120 results match your criteria Pemphigus Drug-Induced


Oroesophageal Pemphigus vulgaris Secondary to Lisinopril Use: A New Side Effect.

Cureus 2021 Apr 6;13(4):e14333. Epub 2021 Apr 6.

Gastroenterology, Allegheny Health Network, Pittsburgh, USA.

Pemphigoid diseases are a group of blistering autoimmune pathologies including pemphigus vulgaris (PV) and pemphigus foliaceous, which affect mucocutaneous tissues. Non-steroidal anti-inflammatory drugs, penicillamine, and angiotensin-converting enzyme inhibitors such as captopril and enalapril are associated with drug-induced pemphigoid. We present a case of lisinopril-associated PV which has not been previously reported. Read More

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Case Report: Complete and Fast Recovery From Severe COVID-19 in a Pemphigus Patient Treated With Rituximab.

Front Immunol 2021 16;12:665522. Epub 2021 Apr 16.

Molecular and Cell Biology Laboratory IDI-IRCCS, Rome, Italy.

COVID-19 is characterized by a severe pulmonary disease due to severe acute respiratory syndrome (SARS)-CoV-2 infection. For clinicians involved in the management of patients with chronic autoimmune diseases the risk linked to the conditions itself and to drug-induced immunosuppression during the COVID-19 pandemic is a major topic. Pemphigus is a rare autoimmune blistering disease (AIBD) of the skin and mucous membranes caused by autoantibodies to desmosomal components, desmoglein 1 and 3. Read More

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Intraepithelial autoimmune blistering dermatoses: Clinical features and diagnosis.

J Am Acad Dermatol 2021 Jun 5;84(6):1507-1519. Epub 2021 Mar 5.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

Intraepithelial autoimmune blistering dermatoses are a rare group of skin disorders characterized by the intraepithelial disruption of intercellular connections through the action of autoantibodies. The first article in this continuing medical education series explores the background, epidemiology, clinical features, and diagnostic criteria of each of the major intraepithelial autoimmune blistering dermatoses, including pemphigus foliaceus, pemphigus erythematosus, pemphigus herpetiformis, fogo selvagem, pemphigus vulgaris, pemphigus vegetans, drug-induced pemphigus, IgA pemphigus, IgG/IgA pemphigus, and paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome. Read More

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Drug-induced pemphigus: A systematic review of 170 patients.

Int Immunopharmacol 2021 Mar 5;92:107299. Epub 2021 Jan 5.

Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, 009821 Iran.

Pemphigus encompasses a rare heterogeneous group of autoimmune blistering diseases characterized by cutaneous and/or mucosal blistering. Multiple factors, such as some specific types of drugs, have been found to be involved in the induction of pemphigus. Here, we have designed a systematic review by searching PubMed/Medline and Embase databases to find the drugs, involved in pemphigus induction and exacerbation (updated on 19 August 2019). Read More

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Drug Induced Cutaneous Manifestations due to Treatment of Gastrointestinal Disorders.

Curr Drug Metab 2021 ;22(2):99-107

Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Cutaneous manifestations due to drugs used in the treatment of gastrointestinal disorders are multiple and common. Adequate diagnosis is of great importance, bearing in mind that the therapeutic regimen depends on its diagnosis. In this review, we provided an overview of the most common drug-induced skin lesions with a detailed explanation of the disease course, presentation and treatment, having in mind that in recent years, novel therapeutic modalities have been introduced in the treatment of various gastrointestinal disorders, and that incidence of cutaneous adverse reactions has been on the rise. Read More

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January 2021

Non infective bullous lesions: a diagnostic challenge in a minimally equipped centre- based solely on microscopic findings.

Afr Health Sci 2020 Jun;20(2):885-890

Pandit Deendayal Upadhyay Medical College.

Vesicobullous lesions of skin may occur in different forms of dermatosis, which include various inflammatory, infective, autoimmune, drug induced as well as genetic conditions. Autoimmune bullous lesions, may be fatal if not treated with appropriate agents. Bearing in mind, the morbidity of these diseases, it is important to establish a firm diagnosis. Read More

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Erythroderma: A clinicopathological study of 47 cases from 2018 to 2020.

Dermatol Ther 2020 11 10;33(6):e14342. Epub 2020 Oct 10.

Department of Dermatology and Venereology, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Erythroderma, or exfoliative dermatitis, is an inflammatory disorder characterized by erythema and scaling, affecting most of the skin surface. It may be a result of many different causes such as previous dermatoses (psoriasis, eczema, atopic dermatitis [AD], pityriasis rubra pilaris, and pemphigus foliaceous), drug reactions, malignancies (mycosis fungoides [MF], Sézary syndrome, adult T cell leukemia/lymphoma), infections, and idiopathic disorders. Regardless of the etiology, the clinical appearance of erythroderma is similar in all patients. Read More

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November 2020

Hydrochlorothiazide vs Venlafaxine: Drug-induced Bullous Pemphigoid.

Cureus 2019 Jun 25;11(6):e4999. Epub 2019 Jun 25.

Internal Medicine/ Hematology and Oncology, Ashland Bellefonte Cancer Center, Ashland, USA.

Pemphigoid group of dermatologic conditions is a group of autoimmune skin disorders resulting in blistering skin conditions. The two diseases that fall under this category are bullous pemphigoid and pemphigus vulgaris. While there are many similarities in these two disorders, there are numerous pathologic and biochemical differences which help us differentiate between these disorders. Read More

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Metoprolol-Induced Pemphigus-Like Reaction.

Clin Adv Periodontics 2019 03 28;9(1):24-28. Epub 2018 Sep 28.

Central Ohio Skin & Cancer, Inc., Westerville, OH.

Introduction: Pemphigus vulgaris (PV) is a relatively rare, potentially life-threatening autoimmune disease that, in most cases, has an unknown etiology. Medications for hypertension have been linked to the onset and exacerbation of PV-like symptoms. The diagnosis of medication-related PV can be challenging because it has an identical appearance to the clinical and histologic appearance of idiopathic PV and cases may not resolve after discontinuation of the drug. Read More

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Immunologic adverse reactions of β-blockers and the skin.

Exp Ther Med 2019 Aug 18;18(2):955-959. Epub 2019 Apr 18.

Department of Diabetic Foot Care, 'Prof. N. Paulescu' National Institute of Diabetes, 011233 Bucharest, Romania.

β-Blockers are a widely utilised class of medication. They have been in use for a variety of systemic disorders including hypertension, heart failure and intention tremors. Their use in dermatology has garnered growing interest with the discovery of their therapeutic effects in the treatment of haemangiomas, their potential positive effects in wound healing, Kaposi sarcoma, melanoma and pyogenic granuloma, and, more recently, pemphigus. Read More

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A review and guide to drug-associated oral adverse effects-Oral mucosal and lichenoid reactions. Part 2.

J Oral Pathol Med 2019 Aug 26;48(7):637-646. Epub 2019 Jun 26.

Melbourne Dental School, The University of Melbourne, Carlton, Victoria, Australia.

Dental practitioners and other health professionals commonly encounter and manage adverse medicine effects that manifest in the orofacial region. Numerous medicines are associated with a variety of oral adverse effects. However, due to lack of awareness and training, these side effects are not always associated with medicine use and are underreported to pharmacovigilance agencies by dentists and other health professionals. Read More

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Imatinib-induced IgA Pemphigus: Subcorneal Pustular Dermatosis Type.

Indian Dermatol Online J 2018 Sep-Oct;9(5):331-333

Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.

Imatinib mesylate, a tyrosine kinase inhibitor, is commonly used in the treatment of chronic myeloid leukemia. IgA pemphigus is a rare bullous dermatosis caused by IgA autoantibodies. Clinical manifestations include localized or generalized itchy blisters and pustules. Read More

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September 2018

Angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers induced pemphigus: A case series and literature review.

Dermatol Ther 2019 01 11;32(1):e12748. Epub 2018 Oct 11.

Pharmacology Unit, Department of Science of Health, Magna Graecia University, Catanzaro, Italy.

Pemphigus is a group of autoimmune diseases characterized by the formation of erosions and/or flaccid bullae of the skin and/or mucosae. The definition "drug-induced pemphigus" has been coined to indicate cases of pemphigus with clinical, histological and immunopathologic features similar to those of the idiopathic disease but induced by systemic ingestion or local use of some drugs. The present authors analyzed a case series of three case reports with clinical and pharmacological features compatible with the diagnosis of angiotensin converting enzyme inhibitors or angiotensin II receptor blocker drug-induced pemphigus. Read More

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January 2019

Lisinopril-associated bullous pemphigoid in an elderly woman: a case report of a rare adverse drug reaction.

Br J Clin Pharmacol 2018 11 29;84(11):2678-2682. Epub 2018 Aug 29.

Department of Family Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

An 87-year-old woman with a long-standing history of hypertension, hypothyroidism and diabetes presented to us with scaly and pruritic vesicles of an erythematous base and crusted surface of 2-month duration. They first appeared on her abdomen and gradually spread to her lower back, thighs, before spreading to her upper and lower limbs. Her lesions were non-painful, aggravated by sun exposure only, and sparing mucous membranes. Read More

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November 2018

Pemphigus trigger factors: special focus on pemphigus vulgaris and pemphigus foliaceus.

Arch Dermatol Res 2018 Mar 6;310(2):95-106. Epub 2017 Nov 6.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pemphigus is a general term for a rare group of autoimmune diseases which result in the formation of blisters on the skin and oral cavity. Although there is no way to prevent autoimmune diseases, some factors may trigger pemphigus initiation in susceptible individuals or be exacerbated in affected patients. Recognition of these triggers, based on the latest studies and experiences is essential and should be updated every few years. Read More

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DRUG-INDUCED ORAL ULCERATIONS: CASE REPORT.

Acta Clin Croat 2016 Jun;55(2):334-7

A 70-year-old patient was admitted to the Department of Oral Medicine for multiple oral ulcerations on the left buccal mucosa, around 0.5 cm in diameter, as well as on the gingiva. Otherwise, the patient suffered from chronic lymphocytic leukemia, hypogammaglobulinemia, chronic renal insufficiency, with complete afunction of the right kidney, asthma, hypertension, gastritis and prostate hyperplasia. Read More

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Non-drug-induced pemphigus foliaceus in a patient with rheumatoid arthritis.

Cutis 2016 Mar;97(3):E1-2

Department of Dermatology and Venereology, Hietzing Municipal Hospital, Vienna, Austria.

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A retrospective study of antihypertensives in pemphigus: a still unchartered odyssey particularly between thiols, amides and phenols.

Arch Med Sci 2015 Oct;11(5):1021-7

Cutaneous Histopathology and Immunopathology Section, Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

Introduction: Autoimmune pemphigus diseases comprise several entities with serious prognoses, including the pemphigus vulgaris (PV) group and pemphigus foliaceus (PF) group. Antihypertensives are suspected to be one of the factors triggering/sustaining pemphigus. Here, the data of pemphigus patients regarding arterial hypertension (AH) and taking potentially noxious drugs were statistically analyzed in a setting of a Polish university dermatology department. Read More

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October 2015

Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent.

An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):51-4

Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, BR.

Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids include, among others, dapsone. Read More

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January 2016

Drug-induced acute pancreatitis: a rare manifestation of an incomplete "dapsone syndrome".

Indian J Pharmacol 2014 Jul-Aug;46(4):455-7

Department of Medicine, Assam Medical College, Dibrugarh, Assam, India.

Drug-induced acute pancreatitis (AP) is under-reported, and a large number of drugs are listed as offenders, but are often overlooked. Knowledge about the possible association of medications in causing AP is important, and needs a high index of suspicion, especially with drugs that have been reported to be the etiology only rarely. Dapsone, a commonly used drug, can cause various hypersensitivity reactions including AP collectively called "dapsone syndrome. Read More

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Severe drug-induced dermatoses.

Semin Cutan Med Surg 2014 Mar;33(1):49-58

Department of Dermatology, University of California San Francisco, CA USA. Email:

A variety of common dermatoses are known to have drug-induced variants. This article discusses the clinical presentation, time frames, reported culprit medications, pathophysiology and management of drug-induced lupus, cutaneous vasculitis, pemphigus, pemphigoid, linear IgA bullous dermatosis, Sweet's syndrome, erythema nodosum, pyoderma gangrenosum, pseudolymphoma, lichen planus, and psoriasis. Read More

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Clinical and immunological profiles in 17 Japanese patients with drug-induced pemphigus studied at Kurume University.

Br J Dermatol 2014 Sep 27;171(3):544-53. Epub 2014 Aug 27.

Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.

Background: Drug-induced pemphigus (DIP) shows clinical, histopathological and immunological features of pemphigus. However, little is known about immunological profiles in DIP.

Objectives: To characterize clinical and immunological profiles in patients with DIP. Read More

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September 2014

Clinical and cytologic features of antibiotic-resistant acute paronychia.

J Am Acad Dermatol 2014 Jan;70(1):120-6.e1

Department of Dermatology, Second University of Naples, Naples, Italy.

Background: Acute paronychia usually is treated as a bacterial infection, but antibiotic-resistant acute paronychia may be caused by other infectious and noninfectious problems.

Objective: We sought to describe the clinical, etiologic, cytologic, and therapeutic features of antibiotic-resistant acute paronychia.

Methods: A retrospective review of medical records and cytology was performed in 58 patients (age, 1 month-91 years; 36 children and adolescents [62%] and 22 adults [38%]) who had antibiotic-resistant acute paronychias. Read More

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January 2014

[D-penicillamine-induced pemphigus: changes in anti-32-2B immunostaining patterns].

Ann Dermatol Venereol 2013 Aug-Sep;140(8-9):531-4. Epub 2013 May 21.

Service de dermatologie, université François-Rabelais, CHRU, 37044 Tours cedex 9, France.

Background: It has been reported that D-penicillamine causes pemphigus that is typically superficial. Immunostaining with monoclonal anti-32-2B antibody targeting desmoglein 1 and 3 can help differentiate between drug-induced and classical auto-immune pemphigus. Absence of specific staining militates in favour of drug-induced pemphigus whilst positive staining suggests an auto-immune aetiology that is ongoing despite discontinuation of drug therapy. Read More

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