7,135 results match your criteria Pemphigoid Gestationis
J Invest Dermatol 2018 Dec 10. Epub 2018 Dec 10.
Department of Dermatology, Rouen University Hospital and INSERM U1234, Centre de référence des maladies bulleuses autoimmunes, Normandie University, Rouen.
Dipeptidyl-peptidase-IV-inhibitors have been suspected to induce bullous pemphigoid (BP). The objective of this study was to compare the observed frequency of gliptin intake in a large sample of 1787 BP patients diagnosed between 2012 and 2015 in France, with the expected frequency after indirect age standardization on 225412 individuals extracted from the database of the National Healthcare Insurance Agency. The secondary objective was to assess the clinical characteristics and the course of gliptin-associated BP depending on whether gliptin was continued or stopped. Read More
Front Immunol 2018 20;9:2687. Epub 2018 Nov 20.
Department of Dermatology, Medical Faculty, Medical Center - University of Freiburg, Freiburg, Germany.
Bullous pemphigoid is a subepidermal blistering skin disease, associated with autoantibodies to hemidesmosomal proteins, complement activation at the dermal-epidermal junction, and dermal granulocyte infiltration. Clinical and experimental laboratory findings support conflicting hypotheses regarding the role of complement activation for the skin blistering induced by pemphigoid autoantibodies. In-depth studies on the pathogenic relevance of autoimmune complement activation in patients are largely lacking. Read More
Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.
Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Exosomes are a type of endosome that can mediate communication between cells and the transport of cellular components such as microRNAs, mRNAs, proteins and DNA. Recently, exosomes have been under investigation for their significant roles in both healthy physiology and disease states. Herein, we review the role of exosomes in chronic inflammatory skin diseases and skin tumors, especially focusing on systemic lupus erythematosus, psoriasis, atopic dermatitis, bullous pemphigoid and melanoma. Read More
J Dermatol 2018 Dec 7. Epub 2018 Dec 7.
Department of Dermatology, Graduate School of Medicine, Mie University, Tsu, Japan.
Eur J Dermatol 2018 Dec 10. Epub 2018 Dec 10.
Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago, Japan.
J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.
Loyola Univ Medical Center Dermatology, 321 N La Grange Rd, La, Grange Park, IL. Electronic address:
The incidence of zoster is increased in many autoimmune diseases. This study found a significantly increased zoster incidence in dermatomyositis and cutaneous lupus erythematosus compared with a control group.Physicians should be aware of this risk and consider administering the vaccine against zoster to these patients if not contraindicated. Read More
Hautarzt 2018 Dec 5. Epub 2018 Dec 5.
Klinik für Dermatologie, Allergologie und Venerologie, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.
Autoimmmune bullous diseases are mediated by pathogenetically relevant autoantibodies against components of the epidermis and/or superficial mucous membranes (in pemphigus) and structural proteins of the dermal-epidermal junction (in pemphigoid diseases). Using immunoadsorption (IA), an already well-established procedure in cardiac and rheumatic disorders, antibodies can be removed from the plasma. At present, most data on the adjuvant use of IA in dermatology are derived from patients with severe and/or refractory pemphigus vulgaris or pemphigus foliaceus and also from patients with pemphigoid diseases. Read More
Int J Dermatol 2018 Dec 5. Epub 2018 Dec 5.
Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Arch Dermatol Res 2018 Dec 4. Epub 2018 Dec 4.
Department of Dermatology, Faculty of Medicine Cairo University, Kasr Al Ainy Hospital, Al Manial, Cairo, 11956, Egypt.
Bullous pemphigoid (BP) is a chronic autoimmune skin disease. Aquaporin 3 (AQP 3) has a possible role in the pathogenesis of many dermatological diseases. In this work, we aimed to evaluate the expression of AQP 3 in BP. Read More
Rev Prat 2017 12;67(10):1080-1083
Département de dermatologie, centre hospitalier universitaire de Rouen ; Inserm U1234, Institut de recherche et d'innovation biomédicale, université de Rouen, Rouen, France.
Bullous pemphigoid, a dermatosis of the elderly. Bullous pemphigoid is the most common autoimmune bullous disease and affects almost exclusively the elderly. Its occurrence is related to the presence of pathogenic autoantibodies directed against structural proteins (BP180 and BP230) of the protein adhesion complex of the dermo-epidermal junction: the hemi-desmosome. Read More
JAMA Dermatol 2018 Nov 28. Epub 2018 Nov 28.
Department of Dermatology, Reims University Hospital, University of Reims Champagne-Ardenne, Reims, France.
Importance: Development of transient palmoplantar keratoderma (PPK) with bullous pemphigoid (BP) has only been described in 2 isolated case reports. The clinical significance and the pathophysiologic mechanisms of this association are unknown.
Objective: To examine the clinical characteristics and immunological profile of patients with BP who develop transient PPK and analyze therapeutic options and outcomes. Read More
Front Med (Lausanne) 2018 8;5:306. Epub 2018 Nov 8.
Department of Dermatology, University of Pennsylvania, Philadelphia, PA, United States.
The 5th Scientific Conference of the International Pemphigus and Pemphigoid Foundation (IPPF), "Pemphigus and Pemphigoid: A New Era of Clinical and Translational Science" was held in Orlando, Florida, on May 15-16, 2018. Scientific sessions covered recent, ongoing, and future clinical trials in pemphigus and bullous pemphigoid, disease activity and quality of life instruments, and the IPPF Natural History Study. Furthermore, the meeting provided an opportunity to hear firsthand from patients, investigators, and industry about their experience enrolling for clinical trials. Read More
Hautarzt 2018 Nov 20. Epub 2018 Nov 20.
Klinik- und Poliklinik für Haut- und Geschlechtskrankheiten, Universitätsmedizin Greifswald, Greifswald, Deutschland.
The rare case of a 61-year-old patient suffering from linear IgA dermatosis is presented. The patient was previously hospitalized with chronic inflammatory bowel disease. The correct diagnosis of the disease was based on clinical and histological findings. Read More
Pharmacol Res Perspect 2018 Dec 8;6(6):e00438. Epub 2018 Nov 8.
Department of Dermatology, Allergy, and Venereology University of Lübeck Lübeck Germany.
ω3-polyunsaturated free fatty acids (ω3-PUFAs), particularly docosahexaenoic (DHA) and eicosapentaenoic acid (EPA), are thought to exert health promoting effects in metabolic and in inflammatory diseases. The molecular mechanisms of these beneficial effects are only partially understood. DHA and EPA activate (GPR120/FFA4). Read More
Front Med (Lausanne) 2018 2;5:296. Epub 2018 Nov 2.
Department of Dermatology, University of Lübeck, Lübeck, Germany.
Autoimmune skin blistering diseases (AIBD) are characterized by autoantibodies that are directed against structural proteins in the skin and adjacent mucous membranes. Some clinical signs are typical for a specific AIBD, however, correct diagnosis requires the detection of tissue-bound or circulating autoantibodies. The gold standard for diagnosis of AIBD is the detection of autoantibodies or complement component 3 by direct immunofluorescence (DIF) microscopy of a perilesional biopsy. Read More
Am J Pathol 2018 Nov 15. Epub 2018 Nov 15.
Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States. Electronic address:
High levels of proinflammatory cytokines have been associated with loss of tissue function in ocular autoimmune diseases but the basis for this relationship remains poorly understood. Here we investigated a new role for tumor necrosis factor (TNF)-α in promoting N-glycan processing deficiency at the surface of the eye through inhibition of N-acetylglucosaminyltransferase expression in the Golgi. Using mass spectrometry, complex-type biantennary oligosaccharides were identified as major N-glycan structures in differentiated human corneal epithelial cells. Read More
Acta Clin Croat 2018 Jun;57(2):342-351
Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Although cheilitis as a term describing lip inflammation has been identified and recognized for a long time, until now there have been no clear recommendations for its work-up and classification. The disease may appear as an isolated condition or as part of certain systemic diseases/conditions (such as anemia due to vitamin B12 or iron deficiency) or local infections (e.g. Read More
J Pathol 2018 Nov 14. Epub 2018 Nov 14.
Department of Dermatology, Hokkaido University Graduate School of Medicine.
Immunoglobulins consist of two antigen-binding regions (Fab) and one constant region (Fc). Protein A and protein G are bacterial proteins used for the purification of IgG by virtue of their high affinities for Fc fragment. Rheumatoid factors are autoantibodies against IgG Fc fragments, which are present in the body under physiological conditions. Read More
Am J Clin Dermatol 2018 Nov 13. Epub 2018 Nov 13.
Department of Dermatology, Beilinson Hospital, Rabin Medical Center, Petah-Tikva, 49100, Israel.
Background: Bullous pemphigoid (BP) is the most common autoimmune blistering skin disease worldwide. Systemic corticosteroids are considered the mainstay of therapy; however, they may cause significant adverse effects and treatment failures, so additional therapeutic modalities with better safety profiles are required. Rituximab and omalizumab are novel biologic agents administered in recent years for the treatment of BP, yet data regarding their use in the disease are limited. Read More
J Am Acad Dermatol 2018 Dec;79(6):e113-e114
PEDEGO Research Unit, University of Oulu, Department of Dermatology and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.
J Am Acad Dermatol 2018 Dec;79(6):e111-e112
Department of Dermatology, Rambam Health Care Campus, Haifa, Israel and the School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel. Electronic address:
Skin Appendage Disord 2018 Oct 20;4(4):308-311. Epub 2018 Apr 20.
Universidade Federal Fluminense, Niterói, Brazil.
Brunsting-Perry type pemphigoid (BPP) is a rare subepidermal blistering disease and a cause of secondary cicatricial alopecia. It was originally described by Brunsting and Perry in 1957 as a rare variant of cicatricial pemphigoid, characterized by bullous lesions limited to the head, neck, scalp, and upper trunk with mild or no mucosal involvement. We report 2 cases of BPP cicatricial alopecia with histopathology of subepidermal blister formation, different clinical presentation, and different salt-split test results. Read More
J Dtsch Dermatol Ges 2018 Nov;16(11):1339-1358
Department of Dermatology and Allergology, Marburg University Medical Center, Marburg, Germany.
Pathophysiologically, bullous autoimmune dermatoses are caused by autoantibodies directed against adhesion molecules or structural proteins of the skin and mucous membranes, clinically resulting in blister formation. Depending on the respective target proteins of the autoimmune response and their location in the skin, a distinction is made between intraepidermal (pemphigus disorders), junctional (pemphigoid disorders), and subepidermal (epidermolysis bullosa acquisita, dermatitis herpetiformis) autoimmune blistering diseases. The most common bullous autoimmune dermatosis, bullous pemphigoid is characterized by marked clinical variability and intense pruritus. Read More
J Eur Acad Dermatol Venereol 2018 Nov 5. Epub 2018 Nov 5.
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Background: Bullous pemphigoid (BP) is the most common autoimmune blistering disease. BP180 is the primary autoantigen of BP, and in a portion of BP cases, BP230 is the only target of autoantibodies. Such BP is called BP230-type BP. Read More
Acta Dermatovenerol Croat 2018 Oct;26(3):243-248
Rana Rafiei, MD , Skin Research Center , Guilan University of Medical Sciences , Razi Hospital , Rasht , Iran;
Bullous pemphigoid is an acquired autoimmune subepidermal blistering disease which is associated with mucocutaneous lesions. The type and amount of autoantibody deposition may have a role in mucosal lesions. We studied the association between mucosal involvement and direct immunofluorescence pattern in cutaneous lesions of patients with bullous pemphigoid. Read More
Head Neck Pathol 2018 Nov 2. Epub 2018 Nov 2.
Department of Anatomic Pathology, Naval Medical Center San Diego, San Diego, CA, USA.
Reticular oral lichen planus is a common clinical finding, often found incidentally on routine oral examination. Patients rarely complain of symptoms and the condition does not require treatment, as a result, biopsies and ancillary laboratory evaluation are seldom performed. We present a case of reticular oral lichen planus with a classic clinical presentation and characteristic histologic findings. Read More
Br J Dermatol 2018 Nov;179(5):1030
Department of Dermatology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, U.S.A.
Front Med (Lausanne) 2018 17;5:266. Epub 2018 Oct 17.
Department of Dermatology, Rambam Health Care Campus, Haifa, Israel.
The specificity and the predictive values of indirect immunofluorescence (IIF) in real-life settings is yet to be firmly established. The natural history of patients with false-positive results has not been sufficiently elucidated. The primary aim of the current study is to evaluate the diagnostic value of IIF analysis on monkey esophagus in pemphigus, utilizing a large cohort arising from the real-life experience of a tertiary referral center. Read More
Arch Dermatol Res 2018 Oct 31. Epub 2018 Oct 31.
Department of Dermatology, Emek Medical Center, Afula, Israel.
There are differences concerning reported mortality rates and prognostic factors of bullous pemphigoid (BP) patients in different studies. Our objectives were to evaluate the mortality rates and prognostic factors among Israeli BP patients compared to matched control subjects. Three age- and sex-matched patients without BP (n = 261) who were treated in our clinic were selected and compared to BP patients (n = 87). Read More
G Ital Dermatol Venereol 2018 Oct 29. Epub 2018 Oct 29.
Section of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
Specific dermatoses of pregnancy are skin disorders that occur specifically during or immediately after pregnancy and cannot be found in non-pregnant patients. According to the current consensus, they include atopic eruption of pregnancy (AEP), polymorphic eruption of pregnancy (PEP), pemphigoid gestationis (PG), and intrahepatic cholestasis of pregnancy (ICP). The diagnosis of specific dermatoses of pregnancy can be challenging due to their variation in clinical presentation; moreover, the tests currently available do not always provide the clue for the diagnosis. Read More
G Ital Dermatol Venereol 2018 Oct 29. Epub 2018 Oct 29.
Dermatology Unit, Department of Physiopathology and Transplantation, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy -
Pemphigoid gestationis (PG), also known as herpes gestationis, is the prototypic pregnancy-associated autoimmune bullous disease (AIBD), but also the other AIBDs, notably pemphigus vulgaris, may begin or exacerbate during pregnancy. Although the increase in concentration of T and B regulatory cells makes pregnancy a state of increased immunologic tolerance toward the semiallogeneic fetal antigens, a prevalent T helper (Th) 2 profile, that is reported to be associated with pregnancy, may cause exacerbation of pemphigus and AIBDs in general during this period. Active disease may lead to stillbirth, spontaneous abortion, preterm pregnancy, low birthweight, and neonatal pemphigus. Read More
Hum Mutat 2018 Oct 29. Epub 2018 Oct 29.
Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy.
Hereditary sensory and autonomic neuropathies (HSAN) are clinically and genetically heterogeneous disorders, characterized by a progressive sensory neuropathy often complicated by ulcers and amputations, with variable motor and autonomic involvement. Several pathways have been implicated in the pathogenesis of neuronal degeneration in HSAN, while recent observations point to an emerging role of cytoskeleton organization and function. Here, we report novel biallelic mutations in the DST gene encoding dystonin, a large cytolinker protein of the plakin family, in an adult form of HSAN type VI. Read More
G Ital Dermatol Venereol 2018 10 22. Epub 2018 Oct 22.
Laboratory of Dermatopathology, San Gallicano Dermatological Institute, IRCCS, Rome, Italy.
Int J Dermatol 2018 Oct 22. Epub 2018 Oct 22.
Department of Dermatology and Immunodermatology, Medical University of Warsaw, Warsaw, Poland.
Background: Bullous pemphigoid (BP) is an autoimmune blistering disease associated with preexisting comorbidities and higher mortality. The interest in using therapy other than oral steroids in BP management results from severe complications and increased risk of death. The efficacy of oral doxycycline or whole-body application of topical clobetasol has been proven in randomized controlled trials. Read More
J Ophthalmol 2018 19;2018:8372146. Epub 2018 Sep 19.
Oral Medicine Complex Unit, Department of Neuroscience, Reproductive and Odontostomatological Sciences, University "Federico II" of Naples, Naples, Italy.
Mucous membrane pemphigoid (MMP) is a heterogeneous group of rare, systemic, autoimmune subepidermal inflammatory disease that affects mucous membranes and the eye. In its most severe forms, this disease needs systemic therapy, usually based on steroids and immunosuppressant agents. In unresponsive cases or in the presence of contraindications or severe side effects due to conventional systemic corticosteroid and/or immunosuppressant therapy, a therapy shift to high-dose intravenous immunoglobulins (IVIg) has been recommended in other reports. Read More
Eur J Dermatol 2018 Aug;28(4):440-448
Di.S.Sal, Section of Dermatology, University of Genoa, San Martino Policlinic Hospital, Genoa 16132, Italy.
Clinical features and histological findings in bullous pemphigoid (BP) suggest a Th2-oriented inflammatory reaction, especially in the early stages of the disease. Elevated total serum IgE levels, blood eosinophilia, and elevated serum levels of different soluble inflammatory Th2 response mediators have been described in large cohorts of patients with classic clear-cut BP manifestations. Direct immunofluorescence, indirect immunofluorescence, and anti-BP230 and anti-BP180 IgE ELISA testing show self-reactive IgE autoantibodies in a consistent number of BP patients. Read More
Eur J Dermatol 2018 Oct;28(5):711-713
Laboratory of Immunology, Papageorgiou General Hospital, Thessaloniki, Greece.
Eur J Dermatol 2018 Oct;28(5):708-710
Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy.
J Alzheimers Dis 2018 ;66(2):743-750
Recent studies have shown an epidemiological and immunological association between bullous pemphigoid (BP) and several neurological or psychiatric diseases. Here, our aim was for the first time to specify whether an association exists between BP and frontotemporal lobar degeneration (FTLD). Medical histories of FTLD patients (N = 196) were screened for clinical comorbidity, and BP180 and BP230 autoantibodies were analyzed in the sera of FTLD patients (N = 70, including 24 C9orf72 repeat expansion carriers) by BP180-NC16A-ELISA and BP230-ELISA. Read More
Front Med (Lausanne) 2018 27;5:268. Epub 2018 Sep 27.
Department of Dermatology and Referral Center for Auto-Immune Bullous Diseases MALIBUL, Avicenne Hospital, AP-HP, University Paris 13, Bobigny, France.
An 83-year-old patient developed erosions and a blister of the gingival mucous membrane, 6 months after discontinuation of the anti-programmed death-1 (anti PD-1) pembrolizumab therapy administered for 10 months for a metastatic melanoma. A diagnosis of mild mucous membrane pemphigoid (MMP) was made. Complete remission of MMP was rapidly obtained with minimal therapy (doxycycline). Read More
Br J Dermatol 2018 Oct;179(4):820-821
Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Postgrad Med J 2018 Oct 13. Epub 2018 Oct 13.
Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
J Invest Dermatol 2018 Oct 10. Epub 2018 Oct 10.
Department of Dermatology, PEDEGO Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. Electronic address:
Neurological patients have an increased risk for bullous pemphigoid (BP) in which autoantibodies target BP180, a cutaneous basement membrane protein also expressed in the brain. Here we show that 53.6% sera of patients with multiple sclerosis (MS) (n=56) had IgG reactivity against full-length BP180 in immunoblotting, while in BP180-NC16A ELISA (n=143), only 7. Read More
Br J Dermatol 2018 Oct 13. Epub 2018 Oct 13.
Luebeck Institute of Experimental Dermatology (LIED), University of Luebeck, Luebeck, Germany.
Background: Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering skin disease. Two antigens were identified as targets of circulating autoantibodies (abs), BP180 and BP230, with BP180 being a critical transmembrane adhesion protein of basal keratinocytes of the epidermis. The non-collagenous domain 16A (NC16A) of BP180 is the immunodominant epitope in BP patients, and anti-BP180-NC16A immunoglobulin G (IgG) abs correlate to disease activity. Read More
Br J Dermatol 2018 Oct 11. Epub 2018 Oct 11.
Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan.
Background: Epidermolysis bullosa acquisita (EBA) is a rare pemphigoid disease involving autoantibodies to type VII collagen (COL7), a major structural component of anchoring fibrils. IgE autoantibodies to type XVII collagen (BP180) have been identified in bullous pemphigoid (BP), the prototype of pemphigoid diseases. Although the pathogenic relevance of IgG anti-COL7 has been investigated, that of IgE in EBA remains unclear. Read More
J Eur Acad Dermatol Venereol 2018 Oct;32(10):1623-1624
Department of Dermatology, Philipps University, Marburg, Germany.
JRSM Open 2018 Oct 3;9(10):2054270418793029. Epub 2018 Oct 3.
Department of Dermatology, Queen Elizabeth Hospital, London SE18 4QH, UK.
Immunotherapy is now being routinely used in the management of many cancers. It is therefore vital that all clinicians are aware of the diverse array of cutaneous manifestations that can result from their use, which can vary from mild to life threatening. Read More
G Ital Dermatol Venereol 2018 Oct 4. Epub 2018 Oct 4.
U.O.C. Dermatologia, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Background: Mucous membrane pemphigoid (MMP) is an autoimmune disease characterized by scarring lesions at mucosal sites. Although the pathogenic role of specific IgG and/or IgA has been already demonstrated and the detection of these immunoglobulins is a criterion in the diagnosis of MMP, little is known about IgE role in this disease. Therefore, the main purpose of this study was to assess the presence of circulating and tissue-bound IgE in patients with MMP and their possible correlations with clinical presentation and disease course. Read More
J Am Acad Dermatol 2018 Oct 5. Epub 2018 Oct 5.
Department of Quality Measurements and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel; Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.