200 results match your criteria Pediatrics Scarlet Fever

Identification of epidemic scarlet fever group A strains in the paediatric population of Houston, TX, USA.

Access Microbiol 2021 26;3(10):000274. Epub 2021 Oct 26.

Division of Infectious Diseases, Department of Pediatrics, McGovern Medical School at the University of Texas Health Sciences Center at Houston, Houston, Texas, USA.

Scarlet fever (SF) has recently been associated with group A streptococcal (GAS) strains possessing multidrug resistance and specific streptococcal exotoxins. We screened a local surveillance collection of GAS strains in Houston, TX, USA for antimicrobial resistance and identified a single isolate matching the antimicrobial resistance pattern previously reported for SF clones. Using whole-genome sequencing and combining genome sequence data derived from national surveillance databases, we identified additional GAS clones similar to those associated with prior SF outbreaks, emphasizing the need for continued surveillance for epidemic emergence in the USA. Read More

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October 2021

Incidence and Effects of Acquisition of the Phage-Encoded Superantigen Gene in Invasive Group A .

Front Microbiol 2021 4;12:685343. Epub 2021 Jun 4.

Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

The acquisition of the phage-encoded superantigen by scarlet fever-associated group A (, GAS) is found in North Asia. Nonetheless, the impact of acquiring by GAS in invasive infections is unclear. This study initially analyzed the prevalence of + GAS among isolates from sterile tissues and blood. Read More

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Thoughts, beliefs and concepts concerning infectious childhood diseases of physicians practicing homeopathic, anthroposophic and conventional medicine - a qualitative study.

BMC Complement Med Ther 2021 Jan 26;21(1):46. Epub 2021 Jan 26.

Institute for Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin, Luisenstr. 57, 10117, Berlin, Germany.

Background: Physicians who include complementary medicine in their practice are thought to have an understanding of health and disease different from that of colleagues practicing conventional medicine. The aim of this study was to identify and compare the thoughts and concepts concerning infectious childhood diseases (measles, mumps, rubella, chickenpox, pertussis and scarlet fever) of physicians practicing homeopathic, anthroposophic and conventional medicine.

Methods: This qualitative study used semistructured interviews. Read More

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January 2021

Impact of Nonpharmaceutical Interventions on the Incidence of Respiratory Infections During the Coronavirus Disease 2019 (COVID-19) Outbreak in Korea: A Nationwide Surveillance Study.

Clin Infect Dis 2021 04;72(7):e184-e191

Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background: Many countries have implemented nonpharmaceutical interventions (NPIs) to slow the spread of coronavirus disease 2019 (COVID-19). We aimed to determine whether NPIs led to the decline in the incidences of respiratory infections.

Methods: We conducted a retrospective, ecological study using a nationwide notifiable diseases database and a respiratory virus sample surveillance collected from January 2016 through July 2020 in the Republic of Korea. Read More

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Severe scarlet fever in a child with Down syndrome - a case report.

Germs 2020 Sep 1;10(3):260-265. Epub 2020 Sep 1.

PhD, Pediatrics Department No2, I. Horbachevsky Ternopil National Medical University, 1 Maydan Voli, Ternopil, 46001 Ukraine.

Introduction: Scarlet fever is an acute infectious disease that is characterized by development of characteristic pin-point exanthema in a patient with signs of streptococcal pharyngitis and tonsillitis. Nowadays, due to effective antibacterial treatment, severe complicated cases of scarlet fever are occasionally rare. Because of immunity particularities, patients with Down syndrome are predisposed to bacterial respiratory diseases (and scarlet fever among them), that usually have prolonged complicated course. Read More

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September 2020

Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes.

Nat Commun 2020 10 6;11(1):5018. Epub 2020 Oct 6.

Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, QLD, Australia.

The re-emergence of scarlet fever poses a new global public health threat. The capacity of North-East Asian serotype M12 (emm12) Streptococcus pyogenes (group A Streptococcus, GAS) to cause scarlet fever has been linked epidemiologically to the presence of novel prophages, including prophage ΦHKU.vir encoding the secreted superantigens SSA and SpeC and the DNase Spd1. Read More

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October 2020

Emergence of macrolide-resistant Streptococcus pyogenes emm12 in southern Taiwan from 2000 to 2019.

J Microbiol Immunol Infect 2021 Dec 12;54(6):1086-1093. Epub 2020 Sep 12.

Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City, Taiwan; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan City, Taiwan. Electronic address:

Background: Group A Streptococcus (GAS) is an important pathogen causing morbidity and mortality worldwide. Surveillance of resistance and emm type has important implication to provide helpful information on the changing GAS epidemiology and empirical treatment.

Methods: To study the emergence of resistant GAS in children with upper respiratory tract infection (URTI), a retrospective study was conducted from 2000 to 2019 in southern Taiwan. Read More

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December 2021

Epidemiological analysis of Group A Streptococcus infections in a hospital in Beijing, China.

Eur J Clin Microbiol Infect Dis 2020 Dec 16;39(12):2361-2371. Epub 2020 Jul 16.

Department of Dermatology, Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing, China.

Our study aimed to investigate the epidemiological and molecular characteristics of isolates collected from Group A Streptococcus (GAS) infections in children in Beijing China during the year 2019. Emm typing, superantigens, and erythromycin resistance genotypes were determined by PCR. Antimicrobial susceptibility testing was performed as recommended by Clinical Laboratory Standards Institute (CLSI). Read More

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December 2020

Molecular epidemiology and antimicrobial resistance of group a streptococcus recovered from patients in Beijing, China.

BMC Infect Dis 2020 Jul 13;20(1):507. Epub 2020 Jul 13.

Department of Dermatology, Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing, 100020, China.

Background: Group A streptococcus (GAS) is an important human pathogen responsible for a broad range of infections. Epidemiological surveillance has been crucial to detect changes in the geographical and temporal variation of the disease pattern. The objective of this study was to investigate the molecular epidemiological characteristics and antimicrobial resistance of GAS isolates from patients in Children's Hospital in Beijing. Read More

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Changes in M types of Streptococcus pyogenes in Chinese children with scarlet fever.

Lancet Infect Dis 2020 07;20(7):780

Shenzhen Children's Hospital, Shenzhen, China; Laboratory of Microbiology and Immunology, Beijing Children's Hospital affiliated to Capital Medical University, Beijing 100045, China. Electronic address:

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Paediatrics in Theresienstadt ghetto.

Cent Eur J Public Health 2020 Jun;28(2):155-160

Faculty of Education, Comenius University, Bratislava, Slovak Republic.

The main objective of this study is to describe the most common childhood diseases occurring in the Theresienstadt ghetto during the Second World War as well as applied anti-epidemic measures. A partial objective is to describe medical and nursing care of sick child prisoners. The data was obtained by the method of synthesis of primary and secondary data with the highest importance after adequate external source criticism using selected monographs, memoirs, survivor diaries, Orders of the day by the Council of the Elders and Reports of the Jewish self-government of the Theresienstadt ghetto from 1941 to 1945, the Archives of the Jewish Museum in Prague, the Ghetto Museum, the Museum of the History of Polish Jews in Warsaw, Post Bellum online electronic collection of oral historical interviews, and witness accounts. Read More

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Third human challenge trial conference, Oxford, United Kingdom, February 6-7, 2020, a meeting report.

Biologicals 2020 Jul 4;66:41-52. Epub 2020 Jun 4.

International Alliance for Biological Standardization, Belgium. Electronic address:

The third Human Challenge Trial Meeting brought together a broad range of international stakeholders, including academia, regulators, funders and industry, with a considerable delegation from Low- and Middle-Income Countries. Controlled human infection models (CHIMs) can be helpful to study pathogenesis and for the development of vaccines. As challenge agents are used to infect healthy volunteers, ethical considerations include that the challenge studies need to be safe and results should be meaningful. Read More

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Infectious diseases in children and adolescents in China: analysis of national surveillance data from 2008 to 2017.

BMJ 2020 04 2;369:m1043. Epub 2020 Apr 2.

Murdoch Children's Research Institute, Parkville, Victoria, Australia.

Objectives: To outline which infectious diseases in the pre-covid-19 era persist in children and adolescents in China and to describe recent trends and variations by age, sex, season, and province.

Design: National surveillance studies, 2008-17.

Setting: 31 provinces in mainland China. Read More

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Against the trend: a decrease in scarlet fever in New Zealand.

Lancet Infect Dis 2019 12;19(12):1285-1286

Department of Paediatrics, Starship Children's Hospital, The University of Auckland, Auckland 1010, New Zealand. Electronic address:

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December 2019

Long-term, single-center surveillance of non-invasive group A streptococcal (GAS) infections, emm types and emm clusters.

Eur J Clin Microbiol Infect Dis 2020 Feb 22;39(2):273-280. Epub 2019 Nov 22.

Department of Pediatrics, Carl Gustav Carus University Hospital, Technical University Dresden, Dresden, Germany.

Group A streptococci (GAS) are among the most frequent pathogens in children. Many epidemiological studies focus on specific GAS infections (such as tonsillopharyngitis or invasive disease), on GAS carriers or on post-streptococcal sequelae. By comparison, reports on regional GAS characteristics, particularly circulating non-invasive GAS in Europe, are rare. Read More

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February 2020

Severe Group A and Group B Streptococcus Diseases at a Pediatric ICU: Are they Still Sensitive to the Penicillins?

Curr Clin Pharmacol 2020 ;15(2):125-131

Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

Background: Group A β-hemolytic Streptococcus (GAS) and Group B streptococcus (GBS) are two common pathogens that are associated with many diseases in children. Severe infections as a result of these two streptococci are albeit uncommon but associated with high mortality and morbidity, and often necessitate intensive care support. This paper aims to review the mortality and morbidity of severe infection associated with GAS and GBS isolations at a Pediatric Intensive Care Unit (PICU). Read More

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September 2021

Acute rheumatic fever diagnosis and management: Review of the global implications of the new revised diagnostic criteria with a focus on Saudi Arabia.

J Saudi Heart Assoc 2019 Oct 13;31(4):273-281. Epub 2019 Aug 13.

Department of Cardiology, Prince Sultan Cardiac Center, Riyadh, Saudi ArabiaSaudi Arabia.

Rheumatic fever (RF) is a common cause of acquired heart disease in children worldwide. It is a delayed, nonsuppurative, autoimmune phenomenon following pharyngitis, impetigo, or scarlet fever caused by group A β-hemolytic streptococcal (GAS) infection. RF diagnosis is clinical and based on revised Jones criteria. Read More

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October 2019

Detection of Epidemic Scarlet Fever Group A Streptococcus in Australia.

Clin Infect Dis 2019 09;69(7):1232-1234

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, Australia.

Sentinel hospital surveillance was instituted in Australia to detect the presence of pandemic group A Streptococcus strains causing scarlet fever. Genomic and phylogenetic analyses indicated the presence of an Australian GAS emm12 scarlet fever isolate related to United Kingdom outbreak strains. National surveillance to monitor this pandemic is recommended. Read More

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September 2019

Determinants of inter-practice variation in childhood asthma and respiratory infections: cross-sectional study of a national sentinel network.

BMJ Open 2019 01 24;9(1):e024372. Epub 2019 Jan 24.

Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK.

Objectives: Respiratory infections are associated with acute exacerbations of asthma and accompanying morbidity and mortality. In this study we explore inter-practice variations in respiratory infections in children with asthma and study the effect of practice-level factors on these variations.

Design: Cross-sectional study. Read More

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January 2019

Scarlet fever associated with hepatitis in pediatrics. A case report.

Rev Chil Pediatr 2018 Aug;89(4):521-524

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Miller School of Medicine, University of Miami, USA.

Introduction: Scarlet fever is a common illness in pediatrics caused by group A beta-hemolytic strep tococcus (GABHS), which usually occurs after an episode of pharyngitis, and has an overall excellent prognosis. Hepatitis secondary to scarlet fever is a rare complication described in adults and even less frequently in children. Our objective was to describe a case of hepatitis secondary to scarlet fever in a pediatric patient. Read More

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Group A Streptococcus disease in Hong Kong children: an overview.

Hong Kong Med J 2018 Dec 9;24(6):593-601. Epub 2018 Nov 9.

Department of Paediatrics, Alberta Children's Hospital, The University of Calgary, Calgary, Alberta, Canada.

Group A β-haemolytic or is a gram-positive coccus that tends to grow in chains. is the cause of many important human diseases, ranging from pharyngitis and mild superficial skin infections to life-threatening systemic diseases. Infections typically begin in the throat or skin. Read More

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December 2018

A 12 year outbreak of scarlet fever in Singapore.

Lancet Infect Dis 2018 09;18(9):942

Infectious Disease Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore 229899.

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September 2018

Into Darkness and Silence: What Caused Helen Keller's Deafblindness?

Janet R Gilsdorf

Clin Infect Dis 2018 10;67(9):1445-1449

Department of Pediatrics, University of Michigan Medical School, Ann Arbor.

In 1882, at 19 months of age, Helen Keller developed a febrile illness that left her both deaf and blind. Historical biographies attribute the illness to rubella, scarlet fever, encephalitis, or meningitis. This analysis of her illness suggests she likely had bacterial meningitis, caused by Neisseria meningitidis or possibly Haemophilus influenzae. Read More

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October 2018

Lichen striatus following scarlet fever in a 3-year-old female patient.

Int J Dermatol 2018 09 14;57(9):1118-1119. Epub 2018 Apr 14.

Department of Dermatology, Hospital Sant Joan de Déu, Barcelona, Spain.

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September 2018

Outbreak Investigation of Scarlet Fever in a Kindergarten.

Hyunju Lee

Infect Chemother 2018 03;50(1):65-66

Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongam, Korea.

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Identification and Characterization of Fluoroquinolone Non-susceptible Clones Harboring Tetracycline and Macrolide Resistance in Shanghai, China.

Front Microbiol 2018 23;9:542. Epub 2018 Mar 23.

Department of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.

, also known as group A (GAS), is one of the top 10 infectious causes of death worldwide. Macrolide and tetracycline resistant GAS has emerged as a major health concern in China coinciding with an ongoing scarlet fever epidemic. Furthermore, increasing rates of fluoroquinolone (FQ) non-susceptibility within GAS from geographical regions outside of China has also been reported. Read More

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Staphylococcal Scalded Skin Syndrome in Child. A Case Report and a Review from Literature.

J Crit Care Med (Targu Mures) 2016 Oct 8;2(4):192-197. Epub 2016 Nov 8.

Infectious Diseases Department, University of Medicine and Pharmacy Târgu-Mureș, Târgu-Mureș, Romania.

Staphylococcal scalded skin syndrome (SSSS) is the medical term used to define a skin condition induced by the exfoliative toxins produced by Staphylococcus aureus. The disorder is also known as Ritter disease, bullous impetigo, neonatal pemphigus, or staphylococcal scarlet fever. The disease especially affects infants and small children, but has also been described in adults. Read More

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October 2016

Re-emergence of scarlet fever: old players return?

Expert Rev Anti Infect Ther 2016 08 13;14(8):687-9. Epub 2016 Jun 13.

b Pediatric Infectious Diseases Unit, Department of Pediatrics , Geneva University Hospitals & University of Geneva Medical School , Geneva , Switzerland.

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The Role of Childhood Infections and Immunizations on Childhood Rhabdomyosarcoma: A Report From the Children's Oncology Group.

Pediatr Blood Cancer 2016 09 19;63(9):1557-62. Epub 2016 May 19.

Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas.

Background: Rhabdomyosarcoma (RMS) is a rare, highly malignant tumor arising from primitive mesenchymal cells that differentiate into skeletal muscle. Relatively little is known about RMS susceptibility. Based on growing evidence regarding the role of early immunologic challenges on RMS development, we evaluated the role of infections and immunizations on this clinically significant pediatric malignancy. Read More

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September 2016