718 results match your criteria Pemphigoid Gestationis


The association of six autoimmune bullous diseases with thyroid disorders: A population-based study.

J Eur Acad Dermatol Venereol 2022 May 25. Epub 2022 May 25.

Lűbeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Background: The association of autoimmune bullous diseases (AIBDs) with thyroid disorders remains to be profoundly investigated.

Objective: To evaluate the epidemiological association between six AIBDs and thyroid disorders.

Methods: A population-based cross-sectional study enrolled patients with bullous pemphigoid (BP), mucous membrane pemphigoid (MMP), epidermolysis bullosa acquisita (EBA), pemphigoid gestationis (PG), pemphigus vulgaris (PV), and pemphigus foliaceus (PF). Read More

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Successful treatment of recalcitrant pemphigoid gestationis with omalizumab: report of two cases.

J Eur Acad Dermatol Venereol 2022 May 19. Epub 2022 May 19.

Immunology Department, University Hospital of Toulouse, Paul Sabatier University, Toulouse, France.

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Pemphigoid Gestationis and adverse pregnancy outcomes: A literature review.

J Gynecol Obstet Hum Reprod 2022 May 3;51(5):102370. Epub 2022 Apr 3.

Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Malaysia.

Pemphigoid gestationis (PG), also known as gestational pemphigoid, as it is specifically associated with a pregnancy event, is among the rare pregnancy-related dermatoses, characterised by the formation of autoantibodies against Bullous Pemphigoid antigens 180 and 230 (BP180 and BP230), causing significant damage to the basement membrane of the skin, resulting in marked pruritus and blisters on the abdomen and extremities. Diagnosis of PG is basically made by the characteristic clinical picture and confirmed by immunofluorescence studies and histopathology of a skin biopsy. Treatment, just as for other autoimmune dermatoses, is achieved by corticosteroids with the risk of relapses in subsequent pregnancies. Read More

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[Skin and pregnancy].

Rev Med Suisse 2022 Mar;18(775):596-603

Service de dermatologie et vénéréologie, Département de médecine, Hôpitaux universitaires de Genève, 1211 Genève 14.

Pregnancy has a substantial impact on the hormonal status of the organism, consequently influencing the physiology of the skin. This results in dermatoses that only occur during pregnancy, which can also improve or exacerbate pre-existing dermatoses. In this article, we explain the management of pregnancy-specific dermatoses : atopic eruption of pregnancy, polymorphic eruption of pregnancy, pemphigoid gestationis, impetigo herpetiformis, and intrahepatic cholestasis of pregnancy. Read More

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Pruritus in Pregnancy.

Am J Clin Dermatol 2022 Mar 21;23(2):231-246. Epub 2022 Feb 21.

Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Von Esmarch Str 58, 48149, Münster, Germany.

Pruritus in pregnancy is a common and burdensome symptom that may be a first sign of a pregnancy-specific pruritic disease (atopic eruption of pregnancy, polymorphic eruption of pregnancy, pemphigoid gestationis, and intrahepatic cholestasis in pregnancy) or a dermatosis coinciding with pregnancy by chance. Despite its high prevalence, pruritus is often underrated by physicians, and data regarding the safety profiles of drugs for pruritus are very limited. In this review, we illustrate the epidemiology, possible pathophysiology, clinical characteristics, and diagnostic workup of various pregnancy-related diseases and discuss antipruritic treatments. Read More

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Diagnosis, fetal risk and treatment of pemphigoid gestationis in pregnancy: A case report.

World J Clin Cases 2021 Dec;9(34):10645-10651

Department of Obstetrics and Gynecology, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Background: Pemphigoid gestationis (PG) is a rare autoimmune blistering disease that usually presents in the second or third trimester, with an incidence of 1 per 50000 pregnancies. PG tends to recur with an earlier onset and a more severe course in subsequent pregnancies. Skin biopsy markers can be confirmed by direct immunofluorescence staining. Read More

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December 2021

Autoreactivity to BP180 Neoepitopes in Patients With Pemphigoid Gestationis.

JAMA Dermatol 2022 02;158(2):212-214

Department of Dermatology, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.

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February 2022

Annular bullous diseases.

Clin Dermatol 2022 Jan 1. Epub 2022 Jan 1.

Department of Dermatology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.

Annular bullous dermatoses represent an etiologically diverse group of cutaneous phenomena that present with a figurate morphology in association with vesicles and bullae. This group of diverse conditions consists of bullous pemphigoid; pemphigoid gestationis; epidermolysis bullosa simplex, Dowling-Meara type; linear immunoglobulin A bullous dermatosis; chronic bullous disease of childhood; anti-p200 pemphigoid; subcorneal pustular dermatosis; and immunoglobulin A pemphigus. Astute examination of clinical, histopathologic, and serologic features is crucial in distinguishing these bullous dermatoses. Read More

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January 2022

Newborn twins with neonatal pemphigoid gestationis.

J Dermatol 2022 05 23;49(5):e157-e158. Epub 2021 Dec 23.

Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.

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Assessment and management of itchy skin in pregnancy.

Aust J Gen Pract 2021 12;50(12):898-903

AM, BSc (Hons), MBBS, MPH, FACD, FAFOEM, Consultant Dermatologist and Occupational Physician; Adjunct Clinical Associate Professor, Monash University, Vic; Honorary Associate Professor, The University of Melbourne, Vic; Director, Occupational Dermatology Research and Education Centre, Vic.

Background: Women with rashes or itchy skin during pregnancy will often present initially to the general practitioner. Knowledge of the specific dermatoses of pregnancy will assist in diagnosis, management and, importantly, facilitation of timely escalation of care of conditions that can potentially affect the fetus.

Objective: The aim of this article is to provide a diagnostic framework for approaching a pruritic rash during pregnancy as well as a helpful summary of management of pregnancy-specific dermatoses. Read More

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December 2021

Influence of pemphigoid gestationis on pregnancy outcome: A case report and review of the literature.

Exp Ther Med 2022 Jan 4;23(1):23. Epub 2021 Nov 4.

Department of Obstetrics and Gynecology, Life Memorial Hospital, 012244 Bucharest, Romania.

Pemphigoid gestationis is considered to be a rare pregnancy exclusive bullous disease, which modifies the course of the pregnancy, with difficulties in the management of the pruritus and skin lesions as well as a possible change in the neonatal outcome. Differential diagnosis of skin lesions and pruritus in pregnancy is challenging, and complementary investigations such as skin biopsy or laboratory tests are indispensable. The correct diagnosis and proper treatment could change the natural course of a pregnancy at risk and could improve maternal and fetal morbidity. Read More

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January 2022

Neonatal pemphigoid gestationis: An atypical presentation of a rare disease.

Pediatr Dermatol 2021 Nov 29;38(6):1575-1576. Epub 2021 Oct 29.

Department of Dermatology, University of Utah, Salt Lake City, Utah, USA.

Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by urticarial plaques and/or vesicles and tense bullae. A unique presentation of BP can occur during pregnancy, the postpartum period after delivery, or with the initiation of contraception, in which case it is referred to as pemphigoid gestationis (PG). In rare instances, newborns born to mothers with PG may also present with blisters due to transplacental passage of maternal anti-bullous pemphigoid 180 (BP180) or 230 (BP230) immunoglobulin G (IgG). Read More

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November 2021

A multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey.

Australas J Dermatol 2021 Nov 12;62(4):e496-e503. Epub 2021 Oct 12.

Faculty of Medicine, Department of Dermatology, Karadeniz Technical University, Trabzon, Turkey.

Background: The differentiation between the pemphigoid diseases is essential for treatment and prognosis. In Turkey, data on the incidence of these diseases are insufficient. Our aim in this study is to determine the incidence, demographics and clinical characteristics associated with diseases of the pemphigoid group. Read More

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November 2021

The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016.

PLoS One 2021 13;16(7):e0254634. Epub 2021 Jul 13.

Faculty of Dentistry, University of Khartoum, Khartoum, Khartoum State, Sudan.

Objectives: Autoimmune bullous diseases vary in their clinico-epidemiological features and burden across populations. Data about these diseases was lacking in Sudan. We aimed to describe the epidemiological profile and to estimate the burden of autoimmune bullous diseases in Sudan. Read More

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November 2021

Pemphigoid Gestationis - Case Report and Review of Literature.

Clin Cosmet Investig Dermatol 2021 16;14:665-670. Epub 2021 Jun 16.

Department of Dermatology, Pediatric Dermatology and Oncology Clinic, Medical University of Lodz, Lodz, Poland.

Pemphigoid gestationis (PG) is a rare autoimmune bullous skin disorder which usually presents with intense pruritus and urticarial lesions that may evolve into vesicles and tense blisters. In majority of patients, it starts in the second or third trimester of pregnancy and resolves spontaneously after delivery. Lesions appear in the periumbilical area in 90% of patients and rapidly spread centrifugally to other parts of the body. Read More

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The burden of neurological comorbidities in six autoimmune bullous diseases: a population-based study.

J Eur Acad Dermatol Venereol 2021 Oct 4;35(10):2074-2078. Epub 2021 Aug 4.

Lűbeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Background: Apart from bullous pemphigoid (BP), the association of other autoimmune bullous diseases (AIBDs) with neurological conditions is poorly understood.

Objective: To estimate the association between a wide array of AIBDs and neurological conditions.

Methods: A retrospective cross-sectional study recruited patients with BP, mucous membrane pemphigoid (MMP), epidermolysis bullosa acquisita (EBA), pemphigoid gestationis (PG), pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Read More

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October 2021

Treatment of pemphigoid gestationis with dupilumab.

Clin Exp Dermatol 2021 Dec 22;46(8):1578-1579. Epub 2021 Jul 22.

Dermatology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.

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December 2021

Neonatal Rash.

J Pediatr 2021 Aug 19;235:296-297. Epub 2021 Apr 19.

Department of Neonatology, Centro Hospitalar Póvoa de Varzim/Vila do Conde, Porto, Portugal.

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Pemphigoid gestationis: a rare pregnancy dermatosis treated with a combination of IVIg and rituximab.

BMJ Case Rep 2021 Mar 16;14(3). Epub 2021 Mar 16.

Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India

Pemphigoid gestationis is a rare autoimmune subepidermal bullous dermatosis occurring during pregnancy and post partum. A 32-year-old woman developed itchy urticarial wheals over the trunk and extremities at 6 months of gestation. This was not controlled with antihistamines, and 2 months later, the patient developed multiple vesiculobullous lesions. Read More

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Subepithelial autoimmune blistering dermatoses: Clinical features and diagnosis.

J Am Acad Dermatol 2021 Jul 5;85(1):1-14. Epub 2021 Mar 5.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

Subepithelial autoimmune blistering dermatoses are a group of rare skin disorders that are characterized by the disruption of the dermal-epidermal junction through the action of autoantibodies. The third article in this continuing medical education series explores the background, epidemiology, clinical features, and diagnostic criteria of each of the major subepithelial autoimmune blistering dermatoses, including bullous pemphigoid, pemphigoid gestationis, lichen planus pemphigoides, mucous membrane pemphigoid, linear IgA bullous dermatosis, and dermatitis herpetiformis. Read More

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Pruritic Skin Eruption in a Pregnant Woman.

Mayo Clin Proc 2021 02;96(2):427-428

Department of Dermatology, Mayo Clinic, Rochester, MN. Electronic address:

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February 2021

Pemphigoid Gestationis-A Rare Pregnancy Dermatoses.

J Obstet Gynaecol India 2020 Dec 12;70(6):527-528. Epub 2020 Jan 12.

Department of Pathology, Dr. Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, Baba Kharak Singh Marg, New Delhi, 110001 India.

Pemphigoid gestationis is a rare subepidermal bullous dermatosis of pregnancy, caused by the interaction of IgG1 auto-antibodies with 180 kD BP Antigen 2. This disease can lead to preterm delivery, but the neonate is affected in only 10% cases. The treatment of choice in pemphigoid gestationis is systemic corticosteroids. Read More

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December 2020

A Rare Case of Recurrent Postpartum Pemphigoid Gestationis with Fetal Complications and Skip Pregnancy.

Indian Dermatol Online J 2020 Nov-Dec;11(6):995-996. Epub 2020 Nov 8.

Department of Dermatology, Venereology, Leprology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.

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November 2020

A Systematic Review of Treatment Options and Clinical Outcomes in Pemphigoid Gestationis.

Front Med (Lausanne) 2020 20;7:604945. Epub 2020 Nov 20.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Treatment regimens for pemphigoid gestationis (PG) are non-standardized, with most evidence derived from individual case reports or small series. To systematically review current literature on treatments and clinical outcomes of PG and to establish recommendations on its therapeutic management. An a priori protocol was designed based on PRISMA guidelines. Read More

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November 2020

Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis.

Front Pharmacol 2020 2;11:583354. Epub 2020 Oct 2.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Pregnancy may induce the onset or exacerbation of autoimmune bullous diseases such as pemphigus or pemphigoid gestationis. A shift toward T helper (Th) 2 immune response and the influence of hormonal changes have been evoked as possible triggering factors. Therapeutic management of this setting of patients may represent a challenge, mainly due to safety concerns of some immunosuppressive drugs during pregnancy and lactation. Read More

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October 2020

Intravenous Immunoglobulin Therapy for Gestational Pemphigoid Refractory to Conventional Treatment.

Actas Dermosifiliogr (Engl Ed) 2021 Jan 25;112(1):83-85. Epub 2020 Sep 25.

Unidad de Medicina Materno-Fetal, Servicio de Obstetricia, Hospital Universitario La Paz, Madrid, España.

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January 2021

Pemphigoid Gestationis.

N Engl J Med 2020 Aug;383(9):e61

University of Trieste, Trieste, Italy

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Rituximab in autoimmune pemphigoid diseases: Indications, optimized regimens, and practice gaps.

Clin Dermatol 2020 May - Jun;38(3):384-396. Epub 2019 Jul 26.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida, USA. Electronic address:

Rituximab is a monoclonal antibody targeting CD20 on B cells with proven efficacy for pemphigus vulgaris, now an FDA-approved indication. Other autoimmune bullous diseases can be challenging to treat and have significant associated morbidity and mortality, but data supporting the use of rituximab in pemphigoid group diseases remain limited. Although rituximab demonstrates efficacy for clinical improvement and remission in pemphigoid, concern for adverse events may also limit the use of this medication. Read More

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September 2020