Peripheral CD19(hi) B cells exhibit activated phenotype and functionality in promoting IgG and IgM production in human autoimmune diseases.
Sci Rep 2017 Oct 24;7(1):13921. Epub 2017 Oct 24.
Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, P. R. China.
Systemic Lupus Erythematosus (SLE) and pemphigus are two representative autoimmune diseases driven by pathogenic autoantibody systemically and organ-specifically, respectively. Given the involvement of antibody in the pathogenesis, B cells are inclined to differentiate and function in an abnormal activation model. Here we defined a unique CD19(hi) B cell population existing in the periphery of SLE and pemphigus patients as well as in human tonsils. Read More