Brain Res 2022 05 26;1783:147849. Epub 2022 Feb 26.
Departments of Cell Biology & Anatomy, New York Medical College, Valhalla, NY 10595, United States; Departments of Pediatrics, New York Medical College, Valhalla, NY 10595, United States; Departments of Obstetrics & Gynecology, New York Medical College, Valhalla, NY 10595, United States.
Chronic subconvulsive activity in early life leads to sex-related autistic-like deficits in handling, object recognition, and social performance in pre-pubertal rats. Since autism and epilepsy are common neurodevelopmental disorders with high coincidence, we tested whether early-life chronic subconvulsive activity compared to convulsive activity alters handling, spatial memory, lateralization, coping strategy and the seizure threshold in a sex-dependent manner. A hypothesis is that convulsive seizures may alter sex differences induced by subconvulsive (SC) activity. Read More