665 results match your criteria Pemphigoid Gestationis
Dermatol Clin 2018 Jul 26;36(3):259-265. Epub 2018 Apr 26.
Division of Dermatology, Ohio State University College of Medicine, 540 Officenter Place, #240, Gahanna, OH 43230, USA. Electronic address:
Pruritus in pregnancy can be a source of significant discomfort in the pregnant patient. Some cases are associated with pregnancy-specific dermatoses, although some patients experience a flare of a preexisting dermatosis. Severe pruritus may be a manifestation of a pregnancy-specific dermatosis associated with increased fetal risks and complications. Read More
J Dtsch Dermatol Ges 2018 Jun;16(6):775-777
Department of Dermatology, Allergology and Dermatosurgery, HELIOS University Medical Center Wuppertal, University of Witten/Herdecke, Germany.
J Dtsch Dermatol Ges 2018 Jun;16(6):775-777
Zentrum für Dermatologie, Allergologie und Dermatochirurgie, HELIOS Universitätsklinikum Wuppertal, Universität Witten/Herdecke.
Acta Dermatovenerol Croat 2018 Apr;26(1):71-72
Sergio Santos-Alarcon, MD, Department of Dermatology, , Hospital Universitario Doctor Peset, Avinguda Gaspar Aguilar Nº 90, 4601 Valencia, Spain;
Dear Editor, Gestational pemphigoid (GP) is a rare autoimmune bullous dermatosis in pregnancy. GP usually occurs during the second or third month of pregnancy. It clinically manifests as the development of either early-onset urticarial lesions or late-onset subepidermal blisters that may linger for weeks or even months. Read More
Clin Cosmet Investig Dermatol 2018 24;11:187-194. Epub 2018 Apr 24.
Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Background: Autoimmune subepidermal bullous dermatoses have similar clinical features to those of a spectrum of immune reactants at the dermoepidermal junction (DEJ). It is difficult to obtain a precise diagnosis without an immunofluorescence assay because of their similar clinical presentations. The aim of this study was to describe the cellular cutaneous infiltration among autoimmune subepidermal bullous dermatoses. Read More
BMJ Case Rep 2018 Apr 7;2018. Epub 2018 Apr 7.
Department of Dermatovenereology, Hospital de Braga, Braga, Portugal.
Pemphigoid gestationis (PG), also known as , is a rare autoimmune blistering disease specific to pregnancy, which usually presents in the second or third trimesters and, in 15%-25% of cases, during the immediate postpartum period.Although the ethiopathogeny of PG is not fully clarified, most patients develop antibodies against a 180 kDa transmembrane hemidesmosomal protein (BP180; BPAG2; collagen XVII). PG has a strong association with human leucocyte antigens DR3 and DR4. Read More
J Dermatolog Treat 2018 May 7:1-4. Epub 2018 May 7.
a Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.
Pemphigoid gestationis (PG) is a rare autoimmune disease associated with pregnancy. Clinically, it presents with severe pruritus that precedes the appearance of vesiculobullous lesions. It usually begins on the trunk and spread rapidly to other parts of the body. Read More
J Cutan Med Surg 2018 Jul/Aug;22(4):435-438. Epub 2018 Feb 28.
1 Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada.
Int J Dermatol 2018 May 23;57(5):534-540. Epub 2018 Feb 23.
Immunodermatology Laboratory, Department of Dermatology, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Background: Pemphigoid (herpes) gestationis (PG) is an uncommon, self-limited disease with other autoimmune associations; however, celiac disease (CD) is not recognized as one.
Methods: From 71 patients' sera submitted for herpes gestationis factor (HGF) testing over a 5-year period, 12 were consistent with PG demonstrating HGF and increased IgG BP180 antibody levels; these sera were tested for IgA and IgG endomysial antibodies (EMA), epithelial basement membrane zone and cell surface antibodies by indirect immunofluorescence, and for IgA and IgG tissue transglutaminase (transglutaminase 2 or TG2) antibodies, IgA epidermal transglutaminase (transglutaminase 3 or TG3) antibodies, IgG BP230, and IgG desmoglein 1 and desmoglein 3 antibodies by enzyme-linked immunosorbent assays (ELISAs).
Results: Three of 12 patients' sera with PG (25%) had CD antibodies with positive IgA EMA and increased IgA TG2 antibody levels; two of these had positive IgG EMA, and one other had an increased IgA TG3 antibody level. Read More
Am J Clin Dermatol 2018 Jun;19(3):391-403
Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA.
Autoimmune bullous diseases (AIBD), including pemphigus, bullous pemphigoid, epidermolysis bullosa acquisita, mucous membrane pemphigoid, and pemphigoid gestationis, pose significant therapeutic challenges, especially in pregnant and post-partum breastfeeding patients or those planning to conceive. Data on the safety and efficacy of therapeutic interventions during the perinatal period are lacking because randomized controlled trials are typically not performed in this setting. However, many of the treatments for AIBD are also used in other diseases, so data can be extrapolated from studies or case reports in these other patient populations. Read More
JAMA Dermatol 2018 Apr;154(4):484-486
Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Acta Dermatovenerol Croat 2017 Oct;25(3):195-201
Foteini Lamprou, MD, MSc, PhD candidate, 2nd University Department of Dermatology Papageorgiou General Hospital Aristotle University of Thessaloniki, Ring Road, Municipality of Pavlos Melas, Area of N. Efkarpia, 56403 Thessaloniki, Greece;
Bullous Diseases Unit at the 2nd Department of Dermatology and Venereology, Aristotle University of Thessaloniki was founded with the aim to provide the optimal diagnostic approach and treatment of patients with autoimmune bullous diseases (AΙBD). We processed all AIBD files of patients diagnosed from 2011 to 2014 in order to record all epidemiological data and therapeutic manipulations during monitoring. 57 patients were diagnosed with intraepidermal and 62 with subepidermal bullous diseases. Read More
J Dermatol 2018 Apr 4;45(4):472-474. Epub 2017 Dec 4.
Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Subepidermal autoimmune blistering disease including bullous pemphigoid, pemphigoid gestationis, mucous membrane pemphigoid, anti-laminin-γ1 pemphigoid, linear immunoglobulin A bullous disease and epidermolysis bullosa acquisita (EBA), are all characterized by direct immunofluorescence microscopy or immunoglobulin deposition on the basement membrane zone. Among them, EBA is a rare acquired subepidermal autoimmune blistering disease of the skin and mucous membranes reactive with type VII collagen, a major component of the epidermal basement membrane zone. Anti-laminin-332-type mucous membrane pemphigoid has pathogenic autoantibodies against laminin-332, which is a basement membrane heterotrimeric protein composed of α3, β3 and γ2 laminin chains. Read More
Clin Cosmet Investig Dermatol 2017 8;10:441-449. Epub 2017 Nov 8.
Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
Many skin diseases can occur in pregnant women. However, a few pruritic dermatological conditions are unique to pregnancy, including pemphigoid gestationis (PG). As PG is associated with severe morbidity for pregnant women and carries fetal risks, it is important for the clinician to quickly recognize this disease and refer it for dermatological evaluation and treatment. Read More
Immunol Res 2018 Feb;66(1):6-17
Department of Dermatology, Rambam Health Care Campus, POB 9602, 31096, Haifa, Israel.
Subepidermal autoimmune bullous diseases of the skin and mucosae comprise a large group of chronic diseases, including bullous pemphigoid, pemphigoid gestationis, mucous membrane pemphigoid, linear IgA bullous dermatosis, epidermolysis bullosa acquisita, and anti-p200 pemphigoid. These diseases are characterized by an antibody response toward structural components of the basement membrane zone, resulting in subepidermal blistering. The epidemiological features of these diseases vary substantially in different regions of the world. Read More
Am J Dermatopathol 2018 Feb;40(2):111-117
Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA.
Direct immunofluorescence (DIF) on frozen tissue (DIF-F) is the method of choice for the identification of immune deposits present in skin and other tissues. DIF can also be performed on formalin-fixed paraffin-embedded tissue (DIF-P) after antigen retrieval with proteases and has proven to be of value in renal pathology. However, its utility in skin biopsies has not been fully examined. Read More
Clin Rev Allergy Immunol 2018 Feb;54(1):26-51
Department of Dermatology, University of Bern, Bern, Switzerland.
Autoimmune subepidermal blistering diseases of the skin and mucosae constitute a large group of sometimes devastating diseases, encompassing bullous pemphigoid, gestational pemphigoid, mucous membrane pemphigoid, epidermolysis bullosa acquisita, and anti-p200 pemphigoid. Their clinical presentation is polymorphic. These autoimmune blistering diseases are associated with autoantibodies that target distinct components of the basement membrane zone of stratified epithelia. Read More
Dermatol Ther 2017 09 21;30(5). Epub 2017 Jul 21.
Dermatology Department, Policlinico Universitario "A. Gemelli", Università Cattolica del Sacro Cuore, Rome, Italy.
Int J Womens Dermatol 2017 Jun 23;3(2):86-90. Epub 2016 Dec 23.
Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Australas J Dermatol 2018 May 19;59(2):e123-e126. Epub 2017 May 19.
Department of Neurology, Mohammed V. Rabat Military Hospital, Rabat, Morocco.
Pemphigoid gestationis is a skin-specific autoimmune disorder that can sometimes present as the cutaneous manifestation of a multiorgan disease due to potentially common pathogenic mechanisms. We report a severe form of pemphigoid gestationis in a 32-year-old primigravida woman, who presented at 22 weeks of gestation with headaches and blurred vision, later developing encephalitis, intrauterine fetal demise and dilated cardiomyopathy. Read More
Br J Dermatol 2017 04;176(4):e36
Department of Dermatology, Dankook University College of Medicine, San 16-5, Anseo dong, Cheonan, Chungnam, Republic of Korea.
J Obstet Gynaecol 2017 Aug 11;37(6):824-826. Epub 2017 Apr 11.
a Department of Obstetrics and Gynecology , University Hospital Martin and Jessenius Faculty of Medicine, Comenius University , Martin , Slovakia.
BMJ 2017 03 9;356:j968. Epub 2017 Mar 9.
Tunbridge Wells Hospital, Tunbridge Wells, UK.
Interv Med Appl Sci 2016 Mar;8(1):20-22
Department of Obstetrics and Gynecology, Ankara Numune Education and Research Hospital , Ankara , Turkey.
Pemphigoid gestationis (PG) is a rare autoimmune blistering disease of pregnancy caused by antibasement membrane zone auto-antibodies. The usual clinical findings are multiple pruritic urticarial papules and plaques, target lesions, vesicles, and blisters that occur during the second and third trimesters of pregnancy or in the immediate postpartum period. The disease is often treated with topical corticosteroids and oral antihistaminics. Read More
J Am Acad Dermatol 2017 Mar;76(3):560-562
Department of Dermatology, INSERM U1234, Rouen University Hospital, University of Rouen, France. Electronic address:
Acta Dermatovenerol Croat 2016 Dec;24(4):307-309
Prof. Magdalena Czarnecka-Operacz, MD, PhD, Department of Dermatology, 49 Przybyszewski Str., 60-355 Poznań, Poland.
Dear Editor, Erythema multiforme is considered an acute skin condition, characterized by a self-limiting and sometimes recurrent course. It is regarded as a type IV hypersensitivity reaction associated with certain infections, medications, and other various triggers. Allergic contact dermatitis is in turn a delayed type of induced allergy as a result of cutaneous contact with a specific allergen to which the patient develops specific sensitivity. Read More
Semin Diagn Pathol 2017 May 14;34(3):250-260. Epub 2016 Dec 14.
Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Charlottesville, VA, United States. Electronic address:
Several dermatoses are typified by the formation of spaces (blisters; bullae) within or beneath the epidermis. These may be acellular or filled with particular species of inflammatory cells. Etiological categories include infectious, immune-mediated, genetic, drug-related, and idiopathic lesions. Read More
Int J Dermatol 2017 Mar 11;56(3):327-329. Epub 2017 Jan 11.
Chairs of Dermatology and Immunology, Instituto Nacional de Dermatología (now Instituto de Biomedicina,"Jacinto Convit"), Vargas School of Medicine, Central University of Venezuela, Caracas, Venezuela.
Hautarzt 2017 Feb;68(2):87-94
Hautklinik, Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Deutschland.
The specific dermatoses of pregnancy represent a heterogeneous group of inflammatory skin diseases related to pregnancy and/or the postpartum period. A clinically relevant classification has been well established over the past 10 years and includes pemphigoid gestationis, polymorphic eruption of pregnancy, intrahepatic cholestasis of pregnancy, and atopic eruption of pregnancy. The hallmark of all four entities is severe pruritus that is accompanied by characteristic skin changes. Read More
J Obstet Gynaecol 2017 Feb 14;37(2):137-140. Epub 2016 Dec 14.
a Department of Obstetrics and Gynaecology , Centro Hospitalar Tâmega e Sousa, Hospital Padre Américo , Penafiel , Portugal.
Polymorphic Eruption of Pregnancy (PEP) is one of the most common dermatosis related to pregnancy. PEP usually consists of pruritic papules and plaques appearing in the third trimester of pregnancy. It is more common in primigravidae and twin pregnancies. Read More
J Obstet Gynaecol 2017 Feb 6;37(2):246-247. Epub 2016 Dec 6.
a Department of Obstetrics and Gynaecology. Maternal-Fetal Medicine Unit , Universitary La Paz Hospital , Madrid , Spain.
J Clin Diagn Res 2016 Jul 1;10(7):QD06-7. Epub 2016 Jul 1.
Senior Specialist, Department of Obstetrics and Gynecology, Babu Jagjivan Ram Hospital , Delhi, India .
Pemphigoid Gestationis (PG) is a rare autoimmune blistering disease with an incidence of 1/50000 pregnancies. Presentation in the second or third trimester is most common and tends to recur in subsequent pregnancies with earlier onset and a more severe course. Direct Immunofluorescence (DIF) staining is confirmatory on skin biopsy specimen. Read More
Dermatol Online J 2016 Apr 18;22(4). Epub 2016 Apr 18.
Department of Dermatology, University of California San Diego.
Background: Bullous impetigo results from Staphylococcus aureus (S. aureus) release of exfoliative toxins type A and type B thatresults in flaccid, easily ruptured, bullae in the upper layers of the epidermis. Physiologic, gestation-associated, and incidental skin changes can occur in pregnancy. Read More
J Eur Acad Dermatol Venereol 2017 Apr 30;31(4):e206-e207. Epub 2016 Sep 30.
Department of Dermatology, Bichat Claude Bernard Hospital, Paris, France.
Curr Probl Dermatol 2016 23;50:164-72. Epub 2016 Aug 23.
Department of Dermatology, University Hospital of Antwerp, University of Antwerp, Edegem, Belgium.
Pruritus is common in pregnancy. It deserves an elaborated work-up of the patient. It is frequently a symptom of a dermatosis that coincides by chance with pregnancy or a preexisting dermatosis that can flare during pregnancy. Read More
J Invest Dermatol 2016 12 25;136(12):2495-2498. Epub 2016 Jul 25.
Department of Dermatology, University of Lübeck, Lübeck, Germany; Lübeck Institute of Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany. Electronic address:
Cutis 2016 Jun;97(6):E20-4
Department of Dermatology, University of Puerto Rico School of Medicine, Río Piedras.
Lichen planus pemphigoides (LPP) is a rare condition characterized by tense blisters that arise on lesions of lichen planus (LP) and on unaffected skin. We present the case of a 25-year-old pregnant woman at 12 weeks' gestation who developed an acute bullous eruption after 5 months of worsening LP. Similarities to pemphigoid gestationis (PG) included lesions around the periumbilical area and multiple urticarial erythematous papules and plaques in addition to linear C3 and IgM deposition along the basement membrane zone (BMZ) on direct immunofluorescence (DIF). Read More
Clin Dermatol 2016 May-Jun;34(3):383-91. Epub 2016 Feb 9.
Department of Dermatology, University of Illinois at Chicago College of Medicine, Chicago, Illinois.
Polymorphic eruption of pregnancy (PEP), a specific dermatosis of pregnancy also known as pruritic urticarial papules and plaques of pregnancy (PUPPP), is a benign, self-limited skin disorder. Key features include an increased prevalence in primigravidas, onset in the third trimester, remission near the time of delivery, and association with multiple gestation pregnancy. The clinical features are crucial to diagnosis. Read More
Clin Dermatol 2016 May-Jun;34(3):378-82. Epub 2016 Feb 9.
Department of Dermatology, Allergy, and Venereology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
Pemphigoid gestationis (PG) is the only autoimmune disease exclusively emerging in pregnancy. It belongs to the pemphigoid group of disorders, a class of autoimmune blistering skin diseases featuring an immune response against different hemidesmosomal proteins. PG is caused by a break of immunotolerance against the hemidesmosomal protein BP180. Read More
Clin Dermatol 2016 May-Jun;34(3):320-6. Epub 2016 Feb 10.
Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address:
This review presents the approach of the obstetric medicine physician to skin disease in pregnancy. It elaborates on common skin-related problems during gestation, such as pruritus, with or without eruption, and drug eruptions. An algorithmic approach to the differential diagnosis of pruritus in pregnancy is outlined. Read More
Clin Dermatol 2016 May-Jun;34(3):314-9. Epub 2016 Feb 9.
Department of Dermatology, University of California School of Medicine, San Francisco, California; Department of Dermatology, Palo Alto Foundation Medical Group, Mountain View, California. Electronic address:
The most recent reclassification of dermatoses of pregnancy includes polymorphic eruption of pregnancy, atopic eruption of pregnancy, and pemphigoid gestationis; intrahepatic cholestasis of pregnancy, strictly not a dermatosis, was included in specific dermatoses of pregnancy for working purposes. Another dermatosis, pustular psoriasis of pregnancy, could be included for similar reasons. The nomenclature of these pregnancy-specific eruptions has been revised several times, generating potential confusion among practitioners. Read More
Ann Dermatol Venereol 2016 Jun-Jul;143(6-7):483-5. Epub 2016 May 24.
Service de dermatologie, hôpital universitaire de Saint-Etienne, 42055 Saint-Étienne cedex 2, France.
J Reprod Immunol 2016 08 4;116:42-5. Epub 2016 May 4.
Dermatology residents, Saudi commission of health programs, Saudi Arabia.
Background And Objectives: Pemphigoid gestationis (PG) is a rare autoimmune-mediated blistering disease that mainly affects pregnant women in their 2nd or 3rd trimester and immediate postpartum period. In addition to the clinical assessment, the diagnosis of PG is usually confirmed by histological and immunological studies. PG usually flares up at the time of delivery and spontaneously improves postpartum. Read More
Acta Derm Venereol 2017 01;97(1):128-130
Department of Dermatology, Allergy, and Venereology, University of Lübeck, DE-23538 Lübeck, Germany.
Turk Patoloji Derg 2016 ;32(2):91-8
Department of Pathology Bharati Vidyapeeth Deemed University Medical College and Hospital, SANGLI, INDIA.
Objective: Sub-epidermal bullous disorders belong to immunobullous diseases which develop as a result of autoantibody action against epidermal basement membrane proteins. Clinically, they are tense bullae and do not rupture easily. They are classified into various forms based on histopathology and direct immunofluorescence patterns. Read More
Indian J Dermatol Venereol Leprol 2016 May-Jun;82(3):358
Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Background: The subepidermal autoimmune bullous diseases are a subset of immunobullous diseases encountered less frequently in the Indian population. There is a paucity of data on the prevalence, demographic and clinicopathological spectrum of various subepidermal autoimmune bullous diseases from India.
Aim: To determine the demographic and clinicopathological profile of subepidermal autoimmune bullous diseases in Indian patients, presenting to the Immunobullous Disease Clinic of Postgraduate Institute of Medical Education and Research, Chandigarh. Read More
Dermatol Online J 2016 Jan 15;22(1). Epub 2016 Jan 15.
Baylor College of Medicine.
Pemphigus and pemphigoid are two unique acquired immunobullous diseases with distinct clinical presentations, histological findings, and characteristic serology; they are rarely reported to coexist in the same patient. Herein we present a 29-year-old woman with a history of pemphigus vulgaris, diagnosed by histology and positive desmoglein-3 antibodies on ELISA. She presented to our clinic shortly after the delivery of her first child with tense vesicles and bullae on an erythematous base on her abdomen. Read More