799 results match your criteria Pemphigus Erythematosus


Imatinib induced superficial pemphigus in a patient with gastrointestinal stromal tumor (GIST).

Dermatol Ther 2020 Jun 26. Epub 2020 Jun 26.

Department of Dermatology, Centre de référence des Maladies Bulleuses Auto-immunes - CNR MALIBUL CHU Dupuytren 16 Rue Bernard Descottes 87 042 LIMOGES, France.

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http://dx.doi.org/10.1111/dth.13903DOI Listing

The effects of immunostimulatory herbal supplements on autoimmune skin diseases.

J Am Acad Dermatol 2020 Jun 15. Epub 2020 Jun 15.

Corporal Michael J. Crescenz VAMC, Philadelphia, PA; Department of Dermatology, University of Pennsylvania, Philadelphia, PA. Electronic address:

The use of herbal supplements that promise to improve immune health has gained popularity among dermatology patients. However, there is little to no evidence that herbal supplements improve dermatological conditions. Several in vitro and in vivo studes have shown that Spirulina platensis, Aphanizomenon flos-aqua, Chlorella, Echinacea, and alfalfa activate immune cells, via certain cytokines and chemokines. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.06.037DOI Listing
June 2020
4.449 Impact Factor

Cutaneous polyautoimmunity in two unrelated dogs: pemphigus foliaceus and generalized discoid lupus erythematosus.

Vet Dermatol 2020 Apr 27. Epub 2020 Apr 27.

Department of Clinical Sciences, College of Veterinary Medicine, NC State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.

Background: Polyautoimmunity, the concurrent expression of two or more distinct autoimmune diseases (ADs) in a single individual, is a known phenomenon in humans and has been rarely reported in dogs. To the best of the authors' knowledge, comorbid pemphigus foliaceus (PF) and generalized discoid lupus erythematosus (GDLE) has not been reported in dogs.

Hypothesis/objectives: To describe the clinical, histological and immunological features and treatment outcome of two unrelated dogs with comorbid PF and GDLE. Read More

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http://dx.doi.org/10.1111/vde.12851DOI Listing

Visual Dermatology: Pemphigus Erythematosus (Senear-Usher Syndrome).

J Cutan Med Surg 2020 Mar/Apr;24(2):190

16583 Department of Pathology, Valme University Hospital, Seville, Spain.

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http://dx.doi.org/10.1177/1203475420902054DOI Listing

Vitamin D in autoimmune bullous disease.

Authors:
Stefan Tukaj

Acta Biochim Pol 2020 Feb;67(1):1-5

Department of Molecular Biology, University of Gdańsk, Gdańsk, Poland.

Numerous epidemiological studies have suggested a link between vitamin D deficiency and the development of various autoimmune diseases, including diabetes mellitus type 1, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis or systemic lupus erythematosus. More recently, such a link has been also proposed for autoimmune bullous diseases (AIBD). This is a relatively rare and potentially life-threatening, organ-specific group of inflammatory skin diseases characterized by the presence of tissue-bound and circulating autoantibodies against various molecules present in desmosomes (in pemphigus diseases) or hemidesmosomes (in pemphigoid diseases). Read More

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http://dx.doi.org/10.18388/abp.2020_2905DOI Listing
February 2020

Immune-mediated Skin Disorders and their Oral Manifestations in the Omani Population: A Hospital-based Study.

Oman Med J 2020 Jan 6;35(1):e84. Epub 2020 Jan 6.

Oral Basic Sciences, Oman Dental College, Muscat, Oman.

Objectives: We sought to determine the prevalence of immune-mediated skin disorders (IMDs), their oral manifestations, and the related comorbidity among Omani patients with IMDs attending the outpatient Department of Dermatology and Dental Clinic at Al Nahdha Hospital, Muscat.

Methods: We conducted a retrospective study of 236 newly-diagnosed patients with IMDs who attended the outpatient clinic between September 2014 and September 2017. Data, such as age, sex, investigations, diagnosis, comorbidity, and associated oral manifestations of the affected individuals, were collected from the hospital health information system. Read More

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http://dx.doi.org/10.5001/omj.2020.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976739PMC
January 2020

Association of herpes zoster and chronic inflammatory skin disease in US inpatients.

J Am Acad Dermatol 2020 Jan 17. Epub 2020 Jan 17.

Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC. Electronic address:

Background: Patients with chronic inflammatory skin disease (CISD) have potential risk factors for herpes zoster (HZ). However, little is known about HZ risk in CISD.

Objective: To determine whether CISD is associated with HZ. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.12.073DOI Listing
January 2020

Role of the Complement Pathway in Inflammatory Skin Diseases: A Focus on Hidradenitis Suppurativa.

J Invest Dermatol 2020 Mar 20;140(3):531-536.e1. Epub 2019 Dec 20.

Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Dermatology, Department of Medicine, Women's College Hospital, Toronto, Ontario, Canada. Electronic address:

Although the role of immune dysregulation in hidradenitis suppurativa (HS) has yet to be elucidated, recent studies identified several complement abnormalities in patients with HS. The complement system serves a critical role in the modulation of immune response and regulation of cutaneous commensal bacteria. Complement is implicated in several inflammatory skin diseases including systemic lupus erythematosus, angioedema, pemphigus, bullous pemphigoid, and HS. Read More

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http://dx.doi.org/10.1016/j.jid.2019.09.009DOI Listing
March 2020
7.216 Impact Factor

Brief Update on Dermatologic Uses of Methotrexate

Skin Therapy Lett 2019 Nov;24(6):5-8

Department of Dermatology, McGovern Medical School, The University of Texas Health Sciences Center, Houston, TX, USA

Methotrexate (MTX), an agent originally intended for anti-neoplastic use, has been successfully employed in the treatment of a variety of dermatologic conditions. In addition to its multiple clinical indications, variable dosing and modes of administration make it a viable option for patients of all ages and most comorbidities. MTX is a folate analog that antagonizes dihydrofolate reductase, thus inhibiting thymidylate synthesis and, ultimately, the production of pyrimidine. Read More

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November 2019
5 Reads

B cell targeted therapies in autoimmune disease.

Curr Opin Immunol 2019 12 14;61:92-99. Epub 2019 Nov 14.

Department of Medicine, Division of Allergy Immunology and Rheumatology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, United States. Electronic address:

Purpose Of Review: FDA-approved B cell-targeted therapy has expanded to a multitude of autoimmune diseases ranging from organ specific diseases, like pemphigus and multiple sclerosis, to systemic diseases such as ANCA-associated vasculitis, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). In this review, we discuss the variability in response to B cell-targeted therapies with a focus on the diversity of human B cells and plasma cells, and will discuss several of the promising new B cell-targeted therapies.

Recent Finding: The pathogenic roles for B cells include autoantibody-dependent and autoantibody-independent functions whose importance may vary across diseases or even in subsets of patients with the same disease. Read More

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http://dx.doi.org/10.1016/j.coi.2019.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982404PMC
December 2019

Pemphigus erythematosus and cutaneous epitheliotropic lymphoma in a Labrador Retriever dog.

Iran J Vet Res 2019 ;20(3):221-224

Department of Morphology, Veterinary Faculty, University of Las Palmas de Gran Canaria, Spain.

Background: Paraneoplastic pemphigus is an autoimmune blistering skin disease associated with concurrent neoplasia that is rarely observed in veterinary medicine.

Case Description: This case report presents a ten-year-old female Labrador Retriever dog with generalized seborrhea and alopecic, crusting and ulcerative lesions in the periocular and perioral regions, the lips and the groins.

Findings/treatment And Outcome: Hematology analysis showed a marked increase in the number of lymphocytes, while the rest of the values were normal. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811711PMC
January 2019

[Immunohistochemical analysis for C3d, C4d, IgG, IgG4, and CD123 in diagnosis of autoimmune skin diseases].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Aug;44(8):878-884

Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Objective: To assess the value of immunohistochemical analysis for expressions of C3d, C4d, IgG, IgG4, and CD123 in the diagnosis of autoimmune skin diseases.
 Methods: We investigated the expressions of C3d, C4d, IgG, IgG4, and CD123 in paraffin-embedded, formalin-fixed tissues from 27 lupus erythematosus cases, including 8 discoid lupus erythematosus (DLE) cases, 4 subacute cutaneous lupus erythematosus (SCLE) cases, and 15 systemic lupus erythematosus (SLE) cases. Tissues from 15 dermatomyositis (DM) cases, 15 bullous pemphigoid (BP) cases, and 15 pemphigus cases were examined by immunohistochemical analysis. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2019.180800DOI Listing
August 2019
2 Reads

Systematic Review of Safety and Efficacy of Rituximab in Treating Immune-Mediated Disorders.

Front Immunol 2019 6;10:1990. Epub 2019 Sep 6.

Department of Immunology, University Hospital Zurich, Zurich, Switzerland.

During the past years biologic agents (also termed biologicals or biologics) have become a crucial treatment option in immunological diseases. Numerous articles have been published on biologicals, which complicates the decision making process on the use of the most appropriate biologic for a given immune-mediated disease. This systematic review is the first of a series of articles assessing the safety and efficacy of B cell-targeting biologics for the treatment of immune-mediated diseases. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01990
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http://dx.doi.org/10.3389/fimmu.2019.01990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743223PMC
September 2019
6 Reads

Risk of immune-mediated inflammatory diseases in newly diagnosed ankylosing spondylitis patients: a population-based matched cohort study.

Arthritis Res Ther 2019 08 29;21(1):196. Epub 2019 Aug 29.

Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.

Objective: To investigate the risk of immune-mediated inflammatory diseases (IMIDs) in patients with ankylosing spondylitis (AS).

Methods: Using 2003-2012 claims data from the Taiwanese National Health Insurance Research Database, we identified 30,911 newly diagnosed AS patients requiring medical therapy from 2006 to 2012. In addition, we randomly selected 309,110 non-AS individuals matching (1:10) the AS patients with regard to age, sex and the year of the index date. Read More

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http://dx.doi.org/10.1186/s13075-019-1980-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716905PMC
August 2019
2 Reads
3.753 Impact Factor

Pemphigus Foliaceus and Pemphigus Erythematosus are the Most Common Subtypes of Pemphigus in Northern Finland.

Acta Derm Venereol 2019 Nov;99(12):1127-1130

Department of Dermatology, Mehiläinen Länsi-Pohja Oy, Kemi, Finland. E-mail:

Pemphigus is an autoimmune skin disease characterized by blistering and erosions of the skin and mucous membranes. Pemphigus is rare in Northern and Western Europe but its incidence is higher around the Mediterranean Sea. The most common type worldwide is pemphigus vulgaris. Read More

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http://dx.doi.org/10.2340/00015555-3280DOI Listing
November 2019
1 Read

High-Dose Intravenous Immunoglobulin in Skin Autoimmune Disease.

Front Immunol 2019 11;10:1090. Epub 2019 Jun 11.

Department of Dermatology, University of Heidelberg, Heidelberg, Germany.

The immunomodulatory potential and low incidence of severe side effects of high-dose intravenous immunoglobulin (IVIg) treatment led to its successful application in a variety of dermatological autoimmune diseases over the last two decades. IVIg is usually administered at a dose of 2 g per kg body weight distributed over 2-5 days every 4 weeks. They are most commonly used as a second- or third-line treatment in dermatological autoimmune disease (pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, mucous membrane pemphigoid, epidermolysis bullosa acquisita, dermatomyositis, systemic vasculitis, and systemic lupus erythematosus). Read More

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http://dx.doi.org/10.3389/fimmu.2019.01090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579842PMC
June 2019
10 Reads

Cutaneous effects of antihypertensive drugs.

G Ital Dermatol Venereol 2020 Apr 12;155(2):202-211. Epub 2019 Jun 12.

Section of Dermatology, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.

Introduction: Treatment with antihypertensive drugs may be associated with different dermatological adverse reactions.

Evidence Acquisition: We systematically reviewed the literature available on the MEDLINE (PubMED) databases, up to July 2018. We searched for the terms "calcium-channel blockers" or "angiotensin-converting enzyme inhibitors" or "angiotensin II receptors blockers" or "diuretics" or "beta blockers" AND "dermatological effects" or "skin disease. Read More

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http://dx.doi.org/10.23736/S0392-0488.19.06360-0DOI Listing
April 2020
25 Reads

Oral lichen planus: A disease or a spectrum of tissue reactions? Types, causes, diagnostic algorhythms, prognosis, management strategies.

Periodontol 2000 2019 06;80(1):105-125

UCL Eastman Dental Institute, University College London, London, UK.

Oral lichen planus and lichenoid lesions comprise a group of disorders of the oral mucosa that likely represent a common reaction pattern to 1 or more unknown antigens. The coexistence of hyperkeratotic striation/reticulation, varying degrees of mucosal inflammation from mild erythema to severe widespread ulceration, and a band-like infiltrate of mononuclear inflammatory cells including activated T lymphocytes, macrophages, and dendritic cells, are considered suggestive of oral lichen planus and lichenoid lesions. Several classification systems of oral lichen planus and lichenoid lesions have been attempted, although none seem to be comprehensive. Read More

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http://dx.doi.org/10.1111/prd.12260DOI Listing
June 2019
21 Reads
3.632 Impact Factor

A Clinicopathological and Immunofluorescence Study of Intraepidermal Immunobullous Diseases.

Indian J Dermatol 2019 Mar-Apr;64(2):101-105

Departments of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.

Context: Autoimmune blistering diseases (AIBDs) are characterized by autoantibodies directed against antigens of skin. Direct immunofluorescence (DIF) study helps in confirming the diagnosis where histopathology alone is noncontributory.

Aims: This study aimed to evaluate the clinicopathological and DIF features of intraepidermal AIBD and to assess their relative diagnostic significance. Read More

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http://dx.doi.org/10.4103/ijd.IJD_515_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440185PMC
April 2019
28 Reads

Tubular Hair Casts in Trichoscopy of Hair and Scalp Disorders.

Int J Trichology 2019 Jan-Feb;11(1):14-19

Department of Dermatology, College of Medical Sciences, Bharatpur, Nepal.

Introduction: Hair casts have been reported in a variety of hair and scalp disorders. Trichoscopy allows a quick and noninvasive method for the evaluation of hair and scalp disorders in high magnification. However, the study of hair casts seen in trichoscopy is lacking. Read More

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http://dx.doi.org/10.4103/ijt.ijt_77_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385511PMC
March 2019
55 Reads

Implants in patients with oral manifestations of autoimmune or muco-cutaneous diseases - A systematic review.

Med Oral Patol Oral Cir Bucal 2019 Mar 1;24(2):e217-e230. Epub 2019 Mar 1.

Charité - Universitaetsmedizin Berlin, Charité Centre 3 for Dental, Oral, and Maxillary Medicine, Department for Oral Medicine Dental Radiology, and Oral Surgery, Assmannshauser Str. 4-6, 14197 Berlin, Germany,

Background: To give an overview on implant survival rates in patients with oral manifestations of systemic autoimmune (oral Lichen planus (oLp), Pemphigus (Pe)), muco-cutaneous (Epidermolysis bullosa (EB)), autoimmune multisystemic rheumatic diseases (Sjögren's syndrome (SjS), systemic Lupus erythematosus (sLE), or systemic Sclerosis (sSc)).

Material And Methods: Systematic literature review (PubMed/Medline, Embase) using MESH and search term combinations, published between 1980 and August 2018 in English language reporting on dental implant-prosthetic rehabilitation of patients with oLp, Pe, EB, SjS, sLE, sSc, study design, age, gender, follow-up period (≥ 12 months), implant survival rate. Implant-related weighed mean values of implant survival rate (wmSR) were calculated. Read More

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http://www.medicinaoral.com/medoralfree01/aop/22786.pdf
Publisher Site
http://dx.doi.org/10.4317/medoral.22786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441598PMC
March 2019
14 Reads

Androgen deprivation therapy for prostate cancer and the risk of autoimmune diseases.

Prostate Cancer Prostatic Dis 2019 09 28;22(3):475-482. Epub 2019 Jan 28.

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.

Background: Androgen deprivation therapy (ADT) has been a mainstay of treatment for advanced prostate cancer (PCa), but limited studies have been performed to investigate the association between ADT and autoimmune diseases.

Methods: We conducted a population-based nationwide cohort study of 17,168 patients newly diagnosed with PCa between 1996 and 2013 using the National Health Insurance Research Database (NHIRD) of Taiwan. Cox proportional hazards models with 1:1 propensity score-matched analysis were used to investigate the association between ADT use and the risk of autoimmune diseases. Read More

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http://www.nature.com/articles/s41391-019-0130-9
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http://dx.doi.org/10.1038/s41391-019-0130-9DOI Listing
September 2019
52 Reads

Enzyme-linked immunosorbent assay as a helpful diagnostic tool for pemphigus erythematosus with equivocal histologic and immunofluorescent findings.

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

Department of Dermatology, University of Central Florida College of Medicine, Orlando, Florida.

Enzyme-linked immunosorbent assay is a sensitive and specific method for the detection of circulating autoantibodies in pemphigus vulgaris and foliaceus. Herein, pemphigus erythematosus with equivocal immunofluorescence and non-diagnostic histology, but confirmed by enzyme-linked immunosorbent assay, is described. As a non-invasive, sensitive, and specific assay with additional utility for monitoring disease activity, this case adds to growing evidence supporting ELISA as the diagnostic method of choice for common and less common variants of pemphigus. Read More

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August 2018
30 Reads

The relationship between pemphigus and systemic lupus erythematosus: a cross-sectional study, systematic review, and meta-analysis.

Immunol Res 2019 02;67(1):116-122

Department of Quality Measurements and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel.

The coexistence of pemphigus and systemic lupus erythematosus (SLE) had been reported anecdotally. Anti-desmoglein (Dsg)1 and anti-Dsg3 antibodies were detected concomitantly with antinuclear autoantibodies among blood donors. The aim of the current study was to study the association between pemphigus and SLE in Israeli patients and to synthesize existing data on this association in the current literature. Read More

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http://link.springer.com/10.1007/s12026-019-9065-4
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http://dx.doi.org/10.1007/s12026-019-9065-4DOI Listing
February 2019
33 Reads

Systematic review of rituximab for autoimmune diseases: a potential alternative to intravenous immune globulin.

Transfusion 2018 11 23;58(11):2729-2735. Epub 2018 Sep 23.

Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

Background: The anti-CD20 monoclonal antibody rituximab has immune-modulatory effects similar to intravenous immunoglobulin (IVIG). We performed a systematic review and meta-analysis to determine the efficacy and safety of rituximab in autoimmune diseases that are also treated with IVIG.

Study Design And Methods: The most common indications for immune modulation with IVIG, as identified from a 2012 regional audit in Canada, were chronic inflammatory demyelinating polyneuropathy (CIDP), immune thrombocytopenia (ITP), myasthenia gravis, multifocal motor neuropathy, Guillain-Barré syndrome, systemic lupus erythematosus (SLE), Sjogren's syndrome, and pemphigus vulgaris. Read More

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http://dx.doi.org/10.1111/trf.14841DOI Listing
November 2018
18 Reads

Diagnosing Pemphigus Foliaceus: A Rare Blistering Disease Masquerading as a Common Dermatologic Disorder.

Mil Med 2019 05;184(5-6):e455-e457

Department of Dermatology, San Antonio Military Health System, 3551 Roger Brooke Drive, San Antonio, TX.

Pemphigus foliaceus (PF) is an autoimmune dermatologic disease that typically presents with painful, superficial blisters that evolve into scaling erosions in a seborrheic distribution. This case study intends to demonstrate that due to the relative scarcity of the disease and its distribution on the body, PF can easily be misdiagnosed. We present a 43-year-old African American male that presented to the dermatology clinic with an 18-month history of non-pruritic, violaceous, scaling patches and plaques most prominent on the malar cheeks, upper chest and upper back. Read More

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http://dx.doi.org/10.1093/milmed/usy224DOI Listing
May 2019
6 Reads

Autoimmune skin disease among dermatology outpatients in Botswana: a retrospective review.

Int J Dermatol 2019 Jan 31;58(1):50-53. Epub 2018 Aug 31.

Department of Dermatology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Background: There is a paucity of data describing autoimmune skin diseases in sub-Saharan Africa and in HIV positive cohorts. We describe the incidence of autoimmune skin diseases in public dermatology clinics in Botswana.

Methods: New patient records from public dermatology clinics were reviewed retrospectively for the period of September 2008 to December 2015. Read More

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http://dx.doi.org/10.1111/ijd.14201DOI Listing
January 2019
51 Reads
1.230 Impact Factor

Fogo selvagem: endemic pemphigus foliaceus.

An Bras Dermatol 2018 Sep-Oct;93(5):638-650

Dermatology Service, Hospital Maria Aparecida Pedrossian, Universidade Federal de Mato Grosso do Sul, Campo Grande (MS), Brazil.

Fogo selvagem or endemic pemphigus foliaceus is an autoimmune acantholytic anti-cadherin bullous disease that primarily affects seborrheic areas, which might disseminate. Brazil has the world's largest number of patients, mainly in the Central-West region, but the disease has also been reported in other South American countries. It affects young people and adults who have been exposed to rural areas, with occurrence of familial cases. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20188235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106655PMC
October 2018
45 Reads

Autoimmune Diseases and Their Manifestations on Oral Cavity: Diagnosis and Clinical Management.

J Immunol Res 2018 27;2018:6061825. Epub 2018 May 27.

Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Viale Regina Elena 287a, 00161 Rome, Italy.

Oral signs are frequently the first manifestation of autoimmune diseases. For this reason, dentists play an important role in the detection of emerging autoimmune pathologies. Indeed, an early diagnosis can play a decisive role in improving the quality of treatment strategies as well as quality of life. Read More

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https://www.hindawi.com/journals/jir/2018/6061825/
Publisher Site
http://dx.doi.org/10.1155/2018/6061825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994274PMC
October 2018
16 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Periodontol 2018 06;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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http://doi.wiley.com/10.1002/JPER.17-0719
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http://dx.doi.org/10.1002/JPER.17-0719DOI Listing
June 2018
74 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Clin Periodontol 2018 06;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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http://dx.doi.org/10.1111/jcpe.12940DOI Listing
June 2018
103 Reads

New biochip immunofluorescence test for the serological diagnosis of pemphigus vulgaris and foliaceus: A review of the literature.

Int J Womens Dermatol 2018 Jun 3;4(2):102-108. Epub 2018 Feb 3.

Department of Dermatology, St George Hospital, Sydney, New South Wales, Australia.

The immunoassays that are available for the serological diagnosis of the more common subtypes of autoimmune blistering diseases such as pemphigus vulgaris (PV) and pemphigus foliaceus (PF) include enzyme-linked immunosorbent assay (ELISA) testing to specific antigens desmoglein (Dsg)1 and Dsg3, direct immunofluorescence (DIF), indirect immunofluorescence (IIF), and immunoblotting. A review of the literature on the biochip assay was conducted. Six studies investigated the validity of a new biochip, mosaic-based, IIF test in patients with pemphigus and demonstrated its relatively high sensitivity and specificity (Dsg3: 97. Read More

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http://dx.doi.org/10.1016/j.ijwd.2017.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986232PMC
June 2018
8 Reads

A rare case with prominent features of both discoid lupus erythematosus and pemphigus foliaceus.

J Eur Acad Dermatol Venereol 2019 Jan 13;33(1):e5-e7. Epub 2018 Jun 13.

Department of Dermatology, Center for Blistering Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1111/jdv.15099DOI Listing
January 2019
5 Reads

Intravenous immunoglobulins in dermatology. Part 2: clinical indications and outcomes.

Clin Exp Dermatol 2018 Aug 17;43(6):659-666. Epub 2018 May 17.

Dermatological Surgery and Laser Unit, St John's Institute of Dermatology, Guy's Hospital Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, UK.

Intravenous immunoglobulin (IVIg) is a solution of human IgG, salt, sugars and solvents used to treat a multitude of diseases. Although IVIg has been known to treat many diseases safely and successfully, there are relatively few supporting randomized controlled trials. In part two of this review, we assess the clinical indications of IVIg in dermatological disorders and the outcomes of its use. Read More

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http://dx.doi.org/10.1111/ced.13552DOI Listing
August 2018
6 Reads

Unusually extensive scalp ulcerations manifested in pemphigus erythematosus.

Dermatol Online J 2018 Jan 15;24(1). Epub 2018 Jan 15.

University of Illinois College of Medicine, Chicago, Illinois.

Senear-Usher Syndrome, or pemphigus erythematosus, is an autoimmune skin blistering disorder with an overlapping clinical presentation of pemphigus foliaceus and lupus erythematosus. Lesions typically involve the scalp, face, and upper chest or back. This case study focuses on a patient who presentedwith progressive scalp ulcers, hyperpigmentation, and eroded plaques with overlying hemorrhagic crust. Read More

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January 2018
11 Reads

Gene Expression Analysis Reveals Novel Shared Gene Signatures and Candidate Molecular Mechanisms between Pemphigus and Systemic Lupus Erythematosus in CD4 T Cells.

Front Immunol 2017 17;8:1992. Epub 2018 Jan 17.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

Pemphigus and systemic lupus erythematosus (SLE) are severe potentially life-threatening autoimmune diseases. They are classified as B-cell-mediated autoimmune diseases, both depending on autoreactive CD4 T lymphocytes to modulate the autoimmune B-cell response. Despite the reported association of pemphigus and SLE, the molecular mechanisms underlying their comorbidity remain unknown. Read More

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http://dx.doi.org/10.3389/fimmu.2017.01992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776326PMC
January 2018
14 Reads

High-dose intravenous immunoglobulins for the treatment of dermatological autoimmune diseases.

J Dtsch Dermatol Ges 2017 Dec;15(12):1211-1226

Department of Dermatology, University of Heidelberg, Heidelberg, Germany.

Based on their immunomodulatory properties, high-dose intravenous immunoglobulins (IVIGs) are successfully used in the treatment of various dermatological autoimmune diseases, in particular pemphigus vulgaris and dermatomyositis. In autoimmune bullous diseases, IVIGs can be used in an adjuvant setting (second- or third-line therapy) once combined immunosuppressive regimens have failed. In dermatomyositis, IVIGs may already be employed as an adjuvant second-line therapy after failure of corticosteroid monotherapy. Read More

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http://dx.doi.org/10.1111/ddg.13389DOI Listing
December 2017
35 Reads

Oral Manifestation in Patients diagnosed with Dermatological Diseases.

J Contemp Dent Pract 2017 Dec 1;18(12):1153-1158. Epub 2017 Dec 1.

Department of Oral Pathology and Microbiology, M. A. Rangoonwala College of Dental Sciences & Research Centre Pune, Maharashtra, India.

Aim: This study aimed to estimate the frequency of oral lesions in dermatological diseased patients attending the outpatient department of Pravara Rural Medical and Dental College and Hospital, Pravara Institute of Medical Sciences (Deemed University), Loni, Ahmednagar, Maharashtra, India, and the Department of Dermatology at Medical College, Ahmednagar, Maharashtra, India.

Materials And Methods: A cross-sectional hospital-based study was conducted in Loni from October 2013 to January 2014. A total of 310 patients (mean age 37. Read More

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http://dx.doi.org/10.5005/jp-journals-10024-2191DOI Listing
December 2017
12 Reads

Peripheral CD19 B cells exhibit activated phenotype and functionality in promoting IgG and IgM production in human autoimmune diseases.

Sci Rep 2017 10 24;7(1):13921. Epub 2017 Oct 24.

Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, P. R. China.

Systemic Lupus Erythematosus (SLE) and pemphigus are two representative autoimmune diseases driven by pathogenic autoantibody systemically and organ-specifically, respectively. Given the involvement of antibody in the pathogenesis, B cells are inclined to differentiate and function in an abnormal activation model. Here we defined a unique CD19 B cell population existing in the periphery of SLE and pemphigus patients as well as in human tonsils. Read More

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http://dx.doi.org/10.1038/s41598-017-14089-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655037PMC
October 2017
17 Reads

Human papillomavirus vaccination of adult women and risk of autoimmune and neurological diseases.

J Intern Med 2018 02 18;283(2):154-165. Epub 2017 Oct 18.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Background: Since 2006, human papillomavirus (HPV) vaccines have been introduced in many countries worldwide. Whilst safety studies have been reassuring, focus has been on the primary target group, the young adolescent girls. However, it is also important to evaluate safety in adult women where background disease rates and safety issues could differ significantly. Read More

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http://dx.doi.org/10.1111/joim.12694DOI Listing
February 2018
11 Reads

Spectrum of orocutaneous disease associations: Immune-mediated conditions.

J Am Acad Dermatol 2017 Nov;77(5):795-806

Division of Dermatology, Baylor University Medical Center, Dallas, Texas. Electronic address:

There are a number of diseases that manifest both on the skin and the oral mucosa, and therefore the importance for dermatologists in clinical practice to be aware of these associations is paramount. In the following continuing medical education series, we outline orocutaneous disease associations with both immunologic and inflammatory etiologies. Read More

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http://dx.doi.org/10.1016/j.jaad.2017.02.019DOI Listing
November 2017
34 Reads

Evaluation of Anti-Cyclic Citrullinated Peptide Autoantibodies and C-Reactive Protein in Common Autoimmune Skin Diseases with and without Arthritis.

J Clin Diagn Res 2017 Jul 1;11(7):BC06-BC08. Epub 2017 Jul 1.

Professor and Hod, Department of Skin and VD, Patna Medical College and Hospital, Patna, Bihar, India.

Introduction: Anti-Cyclic Citrullinated Peptides (CCPs) are a well known diagnostic and prognostic noble marker for rheumatoid arthritis. C-Reactive Protein (CRP) is an acute phase protein whose level rises in response to inflammation.

Aim: This study was undertaken to show the role of the two markers (anti-CCPs and CRP) in autoimmune skin disorder and their association with associated arthritis in these disorder. Read More

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http://dx.doi.org/10.7860/JCDR/2017/27234.10176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583789PMC
July 2017
14 Reads

Survey of False-positive Reactivity of Latex Agglutination Test for Kala-azar (Katex) without Urine Sample Boiling Process in Autoimmune Patients.

Iran J Public Health 2017 Jun;46(6):804-810

Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Background: Latex agglutination test for Kala-azar (KAtex) is an easy, inexpensive, and field-applicable antigen detection test. However, the main drawback of this method is the boiling step applied to remove false positivity of the test. This study was conducted to survey false positivity results of latex agglutination test for KAtex without boiling process in urine of some autoimmune patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558074PMC
June 2017
14 Reads

The Value of Direct Immunofluorescence on Proteinase-Digested Formalin-Fixed Paraffin-Embedded Skin Biopsies.

Am J Dermatopathol 2018 Feb;40(2):111-117

Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA.

Direct immunofluorescence (DIF) on frozen tissue (DIF-F) is the method of choice for the identification of immune deposits present in skin and other tissues. DIF can also be performed on formalin-fixed paraffin-embedded tissue (DIF-P) after antigen retrieval with proteases and has proven to be of value in renal pathology. However, its utility in skin biopsies has not been fully examined. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000934DOI Listing
February 2018
41 Reads

Comorbid autoimmune diseases in patients with pemphigus: a nationwide case-control study in Taiwan.

Eur J Dermatol 2017 Aug;27(4):375-381

Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Dermatology, National Yang-Ming University, Taipei, Taiwan.

Previous studies have proposed the association between pemphigus and several autoimmune diseases, but no large-scale study has been reported. To delineate the association between pemphigus and autoimmune diseases including psoriasis. A total of 1,998 patients with pemphigus and 7,992 control subjects were enrolled from the National Health Insurance Research Database in Taiwan from 1997 to 2010. Read More

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http://dx.doi.org/10.1684/ejd.2017.3060DOI Listing
August 2017
7 Reads

Generalized Discoid Lupus Erythematosus as the Presenting Sign of Small Cell Lung Carcinoma.

Skinmed 2017;15(3):218-220. Epub 2017 Jun 1.

Department of Dermatology, Mayo Clinic, Rochester, MN.

A 46-year-old woman with a 30 pack-year smoking history presented with a worsening eruption on the left cheek that failed to improve with metronidazole gel. The cutaneous eruption spread to most of her face and did not respond to a brief tapering course of prednisone. During the initial evaluation at our institution, approximately 6 weeks after the onset of the cutaneous eruption, the patient had erythematous, crusted plaques on her face and scalp (Figure 1A); they were also present on the V-area of the anterior aspect of the neck and upper region of the chest, the shoulders, and the arms, with isolated lesions on the trunk and legs. Read More

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August 2019
20 Reads

Robust memory responses against influenza vaccination in pemphigus patients previously treated with rituximab.

JCI Insight 2017 Jun 15;2(12). Epub 2017 Jun 15.

Department of Pediatrics, Division of Infectious Disease.

Rituximab is a therapeutic anti-CD20 monoclonal antibody widely used to treat B cell lymphoma and autoimmune diseases, such as rheumatic arthritis, systemic lupus erythematosus, and autoimmune blistering skin diseases (AIBD). While rituximab fully depletes peripheral blood B cells, it remains unclear whether some preexisting B cell memory to pathogens or vaccines may survive depletion, especially in lymphoid tissues, and if these memory B cells can undergo homeostatic expansion during recovery from depletion. The limited data available on vaccine efficacy in this setting have been derived from rituximab-treated patients receiving concomitant chemotherapy or other potent immunosuppressants. Read More

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https://insight.jci.org/articles/view/93222
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http://dx.doi.org/10.1172/jci.insight.93222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470882PMC
June 2017
37 Reads

[Safety and efficacy of off-label use of biologic therapies in patients with inflammatory rheumatic diseases refractory to standard of care therapy : Data from a nationwide German registry (GRAID2)].

Z Rheumatol 2018 Feb;77(1):28-39

Medizinische Klinik m.S. Rheumatologie und Klinische Immunologie, Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Deutschland.

Background: The German Registry of Autoimmune Diseases 2 (GRAID2) is a retrospective, non-interventional, multicenter registry study collecting data from patients with inflammatory, mainly rheumatic diseases refractory to standard of care therapy and treated with an off-label biologic therapy. The retrospective documentation comprised case history, diagnosis, course of disease (including safety and global efficacy). The objective was to evaluate the global clinical outcome and safety of off-label biologic therapy in clinical practice. Read More

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http://dx.doi.org/10.1007/s00393-017-0330-4DOI Listing
February 2018
10 Reads