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    MicroRNA-143 Targets ATG2B to Inhibit Autophagy and Increase Inflammatory Responses in Crohn's Disease.
    Inflamm Bowel Dis 2018 Mar;24(4):781-791
    Department of Colorectal Surgery, Guangzhou, Guangdong, China.
    Background: Dysfunctional autophagy is recognized as a contributing factor in many chronic inflammatory diseases, including Crohn's disease (CD). Genetic analyses have found that microRNA (miRNA) levels are altered in the intestinal tissues of CD patients.

    Methods: The Sequencing Alternative Poly-Adenylation Sites (SAPAS) method was used to compare the 3' end of the total mRNA sequence of 3 surgical specimens of CD patients (including inflamed tissues and corresponding noninflamed tissues in each case). Read More

    [Short-term outcomes of laparoscopic-assisted procedures for chronic complications of diverticular disease].
    Khirurgiia (Mosk) 2018 (3):16-23
    Ryzhikh State Research Coloproctology Center of Healthcare Ministry of the Russian Federation, Moscow, Russia.
    Aim: To estimate efficacy of laparoscopic-assisted procedures for chronic complications of diverticular disease (DD).

    Material And Methods: It was made a prospective comparative study within 2007-2015. Inclusion criteria were verified chronic DD (>6 weeks after the first attack) and bowel resection followed by primary anastomosis. Read More

    Acute pelvic inflammatory disease as a rare cause of acute small bowel obstruction.
    Acta Chir Belg 2018 Mar 21:1-3. Epub 2018 Mar 21.
    a Department of Abdominal Surgery and Transplantation , CHU Liege (CHU-ULg) , Liege , Belgium.
    Introduction: Small bowel obstruction (SBO) is a common presentation to emergency abdominal surgery. The most frequent causes of SBO are congenital, postoperative adhesions, abdominal wall hernia, internal hernia and malignancy.

    Patients: A 27-year-old woman was hospitalized because of acute abdominal pain, blockage of gases and stools associated with vomiting. Read More

    Fitz-Hugh-Curtis syndrome associated with tuberculous salpingitis and peritonitis: a case presentation and review of literature.
    BMC Gastroenterol 2018 Mar 20;18(1):42. Epub 2018 Mar 20.
    Department of Hepatology and Gastroenterology, AZ Sint-Lucas, Groene Briel 1, 9000, Ghent, Belgium.
    Background: Fitz-Hugh-Curtis syndrome or acute perihepatitis is considered a rare complication of pelvic inflammatory disease, mostly associated with chlamydial or gonococcal salpingitis. Peritoneal tuberculosis is a rare site of extra-pulmonary infection caused by Mycobacterium tuberculosis. Infection usually occurs after reactivation of latent tuberculous foci in the peritoneum and more seldom after contiguous spread from tuberculous salpingitis. Read More

    A Case Study of Sexual Abuse of a Minor.
    Afr J Reprod Health 2016 Mar;20(1):109-113
    Department of Family Medicine, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
    Child Sexual Abuse (CSA) is a crime against children. It is largely underreported and commonly goes unpunished in our society as it is commonly perpetrated by close ones including family relations. Victims are left with the adverse sequelae associated with it sometimes for life. Read More

    Molecular pathogenesis of interstitial cystitis based on microRNA expression signature: miR-320 family-regulated molecular pathways and targets.
    J Hum Genet 2018 Mar 12. Epub 2018 Mar 12.
    Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba, Japan.
    Interstitial cystitis (IC), also known as bladder pain syndrome, is a chronic inflammatory disease that affects the bladder. The symptoms of IC vary, including feeling an urgent need for immediate urination and of needing to urinate often, as well as bladder or pelvic pain. Despite its high incidence, no molecular diagnostic methods are available for IC, and the molecular pathogenesis is unknown. Read More

    Discovery of Blood Transcriptional Endotypes in Women with Pelvic Inflammatory Disease.
    J Immunol 2018 Mar 12. Epub 2018 Mar 12.
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
    Sexually transmitted infections withand/orand rates of pelvic inflammatory disease (PID) in women continue to rise, with reinfection being common because of poor adaptive immunity. Diagnosis remains imprecise, and pathogenesis data are derived primarily from monoinfection of mice withorBy comparing blood mRNA responses of women with- and/or-induced PID and histologic endometritis with those from women withand/orinfection limited to their cervix and asymptomatic uninfected women determined via microarray, we discovered important pathogenic mechanisms in PID and response differences that provide a pathway to biomarker discovery. Women with- and/or-induced PID exhibit overexpression of myeloid cell genes and suppression of protein synthesis, mitochondrial oxidative phosphorylation, and T cell-specific genes. Read More

    Perianal minimally invasive surgery (PAMIS) for rectal stump resection after previous colectomy.
    Int J Colorectal Dis 2018 Mar 10. Epub 2018 Mar 10.
    Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
    Purpose: Resection of a long rectal stump after previous colectomy or Hartmann procedure often requires a combined transperitoneal and transperineal approach because of limited access through a perineal incision alone. Risks associated with this procedure include iatrogenic injury to bowels, nerves, ureters, vessels and sexual organs. This study reports on the feasibility and safety of perianal minimally invasive surgery (PAMIS) for the resection of long rectal stumps that would otherwise require a combined transperitoneal and perianal approach. Read More

    Serum procalcitonin levels together with clinical features and inflammatory markers in women with tubo-ovarian abscess for discriminating requirements for surgery for full recovery.
    J Obstet Gynaecol 2018 Mar 9:1-4. Epub 2018 Mar 9.
    a Department of Obstetrics and Gynecology , Umraniye Training and Research Hospital , Istanbul , Turkey.
    Tubo-ovarian abscess (TOA) coexists in 15% of cases with pelvic inflammatory disease. Medical treatment is the first line of approach in women with TOA, however, 25% of cases fail to respond to antibiotics, therefore, these cases need to undergo surgical intervention. We aimed to determine factors leading to failure of medical treatment in women diagnosed with TOA. Read More

    [Conventional analgesics and non-pharmacological multidisciplinary therapeutic treatment in endometriosis: CNGOF-HAS Endometriosis Guidelines].
    Gynecol Obstet Fertil Senol 2018 Mar 3. Epub 2018 Mar 3.
    Centre d'étude et traitement de la douleur, hôpital Claude-Huriez, CHRU de Lille, rue Michel-Polonowski, 59000 Lille, France. Electronic address:
    A major symptom of endometriosis is pelvic pain with a wide range of intensity, rhythm, type, and expression, without clearly established relationship between pain and the disease. Endometriosis-associated pain has physical, psychological/behavioral and social consequences with a significant impact on patient quality-of-life in relation with the biopsychosocial model of chronic pain. Pain assessment in all of its dimensions, as well as assessing the consequences of pain is therefore a crucial part of therapeutic management. Read More

    Peripouch Fat Area Measured on MRI Image and Its Association With Adverse Pouch Outcomes.
    Inflamm Bowel Dis 2018 Mar;24(4):806-817
    Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.
    Background: There are no published studies on the impact of peripouch fat on pouch outcomes in inflammatory bowel disease (IBD) patients.

    Methods: Patients with pelvic MRI-DIXON scans from our prospectively maintained Pouch Database between 2002 and 2016 were evaluated. Peripouch fat area was measured on MRI-DIXON-F images at the middle height level of the pouch (area M) and the highest level of the pouch (area H). Read More

    Evaluation of noncontrast MR enterography for pediatric inflammatory bowel disease assessment.
    J Magn Reson Imaging 2018 Mar 5. Epub 2018 Mar 5.
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
    Background: Gadolinium deposition in normal tissues is being increasingly recognized. Children with inflammatory bowel disease (IBD) undergo frequent imaging with contrast-enhanced MR enterography (MRE).

    Purpose: To determine the impact of intravenous (IV) gadolinium in assessment of pediatric IBD by MRE. Read More

    Single-cell RNAseq reveals seven classes of colonic sensory neuron.
    Gut 2018 Feb 26. Epub 2018 Feb 26.
    Department of Pharmacology, University of Cambridge, Cambridge, UK.
    Objective: Integration of nutritional, microbial and inflammatory events along the gut-brain axis can alter bowel physiology and organism behaviour. Colonic sensory neurons activate reflex pathways and give rise to conscious sensation, but the diversity and division of function within these neurons is poorly understood. The identification of signalling pathways contributing to visceral sensation is constrained by a paucity of molecular markers. Read More

    Aminomethyl spectinomycins as therapeutics for drug-resistant gonorrhea and chlamydial co-infections.
    Antimicrob Agents Chemother 2018 Feb 26. Epub 2018 Feb 26.
    Microbiotix, Inc., Worcester, MA, USA.
    Bacterial sexually transmitted infections are widespread and common, with(gonorrhea) and(chlamydia) being the two most frequent causes. If left untreated, both infections can cause pelvic inflammatory disease, infertility, ectopic pregnancy and other sequelae. The recommended treatment for gonorrhea is ceftriaxone plus azithromycin (to empirically treat chlamydial co-infections). Read More

    MRI for diagnosis of axial spondyloarthritis: major advance with critical limitations 'Not everything that glisters is gold (standard)'.
    RMD Open 2018 12;4(1):e000586. Epub 2018 Jan 12.
    King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark.
    Recognition of axial spondyloarthritis (SpA) remains challenging, as no unique reference standard is available to ascertain diagnosis. Imaging procedures have been used for long in the field, in particular pelvic radiography, to capture structural changes evocative of sacroiliitis, the key feature in SpA. The introduction of MRI of the sacroiliac joints (SIJs) has led to a major shift in recognition of the disorder. Read More

    Dysbiosis of gut microbiota in promoting the development of colorectal cancer.
    Gastroenterol Rep (Oxf) 2018 Feb 11;6(1):1-12. Epub 2017 Oct 11.
    Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510020, China.
    Gastrointestinal microbiome, containing at least 100 trillion bacteria, resides in the mucosal surface of human intestine. Recent studies show that perturbations in the microbiota may influence physiology and link to a number of diseases, including colon tumorigenesis. Colorectal cancer (CRC), the third most common cancer, is the disease resulting from multi-genes and multi-factors, but the mechanistic details between gut microenvironment and CRC remain poorly characterized. Read More

    Is intrauterine device a risk factor for failure of conservative management in patients with tubo-ovarian abscess? An observational retrospective study.
    Arch Gynecol Obstet 2018 Feb 24. Epub 2018 Feb 24.
    Department of Obstetrics and Gynecology, Faculty of Health Sciences, Barzilai Medical Center, Ben-Gurion University of Negev, HaHistadrut Street 2, Ashkelon, Israel.
    Purpose: Tubo-ovarian abscess (TOA) is a serious and potentially life-threatening complication of pelvic inflammatory disease (PID). TOA formation may be an uncommon, but serious complication associated with the use of an intrauterine device (IUD). While the majority of TOA respond to antibiotic therapy, in approximately 25% of cases surgery or drainage is indicated. Read More

    Gonococcal and Chlamydial Cases of Pelvic Inflammatory Disease at 2 Canadian Sexually Transmitted Infection Clinics, 2004 to 2014: A Retrospective Cross-sectional Review.
    Sex Transm Dis 2018 Apr;45(4):280-282
    One hundred thirteen patients with gonococcal and chlamydial pelvic inflammatory disease were reviewed at 2 Canadian sexually transmitted infection clinics. Most patients (81%) with pelvic inflammatory disease were diagnosed as having chlamydia alone. Three treatment failures were seen in patients treated with ofloxacin. Read More

    Urine: Waste product or biologically active tissue?
    • Authors:
    Neurourol Urodyn 2018 Feb 21. Epub 2018 Feb 21.
    Aims: Historically, urine has been viewed primarily as a waste product with little biological role in the overall health of an individual. Increasingly, data suggest that urine plays a role in human health beyond waste excretion. For example, urine might act as an irritant and contribute to symptoms through interaction with-and potential compromise of-the urothelium. Read More

    Screening for Mullerian anomalies in patients with unilateral renal agenesis: Leveraging early detection to prevent complications.
    J Pediatr Urol 2018 Feb 9. Epub 2018 Feb 9.
    Brown University, Division of Pediatric Urology, Hasbro Children's Hospital, The Warren Alpert Medical School, Providence, RI, USA.
    Background: Mullerian anomalies have a known association with renal agenesis yet, to date, there are no formal recommendations for screening women with certain renal anomalies for associated genital tract disorders.

    Objective: The objective of this study is to review current data regarding the association between renal and Mullerian anomalies, and propose screening recommendations.

    Study Design: A comprehensive review of the literature was performed to identify relevant articles using the keywords "unilateral renal agenesis," "renal anomalies," and "Mullerian anomalies. Read More

    Microbiota changes impact on sexually transmitted infections and the development of pelvic inflammatory disease.
    Microbes Infect 2018 Feb 13. Epub 2018 Feb 13.
    Department of Infectious Diseases and Microbiology, University of Luebeck, 23538 Luebeck, Germany. Electronic address:
    The integrity of the human urogenital microbiome is crucial for women's health and well-being. An imbalance of the urogenital microbiota increases the risk for sexually transmitted infections. In this review, we discuss the microbiota composition of the female urogenital tract and its role in protecting from sexually transmitted infections and the emergence of pelvic inflammatory disease. Read More

    [Coexistence of polymyalgia rheumatica with ankylosing spondylitis: A case report].
    Agri 2018 Jan;30(1):35-37
    Department of Physýcal Medicine and Rehabilitation, Gaziantep University Faculty of Medicine, Gaziantep, Turkey.
    Ankylosing spondylitis is a chronic inflammatory disease that affects the spine and peripheral joints. Polymyalgia rheumatica is an inflammatory disease characterized by aching and prolonged morning stiffness mainly in the shoulder and pelvic girdles. Many other diseases may mimic polymyalgia rheumatica, and thus differential diagnosis is predominantly required. Read More

    To 'douche' or not to 'douche': hygiene habits may have detrimental effects on vaginal microbiota.
    J Obstet Gynaecol 2018 Feb 13:1-4. Epub 2018 Feb 13.
    b Microbiology and Plant Biology Laboratory, Faculty of Nature and Life Sciences , University of Abdelhamid Ibn Badis , Mostaganem , Algeria.
    The importance of a healthy vaginal micro-flora is indisputable. Therefore, intravaginal practices, such as vaginal douching (VD), may inhibit or lower the colonisation of beneficial Lactobacilli strains. Although the results of disrupted vaginal microbiota have been widely reported in the literature, direct microbicidal effects of products used for VD have been rarely studied. Read More

    Highlighting the clinical need for diagnosing Mycoplasma genitalium infection.
    Int J STD AIDS 2018 Jan 1:956462417753527. Epub 2018 Jan 1.
    10 Guy's and St Thomas' NHS Foundation Trust, UK.
    Despite Mycoplasma genitalium (MG) being increasingly recognised as a genital pathogen in men and women, awareness and utility of commercially available MG-testing has been low. The opinion of UK sexual health clinicians and allied professionals was sought on how MG-testing should be used. Thirty-two consensus statements were developed by an expert group and circulated to clinicians and laboratory staff, who were asked to evaluate their level of agreement with each statement; 75% agreement was set as the threshold for defining consensus for each statement. Read More

    Endometriosis alters brain electro-physiology, gene expression and increased pain sensitization, anxiety, and depression in female mice.
    Biol Reprod 2018 Feb 7. Epub 2018 Feb 7.
    Department of Obstetrics and Gynecology, Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.
    Endometriosis is an estrogen-dependent inflammatory disorder among reproductive-aged women associated with pelvic pain, anxiety, and depression. Pain is characterized by central sensitization, however it is not clear if endometriosis leads to increased pain perception or if women with the disease are more sensitive to pain, increasing the detection of endometriosis. Endometriosis was induced in mice and changes in behavior including pain perception, brain electrophysiology, and gene expression were characterized. Read More

    A case report of Tubo-ovarian abscess caused by Burkholderia pseudomallei.
    BMC Infect Dis 2018 02 8;18(1):73. Epub 2018 Feb 8.
    Division of Infectious Disease, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand.
    Background: Melioidosis, the disease caused by Burkholderia pseudomallei is endemic in the Northeastern part of Thailand, South-East Asia, and Northern Australia. The pelvic involvement of disease is rare even in an endemic area. Therefore, we describe in this report the clinical presentation, management, and outcome of the patient with primary tubo-ovarian abscess due to melioidosis. Read More

    Racial/ethnic disparities in the lifetime risk of Chlamydia trachomatis diagnosis and adverse reproductive health outcomes among women in King County, Washington.
    Clin Infect Dis 2018 Feb 6. Epub 2018 Feb 6.
    Department of Epidemiology, University of Washington, Seattle, Washington, USA.
    Background: Chlamydia trachomatis is the most common reportable infection in the US and can cause pelvic inflammatory disease (PID) and tubal factor infertility (TFI).

    Methods: We created lifetables to estimate the "lifetime" risk of chlamydia diagnosis among women age 15-34 in King County, Washington, US, 1992-2014. We estimated the lifetime risk of chlamydia-associated PID and TFI, incorporating published estimates of the risk of sequelae by chlamydia testing history. Read More

    Intravaginal Administration of Interleukin 12 during Genital Gonococcal Infection in Mice Induces Immunity to Heterologous Strains of.
    mSphere 2018 Jan-Feb;3(1). Epub 2018 Jan 31.
    Department of Microbiology and Immunology, University at Buffalo, Buffalo, New York, USA.
    It has previously been shown that genital tract infection within mice does not induce a state of protective immunity against reinfection but instead suppresses the development of adaptive immune responses againstdependent on transforming growth factor beta (TGF-β) and interleukin 10 (IL-10). Intravaginal administration during gonococcal infection of IL-12 encapsulated in biodegradable microspheres (IL-12/ms) reverses the immunosuppression and promotes the production of gamma interferon (IFN-γ) and of specific antibodies in serum and genital secretions and accelerates clearance of the infection. In this study, microspheres were shown to remain largely within the genital tract lumen and to release IL-12 over the course of 4 days. Read More

    Erroneously Suspected Ovarian Cancer in a 38-Year-Old Woman with Pelvic Inflammatory Disease and Chlamydia.
    Case Rep Obstet Gynecol 2017 13;2017:2514613. Epub 2017 Dec 13.
    Division of Gynecology, University Hospital of Zurich, Zurich, Switzerland.
    Chlamydia trachomatis is the most common bacterial cause of sexually transmitted disease and can cause pelvic inflammatory disease (PID), leading to severe outcomes such as ectopic pregnancy, infertility, or pelvic pain. We report a case of a 38-year-old patient with abdominal pain and dyspareunia. Clinical examination revealed diffuse abdominal tenderness. Read More

    Sarcoidosis and spondyloarthritis: A coincidence or common etiopathogenesis?
    Caspian J Intern Med 2018 ;9(1):100-103
    Department of Rheumatology, Kassab Institute of Orthopedics, Manouba. Tunisia.
    Background: Sarcoidosis is a multisystem granulomatous disease. Co-existence with spondyloarthritis (SA) has been more described as an adverse effect of anti-TNF α therapy than an association. We report herein a case of a typical sarcoidosis confirmed by histological proofs and an advanced SA with a bamboo column. Read More

    [Effect of Acupuncture on Inflammatory Cytokines in Patients with Acute Pelvic Inflammatory Disease].
    Zhen Ci Yan Jiu 2018 Jan;43(1):57-61
    Department of Acupuncture and Moxibustion, Foshan Hospital of Tradtional Chinese Medicine, Foshan 528000, Guangdong Province, China.
    Objective: To observe the effect of acupuncture on inflammatory indices and symptoms in patients with acute pelvic inflammatory disease, and investigate its mechanism.

    Methods: Seventy-nine patients with acute pelvic inflammatory disease were randomly assigned to a control group (=37) given conventional treatment and an observation group (=42) given conventional treatment and acupuncture therapy. In the observation group, acupionts of Zhongji(CV 3), Guanyuan(CV 4), Zigong(EX-CA 1), Zusanli(ST 36), Sanyinjiao(SP 6), etc. Read More

    Penile Mondor's disease in a patient treated with radical chemoradiation for anal cancer.
    Oxf Med Case Reports 2017 Aug 2;2017(8):omx036. Epub 2017 Aug 2.
    Department of Radiation Oncology, Bank of Cyprus Oncology Center 2006, Strovolos 2012, Nicosia, Cyprus.
    Penile Mondor's disease is a rare condition characterized by sclerosing thrombophlebitis of the superficial dorsal penile vein. Usually its causes are benign, but it is also evident in cancer patients. We report the case of a 62-year-old man with a cT4 anal cancer (infiltration of corpora spongiosa and penile bulb), associated with extensive loco-regional lymphadenopathy, who developed painful lumps in the midline of the anterior penile surface while receiving radical chemoradiotherapy. Read More

    Management of iatrogenic urorectal fistulae in men with pelvic cancer.
    Can Urol Assoc J 2017 Sep;11(9):E372-E378
    Department of Urology, University of Lisbon, School of Medicine, Hospital Santa Maria (CHLN), Lisbon; Portugal.
    Introduction: Urorectal fistula (URF) is a devastating complication of pelvic cancer treatments and a surgical challenge for the reconstructive surgeon. We report a series of male patients with URF resulting from pelvic cancer treatments, specifically prostate (PCa), bladder (BCa), and rectal cancer (RCa), and explore the differences and impact on outcomes between purely surgical and non-surgical treatment modalities.

    Methods: Between October 2008 and June 2015, 15 male patients, aged 59-78 years (mean 67), with URF induced by pelvic cancer treatments were identified in our institutions. Read More

    Future of human Chlamydia vaccine: potential of self-adjuvanting biodegradable nanoparticles as safe vaccine delivery vehicles.
    Expert Rev Vaccines 2018 Mar 6;17(3):217-227. Epub 2018 Feb 6.
    a Department of Biological Sciences , Alabama State University , Montgomery , AL , USA.
    Introduction: There is a persisting global burden and considerable public health challenge by the plethora of ocular, genital and respiratory diseases caused by members of the Gram-negative bacteria of the genus Chlamydia. The major diseases are conjunctivitis and blinding trachoma, non-gonococcal urethritis, cervicitis, pelvic inflammatory disease, ectopic pregnancy, tubal factor infertility, and interstitial pneumonia. The failures in screening and other prevention programs led to the current medical opinion that an efficacious prophylactic vaccine is the best approach to protect humans from chlamydial infections. Read More

    [The role of stress-induced chronic subclinical inflammation in the pathogenesis of the chronic pelvic pain syndrome IIIB in men].
    Urologiia 2017 Dec(6):131-137
    Department of Urology with Nephrology, YSMU of the Ministry of Health of the Russian Federation, Yaroslavl, Russia.
    This literature review of recent clinical and experimental studies describes the role of oxidative stress in the multifactorial and interdisciplinary pathogenesis of non-inflammatory chronic pelvic pain syndrome IIIB (CPPS-IIIB) in men. The authors outline general biological nature of oxidative stress and its mechanisms. More detailed information is presented on cytokine-mediated chronic subclinical inflammation, one of the key mechanisms of oxidative stress, which is currently being actively studied. Read More

    Identifying acute cervicitis in an era of less-frequent routine gynecologic examinations.
    JAAPA 2018 Feb;31(2):50-53
    Margaret Allen is a former PA program director for the University of Worcester in the United Kingdom, former clinical instructor in the Stanford University primary care associate program, and practiced family medicine at Ravenswood Family Health Center in East Palo Alto, Calif. The author has disclosed no potential conflicts of interest, financial or otherwise.
    Acute inflammation of the uterine cervix can lead to serious problems such as pelvic inflammatory disease (PID), endometritis, and complications of pregnancy and childbirth. As intervals for routine gynecologic screening examinations lengthen, cervical infections, especially if asymptomatic, may be missed. Annual wellness examinations and other patient visits outside routine gynecologic cancer screening visits should include brief evaluation with sexual risk assessment and a gynecologic examination if indicated. Read More

    Cervical Cancer Induction Enhancement Potential of Chlamydia Trachomatis: A Systematic Review.
    Curr Microbiol 2018 Jan 22. Epub 2018 Jan 22.
    Laboratory of Microbiology and Molecular Biology, Faculty of Medicine and Pharmacy of Fez (FMPF), Sidi Mohammed Ben Abdellah University (USMBA), Fez, Morocco.
    Human papillomavirus (HPV) persistent infection is the necessary but not sufficient cause of cervical cancer. Other co-factors are required to induce cell transformation that will evolve to malignant cervical cancer. These co-factors include physical elements, other sexually transmitted infections, and immune response. Read More

    Use of Pristinamycin for Macrolide-Resistant Mycoplasma genitalium Infection.
    Emerg Infect Dis 2018 Feb;24(2):328-335
    High levels of macrolide resistance and increasing fluoroquinolone resistance are found in Mycoplasma genitalium in many countries. We evaluated pristinamycin for macrolide-resistant M. genitalium in a sexual health center in Australia. Read More

    Restorative proctocolectomy and IPAA for right sided colonic adenocarcinoma on FAP: abdominal laparoscopic approach combined with transanal total mesorectal excision - video vignette.
    Colorectal Dis 2018 Jan 18. Epub 2018 Jan 18.
    Colon and Rectal Surgery Unit, Department of Biomedical Science, Rozzano, Italy.
    Transanal total mesorectal excision (taTME) has been proposed to overcome the difficulties related to pelvic dissection for low rectal cancer by a "bottom-up" technique set-up. This procedure has recently seen a widespread usage in the management of rectal cancer. However, its indications have been broadened to benign colorectal pathologies such as inflammatory bowel disease. Read More

    A silent epidemic: the prevalence, incidence and persistence of Mycoplasma genitalium among young, asymptomatic high-risk women in the United States.
    Clin Infect Dis 2018 Jan 12. Epub 2018 Jan 12.
    Department of Medicine, Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill.
    Background: Mycoplasma genitalium (MG) is a sexually transmitted infection (STI) that can result in pelvic inflammatory disease and adverse pregnancy outcomes. We analyzed data collected from a prospective study of asymptomatic bacterial vaginosis (BV) to determine the natural history of MG.

    Methods: Women aged 15-25 years, with ≥2 STI risk factors and asymptomatic BV were recruited from 10 sites throughout the United States. Read More

    Core curriculum case illustration: tubo-ovarian abscess.
    Emerg Radiol 2018 Jan 17. Epub 2018 Jan 17.
    Department of Radiology, University of Washington Medical Center, 1959 Northeast Pacific Street, Seattle, WA, 98195, USA.
    This is the 47th installment of a series that will highlight one case per publication issue from the bank of cases available online as part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for Study online at: http://www. Read More

    Detection of Chlamydia trachomatis in Pap Smear Samples from South Khorasan Province of Iran.
    Int J Fertil Steril 2018 Apr 15;12(1):31-36. Epub 2017 Feb 15.
    Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran. Electronic address:
    Background: Chlamydia trachomatis (CT), the most common bacterial sexually transmitted infection (STI), leads to pelvic inflammatory disease, infertility and chronic pelvic pain in women as well as an increased risk of vertical transmission, conjunctivitis and pneumonitis in infants. It may also be a co-factor along with human papillomavirus (HPV) in cervical cancer progression. We aimed to determine the prevalence of CT genotypes in genital specimens of women from South Khorasan, Iran and to test the association between CT and cytology statistics. Read More

    Atypical Sites of Deeply Infiltrative Endometriosis: Clinical Characteristics and Imaging Findings.
    Radiographics 2018 Jan-Feb;38(1):309-328
    From the Department of Diagnostic Imaging, Chamié Imagem da Mulher, Rua Casa do Ator, 1117, cj 72, São Paulo, SP 04546-004, Brazil (L.P.C.); Department of Diagnostic Imaging, Fleury Medicina e Saúde, São Paulo, Brazil (L.P.C., D.A.T., A.C.M.N.); Department of Female Reconstructive Surgery, Clínica Doutor Duarte Miguel Ferreira Rodrigues Ribeiro, São Paulo, Brazil (D.M.F.R.R.); and Department of Gynecology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil (P.C.S.).
    Endometriosis is defined as the presence of endometrial tissue that is located outside the uterine cavity and associated with fibrosis and inflammatory reaction. It is a polymorphic and multifocal disease with no known cure or preventive mechanisms. Patients may be asymptomatic or may experience chronic pelvic pain, dysmenorrhea, dyspareunia, or infertility. Read More

    Structural and Immunological Characterization of Novel Recombinant MOMP-Based Chlamydial Antigens.
    Vaccines (Basel) 2017 Dec 25;6(1). Epub 2017 Dec 25.
    Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA.
    is the most common cause of bacterial sexually transmitted infections worldwide. While infections resolve with antibiotic treatment, this is often neglected in women due to frequent asymptomatic infections, leading to disease progression and severe sequelae (pelvic inflammatory disease, ectopic pregnancy, infertility). Development of a vaccine againstis crucial. Read More

    Pelvic inflammatory disease risk following negative results from chlamydia nucleic acid amplification tests (NAATs) versus non-NAATs in Denmark: A retrospective cohort.
    PLoS Med 2018 Jan 2;15(1):e1002483. Epub 2018 Jan 2.
    Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom.
    Background: Nucleic Acid Amplification Tests (NAATs) are the recommended test type for diagnosing Chlamydia trachomatis (chlamydia). However, less sensitive diagnostic methods-including direct immunofluorescence (IF) and enzyme-linked immunoassay (ELISA)-remain in use in lower resourced settings. We estimate the risk of pelvic inflammatory disease (PID) following undiagnosed infection in women tested with non-NAATs and estimate the health gain from using accurate diagnostic tests. Read More

    Pelvic pyomyositis in children: changing trends in occurrence and management.
    Int Orthop 2017 Dec 30. Epub 2017 Dec 30.
    Department of Trauma and Orthopaedic Surgery, Alder Hey Children's Hospital, Liverpool, L12 2AP, UK.
    Aims: We present the largest series of paediatric pelvic pyomyositis from a temperate country, analyse the factors influencing long term prognosis and suggest a diagnostic protocol.

    Materials And Method: We included 41 patients diagnosed with primary paediatric pelvic pyomyositis between 1998 and 2016, in this study with a mean age of 7.5 years. Read More

    Risk of pelvic inflammatory disease after intrauterine insemination: a systematic review.
    Reprod Biomed Online 2018 Feb 24;36(2):164-171. Epub 2017 Nov 24.
    Human Reproduction Unit, Cruces University Hospital, Biocruces, University of the Basque Country; Biocruces Health Research Institute, University of the Basque Country, Bilbao, Spain. Electronic address:
    The aim of this study was to ascertain the incidence of pelvic inflammatory disease (PID) after intrauterine insemination (IUI). A systematic review was conducted using three different approaches: a search of IUI registries; a search of published meta-analyses; and a search of prospective randomized trials. Search terms were 'IUI', 'complications', 'infection' and 'PID'. Read More

    Toll-like receptor variants and cervical Atopobium vaginae infection in women with pelvic inflammatory disease.
    Am J Reprod Immunol 2018 Feb 29;79(2). Epub 2017 Dec 29.
    University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA.
    Problem: Toll-like (TLR) receptor genetic variants have been implicated in bacterial vaginosis (BV). We determined whether TLR variants are associated with fastidious BV-associated microbes that are linked with infertility following pelvic inflammatory disease (PID).

    Method Of Study: Sneathia spp. Read More

    Comparing the Frequency of Endometritis in Unexplained Infertility and Anovulatory Infertility.
    Adv Biomed Res 2017 30;6:151. Epub 2017 Nov 30.
    Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Acute pelvic inflammatory disease (PID) is a common reason for infertility. This study aimed to evaluate the frequency distribution of endometritis in women with unexplained infertility and comparison with frequency distribution of endometritis in anovulatory infertility to identify the importance of endometritis due to subacute PID evaluation in the case of infertility.

    Materials And Methods: This case-control study was done on 100 women with unexplained infertility and ovulatory infertility who referred to Shahid Beheshti clinic in 2013 in Isfahan, Iran. Read More

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