Search Our Scientific Publications & Authors

J Sex Med 2022 May 11. Epub 2022 May 11.

Amsterdam UMC, University of Amsterdam, Department of Obstetrics and Gynaecology, Amsterdam Reproduction and Development research institute, Amsterdam, The Netherlands; Bergman Clinics, Department of Gynaecology, Bergman Vrouwenzorg, Amsterdam, The Netherlands.

Background: Peri-urethral bulking injections (PBI) gain popularity for the treatment of stress urinary incontinence (SUI), but - in contrast to mid-urethral sling (MUS) surgery - little is known about its impact on sexual function.

Methods: This was a secondary analysis of a prospective cohort study that included patients with moderate to severe SUI undergoing either MUS surgery or PBI with polydimethylsiloxane Urolastic (PDMS-U). The validated Dutch and English version of the 'Pelvic Organ Prolapse and/or Urinary Incontinence Sexual Function Questionnaire - IUGA Revised' (PISQ-IR) was used to assess sexual function at baseline, at 6 and 12 months of follow-up. Read More

Am J Obstet Gynecol 2022 May 11. Epub 2022 May 11.

Division of Female Pelvic Medicine and Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL.

Background: Symptomatic pelvic organ prolapse is common and affects 25% - 35% of women worldwide. As this growing patient need is being met by surgeons from diverse training backgrounds, it is important to both characterize differences in surgeon practice patterns and examine postoperative outcomes to ensure optimal patient care.

Objective: To determine the association between surgeon specialty and postoperative outcomes following surgery for pelvic organ prolapse. Read More

Int J Environ Res Public Health 2022 May 5;19(9). Epub 2022 May 5.

Department of Obstetrics and Gynecology, Peking University People's Hospital, No. 11, Xi-Zhi-Men South Street, Xi Cheng District, Beijing 100044, China.

Introduction: The incidence of urinary incontinence (UI) increases with age. Mild and moderate UI have little impact on women and are easily ignored. This study reports the characteristics of non-severe UI and quality of life (QOL) in elderly women using data from a Development and Evaluation of a Senile UI Alert System study. Read More

Int J Environ Res Public Health 2022 Apr 24;19(9). Epub 2022 Apr 24.

Department of Obstetrics & Gynecology, Cumming School of Medicine, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada.

Pelvic Organ Prolapse (POP) occurs when one or more pelvic organs descend into or through the vaginal opening, significantly impacting physical and mental health. POP affects the female reproductive tract and, overwhelmingly, people who identify as women. However, little research has examined the impact of gendered expectations on women's treatment-seeking for POP and their decision-making around surgery for POP. Read More

BMC Womens Health 2022 May 13;22(1):164. Epub 2022 May 13.

Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Kita 15 Nishi 7; Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.

Background: It has been hypothesized that women with significant pelvic organ prolapse (POP), particularly of the anterior vaginal wall, may have voiding dysfunction (VD). Although the VD mechanism due to cystocele is not fully understood, different vaginal compartments have rarely been closely examined. This study attempted to further elucidate the correlation between POP and VD through a new subgroup classification using cystoscopy. Read More

Womens Health Rep (New Rochelle) 2022 11;3(1):430-436. Epub 2022 Apr 11.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Objective: Tamoxifen complicates management of conditions such as urinary tract infections (UTIs), urinary incontinence (UI), and/or pelvic organ prolapse (POP) that traditionally benefit from hormonal intake; thus, we reviewed our experience in managing these hormonally deprived women.

Materials And Methods: After IRB approval, electronic medical records from women with current use or history of tamoxifen use and referred to a tertiary care center with female pelvic medicine and reconstructive surgery expertise for UTI, UI, and/or POP were reviewed.

Results: From 2015 to 2020, 32 women treated with tamoxifen 10-40 mg for a median of 4 years were referred for UTIs (9), UI (10), symptomatic POP (8), or for a combination of these (5). Read More

Front Surg 2022 26;9:878760. Epub 2022 Apr 26.

Department of Surgery, Azienda ospedaliero-Universitaria Policlinico di Modena, Modena, Italy.

Introduction: Vaginal evisceration is an extremely rare surgical emergency that can be described as the extrusion of abdominal viscera through a defect or a rupture of the vaginal wall. We reported the case of an acute abdomen due to small bowel evisceration secondary to vaginal vault dehiscence that required combined vaginal-abdominal approach.

Case: We discuss the case of a 72-year-old female who presented to the emergency department for a large prolapse with visible extrusion of the small bowel per vagina. Read More

Transl Androl Urol 2022 Apr;11(4):554-560

Department of Urology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.

Background: Owing to its tediousness and monotony, traditional pelvic floor muscle training (PFMT) is difficult to ensure the correctness of exercise, and it is difficult for patients to adhere to treatment. We designed this study to evaluate and analyze the efficacy of optimized pelvic floor training of YUN combined with pelvic floor magnetic stimulation on female moderate stress urinary incontinence (SUI) and sexual function.

Methods: This is a retrospective cohort study. Read More

Biomater Sci 2022 May 13. Epub 2022 May 13.

The University of Queensland, School of Mechanical and Mining Engineering, Centre for Advanced Materials Processing and Manufacturing (AMPAM), St Lucia, Qld, 4072, Australia.

Pelvic organ prolapse is the herniation of surrounding tissue and organs into the vagina and/or rectum and is a result of the weakening of pelvic floor muscles, connective tissue, and fascia. It is widely accepted that 50% of women will develop prolapse, with the prevalence increasing with age, and up to 10-20% of those seek evaluation for their condition. Suture repairs of pelvic floor defects are associated with a high failure rate, and permanent meshes were introduced to reduce the recurrence rate. Read More

J Am Coll Radiol 2022 May;19(5S):S137-S155

Associate Chair for Ambulatory Care and Specialty Chair, University of Michigan, Ann Arbor, Michigan.

Pelvic floor disorders including pelvic organ prolapse (POP), urinary dysfunction, defecatory dysfunction, and complications after pelvic floor surgery are relatively common in the female population. Imaging tests are obtained when the initial clinical evaluation is thought to be incomplete or inconclusive or demonstrates findings that are discordant with patients' symptoms. An integrated imaging approach is optimal to evaluate the complex anatomy and dynamic functionality of the pelvic floor. Read More

Am J Obstet Gynecol 2022 May 9. Epub 2022 May 9.

Department of Urogynecology, TriHealth, Cincinnati, OH.

Background: Patients undergoing vaginal hysterectomy with native tissue pelvic reconstruction typically have low pain levels overall in the postoperative period. Notwithstanding, pain control immediately following surgery may be more challenging and a barrier to same-day discharge. Intrarectal diazepam has been utilized for acute and chronic pelvic pain and has a pharmacokinetic profile ideal for intermittent use. Read More

Front Med (Lausanne) 2022 25;9:878815. Epub 2022 Apr 25.

Department of Gynecology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Background: Hysterectomy is one of the most frequently performed operations worldwide. However, postoperative complications and body image changes may induce psychological distress after hysterectomy. The study aimed to evaluate the effect of psychological intervention on pelvic floor function and psychological outcomes following hysterectomy among patients with benign indications. Read More

Female Pelvic Med Reconstr Surg 2022 May 5. Epub 2022 May 5.

Division of Urogynecology, Department of Obstetrics & Gynecology, Duke University, Durham, NC.

Importance: There are no publications on national trends in performance of concomitant stress urinary incontinence (SUI) treatment with pelvic organ prolapse surgery over the past decade.

Objectives: The objective of this study was to describe trends in the performance and type of concomitant SUI treatment from 2011 to 2019.

Study Design: Surgical procedures for pelvic organ prolapse and coding for prolapse repair were identified from the American College of Surgeons National Surgical Quality Improvement Program database. Read More

Biomater Sci 2022 May 11. Epub 2022 May 11.

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.

Pelvic organ prolapse (POP) harms the quality of life of elderly patients. Transvaginal polypropylene mesh repair for POP was a frequently reported complication and was banned by the FDA in 2019. New therapeutic strategies are urgently required, and tissue engineering technology could be a novel therapy. Read More

Int Urogynecol J 2022 May 10. Epub 2022 May 10.

Department of Urogynaecology, Women's and Newborn Services, Royal Brisbane and Women's Hospital, Brisbane, Australia.

Introduction And Hypothesis: Levator ani muscle avulsion as a risk factor for prolapse recurrence is not well established. This systematic review was aimed at evaluating the correlation between levator ani avulsion and postoperative prolapse recurrence with meta-analysis, specifically, the risk of subjective or objective prolapse recurrence and reoperation.

Methods: The protocol was registered in the International Prospective Register of Systematic Reviews (registration number CRD42021256675). Read More

Female Pelvic Med Reconstr Surg 2022 Apr 24. Epub 2022 Apr 24.

Department of Obstetrics and Gynecology, Ministry of Health Ankara City Hospital, Ankara, Turkey.

Importance: Currently, apical prolapse is diagnosed via assessing the levels of C and D points in the pelvic organ prolapse quantification (POP-Q) system. However, it is not yet known whether the other components of this system are useful for diagnosing apical prolapse and its symptoms.

Objective: The aim of the study was to evaluate the association between the perineal body size (PB), total vaginal length (TVL), and apical prolapse and its symptoms. Read More

Female Pelvic Med Reconstr Surg 2022 Apr 24. Epub 2022 Apr 24.

From the Georgetown University School of Medicine/MedStar Health, Washington, DC.

Importance: Data on long-term mesh hysteropexy outcomes are limited. This study provides 7-year data from the original VAULT (Vaginal and Laparoscopic Mesh Hysteropexy for Uterovaginal Prolapse Trial) study.

Objective: The aim of this study was to compare long-term outcomes and success for laparoscopic sacral hysteropexy (LSHP) and vaginal mesh hysteropexy (VMHP). Read More

Open Med (Wars) 2022 22;17(1):801-807. Epub 2022 Apr 22.

Department of Gynecology and Obstetrics, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan, China.

The objective of this study was to compare the clinical effectiveness of traditional vaginal surgery and transvaginal mesh (TVM) surgery on severe pelvic organ prolapse (POP). We performed a retrospective chart review study of 258 severe POP patients who underwent surgery between November 2010 and September 2016. One hundred forty patients underwent traditional vaginal surgery and 118 TVM surgery. Read More

J Mech Behav Biomed Mater 2022 Apr 25;131:105249. Epub 2022 Apr 25.

Department of Biomedical Engineering and Mechanics, Virginia Tech, 330A Kelly Hall, 325 Stanger Street, Blacksburg, VA, 24061, USA. Electronic address:

The uterosacral ligaments (USLs) are supportive structures of the uterus and apical vagina. The mechanical function of these ligaments within the pelvic floor is crucial not only in normal physiological conditions but also in reconstructive surgeries for pelvic organ prolapse. Discrepancies in their anatomical and histological description exist in the literature, but such discrepancies are likely due to large variations of these structures. Read More

Mater Today Bio 2022 Jun 19;15:100268. Epub 2022 Apr 19.

Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam Institute for Infection and Immunity, Meibergdreef 9, Amsterdam, the Netherlands.

Polypropylene (PP) implants for the vaginal surgical correction of pelvic organ prolapse (POP) are known for adverse events, like vaginal or visceral exposures. It is hypothesized that this is a result of a prolonged inflammatory response. One of the triggering factors of prolonged inflammation might be bacterial contamination. Read More

Sci Rep 2022 05 5;12(1):7320. Epub 2022 May 5.

Department of Gynaecology, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, China.

Defecation disorder is one of the main symptoms in pelvic organ prolapse (POP) patients. Our study aims to translate the Chinese version of the constipation scoring system (CSS) questionnaire and test the reliability and validity of its application in Chinese POP women. We recruited 140 women suffering prolapse with stage II or above POP who reported at least one abnormal defecation symptom. Read More

Urol Int 2022 May 5:1-9. Epub 2022 May 5.

School of Engineering and Mathematical Sciences, University of Western Australia, Perth, Washington, Australia.

Background: The posterior fornix syndrome (PFS) was first described in 1993 as a predictably occurring group of symptoms: chronic pelvic pain (CPP), urge, frequency, nocturia, emptying difficulties/urinary retention, caused by uterosacral ligament (USL) laxity, and cured by repair thereof.

Summary: Our hypothesis was that non-Hunner's interstitial cystitis (IC) and PFS are substantially equivalent conditions. The primary objective was to determine if there was a causal relationship between IC and pelvic organ prolapse (POP). Read More

Int Urogynecol J 2022 May 5. Epub 2022 May 5.

Department of Obstetrics and Gynecology, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.

Introduction And Hypothesis: Pelvic organ prolapse is among the most common gynecologic problems worldwide. It greatly influences women's quality of life. However, research regarding the effect of pelvic organ prolapse on quality of life is limited in our study area. Read More

Int J Womens Health 2022 28;14:625-633. Epub 2022 Apr 28.

Department of Obstetrics and Gynecology, Mbarara University of Science and Technology, Mbarara, Uganda.

Purpose: To determine the prevalence, clinical stage at presentation and factors associated with pelvic organ prolapse (POP) among women attending the gynecology outpatient clinic at Mbarara Regional Referral Hospital (MRRH), Uganda.

Methods: We conducted a cross-sectional study at the gynecology outpatient clinic of MRRH from September 2019 to January 2020. Women aged 18-90 years were systematically sampled and recruited into this study. Read More

Comput Math Methods Med 2022 25;2022:1786994. Epub 2022 Apr 25.

Settlement Center, Hunan Maternal and Child Health Hospital, Changsha, 410008 Hunan, China.

This study was aimed at exploring the application value of ultrasound technology and rehabilitation training based on artificial intelligence algorithm in postpartum recovery of pelvic organ prolapse. Sixty patients diagnosed as mild and moderate pelvic organ prolapse by pelvic organ prolapse quantification evaluation were selected as the research objects. The patients were randomly divided into experimental group (30 cases) and control group (30 cases). Read More

BMC Surg 2022 May 4;22(1):157. Epub 2022 May 4.

Department of General Surgery, Unit of Gastrointestinal, Hepato-Biliary and Pancreatic Surgery, University Hospital "Alexandrovska", Sofia, Medical University of Sofia, 1 G.Sofiiski Str., 1431, Sofia, Bulgaria.

Background: Transvaginal intestinal evisceration is an extremely rare surgical emergency with potentially fatal consequences. Only a few more than 100 cases with this pathology have been described in the literature. Aetiology is also unclear and multifactoral. Read More

J Obstet Gynaecol 2022 May 3:1-6. Epub 2022 May 3.

Centre for Advanced Reproductive Endosurgery (C.A.R.E.), Sydney, NSW, Australia.

This study aims to review the surgical complications and mesh erosion with a cohort of patients who underwent Elevate™ mesh repair. This was a single-centre, retrospective study of women undergoing Elevate™ mesh reconstruction between 2006 and 2016. Women who presented with symptomatic prolapse of stage II or above were enrolled. Read More

Int Urogynecol J 2022 May 3. Epub 2022 May 3.

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.

Introduction And Hypothesis: The objective was to test the hypotheses that a linear relationship exists between age and levator bowl volume (LBV); and that age, parity, and prolapse are independently associated with LBV.

Methods: We conducted a secondary analysis of data from nulliparous women, parous controls, and prolapse (Pelvic Organ Prolapse Quantification (POP-Q) Ba ≥ 1 cm) cases from each of three age groups: young (≤40), mid-age (50-60), and older (≥70). LBV was measured using MRI at rest and Valsalva as the 3D space contained above the levator ani muscles and below the sacrococcygeal junction-to-inferior pubic point reference plane. Read More

Int Urogynecol J 2022 May 2. Epub 2022 May 2.

Department of Surgery, Division of Gynecologic Oncology, City of Hope Comprehensive Cancer Center, 1500 E. Duarte Road, Duarte, CA, 91010, USA.

Introduction And Hypothesis: At our institution, every patient seen by the gynecologic oncology service is screened for pelvic floor dysfunction. This study was aimed at determining if a combined surgical approach by gynecologic oncology and urogynecology services at our institution was feasible and safe for this patient population.

Methods: We performed a retrospective review of patients undergoing combined surgery by gynecologic oncology and urogynecology services at our institution from 2013 to 2021. Read More

Int Urogynecol J 2022 May 2. Epub 2022 May 2.

Department of Obstetrics, Gynaecology & Neonatology, Sydney Medical School Nepean, University of Sydney, 62 Derby Street, Kingswood, NSW, 2747, Australia.

Introduction And Hypothesis: Staging of pelvic organ prolapse (POP) is important in clinical practice and research. Pelvic organ descent on Valsalva can be confounded by levator co-activation, which may be avoided by assessment on coughing. We evaluated the performance of a three consecutive coughs maneuver in the assessment of POP compared with standardised 6-second Valsalva. Read More