10,963 results match your criteria Pemphigus Foliaceus

Pemphigus vegetans of Hallopeau masquerading as acrodermatitis continua suppurativa.

Indian J Dermatol Venereol Leprol 2021 May 8:1-3. Epub 2021 May 8.

Department of Dermatology, Venereology and Leprosy, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India.

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Cutaneous manifestations related to the COVID-19 pandemic: a review article.

Cutan Ocul Toxicol 2021 Jun;40(2):168-174

Dermatology Department of Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Skin lesions are either caused by COVID-19 disease or they can be due to other driving forces related to the COVID-19 pandemic.

Aim: Considering the fact that the reported data in different articles for the type and prevalence of skin manifestations related to the COVID-19 pandemic are inconsistent, we have described the mechanism and type of skin lesions related to the COVID-19 pandemic.

Methods: In this review article, we have searched the Medline database (PubMed) for the combination of the following key terms "Dermatological Manifestation", "cutaneous Manifestation", "Skin Manifestation", "COVID-19", "SARS-CoV-2". Read More

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Rituximab versus Mycophenolate Mofetil in Patients with Pemphigus Vulgaris.

N Engl J Med 2021 May 19. Epub 2021 May 19.

From the Perelman School of Medicine, University of Pennsylvania, and the Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia (V.P.W.); the Department of Dermatology, Rouen University Hospital and INSERM 1234, Normandie Université, Rouen (P.J.), and the Department of Dermatology, Groupe Hospitalier Paris Seine-Saint-Denis, Assistance Publique-Hôpitaux de Paris and INSERM Unité Mixte de Recherche 1125, Bobigny (F.C.) - all in France; the Sackler School of Medicine, Tel Aviv University, Tel Aviv, and Rabin Medical Center, Petah Tikva - both in Israel (D.M.); the Department of Dermatology, University of California, Davis, School of Medicine, Sacramento (E.M.), and Genentech, South San Francisco (A.K., D.M.C.) - both in California; Roche Products, Welwyn Garden City, United Kingdom (P.L.); F. Hoffmann-La Roche, Basel, Switzerland (L.G.); and Roche Products, Mississauga, ON, Canada (P.P.).

Background: Rituximab and mycophenolate mofetil are used to treat pemphigus vulgaris, but they have not been adequately compared in clinical trials.

Methods: In a randomized, controlled trial, we assigned patients with moderate-to-severe pemphigus vulgaris in a 1:1 ratio to receive intravenous rituximab (1000 mg on days 1, 15, 168, and 182) or oral mycophenolate mofetil (2 g per day), in addition to an oral glucocorticoid administered on the same tapering schedule in the two groups. The primary end point was sustained complete remission at week 52, defined as the healing of lesions with no new active lesions, as reflected by a Pemphigus Disease Area Index (PDAI) activity score of 0 (on a scale of 0 to 250, with higher scores indicating greater disease severity), for at least 16 weeks without the use of glucocorticoids. Read More

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De-escalation of anti-CD20 monoclonal antibody (Rituximab) protocols in Pemphigus Vulgaris - a systematic review.

Expert Opin Biol Ther 2021 Jun 11:1-11. Epub 2021 Jun 11.

Dermatology Department, The Royal Melbourne Hospital, Melbourne, Australia.

: This review assesses current evidence supporting dose de-escalated rituximab therapy in pemphigus vulgaris, compared to standard protocols. Primary outcome measures were remission and relapse rates. Adverse effects, cumulative steroid dosages, and serological markers of disease activity were also reported. Read More

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Comparison of the EUROIMMUN Dermatology Profile ELISA to the novel BIOCHIP Mosaic 7 for the diagnosis of immunobullous skin disease.

Australas J Dermatol 2021 May 26. Epub 2021 May 26.

Department of Dermatology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.

Background: The BIOCHIP is an indirect immunofluorescence diagnostic investigation which identifies multiple autoantibodies with a mosaic panel of target antigen-specific substrates in a single incubation field. The EUROIMMUN Dermatology Profile ELISA allows simultaneous investigation of the six most important autoantibodies in bullous autoimmune dermatoses. Evaluation of the BIOCHIP Mosaic 7, compared to that of the EUROIMMUN Dermatology Profile ELISA, when used as a diagnostic investigation in pemphigus and pemphigoid, was undertaken in an Australian cohort. Read More

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A Case of Paraneoplastic Pemphigus as a Preceding Manifestation of Underlying Follicular Lymphoma Treated with R-CHOP.

Ann Dermatol 2021 Jun 4;33(3):271-274. Epub 2021 May 4.

Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea.

Paraneoplastic pemphigus is a rare, life-threatening disorder associated with an underlying neoplasm, which presents with painful stomatitis and polymorphous skin lesions. Successful diagnosis of paraneoplastic pemphigus can lead to the diagnosis and treatment of the underlying malignancy. However, involvement of the respiratory system is typically unresponsive to treatment. Read More

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Pemphigus Vulgaris After COVID-19: a Case of Induced Autoimmunity.

SN Compr Clin Med 2021 May 27:1-5. Epub 2021 May 27.

Department of Pathology, Federal University of Pernambuco, Recife, PE Brazil.

Bullae autoimmune diseases can be induced by environmental factors in a genetically susceptible individual, and viruses may be important triggers for this process. Coronavirus disease 2019 (COVID-19) is a multisystemic disease known for developing many types of skin lesions. However, little is known about post-COVID-19 manifestations. Read More

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Evaluation of non-endemic pemphigus foliaceus in a large series of patients: a single-center retrospective study from Turkey focuses on the relapses.

An Bras Dermatol 2021 May 28. Epub 2021 May 28.

Department of Dermatology and Venereology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Background: Pemphigus foliaceus is exceedingly rare around the world, except within the few regions where it occurs as an endemic variant. Various factors can trigger immune mechanisms that induce pemphigus foliaceus or worsen its course.

Objective: To determine the demographic and clinical characteristics of the patients with pemphigus foliaceus in a large series from a non-endemic country, investigate the triggering factors, and seasonal patterns. Read More

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A case of mucosa-predominant pemphigus vulgaris with anti-desmocollin 2, 3 antibody positive with ocular symptoms.

Clin Exp Dermatol 2021 May 31. Epub 2021 May 31.

Division of Cutaneous Science, Department of Dermatology, Nihon University School of Medicine, Tokyo, Japan.

A 24-year-old Japanese female presented to our department complaining of redness of eyes and pain in the mouth and throat. She had no particular medical history. She was treated in dentistry of our hospital, but there was no improvement. Read More

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Modifications of the BAFF/BAFF-Receptor Axis in Patients With Pemphigus Treated With Rituximab Versus Standard Corticosteroid Regimen.

Front Immunol 2021 14;12:666022. Epub 2021 May 14.

Normandie University, UNIROUEN, Inserm, U1234, FOCIS Center of Excellence PAn'THER, Rouen University Hospital, Department of Immunology and Biotherapy, Rouen, France.

The efficacy of the B-cell-depleting agent rituximab has been reported in immune diseases but relapses are frequent, suggesting the need for repeated infusions. The B-cell activating factor (BAFF) is an important factor for B cell survival, class switch recombination and selection of autoreactive B cells, as well as maintaining long-lived plasma cells. It has been hypothesized that relapses after rituximab might be due to the increase of serum BAFF levels. Read More

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[The role Epstein-Barr virus played in the outcome of skin diseases].

J W Lu Y Lu

Zhonghua Yi Xue Za Zhi 2021 Jun;101(20):1458-1462

Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Since the discovery of Epstein-Barr (EB) virus from the cultured cells in Burkitt lymphoma tissue in African children in 1964, we have gradually taken in its oncogenicity and the link between this virus and multiple mucocutaneous diseases. This review exhibits the process of EB virus infection and summarizes the clinical manifestations and varied prognosis of EB virus-associated skin diseases. The cases of common skin diseases including psoriasis, dermatomyositis, pemphigus, pemphigoid, parapsoriasis, atopic dermatitis, urticaria, systemic lupus erythematosus, scleroderma, panniculitis,erythema multiforme and vasculitis coinciding with EB virus infection were collected for the analysis of their EB virus-associated complications, treatments and outcomes. Read More

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A Case of Severe Refractory Pemphigus Vulgaris in a Patient With Stable Esophageal Malignancy.

Cureus 2021 Apr 20;13(4):e14576. Epub 2021 Apr 20.

Rheumatology, Rutgers University, Newark, USA.

Pemphigus is a broad term that is used to describe a group of bullous autoimmune diseases affecting the skin and mucous membranes; the pathogenesis involves autoantibodies directed against various cell junction desmosomal proteins. In patients with a history of malignancy who present with bullous lesions, the differential diagnosis may include, but is not limited to, paraneoplastic pemphigus (PNP) and pemphigus vulgaris (PV) secondary to a primary autoimmune process, or induced by chemotherapy or radiation therapy. In this report, we present a case of refractory PV in a patient with stable esophageal cancer, five years after undergoing radiation therapy. Read More

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Long-term experience with rituximab therapy for treatment-resistant moderate-to-severe pemphigus.

J Dermatolog Treat 2021 Jun 8:1-8. Epub 2021 Jun 8.

Dermatology and Venereology, Akdeniz University School of Medicine, Antalya, Turkey.

Background: Rituximab appears to be effective for treating pemphigus, although there are limited long-term data.

Methods: This retrospective single-center study evaluated patients with conventional treatment-resistant pemphigus who received rituximab during September 2010-December 2019. The first rituximab cycle was based on the rheumatoid arthritis protocol in all patients except one patient, and additional single doses (500 mg or 1000 mg) were administered after clinical and/or serological relapse. Read More

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Utility of Direct Immunofluorescence in Cutaneous Autoimmune Bullous Disorders.

Cureus 2021 Apr 19;13(4):e14562. Epub 2021 Apr 19.

Department of Pathology, Maharishi Markandeshwar University, Ambala, IND.

Background Autoimmune bullous disorders (AIBD) are a heterogeneous group of disorders with substantial clinical overlap associated with blistering of skin or mucosa. Aims The present study aimed to study the histopathological spectrum and evaluate the utility of direct immunofluorescence (DIF) on snap-frozen and paraffin-embedded sections in resolving the differential diagnosis of AIBD and connective tissue disorders of the skin. We also compared the efficacy of DIF on paraffin versus the snap-frozen sections in diagnosing AIBD. Read More

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Paraneoplastic pemphigus associated with post-transplant lymphoproliferative disorder after small bowel transplantation.

Pediatr Transplant 2021 May 20:e14023. Epub 2021 May 20.

Department of Pediatric Gastroenterology, University Medical Center Groningen, Groningen, The Netherlands.

Background: PNP is a malignancy-associated autoimmune mucocutaneous syndrome due to autoantibodies against plakins, desmogleins, and other components of the epidermis and basement membrane of epithelial tissues. PNP-causing malignancies comprise mainly lymphoproliferative and hematologic neoplasms. PNP is extremely rare, especially in children. Read More

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Case of pemphigoid vegetans with autoantibodies against the BP180 C-terminal domain and BP230 antigen.

J Dermatol 2021 May 18. Epub 2021 May 18.

Department of Dermatology, Ehime University Graduate School of Medicine, Toon, Japan.

Pemphigoid vegetans is a rare variant of bullous pemphigoid characterized by vegetative and purulent lesions of the groin, axillae, thighs, hands, eyelids, and perioral regions. The clinical features and histological findings of pemphigus vegetans and immunohistochemical characteristics of bullous pemphigoid are shown. An 86-year-old woman presented with vegetative lesions in the vulva and groin, and blisters on the head, neck, axillae, and thighs. Read More

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Survival of Adjuvant Drugs for Treatment of Pemphigus: A Population-based Cohort Study.

Acta Derm Venereol 2021 May 18. Epub 2021 May 18.

Lübeck Institute of Experimental Dermatology , University of Lübeck, Ratzeburger Allee 160, DE-23562 Lübeck, Germany. E-mail:

Drug survival reflects the real-life efficacy and safety of therapeutic agents. Evidence regarding the durability of adjuvant agents in the treatment of pemphigus is sparse. The aims of this study were to investigate the survival of adjuvant agents used to manage patients with pemphigus, and to identify predictors of treatment dropout. Read More

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Bone cement implantation syndrome during hip replacement in a patient with pemphigus and Parkinson's disease: A case report.

World J Clin Cases 2021 May;9(14):3342-3349

Department of Anesthesiology, China Japan Union Hospital of Jilin University, Changchun 130021, Jilin Province, China.

Background: Bone cement implantation syndrome (BCIS) is characterized by hypotension, arrhythmia, diffuse pulmonary microvascular embolism, shock, cardiac arrest, any combination of these factors, or even death following bone cement implantation.

Case Summary: An 80-year-old patient with pemphigus and Parkinson's disease underwent total hip replacement under spinal subarachnoid block and developed acute pulmonary embolism after bone cement implantation. The patient received mask mechanical ventilation with a continuous intravenous infusion of adrenaline (2 μg/mL) at a rate of 30 mL/h. Read More

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Immunobullous disease.

Clin Med (Lond) 2021 05;21(3):162-165

St John's Institute of Dermatology, London, UK

Immunobullous diseases are blistering cutaneous disorders that are caused by pathogenic antibodies binding to protein targets within the skin. There are a range of immunobullous disorders with characteristic morphology that relates to the structural properties of the target protein. In this article we will describe the pathogenesis, clinical features and treatment of the most common immunobullous disorders. Read More

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Pemphigus vegetans developing after Mohs micrographic surgery and cryotherapy.

An Bras Dermatol 2021 May 15. Epub 2021 May 15.

Department of Dermatology, School of Medicine, Northwestern University Feinberg, Chicago, USA.

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Pathogenic role of ST18 in pemphigus vulgaris.

T Hashimoto

Br J Dermatol 2021 Jun 17;184(6):1001-1002. Epub 2021 May 17.

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

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Post-cesarean section pemphigus vegetans in a young woman treated with methylprednisolone and thalidomide.

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Feb 11:4573. Epub 2021 Feb 11.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Pemphigus vegetans is a rare variant of pemphigus vulgaris. Here, we report a rare case of postparturition pemphigus vegetans in a young woman without any prior medical history. The patient presented with extensive oral mucosal erosion, conjunctivitis, and fingernail dystrophy. Read More

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February 2021

Development of pemphigus vulgaris during treatment with dipeptidyl peptidase-4 inhibitors: a case report.

Dermatol Ther 2021 May 15:e14982. Epub 2021 May 15.

Division of Dermatology, Mito Kyodo General Hospital, Ibaraki, Japan.

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Paraneoplastic pemphigus caused by pre-existing stroma-rich variant of Castleman disease: from a pathologist's point of view.

BMJ Case Rep 2021 May 11;14(5). Epub 2021 May 11.

Department of Cellular Pathology, North Bristol NHS Trust, Westbury on Trym, UK.

A young woman presented with mucocutaneous blisters and ulcerating lesions, and was diagnosed with erythrodermic pemphigus complicated by bronchiolitis obliterans. Her clinical condition did not improve on immunosuppressive therapy. She had a history of an asymptomatic retroperitoneal mass, presumed to be a dermoid cyst, followed up clinically. Read More

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Paraneoplastic pemphigus without mucosal lesions in a patient with ovarian cancer.

Int J Dermatol 2021 May 11. Epub 2021 May 11.

Center for Dermatology, Department of Pathology and Laboratory Medicine, Rutgers Robert Wood Johnson Medical School, Somerset, NJ, USA.

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Oroesophageal Pemphigus vulgaris Secondary to Lisinopril Use: A New Side Effect.

Cureus 2021 Apr 6;13(4):e14333. Epub 2021 Apr 6.

Gastroenterology, Allegheny Health Network, Pittsburgh, USA.

Pemphigoid diseases are a group of blistering autoimmune pathologies including pemphigus vulgaris (PV) and pemphigus foliaceous, which affect mucocutaneous tissues. Non-steroidal anti-inflammatory drugs, penicillamine, and angiotensin-converting enzyme inhibitors such as captopril and enalapril are associated with drug-induced pemphigoid. We present a case of lisinopril-associated PV which has not been previously reported. Read More

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MicroRNAs in pemphigus and pemphigoid diseases.

Autoimmun Rev 2021 Jul 7;20(7):102852. Epub 2021 May 7.

Department of Dermatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Autoimmune blistering diseases are a heterogenous group of dermatological disorders characterized by blisters and erosions of the skin and/or mucous membranes induced by autoantibodies against structural proteins of the desmosome or the dermal-epidermal adhesion complex including the hemidesmosome. They consist of the two major disease groups, pemphigus and pemphigoid diseases (PPDs). The diagnosis is based on clinical findings, histopathology, direct immunofluorescence, and detection of circulating autoantibodies. Read More

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