1,022 results match your criteria Pediatrics Rubella


Rubella (German measles) revisited.

Hong Kong Med J 2019 Apr 10;25(2):134-141. Epub 2019 Apr 10.

Department of Pediatric Institute, Kuala Lumpur General Hospital, Malaysia.

Rubella is generally a mild and self-limited disease in children. During pregnancy, rubella can have potentially devastating effects on the developing fetus. Postnatal rubella is transmitted primarily by inhalation of virus-laden airborne droplets or direct contact with infected nasopharyngeal secretions. Read More

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http://dx.doi.org/10.12809/hkmj187785DOI Listing
April 2019
1 Read

Diagnosis of congenital/perinatal infections by neonatologists: a national survey.

J Perinatol 2019 Mar 26. Epub 2019 Mar 26.

Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.

Objective: To describe the clinical approach used by neonatologists for diagnosis of congenital/perinatal infections (CPI); no such data currently exist.

Study Design: A national survey regarding the diagnosis of toxoplasma, syphilis, rubella, cytomegalovirus, and herpes simplex virus (HSV) infection in neonates.

Result: We received 553 (11%) responses. Read More

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http://dx.doi.org/10.1038/s41372-019-0364-3DOI Listing
March 2019
1 Read

Rate of Recurrence of Adverse Events Following Immunization: Results of 19 Years of Surveillance In Quebec, Canada.

Pediatr Infect Dis J 2019 Apr;38(4):377-383

From the Department of Social and Preventive Medicine, Laval University, Quebec, Canada.

Background: While adverse events following immunization (AEFI) are frequent, there are limited data on the safety of reimmunizing patients who had a prior AEFI. Our objective was to estimate the rate and severity of AEFI recurrences.

Methods: We analyzed data from the AEFI passive surveillance system in Quebec, Canada, that collects information on reimmunization of patients who had a prior AEFI. Read More

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http://dx.doi.org/10.1097/INF.0000000000002162DOI Listing
April 2019
3 Reads

Aniridia: A Rare Manifestation Of Congenital Rubella Syndrome.

J Ayub Med Coll Abbottabad 2019 Jan-Mar;31(1):131-133

Ayub Medical College Abbottabad, Pakistan.

A foetus affected by a congenital rubella infection can develop congenital rubella syndrome (CRS). Aniridia is the absence of iris, rarely been described in literature in association with CRS, can easily be overlooked, leading to complications e.g. Read More

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March 2019
4 Reads

Congenital B-cell Acute Lymphoblastic Leukemia with Congenital Rubella Infection.

Indian Pediatr 2019 Jan;56(1):67-68

Department of Pathology, Sir Padampat Mother and Child Health Institute, JK Lon Hospital, SMS Medical College, Jaipur, Rajasthan, India.

Background: Congenital B-cell Acute lymphoblastic leukemia (ALL) is a rare malignancy.

Characteristics: A newborn infant presented with purpuric spots and ecchymotic patches, blueberry muffin rash, depressed neonatal reflexes, respiratory distress and hepatosplenomegaly. Peripheral smear revealed atypical blast cells. Read More

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January 2019
1 Read

The immunomodulatory effects of measles-mumps-rubella vaccination on persistence of heterologous vaccine responses.

Immunol Cell Biol 2019 Feb 21. Epub 2019 Feb 21.

Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.

It is proposed that measles-containing vaccines have immunomodulatory effects which include a reduction in all-cause childhood mortality. The antibody response to heterologous vaccines provides a means to explore these immunomodulatory effects. This is the first study to investigate the influence of measles-mumps-rubella (MMR) vaccine on the persistence of antibodies to a broad range of heterologous infant vaccinations given in the first year of life. Read More

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http://dx.doi.org/10.1111/imcb.12246DOI Listing
February 2019
5 Reads

Protection against varicella with two doses of combined measles-mumps-rubella-varicella vaccine or one dose of monovalent varicella vaccine: 10-year follow-up of a phase 3 multicentre, observer-blind, randomised, controlled trial.

Lancet Infect Dis 2019 Mar 11;19(3):287-297. Epub 2019 Feb 11.

University of Defence, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic; Charles University, Faculty of Medicine in Hradec Kralove, Department of Social Medicine, Hradec Kralove, Czech Republic.

Background: The duration of protection provided by varicella vaccines is unclear. We assessed the 10-year vaccine efficacy of two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV), one live attenuated varicella vaccine (V) dose given after one measles-mumps-rubella vaccine (MMR) dose (MMR + V), versus two MMR doses (control vaccine) for the prevention of confirmed varicella.

Methods: This was a phase 3b follow-up of an observer-blinded, randomised, controlled trial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14733099183071
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http://dx.doi.org/10.1016/S1473-3099(18)30716-3DOI Listing
March 2019
7 Reads

Early disappearance of maternal anti-measles, mumps, rubella, and varicella antibodies in Indian infants.

Vaccine 2019 Mar 11;37(11):1443-1448. Epub 2019 Feb 11.

Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed To Be University), Pune, India. Electronic address:

Background: Immunization of children with vaccines against Measles, Mumps, Rubella, and Varicella (MMRV) is practiced globally with varied recommendations. In India, measles vaccine is administered alone or as MMR at 9 months age. Varicella vaccine is not routinely used. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193011
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http://dx.doi.org/10.1016/j.vaccine.2019.01.043DOI Listing
March 2019
16 Reads

Vaccination Against Measles, Mumps, and Rubella in the Light of Current Epidemic Threats: Unjustified Postponement.

Adv Exp Med Biol 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatrics with Clinical Assessment Unit, Warsaw Medical University, Warsaw, Poland.

A worrying increase in the number of measles cases has been noted recently in Poland, which may have to do with a decreasing proportion of children vaccinated against measles, mumps, and rubella (MMR) in the second year of life (<95%). For many years, MMR vaccination in children has been associated with a fear of allergy to eggs. This study seeks to define the reason and justification for postponing MMR vaccination in a population of children referred to the outpatient specialist immunization clinic. Read More

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http://dx.doi.org/10.1007/5584_2019_344DOI Listing
February 2019
2 Reads

50 Years Ago in The Journal of Pediatrics: Maternal and Congenital Rubella before 1964: Frequency, Clinical Features, and Search for Isoimmune Phenomena.

J Pediatr 2019 Feb;205:82

Department of Pediatrics University College of Medical Sciences Delhi, India.

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http://dx.doi.org/10.1016/j.jpeds.2018.08.045DOI Listing
February 2019
4 Reads

Outcomes for Nitazoxanide Treatment in a Case Series of Patients with Primary Immunodeficiencies and Rubella Virus-Associated Granuloma.

J Clin Immunol 2019 Jan 24;39(1):112-117. Epub 2019 Jan 24.

Division of Allergy Immunology, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, 3615 Civic Center Blvd, Philadelphia, PA, 19104, USA.

Purpose: Nitazoxanide was recently reported as having in vitro effectiveness against the rubella virus. Immunodeficiency-related vaccine-derived rubella occurs in some patients who have an inherited immunodeficiency and who received the MMR vaccine. This study investigated the in vivo effectiveness of nitazoxanide therapy. Read More

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http://dx.doi.org/10.1007/s10875-019-0589-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383808PMC
January 2019
5 Reads

Complications and risk factors for severe outcome in children with measles.

Arch Dis Child 2019 Jan 12. Epub 2019 Jan 12.

Pediatric Infectious Diseases Unit, Anna Meyer Children's University Hospital, Florence, Italy.

Objective And Design: Risk factors for severe measles are poorly investigated in high-income countries. The Italian Society for Paediatric Infectious Diseases conducted a retrospective study in children hospitalised for measles from January 2016 to August 2017 to investigate the risk factors for severe outcome defined by the presence of long-lasting sequelae, need of intensive care or death.

Results: Nineteen hospitals enrolled 249 children (median age 14. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315290DOI Listing
January 2019
3 Reads

Rubella Virus-Associated Cutaneous Granulomatous Disease: a Unique Complication in Immune-Deficient Patients, Not Limited to DNA Repair Disorders.

J Clin Immunol 2019 Jan 3;39(1):81-89. Epub 2019 Jan 3.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Department of Pediatrics, University of Washington, Seattle, WA, USA.

The association of immunodeficiency-related vaccine-derived rubella virus (iVDRV) with cutaneous and visceral granulomatous disease has been reported in patients with primary immunodeficiency disorders (PIDs). The majority of these PID patients with rubella-positive granulomas had DNA repair disorders. To support this line of inquiry, we provide additional descriptive data on seven previously reported patients with Nijmegen breakage syndrome (NBS) (n = 3) and ataxia telangiectasia (AT) (n = 4) as well as eight previously unreported patients with iVDRV-induced cutaneous granulomas and DNA repair disorders including NBS (n = 1), AT (n = 5), DNA ligase 4 deficiency (n = 1), and Artemis deficiency (n = 1). Read More

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http://link.springer.com/10.1007/s10875-018-0581-0
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http://dx.doi.org/10.1007/s10875-018-0581-0DOI Listing
January 2019
17 Reads

Serologic Status of Routine Childhood Vaccines, Cytomegalovirus, and Epstein-Barr Virus in Children With Inflammatory Bowel Disease.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

Section of Paediatric Gastroenterology, Department of Paediatrics, University of Calgary, Calgary, Alberta, Canada.

Background: Data on the serologic status of childhood vaccines, cytomegalovirus (CMV) and Epstein-Barr virus (EBV), are limited in inflammatory bowel disease (IBD). Therefore, we evaluated vaccine coverage and seroprotection, along with CMV and EBV seropositivity, in pediatric IBD.

Methods: In a cross-sectional study, demographic data, IBD history, vaccine records, and serum for antibodies against measles, mumps, rubella, diphtheria, tetanus, varicella, hepatitis B (HBV), CMV, and EBV were collected from children with IBD. Read More

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http://dx.doi.org/10.1093/ibd/izy366DOI Listing
December 2018
9 Reads

Clinical manifestations of congenital rubella syndrome: A review of our experience in Vietnam.

Vaccine 2019 Jan 30;37(1):202-209. Epub 2018 Nov 30.

Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan. Electronic address:

Rubella vaccination programs have dramatically reduced the incidence of rubella and congenital rubella syndrome (CRS) in developed countries. However, CRS prevalence is still rising in developing countries where rubella-containing vaccines (RCV) are not included in the immunization program and even in some countries where a part of the population lacks immunity to rubella despite the presence of RCV in the regular immunization program. This review aimed to summarize the clinical features of CRS using data from our studies conducted between 2011 and 2015 in Vietnam, wherein we examined clinical manifestations in Vietnamese children with CRS who were born after the large rubella outbreak of 2011; a series of studies dealing with CRS in North America and Europe after the 1960s epidemic; and those from countries before introduction of RCVs. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.11.046DOI Listing
January 2019
3 Reads

Retrospective evaluation of children with immune thrombocytopenic purpura and factors contributing to chronicity.

Pediatr Neonatol 2018 Nov 3. Epub 2018 Nov 3.

University of Health Sciences, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital, Department of Hematology, Ankara, Turkey.

Objective: Immune thrombocytopenic purpura (ITP) is the most common cause of acquired thrombocytopenia children. The aim of this retrospective study is to describe presenting features and clinical characteristics of ITP and evaluate clinical course, treatment modalities, and complications and determine the effects of preceding infection history, age, gender, treatment modality, and admission platelet count on chronicity.

Method: Two hundred and eleven patients who were diagnosed ITP and followed-up in Department of Pediatric Hematology, Ankara Children Hematology Oncology Education and Research Hospital between January 2008 and September 2012 were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18759572173061
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http://dx.doi.org/10.1016/j.pedneo.2018.10.002DOI Listing
November 2018
18 Reads
0.880 Impact Factor

Hospital based surveillance of congenital rubella syndrome cases in the pre-vaccine era in Amhara Regional State, Ethiopia: A base line information for the country.

PLoS One 2018 12;13(11):e0207095. Epub 2018 Nov 12.

Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Rubella virus infection in early pregnancy lead to serious multi-organ birth defects known as congenital rubella syndrome (CRS). The incidence of CRS varies in different populations and the highest burden is found in developing countries in which rubella vaccination is not included in their national immunization programs. In Ethiopia, there is scarcity of data about congenital rubella syndrome. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207095PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231648PMC

Implementing Universal Varicella Vaccination in Europe: The Path Forward.

Pediatr Infect Dis J 2019 Feb;38(2):181-188

University of Tampere Medical School, Tampere, Finland.

Varicella is a common vaccine-preventable disease that usually presents as a mild disorder but can lead to severe complications. Before the implementation of universal varicella vaccination (UVV) in some European countries, the burden of varicella disease was broadly similar across the region. Despite this, countries adopted heterogeneous varicella vaccination strategies. Read More

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http://dx.doi.org/10.1097/INF.0000000000002233DOI Listing
February 2019
5 Reads

Measles and Rubella Seroprevalence in Mother-Infant Pairs in Rural Nepal and the United States: Pre- and Post-Elimination Populations.

Am J Trop Med Hyg 2018 Nov;99(5):1342-1345

Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington.

We sought to compare seroprevalence of protective measles and rubella-specific antibody in mother-infant pairs across two populations: a pre-disease elimination Nepal population with recently introduced rubella vaccine and post-disease elimination U.S. population. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.17-0836
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http://dx.doi.org/10.4269/ajtmh.17-0836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221218PMC
November 2018
15 Reads
2.699 Impact Factor

Immunisation status of children with cerebral palsy in rural Bangladesh: results from the Bangladesh Cerebral Palsy Register (BCPR).

Infect Disord Drug Targets 2018 Oct 23. Epub 2018 Oct 23.

Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Sydney. Australia.

Background: Cerebral palsy (CP) is the most common cause of physical disability in childhood, with an estimated 17 million cases worldwide. There is limited data concerning the general health of this population and the immunisation status of children with CP is largely unknown.

Objective: We aimed to assess the immunisation status of children with CP in rural Bangladesh and determine the predictors of non-immunisation. Read More

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http://dx.doi.org/10.2174/1871526518666181024101002DOI Listing
October 2018
10 Reads

Hong Kong Institute of Allergy and Hong Kong Society for Paediatric Immunology Allergy & Infectious Diseases joint consensus statement 2018 on vaccination in egg-allergic patients.

Hong Kong Med J 2018 Oct;24(5):527-531

Allergy Centre, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong.

Vaccination of egg-allergic individuals has been a historical concern, particularly for influenza and measles-mumps-rubella-varicella vaccines that are developed in chicken egg embryos or chicken cell fibroblasts. The egg proteins in these vaccines were believed to trigger an immediate allergic reaction in egg-allergic individuals. However, recently published international guidelines have updated their recommendations and now state that these vaccines can be safely administered to egg-allergic individuals. Read More

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http://dx.doi.org/10.12809/hkmj177137DOI Listing
October 2018
9 Reads

Measles: a disease often forgotten but not gone.

Hong Kong Med J 2018 Oct;24(5):512-520

Department of Pediatrics and Department of Laboratory Medicine and Pathology, The University of Alberta, Edmonton, Alberta, Canada.

Measles (rubeola) is a highly contagious vaccine-preventable disease caused by the measles virus-a virus of the family. The illness typically begins with fever, runny nose, cough, and pathognomonic enanthem (Koplik spots) followed by a characteristic erythematous, maculopapular rash. The rash classically begins on the face and becomes more confluent as it spreads cephalocaudally. Read More

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http://dx.doi.org/10.12809/hkmj187470DOI Listing
October 2018
8 Reads

Clinical epidemiology of congenital heart disease in Nigerian children, 2012-2017.

Birth Defects Res 2018 10 19;110(16):1233-1240. Epub 2018 Sep 19.

Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.

Background: Congenital heart diseases (CHDs) affect ~1% of newborns and are a significant cause of morbidity and mortality in children. We present the clinical epidemiology of CHD as seen in a large university medical center in Nigeria.

Methods: Participants were 767 children with echocardiographically confirmed CHD seen over a 5-year period at the Lagos University Teaching Hospital, Nigeria. Read More

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http://dx.doi.org/10.1002/bdr2.1361DOI Listing
October 2018
3 Reads

Congenital rubella syndrome surveillance in South Africa using a sentinel site approach: a cross-sectional study.

Clin Infect Dis 2018 Sep 8. Epub 2018 Sep 8.

National Institute for Communicable Diseases, A division of the National Health Laboratory Service, South Africa.

Background: Congenital rubella syndrome (CRS) includes disorders associated with intrauterine rubella infection. Incidence of CRS is higher in countries with no rubella-containing vaccines (RCV) in their immunization schedules. In the World Health Organization African region, RCVs are being introduced as part of the 2012-2020 global measles and rubella strategic plan. Read More

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http://dx.doi.org/10.1093/cid/ciy758DOI Listing
September 2018
20 Reads

Measles outbreak in a French Roma community in the Provence-Alpes-Côte d'Azur region, France, May to July 2017.

Int J Infect Dis 2018 11 7;76:97-101. Epub 2018 Sep 7.

Aix-Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France;

Objectives: To analyse a measles outbreak in a Roma community.

Methods: We describe a community-wide outbreak of genotype D8 measles that took place in southeastern France, between May and July 2017, along with the control measures adopted.

Results: We identified a total of eighteen cases, between six months and 24 years old. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.08.023DOI Listing
November 2018
12 Reads

Multimodal safety assessment of measles-mumps-rubella vaccination after pediatric liver transplantation.

Am J Transplant 2019 Mar 1;19(3):844-854. Epub 2018 Oct 1.

Department of Pediatrics, Division of General Pediatrics, Children's Hospital, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

Live-attenuated vaccines are currently contraindicated in solid-organ transplant recipients. However, the risk of vaccine-preventable infections is lifelong, and can be particularly severe after transplantation. In this prospective interventional national cohort study, 44 pediatric liver transplant recipients with measles IgG antibodies <150 IU/L (below seroprotection threshold) received measles-mumps-rubella vaccine (MMR) at a median of 6. Read More

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http://dx.doi.org/10.1111/ajt.15101DOI Listing
March 2019
7 Reads

Dominant SCN2A Mutation Causes Familial Episodic Ataxia and Impairment of Speech Development.

Neuropediatrics 2018 Dec 30;49(6):379-384. Epub 2018 Aug 30.

Division of Pediatric Neurology, Department of Pediatrics, University Hospital Cologne, Cologne, Germany.

Mutations in are associated with a heterogeneous clinical spectrum including epilepsy and autism. Here, we have identified a peculiar phenotype associated with vaccination related exacerbations of ataxia. We report the first family with three individuals affected by -associated episodic ataxia (EA) with impaired speech development. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1668141
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http://dx.doi.org/10.1055/s-0038-1668141DOI Listing
December 2018
23 Reads

Seroprevalence of Maternal and Cord Antibodies Specific for Diphtheria, Tetanus, Pertussis, Measles, Mumps and Rubella in Shunyi, Beijing.

Sci Rep 2018 Aug 29;8(1):13021. Epub 2018 Aug 29.

Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Maternal antibodies contribute to the protection of young infants from infectious diseases during the early life. However, vaccinations for women of child-bearing age are not routine in China. Therefore, we investigated the level of protective immunity against vaccine preventable diseases in pregnant women and newborns in China. Read More

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http://dx.doi.org/10.1038/s41598-018-31283-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115429PMC
August 2018
8 Reads
5.080 Impact Factor

[Prevalence of maternal measles, rubella, mumps and varicella antibodies in the first six months of life].

Mikrobiyol Bul 2018 Jul;52(3):324-327

Istanbul University Faculty of Medicine, Department of Medical Microbiology, Division of Virology and Basic Immunology, Istanbul, Turkey.

The protection of infants against infections during the first few months of life is provided mainly by maternal antibodies. The presence of maternal antibodies can decrease vaccine efficacy. The waning time of maternal antibodies shows variations therefore seroepidemiological studies are important for the development of vaccination schedules. Read More

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http://www.mikrobiyolbul.org/linkout.aspx?pmid=30156519
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http://dx.doi.org/10.5578/mb.67169DOI Listing
July 2018
23 Reads

Persistent detection of Zika virus RNA from an infant with severe microcephaly - a case report.

BMC Infect Dis 2018 Aug 10;18(1):388. Epub 2018 Aug 10.

Department of Virology and Experimental Therapy, Aggeu Magalhães Institute, Oswaldo Cruz Foundation - FIOCRUZ, Avenida Professor Moraes Rego s/n, Recife, PE, 50740-465, Brazil.

Background: Zika virus (ZIKV) is a recently emerged arbovirus, which infection during pregnancy is associated with a series of congenital malformations, collectively denominated Congenital Zika Syndrome (CZS). Following infection, ZIKV RNA has a median duration period of 10 days in plasma and up to 6 months in semen in immunocompetent adult individuals. Moreover, ZIKV is able to replicate and persist in fetal brains and placentas, consequently, infection is associated with pregnancy loss, albeit the pathogenic mechanisms are still unknown. Read More

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http://dx.doi.org/10.1186/s12879-018-3313-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086026PMC
August 2018
6 Reads

Recurrent invasive group A streptococcal infection with four-limb amputation in an immunocompetent child.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.

We report a previously well paediatric patient with two distinct presentations of invasive group A streptococcus (GAS) infection resulting in significant morbidity. The first episode, following GAS pharyngitis, involved multiorgan dysfunction syndrome. This included cardiorespiratory and acute hepatorenal failure and purpura fulminans that eventually necessitated four-limb amputation. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22529
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http://dx.doi.org/10.1136/bcr-2018-225292DOI Listing
July 2018
10 Reads

Pediatricians' vaccine attitudes and practices before and after a major measles outbreak.

J Child Health Care 2018 Jan 1:1367493518786011. Epub 2018 Jan 1.

3 Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA.

The objective of this study was to describe how a sample of pediatricians were impacted by and responded to the Disneyland measles outbreak in the United States. We conducted three repeated cross-sectional, online surveys in 2014 (before the outbreak), 2015, and 2016 (after the outbreak) among members of three state chapters of the American Academy of Pediatrics. We assessed pediatricians' level of willingness and length of time comfortable delaying the measles-mumps-rubella (MMR) vaccine before and after the outbreak. Read More

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http://dx.doi.org/10.1177/1367493518786011DOI Listing
January 2018
7 Reads

Immunization Mandates, Vaccination Coverage, and Exemption Rates in the United States.

Open Forum Infect Dis 2018 Jun 2;5(6):ofy130. Epub 2018 Jun 2.

Department of Family Medicine, SUNY Upstate Medical University, Syracuse, New York.

Background: Vaccination coverage among children entering kindergarten in the United States is high, but interstate variations exist. The relationship between state immunization laws and vaccination coverage has not been fully assessed. We evaluated associations of state laws on both measles, mumps, and rubella (MMR) and diphtheria, tetanus, and pertussis (DTaP) vaccination coverage and exemptions to school immunization requirements. Read More

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http://dx.doi.org/10.1093/ofid/ofy130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016709PMC
June 2018
39 Reads

Measles in healthcare workers during the ongoing epidemic in Greece, 2017-2018.

J Hosp Infect 2018 Dec 11;100(4):e261-e263. Epub 2018 Jun 11.

Department of Epidemiologic Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece.

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http://dx.doi.org/10.1016/j.jhin.2018.06.007DOI Listing
December 2018
6 Reads

Mandatory vaccinations in European countries, undocumented information, false news and the impact on vaccination uptake: the position of the Italian pediatric society.

Ital J Pediatr 2018 Jun 14;44(1):67. Epub 2018 Jun 14.

Bambino Gesù Children Hospital, Pediatric and Infectious Diseases Unit, Rome, Italy.

Background: High rates of vaccination coverage are important in preventing infectious diseases. Enforcing mandatory vaccinations is one of the strategies that some Countries adopted to protect the community when vaccination coverage is not satisfactory. In Italy, in 2017 vaccination against diphtheria, tetanus, pertussis, hepatitis B, poliovirus, Haemophilus influenzae type b, measles, mumps, rubella and varicella became compulsory in childhood. Read More

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http://dx.doi.org/10.1186/s13052-018-0504-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001041PMC
June 2018
8 Reads

Vaccine-preventable diseases, vaccines and Guillain-Barre' syndrome.

Vaccine 2018 Jun 4. Epub 2018 Jun 4.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Perugia, Italy. Electronic address:

Guillain-Barré syndrome (GBS) is an acute, immune-mediated polyradiculoneuropathy. Infections and vaccines have been hypothesized to play a role in triggering GBS development. These beliefs can play a role in reducing vaccination coverage. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.05.119DOI Listing
June 2018
5 Reads

Update From the Advisory Committee on Immunization Practices.

J Pediatric Infect Dis Soc 2018 May;7(2):93-99

Stanford University School of Medicine, California.

The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, each of whom is appointed to a 4-year term. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Read More

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http://dx.doi.org/10.1093/jpids/piy028DOI Listing
May 2018
8 Reads

Into Darkness and Silence: What Caused Helen Keller's Deafblindness?

Authors:
Janet R Gilsdorf

Clin Infect Dis 2018 Oct;67(9):1445-1449

Department of Pediatrics, University of Michigan Medical School, Ann Arbor.

In 1882, at 19 months of age, Helen Keller developed a febrile illness that left her both deaf and blind. Historical biographies attribute the illness to rubella, scarlet fever, encephalitis, or meningitis. This analysis of her illness suggests she likely had bacterial meningitis, caused by Neisseria meningitidis or possibly Haemophilus influenzae. Read More

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http://dx.doi.org/10.1093/cid/ciy385DOI Listing
October 2018
11 Reads

Decreased antibodies against rubella in previously vaccinated treatment-naïve childhood systemic lupus erythematous patients: a prospective case-control study.

Scand J Rheumatol 2019 01 9;48(1):74-76. Epub 2018 May 9.

a Rheumatology and Infectious Diseases Unit, Second Department of Pediatrics, 'P and A Kyriakou' Children's Hospital, Medical School , National and Kapodestrian University of Athens , Athens , Greece.

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http://dx.doi.org/10.1080/03009742.2018.1446100DOI Listing
January 2019
2 Reads

TORCH (toxoplasmosis, rubella, cytomegalovirus, and herpes simplex virus) screening of small for gestational age and intrauterine growth restricted neonates: efficacy study in a single institute in Korea.

Korean J Pediatr 2018 Apr 23;61(4):114-120. Epub 2018 Apr 23.

Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Routine screening for toxoplasmosis, rubella, cytomegalovirus (CMV), and herpes simplex virus (TORCH) in intrauterine growth restriction (IUGR) and small for gestational age (SGA) neonates has become a common practice. However, the incidence of TORCH varies across countries, and the cost of TORCH testing may be disadvantageous compared to disease-specific screening. To evaluate the efficacy of TORCH screening, the medical charts of IUGR or SGA neonates born in a single institution in Bucheon, Korea from 2011 to 2015 were reviewed. Read More

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http://kjp.or.kr/journal/view.php?doi=10.3345/kjp.2018.61.4.
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http://dx.doi.org/10.3345/kjp.2018.61.4.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924842PMC
April 2018
25 Reads

Adherence and immune response to revaccination following hematopoietic stem cell transplantation at a pediatric onco-hematology reference center.

Transpl Infect Dis 2018 Aug 7;20(4):e12903. Epub 2018 May 7.

Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.

Background: Revaccination after hematopoietic stem cell transplantation (HSCT) is necessary to compensate for the loss of immunological memory. The aims of this study were to evaluate the adherence to revaccination schedule and the humoral immune response to different vaccine antigens in HSCT pediatric and young adult patients.

Methods: Patients submitted to HSCT for over 3 years were recruited. Read More

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http://dx.doi.org/10.1111/tid.12903DOI Listing
August 2018
27 Reads

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome associated with cefotaxime and clindamycin use in a 6 year-old boy: a case report.

Pan Afr Med J 2017 9;28:218. Epub 2017 Nov 9.

Healthy Sciences University, Umraniye Training and Research Hospital, Department of Pediatrics, Istanbul, Turkey.

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially life-threatening idiosyncratic drug reaction. It presents with extensive rash, fever, lymphadenopathy, hematologic abnormalities (eosinophilia and/or atypical lymphocytosis) and internal organ involvement. It has been described in association with more than 50 drugs. Read More

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http://dx.doi.org/10.11604/pamj.2017.28.218.10828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881561PMC
May 2018
10 Reads

The immunization status of children with chronic neurological disease and serological assessment of vaccine-preventable diseases.

Hum Vaccin Immunother 2018 14;14(8):1970-1976. Epub 2018 May 14.

d Eskisehir Osmangazi University Faculty of Medicine , Department of Pediatric Intensive Care Unit , Eskisehir , Turkey.

The aim of this study was to evaluate the age-appropriate immunization coverage in 366 children with chronic neurological disease (CND), to evaluate the use of vaccines not included in routine program, to evaluate serological tests for vaccine-preventable diseases and to describe the related factors in unvaccinated children. 95.6% of all children with had received age-appropriate vaccinations according to the actual National Immunization Program (NIP) during childhood. Read More

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http://dx.doi.org/10.1080/21645515.2018.1460986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149706PMC
May 2018
7 Reads

How often do children receive their vaccinations late, and why?

Saudi Med J 2018 Apr;39(4):347-353

Department of Pediatrics, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia. E-mail.

Objectives: To assess vaccination timeliness, risk factors associated with delays and the reasons for delayed vaccinations among children below the age of 3 years in Jeddah, Kingdom of Saudi Arabia.

Methods: This is a cross-sectional study conducted in Jeddah, Saudi Arabia during the period of May 2016 to August 2017. Data were obtained from parents of children under the age of 3 years using a structured questionnaire comprised of questions about sociodemographics, physical well-being of the child and the reasons that are used to justify delayed vaccinations. Read More

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http://dx.doi.org/10.15537/smj.2018.4.21473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938647PMC
April 2018
5 Reads

A phase III, open-label, randomised multicentre study to evaluate the immunogenicity and safety of a booster dose of two different reduced antigen diphtheria-tetanus-acellular pertussis-polio vaccines, when co-administered with measles-mumps-rubella vaccine in 3 and 4-year-old healthy children in the UK.

Vaccine 2018 04 22;36(17):2300-2306. Epub 2018 Mar 22.

Bristol Children's Vaccine Centre, University of Bristol, Upper Maudlin Street, Bristol BS2 8AE, UK.

Aim: To evaluate the immunogenicity and safety of a reduced antigen diphtheria-tetanus-acellular pertussis-inactivated poliovirus (dTap-IPV) vaccine (Boostrix-IPV, GSK) as a pre-school booster in 3-4 year old children as compared to dTap-IPV (Repevax, Sanofi Pasteur), when co-administered with mumps-measles-rubella vaccine (MMRV).

Methods: This phase III, open label, randomised study was conducted in the UK between April 2011 and April 2012. Children due their pre-school dTap-IPV booster vaccination were randomised 2:1 to receive one of two different dTap-IPV vaccines (dTap-IPV or dTap-IPV) with blood sample for immunogenicity assessment just prior and one month after vaccination. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.03.021DOI Listing
April 2018
6 Reads

Prevalence and risk factors of measles seronegativity in a cohort of HIV-positive subjects: a retrospective study.

HIV Med 2018 07 24;19(6):426-429. Epub 2018 Mar 24.

Infectious Diseases Department, CHU Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium.

Objectives: Measles infection is a vaccine-preventable disease currently resurging in Europe. HIV-infected subjects are at higher risk of complications following measles infection. We investigated the risk factors associated with being seronegative in a cohort of HIV-infected subjects. Read More

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http://dx.doi.org/10.1111/hiv.12610DOI Listing
July 2018
3 Reads

Imported case of measles in a university setting leading to an outbreak of measles in Edinburgh, Scotland from September to December 2016.

Epidemiol Infect 2018 04 22;146(6):741-746. Epub 2018 Mar 22.

National Health Service,Lothian,Directorate of Public Health and Health Policy,Edinburgh,UK.

In September 2016, an imported case of measles in Edinburgh in a university student resulted in a further 17 confirmed cases during October and November 2016. All cases were genotype D8 and were associated with a virus strain most commonly seen in South East Asia. Twelve of the 18 cases were staff or students at a university in Edinburgh and 17 cases had incomplete or unknown measles mumps rubella (MMR) vaccination status. Read More

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http://dx.doi.org/10.1017/S0950268818000602DOI Listing
April 2018
9 Reads

Rubella seroprevalence among pregnant women in Beijing, China.

BMC Infect Dis 2018 03 15;18(1):130. Epub 2018 Mar 15.

Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Background: Rubella infection in pregnant women can result in serious effects, such as miscarriages, stillbirths, and congenital rubella syndrome (CRS). However, very little is known about the rubella seroprevalence among pregnant women in China.

Methods: This is a cross-sectional and hospital-based study. Read More

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http://dx.doi.org/10.1186/s12879-018-3032-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856316PMC
March 2018
1 Read

Copper Supplementation in Premature Infants With Parenteral Nutrition-Associated Cholestasis.

Nutr Clin Pract 2018 Oct 12;33(5):718-724. Epub 2018 Mar 12.

Division of Neonatology, Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA.

The aim of this study was to evaluate the effect of intermittent parenteral copper supplementation (IPC) on serum copper status and biochemical and hematological measures of copper toxicity and deficiency in premature infants with parenteral nutrition (PN)-associated cholestasis (PNAC). We performed a prospective nested observational study in premature infants with PNAC who received IPC after the development of PNAC. Infants with chromosomal disorders, TORCH (toxoplasmosis, parvovirus, syphilis, rubella, cytomegalovirus, herpes, human immunodeficiency virus) infection, metabolic disorder, and/or surgical abnormality of the hepatobiliary system were excluded. Read More

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http://dx.doi.org/10.1002/ncp.10053DOI Listing
October 2018
5 Reads