336 results match your criteria Pediatrics Urinary Tract Infections and Pyelonephritis


Swiss consensus recommendations on urinary tract infections in children.

Eur J Pediatr 2020 Jul 3. Epub 2020 Jul 3.

Paediatrics, Lucerne Children's Hospital, Cantonal Hospital Lucerne, Spitalstrasse, 6000, Luzern 16, Switzerland.

The kidneys and the urinary tract are a common source of infection in children of all ages, especially infants and young children. The main risk factors for sequelae after urinary tract infections (UTI) are congenital anomalies of the kidney and urinary tract (CAKUT) and bladder-bowel dysfunction. UTI should be considered in every child with fever without a source. Read More

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http://dx.doi.org/10.1007/s00431-020-03714-4DOI Listing

School Nurses on the Front Lines of Healthcare: Serious Infections in Students and Their Common Presenting Complaints.

NASN Sch Nurse 2020 Jun 19:1942602X20933680. Epub 2020 Jun 19.

Professor, Departments of Emergency Medicine and Pediatrics, Penn State College of Medicine, Attending Pediatric Emergency Medicine physician, Penn State Hershey Medical Center, Hershey, PA.

School nurses occasionally deal with students presenting with serious infections associated with common chief complaints. Although rare, the implications of missing the signs and symptoms of these infections are potentially life-threatening and devastating, with both immediate and long-term complications. Rapid recognition and stabilization, with immediate transfer to the closest emergency department via emergency medical services for antibiotic administration, is the key to reducing morbidity and mortality associated with these serious infections. Read More

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http://dx.doi.org/10.1177/1942602X20933680DOI Listing

Relationship between low serum vitamin D status and urinary tract infection in children: a case-control study.

Paediatr Int Child Health 2020 Jun 3:1-5. Epub 2020 Jun 3.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Urmia University of Medical Sciences , Urmia, Iran.

Background: A link between vitamin D deficiency and susceptibility to bacterial and viral infections has recently been suggested.

Aim: To investigate a possible association between vitamin D deficiency and urinary tract infection (UTI).

Methods: A case-control study was undertaken comprising 75 children aged 2-7 years with UTI (cases) compared with 75 healthy controls in terms of serum 25 hydroxyvitamin D [25(OH)D] levels. Read More

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http://dx.doi.org/10.1080/20469047.2020.1771244DOI Listing

Comparative Effectiveness of Antibiotic Treatment Duration in Children With Pyelonephritis.

JAMA Netw Open 2020 May 1;3(5):e203951. Epub 2020 May 1.

Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Importance: National guidelines recommend treating children with pyelonephritis for 7 to 14 days of antibiotic therapy, yet data are lacking to suggest a more precise treatment duration.

Objective: To compare the clinical outcomes of children receiving a short-course vs a prolonged-course of antibiotic treatment for pyelonephritis.

Design, Setting, And Participants: Retrospective observational study using inverse probability of treatment weighted propensity score analysis of data from 5 hospitals in Maryland between July 1, 2016, and October 1, 2018. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.3951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199115PMC

Accuracy of subjective vesicoureteral reflux timing assessment: supporting new voiding cystourethrogram guidelines.

Pediatr Radiol 2020 Jun 17;50(7):953-957. Epub 2020 Mar 17.

Division of Pediatric Urology, Department of Urology, Emory University School of Medicine, Children's Healthcare of Atlanta, 5730 Glenridge Dr., Suite 200, Atlanta, GA, 30328, USA.

Background: Bladder volume at the onset of vesicoureteral reflux (VUR) is an important prognostic indicator of spontaneous resolution and the risk of pyelonephritis.

Objective: We aim to determine whether pediatric urologists and pediatric radiologists can accurately estimate the timing of reflux by examining voiding cystourethrogram (VCUG) images without prior knowledge of the instilled contrast volume.

Materials And Methods: Total bladder volume and the volume at the time of reflux were collected from VCUG reports to determine the volume at the onset of VUR. Read More

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http://dx.doi.org/10.1007/s00247-020-04637-wDOI Listing

Associations of Plasma Neutrophil Gelatinase-associated Lipocalin, Anemia, and Renal Scarring in Children with Febrile Urinary Tract Infections.

J Korean Med Sci 2020 Mar 16;35(10):e65. Epub 2020 Mar 16.

Department of Pediatrics, Korea University Guro Hospital, Seoul, Korea.

Background: Neutrophil gelatinase-associated lipocalin (NGAL), a bacteriostatic agent, is known to inhibit erythropoiesis leading to anemia. We aimed to investigate the associations of NGAL, anemia, and renal scarring in children with febrile urinary tract infections (UTIs).

Methods: We retrospectively reviewed the medical records of 261 children with febrile UTIs. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073316PMC

Evolving surgical management of pediatric vesicoureteral reflux: is open ureteral reimplantation still the 'Gold Standard'?

Int Braz J Urol 2020 May-Jun;46(3):314-321

Department of Urology, Yale University School of Medicine, New Haven, CT 06520, USA.

Vesicoureteral reflux, the retrograde flow of urine from the bladder into the upper urinary tract, is one of the most common urologic diagnoses in the pediatric population. Once detected, therapeutic options for urinary reflux are diverse, ranging from observation with or without continuous low-dose prophylactic antibiotics to a variety of operative interventions. While a standardized algorithm is lacking, it is generally accepted that management be tailored to individual patients based on various factors including age, likelihood of spontaneous resolution, risk of subsequent urinary tract infections with renal parenchymal injury, and parental preference. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2020.99.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088498PMC
January 2020

Improving Antibiotic Prescribing for Pediatric Urinary Tract Infections in Outpatient Settings.

Pediatrics 2020 04 3;145(4). Epub 2020 Mar 3.

Institute for Health Research, Kaiser Permanente Colorado, Aurora, Colorado.

Objectives: To determine if a multicomponent intervention was associated with increased use of first-line antibiotics (cephalexin or sulfamethoxazole and trimethoprim) among children with uncomplicated urinary tract infections (UTIs) in outpatient settings.

Methods: The study was conducted at Kaiser Permanente Colorado, a large health care organization with ∼127 000 members <18 years of age. After conducting a gap analysis, an intervention was developed to target key drivers of antibiotic prescribing for pediatric UTIs. Read More

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http://dx.doi.org/10.1542/peds.2019-2503DOI Listing

Relationship between Breastfeeding, Birth History, and Acute Pyelonephritis in Infants.

J Korean Med Sci 2020 Mar 2;35(8):e32. Epub 2020 Mar 2.

Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Although the clinical importance of the immunological benefits of breastfeeding has been emphasized for decades, their direct relationship with acute pyelonephritis (APN) is still not clear. Our goal was to determine whether breastfeeding truly provides protection against APNs, while investigating the effects of other factors such as sex, age, mode of delivery, and birth weight on APN.

Methods: A total of 62 infants under 6 months of age who had both microbiologically and radiologically-confirmed APN were enrolled in the case group. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049624PMC

Prevalence of respiratory viruses and antiviral MxA responses in children with febrile urinary tract infection.

Eur J Clin Microbiol Infect Dis 2020 Jul 11;39(7):1239-1244. Epub 2020 Feb 11.

Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, 20521, Turku, Finland.

Blood myxovirus resistance protein A (MxA) has broad antiviral activity, and it is a potential biomarker for symptomatic virus infections. Limited data is available of MxA in coinciding viral and bacterial infections. We investigated blood MxA levels in children hospitalized with a febrile urinary tract infection (UTI) with or without simultaneous respiratory virus infection. Read More

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http://dx.doi.org/10.1007/s10096-020-03836-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088029PMC

Sex effects in pyelonephritis.

Pediatr Nephrol 2020 Feb 10. Epub 2020 Feb 10.

Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8208, St. Louis, MO, 63110, USA.

Urinary tract infections (UTIs) are generally considered a disease of women. However, UTIs affect females throughout the lifespan, and certain male populations (including infants and elderly men) are also susceptible. Epidemiologically, pyelonephritis is more common in women but carries increased morbidity when it does occur in men. Read More

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http://dx.doi.org/10.1007/s00467-020-04492-9DOI Listing
February 2020

Symptom- and urinalysis-based approach to diagnosing urinary tract infections in children with neuropathic bladders.

Pediatr Nephrol 2020 05 9;35(5):807-814. Epub 2020 Jan 9.

Department of Epidemiology and Biostatistics, George Washington University, Washington, DC, USA.

Background: Accurately diagnosing urinary tract infections (UTI) in children with neuropathic bladders can be difficult given the lack of specificity of both clinical symptoms and routine screening tests. We aimed to identify a priori unknown classes/groups of children with neuropathic bladder with respect to symptoms and UA results and examine their relationships with odds of UTI.

Methods: We used latent class analysis (LCA) to identify unobserved classes/groups of children with neuropathic bladder based on symptoms and urinalysis (UA) results, respectively. Read More

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http://dx.doi.org/10.1007/s00467-019-04448-8DOI Listing

Acidosis induces antimicrobial peptide expression and resistance to uropathogenic infection in kidney collecting duct cells via HIF-1α.

Am J Physiol Renal Physiol 2020 02 16;318(2):F468-F474. Epub 2019 Dec 16.

Department of Pediatrics, University of Rochester Medical Center, Rochester, New York.

Acute pyelonephritis is frequently associated with metabolic acidosis. We previously reported that metabolic acidosis stimulates expression of hypoxia-inducible factor (HIF)-1α-induced target genes such as stromal derived factor-1 and cathelicidin, an antimicrobial peptide. Since the collecting duct (CD) plays a pivotal role in regulating acid-base homeostasis and is the first nephron segment encountered by an ascending microbial infection, we examined the contribution of HIF-1α to innate immune responses elicited by acid loading of an M-1 immortalized mouse CD cell line. Read More

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http://dx.doi.org/10.1152/ajprenal.00228.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052658PMC
February 2020

Urinary tract infection in pediatrics: an overview.

J Pediatr (Rio J) 2020 Mar - Apr;96 Suppl 1:65-79. Epub 2019 Nov 26.

University of California, Rady Children's Hospital San Diego, Division of Pediatric Nephrology, San Diego, United States.

Objective: This review aimed to provide a critical overview on the pathogenesis, clinical findings, diagnosis, imaging investigation, treatment, chemoprophylaxis, and complications of urinary tract infection in pediatric patients.

Source Of Data: Data were obtained independently by two authors, who carried out a comprehensive and non-systematic search in public databases.

Summary Of Findings: Urinary tract infection is the most common bacterial infection in children. Read More

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http://dx.doi.org/10.1016/j.jped.2019.10.006DOI Listing
November 2019

An Unusual Case of Syringohydromyelia Presenting with Neurogenic Bladder.

European J Pediatr Surg Rep 2019 Jan 22;7(1):e79-e82. Epub 2019 Nov 22.

Department of Pediatric Nephrology, Klinika za djecje bolesti Zagreb Klinika za pedijatriju, Zagreb, Croatia.

We report the case of a 4-year-old boy who first presented with acute pyelonephritis at the age of 6 months. Diagnostic workup revealed high-grade bilateral vesicourethral reflux (VUR). At the age of 18 months, a bulking agent was used to treat bilateral VUR. Read More

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http://dx.doi.org/10.1055/s-0039-1697925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874505PMC
January 2019

Resistance to antibacterial therapy in pediatric febrile urinary tract infections-a single-center analysis.

J Pediatr Urol 2020 Feb 25;16(1):71-79. Epub 2019 Oct 25.

Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany; Center of Medical Information and Communication Technology, University Hospital Erlangen, Erlangen, Germany. Electronic address:

Background: Febrile urinary tract infections (UTIs) are common serious bacterial infections in childhood and require early diagnosis and antibacterial therapy. However, considerable uncertainty exists regarding the optimal antibacterial agent for primary treatment of pediatric UTIs. Additionally, patterns of susceptibility and resistance change over time and microbiological in vitro resistance is not necessarily associated with treatment failure. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.10.018DOI Listing
February 2020

Current status of long-term antibiotic prophylaxis for urinary tract infections in children: An antibiotic stewardship challenge.

Kidney Res Clin Pract 2019 Dec;38(4):441-454

Infectious Diseases Unit, Department of Internal Medicine, King Saud University Medical City, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Recurrent urinary tract infections (UTIs) in children are associated with development of pyelonephritis and renal scarring. Traditionally, continuous antibiotic prophylaxis (CAP) has been used to prevent recurrent UTI. Recent studies have challenged the efficacy of CAP for preventing renal scarring and have raised concerns about inducing bacterial resistance. Read More

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http://dx.doi.org/10.23876/j.krcp.19.091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913590PMC
December 2019

Multicenter Clinical Evaluation of Etest Meropenem-Vaborbactam (bioMérieux) for Susceptibility Testing of () and Pseudomonas aeruginosa.

J Clin Microbiol 2019 12 23;58(1). Epub 2019 Dec 23.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

Meropenem-vaborbactam (MEV) is a novel carbapenem-beta-lactamase inhibitor combination antibiotic approved by the U.S. Food and Drug Administration (FDA) for treatment of complicated urinary tract infections, including pyelonephritis, in adults. Read More

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http://dx.doi.org/10.1128/JCM.01205-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935911PMC
December 2019
1 Read

Non-invasive discrimination of acute focal bacterial nephritis with pyelonephritis.

Pediatr Int 2019 Aug 14;61(8):777-780. Epub 2019 Aug 14.

Department of Pediatrics, Asahikawa-Kosei General Hospital, Asahikawa, Hokkaido, Japan.

Background: The appropriate antimicrobial treatment period for febrile urinary tract infection (UTI) can be changed, depending on whether the patient has acute focal bacterial nephritis (AFBN). The aim of this study was to clarify the characteristics of AFBN compared with those of acute pyelonephritis (APN) and establish a strategy to detect AFBN.

Methods: A total of 77 patients diagnosed with febrile UTI were enrolled. Read More

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http://dx.doi.org/10.1111/ped.13910DOI Listing
August 2019
3 Reads

White blood cell count and eosinopenia as valuable tools for the diagnosis of bacterial infections in the ED.

Eur J Clin Microbiol Infect Dis 2019 Aug 22;38(8):1523-1532. Epub 2019 May 22.

Emergency Department, Hautepierre Hospital, University Hospital of Strasbourg, 1 Avenue Molière, 67200, Strasbourg, France.

Identifying an infection may be difficult in the ED. Neutrophilic leukocytosis is often used in the diagnosis of infection despite its lack of specificity in situations of stress. Our objective was to study the value of each parameter of the WBC count, in particular eosinopenia, to diagnose bacterial infections in the ED. Read More

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http://dx.doi.org/10.1007/s10096-019-03583-2DOI Listing
August 2019
9 Reads

The relationship of seasonality and the increase in urinary tract infections among hospitalized patients with spinal cord injury.

J Chin Med Assoc 2019 May;82(5):401-406

Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Background: Urinary tract infection (UTI) is the most frequent complication in patients who have spinal cord injury (SCI). The occurrence rate of UTI in this type of hospitalized patients was correlated to seasonality, age, and gender.

Methods: Patients hospitalized during the 4-year study period with underlying SCI were identified from Taiwan's National Health Insurance Research Database. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000040DOI Listing
May 2019
8 Reads

Host and Bacterial Markers that Differ in Children with Cystitis and Pyelonephritis.

J Pediatr 2019 06 21;209:146-153.e1. Epub 2019 Mar 21.

Department of Pediatrics, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA; Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA.

Objective: To determine whether treatment for urinary tract infections in children could be individualized using biomarkers for acute pyelonephritis.

Study Design: We enrolled 61 children with febrile urinary tract infections, collected blood and urine samples, and performed a renal scan within 2 weeks of diagnosis to identify those with pyelonephritis. Renal scans were interpreted centrally by 2 experts. Read More

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http://dx.doi.org/10.1016/j.jpeds.2019.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535366PMC
June 2019
16 Reads

Asymptomatic bacteriuria in pregnancy: systematic reviews of screening and treatment effectiveness and patient preferences.

BMJ Open 2019 03 13;9(3):e021347. Epub 2019 Mar 13.

Pediatrics, University of Alberta, Alberta Research Centre for Health Evidence (ARCHE), Edmonton Clinic Health Academy, Edmonton, Alberta, Canada.

Objective: To systematically review screening and treatment effectiveness, and patient preferences, to inform recommendations by the Canadian Task Force on Preventive Health Care on screening for asymptomatic bacteriuria in pregnancy.

Design: We searched multiple databases (inception to September 2017) and grey literature sources for studies on screening effectiveness and patient preferences. For treatment with antibiotics, we searched three databases for systematic reviews and obtained search results of the Cochrane Pregnancy and Childbirth Group's Trials Register to update a Cochrane review. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-021347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429717PMC
March 2019
6 Reads
2.063 Impact Factor

Emphysematous Pyelonephritis Following Ureterovesical Reimplantation for Congenital Obstructive Megaureter. Pediatric Case Report and Review of the Literature.

Front Pediatr 2019 24;7. Epub 2019 Jan 24.

Pediatrics and Adolescentology Unit, Department of Internal Medicine, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Emphysematous pyelonephritis (EPN) is a rare, life-threatening necrotizing infection of the kidney. To date, very few cases of EPN have been described in the pediatric age. The first case of EPN in a toddler occurring after ureterovesical reimplantation for congenital obstructive megaureter is reported with a literature review. Read More

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https://www.frontiersin.org/article/10.3389/fped.2019.00002/
Publisher Site
http://dx.doi.org/10.3389/fped.2019.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354553PMC
January 2019
41 Reads

Vitamin A supplementation is effective for improving the clinical symptoms of urinary tract infections and reducing renal scarring in girls with acute pyelonephritis: a randomized, double-blind placebo-controlled, clinical trial study.

Complement Ther Med 2019 Feb 12;42:429-437. Epub 2018 Dec 12.

Neurology and Neuroscience Research Center, Qom University of Medical Sciences, Qom, Iran.

Introduction: It is believed that tubulointerstitial inflammation plays a role in the formation of renal scarring secondary to acute pyelonephritis (APN). Vitamin A is an anti-inflammatory agent that is involved in the re-epithelialization of damaged mucosal surfaces.

Objective: The aim of this study was to evaluate the efficacy of vitamin A supplementation in combination with antibiotics for improving urinary tract infections (UTIs) symptoms and preventing renal scarring in girls with APN. Read More

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http://dx.doi.org/10.1016/j.ctim.2018.12.007DOI Listing
February 2019
7 Reads
2.216 Impact Factor

Urinary Tract Infection in Children.

Recent Pat Inflamm Allergy Drug Discov 2019 ;13(1):2-18

Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.

Background: Urinary Tract Infection (UTI) is a common infection in children. Prompt diagnosis and appropriate treatment are very important to reduce the morbidity associated with this condition.

Objective: To provide an update on the evaluation, diagnosis, and treatment of urinary tract infection in children. Read More

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http://dx.doi.org/10.2174/1872213X13666181228154940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751349PMC
January 2020
27 Reads

Predictors of grade 3-5 vesicoureteral reflux in infants ≤ 2 months of age with pyelonephritis.

Pediatr Nephrol 2019 05 26;34(5):907-915. Epub 2018 Dec 26.

Department of Pediatrics, Assaf Harofeh Medical Center, 70300, Zerifin, Israel.

Background: This study aimed to assess predictors for grade 3-5 vesicoureteral reflux (VUR) in infants ≤ 2 months of age admitted for first urinary tract infection (UTI).

Methods: Retrospective cohort study of 195 infants ≤ 2 months admitted to a pediatric ward for first UTI between 2006 and 2017. Clinical, laboratory, and imaging data were collected from electronic medical charts. Read More

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http://dx.doi.org/10.1007/s00467-018-4167-0DOI Listing
May 2019
8 Reads

Ureaplasma urealyticum pyelonephritis presenting with progressive dysuria, renal failure, and neurologic symptoms in an immunocompromised patient.

Transpl Infect Dis 2019 Apr 10;21(2):e13032. Epub 2018 Dec 10.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri.

Ureaplasma urealyticum is a bacterial species correlated with urethritis in healthy individuals and invasive infections in immunocompromised patients. We describe a 20-year-old female with a history of remote heart transplant on everolimus, mycophenolate, and rituximab presenting with progressive urinary tract symptoms, renal failure, and neurologic symptoms. An extensive workup ultimately identified U urealyticum infection, and the patient successfully recovered after a course of azithromycin and doxycycline. Read More

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http://dx.doi.org/10.1111/tid.13032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542459PMC
April 2019
14 Reads

Urinary Tract Infections.

Pediatr Clin North Am 2019 02;66(1):1-13

Nephrology Section, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA; Department of Pediatrics, Ohio State University School of Medicine, 700 Children's Drive, Columbus, OH 43210, USA; Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, W308, Columbus, OH 43205, USA. Electronic address:

Urinary tract infection (UTI) is the second most common bacterial infection in children and is considered a public health threat given the mounting rates of antibiotic-resistance among uropathogens. This article highlights recent encouraging developments in UTI research. Further work is necessary to translate the discoveries into accessible, cost-effective technologies that will aid clinicians in real-time decision-making. Read More

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http://dx.doi.org/10.1016/j.pcl.2018.08.002DOI Listing
February 2019
24 Reads

Insulin receptor signaling regulates renal collecting duct and intercalated cell antibacterial defenses.

J Clin Invest 2018 12 12;128(12):5634-5646. Epub 2018 Nov 12.

Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.

People with diabetes mellitus have increased infection risk. With diabetes, urinary tract infection (UTI) is more common and has worse outcomes. Here, we investigate how diabetes and insulin resistance impact the kidney's innate defenses and urine sterility. Read More

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https://www.jci.org/articles/view/98595
Publisher Site
http://dx.doi.org/10.1172/JCI98595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264632PMC
December 2018
36 Reads

Fever duration during treated urinary tract infections and development of permanent renal lesions.

Arch Dis Child 2019 05 2;104(5):466-470. Epub 2018 Nov 2.

Department of Nephrology, "P&A Kyriakou" Children's Hospital, Athens, Greece.

Objective: To assess the effect of the duration of fever after the initiation of treatment (FAT) of febrile urinary tract infections (UTI) on the development of permanent renal lesions based on dimercaptosuccinic acid (DMSA) scintigraphy findings. To evaluate the FAT contribution to permanent renal lesion formation in relation to fever before treatment initiation (FBT), the presence of vesicourinary reflux (VUR), age and severity of infection.

Methods: The inpatient records of 148 children (median age: 2. Read More

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http://dx.doi.org/10.1136/archdischild-2017-314576DOI Listing
May 2019
10 Reads

Renal Mucormycosis: A Rare Cause of Urinary Tract Infection Leading to End-stage Renal Disease (ESRD).

J Trop Pediatr 2019 08;65(4):405-408

Professor and Head, Division of Pediatric Nephrology and Pediatrics Unit II, Christian Medical College, Vellore, Tamil Nadu, India.

Mucormycosis is a rare fungal infection often seen in immunocompromised hosts. Isolated renal mucormycosis may however present in immunocompetent children as renal failure and has a uniformly poor prognosis if not detected and treated early into the course of illness. We present a 3-year-old boy with unrelenting pyelonephritis in whom serial urine cultures done were negative. Read More

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https://academic.oup.com/tropej/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/tropej/fmy059DOI Listing
August 2019
9 Reads

Antinatriuretic phenomena seen in children with acute pyelonephritis may be related to the activation of intrarenal RAAS.

Medicine (Baltimore) 2018 Sep;97(36):e12152

Department of Pediatrics.

We investigated whether antinatriuretic phenomena [decreases in urinary sodium (uNa) and fractional excretion of sodium (FENa)] seen in children with acute pyelonephritis (APN) are associated with the renin-angiotensin-aldosterone system (RAAS).We examined 114 children experiencing their first episode of febrile urinary tract infection (fUTI) consecutively admitted to our hospital from July 2012 to June 2014. Blood tests [C-reactive protein, white blood cell count, erythrocyte sedimentation rate, and aldosterone (Aldo)] and urine tests [uNa, urine potassium (uK) and FENa] were performed upon admission. Read More

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http://dx.doi.org/10.1097/MD.0000000000012152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133464PMC
September 2018
26 Reads

Novel role for androgen signaling in pyelonephritis.

Kidney Int 2018 09;94(3):455-457

Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA; Division of Nephrology, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA. Electronic address:

Sex differences in urinary tract infection (UTI) susceptibility and severity are known, but have historically focused on anatomic differences between males and females. Until recently, experimental UTI has been limited to female animals due to ease of transurethral bladder catheterization. Olson and colleagues have developed a model of experimental UTI independent of sex that relies on direct bladder inoculation and thus permits investigation of sex differences in UTI susceptibility. Read More

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http://dx.doi.org/10.1016/j.kint.2018.05.020DOI Listing
September 2018
7 Reads

Discovery of New Genes Involved in Curli Production by a Uropathogenic Escherichia coli Strain from the Highly Virulent O45:K1:H7 Lineage.

mBio 2018 08 21;9(4). Epub 2018 Aug 21.

School of Chemistry and Molecular Biosciences, the University of Queensland, Brisbane, Queensland, Australia

Curli are bacterial surface-associated amyloid fibers that bind to the dye Congo red (CR) and facilitate uropathogenic (UPEC) biofilm formation and protection against host innate defenses. Here we sequenced the genome of the curli-producing UPEC pyelonephritis strain MS7163 and showed it belongs to the highly virulent O45:K1:H7 neonatal meningitis-associated clone. MS7163 produced curli at human physiological temperature, and this correlated with biofilm growth, resistance of sessile cells to the human cationic peptide cathelicidin, and enhanced colonization of the mouse bladder. Read More

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http://dx.doi.org/10.1128/mBio.01462-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106082PMC
August 2018
25 Reads

Androgen exposure potentiates formation of intratubular communities and renal abscesses by Escherichia coli.

Kidney Int 2018 09 3;94(3):502-513. Epub 2018 Jul 3.

Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address:

Females across their lifespan and certain male populations are susceptible to urinary tract infections (UTI). The influence of female vs. male sex on UTI is incompletely understood, in part because preclinical modeling has been performed almost exclusively in female mice. Read More

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http://dx.doi.org/10.1016/j.kint.2018.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109434PMC
September 2018
8 Reads

Bilateral multifocal acute lobar nephronia caused by .

BMJ Case Rep 2018 Apr 5;2018. Epub 2018 Apr 5.

Department of Paediatrics, Fuji City General Hospital, Shizuoka, Japan.

An 8-year-old boy presented to our hospital with complaints of fever, epigastric pain and headache. were isolated from urine and blood culture, bacteraemic urinary tract infection was clinically diagnosed. Although vancomycin and ampicillin were administrated, fever did not subside. Read More

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http://dx.doi.org/10.1136/bcr-2018-224336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893980PMC
April 2018
9 Reads

7-day compared with 10-day antibiotic treatment for febrile urinary tract infections in children: protocol of a randomised controlled trial.

BMJ Open 2018 03 2;8(3):e019479. Epub 2018 Mar 2.

Department of Paediatric Nephrology, The Medical University of Warsaw, Warsaw, Poland.

Introduction: The optimal duration of antibiotic therapy in children with febrile urinary tract infections (UTIs) is still a matter of debate. Current guidelines recommend treating children with febrile UTIs with antimicrobials for 7 to 14 days. We aim to compare the efficacy and safety of 7-day versus 10-day course of oral or sequence therapy (intravenous with a switch to oral) with cefuroxime/cefuroxime axetil for febrile UTIs in children. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-019479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855174PMC
March 2018
20 Reads

Interleukin-6/Stat3 signaling has an essential role in the host antimicrobial response to urinary tract infection.

Kidney Int 2018 06 21;93(6):1320-1329. Epub 2018 Feb 21.

Research Institute at Nationwide Children's Hospital, Center for Clinical and Translational Research, Columbus, Ohio, USA; Nephrology Section, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA. Electronic address:

The signaling networks regulating antimicrobial activity during urinary tract infection (UTI) are incompletely understood. Interleukin-6 (IL-6) levels increase with UTI severity, but the specific contributions of IL-6 to host immunity against bacterial uropathogens are unknown. To clarify this we tested whether IL-6 activates the Stat3 transcription factor, to drive a program of antimicrobial peptide gene expression in infected urothelium during UTI. Read More

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http://dx.doi.org/10.1016/j.kint.2017.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967986PMC
June 2018
44 Reads

Bilateral Obstructive Uropathy Caused by Congenital Bladder Diverticulum Presenting as Hypertensive Retinopathy.

J Korean Med Sci 2018 Feb 19;33(8):e54. Epub 2018 Feb 19.

Department of Pediatrics, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.

A congenital bladder diverticulum (CBD) is caused by inherent muscular weakness instead of obstruction of the bladder outlet. The major clinical conditions are recurrent urinary tract infection (UTI) and voiding dysfunction. This report describes a 15-year-old male adolescent who developed sudden visual disturbance resulting from hypertensive retinopathy. Read More

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http://dx.doi.org/10.3346/jkms.2018.33.e54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809749PMC
February 2018
17 Reads

Vitamin D deficiency is associated with urinary tract infection in children.

Arch Med Sci 2018 Jan 26;14(1):115-121. Epub 2016 Oct 26.

Department of Clinical and Chemical Pathology, Faculty of Medicine, Port Said University, Port Said, Egypt.

Introduction: In humans, vitamin D has been shown to play a role in infectious diseases, but its association with acquisition and a complicated course of febrile urinary tract infections (UTIs) has not been investigated. We aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D) levels and the risk of first time febrile UTI in children.

Material And Methods: This prospective case-control study included 50 children with first febrile UTI, with no risk factors for UTI, and 50 age- and sex-matched healthy siblings as controls. Read More

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http://dx.doi.org/10.5114/aoms.2016.63262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778422PMC
January 2018
27 Reads

D-dimer as a marker of acute pyelonephritis in infants younger than 24 months with urinary tract infection.

Pediatr Nephrol 2018 04 6;33(4):631-637. Epub 2018 Jan 6.

Department of Pediatrics, Yonsei University College of Medicine, Yonsei-ro 50, Seodaemun-gu, C.P.O. Box 8044, Seoul, 120-752, South Korea.

Background: D-dimer, as well as other biomarkers related to coagulation, is significantly increased during severe bacterial infection and sepsis. The aim of this study was to evaluate the usefulness of serum D-dimer as a biological marker in diagnosing acute pyelonephritis (APN) and in predicting vesicoureteric reflux (VUR) in infants with urinary tract infection (UTI).

Methods: We retrospectively analyzed the data of 177 young infants (<2 years) with febrile UTI between 2005 and 2014, grouped as APN and lower UTI groups. Read More

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http://dx.doi.org/10.1007/s00467-017-3843-9DOI Listing
April 2018
107 Reads
2.860 Impact Factor

The urinary and serum levels of IL-32 in children with febrile urinary tract infections.

Future Sci OA 2017 Nov 14;3(4):FSO242. Epub 2017 Sep 14.

Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Aim: We assessed the urinary and serum levels of IL-32 in pediatric patients with acute pyelonephritis (APN) with and without renal scarring.

Results: We enrolled children aged 2 months to 16 years with APN. Dimercaptosuccinic acid scans and ultrasonography studies were ordered for all patients, and a voiding. Read More

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http://www.future-science.com/doi/10.4155/fsoa-2017-0076
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http://dx.doi.org/10.4155/fsoa-2017-0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674269PMC
November 2017
24 Reads

Discrimination of culture negative pyelonephritis in children with suspected febrile urinary tract infection and negative urine culture results.

Authors:
Jun Ho Lee

J Microbiol Immunol Infect 2019 Aug 25;52(4):598-603. Epub 2017 Oct 25.

Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, South Korea. Electronic address:

Background: We investigated whether the C-reactive protein (CRP) level, urine electrolytes, and urine sodium-potassium ratio (uNa/K) could be useful markers for discriminating children with culture negative pyelonephritis (CNP) from children with suspected febrile urinary tract infection (fUTI) and negative urine culture results.

Methods: We examined 264 children experiencing their first fUTI consecutively admitted to our hospital between January 2011 and October 2014. Blood tests (CRP, white blood cell count [WBC], erythrocyte sedimentation rate [ESR], electrolytes) and urine tests (urine protein to creatinine ratio [uProt/Cr], electrolytes, uNa/K) were performed upon admission. Read More

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http://dx.doi.org/10.1016/j.jmii.2017.09.005DOI Listing
August 2019
6 Reads

Routine prophylaxis is not necessary to prevent renal scarring in children with urinary tract infection.

Evid Based Med 2017 12 22;22(6):208. Epub 2017 Oct 22.

Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA.

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http://dx.doi.org/10.1136/ebmed-2017-110784DOI Listing
December 2017
13 Reads

The clinical diagnosis and management of urinary tract infections in children and adolescents.

Paediatr Int Child Health 2017 Nov 5;37(4):273-279. Epub 2017 Oct 5.

c Department of Pediatrics, Division of Nephrology , Nationwide Children's Hospital , Columbus , OH , USA.

Urinary tract infections (UTI) are one of the most common and serious bacterial infections encountered by paediatricians and primary care physicians. Although the diagnosis and management of UTI appear simplistic, they remain among the most contentious issues in paediatrics. In part, UTI controversies stem from the absence of classic clinical symptoms, inappropriate urine specimen collection, modified urinary tract imaging recommendations, and diverse treatment and prevention strategies. Read More

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http://dx.doi.org/10.1080/20469047.2017.1382046DOI Listing
November 2017
6 Reads

An update on new antibiotic prophylaxis and treatment for urinary tract infections in children.

Expert Opin Pharmacother 2017 Oct 27;18(15):1619-1625. Epub 2017 Sep 27.

a Pediatric Nephrology Unit , Trousseau Hospital and DHU i2B Inflammation-Immunopathology-Biotherapy , Paris , France.

Introduction: This review focuses on the treatment of urinary tract infections (UTI) in children and in particular its recent changes. Areas covered: Acute pyelonephritis, acute cystitis and asymptomatic bacteriuria or asymptomatic infections have to be clearly distinguished. Prompt treatment is required in pyelonephritis and cystitis, but not in asymptomatic bacteriuria or infection, in order to avoid selection of more virulent strains. Read More

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http://dx.doi.org/10.1080/14656566.2017.1383383DOI Listing
October 2017
18 Reads

Decreased Identification of Vesicoureteral Reflux: A Cautionary Tale.

Front Pediatr 2017 11;5:175. Epub 2017 Aug 11.

Innate Immunity Translational Research Center, Children Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN, United States.

Aim: To find the trend in patient's visits to our centers for vesicoureteral reflux (VUR). We hypothesize that VUR diagnosis and hence possible nephropathy recognition may be diminishing because of changing practice patterns.

Methods: Data were extracted from electronic medical records for new and follow-up patients aged 0-18 years with ICD-9/10 codes to correspond with VUR, VUR unilateral, VUR bilateral, and VUR with reflux nephropathy, as well as new patients with diagnoses of urinary tract infections (UTI) and pyelonephritis at two major pediatric centers from 2012 to 2015. Read More

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http://dx.doi.org/10.3389/fped.2017.00175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554494PMC
August 2017
32 Reads

Recent Studies on the Care of First Febrile Urinary Tract Infection in Infants and Children for the Pediatric Hospitalist.

Rev Recent Clin Trials 2017 ;12(4):269-276

Department of Pediatrics, University of North Carolina School of Medicine, 101 Manning Drive, CB # 7220, Chapel Hill, NC, 27514. United States.

Background: Urinary Tract Infection (UTI) is a common cause of bacterial infection in young children, and accounts for a significant number of pediatric hospitalizations.

Objective: To review recent publications focusing on the care of children hospitalized with their first febrile UTI.

Methods: A PubMed search was performed including publications from 2011-2016 on first febrile UTI in childhood. Read More

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http://dx.doi.org/10.2174/1574887112666170816143639DOI Listing
August 2018
22 Reads