841 results match your criteria Pemphigus Erythematosus


Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases.

Front Med (Lausanne) 2022 9;9:875492. Epub 2022 Jun 9.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

An estimated 20-25% of the population is affected by chronic, non-communicable inflammatory skin diseases. Chronic skin inflammation has many causes. Among the most frequent chronic inflammatory skin diseases are atopic dermatitis, psoriasis, urticaria, lichen planus, and hidradenitis suppurativa, driven by a complex interplay of genetics and environmental factors. Read More

View Article and Full-Text PDF

Potential shared therapeutic and hepatotoxic mechanisms of Tripterygium wilfordii polyglycosides treating three kinds of autoimmune skin diseases by regulating IL-17 signaling pathway and Th17 cell differentiation.

J Ethnopharmacol 2022 Jun 21;296:115496. Epub 2022 Jun 21.

Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China. Electronic address:

Ethnopharmacological Relevance: Tripterygium wilfordii polyglycosides (TWP) are extracted from Tripterygium wilfordii Hook. f., which has the significant effects of anti-inflammation and immunosuppression and has been widely used to treat autoimmune diseases in traditional Chinese medicine. Read More

View Article and Full-Text PDF

Germinal Center-Related G Protein-Coupled Receptors in Antibody-Mediated Autoimmune Skin Diseases: from Basic Research to Clinical Trials.

Clin Rev Allergy Immunol 2022 Jun 8. Epub 2022 Jun 8.

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 12 Jiangwangmiao Street, Nanjing, 210042, China.

Germinal center (GC) reaction greatly contributes to the humoral immune response, which begins in lymph nodes or other secondary lymphoid organs after follicular B cells are activated by T-dependent antigens. The GCs then serve as a platform for follicular B cells to complete clonal expansion and somatic hypermutation and then interact with follicular dendritic cells (FDC) and follicular helper T cells (Tfh). Through the interaction between the immune cells, significant processes of the humoral immune response are accomplished, such as antibody affinity maturation, class switching, and production of memory B cells and plasma cells. Read More

View Article and Full-Text PDF

Bruton's Kinase Inhibitors for the Treatment of Immunological Diseases: Current Status and Perspectives.

J Clin Med 2022 May 16;11(10). Epub 2022 May 16.

Department of Hematology, Medical University of Lodz, 93-510 Lodz, Poland.

The use of Bruton's tyrosine kinase (BTK) inhibitors has changed the management of patients with B-cell lymphoid malignancies. BTK is an important molecule that interconnects B-cell antigen receptor (BCR) signaling. BTK inhibitors (BTKis) are classified into three categories, namely covalent irreversible inhibitors, covalent reversible inhibitors, and non-covalent reversible inhibitors. Read More

View Article and Full-Text PDF

The glucocorticoid toxicity index: Measuring change in glucocorticoid toxicity over time.

Semin Arthritis Rheum 2022 Apr 15;55:152010. Epub 2022 Apr 15.

Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.

Glucocorticoids (GCs) have been the cornerstone of treating dozens of inflammatory conditions for more than seven decades. GC toxicity is ubiquitous in both clinical trials and clinical practice, and toxicities associated with GC use are central to the experience of most patients being treated for immune-mediated conditions. These conditions span the full range of medical specialties, including rheumatology, nephrology, gastroenterology, neurology, pulmonology, ophthalmology, and others. Read More

View Article and Full-Text PDF

Sterile Neutrophilic Dermatosis (Sweet's Syndrome) Associated With Systemic Inflammatory Response Syndrome in a Maltese Dog: A Case Report.

Front Vet Sci 2022 21;9:837942. Epub 2022 Mar 21.

College of Veterinary Medicine, Gyeongsang National University, Jinju, South Korea.

We report a rare case of sterile neutrophilic dermatosis (Sweet's syndrome) accompanied by systemic inflammatory response syndrome. A 5-year-old, neutered male Maltese dog presented with extensive crusts on the whole-body surface and multifocal erosions and plaques on the four limbs. The lesions had been present for two months and did not respond to antibiotics before the presentation. Read More

View Article and Full-Text PDF

Angiotensin converting enzyme and angiotensin converting enzyme inhibitors in dermatology: a narrative review.

Expert Rev Clin Pharmacol 2022 Jan 2;15(1):33-42. Epub 2022 Mar 2.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Introduction: Angiotensin converting enzyme inhibitors (ACEI) are commonly used for cardiovascular diseases. The evidence supporting the use of ACEI in dermatology is limited.

Areas Covered: This review article was divided into three parts. Read More

View Article and Full-Text PDF
January 2022

Bruton's tyrosine kinase inhibition-An emerging therapeutic strategy in immune-mediated dermatological conditions.

Allergy 2022 Feb 17. Epub 2022 Feb 17.

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Bruton's tyrosine kinase (BTK), a member of the Tec kinase family, is critically involved in a range of immunological pathways. The clinical application of BTK inhibitors for B-cell malignancies has proven successful, and there is strong rationale for the potential benefits of BTK inhibitors in some autoimmune and allergic conditions, including immune-mediated dermatological diseases. However, the established risk-to-benefit profile of "first-generation" BTK inhibitors cannot be extrapolated to these emerging, non-oncological, indications. Read More

View Article and Full-Text PDF
February 2022

Off-label uses of TNF-a inhibitors and IL-12/23 inhibitors in dermatology.

Dermatol Online J 2021 Nov 15;27(11). Epub 2021 Nov 15.

University of California San Francisco, Department of Dermatology, Psoriasis and Skin Treatment Center.

TNF-a inhibitors, which include adalimumab, infliximab, etanercept, certolizumab, and golimumab, and IL-12/23 inhibitor, ustekinumab, have been widely used as a U.S. Food and Drug Administration (FDA) approved for the treatment of psoriasis. Read More

View Article and Full-Text PDF
November 2021

A Case of New-Onset Pemphigus Erythematosus after Topical Application of Ingenol Mebutate.

Indian J Dermatol 2021 Sep-Oct;66(5):563-565

Department of Dermatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. E-mail:

View Article and Full-Text PDF
January 2022

Dental implants in patients suffering from autoimmune diseases: A systematic critical review.

J Stomatol Oral Maxillofac Surg 2022 Jan 13. Epub 2022 Jan 13.

Division of Oral and Maxillofacial Surgery, Department of Surgery, University of Geneva and University Hospitals of Geneva, Geneva, Switzerland. Electronic address:

Purpose: This systematic review aimed to evaluate complications and survival rates of dental implants placed in patients suffering from autoimmune diseases.

Materials And Methods: A systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses systematic review guidelines (PRISMA), using Google scholar and PubMed electronic databases with a stop date of September 2021. The eligibility criteria included all full text human studies in the English language literature reporting on patients with autoimmune diseases treated with dental implants. Read More

View Article and Full-Text PDF
January 2022

Bruton's Tyrosine Kinase (BTK) Inhibitors and Autoimmune Diseases: Making Sense of BTK Inhibitor Specificity Profiles and Recent Clinical Trial Successes and Failures.

Front Immunol 2021 3;12:662223. Epub 2021 Nov 3.

Science Group, Clarivate, Philadelphia, PA, United States.

Clinical development of BTK kinase inhibitors for treating autoimmune diseases has lagged behind development of these drugs for treating cancers, due in part from concerns over the lack of selectivity and associated toxicity profiles of first generation drug candidates when used in the long term treatment of immune mediated diseases. Second generation BTK inhibitors have made great strides in limiting off-target activities for distantly related kinases, though they have had variable success at limiting cross-reactivity within the more closely related TEC family of kinases. We investigated the BTK specificity and toxicity profiles, drug properties, disease associated signaling pathways, clinical indications, and trial successes and failures for the 13 BTK inhibitor drug candidates tested in phase 2 or higher clinical trials representing 7 autoimmune and 2 inflammatory immune-mediated diseases. Read More

View Article and Full-Text PDF
January 2022

Assessment of Clinical and Laboratory Use of the Cutaneous Direct Immunofluorescence Assay.

JAMA Dermatol 2021 Nov;157(11):1343-1348

Massachusetts General Physician Organization Dermatopathology Associates, Newton, Massachusetts.

Importance: Dermatologists submit direct immunofluorescence (DIF) biopsies on a daily basis, using an assay detecting immunoreactant deposition with a panel that has traditionally comprised immunoglobulin (Ig) G, IgA, IgM, C3, and fibrin, with or without albumin antibodies.

Objectives: To evaluate and compare the frequency of immunoreactants in DIF biopsies submitted over an 8-year period and assess use by dermatologists based on clinical impression.

Design, Setting, And Participants: A quality improvement study was conducted in a community outreach reference laboratory associated with a large academic medical center. Read More

View Article and Full-Text PDF
November 2021

COVID-19 and exacerbation of dermatological diseases: A review of the available literature.

Dermatol Ther 2021 11 7;34(6):e15113. Epub 2021 Sep 7.

Network of Dermatology Research (NDR), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Since the emergence of the new coronavirus disease 19 (COVID-19) pandemic, there has been a concern for the patients with chronic autoimmune diseases including dermatological conditions over the potential exacerbation of these underlying conditions after infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV2). We performed a systematic review to evaluate presentations, postinfection change in the manifestation, diagnosis, and management of flare-ups of underlying dermatologic disease in patients with COVID-19. A total of 17 articles were recovered reporting on flare-ups of dermatological disease including pemphigus vulgaris, psoriasis, subacute cutaneous lupus erythematosus, acrodermatitis continua of Hallopeau, systemic sclerosis sine scleroderma, and Sézary syndrome (SS). Read More

View Article and Full-Text PDF
November 2021

Dysregulated translational factors and epigenetic regulations orchestrate in B cells contributing to autoimmune diseases.

Int Rev Immunol 2021 Aug 27:1-25. Epub 2021 Aug 27.

Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China.

B cells play a crucial role in antigen presentation, antibody production and pro-/anti-inflammatory cytokine secretion in adaptive immunity. Several translational factors including transcription factors and cytokines participate in the regulation of B cell development, with the cooperation of epigenetic regulations. Autoimmune diseases are generally characterized with autoreactive B cells and high-level pathogenic autoantibodies. Read More

View Article and Full-Text PDF

COVID-19 vaccine safety and efficacy in patients with immune-mediated inflammatory disease: Review of available evidence.

J Am Acad Dermatol 2021 Nov 4;85(5):1274-1284. Epub 2021 Aug 4.

Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address:

Dermatologists diagnose and treat many immune-mediated inflammatory diseases (IMID). Understanding the inherent immune dysregulation of these diseases as well as the additional disruption that comes as a result of IMID treatments has been important during the COVID-19 pandemic. With vaccines becoming widely available, dermatologists need to be familiar with the risks and benefits of vaccination in these patients, particularly those taking biologics, in order to have informed discussions with their patients. Read More

View Article and Full-Text PDF
November 2021

Isotopic response of labetalol-associated lichen planus pemphigoides on an old radiation site: A case report.

J Cutan Pathol 2021 Dec 30;48(12):1504-1507. Epub 2021 Jul 30.

Department of Dermatology, MacKay Memorial Hospital, Taipei, Taiwan.

Over the years, the occurrences of different types of skin disorders arising from radiation sites have been observed and studied. Examples include autoimmune blistering diseases such as pemphigus, pemphigoid, and interface or inflammatory reaction patterns such as lichen planus, lupus erythematosus, and Stevens-Johnson syndrome. The phenomenon whereby a new skin disorder arises from a previously healed or irradiated site is called an isotopic response, described as a type of Koebner phenomenon. Read More

View Article and Full-Text PDF
December 2021

Diagnostic Accuracy of Trichoscopy in Inflammatory Scalp Diseases: A Systematic Review.

Dermatology 2022 15;238(3):412-421. Epub 2021 Jul 15.

Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.

Background: The common inflammatory scalp diseases, such as psoriasis, seborrheic dermatitis, lichen planopilaris, discoid lupus erythematosus, contact dermatitis, or pemphigus may share similar clinical features.

Objective: To identify and systematically review the available evidence on the accuracy of trichoscopy in inflammatory scalp disorders.

Methods: A systematic review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Read More

View Article and Full-Text PDF

The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016.

PLoS One 2021 13;16(7):e0254634. Epub 2021 Jul 13.

Faculty of Dentistry, University of Khartoum, Khartoum, Khartoum State, Sudan.

Objectives: Autoimmune bullous diseases vary in their clinico-epidemiological features and burden across populations. Data about these diseases was lacking in Sudan. We aimed to describe the epidemiological profile and to estimate the burden of autoimmune bullous diseases in Sudan. Read More

View Article and Full-Text PDF
November 2021

Stem cell therapy in dermatology.

Indian J Dermatol Venereol Leprol 2021 Nov-Dec;87(6):753-767

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Stem cells are precursor cells present in many tissues with ability to differentiate into various types of cells. This interesting property of plasticity can have therapeutic implications and there has been substantial research in this field in last few decades. As a result, stem cell therapy is now used as a therapeutic modality in many conditions, and has made its way in dermatology too. Read More

View Article and Full-Text PDF
February 2022

Cutaneous manifestations related to the COVID-19 pandemic: a review article.

Cutan Ocul Toxicol 2021 Jun;40(2):168-174

Dermatology Department of Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Skin lesions are either caused by COVID-19 disease or they can be due to other driving forces related to the COVID-19 pandemic.

Aim: Considering the fact that the reported data in different articles for the type and prevalence of skin manifestations related to the COVID-19 pandemic are inconsistent, we have described the mechanism and type of skin lesions related to the COVID-19 pandemic.

Methods: In this review article, we have searched the Medline database (PubMed) for the combination of the following key terms "Dermatological Manifestation", "cutaneous Manifestation", "Skin Manifestation", "COVID-19", "SARS-CoV-2". Read More

View Article and Full-Text PDF

[The role Epstein-Barr virus played in the outcome of skin diseases].

Authors:
J W Lu Y Lu

Zhonghua Yi Xue Za Zhi 2021 Jun;101(20):1458-1462

Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Since the discovery of Epstein-Barr (EB) virus from the cultured cells in Burkitt lymphoma tissue in African children in 1964, we have gradually taken in its oncogenicity and the link between this virus and multiple mucocutaneous diseases. This review exhibits the process of EB virus infection and summarizes the clinical manifestations and varied prognosis of EB virus-associated skin diseases. The cases of common skin diseases including psoriasis, dermatomyositis, pemphigus, pemphigoid, parapsoriasis, atopic dermatitis, urticaria, systemic lupus erythematosus, scleroderma, panniculitis,erythema multiforme and vasculitis coinciding with EB virus infection were collected for the analysis of their EB virus-associated complications, treatments and outcomes. Read More

View Article and Full-Text PDF

Exploring the role of immunotherapeutic drugs in autoimmune diseases: A comprehensive review.

J Oral Biol Craniofac Res 2021 Apr-Jun;11(2):291-296. Epub 2021 Feb 23.

Department of Oral Medicine & Radiology, Government Dental College & Hospital, Nagpur, Maharashtra, India.

Autoimmune diseases are group of disorders where an immune response is mounted against the self. The prevalence and burden of this well established and recognised entity is on the rise. Irrespective of being a systemic or organ specific autoimmune disorder, the common underlying mechanism of action, is the imbalance in immune system resulting in loss of tolerance to self-antigens. Read More

View Article and Full-Text PDF
February 2021

Human cutaneous B cells: what do we really know?

Ann Transl Med 2021 Mar;9(5):440

Department of Dermatology, University of Rochester Medical Center, Rochester, NY, USA.

B cells play many critical roles in the systemic immune response, including antibody secretion, antigen presentation, T cell co-stimulation, and pro- and anti-inflammatory cytokine production. However, the contribution of B cells to the local immune response in many non-lymphoid tissues, such as the skin, is incompletely understood. Cutaneous B cells are scarce except in certain malignant and inflammatory conditions, and as such, have been poorly characterized until recently. Read More

View Article and Full-Text PDF

Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects.

Front Cell Dev Biol 2021 11;9:630942. Epub 2021 Mar 11.

Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden.

The cytoplasmic protein-tyrosine kinase BTK plays an essential role for differentiation and survival of B-lineage cells and, hence, represents a suitable drug target. The number of BTK inhibitors (BTKis) in the clinic has increased considerably and currently amounts to at least 22. First-in-class was ibrutinib, an irreversible binder forming a covalent bond to a cysteine in the catalytic region of the kinase, for which we have identified 228 active trials listed at ClinicalTrials. Read More

View Article and Full-Text PDF

Intraepithelial autoimmune blistering dermatoses: Clinical features and diagnosis.

J Am Acad Dermatol 2021 Jun 5;84(6):1507-1519. Epub 2021 Mar 5.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

Intraepithelial autoimmune blistering dermatoses are a rare group of skin disorders characterized by the intraepithelial disruption of intercellular connections through the action of autoantibodies. The first article in this continuing medical education series explores the background, epidemiology, clinical features, and diagnostic criteria of each of the major intraepithelial autoimmune blistering dermatoses, including pemphigus foliaceus, pemphigus erythematosus, pemphigus herpetiformis, fogo selvagem, pemphigus vulgaris, pemphigus vegetans, drug-induced pemphigus, IgA pemphigus, IgG/IgA pemphigus, and paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome. Read More

View Article and Full-Text PDF

Intraepithelial autoimmune bullous dermatoses disease activity assessment and therapy.

J Am Acad Dermatol 2021 Jun 5;84(6):1523-1537. Epub 2021 Mar 5.

Epiphany Dermatology, Dallas, Texas. Electronic address:

Intraepithelial autoimmune blistering dermatoses are a rare group of skin disorders characterized by disruptions of inter-keratinocyte connections within the epidermis through the action of autoantibodies. The second article in this continuing medical education series presents validated disease activity scoring systems, serologic parameters of disease, treatments, and clinical trials for pemphigus and its subtypes. Read More

View Article and Full-Text PDF

Association between pemphigus and systemic lupus erythematosus: a systematic review and meta-analysis.

An Bras Dermatol 2021 Mar-Apr;96(2):243-245. Epub 2021 Feb 1.

Department of Dermatology, The Dermatology & Skin Cancer Centre, Sydney, Australia.

View Article and Full-Text PDF

Pemphigus erythematosus: A case series from a tertiary academic center and literature review.

J Cutan Pathol 2021 Aug 9;48(8):1038-1050. Epub 2021 Mar 9.

Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

Background: Pemphigus erythematosus (PE) is a rare autoimmune skin condition with clinical, histopathological, and serological features that show overlap between lupus erythematosus and pemphigus foliaceus. It typically presents with erythematous, scaly plaques and has a female predominance.

Methods: After Institutional Review Board (IRB) approval, we searched the internal pathology database for "pemphigus erythematosus" in the diagnostic line between 1 January 2000 and 30 July 2020. Read More

View Article and Full-Text PDF

The prevalence of bipolar disorder in autoimmune disease: a systematic review and meta-analysis.

Ann Palliat Med 2021 Jan 11;10(1):350-361. Epub 2021 Jan 11.

Department of Geriatrics, Shanghai Pudong New District Mental Health Center, Shanghai, China.

Background: At the end of the last century, genome-wide association studies revealed a significant genetic association between bipolar disorder and autoimmune diseases. Subsequently, the theory of immune pathogenesis of bipolar disorder gradually formed, and the research on autoimmune diseases and bipolar comorbidities began to extend to other diseases, but their correlation is still controversial. To explore the differences in the prevalence of bipolar disorder in patients with autoimmune disease and normal healthy people through meta-analysis, and to examine the relationship between bipolar disorder and autoimmune disease by reviewing the relevant literature. Read More

View Article and Full-Text PDF
January 2021