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Gynecol Obstet Fertil Senol 2019 Mar 13. Epub 2019 Mar 13.

Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Régional et Universitaire de Caen, 14000 Caen, France; Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0), Normandie University, UNICAEN 14000 Caen, France. Electronic address:

Gynecol Obstet Fertil Senol 2019 Mar 13. Epub 2019 Mar 13.

Service de Gynécologie-Obstétrique, CHU de Poitiers, 1 rue de la Milétrie, 86000 Poitiers, France. Electronic address:

The objective of this literature review is to update the recommendations for clinical practice about the diagnosis of Pelvic Inflammatory Disease (PID), microbiologic diagnosis excluded. An adnexal pain or cervical motion tenderness are the signs that allow a positive diagnosis of PID (LE2). Associated signs (fever, leucorrhoea, metrorrhagia) reinforce clinical diagnosis (LE2). Read More

Gynecol Obstet Fertil Senol 2019 Mar 13. Epub 2019 Mar 13.

Pôle d'Obstétrique - Reproduction - Gynécologie, Centre Aliénor d'Aquitaine, Hôpital Pellegrin, Place Amélie Raba Léon, 33076 Bordeaux cedex, France; UMR 5234, Microbiologie Fondamentale & Pathogénicité, Université de Bordeaux, 33076 Bordeaux, France. Electronic address:

Enferm Infecc Microbiol Clin 2019 Mar 13. Epub 2019 Mar 13.

Unidad de ITS Vall d'Hebron-Drassanes, Servicio de Enfermedades Infecciosas, Hospital Vall d'Hebron, Barcelona, España.

Sexually transmitted infections caused by Chlamydia trachomatis, including lymphogranuloma venereum and Mycoplasma genitalium have increased in last decade. This epidemiological scenario presents new challenges in order to improve and strengthen our control and prevention strategies. The routine clinical diagnosis of urethritis and cervicitis must be combined with the active search for the causal agent in men with symptoms of dysuria or proctitis, and in women with pelvic inflammatory disease. Read More

Contraception 2019 Mar 11. Epub 2019 Mar 11.

Univ. Bordeaux, Inserm, Bordeaux Population Health Research Centre, team PHARMACOEPIDEMIOLOGY, UMR 1219, Bordeaux, France; CHU de Bordeaux, Pôle de Santé Publique, Service de Pharmacologie Médicale, Bordeaux, France.

Objective: To compare the risk of all-cause death, hospitalizations (any cause), ectopic pregnancy, pelvic inflammatory disease or infection, uterine perforation, device removal, neuro-psychiatric drugs initiation, or new psychiatric visit(s) between levonorgestrel (LNG) 52mg intrauterine system (IUS) and copper intrauterine device (IUD) users in France.

Study Design: We identified a historical cohort of women aged 20-55years with a first dispensing of either LNG 52mg IUS or copper-IUD between January 1, 2010 and December 31, 2014, in the French National Claims database, SNDS. We used propensity score matching to balance the two groups on baseline sociodemographic and clinical characteristics to minimize confounding. Read More

Ugeskr Laeger 2019 Mar;181(10)

Pelvic inflammatory disease (PID) is a frequent cause of acute abdomen among sexually active females, although rarely seen in girls prior to their sexual debut. In this case report, a 12-year-old girl was hospitalised due to abdominal pain. She was virgo and premenarcheal. Read More

Diagn Pathol 2019 Mar 13;14(1):22. Epub 2019 Mar 13.

Department of Radiology, Maisonneuve-Rosemont Hospital, 5415 Boulevard de L'Assomption, Montreal, QC, Canada.

Background: Malakoplakia is a chronic inflammatory disease characterized by tissue infiltrates of large granular macrophages containing distinctive intracytoplasmic inclusions termed Michaelis-Gutmann (MG) bodies. The genitourinary system is the most commonly involved site, followed by the gastrointestinal tract. Malakoplakia may occur as a complication of primary or secondary immunosuppression and, therefore, renal transplant recipients are at risk. Read More

Proc Natl Acad Sci U S A 2019 Mar 12. Epub 2019 Mar 12.

Joint Program in Immunology, Department of Internal Medicine, Affiliated Guangzhou Women and Children's Medical Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510623, China;

Disruption of mucosal immunity plays a critical role in the pathogenesis of inflammatory bowel disease, yet its mechanism remains not fully elucidated. Here, we found that activating transcription factor 3 (ATF3) protects against colitis by regulating follicular helper T (T) cells in the gut. The expression of ATF3 in CD4 T cells was negatively correlated with the severity of ulcerative colitis in clinical patients. Read More

Gynecol Obstet Fertil Senol 2019 Mar 8. Epub 2019 Mar 8.

Unité fonctionnelle d'infectiologie régionale, Centre Hospitalier d'Ajaccio, Hôpital Eugénie, boulevard Rossini, 20 000 Ajaccio, France; Coordinateur du groupe des recommandations de la Société de Pathologie Infectieuse de Langue Française (SPILF), 21 rue Beaurepaire, 75010 Paris, France. Electronic address:

Numerous prophylactic antibiotic regimens (PBR) have been evaluated particularly in surgical abortion, hysterosalpingography or caesarean section, but few randomized comparative trials are available. Recommendations for PBR should take into account, expected and demonstrated benefits that reduce the risk of surgical site infection, but also the impact on the microbiota, the risk of bacterial resistance selection, and the overall cost to the community. In addition, antibiotic prophylaxis is not the only one factor to reduce the risk of surgical site infection, such as preventive measures and good hygiene practices. Read More

Microb Cell 2019 Jan 24;6(3):177-183. Epub 2019 Jan 24.

Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, North Carolina, USA.

Pelvic inflammatory disease (PID) is a female upper genital tract inflammatory disorder that arises after sexually transmitted bacterial infections (STI). Factors modulating risk for reproductive sequelae include co-infection, microbiota, host genetics and physiology. In a pilot study of cervical samples obtained from women at high risk for STIs, we examined the potential for unbiased characterization of host, pathogen and microbiome interactions using whole transcriptome sequencing analysis of ribosomal RNA-depleted total RNAs (Total RNA-Seq). Read More

Cell Transplant 2019 Mar 6:963689719833303. Epub 2019 Mar 6.

1 Department of Pathophysiology, Jagiellonian University Medical College, Krakow, Poland.

The autonomic innervation of the uterus is involved in multiple pathophysiological processes in both humans and animals. Pathological conditions such as adenomyosis or inflammatory pelvic disease are usually accompanied by significant alterations in uterine innervation. In the current study, we focused on autonomic innervation of uterine fibroids, the identification of recently described interstitial cells, telocytes, and the possible interplay between these structures. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Feb;44(2):173-179

Department of Radiology, Jiangsu Cancer Hospital, Nanjing 210029, China.

Objective: To explore the value of magnetic resonance diffusion-weighted imaging (MR-DWI) for evaluating inflammatory activity of perianal Crohn's fistula.
 Methods: A total of 55 patients, who were diagnosed as perianal Crohn's fistula by surgery and/or endoscopy, were assessed retrospectively. All patients, underwent pelvic magnetic resonance imaging (MRI) before and 32 weeks after the treatment, were divided into 2 groups according to their response to treatment: an effective group (34 cases) and an ineffective group (21 cases). Read More

Best Pract Res Clin Obstet Gynaecol 2019 Feb 6. Epub 2019 Feb 6.

Consultant in Reproductive Medicine and Minimal Access Surgery, University College London Hospitals, UK. Electronic address:

Gynaecologists are frequently involved in the management of conditions that may result in reduced fertility or treatments they administer can lead to infertility. Sexually transmitted infections and pelvic inflammatory disease are the most common cause of tubal damage. Gynaecologists can play an important role in the identification and early treatment of these diseases. Read More

Best Pract Res Clin Obstet Gynaecol 2019 Jan 29. Epub 2019 Jan 29.

Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK; Department of Obstetrics and Gynaecology, Princess Anne Hospital, Level F, Coxford Road, Southampton, SO16 5YA, UK.

Tubal factors account for approximately 25% of cases of infertility, and the most severe manifestation of tubal disease is hydrosalpinx, accounting for 10-30% of tubal diseases. Hydrosalpinx is a distension or dilatation of the fallopian tube in the presence of a distal tubal occlusion, and the most common cause is pelvic inflammatory disease. Women with hydrosalpinges have lower implantation and pregnancy rates in assisted reproductive technology (ART), due to a combination of mechanical and chemical factors thought to disrupt the endometrial environment. Read More

Radiol Case Rep 2019 Apr 13;14(4):501-504. Epub 2019 Feb 13.

Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA.

Pelvic inflammatory disease commonly occurs in adults and is most frequently caused by sexually-transmitted organisms. When left untreated, it can progress to abscess formation and subsequent infertility due to tubal scarring. This condition rarely occurs in the pediatric population and even less frequently in the absence of sexual activity. Read More

World J Urol 2019 Feb 27. Epub 2019 Feb 27.

Department of Surgery, Division of Urology, Sao Paulo Federal University (UNIFESP), São Paulo, Brazil.

Purpose: Evaluate the main etiologies and clinical characteristics of male urethral stricture disease (USD) in Brazil.

Methods: This multicentric study was performed using retrospective data collected from six Brazilian referral centers of urethral reconstruction. The database comprised data from 899 patients with USD who had undergone surgical treatment from 2008 to 2018. Read More

PLoS Med 2019 Feb 26;16(2):e1002750. Epub 2019 Feb 26.

Division of Rheumatology, Department of Paediatrics, The Hospital for Sick Children (SickKids), Toronto, Ontario, Canada.

Background: Joint inflammation is the common feature underlying juvenile idiopathic arthritis (JIA). Clinicians recognize patterns of joint involvement currently not part of the International League of Associations for Rheumatology (ILAR) classification. Using unsupervised machine learning, we sought to uncover data-driven joint patterns that predict clinical phenotype and disease trajectories. Read More

Can J Infect Dis Med Microbiol 2019 22;2019:1672109. Epub 2019 Jan 22.

Department of Public Health and Infectious Diseases, 'Sapienza' University, Rome 00185, Italy.

In healthy women, the cervicovaginal microbiota is mostly populated by spp., the main host defense factor of the female genital tract. In addition to Lactobacilli, other microorganisms populate the cervicovaginal microbiota, like spp. Read More

SAGE Open Med Case Rep 2019 13;7:2050313X19828235. Epub 2019 Feb 13.

Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Uchinada, Japan.

Background: Tumor-associated tissue eosinophilia is defined as an inflammatory response with the marked infiltration of eosinophils within tumor tissues. Tumor-associated tissue eosinophilia has been reported in various organs; however, no studies have examined the detailed cytopathological findings of tumor-associated tissue eosinophilia.

Case Presentation: A 49-year-old woman presented with lower abdominal and back pain that had started 1 month earlier. Read More

J Gynecol Obstet Hum Reprod 2019 Feb 19. Epub 2019 Feb 19.

Department of Obstetrics and Gynecology, la Conception Hospital, AP-HM, 13005 Marseille, France. Electronic address:

Purpose: Performing an antibiotic prophylaxis (ATBP) with a surgical abortion (SA) is recommended in numerous countries, including France where the CNGOF has issued guidelines. There is little data regarding the actual application of these guidelines in clinical practice. The aim of this study was to evaluate the practice of ATBP with SA and to assess the degree of compliance with the national guidelines. Read More

Gastroenterol Rep (Oxf) 2019 Feb 13;7(1):67-73. Epub 2018 Dec 13.

Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Background: This study sought to evaluate the risk factors for the development of colitis-associated neoplasia (CAN) in Chinese patients with inflammatory bowel disease (IBD).

Methods: IBD patients who developed CAN between 1999 and 2016 were identified from eight medical centers. In addition to initial pathology evaluation, a CAN diagnosis was confirmed by two expert pathologists. Read More

J Surg Case Rep 2019 Feb 8;2019(2):rjy352. Epub 2019 Feb 8.

Department of General Surgery, Nepean Hospital, Kingswood, New South Wales 2747, Australia.

Pneumatosis Intestinalis and hepato-portal venous gas are rare but ominous radiological findings that are synonymous with mesenteric ischaemia and bowel infarction in the majority of cases. Very uncommonly benign pathology have been implicated, including respiratory and inflammatory bowel disease. We provide a case of a 69-year-old gentleman with extensive peripheral vascular disease, who presented with generalized abdominal pain and findings of both pneumatosis intestinalis and hepato-portal venous gas. Read More

Saudi J Med Med Sci 2018 Jan-Apr;6(1):40-42. Epub 2017 Dec 14.

Department of Surgery, King Fahd Hospital of the University, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

We report a rare case of a 32-year-old woman with adhesive small bowel obstruction due to pelvic inflammatory disease. She had no history of abdominal surgery, gynecological complaints or constitutional symptoms of chronic illness. The diagnosis was based on the laparoscopic findings of small bowel adhesions, free peritoneal fluid, "violin string" adhesions of Fitz-Hugh-Curtis syndrome and left hydrosalpinx. Read More

J Ultrasound 2019 Feb 19. Epub 2019 Feb 19.

Department of Imaging, Bambino Gesù Children's Hospital Research Institute, P.za S.Onofrio 4, Via Torre di Palidoro, Palidoro, Rome, Italy.

Ultrasonography is the first-line imaging modality in the evaluation of the female pelvis in childhood and adolescence, because it is easy to perform, non-invasive and it does not require sedation. The transabdominal approach is preferred in children and adolescents, after filling the bladder to move away the bowel loops from the pelvis. The probe frequency must be adapted to age, thickness of tissues and depth of the structures under examination. Read More

Clin Infect Dis 2019 Feb 18. Epub 2019 Feb 18.

University of New South Wales, Sydney, Australia.

Gonorrhoea and chlamydia are important causes of pelvic inflammatory disease. Chlamydia also causes long-term sequelae, but the role of gonorrhoea is unclear. We followed 300,000 reproductive-aged women for 10 years for ectopic pregnancy and tubal infertility; our findings suggest that both infections confer similar increases in risk of these outcomes. Read More

BMC Genomics 2019 Feb 18;20(1):143. Epub 2019 Feb 18.

Department of Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, 720 Westview Drive, S.W, Atlanta, GA, 30310, USA.

Background: Genital C. trachomatis infection may cause pelvic inflammatory disease (PID) that can lead to tubal factor infertility (TFI). Understanding the pathogenesis of chlamydial complications including the pathophysiological processes within the female host genital tract is important in preventing adverse pathology. Read More

Int J Reprod Biomed (Yazd) 2018 Nov;16(11):697-702

Dermatovenerology Department, Kazan State Medical University, Kazan, Russia.

Background: Sexually transmitted infections play a great role in formation of inflammatory diseases of female urogenital system. These diseases can cause a decrease in the level of female sex hormones, as well as the ratio of estrogens and androgens.

Objective: To determine changes in the state of sex hormones in women with inflammatory diseases of ovaries associated with opportunistic urogenital flora. Read More

Open Access Rheumatol 2019 25;11:19-31. Epub 2019 Jan 25.

Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India,

In this narrative review, we overview the recent literature on enthesitis-related arthritis (ERA). For the purpose of our review, we searched Scopus for recent articles on this subject from 2013 onward, including some classic older articles for perspective. ERA is a juvenile idiopathic arthritis (JIA) subtype more common in males, associated in a majority with human leucocyte antigen B27. Read More

Womens Midlife Health 2018 27;4. Epub 2018 Apr 27.

1Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Health Research Innovation Centre, GB42, 3280 Hospital Dr NW, Calgary, AB T2N 4Z6 Canada.

Background: Some women with genetic risk of breast and/or ovarian cancer (e.g., BRCA1/2) opt to undergo prophylactic salpingo-oophorectomy (PSO, or surgical removal of the ovaries & fallopian tubes) in order to reduce their risk of cancer. Read More

Front Microbiol 2019 31;10:73. Epub 2019 Jan 31.

Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States.

and release peptidoglycan (PG) fragments from the cell as the bacteria grow. For these PG fragments are known to cause damage to human Fallopian tube tissue in organ culture that mimics the damage seen in patients with pelvic inflammatory disease. also releases pro-inflammatory PG fragments, but in smaller amounts than those from . Read More

World J Urol 2019 Feb 13. Epub 2019 Feb 13.

Department of Material Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield, UK.

The surgical mesh material used in the surgical treatment of stress urinary incontinence (SUI) and pelvic organ prolapse (POP) in women is associated with significant complications in some women. This has recently become a public health issue with involvement of national parliaments and regulatory bodies. The occurrence of mesh complications is thought to be a result of multifactorial processes involving problems related to the material design, the surgical techniques used and disease, and patient-related factors. Read More

Biomed Chromatogr 2019 Feb 12:e4509. Epub 2019 Feb 12.

Department of Pharmacy, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, P.R. China.

Ermiao Pill (EMW), a traditional Chines medicine (TCM), composed of a two-herb pair, Phellodendri Cortex (PC) and Atractylodis Rhizome (AR), is used for the treatment of pelvic inflammatory disease and inflammatory-related diseases. However, the underlying mechanism is still unknown. Compatibility plays a crucial role in the complex drugs such as those used in traditional Chinese medicine. Read More

Eur J Case Rep Intern Med 2018 22;5(2):000743. Epub 2018 Feb 22.

Internal Medicine Department, Ospedale La Carità, Locarno, Switzerland.

A young woman presented with right upper quadrant abdominal pain exacerbated by movement and breathing. Extensive evaluation revealed no gallstones or any other specific cause. Urine polymerase chain reaction results for were positive, so the clinical diagnosis of Fitz-Hugh-Curtis syndrome was confirmed. Read More

Trop Doct 2019 Feb 12:49475519826195. Epub 2019 Feb 12.

6 Additional Professor, Department of Microbiology, BP Koirala Institute of Health Sciences, Dharan, Nepal.

Chlamydia trachomatis is an important agent of pelvic inflammatory disease (PID) globally. Laboratory diagnosis, which is vital for early and appropriate treatment, remains a challenge in resource-limited settings. Our study was undertaken to detect C. Read More

Anaerobe 2019 Feb 10;56:61-65. Epub 2019 Feb 10.

Magee-Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA, 15213, USA; University of Pittsburgh, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Hospital, 300 Halket Street, Pittsburgh, PA, 15213, USA. Electronic address:

The CDC recommended outpatient treatment of pelvic inflammatory disease (PID) is an intramuscular dose of ceftriaxone plus 14 days of doxycycline, with or without metronidazole. European guidelines (2017) include moxifloxacin plus ceftriaxone as a first line regimen, particularly for women with Mycoplasma genitalium-associated PID. However, the susceptibility of bacteria recovered from the endometrium of women with PID to moxifloxacin is unknown. Read More

Obstet Gynecol 2019 Mar;133(3):416-422

National Clinician Scholars Program, the Department of Family Medicine, and the Institute for Healthcare Policy and Innovation, University of Michigan, Veterans Health Administration, Ann Arbor Healthcare System, the Department of Obstetrics and Gynecology, University of Michigan Medical School, and the Department of Health Behavior and Health Education, University of Michigan School of Public Health, Ann Arbor, Michigan; and the Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, Maryland.

Sexually transmitted infections (STI), including Chlamydia trachomatis and Neisseria gonorrhoeae, have reached record high rates in the United States. Sexually transmitted infections disproportionately affect reproductive-aged females aged 15-44 years, who account for 65% and 42% of the total reported C trachomatis and N gonorrhoeae cases, respectively. Undiagnosed STIs can result in serious health complications that put women at an increased risk for pelvic inflammatory disease, ectopic pregnancy, and tubal factor infertility. Read More

Int J Rheum Dis 2019 Feb 10. Epub 2019 Feb 10.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.

Aim: This study investigated the use of fat fraction (FF) measurements in the sacroiliac (SI) joint to determine radiologic progression in patients with spondyloarthritis (SpA).

Method: A total of 138 patients who underwent pelvic magnetic resonance imaging (MRI) between September 2014 and March 2015 were retrospectively evaluated. The FF based upon fat deposition (%) using fat signaling on T1 and T2 weighted images in the sacroiliac joint was quantified using a 6-echo variant of the modified Dixon technique. Read More

SAGE Open Med Case Rep 2019 16;7:2050313X18823592. Epub 2019 Jan 16.

University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', Zagreb, Croatia.

Fitz-Hugh-Curtis syndrome, a rare complication of pelvic inflammatory disease, is an inflammation of the liver capsule (thus called perihepatitis) and the surrounding peritoneum. It occurs extremely rarely in men and is typically characterized by a sudden onset of severe pain in the right upper abdominal quadrant. Ultrasound examination of the liver does not reveal any morphologic changes, and liver function tests are usually normal. Read More

Zhongguo Zhong Yao Za Zhi 2018 Dec;43(24):4741-4745

Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

To evaluate the clinical application of clinical practice guideline on traditional Chinese medicine therapy alone or combined with antibiotics for pelvic inflammatory disease and provide reference for the revision of the Guideline. Questionnaire research was conducted from applicability and application evaluation. A total of 1 311 copies of valid questionnaires were obtained, including 717 questionnaires on applicability evaluation and 594 questionnaires on application evaluation. Read More

Surg Endosc 2019 Jan 23. Epub 2019 Jan 23.

Department of Surgery, Hospital Clinic, University of Barcelona, Villarroel, 170, 08036, Barcelona, Spain.

Background: The transanal approach to pelvic dissection has gained considerable traction and utilization continues to expand, fueled by the transanal total mesorectal excision (TaTME) for rectal cancer. The same principles and benefits of transanal pelvic dissection may apply to the transanal restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA)-the TaPouch procedure. Our goal was to review the literature to date on the development and current state of the TaPouch. Read More

J Gastrointest Surg 2019 Jan 22. Epub 2019 Jan 22.

Department of Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.

Background: Portomesenteric venous thrombosis (PMVT) can occur after colorectal surgery. Most previous studies included patients with various diseases, especially inflammatory bowel disease. The prevalence and clinical significance of PMVT developing after surgery for colorectal cancer (CRC) remain unclear. Read More

Br J Pain 2019 Feb 15;13(1):54-58. Epub 2018 May 15.

Department of Orthopaedics and Traumatology, University Hospital of Siena, Siena, Italy.

Context: Vulvodynia is defined as a chronic vulvar pain non-associated with infectious, inflammatory, neoplastic or hormonal disorders.

Objectives: To present a case demonstrating the difficulty in assessing concomitant disease in vulvodynia.

Methods: A 26-year-old woman, presented with persistent vulvodynia. Read More

J Cancer 2019 1;10(1):28-34. Epub 2019 Jan 1.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

The aim of the study was to determine the association between pelvic inflammatory disease (PID) and breast, colorectal, gynecologic and urinary tract cancer. The source of data was a longitudinal dataset compiled by the Longitudinal Health Insurance Database 2000 (LHID2000) which was collected by the National Health Insurance program. Cases of PID, at least two outpatient visits and one admission, were diagnosed from 2000 to 2013. Read More

Vet Microbiol 2019 Feb 28;229:130-137. Epub 2018 Dec 28.

Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820, Merelbeke, Belgium. Electronic address:

In the past, bovine herpesvirus 4 (BoHV-4) has been suggested to be associated with metritis and endometritis. However, not many field studies investigated the association between BoHV-4 and subclinical endometritis (SCE). In the present study, the association between the intrauterine presence of BoHV-4 and SCE diagnosed during artificial insemination (AI) was examined on two dairy farms in Belgium. Read More

Sex Transm Dis 2019 Feb;46(2):73-79

Centre for Epidemiology and Biostatistics, Melbourne School of Population & Global Health, University of Melbourne, Parkville, Victoria, 3010, Australia.

Background: There are limited published data describing clinical features and therapeutic response in women meeting the criteria for presumptive treatment of pelvic inflammatory disease associated with Mycoplasma genitalium (MG-PID). The MG-PID has been reported to respond poorly to standard PID treatment regimens and while moxifloxacin is recommended in several treatment guidelines, published data to support its use are scant.

Methods: We conducted a retrospective study of women at Melbourne Sexual Health Centre between 2006 and 2017, who met the Centers for Disease Control and Prevention criteria for presumptive treatment of PID, and had MG detected as the sole pathogen. Read More

Am J Obstet Gynecol 2019 Jan 6. Epub 2019 Jan 6.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT. Electronic address:

Endometriosis can have a profound impact on women's lives, including associated pain, infertility, decreased quality of life, and interference with daily life, relationships, and livelihood. The first step in alleviating these adverse sequelae is to diagnose the underlying condition. For many women, the journey to endometriosis diagnosis is long and fraught with barriers and misdiagnoses. Read More

PLoS One 2019 9;14(1):e0207422. Epub 2019 Jan 9.

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

Problem: Chlamydia trachomatis infections are often associated with acute syndromes including cervicitis, urethritis, and endometritis, which can lead to chronic sequelae such as pelvic inflammatory disease (PID), chronic pelvic pain, ectopic pregnancy, and tubal infertility. As epithelial cells are the primary cell type productively infected during genital tract Chlamydia infections, we investigated whether Chlamydia has any impact on the integrity of the host epithelial barrier as a possible mechanism to facilitate the dissemination of infection, and examined whether TLR3 function modulates its impact.

Method Of Study: We used wild-type and TLR3-deficient murine oviduct epithelial (OE) cells to ascertain whether C. Read More

Arch Endocrinol Metab 2018 ;62(6):636-640

Division of Endocrinology, University of Buenos Aires, Buenos Aires, Argentina.

Objective: The advent of multikinase inhibitor (MKI) therapy has led to a radical change in the treatment of patients with advanced thyroid carcinoma. The aim of this manuscript is to communicate rare adverse events that occurred in less than 5% of patients in clinical trials in a subset of patients treated in our hospital.

Subjects And Methods: Out of 760 patients with thyroid cancer followed up with in our Division of Endocrinology, 29 (3. Read More

Sex Transm Infect 2019 Jan 3. Epub 2019 Jan 3.

Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

Objectives: A better understanding of infection (chlamydia)-related sequelae can provide a framework for effective chlamydia control strategies. The objective of this study was to estimate risks and risk factors of pelvic inflammatory disease (PID), ectopic pregnancy and tubal factor infertility (TFI) with a follow-up time of up until 8 years in women previously tested for chlamydia in the Chlamydia Screening Implementation study (CSI) and participating in the Netherlands Chlamydia Cohort Study (NECCST).

Methods: Women who participated in the CSI 2008-2011 (n=13 498) were invited in 2015-2016 for NECCST. Read More

Reprod Biol Endocrinol 2019 Jan 3;17(1). Epub 2019 Jan 3.

Reproductive Medicine and Immunology, Department of Obstetrics and Gynecology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 830 West Court, Suite 400, Vernon Hills, IL, 60061, USA.

Background: Chronic endometritis (CE) is a condition which results in reduced receptivity of embryos by dysregulated lymphocyte subsets, abnormal expression of cytokines, chemokines and other regulatory molecules in the endometrium (EM). Macroautophagy (autophagy), the highly conserved cellular homeostasis pathway, plays an essential role in the development and function of T lymphocytes, and supports T cell lineage stability and survival fitness. The possible relationships between autophagy and local cytokine milieus in repeated implantation failure (RIF) with CE have not been elucidated yet. Read More