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    103 results match your criteria Pemphigus Drug-Induced

    1 OF 3

    Pemphigus trigger factors: special focus on pemphigus vulgaris and pemphigus foliaceus.
    Arch Dermatol Res 2018 Mar 6;310(2):95-106. Epub 2017 Nov 6.
    Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Pemphigus is a general term for a rare group of autoimmune diseases which result in the formation of blisters on the skin and oral cavity. Although there is no way to prevent autoimmune diseases, some factors may trigger pemphigus initiation in susceptible individuals or be exacerbated in affected patients. Recognition of these triggers, based on the latest studies and experiences is essential and should be updated every few years. Read More

    Acta Clin Croat 2016 Jun;55(2):334-7
    A 70-year-old patient was admitted to the Department of Oral Medicine for multiple oral ulcerations on the left buccal mucosa, around 0.5 cm in diameter, as well as on the gingiva. Otherwise, the patient suffered from chronic lymphocytic leukemia, hypogammaglobulinemia, chronic renal insufficiency, with complete afunction of the right kidney, asthma, hypertension, gastritis and prostate hyperplasia. Read More

    A retrospective study of antihypertensives in pemphigus: a still unchartered odyssey particularly between thiols, amides and phenols.
    Arch Med Sci 2015 Oct;11(5):1021-7
    Cutaneous Histopathology and Immunopathology Section, Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
    Introduction: Autoimmune pemphigus diseases comprise several entities with serious prognoses, including the pemphigus vulgaris (PV) group and pemphigus foliaceus (PF) group. Antihypertensives are suspected to be one of the factors triggering/sustaining pemphigus. Here, the data of pemphigus patients regarding arterial hypertension (AH) and taking potentially noxious drugs were statistically analyzed in a setting of a Polish university dermatology department. Read More

    Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent.
    An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):51-4
    Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, BR.
    Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids include, among others, dapsone. Read More

    Drug-induced acute pancreatitis: a rare manifestation of an incomplete "dapsone syndrome".
    Indian J Pharmacol 2014 Jul-Aug;46(4):455-7
    Department of Medicine, Assam Medical College, Dibrugarh, Assam, India.
    Drug-induced acute pancreatitis (AP) is under-reported, and a large number of drugs are listed as offenders, but are often overlooked. Knowledge about the possible association of medications in causing AP is important, and needs a high index of suspicion, especially with drugs that have been reported to be the etiology only rarely. Dapsone, a commonly used drug, can cause various hypersensitivity reactions including AP collectively called "dapsone syndrome. Read More

    Severe drug-induced dermatoses.
    Semin Cutan Med Surg 2014 Mar;33(1):49-58
    Department of Dermatology, University of California San Francisco, CA USA. Email:
    A variety of common dermatoses are known to have drug-induced variants. This article discusses the clinical presentation, time frames, reported culprit medications, pathophysiology and management of drug-induced lupus, cutaneous vasculitis, pemphigus, pemphigoid, linear IgA bullous dermatosis, Sweet's syndrome, erythema nodosum, pyoderma gangrenosum, pseudolymphoma, lichen planus, and psoriasis. Read More

    Clinical and immunological profiles in 17 Japanese patients with drug-induced pemphigus studied at Kurume University.
    Br J Dermatol 2014 Sep 27;171(3):544-53. Epub 2014 Aug 27.
    Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.
    Background: Drug-induced pemphigus (DIP) shows clinical, histopathological and immunological features of pemphigus. However, little is known about immunological profiles in DIP.

    Objectives: To characterize clinical and immunological profiles in patients with DIP. Read More

    Clinical and cytologic features of antibiotic-resistant acute paronychia.
    J Am Acad Dermatol 2014 Jan;70(1):120-6.e1
    Department of Dermatology, Second University of Naples, Naples, Italy.
    Background: Acute paronychia usually is treated as a bacterial infection, but antibiotic-resistant acute paronychia may be caused by other infectious and noninfectious problems.

    Objective: We sought to describe the clinical, etiologic, cytologic, and therapeutic features of antibiotic-resistant acute paronychia.

    Methods: A retrospective review of medical records and cytology was performed in 58 patients (age, 1 month-91 years; 36 children and adolescents [62%] and 22 adults [38%]) who had antibiotic-resistant acute paronychias. Read More

    [D-penicillamine-induced pemphigus: changes in anti-32-2B immunostaining patterns].
    Ann Dermatol Venereol 2013 Aug-Sep;140(8-9):531-4. Epub 2013 May 21.
    Service de dermatologie, université François-Rabelais, CHRU, 37044 Tours cedex 9, France.
    Background: It has been reported that D-penicillamine causes pemphigus that is typically superficial. Immunostaining with monoclonal anti-32-2B antibody targeting desmoglein 1 and 3 can help differentiate between drug-induced and classical auto-immune pemphigus. Absence of specific staining militates in favour of drug-induced pemphigus whilst positive staining suggests an auto-immune aetiology that is ongoing despite discontinuation of drug therapy. Read More

    Oral bullous eruption after taking lisinopril--case report and literature review.
    Wien Klin Wochenschr 2013 Jul 21;125(13-14):408-11. Epub 2013 Jun 21.
    Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.
    Drug-induced lesions of oral mucosa are well-established side effect of different commonly used drugs. A female patient under treatment for hypertension with an angiotensin-converting enzyme inhibitor (ACE inhibitor), lisinopril, developed blisters and ulcerations on oral mucosa 3 weeks after lisinopril intake. Due to clinical finding drug-induced pemphigus was considered. Read More

    Alemtuzumab is effective against severe chronic lymphocytic leukaemia-associated paraneoplastic pemphigus.
    Br J Dermatol 2013 Aug;169(2):469-72
    Department of Haematology, Aarhus University Hospital, Aarhus, Denmark.
    Alemtuzumab (ALZ) is a monoclonal antibody used in the treatment of a variety of lymphoproliferative diseases, primarily chronic lymphocytic leukaemia (CLL). Paraneoplastic pemphigus (PNP) is a severe mucocutaneous disease, which can occur in association with B-cell malignancies. A correct diagnosis of PNP relies on distinct clinical and histopathological features, and the demonstration, by direct immunofluorescence, of intercellular and basement membrane IgG deposits in the affected tissue. Read More

    Toxic epidermal necrolysis.
    Curr Drug Saf 2012 Nov;7(5):332-8
    Department of Dermatology, Besançon University Hospital, France.
    Toxic epidermal necrolysis (TEN) is a severe mucocutaneous drug-induced syndrome that causes massive keratinocyte apoptosis and therefore hydro-electrolytic disorders and systemic infection. TEN approximately affects one to two cases per million per year. Mortality rate may reach thirty percent of cases. Read More

    Toxic Epidermal Necrolysis.
    Curr Drug Saf 2013 Feb 1. Epub 2013 Feb 1.
    Department of Dermatology, Besançon University Hospital, France.
    Toxic epidermal necrolysis (TEN) is a severe mucocutaneous drug-induced syndrome that causes massive keratinocyte apoptosis and therefore hydro-electrolytic disorders and systemic infection. TEN approximately affects one to two cases per million per year. Mortality rate may reach thirty percent of cases. Read More

    Pemphigus Vulgaris Associated with Rheumatoid Arthritis in a Patient not Taking Penicillamine.
    J Dent Res Dent Clin Dent Prospects 2012 13;6(1):33-5. Epub 2012 Mar 13.
    Assistant Professor, Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
    D-penicillamine is one of the disease-modifying anti-rheumatic drugs (DMARDs). Drug-induced pemphigus is not fre-quently associated with D-penicillamine, and to date, the number of reported cases is about a hundred. Most reports of D-penicillamine-induced pemphigus vulgaris are in patients with rheumatoid arthritis. Read More

    Amoxicillin/clavulanic acid-induced pemphigus vulgaris: case report.
    Acta Dermatovenerol Croat 2012 ;20(2):108-11
    Department of Dermatology and Venereology, Second University of Naples, Naples, Italy.
    Drug-induced pemphigus is a well-established variety of pemphigus, presenting with clinical and histopathologic features identical to idiopathic form. Medical history plays a fundamental role in the diagnosis of drug-induced pemphigus. A large variety of drugs have been implicated in its pathogenesis and they may induce acantholysis via biochemical and/or immune mechanism. Read More

    Diagnosis and clinical features of pemphigus vulgaris.
    Immunol Allergy Clin North Am 2012 May;32(2):233-43, v-vi
    Department of Dermatology, Westmead Hospital, Westmead, Sydney, NSW, Australia.
    Autoimmune bullous diseases are associated with autoimmunity against structural components that maintain cell-cell and cell-matrix adhesion in the skin and mucous membranes. They include those where the skin blisters at the basement membrane zone and those where the skin blisters within the epidermis (pemphigus vulgaris, pemphigus foliaceus, and other subtypes of pemphigus). The variants of pemphigus are determined according to the level of intraepidermal split formation. Read More

    Shape and configuration of skin lesions: targetoid lesions.
    Clin Dermatol 2011 Sep-Oct;29(5):504-8
    Dermatology Unit, Kaplan Medical Center, 76100 Rechovot, Israel (affiliated to the Hebrew University-Hadassah Medical School, Jerusalem, Israel).
    What is probably the first description of targetoid or iris lesions, as they appear in erythema multiforme (EM), can be found in Thomas Bateman's 1836 textbook "Practical Synopsis of Cutaneous Diseases According to the Arrangement of Dr. Willan." EM was initially described by Bateman and later by von Hebra as an acute self-limiting skin disease, symmetrically distributed on the extremities with typical concentric "targetoid" or "iris" lesions, and often recurrent. Read More

    Analysis of 6 cases of drug-induced pemphigus.
    Eur J Dermatol 2011 Sep-Oct;21(5):696-9
    Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing, China.
    Objectives: To study clinical and laboratory characteristics of drug-induced pemphigus.

    Methods: Using direct immunofluorescence (IF), indirect IF, ELISA and immunoblotting to characterize 6 patients with drug-induced pemphigus (DIP) and compared them with 20 cases of idiopathic pemphigus.

    Results: All the 6 cases of DIP showed obvious itching (100%) and no damage to the oral mucosa. Read More

    Drug-induced pemphigus.
    Clin Dermatol 2011 Jul-Aug;29(4):455-7
    Department of Dermatology, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, 6 Weizmann Street, Tel-Aviv University, Tel Aviv 64239, Israel.
    Pemphigus is an autoimmune bullous disease that may be influenced by genetic and exogenous factors. Drugs are a leading cause of pemphigus. There is a need for a thorough history taking so as to find the culprit medication. Read More

    Autoimmune blistering diseases of the skin.
    Autoimmun Rev 2012 Jan 27;11(3):226-30. Epub 2011 May 27.
    Department of Dermatology, University of Erlangen-Nuremberg, Germany.
    Autoimmune skin diseases represent a heterogeneous group of disorders with grossly diverging clinical manifestations but partly shared underlying immunological mechanisms. They may affect the skin as an isolated organ or among systemic diseases. In addition unspecific cutaneous symptoms or drug-induced unwanted effects can be seen and have to be carefully dissected from an exacerbations of the underlying disease. Read More

    Diagnosis and clinical features of pemphigus vulgaris.
    Dermatol Clin 2011 Jul;29(3):373-80, vii
    Department of Dermatology, Westmead Hospital, Westmead, Sydney, NSW, Australia.
    Autoimmune bullous diseases are associated with autoimmunity against structural components that maintain cell-cell and cell-matrix adhesion in the skin and mucous membranes. They include those where the skin blisters at the basement membrane zone and those where the skin blisters within the epidermis (pemphigus vulgaris, pemphigus foliaceus, and other subtypes of pemphigus). The variants of pemphigus are determined according to the level of intraepidermal split formation. Read More

    Autoimmune bullous skin diseases occurring under anti-tumor necrosis factor therapy: two case reports.
    Dermatology 2010 ;221(3):201-5
    Department of Dermatology and Venereology, Hôpital Cochin, Paris, France.
    Background: Anti-tumor necrosis factor (TNF) agents are increasingly being used for a rapidly expanding number of rheumatic and systemic diseases. As a result of this use, and of the longer follow-up periods of treatment, there are a growing number of reports of the development of autoimmune processes related to anti-TNF agents. The use of anti-TNF agents has been associated with more and more cases of autoimmune diseases, principally cutaneous vasculitis, lupus-like syndrome, systemic lupus erythematosus and interstitial lung disease. Read More

    A prospective analysis of anti-desmoglein antibody profiles in patients with rheumatoid arthritis treated with thiol compounds.
    J Dermatol Sci 2010 Sep 30;59(3):170-5. Epub 2010 Jun 30.
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry Pharmaceutical Sciences, Kita-ku, Okayama 700-8558, Japan.
    Background: Drug-induced pemphigus is mainly caused by drugs containing sulfhydryl (thiol) groups in their molecules.

    Objectives: To understand the serial alteration of anti-desmoglein (Dsg) antibody profile in patients with rheumatoid arthritis (RA) receiving thiol compounds.

    Methods: Anti-Dsg1 or -Dsg3 antibodies were analysed twice in a 1. Read More

    The patient with recurrent oral ulceration.
    Aust Dent J 2010 Jun;55 Suppl 1:14-22
    Dorevitch Pathology, Heidelberg, Victoria.
    This paper discusses the range of recurrent oral ulceration which affects the oral mucosa. Types of ulceration covered in this paper include traumatic, infective, aphthous, ulceration related to the oral dermatoses, drug-induced, ulceration as a manifestation of systemic disease and ulceration indicating malignancy. Aspects of the aetiology, diagnosis and management of common oral recurrent ulcerative conditions are reviewed from a clinical perspective as an aid to practising dentists. Read More

    ACE inhibitors can induce circulating antibodies directed to antigens of the superficial epidermal cells.
    Arch Dermatol Res 2011 Jul 20;303(5):327-32. Epub 2010 Jun 20.
    Di.S.E.M. Section of Dermatology, University of Genoa, Viale Benedetto XV, Genoa, Italy.
    Drug-induced pemphigus has been reported in patients receiving angiotensin-converting enzyme inhibitors. The aim of this work was to study a group of hypertensive patients without skin diseases treated with angiotensin-converting enzyme (ACE) Inhibitors (I), to verify the presence of serum circulating anti-antibodies. The indirect immunofluorescence showed that 33 sera (52. Read More

    Immunogenetics of drug-induced skin blistering disorders. Part II: synthesis.
    Pharmacogenomics 2009 May;10(5):779-816
    School of Biological Sciences, University of Reading, Whiteknights, Reading, UK.
    The overall immunopathogenesis relevant to a large series of disorders caused by a drug or its associated hyperimmune condition is discussed based upon examining the genetics of severe drug-induced bullous skin problems (sporadic idiosyncratic adverse events including Stevens-Johnson syndrome and Toxic epidermal necrolysis). New results from an exemplar study on shared precipitating and perpetuating inner causes with other related disease phenotypes including aphtous stomatitis, Behçets, erythema multiforme, Hashimoto's thyroiditis, pemphigus, periodic fevers, Sweet's syndrome and drug-induced multisystem hypersensitivity are presented. A call for a collaborative, wider demographic profiling and deeper immunotyping in suggested future work is made. Read More

    Non-infectious ulcerating oral mucous membrane diseases.
    J Dtsch Dermatol Ges 2009 Mar;7(3):242-57
    Department of Dermatology, Venerology and Allergology/Immunological Center, Dessau Medical Center, Germany.
    Non-infectious ulcerative oral mucous membrane diseases are difficult to separate at first glance: they can appear as aphthous, bullous, lichenoid, drug-induced or toxic-irritative reactions. The overall considerations of history, localization of lesions, clinical and histological features, as well as direct and indirect immunofluorescence examination are required for the correct diagnosis. Some disorders start preferably at the oral mucosa, like pemphigus vulgaris and Adamantiades-Behçet disease, while others, such as cicatricial pemphigoid and habitual aphthosis generally are confined to the mucous membranes. Read More

    Immunostaining with antibodies to desmoglein provides the diagnosis of drug-induced pemphigus and allows prediction of outcome.
    Am J Clin Pathol 2008 Sep;130(3):369-74
    University François Rabelais, Laboratory Ultrasound Signal Instrumentation CNRS FRE 2448, Department of Dermatology, University Hospital Center of Tours, Tours, France.
    No tool is available to diagnose drug-induced pemphigus (DIP) and to predict its outcome after the withdrawal of the culprit drugs. This retrospective pemphigus case series study compared cutaneous/mucosal immunostaining of a monoclonal antibody directed toward desmogleins 1 and 3 (32-2B) in 37 patients with DIP and 56 patients with idiopathic pemphigus. There was a significant difference between the groups in terms of pruritus, superficial form, mucosal involvement, and circulating antibodies. Read More

    In vitro interferon-gamma release test in patients with drug-induced pemphigus.
    Isr Med Assoc J 2008 Jun;10(6):424-7
    Department of Dermatology, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
    Background: Drug-specific CD8+ TH1 lymphocytes have been found in the peripheral blood and involved skin of patients with drug-induced bullous exanthems.

    Objectives: To determine whether the interferon-gamma release test can identify culprit drugs in pemphigus patients.

    Methods: Clinical and laboratory workup for pemphigus was performed in 14 pemphigus vulgaris patients who had been exposed to drugs, and the IFN-gamma release test was conducted on their lymphocytes from heparinized venous blood cultured with medium, phytohemagglutinin and one of 32 drugs, or medium and phytohemagglutinin alone. Read More

    [Current differential diagnosis of hypereosinophilic syndrome].
    Med Pregl 2007 Nov-Dec;60(11-12):581-6
    Klinika za hematologiju, Klinicki centar Vojvodine, Novi Sad.
    Introduction: Hypereosinophilic syndrome (HES) is a group of idiopathic disorders associated with single or multiple organ system dysfunction. HES must be distinguished from reactive eosinophilia in parasitic infections, allergic diseases, and especially from hematological diseases of clonal origin.

    Reactive Eosinophilia Due To Infectious And Parasitic Diseases: Tissue helminth infections, especially toxocariasis, cause severe and long-standing hypereosinophilia. Read More

    Drug-induced skin, nail and hair disorders.
    Drug Saf 2007 ;30(11):1011-30
    University of Paris XII, Créteil, France.
    Drug eruptions are among the most common adverse drug reactions, affecting approximately 3% of hospitalised patients. Although the rate of severe cutaneous adverse reactions to medications is low, these reactions can affect anyone who takes medication, and can result in death or disability. Two general patterns can be distinguished, depending on the type of onset of these cutaneous adverse drug reactions: acute or chronic. Read More

    An erythrodermic variant of pemphigus foliaceus with puzzling histologic and immunopathologic features.
    J Cutan Med Surg 2007 Sep-Oct;11(5):179-84
    Department of Dermatology, University of Illinois at Chicago, Chicago, IL, USA.
    Background: Pemphigus foliaceus is an autoimmune blistering disorder that affects the skin owing to autoantibodies against desmoglein 1.

    Methods: We employed clinical, histologic, immunopathologic, and serum laboratory studies to investigate a case of an erythrodermic variant of pemphigus foliaceus in an elderly man following treatment with bisoprolol-hydrochlorothiazide.

    Results: Early histopathology revealed psoriasiform dermatitis, but later biopsies showed subcorneal and granular layer separation with neutrophilic infiltrate. Read More

    Suspected polymyxin B-induced pemphigus vulgaris in a dog.
    Vet Dermatol 2007 Jun;18(3):165-70
    Division of Companion Animal Studies, Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, Bristol BS40 5DU, UK.
    A case of pemphigus vulgaris (PV), putatively induced by topical application of polymyxin B ear drops, is described. A 3-year-old, female Tosa Inu, presented with acute onset swelling, blistering and ulceration of the pinnae, nostrils, lips and oral mucous membranes. The dog was depressed, febrile and anorexic. Read More

    [Adverse drug effects in the oral region].
    Tidsskr Nor Laegeforen 2006 May;126(10):1345-8
    Seksjon for odontologisk farmakologi og farmakoterapi, Universitetet i Oslo, Postboks 1057 Blindern, 0316 Oslo.
    Syphilis was previously termed "the great imitator" because so many of the signs and symptoms are indistinguishable from those of other diseases. This role has been taken over by drugs, and this also applies to adverse drug reactions in the oral region. Accordingly, a careful drug history, including identification of any prescription, over-the-counter, or herbal medicines used, may give an important clue to the differential diagnosis of oral diseases when the aetiology is not apparent. Read More

    A case of drug-induced hypersensitivity syndrome showing transient immunosuppression before viral reactivation during treatment for pemphigus foliaceus.
    Clin Exp Dermatol 2006 Jan;31(1):33-5
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
    Drug-induced hypersensitivity syndrome (DIHS) is one of the most severe drug adverse reactions, with characteristic biphasic symptoms. Reactivation of human herpesvirus-6 (HHV-6) is frequently observed, although the cause of DIHS is still unknown. A patient developed DIHS during treatment with diaminodiphenylsulphone for pemphigus foliaceus. Read More

    [Oral ulcers].
    Med Clin (Barc) 2005 Oct;125(15):590-7
    Departamento de Medicina Bucal y Periodoncia, Facultad de Odontología, Universidad Complutense de Madrid, Madrid, Spain.
    Ulcers commonly occur in the oral cavity, their main symptom being pain. There are different ways to classify oral ulcers. The most widely accepted form divides them into acute ulcers--sudden onset and short lasting--and chronic ulcers--insidious onset and long lasting. Read More

    Pemphigus vulgaris triggered by glibenclamide and cilazapril.
    Acta Dermatovenerol Croat 2005 ;13(3):153-5
    Department of Dermatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.
    A case of pemphigus triggered by glibenclamide and cilazapril is described. The suspicion of drug induction was confirmed in a laboratory study in which a pemphigus-like effect was induced by glibenclamide in cultured human skin explants. Withdrawal of the drugs and their replacement by hydrochlorothiazide and metformin resulted in subsidence of the lesions and no appearance of new lesions. Read More

    Decline of anti-desmoglein 1 IgG ELISA scores by withdrawal of D-penicillamine in drug-induced pemphigus foliaceus.
    Clin Exp Dermatol 2005 Jan;30(1):43-5
    Keio University School of Medicine, Department of Dermatology, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan.
    A case of pemphigus foliaceus arising during the administration of D-penicillamine was reported. A 72-year-old woman with systemic sclerosis developed flaccid vesicles and crusted erythema of the skin after administration of D-penicillamine for 1-year. She was positive for anti-desmoglein 1 IgG by ELISA. Read More

    Follicular non-Hodgkin's lymphoma with refractory paraneoplastic pemphigus: case report with review of novel treatment modalities.
    Leuk Lymphoma 2004 Nov;45(11):2327-32
    Department of Dermatology, University Medical Centre Nijmegen, Nijmegen, The Netherlands.
    In this paper a patient with a non-Hodgkin's lymphoma (NHL) and paraneoplastic pemphigus (PNP) is described. PNP is a very rare, painful mucocutaneous intraepithelial blistering disease associated with occult or confirmed malignancy. Patients with PNP show severe, progressive mucocutaneous disease with a high mortality rate, because of drug-induced infectious complications. Read More

    Management of autoimmune skin disorders in the elderly.
    Drugs Aging 2004 ;21(12):767-77
    Department of Dermatology, Addenbrooke's NHS Trust, Cambridge, UK.
    Senescence of the skin immunological system may explain why the elderly population has an increased susceptibility to certain autoimmune skin disorders. These disorders are characterised by the production of either antibodies that react with host tissue or immune effector T cells that are autoreactive. Bullous pemphigoid is the most common autoimmune blistering disease in the elderly. Read More

    Pemphigus vulgaris triggered by rifampin and emotional stress.
    Skinmed 2004 Sep-Oct;3(5):294
    Department of Dermatology, Tel Aviv Sourasky Medical Center,6 Weizmann Street, Tel Aviv 64239, Israel.
    A 56-year-old Jewish woman of Ashkenazi origin had a history of tuberculosis since the age of 1 year, contracted while she was in hiding in Poland during the Holocaust. She developed bronchiectasis in 1972 for which she was being treated 4 times a year for 1-month periods with 600 mg/d rifampin. During the Persian Gulf War in February 1991, a month after a rifampin treatment, she was admitted to the dermatology department with cutaneous and oral mucous eruptions. Read More

    Drug-induced lupus erythematosus.
    Clin Dermatol 2004 Mar-Apr;22(2):157-66
    Department of Dermatology and Venereology, Sofia Faculty of Medicine, Sofia, Bulgaria.
    Among the numerous idiopathic immune-mediated diseases that can be drug-induced, such as pemphigus, psoriasis, lichen, etc, drug-induced lupus is the most widely commented upon and investigated. The terms drug-induced lupus (DIL) and drug-induced lupus erythematosus (DILE) are preferred, but other ones are also used--drug-related lupus, lupus-like syndrome, and lupus erythematosus medicamentosus. This review discusses the general issues in DILE, such as pathogenic mechanisms, clinical forms, and diagnostic criteria, and provides more detailed information for some of the implicated drugs: minocycline, statins, terbinafine, etc. Read More

    Pemphigus foliaceus: an adverse reaction to lisinopril.
    J Dermatolog Treat 2004 Jan;15(1):60-2
    Department of Dermatology, Derriford Hospital, Plymouth, Devon, England.
    Lisinopril is an angiotensin converting enzyme inhibitor used in the treatment of cardiovascular disease. We report a case of pemphigus foliaceus in a 66-year-old male treated with lisinopril for hypertension and a previous myocardial infarction. The drug-induced variant of pemphigus is caused by a wide variety of drugs and is most frequently associated with captopril and penicillamine. Read More

    Successful treatment of a high-grade intraepithelial neoplasia with imiquimod, with vulvar pemphigus as a side effect.
    Eur J Obstet Gynecol Reprod Biol 2003 Aug;109(2):224-7
    Department of Obstetrics and Gynecology, Clínica Bella Médica, Partida Cap Negret 17, 03590 Altea, Spain.
    Imiquimod modulates the immune response, and is a new approach for treatment of papillomavirus-associated lesions, although it has not been approved for the treatment of intraepithelial neoplasia. We present a case of a patient treated with imiquimod on account of high-grade intraepithelial neoplasia in the vulva and other locations. The posterior biopsies confirm the absence of lesions but show drug-induced pemphigus as a side effect. Read More

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