697 results match your criteria Pemphigoid Gestationis

Pemphigoid gestationis: a rare pregnancy dermatosis treated with a combination of IVIg and rituximab.

BMJ Case Rep 2021 Mar 16;14(3). Epub 2021 Mar 16.

Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India

Pemphigoid gestationis is a rare autoimmune subepidermal bullous dermatosis occurring during pregnancy and post partum. A 32-year-old woman developed itchy urticarial wheals over the trunk and extremities at 6 months of gestation. This was not controlled with antihistamines, and 2 months later, the patient developed multiple vesiculobullous lesions. Read More

View Article and Full-Text PDF

Subepidermal Autoimmune Blistering Dermatoses: Clinical Features and Diagnosis.

J Am Acad Dermatol 2021 Mar 5. Epub 2021 Mar 5.

Department of Dermatology, Mayo, Clinic Rochester, Minnesota; Department of Laboratory Medicine and Pathology, Mayo, Clinic, Rochester, Minnesota.

Subepidermal autoimmune blistering dermatoses are a group of rare skin disorders that are characterized by the disruption of the dermal-epidermal junction through the action of autoantibodies. The third article in this continuing medical education series explores the background, epidemiology, clinical features, and diagnostic criteria of each of the major subepidermal autoimmune blistering dermatoses, including bullous pemphigoid, pemphigoid gestationis, lichen planus pemphigoides, mucous membrane pemphigoid, linear IgA bullous dermatosis, and dermatitis herpetiformis. Read More

View Article and Full-Text PDF

Pruritic Skin Eruption in a Pregnant Woman.

Mayo Clin Proc 2021 02;96(2):427-428

Department of Dermatology, Mayo Clinic, Rochester, MN. Electronic address:

View Article and Full-Text PDF
February 2021

Pemphigoid Gestationis-A Rare Pregnancy Dermatoses.

J Obstet Gynaecol India 2020 Dec 12;70(6):527-528. Epub 2020 Jan 12.

Department of Pathology, Dr. Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, Baba Kharak Singh Marg, New Delhi, 110001 India.

Pemphigoid gestationis is a rare subepidermal bullous dermatosis of pregnancy, caused by the interaction of IgG1 auto-antibodies with 180 kD BP Antigen 2. This disease can lead to preterm delivery, but the neonate is affected in only 10% cases. The treatment of choice in pemphigoid gestationis is systemic corticosteroids. Read More

View Article and Full-Text PDF
December 2020

A Rare Case of Recurrent Postpartum Pemphigoid Gestationis with Fetal Complications and Skip Pregnancy.

Indian Dermatol Online J 2020 Nov-Dec;11(6):995-996. Epub 2020 Nov 8.

Department of Dermatology, Venereology, Leprology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.

View Article and Full-Text PDF
November 2020

A Systematic Review of Treatment Options and Clinical Outcomes in Pemphigoid Gestationis.

Front Med (Lausanne) 2020 20;7:604945. Epub 2020 Nov 20.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Treatment regimens for pemphigoid gestationis (PG) are non-standardized, with most evidence derived from individual case reports or small series. To systematically review current literature on treatments and clinical outcomes of PG and to establish recommendations on its therapeutic management. An a priori protocol was designed based on PRISMA guidelines. Read More

View Article and Full-Text PDF
November 2020

Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis.

Front Pharmacol 2020 2;11:583354. Epub 2020 Oct 2.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Pregnancy may induce the onset or exacerbation of autoimmune bullous diseases such as pemphigus or pemphigoid gestationis. A shift toward T helper (Th) 2 immune response and the influence of hormonal changes have been evoked as possible triggering factors. Therapeutic management of this setting of patients may represent a challenge, mainly due to safety concerns of some immunosuppressive drugs during pregnancy and lactation. Read More

View Article and Full-Text PDF
October 2020

Pemphigoid Gestationis.

N Engl J Med 2020 Aug;383(9):e61

University of Trieste, Trieste, Italy

View Article and Full-Text PDF

Rituximab in autoimmune pemphigoid diseases: Indications, optimized regimens, and practice gaps.

Clin Dermatol 2020 May - Jun;38(3):384-396. Epub 2019 Jul 26.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida, USA. Electronic address:

Rituximab is a monoclonal antibody targeting CD20 on B cells with proven efficacy for pemphigus vulgaris, now an FDA-approved indication. Other autoimmune bullous diseases can be challenging to treat and have significant associated morbidity and mortality, but data supporting the use of rituximab in pemphigoid group diseases remain limited. Although rituximab demonstrates efficacy for clinical improvement and remission in pemphigoid, concern for adverse events may also limit the use of this medication. Read More

View Article and Full-Text PDF
September 2020

Flame Figures in Linear Immunoglobulin A Bullous Dermatosis Secondary to Parvovirus B19 Infection.

Am J Dermatopathol 2021 Jan;43(1):60-62

Departments of Dermatology, and.

Abstract: Flame figures represent a characteristic but nondiagnostic histological finding in eosinophilic dermatoses. Some bullous autoimmune diseases with a predominant eosinophilic infiltrate, such as bullous pemphigoid, pemphigoid gestationis, and pemphigus vegetans, may show them. However, it is rare to find them in predominant neutrophilic bullous dermatoses such as linear immunoglobulin A. Read More

View Article and Full-Text PDF
January 2021

A Review Comparing International Guidelines for the Management of Bullous Pemphigoid, Pemphigoid Gestationis, Mucous Membrane Pemphigoid, and Epidermolysis Bullosa Acquisita.

Am J Clin Dermatol 2020 Aug;21(4):557-565

Department of Dermatology, University of Illinois at Chicago, 808 S. Wood St, RM377, Chicago, IL, 60612, USA.

Autoimmune blistering disease management can be challenging as treatment modalities vary greatly and no single standard of care exists. We consolidated the recommendations of international management guidelines in order to provide optimal management suggestions to physicians. A comprehensive literature search in PubMed/MEDLINE for published blistering disease management guidelines and consensus statements was conducted in November 2019. Read More

View Article and Full-Text PDF

Dyshidrosiform Bullous Pemphigoid: Case Reports and Review.

Philip R Cohen

Cureus 2020 Jan 11;12(1):e6630. Epub 2020 Jan 11.

Dermatology, San Diego Family Dermatology, San Diego, USA.

Bullous pemphigoid is an autoimmune blistering disorder that typically presents in elderly patients as pruritic tense subepidermal blisters on the lower trunk, axilla, and groin. It is caused by circulating and tissue-bound autoantibodies directed against bullous pemphigoid antigen 1 or bullous pemphigoid antigen 2 or both. Dyshidrosiform bullous pemphigoid is a rare variant of bullous pemphigoid, and it usually presents as itchy, potentially hemorrhagic, or purpuric blisters on the palms and/or soles of elderly individuals; subsequently, typical bullous lesions of bullous pemphigoid appear on other body sites. Read More

View Article and Full-Text PDF
January 2020

Pregnant Woman With Rash.

Ann Emerg Med 2020 02;75(2):306-314

Department of Osteopathic Medical Specialties, Michigan State University College of Osteopathic Medicine, East Lansing, MI; Sparrow Health System, Lansing, MI.

View Article and Full-Text PDF
February 2020

[Pemphigoid gestationis after egg donation : A case report].

E Oms M Tronnier

Hautarzt 2020 Mar;71(3):223-226

Dermatologie, Venerologie und Allergologie, Helios Klinikum Hildesheim, Senator-Braun-Allee 33, 31135, Hildesheim, Deutschland.

Pemphigoid gestationis (PG) is a blistering autoimmune skin disease, typically occurring in the second and third trimester of pregnancy. Aberrant expression of major histocompatibility complex (MHC) class II molecules on the chorionic villi seems to lead to antibody production against bullous pemphigoid (BP)-180. We report a case of PG in a woman whose pregnancy was achieved using egg donation. Read More

View Article and Full-Text PDF

Postpartum pruritic urticarial papules and plaques of pregnancy with blister formation resembling herpes gestationis.

Eur J Dermatol 2019 12;29(6):669-671

Department of Dermatology, Nara Medical University School of Medicine, 840 Shijo, Kashihara, Nara 634-8522.

View Article and Full-Text PDF
December 2019

Targetoid form of polymorphic eruption of pregnancy: A case report.

SAGE Open Med Case Rep 2019 14;7:2050313X19882841. Epub 2019 Oct 14.

Division of Dermatology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.

Polymorphic eruption of pregnancy, formerly known as pruritic and urticarial papules and plaques of pregnancy, is an uncommon cutaneous eruption that can affect women during their third trimester of pregnancy. As its name implies, it has a variety of morphologies and it is important to consider other diagnoses, such as pemphigoid gestationis, which polymorphic eruption of pregnancy can mimic. Sometimes, as in this case, polymorphic eruption of pregnancy can have a targetoid morphology reminiscent of erythema multiforme. Read More

View Article and Full-Text PDF
October 2019

What is causing this pregnant patient's rash?

JAAPA 2019 10;32(10):54-56

In the PA program at MGH Institute of Health Professions in Boston, Mass., Joshua Merson is an assistant professor and Dominique Caruso Murphy is an instructor. The authors have disclosed no potential conflicts of interest, financial or otherwise.

View Article and Full-Text PDF
October 2019

Pemphigoid gestationis.

Med Clin (Barc) 2020 04 7;154(8):327. Epub 2019 Sep 7.

Departamento de Dermatología, Hospital Universitario de Valme, Ctra. de Cádiz, Km. 548,9, 41001 Sevilla, Spain.

View Article and Full-Text PDF

Lichen Planus Pemphigoides: From Lichenoid Inflammation to Autoantibody-Mediated Blistering.

Front Immunol 2019 2;10:1389. Epub 2019 Jul 2.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

Lichen planus pemphigoides (LPP) is a very rare autoimmune sub-epidermal blistering disease associated with lichenoid skin changes. Initially thought to be a mere variant of more common inflammatory dermatoses, particularly Bullous Pemphigoid (BP) or Lichen Planus (LP), a growing body of evidence suggests that it is a disease entity in its own right. In common with a range of autoimmune blistering diseases, including BP, pemphigoid gestationis (PG), mucous membrane pemphigoid (MMP) and linear IgA dermatosis (LAD), a key feature of the disease is the development of autoantibodies against type XVII collagen (COL17). Read More

View Article and Full-Text PDF

Pemphigoid variants affecting the skin.

Clin Exp Dermatol 2019 Oct 16;44(7):721-727. Epub 2019 May 16.

Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Pemphigoid diseases are autoimmune subepidermal blistering diseases affecting the skin and mucous membranes, which are caused by autoantibodies targeting structural hemidesmosomal proteins or hemidesmosome-associated proteins. Variants of pemphigoid can be differentiated based on targeted antigens and clinical aspects. In this review, we will discuss pemphigoid variants that predominantly affect the skin, and provide clinicians with clues to diagnosis. Read More

View Article and Full-Text PDF
October 2019

Review of autoimmune blistering diseases: the Pemphigoid diseases.

J Eur Acad Dermatol Venereol 2019 Sep 11;33(9):1685-1694. Epub 2019 Jul 11.

St George Hospital, Sydney, Australia.

Autoimmune Blistering Diseases of the Pemphigoid type is characterised by sub-epidermal blisters (SEB) with circulating autoantibodies against components of the basement membrane zone (BMZ). The main disorders to date include bullous pemphigoid (BP), pemphigoid gestationis, mucous membrane pemphigoid (MMP), epidermolysis bullosa acquisita (EBA), linear IgA disease (LABD), dermatitis herpetiformis (DH), lichen planus pemphigoides and bullous lupus. This is in contrast to pemphigus and related disorders, which demonstrate intraepidermal acantholysis and a positive Nikolsky sign. Read More

View Article and Full-Text PDF
September 2019

Successful treatment of one case of pemphigoid gestationis complicating with polycystic ovary syndrome.

Dermatol Ther 2019 05 25;32(3):e12898. Epub 2019 Apr 25.

Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Pemphigoid gestationis (PG) is a rare, autoimmune, subepidermal bullous dermatosis associated with pregnancy. It is mainly caused by autoantibodies against hemidesmosomal proteins-bullous pemphigoid 180, and usually presents in the second or third trimester of pregnancy sometimes exacerbates spontaneously after delivery. Here we reported a case of PG with polycystic ovary syndrome (PCOS). Read More

View Article and Full-Text PDF

Treatment Update of Autoimmune Blistering Diseases.

Dermatol Clin 2019 Apr 14;37(2):215-228. Epub 2019 Feb 14.

Department of Medicine, University of Central Florida, Health Sciences Campus at Lake Nona, 2627 Northampton Avenue, Orlando, FL 32827-7408, USA. Electronic address:

The treatment of refractory autoimmune blistering diseases (AIBDs) has always been a challenge. Because randomized controlled trials are lacking, treatment has been based on analysis of anecdotal data. The last 2 decades has seen the use of rituximab become a conventional treatment in the therapeutic armamentarium of AIBDs, leading to its Food and Drug Administration indication for pemphigus vulgaris in 2018. Read More

View Article and Full-Text PDF

Pemphigoid Gestationis.

Clin Pract Cases Emerg Med 2019 Feb 7;3(1):79-80. Epub 2019 Jan 7.

Maricopa Medical Center, Department of Emergency Medicine, Phoenix, Arizona.

View Article and Full-Text PDF
February 2019

Pemphigoid Gestationis Mimicking Erythema Multiforme With Mucosal Involvement.

Actas Dermosifiliogr 2019 Oct 4;110(8):696-697. Epub 2019 Feb 4.

Departamento de Dermatología, Hospital del Mar-Parc Salut Mar, Barcelona, España.

View Article and Full-Text PDF
October 2019

Specific dermatoses of pregnancy other than pemphigoid gestationis.

G Ital Dermatol Venereol 2019 Jun 29;154(3):286-298. Epub 2018 Oct 29.

Section of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

Specific dermatoses of pregnancy are skin disorders that occur specifically during or immediately after pregnancy and cannot be found in non-pregnant patients. According to the current consensus, they include atopic eruption of pregnancy (AEP), polymorphic eruption of pregnancy (PEP), pemphigoid gestationis (PG), and intrahepatic cholestasis of pregnancy (ICP). The diagnosis of specific dermatoses of pregnancy can be challenging due to their variation in clinical presentation; moreover, the tests currently available do not always provide the clue for the diagnosis. Read More

View Article and Full-Text PDF

Autoimmune bullous diseases during pregnancy: insight into pathogenetic mechanisms and clinical features.

G Ital Dermatol Venereol 2019 Jun 29;154(3):256-262. Epub 2018 Oct 29.

Unit of Dermatology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy -

Pemphigoid gestationis (PG), also known as herpes gestationis, is the prototypic pregnancy-associated autoimmune bullous disease (AIBD), but also the other AIBDs, notably pemphigus vulgaris, may begin or exacerbate during pregnancy. Although the increase in concentration of T and B regulatory cells makes pregnancy a state of increased immunologic tolerance toward the semiallogeneic fetal antigens, a prevalent T helper (Th) 2 profile, that is reported to be associated with pregnancy, may cause exacerbation of pemphigus and AIBDs in general during this period. Active disease may lead to stillbirth, spontaneous abortion, preterm pregnancy, low birthweight, and neonatal pemphigus. Read More

View Article and Full-Text PDF

Pemphigoid gestationis and intravenous immunoglobulin therapy.

Int J Womens Dermatol 2018 Sep 3;4(3):166-169. Epub 2018 May 3.

Department of Dermatology, St. George Hospital, Sydney, Australia.

Pemphigoid gestationis, which is also known as herpes gestationis, is a rare, pregnancy-associated, autoimmune bullous disease. Treatment depends on the severity of the disease for each patient and the safety and use of these drugs during pregnancy and breastfeeding must be taken into consideration to guide their use. We describe the therapeutic response of two cases of pemphigoid gestationis that did not respond to conventional immunosuppressive therapy or adverse effects limited their use. Read More

View Article and Full-Text PDF
September 2018

Pemphigoid gestationis.

Clin Case Rep 2018 Jul 7;6(7):1364-1365. Epub 2018 May 7.

1st Department of Obstetrics and Gynecology "Alexandra" General Hospital University of Athens Lourou str., P.O. 11528 Athens Greece.

Pemphigoid gestationis is a rare autoimmune skin disorder emerging exclusively during pregnancy. Topical and oral glucocorticoids as well as oral antihistamines are the standard medications administered during pregnancy, aiming to relieve pruritus and to suppress extensive blister formation. Obstetricians should be able to recognize and treat this rare clinical condition accordingly. Read More

View Article and Full-Text PDF

Pruritus in Pregnancy and Its Management.

Mark A Bechtel

Dermatol Clin 2018 Jul 26;36(3):259-265. Epub 2018 Apr 26.

Division of Dermatology, Ohio State University College of Medicine, 540 Officenter Place, #240, Gahanna, OH 43230, USA. Electronic address:

Pruritus in pregnancy can be a source of significant discomfort in the pregnant patient. Some cases are associated with pregnancy-specific dermatoses, although some patients experience a flare of a preexisting dermatosis. Severe pruritus may be a manifestation of a pregnancy-specific dermatosis associated with increased fetal risks and complications. Read More

View Article and Full-Text PDF