9,999 results match your criteria Pemphigus Drug-Induced
Australas J Dermatol 2018 Dec 9. Epub 2018 Dec 9.
Department of Dermatology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.
Ann Anat 2018 Dec 7. Epub 2018 Dec 7.
Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Pettenkoferstr. 11, 80336 Munich, Germany. Electronic address:
Cell-Cell contacts are crucial for intercellular cohesion and formation of endothelial and epithelial barriers. Desmosomes are the adhesive contacts providing mechanical strength to epithelial intercellular adhesion and therefore are most abundant in tissues subjected to high mechanical stress such as the epidermis and heart muscle. Desmogleins (Dsg) besides intercellular adhesion serve as signalling hubs regulating cell behaviour. Read More
J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.
Loyola Univ Medical Center Dermatology, 321 N La Grange Rd, La, Grange Park, IL. Electronic address:
The incidence of zoster is increased in many autoimmune diseases. This study found a significantly increased zoster incidence in dermatomyositis and cutaneous lupus erythematosus compared with a control group.Physicians should be aware of this risk and consider administering the vaccine against zoster to these patients if not contraindicated. Read More
J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.
Loyola University Medical Center Dermatology, 321 N La Grange Rd, La Grange Park, IL. Electronic address:
•Hematologic malignancies have been reported sporadically in patients with pemphigus.•In the current study, significant associations were observed between pemphigus and chronic leukemia, multiple myeloma, and non-Hodgkin lymphoma.•Further research is needed to confirm these findings in other cohorts. Read More
Mol Plant Microbe Interact 2018 Dec 6. Epub 2018 Dec 6.
University of Toledo College of Natural Sciences and Mathematics, 385199, Department of Environmental Sciences, Toledo, Ohio, United States.
Insect galls are highly specialized structures arising from atypical development of plant tissue induced by insects. Galls provide the insect enhanced nutrition and protection against natural enemies and environmental stresses. Galls are essentially plant organs formed by an intimate biochemical interaction between the gall-inducing insect and its host-plant. Read More
Hautarzt 2018 Dec 5. Epub 2018 Dec 5.
Klinik für Dermatologie, Allergologie und Venerologie, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.
Autoimmmune bullous diseases are mediated by pathogenetically relevant autoantibodies against components of the epidermis and/or superficial mucous membranes (in pemphigus) and structural proteins of the dermal-epidermal junction (in pemphigoid diseases). Using immunoadsorption (IA), an already well-established procedure in cardiac and rheumatic disorders, antibodies can be removed from the plasma. At present, most data on the adjuvant use of IA in dermatology are derived from patients with severe and/or refractory pemphigus vulgaris or pemphigus foliaceus and also from patients with pemphigoid diseases. Read More
J Cell Biochem 2018 Dec 3. Epub 2018 Dec 3.
Department of Dermatology, The Second Hospital of Xi'an Jiaotong University, Xi'an, China.
Benign chronic familial pemphigus or Hailey-Hailey disease (HHD, OMIM 169600) is a rare, autosomal dominant blistering skin disorder characterized by suprabasal cell separation (acantholysis) of the epidermis. To date, the proteomic changes in skin lesions from HHD patients has not been reported yet. In this study, a sample of skin lesions from HHD patients was collected for isobaric tags for relative and absolute quantitation to analyze proteome changes compared with unaffected individuals. Read More
Arch Dermatol Res 2018 Dec 1. Epub 2018 Dec 1.
Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Vahdate-Eslami Square, Tehran, 11996, Iran.
During the last decade, successfully treatment of patients diagnosed with pemphigus vulgaris (PV) with rituximab (RTX) was reported by several authors. The present study has been designed to compare the clinical outcomes and RTX-related side effects between the two groups of early treated (≤ 6 months) and lately treated PV (> 6 months) patients with RTX. We did a retrospective study between Oct 2014 and Jun 2016 to compare the short-term efficacy and safety of RTX in PV diagnosed patients. Read More
Indian Dermatol Online J 2018 Nov-Dec;9(6):422-425
Department of Dermatology, Venereology, and Leprosy, Gandhi Medical College, Hyderabad, Telangana, India.
Background: Pemphigus disorders are a group of immunobullous diseases affecting skin and/or mucus membranes. Dexamethasone cyclophosphamide pulse (DCP)/dexamethasone only pulse (DOP) therapy has shown promising results in the management of pemphigus group of diseases in adults.
Aim: To evaluate the outcome of pulse therapy (PT) in pediatric cases diagnosed with pemphigus vulgaris (PV). Read More
Indian Dermatol Online J 2018 Nov-Dec;9(6):405-408
Department of Dermatology, Academy of Medical Sciences, Kannur, Kerala, India.
Context: Dexamethasone-immunosuppressant pulse therapy introduced by Pasricha . in 1981 as a treatment for long-term remission in pemphigus group of disorders has gained wide acceptance in many places, especially India. Since the overall duration of treatment is determined by the duration of phase 1 of the regime, identification of factors that influence phase 1 may be particularly helpful in addressing patient's concerns and apprehensions before initiation of treatment so that compliance can be improved. Read More
Indian Dermatol Online J 2018 Nov-Dec;9(6):367-372
Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India E-mail:
J Emerg Med 2018 Nov 29. Epub 2018 Nov 29.
Department of Oral Medicine, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania.
Australas J Dermatol 2018 Dec 4. Epub 2018 Dec 4.
Division of Immune-Mediated Skin Diseases, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Dermatol Pract Concept 2018 Oct 31;8(4):262-271. Epub 2018 Oct 31.
Autoimmune Bullous Disease Research Center, Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Background: Among exogenous etiologies, the critical role of microbial agents such as herpesviruses (HSV1/2) and cytomegalovirus (CMV) in triggering and flaring autoimmune conditions such as pemphigus vulgaris (PV) has been recently discovered.
Objectives: The present study aimed to investigate the plausible role of these viruses in the exacerbation of PV using serological and molecular methods.
Patients/methods: Sixty patients with PV (30 with relapse type and 30 with remission type) were recruited for the purpose of this case-control study. Read More
Dermatol Pract Concept 2018 Oct 31;8(4):252-261. Epub 2018 Oct 31.
School of Dentistry, University of Antioquia, Medellin, Colombia.
Background: We have described a variant of endemic pemphigus foliaceus (EPF) in El Bagre area known as pemphigus Abreu-Manu. Our previous study suggested that Colombian EPF seemed to react with various plakin family proteins, such as desmoplakins, envoplakin, periplakin BP230, MYZAP, ARVCF, p0071 as well as desmoglein 1.
Objectives: To explore whether patients affected by a new variant of endemic pemphigus foliaceus (El Bagre-EPF) demonstrated oral involvement. Read More
Front Med (Lausanne) 2018 9;5:315. Epub 2018 Nov 9.
Department of Dermatology, Venerology and Allergology, Allergy-Center-Charité, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Pemphigus foliaceus is an autoimmune skin disease mediated by autoantibodies directed against desmoglein-1 located in the upper epidermal layer. Rituximab, a monoclonal anit-CD20 antibody depleting b-cells, offers an effective treatment possibility for therapy-resistant pemphigus foliaceus. Here, we present the case of 55-year-old man who did not respond sufficiently to conventional treatment with prednisolone, azathioprine, and cyclophosphamide, but underwent almost complete remission after rituximab treatment. Read More
J Invest Dermatol 2018 Dec 2;138(12):2666-2668. Epub 2018 Jul 2.
Department of Dermatology, Rouen University Hospital, Rouen, France; Inserm U976 Saint Louis Hospital, Paris, France. Electronic address:
Front Med (Lausanne) 2018 8;5:306. Epub 2018 Nov 8.
Department of Dermatology, University of Pennsylvania, Philadelphia, PA, United States.
The 5th Scientific Conference of the International Pemphigus and Pemphigoid Foundation (IPPF), "Pemphigus and Pemphigoid: A New Era of Clinical and Translational Science" was held in Orlando, Florida, on May 15-16, 2018. Scientific sessions covered recent, ongoing, and future clinical trials in pemphigus and bullous pemphigoid, disease activity and quality of life instruments, and the IPPF Natural History Study. Furthermore, the meeting provided an opportunity to hear firsthand from patients, investigators, and industry about their experience enrolling for clinical trials. Read More
J Trace Elem Med Biol 2019 Jan 24;51:31-35. Epub 2018 Sep 24.
Laboratory of the Division of Dermatology, University Hospital, Ribeirão Preto Medical School, Avenida Bandeirantes, 3900, 14049-900, Ribeirão Preto, São Paulo, Brazil.
Pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are autoimmune bullous diseases; they are endemic in the northeastern region of the state of São Paulo, Southeastern Brazil. Patients' copper (Cu), zinc (Zn), and selenium (Se) metabolic deficiencies have already been associated with PV pathogenesis in the Middle East but not in Brazil. Lead (Pb), Cu, Zn, and Se concentrations were determined in whole blood or serum samples obtained from 56 PV patients, 62 PF patients, and 135 healthy controls from the endemic region and compared. Read More
Dermatol Clin 2019 Jan 1;37(1):65-71. Epub 2018 Nov 1.
Department of Dermatology, George Washington Medical Faculty Associates, 2150 Pennsylvania Avenue Northwest, Suite 2B-427, Washington, DC 20037, USA; Department of Dermatology, George Washington School of Medicine and Health Sciences, 2150 Pennsylvania Avenue Northwest, Suite 2B-427, Washington, DC 20037, USA. Electronic address:
Comorbidities affecting dermatologic patients are of significant importance to providers and highly relevant for appropriate patient counseling, screening practices, prevention, and treatment. This article seeks to highlight several of the newest findings in the literature regarding comorbidities associated with dermatologic diseases including atopic dermatitis, hidradenitis suppurativa, alopecia areata, chronic urticaria, and the pemphigus family of immunobullous diseases. Further investigation is needed for associations between atopic dermatitis and pancreatic cancer and pemphigus family diseases and chronic obstructive pulmonary disease in order to better characterize the strength of these associations and clinical relevance. Read More
Ann Acad Med Singapore 2018 Oct;47(10):429-430
National Skin Centre, Singapore.
Avicenna J Phytomed 2018 Nov-Dec;8(6):543-551
Shiraz Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.
Objective: L. fruit extract has been traditionally used in the treatment of pemphigus vulgaris (PV) lesions in Iran. The aim of this study was to determine the efficacy of fruit gel on healing time of PV lesions in a clinical setting. Read More
Front Med (Lausanne) 2018 2;5:296. Epub 2018 Nov 2.
Department of Dermatology, University of Lübeck, Lübeck, Germany.
Autoimmune skin blistering diseases (AIBD) are characterized by autoantibodies that are directed against structural proteins in the skin and adjacent mucous membranes. Some clinical signs are typical for a specific AIBD, however, correct diagnosis requires the detection of tissue-bound or circulating autoantibodies. The gold standard for diagnosis of AIBD is the detection of autoantibodies or complement component 3 by direct immunofluorescence (DIF) microscopy of a perilesional biopsy. Read More
Clin Pract Cases Emerg Med 2018 Nov 17;2(4):348-352. Epub 2018 Oct 17.
University of Maryland School of Medicine, Department of Emergency Medicine, Baltimore, Maryland.
A 61-year-old male with a recent diagnosis of pemphigus vulgaris was brought to the emergency department for altered mental status. He had recently started taking prednisone to manage his autoimmune disease and had a progressive decline in his mental status along with decreased oral intake. Evaluation revealed hyperosmolar hyperglycemic state (HHS) and occlusive arterial thrombosis, a rare but known complication of HHS. Read More
Eur J Dermatol 2018 Oct;28(5):713-715
Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou, China, Department of Medical Research, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan.
Postepy Dermatol Alergol 2018 Oct 19;35(5):532-534. Epub 2018 Jul 19.
Department of Dermatology and Immunodermatology, Medical University of Warsaw, Warsaw, Poland.
JAMA 2018 09;320(11):1200-1201
Department of Dermatology, University of Texas Health Science Center at Houston.
JAMA 2018 09;320(11):1200
Department of Dermatology, Suqian First Hospital, Suqian City, Jiangsu Province, China.
Dermatol Ther (Heidelb) 2018 Dec 10;8(4):653-663. Epub 2018 Nov 10.
Department of Neurology, Alzheimer Research Center Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Pemphigus is a bullous autoimmune disease that affects the skin and mucous membranes. It is very difficult to establish the etiology and the triggering factors that influence reactivations in pemphigus vulgaris (PV). The case of a 33-year-old male with chronic history of intranasal cocaine consumption is presented in this report. Read More
Int J Rheum Dis 2018 Nov 8. Epub 2018 Nov 8.
Department of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan.
Aim: Paraneoplastic pemphigus (PNP) is a mucocutaneous autoimmune disorder accompanied with a neoplasm. Castleman's disease (CD), although rare, is the most common cause of PNP in children. It can be life-threatening when pulmonary involvement occurs. Read More
Am J Dermatopathol 2018 Nov 1. Epub 2018 Nov 1.
Plastic Surgery, Hospital General Universitario de Valencia, Valencia, Spain.
Pemphigus foliaceus is an autoimmune bullous disease with autoantibodies against desmoglein 1. Case reports of pemphigus after surgery have also been described, which may simulate an infection of the surgical wound, a contact dermatitis, or even a tumor recurrence. Cytoimmunofluorescence can help to establish a rapid diagnosis. Read More
J Dtsch Dermatol Ges 2018 Nov;16(11):1339-1358
Department of Dermatology and Allergology, Marburg University Medical Center, Marburg, Germany.
Pathophysiologically, bullous autoimmune dermatoses are caused by autoantibodies directed against adhesion molecules or structural proteins of the skin and mucous membranes, clinically resulting in blister formation. Depending on the respective target proteins of the autoimmune response and their location in the skin, a distinction is made between intraepidermal (pemphigus disorders), junctional (pemphigoid disorders), and subepidermal (epidermolysis bullosa acquisita, dermatitis herpetiformis) autoimmune blistering diseases. The most common bullous autoimmune dermatosis, bullous pemphigoid is characterized by marked clinical variability and intense pruritus. Read More
Acta Dermatovenerol Croat 2018 Oct;26(3):226-232
Huijie Yuan, MD, Department of Dermatology Rui Jin Hospital, Shanghai Jiao Tong , University School of Medicine, 197 Ruijin Er Road, Shanghai 200025, China:
The aim of this study was to analyze the characteristics and the treatment for patients with psoriasis who presented with subsequent pemphigus after their treatment. A retrospective study of seven patients with psoriasis associated with pemphigus was performed, including the clinical assessment and treatments. The patients with a median age of 74 (range from 54 to 85) were significantly older than those in previously reported cases, where the median age was 58 (range from 15 to 77) (P<0. Read More
Head Neck Pathol 2018 Nov 2. Epub 2018 Nov 2.
Department of Anatomic Pathology, Naval Medical Center San Diego, San Diego, CA, USA.
Reticular oral lichen planus is a common clinical finding, often found incidentally on routine oral examination. Patients rarely complain of symptoms and the condition does not require treatment, as a result, biopsies and ancillary laboratory evaluation are seldom performed. We present a case of reticular oral lichen planus with a classic clinical presentation and characteristic histologic findings. Read More
Front Med (Lausanne) 2018 17;5:266. Epub 2018 Oct 17.
Department of Dermatology, Rambam Health Care Campus, Haifa, Israel.
The specificity and the predictive values of indirect immunofluorescence (IIF) in real-life settings is yet to be firmly established. The natural history of patients with false-positive results has not been sufficiently elucidated. The primary aim of the current study is to evaluate the diagnostic value of IIF analysis on monkey esophagus in pemphigus, utilizing a large cohort arising from the real-life experience of a tertiary referral center. Read More
G Ital Dermatol Venereol 2018 Oct 29. Epub 2018 Oct 29.
Dermatology Unit, Department of Physiopathology and Transplantation, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy -
Pemphigoid gestationis (PG), also known as herpes gestationis, is the prototypic pregnancy-associated autoimmune bullous disease (AIBD), but also the other AIBDs, notably pemphigus vulgaris, may begin or exacerbate during pregnancy. Although the increase in concentration of T and B regulatory cells makes pregnancy a state of increased immunologic tolerance toward the semiallogeneic fetal antigens, a prevalent T helper (Th) 2 profile, that is reported to be associated with pregnancy, may cause exacerbation of pemphigus and AIBDs in general during this period. Active disease may lead to stillbirth, spontaneous abortion, preterm pregnancy, low birthweight, and neonatal pemphigus. Read More
Br J Dermatol 2018 Oct 25. Epub 2018 Oct 25.
Departments of Dermatology, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, 35010, Spain.
Pemphigus is a group of rare autoimmune blistering diseases. There are two major types: pemphigus vulgaris (PV) and pemphigus foliaceus (PF). The incidence is low, and variable across studies (between 0,06 and 0,47 per 100·000 person-years in recent publications) . Read More
J Investig Allergol Clin Immunol 2018 Oct;28(5):347-348
Dermatology Unit, University of Padua, Padua, Italy.
Immunol Res 2018 Oct 18. Epub 2018 Oct 18.
Department of Quality Measurements and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel.
There is little consensus regarding the association between pemphigus and psoriasis. The aim of the current study is to synthesize existing data on the prevalence of psoriasis in patients with pemphigus and on the association between the two conditions. We performed a systematic review and meta-analysis of observational studies in Medline, Embase, and Web of Science (1900-2018). Read More
J Cutan Med Surg 2018 Nov/Dec;22(6):661
J Dermatol 2018 Dec 15;45(12):1396-1402. Epub 2018 Oct 15.
Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
The epidemiology of pemphigus varies among racial populations worldwide. Trends in the incidence of pemphigus have not been investigated based on the Korean National Health Insurance database. This study investigated the incidence and death rate of pemphigus with age using nationwide population data in South Korea. Read More
Br J Dermatol 2018 Oct;179(4):816-817
Department of Dermatology and Referral Centre for Autoimmune Blistering Diseases, Avicenne Hospital, Bobigny, France.
Br J Dermatol 2018 Oct;179(4):1012-1013
Department of Oral Medicine, Dental Institute, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, U.K.
J Eur Acad Dermatol Venereol 2018 Oct;32(10):1623-1624
Department of Dermatology, Philipps University, Marburg, Germany.
J Invest Dermatol 2018 Oct 6. Epub 2018 Oct 6.
Department of Dermatology, Rouen University Hospital, and INSERM U 1234, Centre de référence des maladies bulleuses autoimmunes, Normandie University, Rouen, France.
The Pemphigus Disease Area Index (PDAI) and Autoimmune Bullous Skin Disorder Intensity-Score (ABSIS) scores have been proposed to provide an objective measure of pemphigus activity. These scores have been evaluated only on already treated patients mainly with mild to moderate activity. The objective was to assess the interrater reliability of ABSIS and PDAI scores and their correlation with other severity markers in a large international study. Read More
Qual Health Res 2018 Oct 8:1049732318803590. Epub 2018 Oct 8.
2 Université de Rennes 2, Rennes, France.
This qualitative study conducted in France of "individuals living with a pemphigus" (ILPs; N = 54) highlights the taxing diagnostic trajectory of those suffering from these rare autoimmune diseases. Beyond enduring a diagnostic period that may prove long, during their numerous medical appointments, these individuals internalize the expectations of the medical professionals who are treating them. In some cases, numerous inconclusive medical tests and, at times, a doctor's condescension may push the patient toward a process of renunciation. Read More
Contemp Clin Dent 2018 Sep;9(Suppl 2):S373-S376
Department of Oral Pathology, Maulana Azad Institute of Dental Sciences, New Delhi, India.
Childhood pemphigus vulgaris (CPV) is a rare entity with clinical features and management primarily similar to those of adults; diagnosis may be difficult due to clinical similarity to other disorders such as herpetic gingivostomatitis which is more prevalent in this age group. We report two cases of CPV with emphasis on diagnostic approach. While treating such patients, it is imperative to diagnose CPV in the early stages to prevent serious morbidity and to adjust drug dosage to minimize side effects. Read More
Dermatol Ther 2018 Oct 5:e12767. Epub 2018 Oct 5.
Department of Dermatology, University of Naples Federico II, Naples, Italy.
Hailey-Hailey disease (HHD) also known as familial benign chronic pemphigus is a rare autosomal dominant genodermatosis. HHD treatment is often not satisfactory and hence, various modalities of treatment have been tried. We describe the case of a 37-year-old woman with a 2 years history of macerated erythematous plaques along with erosions, fissures, and crusts located on axillae and submammary areas, successfully treated with only oral supplementation of vitamin D (800 I. Read More
Dermatol Ther 2018 Oct 4:e12763. Epub 2018 Oct 4.
Department of Specialized, Clinical and Experimental Medicine, Division of Dermatology, University of Bologna, Bologna, Italy.
Clin Exp Dermatol 2018 Oct 4. Epub 2018 Oct 4.
Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago, Japan.