305 results match your criteria Pediatrics Urinary Tract Infections and Pyelonephritis


Emphysematous Pyelonephritis Following Ureterovesical Reimplantation for Congenital Obstructive Megaureter. Pediatric Case Report and Review of the Literature.

Front Pediatr 2019 24;7. Epub 2019 Jan 24.

Pediatrics and Adolescentology Unit, Department of Internal Medicine, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Emphysematous pyelonephritis (EPN) is a rare, life-threatening necrotizing infection of the kidney. To date, very few cases of EPN have been described in the pediatric age. The first case of EPN in a toddler occurring after ureterovesical reimplantation for congenital obstructive megaureter is reported with a literature review. Read More

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https://www.frontiersin.org/article/10.3389/fped.2019.00002/
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http://dx.doi.org/10.3389/fped.2019.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354553PMC
January 2019
7 Reads

Vitamin A supplementation is effective for improving the clinical symptoms of urinary tract infections and reducing renal scarring in girls with acute pyelonephritis: a randomized, double-blind placebo-controlled, clinical trial study.

Complement Ther Med 2019 Feb 12;42:429-437. Epub 2018 Dec 12.

Neurology and Neuroscience Research Center, Qom University of Medical Sciences, Qom, Iran.

Introduction: It is believed that tubulointerstitial inflammation plays a role in the formation of renal scarring secondary to acute pyelonephritis (APN). Vitamin A is an anti-inflammatory agent that is involved in the re-epithelialization of damaged mucosal surfaces.

Objective: The aim of this study was to evaluate the efficacy of vitamin A supplementation in combination with antibiotics for improving urinary tract infections (UTIs) symptoms and preventing renal scarring in girls with APN. Read More

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http://dx.doi.org/10.1016/j.ctim.2018.12.007DOI Listing
February 2019
1 Read
2.216 Impact Factor

Ureaplasma urealyticum pyelonephritis presenting with progressive dysuria, renal failure, and neurologic symptoms in an immunocompromised patient.

Transpl Infect Dis 2018 Nov 25:e13032. Epub 2018 Nov 25.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri.

Ureaplasma urealyticum is a bacterial species correlated with urethritis in healthy individuals and invasive infections in immunocompromised patients. We describe a 20-year-old female with a history of remote heart transplant on everolimus, mycophenolate, and rituximab presenting with progressive urinary tract symptoms, renal failure, and neurologic symptoms. An extensive workup ultimately identified U urealyticum infection, and the patient successfully recovered after a course of azithromycin and doxycycline. Read More

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http://dx.doi.org/10.1111/tid.13032DOI Listing
November 2018
3 Reads

Urinary Tract Infections.

Pediatr Clin North Am 2019 02;66(1):1-13

Nephrology Section, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA; Department of Pediatrics, Ohio State University School of Medicine, 700 Children's Drive, Columbus, OH 43210, USA; Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, W308, Columbus, OH 43205, USA. Electronic address:

Urinary tract infection (UTI) is the second most common bacterial infection in children and is considered a public health threat given the mounting rates of antibiotic-resistance among uropathogens. This article highlights recent encouraging developments in UTI research. Further work is necessary to translate the discoveries into accessible, cost-effective technologies that will aid clinicians in real-time decision-making. Read More

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http://dx.doi.org/10.1016/j.pcl.2018.08.002DOI Listing
February 2019
1 Read

Fever duration during treated urinary tract infections and development of permanent renal lesions.

Arch Dis Child 2018 Nov 2. Epub 2018 Nov 2.

Department of Nephrology, "P&A Kyriakou" Children's Hospital, Athens, Greece.

Objective: To assess the effect of the duration of fever after the initiation of treatment (FAT) of febrile urinary tract infections (UTI) on the development of permanent renal lesions based on dimercaptosuccinic acid (DMSA) scintigraphy findings. To evaluate the FAT contribution to permanent renal lesion formation in relation to fever before treatment initiation (FBT), the presence of vesicourinary reflux (VUR), age and severity of infection.

Methods: The inpatient records of 148 children (median age: 2. Read More

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http://dx.doi.org/10.1136/archdischild-2017-314576DOI Listing
November 2018
2 Reads

Antinatriuretic phenomena seen in children with acute pyelonephritis may be related to the activation of intrarenal RAAS.

Medicine (Baltimore) 2018 Sep;97(36):e12152

Department of Pediatrics.

We investigated whether antinatriuretic phenomena [decreases in urinary sodium (uNa) and fractional excretion of sodium (FENa)] seen in children with acute pyelonephritis (APN) are associated with the renin-angiotensin-aldosterone system (RAAS).We examined 114 children experiencing their first episode of febrile urinary tract infection (fUTI) consecutively admitted to our hospital from July 2012 to June 2014. Blood tests [C-reactive protein, white blood cell count, erythrocyte sedimentation rate, and aldosterone (Aldo)] and urine tests [uNa, urine potassium (uK) and FENa] were performed upon admission. Read More

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http://dx.doi.org/10.1097/MD.0000000000012152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133464PMC
September 2018
17 Reads

Novel role for androgen signaling in pyelonephritis.

Kidney Int 2018 09;94(3):455-457

Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA; Division of Nephrology, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA. Electronic address:

Sex differences in urinary tract infection (UTI) susceptibility and severity are known, but have historically focused on anatomic differences between males and females. Until recently, experimental UTI has been limited to female animals due to ease of transurethral bladder catheterization. Olson and colleagues have developed a model of experimental UTI independent of sex that relies on direct bladder inoculation and thus permits investigation of sex differences in UTI susceptibility. Read More

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http://dx.doi.org/10.1016/j.kint.2018.05.020DOI Listing
September 2018
2 Reads

Androgen exposure potentiates formation of intratubular communities and renal abscesses by Escherichia coli.

Kidney Int 2018 09 3;94(3):502-513. Epub 2018 Jul 3.

Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address:

Females across their lifespan and certain male populations are susceptible to urinary tract infections (UTI). The influence of female vs. male sex on UTI is incompletely understood, in part because preclinical modeling has been performed almost exclusively in female mice. Read More

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http://dx.doi.org/10.1016/j.kint.2018.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109434PMC
September 2018
3 Reads

Bilateral multifocal acute lobar nephronia caused by .

BMJ Case Rep 2018 Apr 5;2018. Epub 2018 Apr 5.

Department of Paediatrics, Fuji City General Hospital, Shizuoka, Japan.

An 8-year-old boy presented to our hospital with complaints of fever, epigastric pain and headache. were isolated from urine and blood culture, bacteraemic urinary tract infection was clinically diagnosed. Although vancomycin and ampicillin were administrated, fever did not subside. Read More

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http://dx.doi.org/10.1136/bcr-2018-224336DOI Listing
April 2018
3 Reads

7-day compared with 10-day antibiotic treatment for febrile urinary tract infections in children: protocol of a randomised controlled trial.

BMJ Open 2018 03 2;8(3):e019479. Epub 2018 Mar 2.

Department of Paediatric Nephrology, The Medical University of Warsaw, Warsaw, Poland.

Introduction: The optimal duration of antibiotic therapy in children with febrile urinary tract infections (UTIs) is still a matter of debate. Current guidelines recommend treating children with febrile UTIs with antimicrobials for 7 to 14 days. We aim to compare the efficacy and safety of 7-day versus 10-day course of oral or sequence therapy (intravenous with a switch to oral) with cefuroxime/cefuroxime axetil for febrile UTIs in children. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-019479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855174PMC
March 2018
12 Reads

Interleukin-6/Stat3 signaling has an essential role in the host antimicrobial response to urinary tract infection.

Kidney Int 2018 06 21;93(6):1320-1329. Epub 2018 Feb 21.

Research Institute at Nationwide Children's Hospital, Center for Clinical and Translational Research, Columbus, Ohio, USA; Nephrology Section, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA. Electronic address:

The signaling networks regulating antimicrobial activity during urinary tract infection (UTI) are incompletely understood. Interleukin-6 (IL-6) levels increase with UTI severity, but the specific contributions of IL-6 to host immunity against bacterial uropathogens are unknown. To clarify this we tested whether IL-6 activates the Stat3 transcription factor, to drive a program of antimicrobial peptide gene expression in infected urothelium during UTI. Read More

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http://dx.doi.org/10.1016/j.kint.2017.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967986PMC
June 2018
17 Reads

Bilateral Obstructive Uropathy Caused by Congenital Bladder Diverticulum Presenting as Hypertensive Retinopathy.

J Korean Med Sci 2018 Feb 19;33(8):e54. Epub 2018 Feb 19.

Department of Pediatrics, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.

A congenital bladder diverticulum (CBD) is caused by inherent muscular weakness instead of obstruction of the bladder outlet. The major clinical conditions are recurrent urinary tract infection (UTI) and voiding dysfunction. This report describes a 15-year-old male adolescent who developed sudden visual disturbance resulting from hypertensive retinopathy. Read More

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http://dx.doi.org/10.3346/jkms.2018.33.e54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809749PMC
February 2018
9 Reads

Vitamin D deficiency is associated with urinary tract infection in children.

Arch Med Sci 2018 Jan 26;14(1):115-121. Epub 2016 Oct 26.

Department of Clinical and Chemical Pathology, Faculty of Medicine, Port Said University, Port Said, Egypt.

Introduction: In humans, vitamin D has been shown to play a role in infectious diseases, but its association with acquisition and a complicated course of febrile urinary tract infections (UTIs) has not been investigated. We aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D) levels and the risk of first time febrile UTI in children.

Material And Methods: This prospective case-control study included 50 children with first febrile UTI, with no risk factors for UTI, and 50 age- and sex-matched healthy siblings as controls. Read More

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http://dx.doi.org/10.5114/aoms.2016.63262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778422PMC
January 2018
3 Reads

The urinary and serum levels of IL-32 in children with febrile urinary tract infections.

Future Sci OA 2017 Nov 14;3(4):FSO242. Epub 2017 Sep 14.

Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Aim: We assessed the urinary and serum levels of IL-32 in pediatric patients with acute pyelonephritis (APN) with and without renal scarring.

Results: We enrolled children aged 2 months to 16 years with APN. Dimercaptosuccinic acid scans and ultrasonography studies were ordered for all patients, and a voiding. Read More

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http://www.future-science.com/doi/10.4155/fsoa-2017-0076
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http://dx.doi.org/10.4155/fsoa-2017-0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674269PMC
November 2017
8 Reads

Routine prophylaxis is not necessary to prevent renal scarring in children with urinary tract infection.

Evid Based Med 2017 12 22;22(6):208. Epub 2017 Oct 22.

Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA.

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http://dx.doi.org/10.1136/ebmed-2017-110784DOI Listing
December 2017
4 Reads

The clinical diagnosis and management of urinary tract infections in children and adolescents.

Paediatr Int Child Health 2017 Nov 5;37(4):273-279. Epub 2017 Oct 5.

c Department of Pediatrics, Division of Nephrology , Nationwide Children's Hospital , Columbus , OH , USA.

Urinary tract infections (UTI) are one of the most common and serious bacterial infections encountered by paediatricians and primary care physicians. Although the diagnosis and management of UTI appear simplistic, they remain among the most contentious issues in paediatrics. In part, UTI controversies stem from the absence of classic clinical symptoms, inappropriate urine specimen collection, modified urinary tract imaging recommendations, and diverse treatment and prevention strategies. Read More

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http://dx.doi.org/10.1080/20469047.2017.1382046DOI Listing
November 2017
1 Read

An update on new antibiotic prophylaxis and treatment for urinary tract infections in children.

Expert Opin Pharmacother 2017 Oct 27;18(15):1619-1625. Epub 2017 Sep 27.

a Pediatric Nephrology Unit , Trousseau Hospital and DHU i2B Inflammation-Immunopathology-Biotherapy , Paris , France.

Introduction: This review focuses on the treatment of urinary tract infections (UTI) in children and in particular its recent changes. Areas covered: Acute pyelonephritis, acute cystitis and asymptomatic bacteriuria or asymptomatic infections have to be clearly distinguished. Prompt treatment is required in pyelonephritis and cystitis, but not in asymptomatic bacteriuria or infection, in order to avoid selection of more virulent strains. Read More

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http://dx.doi.org/10.1080/14656566.2017.1383383DOI Listing
October 2017
4 Reads

Decreased Identification of Vesicoureteral Reflux: A Cautionary Tale.

Front Pediatr 2017 11;5:175. Epub 2017 Aug 11.

Innate Immunity Translational Research Center, Children Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN, United States.

Aim: To find the trend in patient's visits to our centers for vesicoureteral reflux (VUR). We hypothesize that VUR diagnosis and hence possible nephropathy recognition may be diminishing because of changing practice patterns.

Methods: Data were extracted from electronic medical records for new and follow-up patients aged 0-18 years with ICD-9/10 codes to correspond with VUR, VUR unilateral, VUR bilateral, and VUR with reflux nephropathy, as well as new patients with diagnoses of urinary tract infections (UTI) and pyelonephritis at two major pediatric centers from 2012 to 2015. Read More

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http://dx.doi.org/10.3389/fped.2017.00175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554494PMC
August 2017
9 Reads

Recent Studies on the Care of First Febrile Urinary Tract Infection in Infants and Children for the Pediatric Hospitalist.

Rev Recent Clin Trials 2017 ;12(4):269-276

Department of Pediatrics, University of North Carolina School of Medicine, 101 Manning Drive, CB # 7220, Chapel Hill, NC, 27514. United States.

Background: Urinary Tract Infection (UTI) is a common cause of bacterial infection in young children, and accounts for a significant number of pediatric hospitalizations.

Objective: To review recent publications focusing on the care of children hospitalized with their first febrile UTI.

Methods: A PubMed search was performed including publications from 2011-2016 on first febrile UTI in childhood. Read More

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http://dx.doi.org/10.2174/1574887112666170816143639DOI Listing
August 2018
9 Reads

Distal Ureteral Diameter Ratio is Predictive of Breakthrough Febrile Urinary Tract Infection.

J Urol 2017 Dec 8;198(6):1418-1423. Epub 2017 Jul 8.

Department of Urology, University of Iowa Hospitals and Clinics, Iowa City, Iowa; Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, Iowa. Electronic address:

Purpose: Distal ureteral diameter ratio is an objective measure that is prognostic of spontaneous resolution of vesicoureteral reflux. Along with likelihood of resolution, improved identification of children at risk for recurrent febrile urinary tract infections may impact management decisions. We evaluated the usefulness of ureteral diameter ratio as a predictive factor for breakthrough febrile urinary tract infections. Read More

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http://dx.doi.org/10.1016/j.juro.2017.06.095DOI Listing
December 2017
1 Read

Antibiotic Prophylaxis for Urinary Tract Infection-Related Renal Scarring: A Systematic Review.

Pediatrics 2017 May 6;139(5). Epub 2017 Apr 6.

Pediatric Nephrology, Dialysis and Transplant Unit, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, University of Milan, Italy

Context: Acute pyelonephritis may result in renal scarring. Recent prospective studies have shown a small benefit of antibiotic prophylaxis in preventing symptomatic and febrile urinary tract infections (UTIs), while being underpowered to detect any influence in prevention of renal damage.

Objectives: Review of the literature and a meta-analysis to evaluate the effect of antibiotic prophylaxis on UTI-related renal scarring. Read More

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http://dx.doi.org/10.1542/peds.2016-3145DOI Listing
May 2017
33 Reads

Short-course versus long-course oral antibiotic treatment for infections treated in outpatient settings: a review of systematic reviews.

Fam Pract 2017 09;34(5):511-519

Department of Family Medicine, University of Washington, Seattle, WA, USA.

Purpose: To summarize the evidence comparing the effectiveness of short and long courses of oral antibiotics for infections treated in outpatient settings.

Methods: We identified systematic reviews of randomized controlled trials for children and adults with bacterial infections treated in outpatient settings from Medline, Embase, CINAHL, Cochrane Database of Systematic Reviews and The Database of Review of Effects. Data were extracted on the primary outcome of clinical resolution and secondary outcomes. Read More

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http://academic.oup.com/fampra/article/34/5/511/3806591/Shor
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http://dx.doi.org/10.1093/fampra/cmx037DOI Listing
September 2017
37 Reads

ACR Appropriateness Criteria Urinary Tract Infection-Child.

J Am Coll Radiol 2017 May;14(5S):S362-S371

Specialty Chair, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Urinary tract infection (UTI) is common in young children and may cause pyelonephritis and renal scarring. Long-term complications from renal scarring are low. The role of imaging is to evaluate for underlying urologic abnormalities and guide treatment. Read More

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http://dx.doi.org/10.1016/j.jacr.2017.02.028DOI Listing
May 2017
36 Reads

Transient pseudohypoaldosteronism in infancy secondary to urinary tract infection.

J Paediatr Child Health 2017 May 24;53(5):458-463. Epub 2017 Feb 24.

Department of Endocrinology and Diabetes, The University of Western Australia, Perth, Western Australia, Australia.

Aim: Hyponatraemia with hyperkalaemia in infancy is a typical presentation of congenital adrenal hyperplasia. In the presence of pyelonephritis, the same biochemical picture can occur with transient type 1 pseudohypoaldosteronism (PHA-1) also termed type 4 renal tubular acidosis. Recognition of PHA-1 enables appropriate management thus avoiding unnecessary investigations and treatment. Read More

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http://dx.doi.org/10.1111/jpc.13481DOI Listing
May 2017
4 Reads

A Seven-Day Course of TMP-SMX May Be as Effective as a Seven-Day Course of Ciprofloxacin for the Treatment of Pyelonephritis.

Am J Med 2017 07 16;130(7):842-845. Epub 2017 Feb 16.

Division of Pediatric Infectious Diseases, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Md. Electronic address:

Background: The Infectious Diseases Society of America guidelines recommend either 14 days of trimethoprim-sulfamethoxazole (TMP-SMX) or 7 days of ciprofloxacin for the treatment of pyelonephritis. Antibiotic courses of 7 days of TMP-SMX vs 7 days of ciprofloxacin for pyelonephritis have not been previously compared. We evaluated the odds of a subsequent, symptomatic urinary tract infection (UTI) for women with Escherichia coli pyelonephritis receiving a 7-day course of TMP-SMX vs a 7-day course of ciprofloxacin. Read More

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http://dx.doi.org/10.1016/j.amjmed.2017.01.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632565PMC
July 2017
8 Reads

The value of delta neutrophil index in young infants with febrile urinary tract infection.

Sci Rep 2017 02 7;7:41265. Epub 2017 Feb 7.

Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.

Delta neutrophil index (DNI) is the fraction of circulating immature granulocytes, which reflects severe bacterial infections and septic condition but has not been studied in urinary tract infection (UTI). Here, we evaluated the value of DNI in predicting acute pyelonephritis (APN) or vesicoureteral reflux (VUR) using the data of 288 patients. Conventional inflammatory markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP]), and DNI were measured. Read More

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http://dx.doi.org/10.1038/srep41265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294644PMC
February 2017
18 Reads

Jan Winberg (1923-2003), a leader in urinary tract infection research.

Authors:
Kjell Tullus

Acta Paediatr 2017 Feb;106(2):196-198

Nephrology Unit, Great Ormond Street Hospital for Children, London, UK.

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http://dx.doi.org/10.1111/apa.13665DOI Listing
February 2017
2 Reads

Probiotics prophylaxis in pyelonephritis infants with normal urinary tracts.

World J Pediatr 2016 Nov 8;12(4):425-429. Epub 2016 Apr 8.

Kangnam Sacred Heart Hospital, Hallym University School of Medicine, Seoul, Korea.

Background: Pyelonephritis in infants is considered as a major factor for the formation of renal scar. To prevent recurrent pyelonephritis and renal damage, prophylaxis is extremely important. The aim of this study was to compare the effectiveness of probiotic and antibiotic prophylaxis or no-prophylaxis in infants with pyelonephritis and normal urinary tract. Read More

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http://dx.doi.org/10.1007/s12519-016-0013-2DOI Listing
November 2016
1 Read

Neutrophil gelatinase-associated lipocalin: utility in urologic conditions.

Pediatr Nephrol 2017 03 26;32(3):377-381. Epub 2016 Oct 26.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.

Neutrophil gelatinase-associated lipocalin (NGAL) is best known as a non-invasive early marker of acute kidney injury (AKI). However, recent published reports have described additional utility of both plasma NGAL (pNGAL) and urine NGAL (uNGAL) in various pathologic conditions within the pediatric urinary tract, including urinary tract infection, vesicoureteral reflux (VUR), renal scarring, and obstructive uropathy. These two forms of NGAL have different applications related to their mechanisms of upregulation: pNGAL can serve as a marker of systemic inflammatory conditions, whereas uNGAL is specific for insults to the renal epithelium. Read More

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http://dx.doi.org/10.1007/s00467-016-3540-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5274571PMC
March 2017
5 Reads

Inflammation drives renal scarring in experimental pyelonephritis.

Am J Physiol Renal Physiol 2017 01 19;312(1):F43-F53. Epub 2016 Oct 19.

Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio;

Acquired renal scarring occurs in a subset of patients following febrile urinary tract infections and is associated with hypertension, proteinuria, and chronic kidney disease. Limited knowledge of histopathology, immune cell recruitment, and gene expression changes during pyelonephritis restricts the development of therapies to limit renal scarring. Here, we address this knowledge gap using immunocompetent mice with vesicoureteral reflux. Read More

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http://dx.doi.org/10.1152/ajprenal.00471.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283888PMC
January 2017
16 Reads

Childhood urinary tract infection caused by extended-spectrum β-lactamase-producing bacteria: Risk factors and empiric therapy.

Pediatr Int 2017 Feb 19;59(2):176-180. Epub 2016 Oct 19.

Department of Biostatistics and Medical Informatics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.

Background: This study investigated risk factors of childhood urinary tract infection (UTI) associated with extended-spectrum β-lactamase (ESBL)-producing bacteria (ESBL-positive UTI) and evaluated antimicrobial resistance as well as empiric treatment of childhood UTI.

Methods: The records of children with positive urine culture between 1 January 2008 and 31 December 2012 were evaluated. Patients with positive urine culture for ESBL-producing bacteria were defined as the ESBL-positive group, whereas patients of the same gender and similar age with positive urine culture for non-ESBL-producing bacteria were defined as the ESBL-negative group. Read More

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http://dx.doi.org/10.1111/ped.13112DOI Listing
February 2017
6 Reads
3 Citations
0.731 Impact Factor

Delayed treatment of the first febrile urinary tract infection in early childhood increased the risk of renal scarring.

Acta Paediatr 2017 Jan 17;106(1):149-154. Epub 2016 Nov 17.

Department of Pediatric Nephrology, "P. and A. Kyriakou" Children's Hospital, Athens, Greece.

Aim: This study evaluated the controversial relationship between the duration of fever before treatment initiation (FBT) for a febrile urinary tract infection (UTI), with renal scarring based on dimercaptosuccinic acid scintigraphy (DMSA) findings.

Methods: The inpatient records of 148 children under two years of age with a first episode of febrile UTI were analysed. Acute and repeat DMSA findings, and clinical and laboratory parameters were evaluated. Read More

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http://dx.doi.org/10.1111/apa.13636DOI Listing
January 2017
18 Reads

Plasma neutrophil gelatinase-associated lipocalin: a marker of acute pyelonephritis in children.

Pediatr Nephrol 2017 03 15;32(3):477-484. Epub 2016 Oct 15.

Department of Pediatrics, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul, 08308, South Korea.

Objectives: This study was designed to compare the diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin (NGAL) with procalcitonin (PCT), C-reactive protein (CRP), and white blood cells (WBCs) for predicting acute pyelonephritis (APN) in children with febrile urinary tract infections (UTIs).

Materials And Methods: In total, 138 children with febrile UTIs (APN 59, lower UTI 79) were reviewed retrospectively. Levels of NGAL, PCT, CRP, and WBCs in blood were measured on admission. Read More

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http://dx.doi.org/10.1007/s00467-016-3518-yDOI Listing
March 2017
16 Reads

The role of voiding cystourethrography in the investigation of children with urinary tract infections.

Can Urol Assoc J 2016 May-Jun;10(5-6):210-214

The Hospital for Sick Children, Toronto, ON, Canada;; Division of Urology, Department of Surgery, University of Toronto, Toronto, ON, Canada.

Urinary tract infections (UTIs) represent a common bacterial cause of febrile illness in children. Of children presenting with a febrile UTI, 25-40% are found to have vesicoureteral reflux (VUR). Historically, the concern regarding VUR was that it could lead to recurrent pyelonephritis, renal scarring, hypertension, and chronic kidney disease. Read More

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http://dx.doi.org/10.5489/cuaj.3610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045350PMC
October 2016
17 Reads

Urinary Tract Infection: Pathogenesis and Outlook.

Trends Mol Med 2016 Nov 28;22(11):946-957. Epub 2016 Sep 28.

Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

The clinical syndromes comprising urinary tract infection (UTI) continue to exert significant impact on millions of patients worldwide, most of whom are otherwise healthy women. Antibiotic therapy for acute cystitis does not prevent recurrences, which plague up to one fourth of women after an initial UTI. Rising antimicrobial resistance among uropathogenic bacteria further complicates therapeutic decisions, necessitating new approaches based on fundamental biological investigation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14714914163011
Publisher Site
http://dx.doi.org/10.1016/j.molmed.2016.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159206PMC
November 2016
6 Reads

Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract.

Kidney Int 2016 09 9;90(3):568-79. Epub 2016 Jul 9.

Center for Clinical and Translational Research, Department of Pediatrics, The Research Institute at Nationwide Children's, Columbus, Ohio, USA; Division of Nephrology, Department of Pediatrics, Nationwide Children's, Columbus, Ohio, USA. Electronic address:

Diabetes mellitus is a systemic disease associated with a deficiency of insulin production or action. Diabetic patients have an increased susceptibility to infection with the urinary tract being the most common site. Recent studies suggest that Ribonuclease 7 (RNase 7) is a potent antimicrobial peptide that plays an important role in protecting the urinary tract from bacterial insult. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538163021
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http://dx.doi.org/10.1016/j.kint.2016.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576060PMC
September 2016
30 Reads

A study of asymptomatic bacteriuria in Egyptian school-going children.

Afr Health Sci 2016 Mar;16(1):69-74

Ain Shams university, Faculty of medicine, Pediatrics.

Background: Urinary tract infections (UTI) are a common and important clinical problem in childhood. Upper urinary tract infections (i.e. Read More

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http://dx.doi.org/10.4314/ahs.v16i1.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915397PMC
March 2016
4 Reads

Dimercaptosuccinic acid scan challenges in childhood urinary tract infection, vesicoureteral reflux and renal scarring investigation and management.

Minerva Urol Nefrol 2017 Apr 29;69(2):144-152. Epub 2016 Jun 29.

Department of Pediatrics, University of Patras Medical School, Patras, Greece.

Vesicoureteral reflux (VUR) is a precipitating factor in acute pyelonephritis (APN), and a risk factor for renal scar formation, even if VUR and APN occur independently. There is no scientific evidence on a specific diagnostic evaluation of children after a febrile urinary tract infection (UTI). Based on recent literature and our clinical experience, we reviewed the role of 99mTc dimercaptosuccinic acid (DMSA) renal scan in UTI/VUR imaging. Read More

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http://dx.doi.org/10.23736/S0393-2249.16.02509-1DOI Listing
April 2017
37 Reads

Usefulness of analytical parameters in the management of paediatric patients with suspicion of acute pyelonephritis. Is procalcitonin reliable?

Rev Esp Med Nucl Imagen Mol 2017 Jan - Feb;36(1):2-6. Epub 2016 Jun 18.

Servicio de Medicina Preventiva, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España.

Objective: To investigate the usefulness of procalcitonin (PCT) and other analytical parameters (white blood cell count [WBC], C-reactive protein [CRP]) as markers of acute renal damage in children after a first febrile or afebrile urinary tract infection (UTI).

Methods: A retrospective study was conducted on children with a first episode of UTI admitted between January 2009 to December 2011, and in whom serum PCT, CRP and white blood cell count were measured, as well as assessing the acute renal damage with renal scintigraphy with Tc-DMSA (DMSA) within the first 72h after referral. A descriptive study was performed and ROC curves were plotted, with optimal cut-off points calculated for each parameter. Read More

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http://dx.doi.org/10.1016/j.remn.2016.05.006DOI Listing
December 2017
11 Reads

Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection.

Korean J Pediatr 2016 Mar 31;59(3):139-44. Epub 2016 Mar 31.

Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.; Department of Pediatric Nephrology, Severance Children's Hospital, Seoul, Korea.

Purpose: Acute pyelonephritis (APN) is a serious bacterial infection that can cause renal scarring in children. Early identification of APN is critical to improve treatment outcomes. The neutrophil-lymphocyte ratio (NLR) is a prognostic marker of many diseases, but it has not yet been established in urinary tract infection (UTI). Read More

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http://dx.doi.org/10.3345/kjp.2016.59.3.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865625PMC
March 2016
37 Reads

Virulence Genes Profile of Multidrug Resistant Pseudomonas aeruginosa Isolated from Iranian Children with UTIs.

Acta Med Iran 2016 Mar;54(3):201-10

Young Researchers and Elite Club, Parand Branch, Islamic Azad University, Parand, Iran.

Virulent and resistant strains Pseudomonas aeruginosa (P. aeruginosa) is one of the most important cause of UTIs in pediatrics. The present study was carried to investigate the frequency of virulence factors in the multi-drug resistant strains of P. Read More

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March 2016
6 Reads

Computer model predicting breakthrough febrile urinary tract infection in children with primary vesicoureteral reflux.

J Pediatr Urol 2016 Oct 31;12(5):288.e1-288.e5. Epub 2016 Mar 31.

Department of Urology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address:

Introduction And Objective: Factors influencing the decision to surgically correct vesicoureteral reflux (VUR) include risk of breakthrough febrile urinary tract infection (fUTI) or renal scarring, and decreased likelihood of spontaneous resolution. Improved identification of children at risk for recurrent fUTI may impact management decisions, and allow for more individualized VUR management. We have developed and investigated the accuracy of a multivariable computational model to predict probability of breakthrough fUTI in children with primary VUR. Read More

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http://dx.doi.org/10.1016/j.jpurol.2016.03.005DOI Listing
October 2016
19 Reads

Predictive Accuracy of Urinary neutrophil gelatinase associated lipocalin (NGAL) for renal parenchymal involvement in Children with Acute Pyelonephritis.

Electron Physician 2016 Feb 25;8(2):1911-7. Epub 2016 Feb 25.

M.Sc., Rehabilitation Administration, MPH Student of Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: Urinary tract infections (UTIs) are among the most prevalent infections in children and infants. Early and accurate detection of renal parenchymal involvement in UTI is necessary for decision making and determining treatment strategies. The aim of this study was to determine the predictive accuracy of urinary neutrophil gelatinase-associated lipocalin (NGAL) for renal parenchymal involvement in children with acute pyelonephritis. Read More

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http://dx.doi.org/10.19082/1911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821304PMC
February 2016
12 Reads

The role of overweight and obesity in urinary tract infection in children.

Infez Med 2016 ;24(1):38-42

Department of Statistics, Qazvin University of Medical Sciences, Qazvin, Iran.

This study was conducted to determine the relationship between overweight/obesity and UTI in children. A comparison was made, in terms of overweight and obesity, between 135 children with UTI (case group) and 135 healthy children (control group). UTI was diagnosed through urine culture. Read More

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July 2017
3 Reads

Urine heat shock protein 70 levels as a marker of urinary tract infection in children.

Pediatr Nephrol 2016 09 24;31(9):1469-76. Epub 2016 Mar 24.

Department of Molecular Biology & Genetics, Faculty of Science, Istanbul University, Istanbul, Turkey.

Background: Heat shock proteins (HSPs) are a multi-family group of proteins which are upregulated by the cell in response to exposure to hazardous (stress) factors, including infectious agents, to prevent changes in protein structure. The aim of our study was to assess whether urine levels of the 70-kDa family of HSPs (HSP70s) increase in children with urinary tract infection (UTI) and to determine the optimal urine (u) HSP70 cut-off level to predict UTI in children.

Methods: Forty patients with symptomatic UTI (UTI group), 30 healthy children (control group), 21 asymptomatic patients with proven bacterial contamination in their urine culture (contamination group) and 30 patients with fever caused by other infections (non-UTI infection group) were enrolled in the study. Read More

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http://dx.doi.org/10.1007/s00467-016-3361-1DOI Listing
September 2016
45 Reads

Polymorphisms in α-Defensin-Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux.

J Am Soc Nephrol 2016 Oct 3;27(10):3175-3186. Epub 2016 Mar 3.

Innate Immunity Translational Research Center, Children's Foundation Research Institute at Le Bonheur Children's Hospital, Memphis, Tennessee; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee

The contribution of genetic variation to urinary tract infection (UTI) risk in children with vesicoureteral reflux is largely unknown. The innate immune system, which includes antimicrobial peptides, such as the α-defensins, encoded by DEFA1A3, is important in preventing UTIs but has not been investigated in the vesicoureteral reflux population. We used quantitative real-time PCR to determine DEFA1A3 DNA copy numbers in 298 individuals with confirmed UTIs and vesicoureteral reflux from the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) Study and 295 controls, and we correlated copy numbers with outcomes. Read More

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http://dx.doi.org/10.1681/ASN.2015060700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042661PMC
October 2016
31 Reads

Comparison of renal ultrasonography and dimercaptosuccinic acid renal scintigraphy in febrile urinary tract infection.

Infez Med 2015 Dec;23(4):323-9

Children Growth Research Center, Qazvin university of Medical Sciences, Qazvin, Iran.

Accurate and early diagnosis and appropriate treatment of patient with urinary tract infection (UTI) are essential for the prevention or restriction of permanent damage to the kidneys in children. The aim of this study was to compare renal ultrasonography (US) and dimercaptosuccinic acid (DMSA) renal scan in the diagnosis of patients with febrile urinary tract infection. This study involved the medical records of children with febrile urinary tract infection who were admitted to the children's hospital in Qazvin, Iran. Read More

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http://eprints.qums.ac.ir/3603/1/DrBarikani,Comparison%20of%
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December 2015
9 Reads

Mean platelet volume in young children with urinary tract infection.

Sci Rep 2015 Dec 15;5:18072. Epub 2015 Dec 15.

Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.

Mean platelet volume (MPV) has not yet been well-established in urinary tract infection (UTI). The purpose of this study was to evaluate the role of MPV as an acute phase reactant in children with UTI. Data from 118 young children (<2 years) with UTI between 2012 and 2013 were grouped as acute pyelonephritis (APN) and lower UTI according to the dimercaptosuccinic acid (DMSA) scan abnormalities. Read More

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http://dx.doi.org/10.1038/srep18072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678298PMC
December 2015
5 Reads

Expression and Significance of the HIP/PAP and RegIIIγ Antimicrobial Peptides during Mammalian Urinary Tract Infection.

PLoS One 2015 10;10(12):e0144024. Epub 2015 Dec 10.

Division of Nephrology, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, United States of America.

Recent evidence indicates that antimicrobial peptides (AMPs) serve key roles in defending the urinary tract against invading uropathogens. To date, the individual contribution of AMPs to urinary tract host defense is not well defined. In this study, we identified Regenerating islet-derived 3 gamma (RegIIIγ) as the most transcriptionally up-regulated AMP in murine bladder transcriptomes following uropathogenic Escherichia coli (UPEC) infection. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144024PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675559PMC
July 2016
25 Reads

[Nephronia in pediatrics: part of the spectrum of upper urinary tract infections. Clinical cases and review of the literature].

Rev Chilena Infectol 2015 Oct;32(5):564-8

Nephronia or focal acute nephritis corresponds to a localized inflammatory non-liquefactive kidney infection which may involve parenchyma of one or more renal lobes. It has been suggested that nephronia is part of the spectrum of upper urinary tract infections between acute pyelonephritis and renal abscess. It is associated with a prolonged clinical course, higher levels of inflammatory markers and an increased risk of renal scarring, compared to pyelonephritis. Read More

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http://dx.doi.org/10.4067/S0716-10182015000600011DOI Listing
October 2015
3 Reads