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    Protective effects of apigenin on LPS-induced endometritis via activating Nrf2 signaling pathway.
    Microb Pathog 2018 Jun 18. Epub 2018 Jun 18.
    Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China. Electronic address:
    Endometritis is a puzzling disease that often associates with severe pelvic pain. In this study, we aimed to detect whether apigenin had protective effect against LPS-induced endometritis, if so, the underlying mechanism was further investigated. Apigenin was administrated 1 h before LPS treatment. Read More

    Review of current practice and outcomes following ileoanal pouch surgery: Lessons learned from the Ileoanal Pouch Registry and the 2017 Ileoanal Pouch Report.
    Colorectal Dis 2018 Jun 21. Epub 2018 Jun 21.
    St Mark's Hospital and Academic Institute, London North West University Healthcare NHS Trust, Middlesex, UK, HA1 3UJ, United Kingdom.
    Introduction: The second ACPGBI Ileoanal Pouch Registry (IPR) report was released in July 2017 following a first report in 2012. This article provides a summary of data derived from the most recent IPR report (1).

    Method: The IPR is an electronic database of voluntarily submitted data including patient demographics, disease, intra and post-operative factors submitted by consultant surgeons or delegates. Read More

    Safety and efficacy of tigecycline in complicated and uncomplicated pelvic inflammatory disease.
    Eur Rev Med Pharmacol Sci 2018 Jun;22(11):3595-3601
    2nd Unit Obstetrics and Gynecology Santa Chiara University Hospital, Pisa, Italy.
    Objective: Tigecycline is a glycylcycline antimicrobial structurally related to minocycline, with a wide spectrum of activity that includes anaerobes and typical and atypical microorganisms causing pelvic inflammatory disease (PID). This study aimed to evaluate efficacy and safety of tigecycline in complicated PID and un-complicated PID after the failure of first-line antibiotic therapy.

    Patients And Methods: Between May 2014 and April 2016 at the 2nd Unit of Obstetrics and Gynecology, Santa Chiara Hospital of Pisa a pilot study on 20 women with mild/moderate PID after the failure of first-line antibiotic therapy and on 8 women with complicated PID was conducted. Read More

    Endocervical and Neutrophil Lipoxygenases Coordinate Neutrophil Transepithelial Migration to Neisseria Gonorrhoeae.
    J Infect Dis 2018 Jun 13. Epub 2018 Jun 13.
    Department of Microbiology, Immunology, and Cancer Biology University of Virginia, Charlottesville, VA, USA.
    Background: Infection with Neisseria gonorrhoeae (Ngo) is characterized by robust neutrophil influx that is insufficient to clear the bacteria. Sustained neutrophilic inflammation contributes to serious clinical sequelae that particularly affect women, including pelvic inflammatory disease and infertility.

    Methods: We established a three-component system using Ngo, End1 polarized human endocervical cells, and primary human neutrophils to investigate neutrophil transepithelial migration following infection. Read More

    Predictors of positive F-FDG PET/CT-scan for large vessel vasculitis in patients with persistent polymyalgia rheumatica.
    Semin Arthritis Rheum 2018 May 18. Epub 2018 May 18.
    Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain; University of Cantabria, School of Medicine, Santander, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address:
    Objective: Polymyalgia rheumatica (PMR) is often the presenting manifestation of giant cell arteritis (GCA). Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) scan often discloses the presence of large vessel vasculitis (LVV) in PMR patients. We aimed to identify predictive factors of a positive PET/CT scan for LVV in patients classified as having isolated PMR according to well-established criteria. Read More

    Glycosylation-dependent galectin-receptor interactions promote infection.
    Proc Natl Acad Sci U S A 2018 Jun 11. Epub 2018 Jun 11.
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, C1428ADN Buenos Aires, Argentina;
    () constitutes the most prevalent sexually transmitted bacterium worldwide. Chlamydial infections can lead to severe clinical sequelae including pelvic inflammatory disease, ectopic pregnancy, and tubal infertility. As an obligate intracellular pathogen, has evolved multiple strategies to promote adhesion and invasion of host cells, including those involving both bacterial and host glycans. Read More

    Pyosalpinx complicating chronic hydrosalpinx in a 50-year old virgo woman: a case report.
    BMC Womens Health 2018 Jun 11;18(1):90. Epub 2018 Jun 11.
    Department of Obstetric and Gynecology, Ospedale Regionale Bellinzona e Valli, 6500, Bellinzona, Switzerland.
    Background: Pelvic inflammatory disease is an infection of the upper genital tract, including the uterus, ovaries, uterine tubes, and pelvic peritoneum. Tubo-ovarian abscess and pyosalpinx are common complications associated with pelvic inflammatory disease. They are usually encountered in sexually active women, but rare cases in Virgos have also been described. Read More

    Complicated clinical course and poor reproductive outcomes of women with tuboovarian abscess following fertility treatments.
    J Minim Invasive Gynecol 2018 Jun 8. Epub 2018 Jun 8.
    Lis Maternity Hospital, Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. Electronic address:
    Objective: To assess the clinical course, surgical and fertility outcomes of patients diagnosed with tuboovarian abscess (TOA) following fertility treatment.

    Design: Parallel case series over 10 consecutive years.

    Design Classification: Canadian Task Force classification II-2. Read More

    Independent predictors of survival in endometrium cancer: platelet-to-lymphocyte ratio and platelet/neutrophil/monocyte-to-lymphocyte ratio
    J Turk Ger Gynecol Assoc 2018 Jun;19(2):78-86
    Department of Gynecologic Oncology, University of Health Sciences, Etlik Zübeyde Hanım Women’s Diseases Training and Research Hospital, Ankara, Turkey
    Objective: To evaluate the association between ratios of inflammatory markers and survival in endometrium cancer (EC).

    Material And Methods: Four hundred ninety-seven patients with epithelial EC were included. The evaluated ratios were neutrophil (N)/lymphocyte (L), neutrophil count divided by the lymphocyte count; platelet (P)/lymphocyte, platelets divided by the lymphocyte count; lymphocyte/monocyte (M), lymphocytes divided by the monocyte count; NM/L, neutrophil plus monocyte divided by the lymphocyte count; PNM/L, the sum total counts of platelets, neutrophils and monocytes divided by the lymphocyte count. Read More

    Sacral chordoma : A review of literature.
    J Orthop 2018 Jun 2;15(2):679-684. Epub 2018 May 2.
    Consultant Spine Unit, King Dinuzulu Hospital, Durban, South Africa.
    Chordoma is a rare malignant tumor with predilection for the sacrum. A favorable outcome depends on early diagnosis and surgical excision with tumor free margins.

    Aim: To review the incidence and prevalence of sacral chordoma and the appropriate surgical management and formulate a criteria for early diagnosis. Read More

    Appraisal of clinical complications after 23,827 oocyte retrievals in a large assisted reproductive technology program.
    Fertil Steril 2018 Jun 2. Epub 2018 Jun 2.
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut.
    Objective: To assess complications encountered after transvaginal oocyte retrieval procedures.

    Design: Retrospective analysis.

    Setting: University hospital, fertility center. Read More

    Repeat Chlamydia Diagnoses Increase the Hazard of Pelvic Inflammatory Disease among U.S. Army females: A Retrospective Cohort Analysis.
    Sex Transm Dis 2018 Jun 4. Epub 2018 Jun 4.
    Armed Forces Health Surveillance Branch, Public Health Division, Defense Health Agency, Silver Spring, Maryland.
    Background: In the U.S. military, chlamydia is the mostly commonly diagnosed bacterial sexually transmitted infection and the rates of pelvic inflammatory disease (PID) have remained high since the early 2000s. Read More

    Smoking and Inflammatory Bowel Disease: A Comparison of China, India, and the USA.
    Dig Dis Sci 2018 Jun 4. Epub 2018 Jun 4.
    Division of Gastroenterology and Hepatology, Gastrointestinal Epidemiology Research Center, Johns Hopkins University, 600 N Wolfe St, Blalock 449, Baltimore, MD, 21287, USA.
    Background: Cigarette smoking is thought to increase the risk of Crohn's disease (CD) and exacerbate the disease course, with opposite roles in ulcerative colitis (UC). However, these findings are from Western populations, and the association between smoking and inflammatory bowel disease (IBD) has not been well studied in Asia.

    Aims: We aimed to compare the prevalence of smoking at diagnosis between IBD cases and controls recruited in China, India, and the USA, and to investigate the impact of smoking on disease outcomes. Read More

    A 41-Year-Old Patient with a Rare Cause of Severe Abdominal Sepsis Misdiagnosed as PID.
    Case Rep Surg 2018 10;2018:9561798. Epub 2018 Apr 10.
    Department of Surgery, Dunedin University Hospital, Dunedin, New Zealand.
    Infectious pelvic inflammatory disease is a common condition and a frequent cause of abdominal pain in a young female patient. In a patient who has not completed family planning, the diagnosis is often made with a low threshold and treatment started on a low suspicion of diagnosis to avoid a negative impact on fertility. Here, we present a case of a 41-year-old woman who was misdiagnosed with infectious pelvic inflammatory disease and treated ineffectively with antibiotics when the underlying condition of her persistent abdominal pain was a midgut neuroendocrine tumor that had caused bowel perforation and formation of an abscess in the pouch of Douglas. Read More

    Does muscle biopsy change the treatment of pediatric muscular disease?
    Pediatr Surg Int 2018 Jul 29;34(7):797-801. Epub 2018 May 29.
    Department of Surgery, The Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO, 64108, USA.
    Background: Muscle biopsy is performed to confirm the diagnosis of neuromuscular disease and guide therapy. The purpose of our study was to determine if muscle biopsy changed patient diagnosis or treatment, which patients were most likely to benefit from muscle biopsy, and complications resulting from muscle biopsy.

    Materials And Methods: An IRB-approved retrospective chart review of all patients less than 18 years old undergoing muscle biopsy between January 2010 and August 2016 was performed. Read More

    The microbiome in prostate inflammation and prostate cancer.
    Prostate Cancer Prostatic Dis 2018 May 23. Epub 2018 May 23.
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Background: The human microbiome may influence prostate cancer initiation and/or progression through both direct and indirect interactions. To date, the majority of studies have focused on direct interactions including the influence of prostate infections on prostate cancer risk and, more recently, on the composition of the urinary microbiome in relation to prostate cancer. Less well understood are indirect interactions of the microbiome with prostate cancer, such as the influence of the gastrointestinal or oral microbiota on pro- or anti-carcinogenic xenobiotic metabolism, and treatment response. Read More

    Antibodies Against Chlamydia trachomatis and Ovarian Cancer Risk in Two Independent Populations.
    J Natl Cancer Inst 2018 May 21. Epub 2018 May 21.
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.
    Background: Pelvic inflammatory disease (PID) has been associated with ovarian cancer risk. To clarify the role of Chlamydia trachomatis and other infectious agents in the development of ovarian cancer, we evaluated the association of serologic markers with incident ovarian cancer using a staged approach in two independent populations.

    Methods: Studies included: 1) a case-control study in Poland (244 ovarian cancers/556 control subjects) and 2) a prospective nested case-control study in the PLCO Cancer Screening Trial (160 ovarian cancers/159 control subjects). Read More

    Molecular Diagnosis of Bacterial Vaginosis: an Update.
    J Clin Microbiol 2018 May 16. Epub 2018 May 16.
    Department of Gynecology/Obstetrics; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine.
    Bacterial vaginosis (BV) is the most common cause of vaginal discharge in reproductive age women. BV has been associated with poor reproductive outcomes like preterm delivery, acquisition of sexually transmitted infections including HIV, and pelvic inflammatory disease. BV represents acquisition of a diverse community of anaerobic and facultative bacteria and a reduction in lactobacilli. Read More

    Specific binding to differentially-expressed human CEACAMs determines the outcome of infections along the female reproductive tract.
    Infect Immun 2018 May 14. Epub 2018 May 14.
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    The gonococcal Opa proteins are an antigenically variable family of surface adhesins that bind human CEACAM1, CEACAM3, CEACAM5 and/or CEACAM6, cell surface glycoproteins that are differentially expressed on a broad spectrum of human cells and tissues. While presumed to be important for infection, the significance of various Opa-CEACAM mediated cellular interactions in the context of the genital tract has remained unclear. Here, we observe that CEACAM1 and CEACAM5 are differentially expressed on epithelia lining the upper and lower portions of the human female genital tract, respectively. Read More

    Patient Satisfaction and Treatment Adherence for Urban Adolescents and Young Adults with Pelvic Inflammatory Disease.
    Trauma Emerg Care 2018 Jan 25;3(1). Epub 2017 Aug 25.
    Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Objectives: Urban adolescents with pelvic inflammatory disease (PID) often seek care in emergency departments (ED). This study examines the effect of the ED patient experience - wait time (WT) and length of stay (LOS) - on satisfaction and medication adherence among urban adolescents with PID.

    Methods: Adolescents with PID were enrolled in an urban teaching hospital ED. Read More

    The elusive small bowel adenocarcinoma in the terminal ileum-A case report.
    Int J Surg Case Rep 2018 27;47:97-99. Epub 2018 Apr 27.
    Central Gippsland Health, 155 Guthridge Parade, Sale, Victoria 3850, Australia. Electronic address:
    Introduction: Small bowel malignancies are rare and often present with non-specific symptoms. Because of this, diagnosis of small bowel malignancies is often missed.

    Presentation Of Case: 71-year-old male presented with a four-week history of right iliac fossa pain and loss of weight. Read More

    Salivary alpha-amylase activity and cortisol in horses with acute abdominal disease: a pilot study.
    BMC Vet Res 2018 May 10;14(1):156. Epub 2018 May 10.
    Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Campus of Excellence Mare Nostrum, University of Murcia, 30100, Espinardo, Murcia, Spain.
    Background: The aim of this study was to evaluate salivary alpha-amylase (sAA), considered a non-invasive biomarker for sympathetic nervous system (SNS) activity, and salivary cortisol as possible pain-induced stress biomarker, in horses with acute abdominal disease. Therefore, a prospective observational study was performed in which both biomarkers were analyzed in a group of horses with acute abdomen syndrome, and compared with a group of healthy control horses by an unpaired Student's t-test. In addition, the possible relationship between both biomarkers, the score in Equine Acute Abdominal Pain scales version 1 (EAAPS-1 scale), Heart Rate (HR) and Respiratory Rate (RR), plasma lactate, the systemic inflammatory response syndrome (SIRS) score and serum amyloid A (SAA) concentration was assessed by a Spearman correlation test. Read More

    An integrative investigation of the therapeutic mechanism of Ainsliaea fragrans Champ. in cervicitis using liquid chromatography tandem mass spectrometry based on a rat plasma metabolomics strategy.
    J Pharm Biomed Anal 2018 Jul 27;156:221-231. Epub 2018 Apr 27.
    Jiangxi University of Traditional Chinese Medicine, No. 818 Yunwan Road, Nanchang 330002, PR China; State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, No. 56 Yangming Road, Nanchang 330006, PR China. Electronic address:
    Cervicitis is an extremely common gynecological disease and can be induced by diverse factors such as Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium infections. Long-term unhealed cervicitis may lead to a series of diseases including endometritis, salpingitis, pelvic inflammatory disease, and chorioamnionitis. However, the pathogenesis of cervicitis remains unknown. Read More

    The vaginal microbiota and its association with human papillomavirus, Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium infections: a systematic review and meta-analysis.
    Clin Microbiol Infect 2018 May 3. Epub 2018 May 3.
    Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (B2PHI), UVSQ, INSERM, Institut Pasteur, Université Paris-Saclay, Paris, France; AP-HP, Raymond-Poincaré Hospital, Garches, France.
    Background: The vaginal microbiota may modulate susceptibility to human papillomavirus (HPV), Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium infections. Persistent infection with a carcinogenic HPV is a prerequisite for cervical cancer, and C. trachomatis, N. Read More

    [Related immunologic mechanisms of chronic prostatitis: Advances in studies].
    Zhonghua Nan Ke Xue 2017 Jul;23(7):652-655
    Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
    Chronic prostatitis is a common male disease with a high incidence rate and a serious impact on the patients' quality of life. The pathogenesis of chronic prostatitis remains unclear though it is considered to be possibly related to infection, inflammation, and abnormal pelvic nerve muscle activity. Recently, a growing number of studies have reported immune imbalance and changes of inflammatory cytokines in patients with chronic prostatitis as well as a close correlation of abnormal immune response with the occurrence of diseases, pelvic pain symptoms, mental symptoms, hyperalgesia, and so on. Read More

    Rates of pelvic inflammatory disease and ectopic pregnancy in Australia, 2009-2014: ecological analysis of hospital data.
    Sex Transm Infect 2018 May 2. Epub 2018 May 2.
    Centre for Epidemiology and Biostatistics, Melbourne School of Population & Global Health, University of Melbourne, Parkville, Victoria, Australia.
    Objective: To analyse yearly rates of pelvic inflammatory disease (PID) and ectopic pregnancy (EP) diagnosed in hospital settings in Australia from 2009 to 2014.

    Methods: We calculated yearly PID and EP diagnosis rates in three states (Victoria, New South Wales, Queensland) for women aged 15-44 years using hospital admissions and emergency department (ED) attendance data, with population and live birth denominators. We stratified PID diagnoses as chlamydial-related or gonorrhoeal-related ( (CT)-related or (NG)-related), acute, unspecified and chronic, and analysed variations by year, age and residential area using Poisson regression models. Read More

    Postprandial increase in serum CA125 as a surrogate biomarker for early diagnosis of ovarian cancer.
    J Transl Med 2018 May 1;16(1):114. Epub 2018 May 1.
    Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200127, China.
    Background: CA125 is a prevalently used serum biomarker for detecting ovarian cancer over the last three decades. However, it has a significant deficiency in screening for early-stage cancer. With the purpose of exploring an effective approach to improve its performance in early diagnosis, we investigated the postprandial fluctuation pattern of cancer-derived CA125 and the underlying mechanism. Read More

    LC-Q-TOF-MS based plasma metabolomic profile of subclinical pelvic inflammatory disease: A pilot study.
    Clin Chim Acta 2018 Aug 27;483:164-169. Epub 2018 Apr 27.
    Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410008, PR China. Electronic address:
    Background: No index for non-invasive diagnosis of subclinical pelvic inflammatory disease (PID) is available at this time. Here we carried out a plasma metabolomic study to search for potential biomarkers to facilitate its non-invasive diagnosis.

    Method: The metabolites in plasma were detected by using an LC-Q-TOF-MS method. Read More

    Anti-fibrogenic Potential of Mesenchymal Stromal Cells in Treating Fibrosis in Crohn's Disease.
    Dig Dis Sci 2018 Apr 27. Epub 2018 Apr 27.
    Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, 26 Yuancun Er Heng Rd., Guangzhou, 510655, Guangdong, China.
    Background: Intestinal fibrosis is a major complication of CD and may result in stricture formation leading to intestinal obstruction. MSCs play multiple roles in active CD and fibrosis-associated diseases.

    Aims: This study was designed to investigate the role of MSCs in CD-associated intestinal fibrosis. Read More

    Encrusted cystitis caused by corynebacterium urealyticum: a case report with novel treatment strategy of intravesical dimethyl sulfoxide.
    Int Braz J Urol 2018 Apr 15;44. Epub 2018 Apr 15.
    Okan University, School of Medicine, Department of Urology, Istanbul, Tukey.
    Encrusted cystitis (EC) was first described as chronic cystitis with mucosal calcification in 1914 (1). It is a very rare chronic inflammatory disease presenting with dysuria, pelvic pain and gross hematuria. Voided urine contains mucus or calcified mucopurulent stone like particles. Read More

    Bacterial contamination hypothesis: a new concept in endometriosis.
    Reprod Med Biol 2018 Apr 18;17(2):125-133. Epub 2018 Jan 18.
    Graduate School of Medical Science Department of Obstetrics and Gynecology Kyoto Prefectural University of Medicine Kyoto Japan.
    Background: Endometriosis is a multifactorial disease that mainly affects women of reproductive age. The exact pathogenesis of this disease is still debatable. The role of bacterial endotoxin (lipopolysaccharide, LPS) and Toll-like receptor 4 (TLR4) in endometriosis were investigated and the possible source of endotoxin in the pelvic environment was examined. Read More

    Pyosalpinges after hysterosalpingography in a patient with lower genital tract infection and managed by laparoscopic surgery in a resource low tertiary hospital case report and literature review.
    Fertil Res Pract 2018 13;4. Epub 2018 Apr 13.
    Faculty of Medicine and Biomedical Sciences, University of Yaounde 1 and Department of Obstetrics and Gynecology, Douala General Hospital, Douala, Cameroon.
    Background: Pyosalpinges (a complication of pelvic inflammatory disease) is infection of the fallopian tubes and the morbidity associated with it has major health implications. We are reporting a case of pyosalpinges diagnosed after hysterosalpingography and managed by laparoscopic surgery at the Douala General Hospital, Cameroon.

    Case Presentation: A 29-year-old single woman, an assistant nurse of the Douala tribe in Cameroon. Read More

    Association between Prior Infection and Ectopic Pregnancy at a Tertiary Care Hospital in South Western Uganda.
    Obstet Gynecol Int 2018 1;2018:4827353. Epub 2018 Mar 1.
    Mbarara University of Science and Technology, Mbarara, Uganda.
    Background: Increase in the number of ectopic pregnancy is attributed to increase in the incidence of pelvic infections. is responsible for most of the sexually transmitted bacterial infections. If undetected and untreated, the infection can ascend to the upper genital tract and cause pelvic inflammatory disease (PID) and related sequelae (ectopic pregnancy and tubal factor infertility). Read More

    Anti-Inflammatory Effect of Feiyangchangweiyan Capsule on Rat Pelvic Inflammatory Disease through JNK/NF-B Pathway.
    Evid Based Complement Alternat Med 2018 28;2018:8476147. Epub 2018 Feb 28.
    Department of Natural Medicine, School of Pharmacy, The Fourth Military Medical University, Xi'an 710032, China.
    Objectives: In this study, we aimed to illustrate the preventive effect and possible mechanisms of Feiyangchangweiyan capsule (FYCWYC) on rat pelvic inflammatory disease (PID) model.

    Methods: To construct the rat PID model, upper genital tract was infected by multipathogen, and then drugs were orally administered for 8 days. The histological examination, immunohistochemical analysis, and ELISA were carried out. Read More

    Diagnostic Hysterolaparoscopy for Evaluation of Infertility: Our Experience in a Tertiary Care Hospital.
    J Hum Reprod Sci 2018 Jan-Mar;11(1):19-23
    Departments of Obstertics and Gynaecology, NEIGRIHMS, Shillong, Meghalaya, India.
    Objective: The objective of this study is to analyze the role of diagnostic hysterolaparoscopy (DHL) for evaluation of infertility in a tertiary care hospital.

    Materials And Methods: This retrospective study was conducted from July 2014 to June 2016.

    Results: Out of 151 patients, 58. Read More

    Biological feasibility and importance of a gonorrhea vaccine for global public health.
    Vaccine 2018 Apr 18. Epub 2018 Apr 18.
    Department of Microbiology and Immunology F. Edward Herbert School of Medicine, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20854, United States. Electronic address:
    There is a growing public health interest in controlling sexually transmitted infections (STIs) through vaccination due to increasing recognition of the global disease burden of STIs and the role of STIs in women's reproductive health, adverse pregnancy outcomes, and the health and well-being of neonates. Neisseria gonorrhoeae has historically challenged vaccine development through the expression of phase and antigenically variable surface molecules and its capacity to cause repeated infections without inducing protective immunity. An estimated 78 million new N. Read More

    Prediction of recurrent ectopic pregnancy: A five-year follow-up cohort study.
    Eur J Obstet Gynecol Reprod Biol 2018 Jun 10;225:70-78. Epub 2018 Apr 10.
    Obstetrics and Gynecology Department, Ain Shams University, Abbassia Square, Cairo, Egypt.
    Objective: To evaluate the value of different clinical risk factors in the prediction of recurrent ectopic pregnancies (REP).

    Study Design: This cohort study was carried out at a tertiary-care maternity hospital in Saudi Arabia, between January 2010 and June 2017. All women with a primary ectopic pregnancy (EP) were consecutively recruited, thoroughly assessed and followed up for a minimum duration of five-years (5. Read More

    [Osteoarticular tuberculosis nosology and diagnostic pitfalls].
    Rev Med Liege 2018 Apr;73(4):191-196
    Service de Médecine interne générale, CHR Citadelle, Liège, Belgique.
    Osteoarticular or skeletal tuberculosis is a clinical manifestation of extrapulmonary tuberculosis, occurring during the lympho-hematogenous spread of Mycobacterium tuberculosis from a pulmonary primary infection or reactivation of latent infection, years or even decades after the initial infection. Bone and joint tuberculosis is a rare disease with non-specific symptoms and radiological characteristics, often delaying diagnosis for more than a year after clinical onset. First-line hospital departments should develop a clinical suspicion when confronted with a subacute inflammatory bone or joint pathology in patients with underlying comorbidities, especially when coming from tuberculosis-endemic countries. Read More

    Quercetin protects against chronic prostatitis in rat model through NF-κB and MAPK signaling pathways.
    Prostate 2018 Apr 13. Epub 2018 Apr 13.
    Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, P.R. China.
    Background: Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a common disease of urology, of which the pathogenesis and therapy remain to be further elucidated. Quercetin has been reported to improve the symptoms of CP/CPPS patients. We aimed to verify the therapeutic effect of quercetin on CP/CPPS and identify the mechanism responsible for it. Read More

    [Radiation therapy in patients with inflammatory bowel disease. A review].
    Bull Cancer 2018 May 10;105(5):517-522. Epub 2018 Apr 10.
    Université Paris Est Créteil (UPEC), AP-HP, hôpitaux universitaires Henri-Mondor, service d'oncologie-radiothérapie & centre sein Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France; Inserm unité 955 EQ 07, 94010 Créteil, France. Electronic address:
    Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, are multifactorial diseases characterized by a chronic intestinal inflammation. Abdominal and pelvic irradiation can result in acute or chronic digestive toxicity. A few old studies on small population samples have suggested an increase of gastro-intestinal toxicities in patients with IBD in case of irradiation. Read More

    The Usefulness of CD34, PCNA Immunoreactivity, and Histopathological Findings for Prediction of Pain Persistence After the Removal of Endometrioma.
    Reprod Sci 2018 Jan 1:1933719118768697. Epub 2018 Jan 1.
    1 Department of Obstetrics and Gynecology, School of Medicine, Balıkesir University, Balıkesir, Turkey.
    Endometriosis is an estrogen-dependent inflammatory disease that causes infertility and chronic pelvic pain. Ovarian endometrioma is the most common form of endometriosis, and conservative surgery is the main preferred therapeutic approach for endometrioma-associated symptoms. The aim of this study was to investigate the persistence of cyclic and noncyclic pelvic pain (NCPP) after endometrioma excision and their relationship to clinical and histopathological findings. Read More

    [NefroCAPS phytolysin in complex management of women with chronic recurrent cystitis].
    Urologiia 2018 Mar(1):30-34
    Department of Urology, First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russia.
    Relevance: Recurrent lower urinary tract infections (UTI) in women are one of the most challenging problems of modern urology, which is associated both with their high incidence and increasing resistance of uropathogens to antibacterial drugs. Due to this fact, the phytotherapy of infectious and inflammatory diseases of the urinary tract has received increased attention.

    Aim: To investigate the effectiveness of Phytolysin nefroCAPS in the complex management of women with chronic recurrent cystitis. Read More

    [Intrauterine device and pelvic inflammatory disease: Myth or reality?]
    Gynecol Obstet Fertil Senol 2018 Apr 4;46(4):414-418. Epub 2018 Apr 4.
    Maternité des hôpitaux universitaires de Genève (HUG), boulevard de la Cluse 30, 1205 Genève, Suisse. Electronic address:
    Introduction: Intrauterine device (IUD) is a reliable contraceptive method that is long term reversible, and well tolerated. Numerous studies prove its efficiency and report rare complications that are attributed to it. However, its use is limited due to fear that it can cause a pelvic inflammatory disease (PID). Read More

    C-choline pharmacokinetics in recurrent prostate cancer.
    J Nucl Med 2018 Apr 6. Epub 2018 Apr 6.
    Memorial Sloan Kettering Cancer Center, United States.
    The aim of this study was to investigate the value of pharmacokinetic modeling for quantifying C-choline uptake in patients with recurrent prostate cancer. 194 patients with clinical suspicion of recurrent prostate cancer underwent C-choline dynamic positron emission tomography over the pelvic region (0-8-min), followed by 6 min static acquisition at ~25 min post-injection. Regions of interest (ROIs) were drawn over sites of disease identified by a radiologist with experience in nuclear medicine. Read More

    Current understanding on pharmacokinetics, clinical efficacy and safety of progestins for treating pain associated to endometriosis.
    Expert Opin Drug Metab Toxicol 2018 Apr 10;14(4):399-415. Epub 2018 Apr 10.
    a Academic Unit of Obstetrics and Gynecology , Ospedale Policlinico San Martino , Genoa , Italy.
    Introduction: Endometriosis is a chronic estrogen and progestogen responsive inflammatory disease associated with pain symptoms and infertility. The medical therapy of endometriosis aims to induce decidualization within the hormonally dependent ectopic endometrium, and it is often administered to ameliorate women' pain symptoms or to prevent post-surgical disease recurrence. A variety of progestins have been used in monotherapy for the medical management of women with endometriosis. Read More

    'It Opened My Eyes'-examining the impact of a multifaceted chlamydia testing intervention on general practitioners using Normalization Process Theory.
    Fam Pract 2018 Mar 28. Epub 2018 Mar 28.
    General Practice and Primary Health Care Academic Centre, University of Melbourne, Melbourne, Australia.
    Background: Chlamydia is the most common notifiable sexually transmissible infection in Australia. Left untreated, it can develop into pelvic inflammatory disease and infertility. The majority of notifications come from general practice and it is ideally situated to test young Australians. Read More

    Nutritional strategies to prevent gastrointestinal toxicity during pelvic radiotherapy.
    Proc Nutr Soc 2018 Apr 2:1-12. Epub 2018 Apr 2.
    Royal Marsden Clinical Trials Unit,The Royal Marsden NHS Foundation Trust,Sutton, Surrey,UK.
    Radiotherapy-induced damage to non-cancerous gastrointestinal mucosa has effects on secretory and absorptive functions and can interfere with normal gastrointestinal physiology. Nutrient absorption and digestion may be compromised. Dietary manipulation is an attractive option with sound rationale for intervention. Read More

    Acupuncture for chronic pelvic inflammatory disease: A systematic review protocol.
    Medicine (Baltimore) 2018 Mar;97(13):e0225
    Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province.
    Background: Chronic pelvic inflammation disease (PID) is a difficult-to-treat gynecological disorder with complex etiologies. Acupuncture has been applied widely for treating chronic pelvic inflammation or chronic pelvic pain symptoms in China. The aim of this review is to undertake a systematic review to estimate the effectiveness and safety of acupuncture on chronic PID. Read More

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