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    763 results match your criteria Pemphigus Erythematosus

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    Unusually extensive scalp ulcerations manifested in pemphigus erythematosus.
    Dermatol Online J 2018 Jan 15;24(1). Epub 2018 Jan 15.
    University of Illinois College of Medicine, Chicago, Illinois.
    Senear-Usher Syndrome, or pemphigus erythematosus, is an autoimmune skin blistering disorder with an overlapping clinical presentation of pemphigus foliaceus and lupus erythematosus. Lesions typically involve the scalp, face, and upper chest or back. This case study focuses on a patient who presentedwith progressive scalp ulcers, hyperpigmentation, and eroded plaques with overlying hemorrhagic crust. Read More

    Gene Expression Analysis Reveals Novel Shared Gene Signatures and Candidate Molecular Mechanisms between Pemphigus and Systemic Lupus Erythematosus in CD4 T Cells.
    Front Immunol 2017 17;8:1992. Epub 2018 Jan 17.
    Department of Dermatology, University of Lübeck, Lübeck, Germany.
    Pemphigus and systemic lupus erythematosus (SLE) are severe potentially life-threatening autoimmune diseases. They are classified as B-cell-mediated autoimmune diseases, both depending on autoreactive CD4 T lymphocytes to modulate the autoimmune B-cell response. Despite the reported association of pemphigus and SLE, the molecular mechanisms underlying their comorbidity remain unknown. Read More

    High-dose intravenous immunoglobulins for the treatment of dermatological autoimmune diseases.
    J Dtsch Dermatol Ges 2017 Dec;15(12):1211-1226
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany.
    Based on their immunomodulatory properties, high-dose intravenous immunoglobulins (IVIGs) are successfully used in the treatment of various dermatological autoimmune diseases, in particular pemphigus vulgaris and dermatomyositis. In autoimmune bullous diseases, IVIGs can be used in an adjuvant setting (second- or third-line therapy) once combined immunosuppressive regimens have failed. In dermatomyositis, IVIGs may already be employed as an adjuvant second-line therapy after failure of corticosteroid monotherapy. Read More

    Oral Manifestation in Patients diagnosed with Dermatological Diseases.
    J Contemp Dent Pract 2017 Dec 1;18(12):1153-1158. Epub 2017 Dec 1.
    Department of Oral Pathology and Microbiology, M. A. Rangoonwala College of Dental Sciences & Research Centre Pune, Maharashtra, India.
    Aim: This study aimed to estimate the frequency of oral lesions in dermatological diseased patients attending the outpatient department of Pravara Rural Medical and Dental College and Hospital, Pravara Institute of Medical Sciences (Deemed University), Loni, Ahmednagar, Maharashtra, India, and the Department of Dermatology at Medical College, Ahmednagar, Maharashtra, India.

    Materials And Methods: A cross-sectional hospital-based study was conducted in Loni from October 2013 to January 2014. A total of 310 patients (mean age 37. Read More

    Peripheral CD19 B cells exhibit activated phenotype and functionality in promoting IgG and IgM production in human autoimmune diseases.
    Sci Rep 2017 Oct 24;7(1):13921. Epub 2017 Oct 24.
    Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, P. R. China.
    Systemic Lupus Erythematosus (SLE) and pemphigus are two representative autoimmune diseases driven by pathogenic autoantibody systemically and organ-specifically, respectively. Given the involvement of antibody in the pathogenesis, B cells are inclined to differentiate and function in an abnormal activation model. Here we defined a unique CD19 B cell population existing in the periphery of SLE and pemphigus patients as well as in human tonsils. Read More

    Human papillomavirus vaccination of adult women and risk of autoimmune and neurological diseases.
    J Intern Med 2018 Feb 18;283(2):154-165. Epub 2017 Oct 18.
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Background: Since 2006, human papillomavirus (HPV) vaccines have been introduced in many countries worldwide. Whilst safety studies have been reassuring, focus has been on the primary target group, the young adolescent girls. However, it is also important to evaluate safety in adult women where background disease rates and safety issues could differ significantly. Read More

    Spectrum of orocutaneous disease associations: Immune-mediated conditions.
    J Am Acad Dermatol 2017 Nov;77(5):795-806
    Division of Dermatology, Baylor University Medical Center, Dallas, Texas. Electronic address:
    There are a number of diseases that manifest both on the skin and the oral mucosa, and therefore the importance for dermatologists in clinical practice to be aware of these associations is paramount. In the following continuing medical education series, we outline orocutaneous disease associations with both immunologic and inflammatory etiologies. Read More

    Evaluation of Anti-Cyclic Citrullinated Peptide Autoantibodies and C-Reactive Protein in Common Autoimmune Skin Diseases with and without Arthritis.
    J Clin Diagn Res 2017 Jul 1;11(7):BC06-BC08. Epub 2017 Jul 1.
    Professor and Hod, Department of Skin and VD, Patna Medical College and Hospital, Patna, Bihar, India.
    Introduction: Anti-Cyclic Citrullinated Peptides (CCPs) are a well known diagnostic and prognostic noble marker for rheumatoid arthritis. C-Reactive Protein (CRP) is an acute phase protein whose level rises in response to inflammation.

    Aim: This study was undertaken to show the role of the two markers (anti-CCPs and CRP) in autoimmune skin disorder and their association with associated arthritis in these disorder. Read More

    Survey of False-positive Reactivity of Latex Agglutination Test for Kala-azar (Katex) without Urine Sample Boiling Process in Autoimmune Patients.
    Iran J Public Health 2017 Jun;46(6):804-810
    Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.
    Background: Latex agglutination test for Kala-azar (KAtex) is an easy, inexpensive, and field-applicable antigen detection test. However, the main drawback of this method is the boiling step applied to remove false positivity of the test. This study was conducted to survey false positivity results of latex agglutination test for KAtex without boiling process in urine of some autoimmune patients. Read More

    The Value of Direct Immunofluorescence on Proteinase-Digested Formalin-Fixed Paraffin-Embedded Skin Biopsies.
    Am J Dermatopathol 2018 Feb;40(2):111-117
    Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA.
    Direct immunofluorescence (DIF) on frozen tissue (DIF-F) is the method of choice for the identification of immune deposits present in skin and other tissues. DIF can also be performed on formalin-fixed paraffin-embedded tissue (DIF-P) after antigen retrieval with proteases and has proven to be of value in renal pathology. However, its utility in skin biopsies has not been fully examined. Read More

    Comorbid autoimmune diseases in patients with pemphigus: a nationwide case-control study in Taiwan.
    Eur J Dermatol 2017 Aug;27(4):375-381
    Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Dermatology, National Yang-Ming University, Taipei, Taiwan.
    Previous studies have proposed the association between pemphigus and several autoimmune diseases, but no large-scale study has been reported. To delineate the association between pemphigus and autoimmune diseases including psoriasis. A total of 1,998 patients with pemphigus and 7,992 control subjects were enrolled from the National Health Insurance Research Database in Taiwan from 1997 to 2010. Read More

    Generalized Discoid Lupus Erythematosus as the Presenting Sign of Small Cell Lung Carcinoma.
    Skinmed 2017 1;15(3):218-220. Epub 2017 Jun 1.
    Department of Dermatology, Mayo Clinic, Rochester, MN.
    A 46-year-old woman with a 30 pack-year smoking history presented with a worsening eruption on the left cheek that failed to improve with metronidazole gel. The cutaneous eruption spread to most of her face and did not respond to a brief tapering course of prednisone. During the initial evaluation at our institution, approximately 6 weeks after the onset of the cutaneous eruption, the patient had erythematous, crusted plaques on her face and scalp (Figure 1A); they were also present on the V-area of the anterior aspect of the neck and upper region of the chest, the shoulders, and the arms, with isolated lesions on the trunk and legs. Read More

    Robust memory responses against influenza vaccination in pemphigus patients previously treated with rituximab.
    JCI Insight 2017 Jun 15;2(12). Epub 2017 Jun 15.
    Department of Pediatrics, Division of Infectious Disease.
    Rituximab is a therapeutic anti-CD20 monoclonal antibody widely used to treat B cell lymphoma and autoimmune diseases, such as rheumatic arthritis, systemic lupus erythematosus, and autoimmune blistering skin diseases (AIBD). While rituximab fully depletes peripheral blood B cells, it remains unclear whether some preexisting B cell memory to pathogens or vaccines may survive depletion, especially in lymphoid tissues, and if these memory B cells can undergo homeostatic expansion during recovery from depletion. The limited data available on vaccine efficacy in this setting have been derived from rituximab-treated patients receiving concomitant chemotherapy or other potent immunosuppressants. Read More

    [Safety and efficacy of off-label use of biologic therapies in patients with inflammatory rheumatic diseases refractory to standard of care therapy : Data from a nationwide German registry (GRAID2)].
    Z Rheumatol 2018 Feb;77(1):28-39
    Medizinische Klinik m.S. Rheumatologie und Klinische Immunologie, Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Deutschland.
    Background: The German Registry of Autoimmune Diseases 2 (GRAID2) is a retrospective, non-interventional, multicenter registry study collecting data from patients with inflammatory, mainly rheumatic diseases refractory to standard of care therapy and treated with an off-label biologic therapy. The retrospective documentation comprised case history, diagnosis, course of disease (including safety and global efficacy). The objective was to evaluate the global clinical outcome and safety of off-label biologic therapy in clinical practice. Read More

    Evaluation of prolactin levels in patients with newly diagnosed pemphigus vulgaris and its correlation with pemphigus disease area index.
    Int J Womens Dermatol 2016 Jun 23;2(2):53-55. Epub 2016 Apr 23.
    Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Prolactin is a hormone; in addition to it known roles, it has immunomodulatory effects on lymphocytes maturation and immunoglobulins production. Hyperprolactinemia has been demonstrated in various autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, type I diabetes mellitus, and Graves' disease. In view of the prolactin immunomodulatory roles, studying prolactin levels in pemphigus as an autoimmune blistering disease may introduce new ways of understanding disease etiology and developing treatment strategies. Read More

    A study of clinical, histopathological and direct immunofluorescence diagnosis in pemphigus group Utility of direct immunofluorescence.
    Bratisl Lek Listy 2017 ;118(4):243-249
    Aims: To determine the diagnostic accordance between histopathological and direct immunofluorescence diagnosis of patients with autoimmune vesiculobullous skin diseases.

    Background: The term pemphigus refers to a group of autoimmune blistering diseases mediated by auto-antibodies directed against desmoglein proteins. The differentiation between the various bullous diseases is important for treatment and prognosis. Read More

    [Thymoma and autoimmune diseases].
    Rev Med Interne 2018 Jan 30;39(1):17-26. Epub 2017 Mar 30.
    Service de médecine interne, hospices civils de Lyon, hôpital de la Croix-Rousse, université Claude-Bernard - Lyon 1, 103, grande rue de la Croix-Rousse, 69004 Lyon, France.
    The association between thymoma and autoimmunity is well known. Besides myasthenia gravis, which is found in 15 to 20% of patients with thymoma, other autoimmune diseases have been reported: erythroblastopenia, systemic lupus erythematosus, inflammatory myopathies, thyroid disorders, Isaac's syndrome or Good's syndrome. More anecdotally, Morvan's syndrome, limbic encephalitis, other autoimmune cytopenias, autoimmune hepatitis, and bullous skin diseases (pemphigus, lichen) have been reported. Read More

    Immunopathogenic Oral Diseases: An Overview 
Focusing on Pemphigus Vulgaris and Mucous Membrane Pemphigoid.
    Oral Health Prev Dent 2017;15(2):177-182
    Pemphigus vulgaris, mucosal pemphigoid (mucous membrane pemphigoid), lichen planus, discoid lupus erythematosus and erythema multiforme are a group of immune-mediated mucocutaneous disorders characterised clinically by the formation of blisters, erosions or ulcers. The oral mucosa is often affected, and sometimes the disease is limited to the mouth. The target antigens, autoreactive immune responses, microscopic features, treatment and prognosis vary from one disease to the other. Read More

    Pathogenic mechanisms of IgE-mediated inflammation in self-destructive autoimmune responses.
    Autoimmunity 2017 Feb;50(1):25-36
    a Department of Respiratory , Inflammation & Autoimmunity, MedImmune LLC , Gaithersburg , MD , USA.
    Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years. Despite their role in allergies, IgE autoantibodies are not associated with a higher rate of atopy in these patients. Read More

    Gonadectomy effects on the risk of immune disorders in the dog: a retrospective study.
    BMC Vet Res 2016 Dec 8;12(1):278. Epub 2016 Dec 8.
    Department of Animal Science, University of California, One Shields Ave, Davis, CA, 95616, USA.
    Background: Gonadectomy is one of the most common procedures performed on dogs in the United States. Neutering has been shown to reduce the risk for some diseases although recent reports suggest increased prevalence for structural disorders and some neoplasias. The relation between neuter status and autoimmune diseases has not been explored. Read More

    Autoimmune swallowing disorders.
    Curr Opin Otolaryngol Head Neck Surg 2016 Dec;24(6):483-488
    aMclaren Oakland Hospital, Pontiac bMichigan State University College of Osteopathic Medicine, East Lansing cMichigan State University, East Lansing dSt. John Macomb Hospital, Madison Heights eOakland University William Beaumont School of Medicine, Rochester fLakeshore Professional Voice Center, St. Clair Shores, Michigan, USA.
    Purpose Of Review: Dysphagia can be the presenting symptom of autoimmune disease. The otolaryngologist should be familiar with and consider these disorders when assessing the patient with swallowing difficulties.

    Recent Findings: The present review gives a brief overview of Sjogren's syndrome, granulomatosis with polyangiitis, pemphigus and pemphigoid, rheumatoid arthritis, systemic lupus erythematosus, scleroderma and inflammatory myopathies, and how they affect swallowing. Read More

    Significance of Anti-cyclic Citrullinated Peptide Autoantibodies in Immune-mediated Inflammatory Skin Disorders with and without Arthritis.
    Indian J Dermatol 2016 Sep-Oct;61(5):510-4
    Department of Microbiology, University College of Medical Sciences (UCMS) and GTB Hospital, New Delhi, India.
    Background: Anti-cyclic citrullinated peptides (CCPs) are autoantibodies directed against citrullinated peptides. Rheumatoid factor (RF), an antibody against the Fc portion of IgG, is known to form immune complexes and contribute to the etiopathogenesis of various skin disorders. C-reactive protein (CRP), an acute-phase protein, increases following secretion of interleukin-6 from macrophages and T cells. Read More

    Effects of Miconazole Oral Gel on Blood Concentrations of Tacrolimus and Cyclosporine: A Retrospective Observational Study.
    Ther Drug Monit 2016 12;38(6):717-721
    *Department of Pharmacy, Medical Hospital, Tokyo Medical and Dental University (TMDU); Departments of †Rheumatology and ‡Pharmacokinetics and Pharmacodynamics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
    Background: Although azole antifungal agents have been shown to affect the pharmacokinetics of calcineurin inhibitors such as tacrolimus (TAC) and cyclosporine (CyA) by inhibiting drug metabolism, there are few clinical reports on drug interactions between miconazole (MCZ) oral gel and calcineurin inhibitors. In this study, the effects of MCZ oral gel on the blood concentrations of TAC and CyA were investigated.

    Methods: In this retrospective study, 18 patients concomitantly administered MCZ oral gel and TAC (9 for dermatomyositis, 3 for myasthenia gravis, 2 for systemic lupus erythematosus, 2 for rheumatoid arthritis, 1 for polymyositis, 1 for prevention of graft-versus-host disease after bone marrow transplantation), and 15 patients concomitantly administered MCZ oral gel and CyA (11 for interstitial pneumonia, 2 for pemphigus, 1 for eosinophilic granulomatosis with polyangiitis, 1 for systemic lupus erythematosus) were evaluated. Read More

    The incidence of herpes zoster in cutaneous lupus erythematosus (CLE), dermatomyositis (DM), pemphigus vulgaris (PV), and bullous pemphigoid (BP).
    J Am Acad Dermatol 2016 Jul;75(1):42-8
    Corporal Michael J. Crescenz Department of Veterans Affairs Medical Center, Philadelphia, Pennsylvania; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    Background: Herpes zoster is a common condition that causes significant morbidity.

    Objective: This study determined the incidence of zoster in patients with cutaneous lupus erythematosus (CLE), dermatomyositis (DM), pemphigus vulgaris (PV), and bullous pemphigoid (BP).

    Methods: In this retrospective cohort study the electronic medical records of 186 patients with CLE, 103 with DM, 83 with PV, 44 with BP, and 152 healthy control patients were reviewed to confirm positive diagnoses of zoster. Read More

    New Insights into the Management of Patients with Autoimmune Diseases or Inflammatory Disorders During Pregnancy.
    Scand J Immunol 2016 Sep;84(3):146-9
    Department of medical microbiology, school of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    The treatment of autoimmune diseases remains a serious problem. Current therapies can lead to adverse effects in patients. One of the most vulnerable patient groups is pregnant women. Read More

    Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy.
    Australas J Dermatol 2017 Aug 7;58(3):e120-e122. Epub 2016 Jun 7.
    Faculty of Life Sciences, Department of Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan.
    A 65-year-old woman had undergone a thymectomy for thymoma and 1 year after surgery she developed scattered erosive erythema with scaling and crusting. Examination findings exhibited the elevation of anti-dsDNA antibody, anti-desmoglein 1 antibody, anti-acetylcholine receptor antibody and anti-thyroglobulin antibody. A skin biopsy showed intraepidermal blisters containing neutrophils and acantholytic keratinocytes and direct immunofluorescence revealed the deposition of immunoglobulin G in the epidermis and on the basement membrane. Read More

    Management of rheumatic and autoimmune blistering disease in pregnancy and postpartum.
    Clin Dermatol 2016 May-Jun;34(3):344-52. Epub 2016 Feb 9.
    Department of Dermatology, Perelman School of Medicine, Philadelphia, Pennsylvania; Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania. Electronic address:
    The treatment of rheumatic and autoimmune skin disease in women who are pregnant or of childbearing potential can present challenges to the dermatologist. We discuss the current approaches to treating lupus erythematosus, antiphospholipid antibody syndrome, dermatomyositis, morphea and systemic sclerosis, mixed connective tissue disease, rheumatoid arthritis, and autoimmune blistering disease in such patients. In the appropriate setting, topical and systemic corticosteroids, hydroxychloroquine, dapsone, azathioprine, and ultraviolet B phototherapy may be safely and cautiously used during pregnancy. Read More

    Skin diseases of the nose.
    Am J Rhinol Allergy 2016 May;30(3):83-90
    Otorhinolaryngology and Head and Neck Surgery Clinic, Bakirkoy Dr Sadi Konuk Research and Training Hospital, Istanbul, Turkey.
    Objectives: The goal of this study was to review the main lesion types of the nasal skin and appropriate treatment strategies rather than to present a comprehensive list of all diseases that affect the skin that can involve the nose.

    Methods: We reviewed the main nasal skin lesion types and available treatment strategies. Nasal skin lesions were classified as benign, premalignant, or malignant. Read More

    Utility of Direct Immunofluorescence Studies in Subclassification of Autoimmune Sub-Epidermal Bullous Diseases: A 2-Year Study in a Tertiary Care Hospital.
    Turk Patoloji Derg 2016 ;32(2):91-8
    Department of Pathology Bharati Vidyapeeth Deemed University Medical College and Hospital, SANGLI, INDIA.
    Objective: Sub-epidermal bullous disorders belong to immunobullous diseases which develop as a result of autoantibody action against epidermal basement membrane proteins. Clinically, they are tense bullae and do not rupture easily. They are classified into various forms based on histopathology and direct immunofluorescence patterns. Read More

    Periodic Acid-Schiff Staining Parallels the Immunoreactivity Seen By Direct Immunofluorescence in Autoimmune Skin Diseases.
    N Am J Med Sci 2016 Mar;8(3):151-5
    Department of Dermatopathology, Georgia Dermatopathology Associates, Atlanta, Georgia, USA.
    Background: In many countries and laboratories, techniques such as direct immunofluorescence (DIF) are not available for the diagnosis of skin diseases. Thus, these laboratories are limited in the full diagnoses of autoimmune skin diseases, vasculitis, and rheumatologic diseases. In our experience with these diseases and the patient's skin biopsies, we have noted a positive correlation between periodic acid-Schiff (PAS) staining and immunofluorescence patterns; however, these were just empiric observations. Read More

    Neonatal Autoimmune Blistering Disease: A Systematic Review.
    Pediatr Dermatol 2016 Jul 18;33(4):367-74. Epub 2016 Apr 18.
    Department of Dermatology, St. George Hospital, Sydney, New South Wales, Australia.
    We aimed to better understand the pathogenesis, clinical features, prognosis, and treatment of neonatal autoimmune blistering diseases (AIBDs). We searched Medline, Embase, PubMed, Latin American and Caribbean Health Sciences Literature, and reference lists of identified articles. Inclusion criteria were articles published from 1946 to December 2014 in any language. Read More

    Altered expression of keratin 14 in lesional epidermis of autoimmune skin diseases.
    Int J Dermatol 2016 Jun 6;55(6):620-8. Epub 2015 Nov 6.
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany.
    Background: Keratin 14 (K14) is an intermediate filament protein that is mainly expressed in the basal layer of healthy stratified epithelia. K14 has been identified as an autoantigen in the autoimmune-mediated skin disease of Scurfy mice and patients with the "immune dysregulation polyendocrinopathy, enteropathy, and X-linked" syndrome.

    Objectives: To examine whether K14 is a target protein in autoimmune skin diseases (ASD), we analyzed the expression pattern of K14 in lesional skin of patients with lichen ruber, cutaneous lupus erythematosus, dermatomyositis, graft-versus-host disease, psoriasis, and pemphigus vulgaris, and evaluated the reactivity of patient sera with recombinantly expressed and epidermis-derived K14. Read More

    Retrospective Study on Autoimmune Blistering Disease in Paediatric Patients.
    Pediatr Dermatol 2015 Nov-Dec;32(6):845-52. Epub 2015 Sep 22.
    Division of Dermatology, National University Hospital, Singapore, Singapore.
    Background: Autoimmune blistering diseases (AIBDs) are rare in children and their prevalence in Singapore is unclear. We aimed to investigate the clinical and immunopathologic characteristics of children diagnosed with AIBDs in Singapore.

    Materials And Methods: The clinical and histology databases at the National Skin Centre in Singapore were searched to identify patients younger than 18 years old diagnosed with an AIBD from January 1, 1998, through December 31, 2012. Read More

    Two cases of annular erythema without bullous lesions by autoimmune blistering diseases.
    Mod Rheumatol 2018 Jan 19;28(1):200-202. Epub 2015 Oct 19.
    a Department of Dermatology , Shiga University of Medical Science , Setatsukinowa , Otsu , Shiga , Japan.
    Although annular erythema is usually observed as one of the cutaneous manifestations of Sjögren's syndrome or subacute cutaneous lupus erythematosus, autoimmune blistering diseases also present with annular erythema. However, bullous lesions are not always found, and there is a rare type without bullous lesions. We present two cases of autoimmune blistering diseases showing annular erythema without bullous lesions. Read More

    Guanine polynucleotides are self-antigens for human natural autoantibodies and are significantly reduced in the human genome.
    Immunology 2015 Nov 7;146(3):401-10. Epub 2015 Sep 7.
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
    In the course of investigating anti-DNA autoantibodies, we examined IgM and IgG antibodies to poly-G and other oligonucleotides in the sera of healthy persons and those diagnosed with systemic lupus erythematosus (SLE), scleroderma (SSc), or pemphigus vulgaris (PV); we used an antigen microarray and informatic analysis. We now report that all of the 135 humans studied, irrespective of health or autoimmune disease, manifested relatively high amounts of IgG antibodies binding to the 20-mer G oligonucleotide (G20); no participants entirely lacked this reactivity. IgG antibodies to homo-nucleotides A20, C20 or T20 were present only in the sera of SLE patients who were positive for antibodies to dsDNA. Read More

    Evolutionary medicine and bone loss in chronic inflammatory diseases--A theory of inflammation-related osteopenia.
    Semin Arthritis Rheum 2015 Oct 30;45(2):220-8. Epub 2015 Apr 30.
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA.
    Objective: Bone loss is typical in chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, ankylosing spondylitis, systemic lupus erythematosus, multiple sclerosis, inflammatory bowel diseases, pemphigus vulgaris, and others. It is also typical in transplantation-related inflammation and during the process of aging. While we recognized that bone loss is tightly linked to immune system activation or inflamm-aging in the form of acute, chronic active, or chronic smoldering inflammation, bone loss is typically discussed to be an "accident of inflammation. Read More

    Allelic and copy-number variations of FcγRs affect granulocyte function and susceptibility for autoimmune blistering diseases.
    J Autoimmun 2015 Jul 29;61:36-44. Epub 2015 May 29.
    Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany. Electronic address:
    Low-affinity Fcγ receptors (FcγR) bridge innate and adaptive immune responses. In many autoimmune diseases, these receptors act as key mediators of the pathogenic effects of autoantibodies. Genes encoding FcγR exhibit frequent variations in sequence and gene copy number that influence their functional properties. Read More

    Role of direct immunofluorescence in dermatological disorders.
    Indian Dermatol Online J 2015 May-Jun;6(3):172-80
    Department of Dermatology, M. S. Ramaiah Medical College and Hospital, Bengaluru, Karnataka, India.
    Background: Direct immunofluorescence (DIF) test for tissue-bound autoantibodies, has been found to be of value in the diagnosis of several dermatological disorders. The location and pattern of deposition of immunoreactants helps in classifying various immune-mediated diseases.

    Aims And Objectives: The aim of this study was to analyze the concordance between the clinical, histopathological and DIF diagnosis in bullous and nonbullous lesions of the skin, and thus determine the impact of immunofluorescence on diagnosis. Read More

    Extracorporeal photopheresis for the treatment of autoimmune diseases.
    Transfus Apher Sci 2015 Apr 16;52(2):171-82. Epub 2015 Feb 16.
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
    The immune system is tasked with the unique challenge of recognizing foreign pathogens and damaged cells while at the same time preserving and protecting the integrity of "self". When this process fails, severe consequences including cancer and autoimmunity are the end result. Current therapies aimed at treating autoimmune disorders result in generalized immunosuppression and place the patient at increased risk for infection and malignancy. Read More

    Bullous systemic lupus erythematosus associated with esophagitis dissecans superficialis.
    Case Rep Rheumatol 2015 2;2015:930683. Epub 2015 Mar 2.
    Department of Medicine, Interfaith Medical Center, Brooklyn, NY 11213, USA.
    Bullous systemic lupus erythematosus is one of the rare autoantibody mediated skin manifestation of systemic lupus erythematosus (SLE) demonstrating subepidermal blistering with neutrophilic infiltrate histologically. We present a case of a 40-year-old Hispanic female who presented with a several months' history of multiple blistering pruritic skin lesions involving the face and trunk, a photosensitive rash over the face and neck, swelling of the right neck lymph node, and joint pain involving her elbows and wrist. Her malady was diagnosed as bullous systemic lupus erythematosus based on the immunological workup and biopsy of her skin lesions. Read More

    Pemphigus and associated comorbidities: a cross-sectional study.
    Clin Exp Dermatol 2015 Aug 18;40(6):593-9. Epub 2015 Mar 18.
    Division of Dermatology, ON, Canada.
    Background: Pemphigus is a rare autoimmune blistering disease, reported to be associated with other coexisting and autoimmune diseases, including thyroid diseases, rheumatoid arthritis, alopecia areata, vitiligo, systemic lupus erythematosus, scleroderma and rare entities such as myasthenia gravis.

    Aim: To identify and describe patients with pemphigus with a diagnosed comorbidity, and to quantify the risk of additional comorbidities.

    Methods: This was a cross-sectional study of patients with pemphigus treated at a tertiary referral centre. Read More

    [Cormorbidity in multiple sclerosis and its therapeutic approach].
    Med Clin (Barc) 2014 Dec;143 Suppl 3:13-8
    Unitat d'Esclerosi Múltiple, Hospital Universitari i Politècnic La Fe, València, España. Electronic address:
    Multiple sclerosis (MS) is a long-term chronic disease, in which intercurrent processes develop three times more frequently in affected individuals than in persons without MS. Knowledge of the comorbidity of MS, its definition and measurement (Charlson index) improves patient management. Acting on comorbid conditions delays the progression of disability, which is intimately linked to the number of concurrent processes and with health states and habits. Read More

    Complement system in dermatological diseases - fire under the skin.
    Front Med (Lausanne) 2015 29;2. Epub 2015 Jan 29.
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki , Helsinki , Finland ; Huslab, Helsinki University Central Hospital , Helsinki , Finland ; Research Programs Unit, Immunobiology, University of Helsinki , Helsinki , Finland.
    The complement system plays a key role in several dermatological diseases. Overactivation, deficiency, or abnormality of the control proteins are often related to a skin disease. Autoimmune mechanisms with autoantibodies and a cytotoxic effect of the complement membrane attack complex on epidermal or vascular cells can cause direct tissue damage and inflammation, e. Read More

    Dermatologic disorders in 118 patients with autoimmune (immunoglobulin G4-related) pancreatitis: a retrospective cohort analysis.
    Am J Clin Dermatol 2015 Apr;16(2):125-30
    Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
    Background: Autoimmune pancreatitis is the prototypical manifestation of immunoglobulin G4-related disease, a fibroinflammatory syndrome that can affect virtually any organ. Rarely, skin involvement has been reported in immunoglobulin G4-related disease. Isolated case reports have described other distinct associated dermatoses. Read More

    Immune-mediated diseases: what can be found in the oral cavity?
    Int J Dermatol 2015 Mar 16;54(3):258-70. Epub 2014 Dec 16.
    Department of Stomatology III, Faculty of Odontology, Complutense University of Madrid, Madrid, Spain.
    Immune-mediated diseases frequently affect oral mucosa, which may often be the first site of clinical manifestation. In this review, we describe the most important oral lesions related to inflammatory disorders and present their management and novel therapies. The review is based on an open PubMed literature search from 1980 to 2012 with relevant keywords. Read More

    B cell epitope spreading: mechanisms and contribution to autoimmune diseases.
    Immunol Lett 2015 Jan 20;163(1):56-68. Epub 2014 Nov 20.
    Brigham Young University, Department of Microbiology and Molecular Biology, Provo, UT 84602, United States. Electronic address:
    While a variety of factors act to trigger or initiate autoimmune diseases, the process of epitope spreading is an important contributor in their development. Epitope spreading is a diversification of the epitopes recognized by the immune system. This process happens to both T and B cells, with this review focusing on B cells. Read More

    Identification of a new disease cluster of pemphigus vulgaris with autoimmune thyroid disease, rheumatoid arthritis and type I diabetes.
    Br J Dermatol 2015 Mar 15;172(3):729-38. Epub 2015 Feb 15.
    Department of Dermatology, University at Buffalo, 875 Ellicott Street, 6082 Clinical and Translational Research Center, Buffalo, NY, U.S.A.
    Background: Pemphigus vulgaris (PV) is a potentially fatal autoimmune blistering skin disease. It is known that individuals with autoimmune diseases such as PV, as well as their family members, are at increased risk of developing other autoimmune diseases. However, it is unknown whether there are specific autoimmune diseases that cluster with PV. Read More

    Pemphigus erythematosus relapse associated with atorvastatin intake.
    Drug Des Devel Ther 2014 18;8:1463-5. Epub 2014 Sep 18.
    Department of Dermatology, AORN "A Cardarelli", Naples, Italy.
    Statins, also known as 3-hydroxy-3-methylglutaril-CoA reductase inhibitors, are well-tolerated drugs used for prevention of atherosclerosis and cardiovascular events. Although they are generally considered safe, some serious adverse effects, such as myositis, myopathy, and rhabdomyolysis can rarely occur. Furthermore, recent data from long-term follow-up on patients who have been taking statins for a long period of time suggest that prolonged exposure to statins may trigger autoimmune reactions. Read More

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