775 results match your criteria Pemphigus Erythematosus


The incidence of herpes zoster in cutaneous lupus erythematosus (CLE), dermatomyositis (DM), pemphigus vulgaris (PV), and bullous pemphigoid (BP).

Authors:
Eden Lake

J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Loyola Univ Medical Center Dermatology, 321 N La Grange Rd, La, Grange Park, IL. Electronic address:

The incidence of zoster is increased in many autoimmune diseases. This study found a significantly increased zoster incidence in dermatomyositis and cutaneous lupus erythematosus compared with a control group.Physicians should be aware of this risk and consider administering the vaccine against zoster to these patients if not contraindicated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183297
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http://dx.doi.org/10.1016/j.jaad.2018.10.077DOI Listing
December 2018
7 Reads

Systematic review of rituximab for autoimmune diseases: a potential alternative to intravenous immune globulin.

Transfusion 2018 Nov 23;58(11):2729-2735. Epub 2018 Sep 23.

Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

Background: The anti-CD20 monoclonal antibody rituximab has immune-modulatory effects similar to intravenous immunoglobulin (IVIG). We performed a systematic review and meta-analysis to determine the efficacy and safety of rituximab in autoimmune diseases that are also treated with IVIG.

Study Design And Methods: The most common indications for immune modulation with IVIG, as identified from a 2012 regional audit in Canada, were chronic inflammatory demyelinating polyneuropathy (CIDP), immune thrombocytopenia (ITP), myasthenia gravis, multifocal motor neuropathy, Guillain-Barré syndrome, systemic lupus erythematosus (SLE), Sjogren's syndrome, and pemphigus vulgaris. Read More

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http://dx.doi.org/10.1111/trf.14841DOI Listing
November 2018
3 Reads

Diagnosing Pemphigus Foliaceus: A Rare Blistering Disease Masquerading as a Common Dermatologic Disorder.

Mil Med 2018 Sep 12. Epub 2018 Sep 12.

Department of Dermatology, San Antonio Military Health System, 3551 Roger Brooke Drive, San Antonio, TX.

Pemphigus foliaceus (PF) is an autoimmune dermatologic disease that typically presents with painful, superficial blisters that evolve into scaling erosions in a seborrheic distribution. This case study intends to demonstrate that due to the relative scarcity of the disease and its distribution on the body, PF can easily be misdiagnosed. We present a 43-year-old African American male that presented to the dermatology clinic with an 18-month history of non-pruritic, violaceous, scaling patches and plaques most prominent on the malar cheeks, upper chest and upper back. Read More

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http://dx.doi.org/10.1093/milmed/usy224DOI Listing
September 2018

Autoimmune skin disease among dermatology outpatients in Botswana: a retrospective review.

Int J Dermatol 2019 Jan 31;58(1):50-53. Epub 2018 Aug 31.

Department of Dermatology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Background: There is a paucity of data describing autoimmune skin diseases in sub-Saharan Africa and in HIV positive cohorts. We describe the incidence of autoimmune skin diseases in public dermatology clinics in Botswana.

Methods: New patient records from public dermatology clinics were reviewed retrospectively for the period of September 2008 to December 2015. Read More

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http://dx.doi.org/10.1111/ijd.14201DOI Listing
January 2019
16 Reads
1.230 Impact Factor

Fogo selvagem: endemic pemphigus foliaceus.

An Bras Dermatol 2018 Sep-Oct;93(5):638-650

Dermatology Service, Hospital Maria Aparecida Pedrossian, Universidade Federal de Mato Grosso do Sul, Campo Grande (MS), Brazil.

Fogo selvagem or endemic pemphigus foliaceus is an autoimmune acantholytic anti-cadherin bullous disease that primarily affects seborrheic areas, which might disseminate. Brazil has the world's largest number of patients, mainly in the Central-West region, but the disease has also been reported in other South American countries. It affects young people and adults who have been exposed to rural areas, with occurrence of familial cases. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20188235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106655PMC
October 2018
10 Reads

Autoimmune Diseases and Their Manifestations on Oral Cavity: Diagnosis and Clinical Management.

J Immunol Res 2018 27;2018:6061825. Epub 2018 May 27.

Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Viale Regina Elena 287a, 00161 Rome, Italy.

Oral signs are frequently the first manifestation of autoimmune diseases. For this reason, dentists play an important role in the detection of emerging autoimmune pathologies. Indeed, an early diagnosis can play a decisive role in improving the quality of treatment strategies as well as quality of life. Read More

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https://www.hindawi.com/journals/jir/2018/6061825/
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http://dx.doi.org/10.1155/2018/6061825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994274PMC
October 2018
4 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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http://doi.wiley.com/10.1002/JPER.17-0719
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http://dx.doi.org/10.1002/JPER.17-0719DOI Listing
June 2018
27 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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http://dx.doi.org/10.1111/jcpe.12940DOI Listing
June 2018
46 Reads

New biochip immunofluorescence test for the serological diagnosis of pemphigus vulgaris and foliaceus: A review of the literature.

Int J Womens Dermatol 2018 Jun 3;4(2):102-108. Epub 2018 Feb 3.

Department of Dermatology, St George Hospital, Sydney, New South Wales, Australia.

The immunoassays that are available for the serological diagnosis of the more common subtypes of autoimmune blistering diseases such as pemphigus vulgaris (PV) and pemphigus foliaceus (PF) include enzyme-linked immunosorbent assay (ELISA) testing to specific antigens desmoglein (Dsg)1 and Dsg3, direct immunofluorescence (DIF), indirect immunofluorescence (IIF), and immunoblotting. A review of the literature on the biochip assay was conducted. Six studies investigated the validity of a new biochip, mosaic-based, IIF test in patients with pemphigus and demonstrated its relatively high sensitivity and specificity (Dsg3: 97. Read More

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http://dx.doi.org/10.1016/j.ijwd.2017.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986232PMC

A rare case with prominent features of both discoid lupus erythematosus and pemphigus foliaceus.

J Eur Acad Dermatol Venereol 2018 Jun 2. Epub 2018 Jun 2.

Department of Dermatology, Center for Blistering Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1111/jdv.15099DOI Listing
June 2018
1 Read

Intravenous immunoglobulins in dermatology. Part 2: clinical indications and outcomes.

Clin Exp Dermatol 2018 Aug 17;43(6):659-666. Epub 2018 May 17.

Dermatological Surgery and Laser Unit, St John's Institute of Dermatology, Guy's Hospital Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, UK.

Intravenous immunoglobulin (IVIg) is a solution of human IgG, salt, sugars and solvents used to treat a multitude of diseases. Although IVIg has been known to treat many diseases safely and successfully, there are relatively few supporting randomized controlled trials. In part two of this review, we assess the clinical indications of IVIg in dermatological disorders and the outcomes of its use. Read More

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http://dx.doi.org/10.1111/ced.13552DOI Listing

Unusually extensive scalp ulcerations manifested in pemphigus erythematosus.

Dermatol Online J 2018 Jan 15;24(1). Epub 2018 Jan 15.

University of Illinois College of Medicine, Chicago, Illinois.

Senear-Usher Syndrome, or pemphigus erythematosus, is an autoimmune skin blistering disorder with an overlapping clinical presentation of pemphigus foliaceus and lupus erythematosus. Lesions typically involve the scalp, face, and upper chest or back. This case study focuses on a patient who presentedwith progressive scalp ulcers, hyperpigmentation, and eroded plaques with overlying hemorrhagic crust. Read More

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January 2018
3 Reads

Gene Expression Analysis Reveals Novel Shared Gene Signatures and Candidate Molecular Mechanisms between Pemphigus and Systemic Lupus Erythematosus in CD4 T Cells.

Front Immunol 2017 17;8:1992. Epub 2018 Jan 17.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

Pemphigus and systemic lupus erythematosus (SLE) are severe potentially life-threatening autoimmune diseases. They are classified as B-cell-mediated autoimmune diseases, both depending on autoreactive CD4 T lymphocytes to modulate the autoimmune B-cell response. Despite the reported association of pemphigus and SLE, the molecular mechanisms underlying their comorbidity remain unknown. Read More

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http://dx.doi.org/10.3389/fimmu.2017.01992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776326PMC
January 2018
5 Reads

High-dose intravenous immunoglobulins for the treatment of dermatological autoimmune diseases.

J Dtsch Dermatol Ges 2017 Dec;15(12):1211-1226

Department of Dermatology, University of Heidelberg, Heidelberg, Germany.

Based on their immunomodulatory properties, high-dose intravenous immunoglobulins (IVIGs) are successfully used in the treatment of various dermatological autoimmune diseases, in particular pemphigus vulgaris and dermatomyositis. In autoimmune bullous diseases, IVIGs can be used in an adjuvant setting (second- or third-line therapy) once combined immunosuppressive regimens have failed. In dermatomyositis, IVIGs may already be employed as an adjuvant second-line therapy after failure of corticosteroid monotherapy. Read More

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http://dx.doi.org/10.1111/ddg.13389DOI Listing
December 2017
17 Reads

Oral Manifestation in Patients diagnosed with Dermatological Diseases.

J Contemp Dent Pract 2017 Dec 1;18(12):1153-1158. Epub 2017 Dec 1.

Department of Oral Pathology and Microbiology, M. A. Rangoonwala College of Dental Sciences & Research Centre Pune, Maharashtra, India.

Aim: This study aimed to estimate the frequency of oral lesions in dermatological diseased patients attending the outpatient department of Pravara Rural Medical and Dental College and Hospital, Pravara Institute of Medical Sciences (Deemed University), Loni, Ahmednagar, Maharashtra, India, and the Department of Dermatology at Medical College, Ahmednagar, Maharashtra, India.

Materials And Methods: A cross-sectional hospital-based study was conducted in Loni from October 2013 to January 2014. A total of 310 patients (mean age 37. Read More

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December 2017
5 Reads

Peripheral CD19 B cells exhibit activated phenotype and functionality in promoting IgG and IgM production in human autoimmune diseases.

Sci Rep 2017 Oct 24;7(1):13921. Epub 2017 Oct 24.

Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, P. R. China.

Systemic Lupus Erythematosus (SLE) and pemphigus are two representative autoimmune diseases driven by pathogenic autoantibody systemically and organ-specifically, respectively. Given the involvement of antibody in the pathogenesis, B cells are inclined to differentiate and function in an abnormal activation model. Here we defined a unique CD19 B cell population existing in the periphery of SLE and pemphigus patients as well as in human tonsils. Read More

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http://dx.doi.org/10.1038/s41598-017-14089-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655037PMC
October 2017
7 Reads

Human papillomavirus vaccination of adult women and risk of autoimmune and neurological diseases.

J Intern Med 2018 Feb 18;283(2):154-165. Epub 2017 Oct 18.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Background: Since 2006, human papillomavirus (HPV) vaccines have been introduced in many countries worldwide. Whilst safety studies have been reassuring, focus has been on the primary target group, the young adolescent girls. However, it is also important to evaluate safety in adult women where background disease rates and safety issues could differ significantly. Read More

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http://dx.doi.org/10.1111/joim.12694DOI Listing
February 2018
4 Reads

Spectrum of orocutaneous disease associations: Immune-mediated conditions.

J Am Acad Dermatol 2017 Nov;77(5):795-806

Division of Dermatology, Baylor University Medical Center, Dallas, Texas. Electronic address:

There are a number of diseases that manifest both on the skin and the oral mucosa, and therefore the importance for dermatologists in clinical practice to be aware of these associations is paramount. In the following continuing medical education series, we outline orocutaneous disease associations with both immunologic and inflammatory etiologies. Read More

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http://dx.doi.org/10.1016/j.jaad.2017.02.019DOI Listing
November 2017
12 Reads

Evaluation of Anti-Cyclic Citrullinated Peptide Autoantibodies and C-Reactive Protein in Common Autoimmune Skin Diseases with and without Arthritis.

J Clin Diagn Res 2017 Jul 1;11(7):BC06-BC08. Epub 2017 Jul 1.

Professor and Hod, Department of Skin and VD, Patna Medical College and Hospital, Patna, Bihar, India.

Introduction: Anti-Cyclic Citrullinated Peptides (CCPs) are a well known diagnostic and prognostic noble marker for rheumatoid arthritis. C-Reactive Protein (CRP) is an acute phase protein whose level rises in response to inflammation.

Aim: This study was undertaken to show the role of the two markers (anti-CCPs and CRP) in autoimmune skin disorder and their association with associated arthritis in these disorder. Read More

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http://dx.doi.org/10.7860/JCDR/2017/27234.10176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583789PMC
July 2017
11 Reads

Survey of False-positive Reactivity of Latex Agglutination Test for Kala-azar (Katex) without Urine Sample Boiling Process in Autoimmune Patients.

Iran J Public Health 2017 Jun;46(6):804-810

Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Background: Latex agglutination test for Kala-azar (KAtex) is an easy, inexpensive, and field-applicable antigen detection test. However, the main drawback of this method is the boiling step applied to remove false positivity of the test. This study was conducted to survey false positivity results of latex agglutination test for KAtex without boiling process in urine of some autoimmune patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558074PMC
June 2017
7 Reads

The Value of Direct Immunofluorescence on Proteinase-Digested Formalin-Fixed Paraffin-Embedded Skin Biopsies.

Am J Dermatopathol 2018 Feb;40(2):111-117

Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA.

Direct immunofluorescence (DIF) on frozen tissue (DIF-F) is the method of choice for the identification of immune deposits present in skin and other tissues. DIF can also be performed on formalin-fixed paraffin-embedded tissue (DIF-P) after antigen retrieval with proteases and has proven to be of value in renal pathology. However, its utility in skin biopsies has not been fully examined. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000934DOI Listing
February 2018
18 Reads

Comorbid autoimmune diseases in patients with pemphigus: a nationwide case-control study in Taiwan.

Eur J Dermatol 2017 Aug;27(4):375-381

Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Dermatology, National Yang-Ming University, Taipei, Taiwan.

Previous studies have proposed the association between pemphigus and several autoimmune diseases, but no large-scale study has been reported. To delineate the association between pemphigus and autoimmune diseases including psoriasis. A total of 1,998 patients with pemphigus and 7,992 control subjects were enrolled from the National Health Insurance Research Database in Taiwan from 1997 to 2010. Read More

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http://dx.doi.org/10.1684/ejd.2017.3060DOI Listing
August 2017
2 Reads

Generalized Discoid Lupus Erythematosus as the Presenting Sign of Small Cell Lung Carcinoma.

Skinmed 2017 1;15(3):218-220. Epub 2017 Jun 1.

Department of Dermatology, Mayo Clinic, Rochester, MN.

A 46-year-old woman with a 30 pack-year smoking history presented with a worsening eruption on the left cheek that failed to improve with metronidazole gel. The cutaneous eruption spread to most of her face and did not respond to a brief tapering course of prednisone. During the initial evaluation at our institution, approximately 6 weeks after the onset of the cutaneous eruption, the patient had erythematous, crusted plaques on her face and scalp (Figure 1A); they were also present on the V-area of the anterior aspect of the neck and upper region of the chest, the shoulders, and the arms, with isolated lesions on the trunk and legs. Read More

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June 2017
9 Reads

Robust memory responses against influenza vaccination in pemphigus patients previously treated with rituximab.

JCI Insight 2017 Jun 15;2(12). Epub 2017 Jun 15.

Department of Pediatrics, Division of Infectious Disease.

Rituximab is a therapeutic anti-CD20 monoclonal antibody widely used to treat B cell lymphoma and autoimmune diseases, such as rheumatic arthritis, systemic lupus erythematosus, and autoimmune blistering skin diseases (AIBD). While rituximab fully depletes peripheral blood B cells, it remains unclear whether some preexisting B cell memory to pathogens or vaccines may survive depletion, especially in lymphoid tissues, and if these memory B cells can undergo homeostatic expansion during recovery from depletion. The limited data available on vaccine efficacy in this setting have been derived from rituximab-treated patients receiving concomitant chemotherapy or other potent immunosuppressants. Read More

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https://insight.jci.org/articles/view/93222
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http://dx.doi.org/10.1172/jci.insight.93222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470882PMC
June 2017
17 Reads

[Safety and efficacy of off-label use of biologic therapies in patients with inflammatory rheumatic diseases refractory to standard of care therapy : Data from a nationwide German registry (GRAID2)].

Z Rheumatol 2018 Feb;77(1):28-39

Medizinische Klinik m.S. Rheumatologie und Klinische Immunologie, Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Deutschland.

Background: The German Registry of Autoimmune Diseases 2 (GRAID2) is a retrospective, non-interventional, multicenter registry study collecting data from patients with inflammatory, mainly rheumatic diseases refractory to standard of care therapy and treated with an off-label biologic therapy. The retrospective documentation comprised case history, diagnosis, course of disease (including safety and global efficacy). The objective was to evaluate the global clinical outcome and safety of off-label biologic therapy in clinical practice. Read More

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http://dx.doi.org/10.1007/s00393-017-0330-4DOI Listing
February 2018
4 Reads

Evaluation of prolactin levels in patients with newly diagnosed pemphigus vulgaris and its correlation with pemphigus disease area index.

Int J Womens Dermatol 2016 Jun 23;2(2):53-55. Epub 2016 Apr 23.

Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.

Background: Prolactin is a hormone; in addition to it known roles, it has immunomodulatory effects on lymphocytes maturation and immunoglobulins production. Hyperprolactinemia has been demonstrated in various autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, type I diabetes mellitus, and Graves' disease. In view of the prolactin immunomodulatory roles, studying prolactin levels in pemphigus as an autoimmune blistering disease may introduce new ways of understanding disease etiology and developing treatment strategies. Read More

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http://dx.doi.org/10.1016/j.ijwd.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412104PMC
June 2016
23 Reads

A study of clinical, histopathological and direct immunofluorescence diagnosis in pemphigus group Utility of direct immunofluorescence.

Bratisl Lek Listy 2017 ;118(4):243-249

Aims: To determine the diagnostic accordance between histopathological and direct immunofluorescence diagnosis of patients with autoimmune vesiculobullous skin diseases.

Background: The term pemphigus refers to a group of autoimmune blistering diseases mediated by auto-antibodies directed against desmoglein proteins. The differentiation between the various bullous diseases is important for treatment and prognosis. Read More

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http://www.elis.sk/index.php?page=shop.product_details&f
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http://dx.doi.org/10.4149/BLL_2017_048DOI Listing
August 2017
9 Reads

[Thymoma and autoimmune diseases].

Rev Med Interne 2018 Jan 30;39(1):17-26. Epub 2017 Mar 30.

Service de médecine interne, hospices civils de Lyon, hôpital de la Croix-Rousse, université Claude-Bernard - Lyon 1, 103, grande rue de la Croix-Rousse, 69004 Lyon, France.

The association between thymoma and autoimmunity is well known. Besides myasthenia gravis, which is found in 15 to 20% of patients with thymoma, other autoimmune diseases have been reported: erythroblastopenia, systemic lupus erythematosus, inflammatory myopathies, thyroid disorders, Isaac's syndrome or Good's syndrome. More anecdotally, Morvan's syndrome, limbic encephalitis, other autoimmune cytopenias, autoimmune hepatitis, and bullous skin diseases (pemphigus, lichen) have been reported. Read More

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http://dx.doi.org/10.1016/j.revmed.2017.03.003DOI Listing
January 2018
1 Read

Immunopathogenic Oral Diseases: An Overview 
Focusing on Pemphigus Vulgaris and Mucous Membrane Pemphigoid.

Oral Health Prev Dent 2017;15(2):177-182

Pemphigus vulgaris, mucosal pemphigoid (mucous membrane pemphigoid), lichen planus, discoid lupus erythematosus and erythema multiforme are a group of immune-mediated mucocutaneous disorders characterised clinically by the formation of blisters, erosions or ulcers. The oral mucosa is often affected, and sometimes the disease is limited to the mouth. The target antigens, autoreactive immune responses, microscopic features, treatment and prognosis vary from one disease to the other. Read More

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http://dx.doi.org/10.3290/j.ohpd.a37930DOI Listing
November 2017
12 Reads

Pathogenic mechanisms of IgE-mediated inflammation in self-destructive autoimmune responses.

Autoimmunity 2017 Feb;50(1):25-36

a Department of Respiratory , Inflammation & Autoimmunity, MedImmune LLC , Gaithersburg , MD , USA.

Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years. Despite their role in allergies, IgE autoantibodies are not associated with a higher rate of atopy in these patients. Read More

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http://dx.doi.org/10.1080/08916934.2017.1280670DOI Listing
February 2017
18 Reads

Gonadectomy effects on the risk of immune disorders in the dog: a retrospective study.

BMC Vet Res 2016 Dec 8;12(1):278. Epub 2016 Dec 8.

Department of Animal Science, University of California, One Shields Ave, Davis, CA, 95616, USA.

Background: Gonadectomy is one of the most common procedures performed on dogs in the United States. Neutering has been shown to reduce the risk for some diseases although recent reports suggest increased prevalence for structural disorders and some neoplasias. The relation between neuter status and autoimmune diseases has not been explored. Read More

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http://dx.doi.org/10.1186/s12917-016-0911-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146839PMC
December 2016
6 Reads

Autoimmune swallowing disorders.

Curr Opin Otolaryngol Head Neck Surg 2016 Dec;24(6):483-488

aMclaren Oakland Hospital, Pontiac bMichigan State University College of Osteopathic Medicine, East Lansing cMichigan State University, East Lansing dSt. John Macomb Hospital, Madison Heights eOakland University William Beaumont School of Medicine, Rochester fLakeshore Professional Voice Center, St. Clair Shores, Michigan, USA.

Purpose Of Review: Dysphagia can be the presenting symptom of autoimmune disease. The otolaryngologist should be familiar with and consider these disorders when assessing the patient with swallowing difficulties.

Recent Findings: The present review gives a brief overview of Sjogren's syndrome, granulomatosis with polyangiitis, pemphigus and pemphigoid, rheumatoid arthritis, systemic lupus erythematosus, scleroderma and inflammatory myopathies, and how they affect swallowing. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000312DOI Listing
December 2016
6 Reads

Significance of Anti-cyclic Citrullinated Peptide Autoantibodies in Immune-mediated Inflammatory Skin Disorders with and without Arthritis.

Indian J Dermatol 2016 Sep-Oct;61(5):510-4

Department of Microbiology, University College of Medical Sciences (UCMS) and GTB Hospital, New Delhi, India.

Background: Anti-cyclic citrullinated peptides (CCPs) are autoantibodies directed against citrullinated peptides. Rheumatoid factor (RF), an antibody against the Fc portion of IgG, is known to form immune complexes and contribute to the etiopathogenesis of various skin disorders. C-reactive protein (CRP), an acute-phase protein, increases following secretion of interleukin-6 from macrophages and T cells. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029235PMC
http://dx.doi.org/10.4103/0019-5154.190122DOI Listing
October 2016
11 Reads

Effects of Miconazole Oral Gel on Blood Concentrations of Tacrolimus and Cyclosporine: A Retrospective Observational Study.

Ther Drug Monit 2016 12;38(6):717-721

*Department of Pharmacy, Medical Hospital, Tokyo Medical and Dental University (TMDU); Departments of †Rheumatology and ‡Pharmacokinetics and Pharmacodynamics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

Background: Although azole antifungal agents have been shown to affect the pharmacokinetics of calcineurin inhibitors such as tacrolimus (TAC) and cyclosporine (CyA) by inhibiting drug metabolism, there are few clinical reports on drug interactions between miconazole (MCZ) oral gel and calcineurin inhibitors. In this study, the effects of MCZ oral gel on the blood concentrations of TAC and CyA were investigated.

Methods: In this retrospective study, 18 patients concomitantly administered MCZ oral gel and TAC (9 for dermatomyositis, 3 for myasthenia gravis, 2 for systemic lupus erythematosus, 2 for rheumatoid arthritis, 1 for polymyositis, 1 for prevention of graft-versus-host disease after bone marrow transplantation), and 15 patients concomitantly administered MCZ oral gel and CyA (11 for interstitial pneumonia, 2 for pemphigus, 1 for eosinophilic granulomatosis with polyangiitis, 1 for systemic lupus erythematosus) were evaluated. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000335DOI Listing
December 2016
36 Reads

The incidence of herpes zoster in cutaneous lupus erythematosus (CLE), dermatomyositis (DM), pemphigus vulgaris (PV), and bullous pemphigoid (BP).

J Am Acad Dermatol 2016 Jul;75(1):42-8

Corporal Michael J. Crescenz Department of Veterans Affairs Medical Center, Philadelphia, Pennsylvania; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Background: Herpes zoster is a common condition that causes significant morbidity.

Objective: This study determined the incidence of zoster in patients with cutaneous lupus erythematosus (CLE), dermatomyositis (DM), pemphigus vulgaris (PV), and bullous pemphigoid (BP).

Methods: In this retrospective cohort study the electronic medical records of 186 patients with CLE, 103 with DM, 83 with PV, 44 with BP, and 152 healthy control patients were reviewed to confirm positive diagnoses of zoster. Read More

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http://dx.doi.org/10.1016/j.jaad.2016.02.1153DOI Listing
July 2016
13 Reads

New Insights into the Management of Patients with Autoimmune Diseases or Inflammatory Disorders During Pregnancy.

Scand J Immunol 2016 Sep;84(3):146-9

Department of medical microbiology, school of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The treatment of autoimmune diseases remains a serious problem. Current therapies can lead to adverse effects in patients. One of the most vulnerable patient groups is pregnant women. Read More

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http://doi.wiley.com/10.1111/sji.12453
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http://dx.doi.org/10.1111/sji.12453DOI Listing
September 2016
5 Reads

Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy.

Australas J Dermatol 2017 Aug 7;58(3):e120-e122. Epub 2016 Jun 7.

Faculty of Life Sciences, Department of Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan.

A 65-year-old woman had undergone a thymectomy for thymoma and 1 year after surgery she developed scattered erosive erythema with scaling and crusting. Examination findings exhibited the elevation of anti-dsDNA antibody, anti-desmoglein 1 antibody, anti-acetylcholine receptor antibody and anti-thyroglobulin antibody. A skin biopsy showed intraepidermal blisters containing neutrophils and acantholytic keratinocytes and direct immunofluorescence revealed the deposition of immunoglobulin G in the epidermis and on the basement membrane. Read More

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http://dx.doi.org/10.1111/ajd.12510DOI Listing
August 2017
26 Reads

Management of rheumatic and autoimmune blistering disease in pregnancy and postpartum.

Clin Dermatol 2016 May-Jun;34(3):344-52. Epub 2016 Feb 9.

Department of Dermatology, Perelman School of Medicine, Philadelphia, Pennsylvania; Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania. Electronic address:

The treatment of rheumatic and autoimmune skin disease in women who are pregnant or of childbearing potential can present challenges to the dermatologist. We discuss the current approaches to treating lupus erythematosus, antiphospholipid antibody syndrome, dermatomyositis, morphea and systemic sclerosis, mixed connective tissue disease, rheumatoid arthritis, and autoimmune blistering disease in such patients. In the appropriate setting, topical and systemic corticosteroids, hydroxychloroquine, dapsone, azathioprine, and ultraviolet B phototherapy may be safely and cautiously used during pregnancy. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2016.02.006DOI Listing
May 2017
4 Reads

Skin diseases of the nose.

Am J Rhinol Allergy 2016 May;30(3):83-90

Otorhinolaryngology and Head and Neck Surgery Clinic, Bakirkoy Dr Sadi Konuk Research and Training Hospital, Istanbul, Turkey.

Objectives: The goal of this study was to review the main lesion types of the nasal skin and appropriate treatment strategies rather than to present a comprehensive list of all diseases that affect the skin that can involve the nose.

Methods: We reviewed the main nasal skin lesion types and available treatment strategies. Nasal skin lesions were classified as benign, premalignant, or malignant. Read More

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http://dx.doi.org/10.2500/ajra.2016.30.4318DOI Listing
May 2016
9 Reads

Utility of Direct Immunofluorescence Studies in Subclassification of Autoimmune Sub-Epidermal Bullous Diseases: A 2-Year Study in a Tertiary Care Hospital.

Turk Patoloji Derg 2016 ;32(2):91-8

Department of Pathology Bharati Vidyapeeth Deemed University Medical College and Hospital, SANGLI, INDIA.

Objective: Sub-epidermal bullous disorders belong to immunobullous diseases which develop as a result of autoantibody action against epidermal basement membrane proteins. Clinically, they are tense bullae and do not rupture easily. They are classified into various forms based on histopathology and direct immunofluorescence patterns. Read More

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http://dx.doi.org/10.5146/tjpath.2015.01345DOI Listing
April 2017
10 Reads

Periodic Acid-Schiff Staining Parallels the Immunoreactivity Seen By Direct Immunofluorescence in Autoimmune Skin Diseases.

N Am J Med Sci 2016 Mar;8(3):151-5

Department of Dermatopathology, Georgia Dermatopathology Associates, Atlanta, Georgia, USA.

Background: In many countries and laboratories, techniques such as direct immunofluorescence (DIF) are not available for the diagnosis of skin diseases. Thus, these laboratories are limited in the full diagnoses of autoimmune skin diseases, vasculitis, and rheumatologic diseases. In our experience with these diseases and the patient's skin biopsies, we have noted a positive correlation between periodic acid-Schiff (PAS) staining and immunofluorescence patterns; however, these were just empiric observations. Read More

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http://dx.doi.org/10.4103/1947-2714.179132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821094PMC
March 2016
12 Reads

Circulating Transglutaminase 3-Immunoglobulin A Immune Complexes in Dermatitis Herpetiformis.

J Invest Dermatol 2016 08 20;136(8):1729-1731. Epub 2016 Apr 20.

Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.03.039DOI Listing
August 2016
3 Reads

Neonatal Autoimmune Blistering Disease: A Systematic Review.

Pediatr Dermatol 2016 Jul 18;33(4):367-74. Epub 2016 Apr 18.

Department of Dermatology, St. George Hospital, Sydney, New South Wales, Australia.

We aimed to better understand the pathogenesis, clinical features, prognosis, and treatment of neonatal autoimmune blistering diseases (AIBDs). We searched Medline, Embase, PubMed, Latin American and Caribbean Health Sciences Literature, and reference lists of identified articles. Inclusion criteria were articles published from 1946 to December 2014 in any language. Read More

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http://dx.doi.org/10.1111/pde.12859DOI Listing
July 2016
11 Reads

Altered expression of keratin 14 in lesional epidermis of autoimmune skin diseases.

Int J Dermatol 2016 Jun 6;55(6):620-8. Epub 2015 Nov 6.

Department of Dermatology, University of Heidelberg, Heidelberg, Germany.

Background: Keratin 14 (K14) is an intermediate filament protein that is mainly expressed in the basal layer of healthy stratified epithelia. K14 has been identified as an autoantigen in the autoimmune-mediated skin disease of Scurfy mice and patients with the "immune dysregulation polyendocrinopathy, enteropathy, and X-linked" syndrome.

Objectives: To examine whether K14 is a target protein in autoimmune skin diseases (ASD), we analyzed the expression pattern of K14 in lesional skin of patients with lichen ruber, cutaneous lupus erythematosus, dermatomyositis, graft-versus-host disease, psoriasis, and pemphigus vulgaris, and evaluated the reactivity of patient sera with recombinantly expressed and epidermis-derived K14. Read More

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http://dx.doi.org/10.1111/ijd.13011DOI Listing
June 2016
8 Reads

Retrospective Study on Autoimmune Blistering Disease in Paediatric Patients.

Pediatr Dermatol 2015 Nov-Dec;32(6):845-52. Epub 2015 Sep 22.

Division of Dermatology, National University Hospital, Singapore, Singapore.

Background: Autoimmune blistering diseases (AIBDs) are rare in children and their prevalence in Singapore is unclear. We aimed to investigate the clinical and immunopathologic characteristics of children diagnosed with AIBDs in Singapore.

Materials And Methods: The clinical and histology databases at the National Skin Centre in Singapore were searched to identify patients younger than 18 years old diagnosed with an AIBD from January 1, 1998, through December 31, 2012. Read More

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http://dx.doi.org/10.1111/pde.12684DOI Listing
September 2016
4 Reads

Two cases of annular erythema without bullous lesions by autoimmune blistering diseases.

Mod Rheumatol 2018 Jan 19;28(1):200-202. Epub 2015 Oct 19.

a Department of Dermatology , Shiga University of Medical Science , Setatsukinowa , Otsu , Shiga , Japan.

Although annular erythema is usually observed as one of the cutaneous manifestations of Sjögren's syndrome or subacute cutaneous lupus erythematosus, autoimmune blistering diseases also present with annular erythema. However, bullous lesions are not always found, and there is a rare type without bullous lesions. We present two cases of autoimmune blistering diseases showing annular erythema without bullous lesions. Read More

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http://dx.doi.org/10.3109/14397595.2015.1081721DOI Listing
January 2018
3 Reads

Pruritic, Pink Scaling Plaques on the Face and Trunk. Pemphigus erythematosus.

JAMA Dermatol 2015 Oct;151(10):1123-4

Department of Dermatology, Drexel University College of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1001/jamadermatol.2015.2103DOI Listing
October 2015
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Guanine polynucleotides are self-antigens for human natural autoantibodies and are significantly reduced in the human genome.

Immunology 2015 Nov 7;146(3):401-10. Epub 2015 Sep 7.

Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.

In the course of investigating anti-DNA autoantibodies, we examined IgM and IgG antibodies to poly-G and other oligonucleotides in the sera of healthy persons and those diagnosed with systemic lupus erythematosus (SLE), scleroderma (SSc), or pemphigus vulgaris (PV); we used an antigen microarray and informatic analysis. We now report that all of the 135 humans studied, irrespective of health or autoimmune disease, manifested relatively high amounts of IgG antibodies binding to the 20-mer G oligonucleotide (G20); no participants entirely lacked this reactivity. IgG antibodies to homo-nucleotides A20, C20 or T20 were present only in the sera of SLE patients who were positive for antibodies to dsDNA. Read More

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http://doi.wiley.com/10.1111/imm.12514
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http://dx.doi.org/10.1111/imm.12514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610629PMC
November 2015
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Evolutionary medicine and bone loss in chronic inflammatory diseases--A theory of inflammation-related osteopenia.

Semin Arthritis Rheum 2015 Oct 30;45(2):220-8. Epub 2015 Apr 30.

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA.

Objective: Bone loss is typical in chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, ankylosing spondylitis, systemic lupus erythematosus, multiple sclerosis, inflammatory bowel diseases, pemphigus vulgaris, and others. It is also typical in transplantation-related inflammation and during the process of aging. While we recognized that bone loss is tightly linked to immune system activation or inflamm-aging in the form of acute, chronic active, or chronic smoldering inflammation, bone loss is typically discussed to be an "accident of inflammation. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2015.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570856PMC
October 2015
11 Reads