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    Immunopathogenic Oral Diseases: 
An Overview Focusing on Pemphigus Vulgaris and Mucous Membrane Pemphigoid.
    Oral Health Prev Dent 2017 Mar 20. Epub 2017 Mar 20.
    Pemphigus vulgaris, mucosal pemphigoid (mucous membrane pemphigoid), lichen planus, discoid lupus erythematosus and erythema multiforme are a group of immune-mediated mucocutaneous disorders characterised clinically by the formation of blisters, erosions or ulcers. The oral mucosa is often affected, and sometimes the disease is limited to the mouth. The target antigens, autoreactive immune responses, microscopic features, treatment and prognosis vary from one disease to the other. Read More

    Pathogenic mechanisms of IgE-mediated inflammation in self-destructive autoimmune responses.
    Autoimmunity 2017 Feb;50(1):25-36
    a Department of Respiratory , Inflammation & Autoimmunity, MedImmune LLC , Gaithersburg , MD , USA.
    Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years. Despite their role in allergies, IgE autoantibodies are not associated with a higher rate of atopy in these patients. Read More

    Gonadectomy effects on the risk of immune disorders in the dog: a retrospective study.
    BMC Vet Res 2016 Dec 8;12(1):278. Epub 2016 Dec 8.
    Department of Animal Science, University of California, One Shields Ave, Davis, CA, 95616, USA.
    Background: Gonadectomy is one of the most common procedures performed on dogs in the United States. Neutering has been shown to reduce the risk for some diseases although recent reports suggest increased prevalence for structural disorders and some neoplasias. The relation between neuter status and autoimmune diseases has not been explored. Read More

    Autoimmune swallowing disorders.
    Curr Opin Otolaryngol Head Neck Surg 2016 Dec;24(6):483-488
    aMclaren Oakland Hospital, Pontiac bMichigan State University College of Osteopathic Medicine, East Lansing cMichigan State University, East Lansing dSt. John Macomb Hospital, Madison Heights eOakland University William Beaumont School of Medicine, Rochester fLakeshore Professional Voice Center, St. Clair Shores, Michigan, USA.
    Purpose Of Review: Dysphagia can be the presenting symptom of autoimmune disease. The otolaryngologist should be familiar with and consider these disorders when assessing the patient with swallowing difficulties.

    Recent Findings: The present review gives a brief overview of Sjogren's syndrome, granulomatosis with polyangiitis, pemphigus and pemphigoid, rheumatoid arthritis, systemic lupus erythematosus, scleroderma and inflammatory myopathies, and how they affect swallowing. Read More

    Significance of Anti-cyclic Citrullinated Peptide Autoantibodies in Immune-mediated Inflammatory Skin Disorders with and without Arthritis.
    Indian J Dermatol 2016 Sep-Oct;61(5):510-4
    Department of Microbiology, University College of Medical Sciences (UCMS) and GTB Hospital, New Delhi, India.
    Background: Anti-cyclic citrullinated peptides (CCPs) are autoantibodies directed against citrullinated peptides. Rheumatoid factor (RF), an antibody against the Fc portion of IgG, is known to form immune complexes and contribute to the etiopathogenesis of various skin disorders. C-reactive protein (CRP), an acute-phase protein, increases following secretion of interleukin-6 from macrophages and T cells. Read More

    A practical clinical recording system for cases with desquamative gingivitis.
    Br J Dermatol 2016 Sep 17. Epub 2016 Sep 17.
    WHO Collaborating Centre for Oral Health-General Health; and UCL, UK.
    The most frequent autoimmune disorders that involve the oral mucosae are lichen planus, pemphigoid, pemphigus, epidermolysis bullosa acquisita, erythema multiforme, discoid lupus erythematosus and chronic ulcerative stomatitis, affected individuals presenting with variable oral lesions; mainly(1-3) hyperkeratosis, erythema, blisters, erosions and ulcerations. The gingival tissues are commonly involved, not least because of decreases in oral hygiene(4) but the gingiva can be the unique site of onset or the first manifestation of the disorder(5) often as "desquamative gingivitis" (DG).(3,6,7)(This article is protected by copyright. Read More

    Effects of Miconazole Oral Gel on Blood Concentrations of Tacrolimus and Cyclosporine: A Retrospective Observational Study.
    Ther Drug Monit 2016 Dec;38(6):717-721
    *Department of Pharmacy, Medical Hospital, Tokyo Medical and Dental University (TMDU); Departments of †Rheumatology and ‡Pharmacokinetics and Pharmacodynamics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
    Background: Although azole antifungal agents have been shown to affect the pharmacokinetics of calcineurin inhibitors such as tacrolimus (TAC) and cyclosporine (CyA) by inhibiting drug metabolism, there are few clinical reports on drug interactions between miconazole (MCZ) oral gel and calcineurin inhibitors. In this study, the effects of MCZ oral gel on the blood concentrations of TAC and CyA were investigated.

    Methods: In this retrospective study, 18 patients concomitantly administered MCZ oral gel and TAC (9 for dermatomyositis, 3 for myasthenia gravis, 2 for systemic lupus erythematosus, 2 for rheumatoid arthritis, 1 for polymyositis, 1 for prevention of graft-versus-host disease after bone marrow transplantation), and 15 patients concomitantly administered MCZ oral gel and CyA (11 for interstitial pneumonia, 2 for pemphigus, 1 for eosinophilic granulomatosis with polyangiitis, 1 for systemic lupus erythematosus) were evaluated. Read More

    The incidence of herpes zoster in cutaneous lupus erythematosus (CLE), dermatomyositis (DM), pemphigus vulgaris (PV), and bullous pemphigoid (BP).
    J Am Acad Dermatol 2016 Jul;75(1):42-8
    Corporal Michael J. Crescenz Department of Veterans Affairs Medical Center, Philadelphia, Pennsylvania; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    Background: Herpes zoster is a common condition that causes significant morbidity.

    Objective: This study determined the incidence of zoster in patients with cutaneous lupus erythematosus (CLE), dermatomyositis (DM), pemphigus vulgaris (PV), and bullous pemphigoid (BP).

    Methods: In this retrospective cohort study the electronic medical records of 186 patients with CLE, 103 with DM, 83 with PV, 44 with BP, and 152 healthy control patients were reviewed to confirm positive diagnoses of zoster. Read More

    New Insights into the Management of Patients with Autoimmune Diseases or Inflammatory Disorders During Pregnancy.
    Scand J Immunol 2016 Sep;84(3):146-9
    Department of medical microbiology, school of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    The treatment of autoimmune diseases remains a serious problem. Current therapies can lead to adverse effects in patients. One of the most vulnerable patient groups is pregnant women. Read More

    Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy.
    Australas J Dermatol 2016 Jun 7. Epub 2016 Jun 7.
    Faculty of Life Sciences, Department of Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan.
    A 65-year-old woman had undergone a thymectomy for thymoma and 1 year after surgery she developed scattered erosive erythema with scaling and crusting. Examination findings exhibited the elevation of anti-dsDNA antibody, anti-desmoglein 1 antibody, anti-acetylcholine receptor antibody and anti-thyroglobulin antibody. A skin biopsy showed intraepidermal blisters containing neutrophils and acantholytic keratinocytes and direct immunofluorescence revealed the deposition of immunoglobulin G in the epidermis and on the basement membrane. Read More

    Skin diseases of the nose.
    Am J Rhinol Allergy 2016 May;30(3):83-90
    Otorhinolaryngology and Head and Neck Surgery Clinic, Bakirkoy Dr Sadi Konuk Research and Training Hospital, Istanbul, Turkey.
    Objectives: The goal of this study was to review the main lesion types of the nasal skin and appropriate treatment strategies rather than to present a comprehensive list of all diseases that affect the skin that can involve the nose.

    Methods: We reviewed the main nasal skin lesion types and available treatment strategies. Nasal skin lesions were classified as benign, premalignant, or malignant. Read More

    Utility of Direct Immunofluorescence Studies in Subclassification of Autoimmune Sub-Epidermal Bullous Diseases: A 2-Year Study in a Tertiary Care Hospital.
    Turk Patoloji Derg 2016 ;32(2):91-8
    Department of Pathology Bharati Vidyapeeth Deemed University Medical College and Hospital, SANGLI, INDIA.
    Objective: Sub-epidermal bullous disorders belong to immunobullous diseases which develop as a result of autoantibody action against epidermal basement membrane proteins. Clinically, they are tense bullae and do not rupture easily. They are classified into various forms based on histopathology and direct immunofluorescence patterns. Read More

    Periodic Acid-Schiff Staining Parallels the Immunoreactivity Seen By Direct Immunofluorescence in Autoimmune Skin Diseases.
    N Am J Med Sci 2016 Mar;8(3):151-5
    Department of Dermatopathology, Georgia Dermatopathology Associates, Atlanta, Georgia, USA.
    Background: In many countries and laboratories, techniques such as direct immunofluorescence (DIF) are not available for the diagnosis of skin diseases. Thus, these laboratories are limited in the full diagnoses of autoimmune skin diseases, vasculitis, and rheumatologic diseases. In our experience with these diseases and the patient's skin biopsies, we have noted a positive correlation between periodic acid-Schiff (PAS) staining and immunofluorescence patterns; however, these were just empiric observations. Read More

    Neonatal Autoimmune Blistering Disease: A Systematic Review.
    Pediatr Dermatol 2016 Jul 18;33(4):367-74. Epub 2016 Apr 18.
    Department of Dermatology, St. George Hospital, Sydney, New South Wales, Australia.
    We aimed to better understand the pathogenesis, clinical features, prognosis, and treatment of neonatal autoimmune blistering diseases (AIBDs). We searched Medline, Embase, PubMed, Latin American and Caribbean Health Sciences Literature, and reference lists of identified articles. Inclusion criteria were articles published from 1946 to December 2014 in any language. Read More

    Altered expression of keratin 14 in lesional epidermis of autoimmune skin diseases.
    Int J Dermatol 2016 Jun 6;55(6):620-8. Epub 2015 Nov 6.
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany.
    Background: Keratin 14 (K14) is an intermediate filament protein that is mainly expressed in the basal layer of healthy stratified epithelia. K14 has been identified as an autoantigen in the autoimmune-mediated skin disease of Scurfy mice and patients with the "immune dysregulation polyendocrinopathy, enteropathy, and X-linked" syndrome.

    Objectives: To examine whether K14 is a target protein in autoimmune skin diseases (ASD), we analyzed the expression pattern of K14 in lesional skin of patients with lichen ruber, cutaneous lupus erythematosus, dermatomyositis, graft-versus-host disease, psoriasis, and pemphigus vulgaris, and evaluated the reactivity of patient sera with recombinantly expressed and epidermis-derived K14. Read More

    Retrospective Study on Autoimmune Blistering Disease in Paediatric Patients.
    Pediatr Dermatol 2015 Nov-Dec;32(6):845-52. Epub 2015 Sep 22.
    Division of Dermatology, National University Hospital, Singapore, Singapore.
    Background: Autoimmune blistering diseases (AIBDs) are rare in children and their prevalence in Singapore is unclear. We aimed to investigate the clinical and immunopathologic characteristics of children diagnosed with AIBDs in Singapore.

    Materials And Methods: The clinical and histology databases at the National Skin Centre in Singapore were searched to identify patients younger than 18 years old diagnosed with an AIBD from January 1, 1998, through December 31, 2012. Read More

    Two cases of annular erythema without bullous lesions by autoimmune blistering diseases.
    Mod Rheumatol 2015 Oct 19:1-3. Epub 2015 Oct 19.
    a Department of Dermatology , Shiga University of Medical Science , Setatsukinowa , Otsu , Shiga , Japan.
    Although annular erythema is usually observed as one of the cutaneous manifestations of Sjögren's syndrome or subacute cutaneous lupus erythematosus, autoimmune blistering diseases also present with annular erythema. However, bullous lesions are not always found, and there is a rare type without bullous lesions. We present two cases of autoimmune blistering diseases showing annular erythema without bullous lesions. Read More

    Guanine polynucleotides are self-antigens for human natural autoantibodies and are significantly reduced in the human genome.
    Immunology 2015 Nov 7;146(3):401-10. Epub 2015 Sep 7.
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
    In the course of investigating anti-DNA autoantibodies, we examined IgM and IgG antibodies to poly-G and other oligonucleotides in the sera of healthy persons and those diagnosed with systemic lupus erythematosus (SLE), scleroderma (SSc), or pemphigus vulgaris (PV); we used an antigen microarray and informatic analysis. We now report that all of the 135 humans studied, irrespective of health or autoimmune disease, manifested relatively high amounts of IgG antibodies binding to the 20-mer G oligonucleotide (G20); no participants entirely lacked this reactivity. IgG antibodies to homo-nucleotides A20, C20 or T20 were present only in the sera of SLE patients who were positive for antibodies to dsDNA. Read More

    Evolutionary medicine and bone loss in chronic inflammatory diseases--A theory of inflammation-related osteopenia.
    Semin Arthritis Rheum 2015 Oct 30;45(2):220-8. Epub 2015 Apr 30.
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA.
    Objective: Bone loss is typical in chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, ankylosing spondylitis, systemic lupus erythematosus, multiple sclerosis, inflammatory bowel diseases, pemphigus vulgaris, and others. It is also typical in transplantation-related inflammation and during the process of aging. While we recognized that bone loss is tightly linked to immune system activation or inflamm-aging in the form of acute, chronic active, or chronic smoldering inflammation, bone loss is typically discussed to be an "accident of inflammation. Read More

    Allelic and copy-number variations of FcγRs affect granulocyte function and susceptibility for autoimmune blistering diseases.
    J Autoimmun 2015 Jul 29;61:36-44. Epub 2015 May 29.
    Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany. Electronic address:
    Low-affinity Fcγ receptors (FcγR) bridge innate and adaptive immune responses. In many autoimmune diseases, these receptors act as key mediators of the pathogenic effects of autoantibodies. Genes encoding FcγR exhibit frequent variations in sequence and gene copy number that influence their functional properties. Read More

    Role of direct immunofluorescence in dermatological disorders.
    Indian Dermatol Online J 2015 May-Jun;6(3):172-80
    Department of Dermatology, M. S. Ramaiah Medical College and Hospital, Bengaluru, Karnataka, India.
    Background: Direct immunofluorescence (DIF) test for tissue-bound autoantibodies, has been found to be of value in the diagnosis of several dermatological disorders. The location and pattern of deposition of immunoreactants helps in classifying various immune-mediated diseases.

    Aims And Objectives: The aim of this study was to analyze the concordance between the clinical, histopathological and DIF diagnosis in bullous and nonbullous lesions of the skin, and thus determine the impact of immunofluorescence on diagnosis. Read More

    Extracorporeal photopheresis for the treatment of autoimmune diseases.
    Transfus Apher Sci 2015 Apr 16;52(2):171-82. Epub 2015 Feb 16.
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
    The immune system is tasked with the unique challenge of recognizing foreign pathogens and damaged cells while at the same time preserving and protecting the integrity of "self". When this process fails, severe consequences including cancer and autoimmunity are the end result. Current therapies aimed at treating autoimmune disorders result in generalized immunosuppression and place the patient at increased risk for infection and malignancy. Read More

    Bullous systemic lupus erythematosus associated with esophagitis dissecans superficialis.
    Case Rep Rheumatol 2015 2;2015:930683. Epub 2015 Mar 2.
    Department of Medicine, Interfaith Medical Center, Brooklyn, NY 11213, USA.
    Bullous systemic lupus erythematosus is one of the rare autoantibody mediated skin manifestation of systemic lupus erythematosus (SLE) demonstrating subepidermal blistering with neutrophilic infiltrate histologically. We present a case of a 40-year-old Hispanic female who presented with a several months' history of multiple blistering pruritic skin lesions involving the face and trunk, a photosensitive rash over the face and neck, swelling of the right neck lymph node, and joint pain involving her elbows and wrist. Her malady was diagnosed as bullous systemic lupus erythematosus based on the immunological workup and biopsy of her skin lesions. Read More

    Pemphigus and associated comorbidities: a cross-sectional study.
    Clin Exp Dermatol 2015 Aug 18;40(6):593-9. Epub 2015 Mar 18.
    Division of Dermatology, ON, Canada.
    Background: Pemphigus is a rare autoimmune blistering disease, reported to be associated with other coexisting and autoimmune diseases, including thyroid diseases, rheumatoid arthritis, alopecia areata, vitiligo, systemic lupus erythematosus, scleroderma and rare entities such as myasthenia gravis.

    Aim: To identify and describe patients with pemphigus with a diagnosed comorbidity, and to quantify the risk of additional comorbidities.

    Methods: This was a cross-sectional study of patients with pemphigus treated at a tertiary referral centre. Read More

    [Cormorbidity in multiple sclerosis and its therapeutic approach].
    Med Clin (Barc) 2014 Dec;143 Suppl 3:13-8
    Unitat d'Esclerosi Múltiple, Hospital Universitari i Politècnic La Fe, València, España. Electronic address:
    Multiple sclerosis (MS) is a long-term chronic disease, in which intercurrent processes develop three times more frequently in affected individuals than in persons without MS. Knowledge of the comorbidity of MS, its definition and measurement (Charlson index) improves patient management. Acting on comorbid conditions delays the progression of disability, which is intimately linked to the number of concurrent processes and with health states and habits. Read More

    Complement system in dermatological diseases - fire under the skin.
    Front Med (Lausanne) 2015 29;2. Epub 2015 Jan 29.
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki , Helsinki , Finland ; Huslab, Helsinki University Central Hospital , Helsinki , Finland ; Research Programs Unit, Immunobiology, University of Helsinki , Helsinki , Finland.
    The complement system plays a key role in several dermatological diseases. Overactivation, deficiency, or abnormality of the control proteins are often related to a skin disease. Autoimmune mechanisms with autoantibodies and a cytotoxic effect of the complement membrane attack complex on epidermal or vascular cells can cause direct tissue damage and inflammation, e. Read More

    Dermatologic disorders in 118 patients with autoimmune (immunoglobulin G4-related) pancreatitis: a retrospective cohort analysis.
    Am J Clin Dermatol 2015 Apr;16(2):125-30
    Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
    Background: Autoimmune pancreatitis is the prototypical manifestation of immunoglobulin G4-related disease, a fibroinflammatory syndrome that can affect virtually any organ. Rarely, skin involvement has been reported in immunoglobulin G4-related disease. Isolated case reports have described other distinct associated dermatoses. Read More

    Immune-mediated diseases: what can be found in the oral cavity?
    Int J Dermatol 2015 Mar 16;54(3):258-70. Epub 2014 Dec 16.
    Department of Stomatology III, Faculty of Odontology, Complutense University of Madrid, Madrid, Spain.
    Immune-mediated diseases frequently affect oral mucosa, which may often be the first site of clinical manifestation. In this review, we describe the most important oral lesions related to inflammatory disorders and present their management and novel therapies. The review is based on an open PubMed literature search from 1980 to 2012 with relevant keywords. Read More

    B cell epitope spreading: mechanisms and contribution to autoimmune diseases.
    Immunol Lett 2015 Jan 20;163(1):56-68. Epub 2014 Nov 20.
    Brigham Young University, Department of Microbiology and Molecular Biology, Provo, UT 84602, United States. Electronic address:
    While a variety of factors act to trigger or initiate autoimmune diseases, the process of epitope spreading is an important contributor in their development. Epitope spreading is a diversification of the epitopes recognized by the immune system. This process happens to both T and B cells, with this review focusing on B cells. Read More

    Identification of a new disease cluster of pemphigus vulgaris with autoimmune thyroid disease, rheumatoid arthritis and type I diabetes.
    Br J Dermatol 2015 Mar 15;172(3):729-38. Epub 2015 Feb 15.
    Department of Dermatology, University at Buffalo, 875 Ellicott Street, 6082 Clinical and Translational Research Center, Buffalo, NY, U.S.A.
    Background: Pemphigus vulgaris (PV) is a potentially fatal autoimmune blistering skin disease. It is known that individuals with autoimmune diseases such as PV, as well as their family members, are at increased risk of developing other autoimmune diseases. However, it is unknown whether there are specific autoimmune diseases that cluster with PV. Read More

    Pemphigus erythematosus relapse associated with atorvastatin intake.
    Drug Des Devel Ther 2014 18;8:1463-5. Epub 2014 Sep 18.
    Department of Dermatology, AORN "A Cardarelli", Naples, Italy.
    Statins, also known as 3-hydroxy-3-methylglutaril-CoA reductase inhibitors, are well-tolerated drugs used for prevention of atherosclerosis and cardiovascular events. Although they are generally considered safe, some serious adverse effects, such as myositis, myopathy, and rhabdomyolysis can rarely occur. Furthermore, recent data from long-term follow-up on patients who have been taking statins for a long period of time suggest that prolonged exposure to statins may trigger autoimmune reactions. Read More

    Seborrheic pemphigoid.
    Case Rep Dermatol Med 2014 18;2014:768217. Epub 2014 Aug 18.
    Institute of Dermatology, Department of Experimental and Clinical Medicine, University of Udine, San Michele Hospital, Piazza Rodolone 1, Gemona del Friuli, 33013 Udine, Italy.
    Seborrheic pemphigoid (SP), first described in 1969 by Schnyder, is a peculiar variant of BP which clinically resembles pemphigus erythematosus, since it is characterized by ruptured bullae and erosions covered with crusts involving the seborrheic areas. To the best of our knowledge, from the first description only four other cases of SP have been reported, of which two are in the English literature. We report an additional case of SP in a 56-year-old man with cervical spondylogenic myelopathy with very impaired mobility. Read More

    A study on oral mucosal lesions in 3500 patients with dermatological diseases in South India.
    Ann Med Health Sci Res 2014 Jul;4(Suppl 2):S84-93
    Department of Oral and Maxillofacial Pathology and Microbiology, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
    Background: Oral mucosal lesions that are observed in the dermatological diseases are categorized under mucocutaneous conditions. The oral lesions in dermatological diseases may be the early aspects of the disease manifestation or the most significant clinical appearance or the only sign/and or symptom of such dermatological diseases and occasionally lesions occur simultaneously in the skin as well as mucous membrane.

    Aim: This present study attempts to find out the prevalence of oral mucosal lesions in patients with dermatological diseases. Read More

    Impaired quality of life in patients with systemic sclerosis compared to the general population and chronic dermatoses.
    BMC Res Notes 2014 Sep 2;7:594. Epub 2014 Sep 2.
    Department of Dermatology and Venereology, Medical University of Graz, Auenbrugger Platz 8, A-8036 Graz, Austria.
    Background: Systemic sclerosis (SSc) is a rare and potentially life threatening autoimmune disorder. The burden of disease compared to other dermatoses is unknown. The purpose of this study was to assess both the quality of life in patients with SSc and the variables that are associated with poor quality of life. Read More

    Severe drug-induced dermatoses.
    Semin Cutan Med Surg 2014 Mar;33(1):49-58
    Department of Dermatology, University of California San Francisco, CA USA. Email:
    A variety of common dermatoses are known to have drug-induced variants. This article discusses the clinical presentation, time frames, reported culprit medications, pathophysiology and management of drug-induced lupus, cutaneous vasculitis, pemphigus, pemphigoid, linear IgA bullous dermatosis, Sweet's syndrome, erythema nodosum, pyoderma gangrenosum, pseudolymphoma, lichen planus, and psoriasis. Read More

    Chronic desquamative gingivitis in siblings: A report of two cases.
    J Indian Soc Periodontol 2014 May;18(3):385-9
    Department of Conservative Dentistry, Terna Dental College, Navi Mumbai, Maharashtra, India.
    Desquamative gingivitis is a gingival response associated with a variety of clinical conditions and characterized by intense erythema, desquamation and ulceration of free and attached gingiva. A variety of diseases such as lichen planus, pemphigus, pemphigoid, dermatitis herpetiformis, linear IgA disease, lupus erythematosus, erythema multiformae manifest clinically as desquamative gingivitis. Of all the disease entities, Lichen Planus is a relatively common disorder affecting the skin and mucous membrane. Read More

    Two decades of using the combination of tetracycline derivatives and niacinamide as steroid-sparing agents in the management of pemphigus: defining a niche for these low toxicity agents.
    J Am Acad Dermatol 2014 Sep 4;71(3):475-9. Epub 2014 Jun 4.
    David Fivenson, MD, Dermatology PLLC, Ann Arbor, Michigan. Electronic address:
    Background: The twin goals of long-term disease control and minimizing toxicities related to immunosuppression necessitate efforts to find effective steroid-sparing agents in the management of patients with autoimmune bullous diseases. Pemphigus especially requires a long view, because the disease can persist throughout a patient's lifetime, yet few clinical trial reports exist to guide the practitioner.

    Objectives: We review the response of pemphigus patients to tetracycline, doxycycline, or minocycline plus niacinamide (TCN/NAM) as steroid-sparing therapy and to determine the effects of TCN/NAM on autoantibody levels during the long-term treatment of pemphigus. Read More

    Pemphigus vulgaris is characterized by low IgG reactivities to specific self-antigens along with high IgG reactivity to desmoglein 3.
    Immunology 2014 Nov;143(3):374-80
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel; Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot, Israel; Department of Nephrology, Rabin Medical Centre, Petach Tikva, Israel.
    Pemphigus vulgaris (PV) is an autoimmune skin disease, which has been characterized by IgG autoantibodies to desmoglein 3. Here we studied the antibody signatures of PV patients compared with healthy subjects and with patients with two other autoimmune diseases with skin manifestations (systemic lupus erythematosus and scleroderma), using an antigen microarray and informatics analysis. We now report a previously unobserved phenomenon--patients with PV, compared with the healthy subjects and the two other diseases, show a significant decrease in IgG autoantibodies to a specific set of self-antigens. Read More

    Autoimmune blistering dermatoses as systemic diseases.
    Clin Dermatol 2014 May-Jun;32(3):364-75. Epub 2013 Nov 22.
    Department of Dermatology and Venereology, Medical Faculty, Medical University-Sofia, 1 Georgi Sofiiski Boulevard, 1431 Sofia, Bulgaria.
    Autoimmune blistering dermatoses are examples of skin-specific autoimmune disorders that can sometimes represent the cutaneous manifestation of a multiorgan disease due to potential common pathogenic mechanisms. As soon as a distinct autoimmune blistering dermatosis is diagnosed, it is imperative to consider its potential systemic involvement, as well as the autoimmune and inflammatory conditions that are frequently associated with it. In paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome, the internal organs (particularly the lungs) are affected by the autoimmune injury. Read More

    [Cutaneous drug reactions imitating dermatoses].
    Hautarzt 2014 May;65(5):424-9
    Klinik für Hautkrankheiten, Universitätsklinikum Münster, Von-Esmarch-Str. 58, 48149, Münster, Deutschland,
    Background: Cutaneous adverse drug reactions are frequent and present with heterogenous clinical manifestations.

    Methods And Results: Increasingly, case reports describe drug reactions which mimic dermatoses, although exact data on prevalence are missing. Psoriasiform, lichenoid and pityriasiform exanthems are most frequent. Read More

    Bullous pemphigoid associated with acquired hemophilia a: a rare association of autoimmune disease.
    J Cutan Med Surg 2014 Mar-Apr;18(2):123-6
    Background: Acquired hemophilia (AH) is a rare autoimmune disease with an annual incidence of one per million and has a mortality rate of up to 22%. It is caused by the development of autoantibodies against factor VIII. Approximately half of the reported cases are associated with autoimmune disorders, pregnancy, malignancies, and adverse drug reactions. Read More

    Hair loss in autoimmune systemic diseases.
    G Ital Dermatol Venereol 2014 Feb;149(1):79-81
    DiSSal Section of Dermatology AOU San Martino‑IST Genoa, IRCCS University of Genoa, Genoa, Italy -
    Hair loss is commonly seen in autoimmune diseases. In pemphigus, although scalp involvement is common, hair loss is rarely reported. In classical bullous pemphigoid, alopecia is not reported while it is described in the Brusting-Perry variant of bullous pemphigoid and in epidermolysis bullosa acquisita. Read More

    Oral lichenoid tissue reactions: diagnosis and classification.
    Expert Rev Mol Diagn 2014 Mar 13;14(2):169-84. Epub 2014 Feb 13.
    Oral Medicine Department, Centre for Oral Health Research, Newcastle University, Framlington Place, NE2 4BW, Newcastle upon Tyne, UK.
    The concept of lichenoid tissue reaction/interface dermatitis was introduced in dermatology to define a number of diverse inflammatory skin diseases linked together by the presence of common histopathological features. Similarly to the skin, the oral mucosa is affected by a variety of oral lichenoid lesions. Oral LTRs (OLTRs) include: oral lichen planus; oral lichenoid contact lesion; oral lichenoid drug reaction; oral lichenoid lesions of graft-versus-host disease; oral discoid lupus erythematosus; oral lesions of systemic lupus erythematosus; erythema multiforme; paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome; chronic ulcerative stomatitis and lichen planus pemphigoid. Read More

    A review of the current literature and a guide to the early diagnosis of autoimmune disorders associated with neuromyelitis optica.
    Autoimmunity 2014 May 10;47(3):154-61. Epub 2014 Feb 10.
    The Walton Centre for Neurology and Neurosurgery , Liverpool , UK and.
    Neuromyelitis optica (NMO) is an immune-mediated neurological disorder characterised by recurrent episodes of optic neuritis and longitudinally extensive transverse myelitis. A serum biomarker, aquaporin-4 IgG, the autoantibody against aquaporin-4 water channel, has been specifically associated with NMO and has assisted early recognition and prediction of relapses. Less commonly, a monophasic course, associated with antibodies to myelin oligodendrocyte glycoprotein has been reported. Read More

    Three cases of vasospastic angina that developed following the initiation of corticosteroid therapy.
    Intern Med 2014 ;53(3):221-5
    Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, Japan.
    Three patients diagnosed as having remitting seronegative symmetrical synovitis with pitting edema syndrome, pemphigus erythematosus and idiopathic interstitial pneumonia were treated with oral prednisolone. Several weeks after starting the treatment, they experienced repeated chest pain attacks between midnight and early morning, although none of the patients had a past history of ischemic heart disease. One of the patients exhibited aggravation of symptoms soon after increasing the dose of prednisolone. Read More

    Immune-mediated dermatoses.
    Vet Clin North Am Equine Pract 2013 Dec;29(3):607-13
    Animal Dermatology Clinic, 2965 Edinger Avenue, Tustin, CA 92780, USA. Electronic address:
    Pemphigus foliaceus is the most common autoimmune skin disease in horses and is associated with the production of autoantibodies directed against surface proteins of the keratinocyte. Pemphigus vulgaris is a rare autoimmune skin disease in horses. Systemic lupus erythematosus and cutaneous lupus erythematosus are recognized in horses and both are rare. Read More

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