2,379 results match your criteria Pediatrics Tachycardia


Inappropriate Sinus Tachycardia: Current Challenges and Future Directions.

J Innov Card Rhythm Manag 2018 Jul 15;9(7):3239-3243. Epub 2018 Jul 15.

Division of Cardiovascular Disease, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.19102/icrm.2018.090706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252682PMC

Pathophysiological effects of intravenous phosphodiesterase type 4 inhibitor in addition to surfactant lavage in meconium-injured newborn piglet lungs.

Pediatr Pulmonol 2020 Jun 1. Epub 2020 Jun 1.

Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: Nonsteroidal anti-inflammatory drugs such as selective phosphodiesterase type 4 (PDE4) inhibitors have potential anti-inflammatory and respiratory smooth muscle relaxation effects. This study aimed to investigate the pathophysiological effects of an intravenous PDE4 inhibitor (rolipram) and surfactant lavage (SL) in a newborn piglet model of meconium aspiration syndrome (MAS).

Methods: MAS was induced in 25 newborn piglets, which were randomly divided into control and four SL treatment groups administered with different doses of intravenous rolipram (0, 0. Read More

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http://dx.doi.org/10.1002/ppul.24880DOI Listing

A Population-Based Registry of Patients With Inherited Cardiac Conditions and Resuscitated Cardiac Arrest.

J Am Coll Cardiol 2020 Jun;75(21):2698-2707

Greenlane Paediatric and Congenital Cardiac Services, Starship Children's Hospital, Auckland, New Zealand; Cardiac Inherited Disease Group, Auckland, New Zealand; Department of Paediatrics Child and Youth Health, University of Auckland, Auckland, New Zealand. Electronic address:

Background: The relative proportion of each cardiac inherited disease (CID) causing resuscitated sudden cardiac arrest (RSCA) on a population basis is unknown.

Objectives: This study describes the profile of patients with CIDs presenting with RSCA; their data were collected by the national Cardiac Inherited Diseases Registry New Zealand (CIDRNZ).

Methods: Data were collated from CIDRNZ probands presenting with RSCA (2002 to 2018). Read More

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http://dx.doi.org/10.1016/j.jacc.2020.04.004DOI Listing

Heart Rate and Heart Rate Difference Predicted the Efficacy of Metoprolol on Postural Tachycardia Syndrome in Children and Adolescents.

J Pediatr 2020 May 25. Epub 2020 May 25.

Department of Pediatric Cardiovasology, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address:

Objective: To evaluate the ability of heart rate (HR) and HR difference during head-up tilt test (HUTT). To predict clinical improvement related to metoprolol treatment in children and adolescents with postural tachycardia syndrome (POTS).

Study Design: This was a retrospective cohort study. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.05.017DOI Listing

Supraventricular tachyarrhythmias during the intrauterine, neonatal and infant period: A 10-year population-based study.

Pacing Clin Electrophysiol 2020 May 27. Epub 2020 May 27.

Slovak Medical University, Bratislava, Slovakia.

Background: We aimed to evaluate the incidence, type and management of supraventricular tachyarrhythmias (SVT) during the first year of life in a retrospective, population-based, single-center study during a 10-year period.

Methods: The analyzed patient cohort is based on data from the only specialized center managing all cases of neonatal and infant SVTs between 2009 and 2018 in the Slovak Republic (5.5 million population). Read More

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http://dx.doi.org/10.1111/pace.13964DOI Listing

Arterial Hypertension in Children.

Handb Exp Pharmacol 2020 May 27. Epub 2020 May 27.

Department for Pediatric Cardiology, University of Leipzig - Heart Center, Leipzig, Germany.

Pharmacological treatment of arterial hypertension in children is mainly based on individual experience, but there is evidence that blocking the angiotensin system reduces systolic and diastolic blood when compared to placebo, and these drugs are safe to use for a short duration, also in children under 6 years of age. Blocking the angiotensin system either by angiotensin-converting enzyme inhibitors or by antagonizing the angiotensin 1 receptor is effective, but did not display a consistent dose-response relationship with escalating doses, but the effective doses are known. Calcium channel antagonists are effective antihypertensives in children, but the evidence is limited. Read More

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http://dx.doi.org/10.1007/164_2020_359DOI Listing

[Vasovagal syncope or postural orthostatic tachycardia syndrome in children with neurological symptoms at disease onset: a clinical analysis of 88 cases].

Zhongguo Dang Dai Er Ke Za Zhi 2020 May;22(5):488-493

Department of Pediatrics, Second Xiangya Hospital of Central South University, Changsha 410011, China.

Objective: To study the clinical features of vasovagal syncope (VVS) and postural orthostatic tachycardia syndrome (POTS) in children with neurological symptoms at disease onset.

Methods: A retrospective analysis was performed on the medical data of 88 children with the initial symptoms of the nervous system, such as transient loss of consciousness, dizziness, headache, and convulsion, who were finally diagnosed with VVS or POTS.

Results: Of the 88 children, there were 35 boys (40%) and 53 girls (60%), with an age of 4-15 years. Read More

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ACUTE INFLAMMATION AND ELEVATED CARDIAC MARKERS IN A TWO-MONTH-OLD INFANT WITH SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 INFECTION PRESENTING WITH CARDIAC SYMPTOMS.

Pediatr Infect Dis J 2020 May 19. Epub 2020 May 19.

Department of Pediatrics, ASST-FBF-Sacco, Vittore Buzzi Children's Hospital, University of Milan, Milan, Italy.

Severe acute respiratory syndrome coronavirus 2 infection in children mainly shows a milder course. In complicated cases, it is unknown whether inflammation is predictive of disease severity, as in adults. Moreover, cardiac involvement is anecdotally described. Read More

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http://dx.doi.org/10.1097/INF.0000000000002750DOI Listing

Complex and Novel Arrhythmias Precede Stillbirth in Fetuses With De Novo Long QT Syndrome.

Circ Arrhythm Electrophysiol 2020 May 18;13(5):e008082. Epub 2020 May 18.

Department of Medical Physics, University of Wisconsin-Madison (S.S. R.T.W.).

Background: Long QT syndrome (LQTS) is a leading cause of sudden cardiac death in early life and has been implicated in ≈10% of sudden infant deaths and unexplained stillbirths. The purpose of our study was to use fetal magnetocardiography to characterize the electrophysiology and rhythm phenotypes of fetuses with de novo and inherited LQTS variants and identify risk factors for sudden death before birth.

Methods: We reviewed the fetal magnetocardiography database from the University of Wisconsin Biomagnetism Laboratory for fetuses with confirmed LQTS. Read More

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http://dx.doi.org/10.1161/CIRCEP.119.008082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241276PMC

Percutaneous Atrial Septal Defect Closure in Adult Ebstein's Anomaly with Exertional Hypoxemia.

Int Heart J 2020 May 15;61(3):620-623. Epub 2020 May 15.

Department of Pediatrics, Jichi Medical University.

In Ebstein's anomaly, percutaneous atrial septal defect (ASD) closure for the treatment of hypoxemia due to a right-to-left interatrial shunt remains controversial. We report the case of a 40-year-old woman with Ebstein's anomaly who developed cyanosis and shortness of breath on exercise. Her symptoms improved after percutaneous ASD closure and her clinical course has been good during follow-up. Read More

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http://dx.doi.org/10.1536/ihj.19-641DOI Listing

A Validated Model for Sudden Cardiac Death Risk Prediction in Pediatric Hypertrophic Cardiomyopathy.

Circulation 2020 May 18. Epub 2020 May 18.

Division of Cardiology, Hospital for Sick Children, Toronto, ON, Canada; Department of Cardiology, Labatt Family Heart Centre, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Hypertrophic cardiomyopathy (HCM) is the leading cause of sudden cardiac death (SCD) in children and young adults. Our objective was to develop and validate a SCD risk prediction model in pediatric HCM to guide SCD prevention strategies. In an international multi-center observational cohort study, phenotype-positive patients with isolated HCM <18 years at diagnosis were eligible. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.120.047235DOI Listing
May 2020
14.430 Impact Factor

Risk Factors for Mortality and Ventricular Tachycardia in Patients With Repaired Tetralogy of Fallot: A Systematic Review and Meta-analysis.

Can J Cardiol 2020 Feb 4. Epub 2020 Feb 4.

Heart Institute, Cincinnati Children`s Hospital Medical Center, Cincinnati, Ohio, USA; University of Cincinnati College of Medicine, Department of Pediatrics, Cincinnati, Ohio, USA. Electronic address:

Background: Patients with repaired tetralogy of Fallot (rTOF) have increased risk for mortality, sudden cardiac death, and ventricular tachycardia (VT). The aim of this systematic review and meta-analysis is to offer an updated analysis of risk factors following significant changes in surgical and perioperative management.

Methods: A meta-analysis based on the published literature between 2008 and 2018 was conducted. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.01.023DOI Listing
February 2020

Acute kidney injury in dengue among hospitalized children: A prospective view.

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):407-414

Department of Pediatrics, VMMC and Safdarjung Hospital, New Delhi, India.

Dengue viral infection (DVI) has emerged as one of the most common arthropod borne diseases and is more prevalent in the tropical countries. It has varied clinical spectrum ranging from undifferentiated fever to severe hemorrhagic fever and shock with multi-organ dysfunction. Acute kidney injury (AKI) is lesser known complication in DVI. Read More

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http://dx.doi.org/10.4103/1319-2442.284015DOI Listing

Wearable cardioverter-defibrillator as bridging to ICD in pediatric hypertrophic cardiomyopathy with myocardial bridging - a case report.

BMC Pediatr 2020 May 11;20(1):207. Epub 2020 May 11.

Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Graz, Austria.

Background: There is only limited experience with wearable cardioverter-defibrillators (WCD) in pediatric patients. We report on the successful application of a WCD in an adolescent patient with hypertrophic cardiomyopathy and myocardial bridging.

Case Presentation: A 15-year-old girl presented with a history of recurrent syncope, dyspnea, and vertigo with exercise. Read More

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http://dx.doi.org/10.1186/s12887-020-02113-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212673PMC

A novel TRPM6 variant (c.3179T>A) causing familial hypomagnesemia with secondary hypocalcemia.

Endocrinol Diabetes Metab Case Rep 2020 May 5;2020. Epub 2020 May 5.

Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal.

Summary: Familial hypomagnesemia with secondary hypocalcemia (FHSH) is a rare autosomal recessive disorder (OMIM# 602014) characterized by profound hypomagnesemia associated with hypocalcemia. It is caused by mutations in the gene encoding transient receptor potential cation channel member 6 (TRPM6). It usually presents with neurological symptoms in the first months of life. Read More

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http://dx.doi.org/10.1530/EDM-20-0005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219130PMC

Pathophysiology and Individualized Management of Vasovagal Syncope and Postural Tachycardia Syndrome in Children and Adolescents: An Update.

Authors:
Ying Liao Junbao Du

Neurosci Bull 2020 May 4. Epub 2020 May 4.

Department of Pediatrics, Peking University First Hospital, Beijing, 100034, China.

Vasovagal syncope (VVS) and postural tachycardia syndrome (POTS) are the main forms of orthostatic intolerance in pediatrics and both are underlying causes of neurally-mediated syncope. In recent years, increasing attention has been paid to the management of VVS and POTS in children and adolescents. A number of potential mechanisms are involved in their pathophysiology, but the leading cause of symptoms varies among patients. Read More

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http://dx.doi.org/10.1007/s12264-020-00497-4DOI Listing

The Efficacy and Safety of Radiofrequency Catheter Ablation for Cardiac Arrhythmias in Pediatric Patients.

Heart Surg Forum 2020 03 11;23(2):E114-E117. Epub 2020 Mar 11.

Department of Paediatrics, Renmin Hospital of Wuhan University, Wuhan, China.

Background: We aimed to evaluate the acute and long-term efficacy and safety of radiofrequency catheter ablation (RFCA) in Chinese pediatric patients with arrhythmias.

Methods: We gathered clinical data from pediatric patients who underwent RFCA in several large medical centers in China between 2000 and 2019.

Results: A total of 4,622 different substrates in 4,622 patients were ablated, with the majority consisting of supraventricular tachycardia (N = 3,831, 82. Read More

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http://dx.doi.org/10.1532/hsf.2837DOI Listing

KCNQ2-Neonatal Epileptic Encephalopathy Complicated by Ventricular Tachycardia: A Case Report.

Front Neurol 2020 17;11:263. Epub 2020 Apr 17.

Department of Pediatrics, Peking University First Hospital, Beijing, China.

Mutations in are related to a spectrum of neonatal epileptic phenotypes. Here we report a case of KCNQ2-related neonatal epileptic encephalopathy (KCNQ2-NEE) that is complicated by an incidentally found ventricular tachycardia. An infant boy presented with very early onset refractory focal tonic seizures and developmental delay, and was diagnosed with epilepsy. Read More

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http://dx.doi.org/10.3389/fneur.2020.00263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180217PMC

Cardiac complications in patients who underwent to hematopoietic stem cell transplantation.

J Cancer Res Ther 2020 Jan-Mar;16(1):53-59

Department of Pediatrics, Division of Pediatric Oncology, Hacettepe University Faculty of Medicine and Cancer Institute, Ankara, Turkey.

Aim Of Study: Cardiac complications may be observed after hematopoietic stem cell transplantation (HSCT). Despite significant improvement in supportive care, HSCT may be associated with significant morbidity and mortality. In this study, the aim was to evaluate the frequency of clinically serious cardiac complications after HSCT in our patients. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_314_17DOI Listing

Midazolam intoxication in a premature neonate.

Clin Ther 2020 Apr 27. Epub 2020 Apr 27.

Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.

Purpose: We report the case of a male neonate with a respiratory disorder who developed adverse cardiorespiratory symptoms after the continuous infusion of midazolam.

Methods: To clarify the cause of cardiogenic shock, we performed whole exome sequencing and screened relative single-nucleotide variants of 2 cytochrome P450 (CYP) isoforms, CYP3A4 and CYP3A5, which play a dominant role in the metabolic elimination of midazolam. We measured endogenous cortisol 6β-hydroxylation clearance to phenotypically assess CYP3A activity. Read More

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http://dx.doi.org/10.1016/j.clinthera.2020.03.013DOI Listing

Value of provocative electrophysiology testing in the management of pediatric patients after congenital heart surgery.

Pacing Clin Electrophysiol 2020 Apr 24. Epub 2020 Apr 24.

Department of Cardiology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School.

Objective: To determine the impact of provocative electrophysiology testing in post-operative congenital heart disease (CHD) patients on the management of supraventricular tachycardia (SVT) and clinical outcomes.

Methods: This is a retrospective study including patients < 18 years of age with surgery for CHD who had post-operative SVT between 2006-2017. Post-operative outcomes were compared between patients with and without post-operative electrophysiology testing using the Wilcoxon rank sum test, Fisher's exact test, Kaplan-Meier method with the log-rank test and Cox proportional hazard model. Read More

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http://dx.doi.org/10.1111/pace.13925DOI Listing

An Exciting New Tool in the Electrophysiologist's Toolbox, Intravenous Sotalol: Faster, Safer, Better?

JACC Clin Electrophysiol 2020 Apr;6(4):433-435

Department of Pediatric Cardiology, University of Utah, and Primary Children's Hospital, Salt Lake City, Utah.

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http://dx.doi.org/10.1016/j.jacep.2019.12.016DOI Listing

Intravenous Sotalol in the Young: Safe and Effective Treatment With Standardized Protocols.

JACC Clin Electrophysiol 2020 Apr 26;6(4):425-432. Epub 2020 Feb 26.

Division of Pediatric Cardiology, Department of Pediatrics, University of California-San Diego School of Medicine, Rady Children's Hospital, San Diego, California.

Objectives: This study assessed the safety and efficacy of novel and standardized protocols for the use of intravenous (IV) sotalol in pediatric patients.

Background: Acute arrhythmia treatments in children remain limited. IV sotalol is a new option but pediatric experience is limited. Read More

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http://dx.doi.org/10.1016/j.jacep.2019.11.019DOI Listing

Thyroid storm with encephalopathy and cardiovascular symptoms refractory to medical management in an adolescent.

Int J Crit Illn Inj Sci 2020 Jan-Mar;10(1):38-41. Epub 2020 Mar 6.

Division of Pediatric Critical Care Medicine, Department of Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA.

Thyroid storm (TS) is rare in pediatrics, most cases reported in literature responded well to medical therapy. We report the case of an adolescent female presented with TS refractory to anti-thyroid medical management. She had refractory hypertension, tachycardia, and progressive encephalopathy despite aggressive medical management. Read More

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http://dx.doi.org/10.4103/IJCIIS.IJCIIS_58_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170342PMC

Recurrent single echo beats after cryoablation of atrioventricular nodal reentrant tachycardia: The pediatric population.

Indian Pacing Electrophysiol J 2020 Apr 18. Epub 2020 Apr 18.

Division of Pediatric Cardiology, Department of Pediatrics, Children's Healthcare of Atlanta, Atlanta, GA, USA.

Background: Cryoablation for atrioventricular nodal reentrant tachycardia (AVNRT) is effective and safe with a reported limitation of lower success and higher recurrence rates. We have observed cases in which slow pathway conduction was eliminated as demonstrated by atrial extra-stimulus testing within 1 min of cryo-energy delivery but returned following tissue rewarming. Frequently, slow pathway conduction persisted despite multiple acutely successful lesions over a broad anatomic region. Read More

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http://dx.doi.org/10.1016/j.ipej.2020.04.007DOI Listing

Epidemiology and Outcomes of Acute Decompensated Heart Failure in Children.

Circ Heart Fail 2020 Apr 17;13(4):e006101. Epub 2020 Apr 17.

Division of Cardiology (J.J.L., A.G.C., J.F.P.), Texas Children's Hospital, Baylor College of Medicine, Houston.

Background: Acute decompensated heart failure (ADHF) is a highly morbid condition among adults. Little is known about outcomes in children with ADHF. We analyzed the Pediatric Cardiac Critical Care Consortium registry to determine the epidemiology, contemporary treatments, and predictors of mortality in critically ill children with ADHF. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.119.006101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169981PMC

Cardiac-cerebral-renal associations in pediatric traumatic brain injury: Preliminary findings.

J Clin Neurosci 2020 Apr 13. Epub 2020 Apr 13.

Department of Anesthesiology and Pain Medicine, Harborview Injury Prevention and Research Center, Harborview Medical Center, Seattle, WA, United States.

Objective: The clinical epidemiology of organ outcomes in pediatric traumatic brain injury (TBI) has not been examined. We describe associated markers of cerebral, cardiac and renal injury after pediatric TBI.

Design: Prospective observational study. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.04.021DOI Listing

Natural History and Risk Stratification in Andersen-Tawil Syndrome Type 1.

J Am Coll Cardiol 2020 Apr;75(15):1772-1784

Molecular Cardiology, IRCCS ICS Maugeri, Pavia, Italy; Department of Molecular Medicine, University of Pavia, Pavia, Italy; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart; Molecular Cardiology, Fundación Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain. Electronic address:

Background: Andersen-Tawil Syndrome type 1 (ATS1) is a rare arrhythmogenic disorder, caused by loss-of-function mutations in the KCNJ2 gene. We present here the largest cohort of patients with ATS1 with outcome data reported.

Objectives: This study sought to define the risk of life-threatening arrhythmic events (LAE), identify predictors of such events, and define the efficacy of antiarrhythmic therapy in patients with ATS1. Read More

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http://dx.doi.org/10.1016/j.jacc.2020.02.033DOI Listing
April 2020
16.503 Impact Factor

Cardiopulmonary failure in children infected with Enterovirus A71.

J Biomed Sci 2020 Apr 16;27(1):53. Epub 2020 Apr 16.

Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, No. 5, Fuxing Street, Guishan District, Taoyuan, 333, Taiwan.

Enterovirus A71 (EV-A71) is one of the causative pathogens of hand, foot, and mouth disease (HFMD), which may cause severe neurological and cardiopulmonary complications in children. In this review, we discuss the pathogenesis, clinical manifestations, management strategy, and clinical outcomes of cardiopulmonary failure (CPF) in patients with EV-A71 infection.The pathogenesis of CPF involves both catecholamine-related cardiotoxicity following brainstem encephalitis and vasodilatory shock due to cytokine storm. Read More

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http://dx.doi.org/10.1186/s12929-020-00650-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161201PMC

The Impact of a Tablet App on Adherence to American Heart Association Guidelines During Simulated Pediatric Cardiopulmonary Resuscitation: Randomized Controlled Trial.

J Med Internet Res 2020 May 27;22(5):e17792. Epub 2020 May 27.

Diagnostic Department, Geneva University Hospitals, Geneva, Switzerland.

Background: Evidence-based best practices are the cornerstone to guide optimal cardiopulmonary arrest resuscitation care. Adherence to the American Heart Association (AHA) guidelines for cardiopulmonary resuscitation (CPR) optimizes the management of critically ill patients and increases their chances of survival after cardiac arrest. Despite advances in resuscitation science and survival improvement over the last decades, only approximately 38% of children survive to hospital discharge after in-hospital cardiac arrest and only 6%-20% after out-of-hospital cardiac arrest. Read More

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http://dx.doi.org/10.2196/17792DOI Listing
May 2020
3.428 Impact Factor

The impact of physical activity modification on the well-being of a cohort of children with an inherited arrhythmia or cardiomyopathy.

Cardiol Young 2020 May 14;30(5):692-697. Epub 2020 Apr 14.

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Background: We evaluated a cohort of 35 children diagnosed with long QT syndrome, catecholaminergic polymorphic ventricular tachycardia, hypertrophic cardiomyopathy, or arrhythmogenic right ventricular cardiomyopathy with regard to physical and psychosocial well-being.

Material And Methods: Patients wore an accelerometer to record their time involved in moderate- to vigorous-intensity physical activity and completed the Pediatric Quality of Life Inventory and the Pediatric Cardiac Quality of Life Inventory. Parents were also asked to describe if their child had changed their physical activity because of their diagnosis and how difficult and upsetting it was for the child to adapt to the physical activity recommendations. Read More

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http://dx.doi.org/10.1017/S1047951120000803DOI Listing

Validity of administrative claims-based algorithms for ventricular arrhythmia and cardiac arrest in the pediatric population.

Pharmacoepidemiol Drug Saf 2020 Apr 13. Epub 2020 Apr 13.

Department of Pediatrics, Cardiology Section, School of Medicine, University of Colorado, Aurora, Colorado, USA.

Purpose: Identify administrative claims-based algorithms for capturing out-of-hospital ventricular arrhythmias (VA) and cardiac arrests (CA) due to cardiac causes in the pediatric population with high positive-predictive value (PPV).

Methods: Within a single pediatric center, a retrospective cohort of patients hospitalized or seen in the emergency room for VA or CA were identified from the electronic health records. Eligible encounters were blindly reviewed and linked to administrative data, including ICD-9/ICD-10 codes. Read More

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http://dx.doi.org/10.1002/pds.5001DOI Listing

Value of Exercise Stress Echocardiography in Children with Hypertrophic Cardiomyopathy.

J Am Soc Echocardiogr 2020 Apr 9. Epub 2020 Apr 9.

Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Division of Genetics, Boston Children's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address:

Background: Exercise stress echocardiography (ESE) is a valuable diagnostic and prognostic tool in adults with hypertrophic cardiomyopathy (HCM). Inducible and resting left ventricular outflow tract gradients are important predictors of heart failure. However, there are minimal data on the utility of this modality in children. Read More

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http://dx.doi.org/10.1016/j.echo.2020.01.020DOI Listing

Delayed-onset sinus node dysfunction in a child victim of Russell's viper bite.

Asian Cardiovasc Thorac Ann 2020 May 10;28(4):213-215. Epub 2020 Apr 10.

University Paediatrics Unit, Colombo North Teaching Hospital, Ragama, Sri Lanka.

Cardiac complications following envenomation by Russell's viper venom are uncommon. We describe a 14-year-old girl who developed delayed-onset sinus node dysfunction. She presented with mucosal bleeding, ptosis, and muscle weakness. Read More

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http://dx.doi.org/10.1177/0218492320919636DOI Listing

The timing of cognitive aid access during simulated pediatric intraoperative critical events.

Paediatr Anaesth 2020 Apr 9. Epub 2020 Apr 9.

Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois.

Background: Many cognitive aids are formatted in a step-by-step fashion with the intent that the aid will be accessed at the beginning of a critical event and that key behaviors will be performed in sequence.

Aims: We hypothesized that, during simulated pediatric intraoperative critical events, anesthesia clinicians may not use cognitive aids immediately after the onset of a critical event but instead access the aid only after first performing several key behaviors.

Materials And Methods: This manuscript is a re-analysis of previously published simulation data. Read More

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http://dx.doi.org/10.1111/pan.13868DOI Listing

Ventricular arrhythmia suppression with ivabradine in a patient with catecholaminergic polymorphic ventricular tachycardia refractory to nadolol, flecainide, and sympathectomy.

Pacing Clin Electrophysiol 2020 May 2;43(5):527-533. Epub 2020 May 2.

Center for Arrhythmia Care, Heart and Vascular Center, Pritzker School of Medicine of the University of Chicago, Chicago, Illinois.

Conventional treatment strategies for catecholaminergic polymorphic ventricular tachycardia (CPVT) include avoidance of strenuous exercise and competitive sports, drugs such as ß-blockers and flecainide and, cervical sympathectomy. An implantable cardioverter-defibrillator (ICD) has been utilized if the response to these strategies is inadequate; however, ICD use in CPVT patients, in addition to usual complications, is associated with an increased risk of life-threatening electrical storm. Ivabradine is a selective inhibitor of hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 generated funny current (I ), which has been shown to be efficacious in suppression of inappropriate sinus tachycardia, junctional tachycardia, atrial tachycardia, and ventricular ectopy in humans. Read More

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http://dx.doi.org/10.1111/pace.13913DOI Listing

Influence of age on clinical presentation, diagnosis delay and outcome in pre-school children with acute appendicitis.

BMC Pediatr 2020 Apr 6;20(1):151. Epub 2020 Apr 6.

Department of Pediatrics, University Hospital Liège, Liège, Belgium.

Background: Unusual clinical presentation of acute appendicitis in preschool children leads to misdiagnosis and complications. We aimed to analyze the influence of age on clinical presentation, laboratory findings and complications in preschool children with acute appendicitis.

Methods: From January 2012 until December 2017, 29 children younger than 6 years of age (median 50 months) with acute appendicitis were enrolled in this retrospective study. Read More

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http://dx.doi.org/10.1186/s12887-020-02053-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133018PMC

Abdominal Distention and Emesis in a Term Neonate.

J Emerg Med 2020 Mar 31. Epub 2020 Mar 31.

Department of Pediatric Emergency Medicine, Medical University of South Carolina, Charleston, South Carolina.

Background: Necrotizing enterocolitis (NEC) is a gastrointestinal emergency characterized by ischemic necrosis of the intestinal mucosa, leading to bacterial translocation and pneumatosis of the bowel wall. Although there are numerous studies on clinical presentations of preterm NEC, approximately 10-15% of cases occur in full-term neonates. Nearly 10% of all infants with NEC will develop a rapidly progressive and fatal form of the disease called NEC totalis. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.02.003DOI Listing

Case 2: A Term Neonate with Quiet Tachypnea Progressing to Tachycardia and Shock.

Neoreviews 2020 04;21(4):e267-e271

Department of Pediatrics, Armed Forces Medical College, Pune, India.

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http://dx.doi.org/10.1542/neo.21-4-e267DOI Listing

Ralstonia mannitolilytica, an unusual pathogen in the Neonatal Intensive Care Unit: a case of neonatal sepsis and literature review.

Infect Disord Drug Targets 2020 Mar 30. Epub 2020 Mar 30.

Department of Pediatrics and Neonatology, University General Hospital of Patras, Patras. Greece.

Background: Premature infants are considered high-risk subgroup for neonatal sepsis due to yet defective immune system, interventions practised and synergy of factors favoring multiple resistance of Gram-positive and Gram-negative pathogens to antimicrobial agents.

Case Presentation: We present a case of late-onset neonatal sepsis in a premature infant caused by an uncommon pathogen; a premature infant of extremely low birth weight had in his 4th week of life severe clinical deterioration with lethargy, fever, pallor, 1 mottling, abdominal distention, tachycardia, and worsening respiratory impairment. Full septic screen was performed, broad-spectrum antibiotic therapy was initiated and supportive care per needs was provided. Read More

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http://dx.doi.org/10.2174/1871526520666200330163504DOI Listing

SIDS associated RYR2 p.Arg2267His variant may lack pathogenicity.

J Electrocardiol 2020 Mar 18;60:23-26. Epub 2020 Mar 18.

Center for Arrhythmia Care, Heart & Vascular Center, Pritzker School of Medicine of the University of Chicago, Chicago, IL, United States of America.

Sudden infant death syndrome (SIDS) is the sudden death of an infant under 1 year of age that remains unexplained after death scene and medicolegal investigation, including a complete autopsy and clinical history review. The fatal event typically occurs during sleep and heart rhythm during the event is rarely documented. Large series which have utilized molecular autopsy show that long QT syndrome (LQTS) associated cardiac channel mutations contribute to between 5 and 10% of SIDS deaths. Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2020.03.007DOI Listing

Post-operative Brugada electrocardiographic pattern, polymorphic ventricular tachycardia, and sudden death in a child after administration of propofol anaesthesia.

Cardiol Young 2020 May 27;30(5):724-727. Epub 2020 Mar 27.

Department of Pediatrics, Division of Pediatric Cardiology, St. John Hospital Medical Center, Detroit, MI, USA.

A 9-year-old African-American girl presented with sudden cardiac arrest a few hours after adenotonsillectomy. She received anaesthesia which included propofol during the procedure. Her electrocardiogram (EKG) showed type 1 Brugada pattern, and genetic testing revealed a variant of unknown significance in desmoplakin (DSP) gene. Read More

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http://dx.doi.org/10.1017/S1047951120000578DOI Listing

Proceedings From the 2019 Stanford Single Ventricle Scientific Summit: Advancing Science for Single Ventricle Patients: From Discovery to Clinical Applications.

J Am Heart Assoc 2020 Apr 19;9(7):e015871. Epub 2020 Mar 19.

Department of Pediatrics (Cardiology) Stanford University Palo Alto CA.

Abstracts Because of remarkable advances in survival over the past 40 years, the worldwide population of individuals with single ventricle heart disease living with Fontan circulation has grown to ≈70 000, with nearly half aged >18 years. Survival to at least 30 years of age is now achievable for 75% of Fontan patients. On the other hand, single ventricle patients account for the largest group of the 6000 to 8000 children hospitalized with circulation failure, with or without heart failure annually in the United States, with the highest in-hospital mortality. Read More

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http://dx.doi.org/10.1161/JAHA.119.015871DOI Listing

Left Ventricular Noncompaction and Congenital Heart Disease Increases the Risk of Congestive Heart Failure.

J Clin Med 2020 Mar 13;9(3). Epub 2020 Mar 13.

Department of Pediatrics, International University of Health and Welfare, Tokyo 107-0052, Japan.

Background: Left ventricular noncompaction (LVNC) is a hereditary cardiomyopathy that is associated with high morbidity and mortality rates. Recently, LVNC was classified into several phenotypes including congenital heart disease (CHD). However, although LVNC and CHD are frequently observed, the role and clinical significance of genetics in these cardiomyopathies has not been fully evaluated. Read More

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http://dx.doi.org/10.3390/jcm9030785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141335PMC

Novel variants in TECRL cause recessive inherited CPVT type 3 with severe and variable clinical symptoms.

J Cardiovasc Electrophysiol 2020 Jun 22;31(6):1527-1535. Epub 2020 Mar 22.

Department of Molecular Genetics, MVZ Martinsried GmbH, Martinsried, Germany.

Introduction: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia syndrome characterized by adrenergically stimulated ventricular tachycardia. The most common form of CPVT is due to autosomal dominant variants in the cardiac ryanodine-receptor gene (RYR2). However, trans-2,3-enoyl-CoA reductase-like (TECRL) was recently suggested to be a novel candidate gene for life-threatening inherited arrhythmias. Read More

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http://dx.doi.org/10.1111/jce.14446DOI Listing

Clenbuterol: a new toxic substance in paediatrics.

BMJ Case Rep 2020 Mar 12;13(3). Epub 2020 Mar 12.

Emergency Department, Royal Hospital for Children, Glasgow, Scotland, UK.

A 13-year-old girl presented to the emergency department with acute onset of chest pain, nausea and tremor. The patient denied drug ingestion, and urine toxicology was negative. ECG demonstrated sinus tachycardia, prolonged QTc (541 ms) and ST depression. Read More

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http://dx.doi.org/10.1136/bcr-2019-233180DOI Listing

Institutional experience of healthy pediatric patients presenting with atrial fibrillation who had an electrophysiology study.

J Card Surg 2020 May 12;35(5):1004-1009. Epub 2020 Mar 12.

Division of Pediatric Cardiology, Saint Louis Children's Hospital, Washington University School of Medicine, Saint Louis, Missouri.

Introduction: Atrial fibrillation (AF) is a very common tachyarrhythmia with increasing prevalence with age, but uncommon in the pediatric population. Understanding that AF increases comorbidities make the need for investigation and potential elimination of alternate etiologies in pediatric AF patients critical. The objective of this study was to review our institutional data and compare our findings with previously documented adult AF risk factors to pediatric patients while also identifying which patients had alternate electrophysiology diagnoses amenable to transcatheter ablation. Read More

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http://dx.doi.org/10.1111/jocs.14506DOI Listing

Impact of dipyridamole on adenosine dosing in pediatric and young adult patients after heart transplantation.

Pediatr Transplant 2020 May 10;24(3):e13689. Epub 2020 Mar 10.

Division of Pediatric Cardiology, Columbia University Irving Medical Center, New York, NY, USA.

Background: Relative contraindications to adenosine use have included heart transplant and dipyridamole. We previously demonstrated the safety and efficacy of adenosine-induced atrioventricular (AV) block in healthy young heart transplant recipients while suspending dipyridamole therapy (dual antiplatelet agent). This prospective follow-up study evaluated the safety and efficacy of adenosine use in the same cohort of heart transplant recipients while on dipyridamole. Read More

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http://dx.doi.org/10.1111/petr.13689DOI Listing

Human papillomavirus vaccination and postural tachycardia syndrome, deconditioning and exercise-induced hyperalgesia: An alternate interpretation of the reported adverse reactions.

J Obstet Gynaecol Res 2020 May 9;46(5):678-683. Epub 2020 Mar 9.

Office of Medical Education, Center for Infectious Diseases, International University of Health and Welfare, Chiba, Japan.

Human papillomavirus vaccination (HPVV) was included in the national immunization program in 2013 in Japan. However, the Japanese government suspended proactive recommendations 2 months after this decision because various adverse events following the vaccination were reported by the media. More than 6 years have already passed since the suspension of proactive recommendations of all available vaccines in Japan. Read More

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http://dx.doi.org/10.1111/jog.14227DOI Listing