1,541 results match your criteria Pellagra


Isoniazid-induced pellagra in a patient with Crohn's disease.

Clin Case Rep 2020 May 19;8(5):815-818. Epub 2020 Feb 19.

Gastroenterology B Department La Rabta Hospital Tunis Tunisia.

Isoniazid preventive therapy in malnourished patients with Crohn's disease has a potential of inducing pellagra but still a very rare situation. No cases of isoniazid-induced pellagra in patients with Crohn's disease were reported in the literature. Pellagra can be easily treated if timely diagnosed. Read More

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http://dx.doi.org/10.1002/ccr3.2740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250970PMC

PELLAGRA.

Authors:

JAMA 2020 05;323(20):2100

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http://dx.doi.org/10.1001/jama.2019.13455DOI Listing

The 4 D's of Pellagra and Progress.

Int J Tryptophan Res 2020 16;13:1178646920910159. Epub 2020 Apr 16.

School of Biomedical Sciences, Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.

Nicotinamide homeostasis is a candidate common denominator to explain smooth transitions, whether demographic, epidemiological or economic. This 'NAD world', dependent on hydrogen-based energy, is not widely recognised as it is neither measured nor viewed from a sufficiently multi-genomic or historical perspective. Reviewing the importance of meat and nicotinamide balances during our co-evolution, recent history suggests that populations only modernise and age well with low fertility on a suitably balanced diet. Read More

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http://dx.doi.org/10.1177/1178646920910159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163231PMC

Pellagra secondary to selective eating in a child with autism.

Pediatr Dermatol 2020 Apr 23. Epub 2020 Apr 23.

Department of Dermatology, Penn State College of Medicine, Hershey, PA.

Once a significant cause of morbidity and mortality, health care providers rarely see primary pellagra in developed countries where fortification of foods with niacin is commonplace and niacin-rich foods are generally widely available. We report a ten-year-old boy with autism spectrum disorder who presented with photosensitive dermatitis which resolved after vitamin supplementation and dietary changes. In this child, the pellagra developed as the result of a long-term pattern of selective eating. Read More

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http://dx.doi.org/10.1111/pde.14176DOI Listing

Necrolytic Acral Erythema: Current Insights.

Clin Cosmet Investig Dermatol 2020 5;13:275-281. Epub 2020 Apr 5.

Department of Dermatology, Venereology and Leprosy, SN Medical College, Bagalkote 587102, Karnataka, India.

Necrolytic acral erythema (NAE) is now considered as a distinct clinical entity. It clinically presents as well demarcated hyperpigmented papules and plaques with thick adherent scales distributed symmetrically over dorsum of feet. It usually develops in patients with Hepatitis C virus (HCV) infection. Read More

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http://dx.doi.org/10.2147/CCID.S189175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147628PMC

Carcinoid Syndrome: A Review.

Cureus 2020 Mar 5;12(3):e7186. Epub 2020 Mar 5.

Medical Education, Brookwood Baptist Health, Birmingham, USA.

Carcinoid syndrome (CS) is a paraneoplastic syndrome caused by the release of serotonin and other substances from well-differentiated neuroendocrine tumors (NETs). The hallmark symptoms of carcinoid syndrome are flushing and diarrhea; atypical signs and symptoms can include wheezing, abdominal pain, valvular heart disease, telangiectasias, pellagra, and the complications of mesenteric fibrosis, including ureteral obstruction, bowel obstruction, and bowel ischemia. These symptoms are mediated by the release of serotonin (5-HT), histamine, kallikrein, prostaglandins, and tachykinins. Read More

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http://dx.doi.org/10.7759/cureus.7186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124884PMC

Pellagra in a Malawian woman.

Med Clin (Barc) 2020 Mar 13. Epub 2020 Mar 13.

Dermatology Department, Hospital Quirón Málaga, Málaga, Spain.

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http://dx.doi.org/10.1016/j.medcli.2019.12.021DOI Listing

Chapter 6: Vitamins and Oral Health.

Monogr Oral Sci 2020 7;28:59-67. Epub 2019 Nov 7.

Department of Cariology, Operative Dentistry and Dental Public Health, Indiana University School of Dentistry, Indianapolis, Indiana, USA.

Vitamins are essential organic compounds that catalyze metabolic reactions. They also function as electron donors, antioxidants or transcription effectors. They can be extracted from food and supplements, or in some cases, synthesized by our body or gut microbiome. Read More

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http://dx.doi.org/10.1159/000455372DOI Listing
January 2020

Gastrointestinal: Life-threatening diarrhea due to pellagra in an elderly patient.

J Gastroenterol Hepatol 2019 Dec 4. Epub 2019 Dec 4.

Clinical Gastroenterology, Faculty of Medicine, Universidade de Caxias do Sul, Caxias do Sul, Brazil.

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http://dx.doi.org/10.1111/jgh.14952DOI Listing
December 2019
3.504 Impact Factor

Role of Nicotinamide in Genomic Stability and Skin Cancer Chemoprevention.

Int J Mol Sci 2019 Nov 26;20(23). Epub 2019 Nov 26.

Laboratory of Molecular and Cell Biology, IDI-IRCCS, via dei Monti di Creta 104, 00167 Rome, Italy.

Nicotinamide (NAM) is an amide form of vitamin B3 and the precursor of nicotinamide adenine dinucleotide (NAD+), an essential co-enzyme of redox reactions for adenosine triphosphate (ATP) production and for other metabolic processes. As NAD+ status is critical in maintaining cellular energy, vitamin B3 deficiency mainly affects tissues that need high cellular energy causing pellagra and skin sun sensitivity. In animal models, NAD+ deficiency leads to UV sensitivity of the skin, impairs DNA damage response, and increases genomic instability and cancer incidence. Read More

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http://dx.doi.org/10.3390/ijms20235946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929077PMC
November 2019

[Cutaneous manifestations of nutritional deficiencies].

Rev Med Suisse 2019 Nov;15(672):2125-2130

Service de médecine interne, Département de médecine, CHUV, 1011 Lausanne.

In elderly or chronically ill patients, nutritional deficiencies are common and the presence of related skin lesions is not unusual. Recognition of such cutaneous involvement is important regarding the diagnosis essentially based on clinical elements. By using some clinical case reports, we will describe several pathologies related to nutritional deficiencies like scurvy, pellagra and acquired acrodermatitis enteropathica. Read More

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November 2019

Pellagra, a re-emerging disease: a case report of a girl from a community ravaged by insurgency.

Pan Afr Med J 2019 12;33:195. Epub 2019 Jul 12.

Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan.

Pellagra is a nutritional disorder of niacin deficiency which is characterized by triad of dermatitis, diarrhea and dementia. It is often seen in a state of poor nutrition among alcoholics, homeless and patients suffering from malabsorption. Though seldom occurs in children, its re-emerging is seen as a result of worsening food security in vulnerable population during conflict or insurgency. Read More

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http://dx.doi.org/10.11604/pamj.2019.33.195.17494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814328PMC
November 2019

Pellagrous dermatitis: a forgotten entity.

Postgrad Med J 2020 Apr 25;96(1134):234. Epub 2019 Oct 25.

Department of Dermatology, Government Medical College and Hospital, Chandigarh, Chandigarh, India

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http://dx.doi.org/10.1136/postgradmedj-2019-137177DOI Listing

Pellagra, an Almost-Forgotten Differential Diagnosis of Chronic Diarrhea: More Prevalent Than We Think.

Nutr Clin Pract 2019 Oct 9. Epub 2019 Oct 9.

Department of Hospitalist, Charlton Memorial Hospital, Fall River, MA, USA.

Pellagra, caused by vitamin B3 (niacin) deficiency, is traditionally described as dermatitis, diarrhea, dementia (3D), and even death (4D) syndrome if not recognized and treated promptly. Although full-blown pellagra with all 3D features has become rare, pellagra still exists, especially in high-risk populations, which is actually more prevalent than we think. We report that a recently treated patient with the full spectrum of 3D clinical features of pellagra presents as chronic diarrhea of unknown etiology for 1 year. Read More

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http://dx.doi.org/10.1002/ncp.10418DOI Listing
October 2019
1 Read

Public Health Aspects in the Prevention and Control of Vitamin Deficiencies.

Authors:
Ian Darnton-Hill

Curr Dev Nutr 2019 Sep 21;3(9):nzz075. Epub 2019 Jun 21.

The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, Charles Perkins Centre, Faculty of Medicine, University of Sydney, New South Wales 2006, Australia.

Vitamin deficiencies remain major etiological factors in the global burden of disease, especially in low- and middle-income countries. The purpose of this state-of-the-art review was to update current information on deficiencies of vitamins and public health approaches to addressing them. Some stages of life present a higher risk of deficiency than others: risks are higher in pregnant women, children (from conception to young childhood), adolescents, the elderly, and all of the over 800 million people globally who are undernourished. Read More

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http://dx.doi.org/10.1093/cdn/nzz075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775441PMC
September 2019
1 Read

Pellagra in the USA: unusual manifestations of a rare entity.

BMJ Case Rep 2019 Sep 30;12(9). Epub 2019 Sep 30.

Department of Medicine, Mount Auburn Hospital, Cambridge, Massachusetts, USA.

The case involves a 62-year-old female native of the USA with a history of bipolar disorder and chronic obstructive pulmonary disease who presented with intractable diarrhoea. Prior to the index admission, she was admitted to the intensive care unit and required pericardiocentesis for an idiopathic pericardial effusion with tamponade physiology. Following discharge, she suffered intractable diarrhoea and represented for medical evaluation. Read More

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http://dx.doi.org/10.1136/bcr-2019-230972DOI Listing
September 2019
2 Reads

Pellagra and anorexia nervosa: a case report.

Eat Weight Disord 2019 Sep 17. Epub 2019 Sep 17.

Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Via Bassi 21, 27100, Pavia, PV, Italy.

Background: While pellagra appears to be a rare entity currently, it may still develop. It is important to recognize how the disease manifests to ensure adequate and timely treatment.

Case Presentation: We present a case of pellagra secondary to anorexia nervosa in a 28-year-old woman. Read More

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http://dx.doi.org/10.1007/s40519-019-00781-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075726PMC
September 2019
2 Reads

Nicotinamide and NAFLD: Is There Nothing New Under the Sun?

Metabolites 2019 Sep 10;9(9). Epub 2019 Sep 10.

Hepatology, Department for BioMedical Research, University of Bern, 3008 Bern, Switzerland.

Nicotinamide adenine dinucleotide (NAD) has a critical role in cellular metabolism and energy homeostasis. Its importance has been established early with the discovery of NAD's therapeutic role for pellagra. This review addresses some of the recent findings on NAD physiopathology and their effects on nonalcoholic fatty liver disease (NAFLD) pathogenesis, which need to be considered in the search for a better therapeutic approach. Read More

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http://dx.doi.org/10.3390/metabo9090180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780119PMC
September 2019
1 Read

Cutaneous Metastasis of Internal Tumors.

Dermatol Clin 2019 Oct 10;37(4):545-554. Epub 2019 Jul 10.

Department of Dermatology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Ezralow Tower, Suite 5301, Los Angeles, CA 90033-9174, USA. Electronic address:

Cutaneous metastasis portends a poor prognosis. Therefore, a high clinical index of suspicion is necessary so that a clinician knows how to recognize the presentation of a cutaneous metastasis, while the pathologist must know the appropriate stains to order. In this review, the authors summarize the common and uncommon ways that these tumors will present. Read More

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http://dx.doi.org/10.1016/j.det.2019.05.012DOI Listing
October 2019
2 Reads

Image Gallery: Pellagra.

Authors:
C Xu W Zhang H Chen

Br J Dermatol 2019 12 20;181(6):e147. Epub 2019 Aug 20.

Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, 210000, China.

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http://dx.doi.org/10.1111/bjd.18366DOI Listing
December 2019
1 Read

Metabolic diseases in Andean paleopathology: Retrospect and prospect.

Authors:
Haagen D Klaus

Int J Paleopathol 2020 Jun 31;29:54-64. Epub 2019 Jul 31.

Department of Sociology and Anthropology, George Mason University, United States; Museo Nacional Sicán, Peru; Museo Nacional de Arqueología y Etnografía Hans Heinrich Brüning de Lambayeque, Peru. Electronic address:

John Verano's 1997 synthesis of Andean paleopathology guided two decades of research and was instrumental in establishing modern Andean paleopathology. This paper reviews the current state and new directions in the study of skeletal metabolic disorders in the Central Andean archaeological record. Key historical, ecological, methodological, and contextual issues intersect with the study of metabolic bone diseases in Andean paleopathology. Read More

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http://dx.doi.org/10.1016/j.ijpp.2019.06.008DOI Listing
June 2020
3 Reads

Elderly patient of Crohn's disease with dementia and edematous red plaques on dorsum of hands.

Eur J Intern Med 2019 Oct 24;68:e3-e4. Epub 2019 Jul 24.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2019.07.014DOI Listing
October 2019
4 Reads

Nicotinamide and Demographic and Disease transitions: Moderation is Best.

Int J Tryptophan Res 2019 3;12:1178646919855940. Epub 2019 Jul 3.

School of Biomedical Sciences, Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.

Good health and rapid progress depend on an optimal dose of nicotinamide. Too little meat triggers the neurodegenerative condition pellagra and tolerance of symbionts such as tuberculosis (TB), risking dysbioses and impaired resistance to acute infections. Nicotinamide deficiency is an overlooked diagnosis in poor cereal-dependant economies masquerading as 'environmental enteropathy' or physical and cognitive stunting. Read More

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http://dx.doi.org/10.1177/1178646919855940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610439PMC
July 2019
2 Reads

Verrucous dermatophytosis on photoexposed areas resembling pellagra in acquired immunodeficiency syndrome.

Indian J Dermatol Venereol Leprol 2019 Sep-Oct;85(5):499-502

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_3_19DOI Listing
February 2020
2 Reads
1.325 Impact Factor

Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study.

JAMA Psychiatry 2019 Jul 3. Epub 2019 Jul 3.

Queensland Brain Institute, University of Queensland, Brisbane, Australia.

Importance: Genome-wide association studies (GWASs) in European populations have identified more than 100 schizophrenia-associated loci. A schizophrenia GWAS in a unique Indian population offers novel findings.

Objective: To discover and functionally evaluate genetic loci for schizophrenia in a GWAS of a unique Indian population. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2019.1335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613304PMC
July 2019
17 Reads

Pellagra in isoniazid preventive and antiretroviral therapy.

IDCases 2019 3;17:e00550. Epub 2019 May 3.

School of Pharmaceutical Science and Technology (SPST), Health Science Platform, Tianjin University, Tianjin, 300072, China.

Pellagra is caused by cellular deficiency of niacin or its precursor amino acid, tryptophan. Isoniazid preventive therapy (IPT) is the administration of isoniazid (INH) to latent tuberculosis (TB) infection affected people preventing advancement to active TB disease. Although potentially life-saving for human immunodeficiency virus (HIV)-infected people with no active TB, IPT is arguably a possible player in pellagra in addition to well-known malnourishment determinants particularly in developing nations where diagnosis is often overlooked or delayed. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515148PMC
May 2019
11 Reads

Pellagra and pellagra-like erythema in a hospital setting in Lomé, Togo : retrospective study from 1997 to 2017.

Med Sante Trop 2019 Feb;29(1):68-70

Service dermatologie et IST, CHU Sylvanus Olympio, Université de Lomé, 14BP 200 Lomé, Togo.

Objective: The aim of this study was to describe the epidemiological, clinical, and therapeutic profile as well as the outcome and to document the causes of pellagra and pellagra-like erythema in a hospital setting in Lomé, Togo.

Methods: This retrospective study examined the records of patients seen for outpatient consultation and/or hospitalization in the three public dermatology departments of Lomé from January 1997 to September 2017.

Results: During the study period, 178 (0. Read More

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http://dx.doi.org/10.1684/mst.2018.0856DOI Listing
February 2019
5 Reads

The unwavering doctor who unraveled a medical mystery.

Int J Womens Dermatol 2019 Jun 17;5(2):137-139. Epub 2018 Oct 17.

Department of Dermatology, SUNY Downstate College of Medicine, Brooklyn, New York.

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https://linkinghub.elsevier.com/retrieve/pii/S23526475183004
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http://dx.doi.org/10.1016/j.ijwd.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451741PMC
June 2019
18 Reads

[Skin Manifestations of Pellagra].

Authors:
Yuuichi Yamamoto

Brain Nerve 2019 Apr;71(4):360-363

Department of Dermatology University of the Ryukyus, Graduate School of Medicine.

Pellagra is a type of dietary deficiency disease caused by an insufficiency of niacin or tryptophan. Symptoms of pellagra include diarrhea, dermatitis, and dementia. It is usually diagnosed based on a patient's dietary history and clinical symptoms. Read More

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http://dx.doi.org/10.11477/mf.1416201276DOI Listing
April 2019
11 Reads

Pellagra and Alcohol Dependence Syndrome: Findings From a Tertiary Care Addiction Treatment Centre in India.

Alcohol Alcohol 2019 Mar;54(2):148-151

Centre for Addiction Medicine, Department of Psychiatry National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bengaluru, India.

Aim: To define the prevalence and clinical presentation of pellagra, a multi-systemic disease caused by the deficiency of niacin, in patients admitted to a tertiary addiction treatment centre in southern India, with alcohol dependence syndrome (ADS)-(ICD10).

Methods: Review of the health records of 2947 patients who received inpatient care for ADS between 2015 and 2017.

Results: Out of 2947, 31 (1%) were diagnosed with pellagra. Read More

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http://dx.doi.org/10.1093/alcalc/agz004DOI Listing
March 2019
40 Reads
2.889 Impact Factor

Vitamin D: part II; cod liver oil, ultraviolet radiation, and eradication of rickets.

Int Orthop 2019 03 9;43(3):735-749. Epub 2019 Jan 9.

Hôpital Henri Mondor, 94010, Creteil, France.

Purpose: After Glisson's description of rickets, it took two centuries to realize that rickets was due to the absence of antirachitic nutrients in the diet or lack exposure of the skin to ultraviolet rays. This bone disease caused by vitamin D deficiency was one of the most common diseases of children 100 years ago. This paper explores how the definition, diagnosis, and treatment of rickets shifted in the first decades of the twentieth century. Read More

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http://dx.doi.org/10.1007/s00264-019-04288-zDOI Listing
March 2019
22 Reads

Recognising the return of nutritional deficiencies: a modern pellagra puzzle.

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Department of Nutrition, Alfred Health, Melbourne, Victoria, Australia.

A 34-year-old previously well woman presented with a 4-week history of diffuse erythema and crusting of skin affecting all four limbs. Examination revealed erythematous skin plaques associated with ulceration and fissuring affecting sun-exposed areas of all four limbs primarily on the dorsal surfaces, and a body mass index of 17 kg/m She was admitted under the infectious diseases unit, and an autoimmune and infective screen was performed which returned unremarkable. Dietetic consultation led to the diagnosis of severe protein-energy malnutrition, consequent to a severely restricted, primarily vegan, diet. Read More

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http://dx.doi.org/10.1136/bcr-2018-227454DOI Listing
November 2018
17 Reads

From the Editor Pellagra, Osler, Roberts, Goldberger, the Atherosclerotic Diet, Niacin, the Beginning of the Atherosclerotic Epidemic, and the First Lipid-Altering Drug.

Am J Cardiol 2019 02 22;123(4):697-700. Epub 2018 Nov 22.

Baylor Scott & White Heart and Vascular Institute, Baylor University Medical Center, Baylor Scott & White Health, Dallas, Texas. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029149183208
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http://dx.doi.org/10.1016/j.amjcard.2018.11.003DOI Listing
February 2019
4 Reads

Autophagy in malnutrition-associated dermatoses.

J Dermatol 2019 Jan 31;46(1):43-47. Epub 2018 Oct 31.

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Malnutrition-associated dermatoses including necrolytic migratory erythema (NME) and pellagra share common clinicopathological features; in particular, necrolytic changes in the upper epidermis. Here, we report the involvement of autophagy in the development of necrolysis in three patients with malnutrition-associated dermatoses. First, we examined an autophagy-specific molecule, microtubule-associated protein light chain 3 (LC3), using a monoclonal antibody. Read More

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http://dx.doi.org/10.1111/1346-8138.14694DOI Listing
January 2019
7 Reads

Pellagra Secondary to GI Malignancy and Fluorouracil-Based Chemotherapy.

J Oncol Pract 2018 Oct 10:JOP1800227. Epub 2018 Oct 10.

Beth Israel Deaconess Medical Center, Boston, MA.

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http://ascopubs.org/doi/10.1200/JOP.18.00227
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http://dx.doi.org/10.1200/JOP.18.00227DOI Listing
October 2018
13 Reads

Docetaxel induced pellagroid dematitis.

Indian J Dermatol Venereol Leprol 2018 Nov-Dec;84(6):723-725

Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_326_17DOI Listing
January 2019
8 Reads

Vitamin B3 in Health and Disease: Toward the Second Century of Discovery.

Methods Mol Biol 2018 ;1813:3-8

Niadyne Pharma, Inc., Fort Worth, TX, USA.

This introductory chapter briefly reviews the history, chemistry, and biochemistry of NAD (the term NAD as it is used here refers to both oxidized and reduced forms of the molecule) consuming ADP-ribose transfer enzymes as components of the involvement of vitamin B3 in health and disease. Read More

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http://dx.doi.org/10.1007/978-1-4939-8588-3_1DOI Listing
March 2019
4 Reads

Half and Half Nails in a Healthy Person.

Acta Dermatovenerol Croat 2017 Dec;25(4):303-304

Veronica Iliescu, MD, Zizinului street no. 40, Brasov, Romania;

Half and half nails or Lindsay's nails were first mentioned by Bean (1) in 1964 and later described by Lindsay (2) in 1967 in patients with chronic kidney disease. They can occur in various diseases but also in healthy individuals. A 57-year-old patient with no significant pathological personal history consulted us for discoloration of all his nails on the fingers (Figure 1) and toes (Figure 2). Read More

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December 2017
39 Reads

Azathioprine-induced pellagra in neuromyelitis optica: A case report and review of literature.

Mult Scler Relat Disord 2018 Oct 21;25:104-107. Epub 2018 Jul 21.

Department of Neurology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. Electronic address:

Neuromyelitis optica (NMO), also known as Devic's disease, is a classical autoimmune disorder of the central nervous system (CNS). The relapsing-remitting disease course contributes to application of a variety of immunosuppressants to prevent further relapses after high-dose methylprednisolone pulse therapy for acute attacks. Azathioprine is one of the most widely used immunosuppressive drugs during the remission stage of NMO due to its good efficacy and favorable side-effect profile. Read More

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http://dx.doi.org/10.1016/j.msard.2018.07.038DOI Listing
October 2018
5 Reads

What disease did goethe witness during his journey through the Italian Alps? Was it pellagra or another disease of malnutrition?

Nutr Diet 2018 11 24;75(5):541. Epub 2018 Jul 24.

Department of Molecular Medicine, Unit of History of Medicine, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1111/1747-0080.12458DOI Listing
November 2018
10 Reads

Malnutrition and skin disease in Far East prisoners-of-war in World War II.

Authors:
D Creamer

Clin Exp Dermatol 2018 Oct 31;43(7):766-769. Epub 2018 May 31.

Department of Dermatology, King's College Hospital, London, UK.

During the Second World War, thousands of captured British and Commonwealth troops were interned in prisoner-of-war (POW) camps in the Far East. Imprisonment was extremely harsh, and prisoners developed multiple pathologies induced by physical hardship, tropical infections and starvation. Immediately after the war, several POW doctors published their clinical experiences, including reports of skin disease caused by malnutrition. Read More

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http://dx.doi.org/10.1111/ced.13637DOI Listing
October 2018
14 Reads

Photosensitive disorders in HIV.

Authors:
Karen Koch

South Afr J HIV Med 2017 31;18(1):676. Epub 2017 Aug 31.

Wits University Donald Gordon Medical Centre, Johannesburg, South Africa.

Photosensitive disorders are common, affecting up to 5% of HIV-positive patients. HIV itself induces photosensitivity but photoaggravated drug reactions, porphyria cutanea tarda and nutritional disorders such as pellagra are also more common in patients with HIV. In South Africa, actinic lichenoid leukomelanoderma of HIV is a unique photosensitive disorder which is associated with advanced HIV. Read More

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http://dx.doi.org/10.4102/sajhivmed.v18i1.676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842981PMC
August 2017
10 Reads