformis (DH). The examined material consisted of skin/mucosal tissues and sera. In total, 87 patients were studied. Read More

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http://dx.doi.org/10.5114/pjp.2017.69686DOI Listing
December 2017
30 Reads

Trichoscopy - a useful tool in the preliminary differential diagnosis of autoimmune bullous diseases.

Int J Dermatol 2017 Oct 30;56(10):996-1002. Epub 2017 Aug 30.

Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.

Background: Scalp is a common location of autoimmune bullous diseases. Trichoscopy is a noninvasive method for diagnosing hair and scalp diseases. Data on trichoscopy in autoimmune bullous diseases are limited to the studies on pemphigus including a small number of patients. Read More

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http://doi.wiley.com/10.1111/ijd.13725
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http://dx.doi.org/10.1111/ijd.13725DOI Listing
October 2017
28 Reads

The Value of Direct Immunofluorescence on Proteinase-Digested Formalin-Fixed Paraffin-Embedded Skin Biopsies.

Am J Dermatopathol 2018 Feb;40(2):111-117

Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA.

Direct immunofluorescence (DIF) on frozen tissue (DIF-F) is the method of choice for the identification of immune deposits present in skin and other tissues. DIF can also be performed on formalin-fixed paraffin-embedded tissue (DIF-P) after antigen retrieval with proteases and has proven to be of value in renal pathology. However, its utility in skin biopsies has not been fully examined. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000934DOI Listing
February 2018
41 Reads

Autoimmune Bullous Disease in Childhood.

Indian J Dermatol 2017 Jul-Aug;62(4):440

Department of Dermatology, School of Medicine, Marmara University, Istanbul, Turkey.

Background: Autoimmune bullous disorders (AIBDs) are a heterogeneous group of diseases which are rarely seen in children. Studies concerning the immunobullous diseases in pediatric patients are scarce.

Aims And Objectives: In this study, we aimed to investigate the clinical features and treatment outcomes of AIBDs in children. Read More

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http://dx.doi.org/10.4103/ijd.IJD_366_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527737PMC
August 2017
13 Reads

Evaluation of Autoimmune Bullous Diseases in Elderly Patients in Iran: A 10-Year Retrospective Study.

Skinmed 2017;15(3):175-180. Epub 2017 Jun 1.

Department of Dermatology, Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Autoimmune bullous diseases (ABDs) are uncommon but significant skin disorders with relatively high morbidity and mortality. Some surveys have been carried out to describe the spectrum of ABDs in a region, but this is the first that has focused on ABDs in elderly patients. This study was conducted to determine the clinicoepidemiologic features of ABDs in elderly patients. Read More

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August 2019
26 Reads

Possible triggering factors and comorbidities in newly diagnosed autoimmune bullous diseases.

Turk J Med Sci 2017 Jun 12;47(3):832-840. Epub 2017 Jun 12.

Department of Dermatology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey.

Background/aim: The distribution and the demographic, etiological, and clinical features of autoimmune bullous diseases (ABDs) vary according to geographic regions of the world. The limited number of reported studies in Turkey are mostly retrospective and generally include only pemphigus. The aim of our study was to evaluate the demographic data, clinical features, associated triggering factors, and comorbidities in patients newly diagnosed with ABDs. Read More

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http://dx.doi.org/10.3906/sag-1602-99DOI Listing
June 2017
35 Reads

Correlation between IL36α and IL17 and Activity of the Disease in Selected Autoimmune Blistering Diseases.

Mediators Inflamm 2017 10;2017:8980534. Epub 2017 May 10.

Department of Immunopathology, Chair of Allergy, Immunology and Dermatology, Medical University of Lodz, Lodz, Poland.

Dermatitis herpetiformis (DH), bullous pemphigoid (BP), and pemphigus vulgaris (PV) are autoimmune bullous skin conditions with eosinophilic and neutrophilic infiltrations. While cytokines are crucial for the affinity and activation of different leukocyte cells in the inflammation and blister formation, there are no studies concerning a role of IL-36. The goal of the study was to analyze whether interleukin 36 is involved in pathogenesis of DH, BP, and PV. Read More

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http://dx.doi.org/10.1155/2017/8980534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458385PMC
April 2018
31 Reads

Pediatric Pemphigus Herpetiformis: Case Report and Review of the Literature.

Pediatr Dermatol 2017 May;34(3):342-346

Dermatology Program, Division of Immunology and Allergy, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Pemphigus herpetiformis (PH) is a rare autoimmune bullous condition usually seen in adults and likely underrecognized in children. We describe a 2-year-old girl who presented with a chronic, generalized, blistering rash consistent with pediatric PH based on histology and immunohistochemistry and review the literature. Prognosis is generally more favorable in children than adults. Read More

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http://dx.doi.org/10.1111/pde.13152DOI Listing
May 2017
12 Reads

Case of shift from linear immunoglobulin A bullous dermatosis to pemphigus herpetiformis for a short period of time.

J Dermatol 2017 Feb 5;44(2):189-193. Epub 2016 Nov 5.

Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.

Pemphigus herpetiformis (PH) is a rare variant of pemphigus characterized by erythemas and vesicles, tending to present with annular-shaped lesions. Immunologically, immunoglobulin (Ig)G deposition at the keratinocyte cell surfaces is observed. Linear IgA bullous dermatosis (LABD) is a rare subepidermal blistering disease with linear IgA deposits at the epidermal basement membrane zone (BMZ). Read More

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http://dx.doi.org/10.1111/1346-8138.13677DOI Listing
February 2017
125 Reads

A study of clinical, histopathological and direct immunofluorescence diagnosis in pemphigus group Utility of direct immunofluorescence.

Bratisl Lek Listy 2017 ;118(4):243-249

Aims: To determine the diagnostic accordance between histopathological and direct immunofluorescence diagnosis of patients with autoimmune vesiculobullous skin diseases.

Background: The term pemphigus refers to a group of autoimmune blistering diseases mediated by auto-antibodies directed against desmoglein proteins. The differentiation between the various bullous diseases is important for treatment and prognosis. Read More

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http://dx.doi.org/10.4149/BLL_2017_048DOI Listing
August 2017
18 Reads

Meeting Report of the Pathogenesis of Pemphigus and Pemphigoid Meeting in Munich, September 2016.

J Invest Dermatol 2017 06 5;137(6):1199-1203. Epub 2017 Apr 5.

Institute of Anatomy and Cell Biology, Ludwig-Maximilians-Universität, Munich, Germany.

Autoimmune blistering diseases are a heterogeneous group of about a dozen complex disorders that are characterized by intraepidermal (pemphigus) and subepidermal blistering (pemphigoid diseases and dermatitis herpetiformis). The Pathogenesis of Pemphigus and Pemphigoid Meeting, organized by the Departments of Dermatology in Lübeck and Marburg and the Institute of Anatomy and Cell Biology, Munich, was held in September 2016 in Munich. The meeting brought together basic scientists and clinicians from all continents dedicating their work to autoimmune blistering diseases. Read More

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http://dx.doi.org/10.1016/j.jid.2017.01.028DOI Listing
June 2017
42 Reads

The Inpatient Burden of Autoimmune Blistering Disease in US Children: Analysis of Nationwide Inpatient Sample Data.

Am J Clin Dermatol 2017 Apr;18(2):287-297

Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Suite 1600, 676 N. St. Clair St., Chicago, IL, 60611, USA.

Background: Little is known about the epidemiology of pediatric autoimmune blistering disorders (PAIBD).

Objective: We sought to determine the inpatient burden and comorbidities of PAIBD.

Methods: We analyzed data from the Nationwide Inpatient Sample from 2002 to 2012, which contained a representative 20% sample of all US hospitalizations. Read More

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http://dx.doi.org/10.1007/s40257-017-0257-1DOI Listing
April 2017
63 Reads

Research Techniques Made Simple: Mouse Models of Autoimmune Blistering Diseases.

J Invest Dermatol 2017 01;137(1):e1-e6

Department of Dermatology and Allergology, Philipps University Marburg, Marburg, Germany. Electronic address:

Autoimmune blistering diseases are examples of autoantibody-mediated, organ-specific autoimmune disorders. Based on a genetic susceptibility, such as a strong HLA-class II association, as yet unknown triggering factors induce the formation of circulating and tissue-bound autoantibodies that are mainly directed against adhesion structures of the skin and mucous membranes. Compared with other autoimmune diseases, especially systemic disorders, the pathogenicity of autoimmune blistering diseases is relatively well described. Read More

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http://dx.doi.org/10.1016/j.jid.2016.11.003DOI Listing
January 2017
16 Reads

Concomitant pemphigus herpetiformis and sarcoidosis.

JAAD Case Rep 2016 Nov 3;2(6):436-438. Epub 2016 Dec 3.

Department of Dermatology, Mayo Clinic, Scottsdale, Arizona.

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http://dx.doi.org/10.1016/j.jdcr.2016.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144745PMC
November 2016
7 Reads

Pemphigus herpetiformis-type drug reaction caused by erdosteine containing mucolytic in a child.

Cutan Ocul Toxicol 2017 Sep 23;36(3):302-304. Epub 2016 Nov 23.

b Department of Pathology , Ankara Ataturk Training and Research Hospital , Ankara , Turkey.

Drug-related pemphigus is very rare in children. Erdosteine is a thiol compound having mucoactive, antioxidant, anti-inflammatory, and antitussive effects and is reported to be safe for treatment of acute respiratory tract diseases in children. Herein, we report a 9-year-old boy presented with pemphigus herpetiformis associated with anti-desmoglein 1 antibodies due to erdosteine consumption. Read More

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http://dx.doi.org/10.1080/15569527.2016.1254650DOI Listing
September 2017
93 Reads

Pemphigus Herpetiformis With Autoantibodies to Desmoglein 1 and 3.

Actas Dermosifiliogr 2016 Nov 20;107(9):785-786. Epub 2016 Jun 20.

Unidad de Gestión Clínica de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario Puerta del Mar, Cádiz, España; DERMACHAT (Grupo Español de Consenso on-line en Dermatología).

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http://dx.doi.org/10.1016/j.ad.2016.04.022DOI Listing
November 2016
9 Reads

Incidence of autoimmune bullous diseases in Serbia: a 20-year retrospective study.

J Dtsch Dermatol Ges 2016 Oct;14(10):995-1005

Institute of Social Medicine, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Background And Objectives: While most previous surveys on the clinico-epidemiological features of autoimmune bullous diseases (AIBDs) have predominantly focused on a single disease entity or just one disease group, there have been only few studies examining the incidence of various AIBDs. In the present study, we set out to determine the spectrum of AIBDs, to estimate the incidence of the most common AIBDs, and to examine their temporal trends in Central Serbia over a period of 20 years.

Methods: We retrospectively recruited 1,161 new AIBD cases diagnosed in Central Serbia during the period from January 1991 to December 2010. Read More

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http://dx.doi.org/10.1111/ddg.13081DOI Listing
October 2016
52 Reads
1.820 Impact Factor

Inzidenz von bullösen Autoimmunerkrankungen in Serbien: eine retrospektive Studie über 20 Jahre.

J Dtsch Dermatol Ges 2016 Oct;14(10):995-1006

Institut für Sozialmedizin, Medizinische Fakultät, Universität Belgrad, Belgrad, Serbien.

Hintergrund Und Ziele: Die meisten früheren Arbeiten zu den klinisch-epidemiologischen Merkmalen von bullösen Autoimmunerkrankungen (AIBD) konzentrierten sich vor allem auf eine einzige Krankheitsentität oder nur eine Krankheitsgruppe; nur in wenigen Studien wurde die Inzidenz verschiedener AIBD untersucht. Bei der vorliegenden Studie war es unser Ziel, das gesamte Spektrum der AIBD zu betrachten, die Inzidenz der häufigsten AIBD zu ermitteln und die zeitlichen Trends ihres Auftretens in Zentralserbien über einen Zeitraum von 20 Jahren zu untersuchen.

Methoden: Wir rekrutierten retrospektiv 1161 AIBD-Fälle, die in Zentralserbien von Januar 1991 bis Dezember 2010 neu diagnostiziert wurden. Read More

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http://dx.doi.org/10.1111/ddg.13081_gDOI Listing
October 2016
89 Reads
1.820 Impact Factor