10,048 results match your criteria Pemphigus Foliaceus


Emerging role of immune cell network in autoimmune skin disorders: An update on pemphigus, vitiligo and psoriasis.

Cytokine Growth Factor Rev 2019 Feb 8. Epub 2019 Feb 8.

Department of Biochemistry, All India Institute of Medical Sciences, AIIMS, New Delhi, India. Electronic address:

Autoimmune skin diseases are a group of disorders that arise due to a deregulated immune system resulting in skin tissue destruction. In the majority of these conditions, either autoreactive immune cells or the autoantibodies are generated against self-antigens of the skin. Although the etiology of these diseases remains elusive, biochemical, genetic, and environmental factors such as infectious agents, toxins damage the skin tissue leading to self-antigen generation, autoantibody attack and finally results in autoimmunity of skin. Read More

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http://dx.doi.org/10.1016/j.cytogfr.2019.01.001DOI Listing
February 2019

Childhood pemphigus foliaceus presenting as a polycyclic eruption: Case report and review of the literature.

Pediatr Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

Pemphigus foliaceus (PF) is an autoimmune bullous disorder that has occasionally been reported to present as a polycyclic or arcuate eruption in children. We present a case of childhood PF presenting as an annular and polycyclic eruption, which initially led to a diagnostic conundrum and a delay in diagnosis but which ultimately responded well to therapy with systemic steroids and rituximab infusions. We briefly review the literature on polycyclic presentations of PF in childhood as well as the use of rituximab for pediatric pemphigus. Read More

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http://dx.doi.org/10.1111/pde.13750DOI Listing
February 2019

Infective endocarditis in two patients with pemphigus vulgaris under multiagent immunosuppressive drug therapy: a rare entity to remember in the differential diagnosis of fever of unknown origin.

Dermatol Ther 2019 Feb 13:e12860. Epub 2019 Feb 13.

Department of Dermatology and Venereology, Istanbul Faculty of Medicine, Istanbul University, Istanbul.

Pemphigus vulgaris (PV) is an autoimmune blistering skin disease that, may require multiagent immunosuppressive drug therapies in severe cases. In addition to the well established corticosteroid sparing agents azathioprine, mycophenolate mofetil, and methotrexate, rituximab is being increasingly used alone or in combination in the management of PV. Due to the chronic course of the disease, the cumulative effects of these therapy agents over long follow-up periods may result in various adverse reactions, including bacterial and viral infections. Read More

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http://dx.doi.org/10.1111/dth.12860DOI Listing
February 2019

Improving Treatment Outcome of Pemphigus Vulgaris on Vietnamese Patients by Using Desmoglein Elisa Test.

Open Access Maced J Med Sci 2019 Jan 22;7(2):195-197. Epub 2019 Jan 22.

Psoriasis Eczema Clinic, Melbourne, Australia.

Background: Pemphigus Vulgaris (PV) is a chronic disease, is characterized by the presence of flacid bullous in skin and mucosa. There are 2 main autoantibodies against desmoglein3 (Dsg3) and desmoglein1 (Dsg1).

Aim: The aims of this study were to evaluate the before and after treatment outcome with corticosteroid, using Desmoglein ELISA test. Read More

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http://dx.doi.org/10.3889/oamjms.2019.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364727PMC
January 2019

Pemphigus and mucous membrane pemphigoid: An update from diagnosis to therapy.

Autoimmun Rev 2019 Feb 7. Epub 2019 Feb 7.

Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine "Guido Baccelli", University of Bari Medical School, Bari, Italy. Electronic address:

Pemphigus diseases (PDs) and mucous membrane pemphigoid (MMP) are a group of immune-mediated mucocutaneous disorders clinically characterized by the formation of blisters, erosions and ulcers. The skin and mucous membranes are predominantly affected, with the oropharyngeal mucosa as the initially involved site. Ocular involvement is also a frequent feature of these diseases. Read More

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http://dx.doi.org/10.1016/j.autrev.2019.02.005DOI Listing
February 2019
6 Reads

Cutaneous paraneoplastic syndromes.

Semin Diagn Pathol 2019 Jan 31. Epub 2019 Jan 31.

PRW Laboratories, Charlottesville, VA, United State.

A variety of cutaneous abnormalities can be seen in patients with malignant diseases, some of which are infectious, with others representing direct involvement of the skin by the underlying disorder. Yet another group of lesions can be regarded as associated markers of the malignant process, and, as such, are termed "paraneoplastic." This review considers the latter collection of conditions, grouping them by the generic type of malignancy that is usually linked to the paraneoplasia. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.01.001DOI Listing
January 2019
1 Read

First presentation of Sneddon-Wilkinson disease with unexpected immunoglobulin A gammopathy: A case report and review of the literature.

SAGE Open Med Case Rep 2019 30;7:2050313X19826432. Epub 2019 Jan 30.

University of Saskatchewan, Saskatoon, SK, Canada.

We present a case of Sneddon-Wilkinson disease in a 52-year-old female at her first presentation to dermatology. Outlined in the case are various investigations undertaken at this initial presentation, including rheumatologic and hematologic malignancy markers, which identified immunoglobulin A gammopathy. The systemic and topical therapies used to treat the patient's condition are described, as well as her response to these treatments. Read More

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http://dx.doi.org/10.1177/2050313X19826432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354295PMC
January 2019
2 Reads

[Follicular lymphoma accompanied by paraneoplastic pemphigus and bronchiolitis obliterans: a case report].

Rinsho Ketsueki 2019 ;60(1):7-11

Department of Hematology, Tokyo Medical and Dental University.

A 54-year-old female complained of oral erosion. A flaccid blister appeared on the trunk 2 months after the onset. The high titer of the anti-desmoglein 1 antibody in the absence of Nikolsky's sign led to the diagnosis of pemphigus vulgaris. Read More

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http://dx.doi.org/10.11406/rinketsu.60.7DOI Listing
January 2019
2 Reads

Koebner phenomenon: pemphigus vulgaris following Mohs micrographic surgery.

Dermatol Online J 2019 Jan 15;25(1). Epub 2019 Jan 15.

The Thomas Jefferson University, Department of Dermatology, Philadelphia, Pennsylvania.

Koebnerization of pemphigus vulgaris (PV) is an infrequently reported reaction. We present a 65-year-old man with Koebnerized pemphigus vulgaris after Mohs microscopic surgery for a basal cell carcinoma. We present this case to heighten awareness of the phenomenon in the dermatological community. Read More

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January 2019
6 Reads

Periadrenal inflammatory myofibroblastic tumour: half a decade before cure.

BMJ Case Rep 2019 Feb 1;12(2). Epub 2019 Feb 1.

Anatomic Pathology Unit, Department of Pathology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Malaysia.

A 30-year-old ex-smoker with a background history of childhood asthma presented with worsening shortness of breath despite receiving high doses of oral corticosteroid for pemphigus vulgaris which was diagnosed 5 years earlier. A high-resolution CT examination of the thorax reported non-specific bronchiectatic changes and revealed an incidental suprarenal mass. A subsequent CT scan confirmed a large adrenal mass with areas of necrosis and calcification. Read More

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http://dx.doi.org/10.1136/bcr-2018-225687DOI Listing
February 2019

Long-term evolving profile of childhood autoimmune blistering diseases Retrospective study on 38 children.

J Eur Acad Dermatol Venereol 2019 Jan 31. Epub 2019 Jan 31.

Department of Dermatology, Hospital NECKER ENFANTS-MALADES, Institut Imagine, centre de référence MAGEC, University Paris Descartes- Sorbonne Paris Cité, Paris, France.

Background: Autoimmune bullous dermatosis (AIBDs) in children are uncommon and their long-term evolution remains unknown.

Objective: The aim of this retrospective study was to characterize the long-term prognosis of AIBDs that started during childhood.

Methods: We conducted a monocentric retrospective study, in the French dermatology center, by including all children affected by AIBDs. Read More

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http://dx.doi.org/10.1111/jdv.15456DOI Listing
January 2019

Androgen deprivation therapy for prostate cancer and the risk of autoimmune diseases.

Prostate Cancer Prostatic Dis 2019 Jan 28. Epub 2019 Jan 28.

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.

Background: Androgen deprivation therapy (ADT) has been a mainstay of treatment for advanced prostate cancer (PCa), but limited studies have been performed to investigate the association between ADT and autoimmune diseases.

Methods: We conducted a population-based nationwide cohort study of 17,168 patients newly diagnosed with PCa between 1996 and 2013 using the National Health Insurance Research Database (NHIRD) of Taiwan. Cox proportional hazards models with 1:1 propensity score-matched analysis were used to investigate the association between ADT use and the risk of autoimmune diseases. Read More

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http://www.nature.com/articles/s41391-019-0130-9
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http://dx.doi.org/10.1038/s41391-019-0130-9DOI Listing
January 2019
6 Reads

Synergy among non-desmoglein antibodies contributes to the immunopathology of desmoglein antibody-negative pemphigus vulgaris.

J Biol Chem 2019 Jan 28. Epub 2019 Jan 28.

Dermatology, University of California at Irvine, United States.

Pemphigus vulgaris (PV) is a potentially lethal mucocutaneous blistering disease characterized by IgG autoantibodies (AuAbs) binding to epidermal keratinocytes and inducing this devastating disease. Here, we observed that non-desmoglein (Dsg) AuAbs in serum of individuals with Dsg1/3 AuAb-negative acute PV are pathogenic, since IgGs from these patients induced skin blistering in neonatal mice due to suprabasal acantholysis. Serum levels of AuAbs to desmocollin 3 (Dsc3), M3 muscarinic acetylcholine receptor (M3AR), and secretory pathway Ca/Mn-ATPase isoform 1 (SPCA1) correlated with the disease stage of PV. Read More

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.006743
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http://dx.doi.org/10.1074/jbc.RA118.006743DOI Listing
January 2019
2 Reads

Painful ulceration of the vulva.

Am J Obstet Gynecol 2019 Jan 25. Epub 2019 Jan 25.

Dermatology department, Hospital Regional Universitario de Málaga. Spain.

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http://dx.doi.org/10.1016/j.ajog.2019.01.225DOI Listing
January 2019

RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis.

PLoS Genet 2019 Jan 28;15(1):e1007914. Epub 2019 Jan 28.

Department of Pathology, Stony Brook University, Stony Brook, NY, United States of America.

Cilia-related proteins are believed to be involved in a broad range of cellular processes. Retinitis pigmentosa GTPase regulator interacting protein 1-like (RPGRIP1L) is a ciliary protein required for ciliogenesis in many cell types, including epidermal keratinocytes. Here we report that RPGRIP1L is also involved in the maintenance of desmosomal junctions between keratinocytes. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007914DOI Listing
January 2019

"IgG/IgA Pemphigus in a Patient with a History of Pemphigus Vulgaris: An Example of Epitope Spreading?

J Cutan Pathol 2019 Jan 25. Epub 2019 Jan 25.

Division of Dermatology, University of Virginia Medical Center, Charlottesville, VA.

The dual presentation of IgG and IgA positivity on direct immunofluorescence (DIF) constitutes a rare form of pemphigus. IgG/IgA pemphigus varies widely in clinical and pathologic presentation. Reported sites of involvement range from the trunk as the sole site of involvement to the whole body and oral mucosa as well as the conjunctiva and esophagus . Read More

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http://dx.doi.org/10.1111/cup.13433DOI Listing
January 2019

Enzyme-linked immunosorbent assay as a helpful diagnostic tool for pemphigus erythematosus with equivocal histologic and immunofluorescent findings.

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

Department of Dermatology, University of Central Florida College of Medicine, Orlando, Florida.

Enzyme-linked immunosorbent assay is a sensitive and specific method for the detection of circulating autoantibodies in pemphigus vulgaris and foliaceus. Herein, pemphigus erythematosus with equivocal immunofluorescence and non-diagnostic histology, but confirmed by enzyme-linked immunosorbent assay, is described. As a non-invasive, sensitive, and specific assay with additional utility for monitoring disease activity, this case adds to growing evidence supporting ELISA as the diagnostic method of choice for common and less common variants of pemphigus. Read More

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August 2018
2 Reads

Polycyclic annular presentation of pemphigus vulgaris with an eosinophil predominance in two pregnant patients.

Dermatol Online J 2018 Oct 15;24(10). Epub 2018 Oct 15.

Department of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul.

Pemphigus during pregnancy has a more complicated course owing to the limitations in treatment options and alterations in the severity and presentation of the clinical features. We would like to present two pemphigus vulgaris (PV) cases associated with pregnancy with an unusual clinical appearance exhibiting polycyclic, annular, vesiculobullous plaques with marked eosinophil infiltration in histopathology. To the best of our knowledge pregnancy-associated pemphigus cases with this particular clinical presentation have not been reported in the literature. Read More

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October 2018

Alopecia areata in Tunisia: epidemio-clinical aspects and comorbid conditions. A prospective study of 204 cases.

Int J Dermatol 2019 Jan 24. Epub 2019 Jan 24.

Dermatology Department, Farhat Hached University Hospital, Sousse, Tunisia.

Background: Alopecia areata (AA) is an autoimmune condition that usually presents as patchy, nonscarring hair loss. Autoimmune disorders and atopy are reported as comorbid conditions. We aimed to investigate the demographics, clinical characteristics, and associations of AA in Tunisian patients. Read More

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http://dx.doi.org/10.1111/ijd.14381DOI Listing
January 2019
2 Reads

Nonclassical pemphigus with exclusively IgG anti-desmocollin 3-specific antibodies.

Australas J Dermatol 2019 Jan 22. Epub 2019 Jan 22.

Department of Dermatology, Hospital Clínic de Barcelona, Barcelona, Spain.

We describe a patient with nonclassical clinical and histopathological features of pemphigus with exclusively IgG antibodies against desmocollin (Dsc) 3 detected by enzyme-linked immunosorbent assay of recombinant eukaryotic protein of Dsc1-Dsc3. The absence of antibodies against other known targets, such as desmogleins, reinforces the role of anti-Dsc antibodies in the pathophysiology of atypical pemphigus. Read More

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http://dx.doi.org/10.1111/ajd.12991DOI Listing
January 2019
1 Read

Evaluation of Ear, Nose, and Throat Involvement in Pemphigus Vulgaris in Comparison with Pemphigus Severity Scoring Systems: A Cross-sectional Study.

Acta Dermatovenerol Croat 2018 Dec;26(4):283-288

Aslı Bilgic Temel, MD, Beysehir State Hospital Dermatology Clinic, Beysehir, 42700 Konya, Turkey;

Pemphigus vulgaris (PV) frequently affects the mucous membranes of the ear, nose, and throat (ENT). Since ENT examination is not a routinely performed procedure, the exact involvement of PV remains unrecognized. The available severity scoring systems (Pemphigus Disease Area Index (PDAI) and Autoimmune Bullous Skin Disorder Intensity Score (ABSIS)) for PV do not include a full ENT examination. Read More

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December 2018
1 Read

Dsg1 deficiency causes lethal skin blistering.

J Invest Dermatol 2019 Jan 17. Epub 2019 Jan 17.

Ludwig-Maximilians-Universität (LMU) Munich, Institute of Anatomy and Cell Biology, Department I, Pettenkoferstrasse 11, D-80336 Munich / Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.01.002DOI Listing
January 2019
1 Read

"Change over time in the treatment of pemphigus vulgaris between 2004 and 2016 in Iran": A multiple cross-sectional study.

Dermatol Ther 2019 Jan 18:e12827. Epub 2019 Jan 18.

Department of Dermatology, Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1111/dth.12827DOI Listing
January 2019
2 Reads
1.478 Impact Factor

A novel splice-site mutation in the ATP2C1 gene of a Chinese family with Hailey-Hailey disease.

J Cell Biochem 2019 Mar 11;120(3):3630-3636. Epub 2018 Sep 11.

Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Hailey-Hailey disease (HHD), also known as familial benign chronic pemphigus, is an autosomal dominant genodermatosis. It is characterized by erosions, blisters and erythematous plaques at sites of friction or intertriginous areas. The pathogenic gene of HHD has been revealed as the ATPase secretory pathway Ca transporting 1 gene ( ATP2C1), which encodes the protein, secretory pathway Ca /Mn -ATPase 1 (SPCA1). Read More

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http://doi.wiley.com/10.1002/jcb.27640
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http://dx.doi.org/10.1002/jcb.27640DOI Listing
March 2019
11 Reads

Long non-coding RNA polymorphisms influence susceptibility to endemic pemphigus foliaceus.

Br J Dermatol 2019 Jan 17. Epub 2019 Jan 17.

Laboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná, Curitiba, Brazil.

Background: Pemphigus foliaceus (PF) is an epidermal autoimmune disease, characterized by the presence of autoantibodies against the desmosomal protein desmoglein 1. Genetic and environmental factors contribute to PF, a complex disease that is endemic in Brazil and Colombia and neighbouring countries, and in Tunisia. Long non-coding RNAs (lncRNAs) may participate in gene regulation by interacting with DNA, proteins, and other RNAs. Read More

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http://dx.doi.org/10.1111/bjd.17640DOI Listing
January 2019
3 Reads

Decreased recognition of paraneoplastic pemphigus in patients previously treated with anti-CD 20 monoclonal antibodies.

Br J Dermatol 2019 Jan 15. Epub 2019 Jan 15.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.

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http://dx.doi.org/10.1111/bjd.17577DOI Listing
January 2019
1 Read

Hailey-Hailey-Like Pattern of Acantholysis on the Scalp Should Raise the Possibility of Incipient Pemphigus Vulgaris.

Am J Dermatopathol 2019 Jan 11. Epub 2019 Jan 11.

Ackerman Academy of Dermatopathology, New York, NY.

Hailey-Hailey disease (familial benign chronic pemphigus) is a genodermatosis with a typical clinical presentation of macerated plaques involving intertriginous areas of the body and affects multiple family members. Epidermal acanthosis, incipient, and completed acantholysis of many of the spinous keratinocytes of the epidermis and foci of dyskeratosis are well-recognized histologic findings. We have observed solitary lesions on the "scalp" of patients having a Hailey-Hailey-like pattern, and not the suprabasilar clefting of pemphigus represents the first manifestation of pemphigus vulgaris, which was confirmed with direct immunofluorescence in all our patients. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001298DOI Listing
January 2019
4 Reads

The relationship between pemphigus and systemic lupus erythematosus: a cross-sectional study, systematic review, and meta-analysis.

Immunol Res 2019 Jan 14. Epub 2019 Jan 14.

Department of Quality Measurements and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel.

The coexistence of pemphigus and systemic lupus erythematosus (SLE) had been reported anecdotally. Anti-desmoglein (Dsg)1 and anti-Dsg3 antibodies were detected concomitantly with antinuclear autoantibodies among blood donors. The aim of the current study was to study the association between pemphigus and SLE in Israeli patients and to synthesize existing data on this association in the current literature. Read More

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http://link.springer.com/10.1007/s12026-019-9065-4
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http://dx.doi.org/10.1007/s12026-019-9065-4DOI Listing
January 2019
5 Reads

Etanercept for pemphigus vulgaris.

G Ital Dermatol Venereol 2019 Jan 9. Epub 2019 Jan 9.

Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.23736/S0392-0488.18.06204-1DOI Listing
January 2019
2 Reads

Oral pemphigus without skin lesions treated with pulse steroid therapy.

J Indian Soc Periodontol 2018 Nov-Dec;22(6):551-554

Department of Periodontology, Mahatma Gandhi Postgraduate Institute of Dental Sciences, Puducherry, India.

Pemphigus is an autoimmune disease affecting the skin and mucosae. Oral lesions are common and sometimes are the only manifestations of the disease. The clinical presentations of pemphigus might mimic other vesiculobullous lesions of the oral cavity. Read More

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http://dx.doi.org/10.4103/jisp.jisp_345_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305090PMC
January 2019

Feline pemphigus foliaceus: original case series and a comprehensive literature review.

BMC Vet Res 2019 Jan 9;15(1):22. Epub 2019 Jan 9.

Murdoch University Veterinary Hospital, School of Veterinary and Biomedical Science, Murdoch University, Murdoch, WA, Australia.

Background: Since the first description of feline pemphigus foliaceus (PF) more than 30 years ago, numerous case reports have been published, while larger case series have remained rare. This large body of information, if extrapolated, could address clinical discrepancies and expand our knowledge about the treatment of feline PF. This manuscript reviews cases of feline PF published between 1950 and 2016 and adds additional 35 original cases to provide further insight into the clinical aspect and treatment outcome of this disease. Read More

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https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-
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http://dx.doi.org/10.1186/s12917-018-1739-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327590PMC
January 2019
12 Reads

Mucosal involvement is a risk factor for poor clinical outcomes and relapse in patients with pemphigus treated with rituximab.

Dermatol Ther 2019 Jan 8:e12814. Epub 2019 Jan 8.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Many studies have reported the outcome of rituximab use in pemphigus but studies regarding the clinical risk factors for poor clinical outcomes or relapse are lacking. To clarify the risk factors for poor clinical outcomes or relapse in patients with pemphigus treated with rituximab, a retrospective chart analysis was performed on patients with pemphigus who were treated with rituximab in the dermatology clinic of Seoul National University Hospital. Forty patients with pemphigus were treated with rituximab, of which 39 (97. Read More

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http://doi.wiley.com/10.1111/dth.12814
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http://dx.doi.org/10.1111/dth.12814DOI Listing
January 2019
4 Reads

Antibody reactive to a novel autoantigen on the nondesmosomal keratinocyte surfaces leads to herpetiform pemphigus.

Authors:
H Yuan M Pan

Br J Dermatol 2019 Jan;180(1):22

Department of Dermatology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 200025.

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http://dx.doi.org/10.1111/bjd.16888DOI Listing
January 2019

Pemphigus vulgaris - A report of three cases and review of literature.

J Family Med Prim Care 2018 Sep-Oct;7(5):1109-1112

Department of Oral Medicine and Radiology, Haldia Institute of Dental Sciences and Research (HIDSAR), Balughata, Haldia, West Bengal, India.

Pemphigus vulgaris (PV) is an autoimmune, potentially life-threatening disease causing blisters and erosions of the skin and mucous membranes associated with intraepithelial acantholysis. The underlying mechanism responsible for causing intraepithelial lesions is the binding of immunoglobulin G autoantibodies to desmoglein 3, a transmembrane glycoprotein adhesion molecule present on desmosomes. Histological features comprise intraepithelial cleft and Tzanck cells. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_133_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259552PMC
January 2019

Successful Treatment of Pemphigus Vulgaris With Ofatumumab

J Drugs Dermatol 2018 Dec;17(12):1338-1339

Rituximab is a chimeric anti-CD20 monoclonal antibody that is very effective in treating patients with pemphigus vulgaris. Though infrequent, the development of human anti-chimeric antibodies in patients receiving rituximab results in loss of efficacy. Ofatumumab is a second-generation fully-human anti-CD20 monoclonal antibody currently used to treat chronic lymphocytic leukemia. Read More

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December 2018
4 Reads

Rituximab therapy for refractory autoimmune bullous diseases: A multicenter, open-label, single-arm, phase 1/2 study on 10 Japanese patients.

J Dermatol 2019 Feb 26;46(2):124-130. Epub 2018 Dec 26.

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.

This was a multicenter study of rituximab, a chimeric monoclonal immunoglobulin G antibody directed against CD20, for the treatment of refractory autoimmune bullous diseases (pemphigus and pemphigoid). Ten patients (three with pemphigus vulgaris, six with pemphigus foliaceus and one with bullous pemphigoid) were treated with a single cycle of rituximab (four weekly infusions at a dose of 375 mg/m of body surface area). The primary end-points were the number of serious adverse events and rate of complete remission at 40 weeks. Read More

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http://dx.doi.org/10.1111/1346-8138.14732DOI Listing
February 2019
2 Reads

Clinical and immunological features of pemphigus relapse.

Br J Dermatol 2018 Dec 26. Epub 2018 Dec 26.

Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Background: More than half of pemphigus patients experience relapse during the disease course. However, the risk factors and clinical and immunological characteristics of relapse remain largely unclear.

Objective: To elucidate risk factors and clinical features of pemphigus relapse. Read More

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http://dx.doi.org/10.1111/bjd.17591DOI Listing
December 2018

Update on immunogenetics of Tunisian endemic pemphigus foliaceus.

J Leukoc Biol 2019 Feb 21;105(2):257-265. Epub 2018 Dec 21.

Department of Dermatology, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia.

Pemphigus foliaceus (PF) is an autoimmune blistering skin disease characterized by the presence of bullous skin lesions, the absence of mucous tissue involvement, and the production of auto-antibodies directed against a keratinocyte transmembrane protein localized in the desmosome and member of the cadherines, desmoglein 1. These pathogenic auto-antibodies are responsible for the intra-epidermal formation of blisters through the loss of keratinocyte adhesion, the so-called acantholysis process. The endemic form of PF observed in the south of Tunisia is characterized by a significantly higher incidence rate compared to the sporadic form in northern countries, occurrence mainly in young women and the absence of cases during childhood. Read More

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http://dx.doi.org/10.1002/JLB.MR0318-132RDOI Listing
February 2019
2 Reads

[Pemphigus vulgaris in pediatrics: A case report].

Rev Chil Pediatr 2018 Oct;89(5):650-654

Asociación Española, Montevideo, Uruguay.

Introduction: pemphigus vulgaris is a serious and infrequent disease in children. Its timely diagnosis and treatment allows modifying its prognosis. The objective is to describe its clinical characteristics, and the diagnostic and therapeutic approach of this uncommon autoimmune blistering disease in children. Read More

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http://dx.doi.org/10.4067/S0370-41062018005000708DOI Listing
October 2018
1 Read

Bullous pemphigoid in adolescence.

Pediatr Dermatol 2018 Dec 19. Epub 2018 Dec 19.

Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania.

Bullous pemphigoid (BP) is the most common autoimmune blistering disease affecting the elderly but is quite rare in childhood. The majority of pediatric cases have been reported during early childhood. Adolescence is divided into three phases: early (10-13 years), middle (14-17), and late (18-21). Read More

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http://doi.wiley.com/10.1111/pde.13717
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http://dx.doi.org/10.1111/pde.13717DOI Listing
December 2018
2 Reads

sepsis in an immunosuppressed patient with pemphigus vulgaris.

BMJ Case Rep 2018 Dec 17;11(1). Epub 2018 Dec 17.

Unit of Dermatology, University of Padua, Padua, Italy.

Pemphigus vulgaris is an autoimmune bullous disease that involves the skin and mucous membranes. Current therapies aim to decrease antibody production by means of the use of systemic corticosteroids, immunosuppressive agents and, recently, rituximab, an anti-CD20 monoclonal antibody. However, the chronic immune suppression could entail complications, like infections and secondary malignancies. Read More

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http://dx.doi.org/10.1136/bcr-2018-227091DOI Listing
December 2018

Biological therapy of autoimmune blistering diseases.

Authors:
Mauro Alaibac

Expert Opin Biol Ther 2019 Feb 18;19(2):149-156. Epub 2018 Dec 18.

a Unit of Dermatology , University of Padua , Padua , Italy.

Introduction: Autoimmune blistering skin diseases are a group of disorders subdivided according to the location of blister formation: intraepidermal blistering in the pemphigus group and subepidermal in the pemphigoid group. These conditions are clinically heterogeneous and are treated with systemic corticosteroids and/or other forms of immunosuppression on the basis of clinical subtype and disease severity. These approaches may not be effective for the induction and maintenance of clinical response or need to be stopped because of intolerable side effects. Read More

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http://dx.doi.org/10.1080/14712598.2019.1559291DOI Listing
February 2019
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The impact of human herpesvirus detection in pemphigus vulgaris.

Australas J Dermatol 2018 Dec 9. Epub 2018 Dec 9.

Department of Dermatology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ajd.12977
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http://dx.doi.org/10.1111/ajd.12977DOI Listing
December 2018
13 Reads

Desmogleins as signaling hubs regulating cell cohesion and tissue/organ function in skin and heart - EFEM lecture 2018.

Authors:
Jens Waschke

Ann Anat 2018 Dec 7. Epub 2018 Dec 7.

Institute of Anatomy, Faculty of Medicine, LMU Munich, Pettenkoferstr. 11, 80336 Munich, Germany. Electronic address:

Cell-cell contacts are crucial for intercellular cohesion and formation of endothelial and epithelial barriers. Desmosomes are the adhesive contacts providing mechanical strength to epithelial intercellular adhesion and therefore are most abundant in tissues subjected to high mechanical stress such as the epidermis and heart muscle. Desmogleins (Dsg) besides intercellular adhesion serve as signalling hubs regulating cell behaviour. Read More

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http://dx.doi.org/10.1016/j.aanat.2018.11.006DOI Listing
December 2018
2 Reads

The incidence of herpes zoster in cutaneous lupus erythematosus (CLE), dermatomyositis (DM), pemphigus vulgaris (PV), and bullous pemphigoid (BP).

Authors:
Eden Lake

J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Loyola Univ Medical Center Dermatology, 321 N La Grange Rd, La, Grange Park, IL. Electronic address:

The incidence of zoster is increased in many autoimmune diseases. This study found a significantly increased zoster incidence in dermatomyositis and cutaneous lupus erythematosus compared with a control group.Physicians should be aware of this risk and consider administering the vaccine against zoster to these patients if not contraindicated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183297
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http://dx.doi.org/10.1016/j.jaad.2018.10.077DOI Listing
December 2018
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Pemphigus and hematologic malignancies: A population-based study of 11,859 patients.

Authors:
Eden Lake

J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Loyola University Medical Center Dermatology, 321 N La Grange Rd, La Grange Park, IL. Electronic address:

•Hematologic malignancies have been reported sporadically in patients with pemphigus.•In the current study, significant associations were observed between pemphigus and chronic leukemia, multiple myeloma, and non-Hodgkin lymphoma.•Further research is needed to confirm these findings in other cohorts. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183297
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http://dx.doi.org/10.1016/j.jaad.2018.10.076DOI Listing
December 2018
16 Reads

Heritable phytohormone profiles of poplar genotypes vary in resistance to a galling aphid.

Mol Plant Microbe Interact 2018 Dec 6. Epub 2018 Dec 6.

University of Toledo College of Natural Sciences and Mathematics, 385199, Department of Environmental Sciences, Toledo, Ohio, United States.

Insect galls are highly specialized structures arising from atypical development of plant tissue induced by insects. Galls provide the insect enhanced nutrition and protection against natural enemies and environmental stresses. Galls are essentially plant organs formed by an intimate biochemical interaction between the gall-inducing insect and its host-plant. Read More

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https://apsjournals.apsnet.org/doi/10.1094/MPMI-11-18-0301-R
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http://dx.doi.org/10.1094/MPMI-11-18-0301-RDOI Listing
December 2018
10 Reads

[Immunoadsorption in dermatology].

Hautarzt 2019 Jan;70(1):51-63

Klinik für Dermatologie, Allergologie und Venerologie, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Autoimmmune bullous diseases are mediated by pathogenetically relevant autoantibodies against components of the epidermis and/or superficial mucous membranes (in pemphigus) and structural proteins of the dermal-epidermal junction (in pemphigoid diseases). Using immunoadsorption (IA), an already well-established procedure in cardiac and rheumatic disorders, antibodies can be removed from the plasma. At present, most data on the adjuvant use of IA in dermatology are derived from patients with severe and/or refractory pemphigus vulgaris or pemphigus foliaceus and also from patients with pemphigoid diseases. Read More

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http://dx.doi.org/10.1007/s00105-018-4315-2DOI Listing
January 2019
3 Reads

Altered levels of focal adhesion and extracellular matrix-receptor interacting proteins were identified in Hailey-Hailey disease by quantitative iTRAQ proteome analysis.

J Cell Biochem 2019 Mar 3;120(3):3801-3812. Epub 2018 Dec 3.

Department of Dermatology, The Second Hospital of Xi'an Jiaotong University, Xi'an, China.

Benign chronic familial pemphigus or Hailey-Hailey disease (HHD, OMIM 169600) is a rare, autosomal dominant blistering skin disorder characterized by suprabasal cell separation (acantholysis) of the epidermis. To date, the proteomic changes in skin lesions from HHD patients has not been reported yet. In this study, a sample of skin lesions from HHD patients was collected for isobaric tags for relative and absolute quantitation to analyze proteome changes compared with unaffected individuals. Read More

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http://dx.doi.org/10.1002/jcb.27662DOI Listing
March 2019
7 Reads