981 results match your criteria Pediatrics Rubella


Measles in healthcare workers during the ongoing epidemic in Greece, 2017-2018.

J Hosp Infect 2018 Jun 11. Epub 2018 Jun 11.

Department of Epidemiologic Surveillance and Intervention, Hellenic Center for Disease Control and Prevention, Athens, Greece.

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Mandatory vaccinations in European countries, undocumented information, false news and the impact on vaccination uptake: the position of the Italian pediatric society.

Ital J Pediatr 2018 Jun 14;44(1):67. Epub 2018 Jun 14.

Bambino Gesù Children Hospital, Pediatric and Infectious Diseases Unit, Rome, Italy.

Background: High rates of vaccination coverage are important in preventing infectious diseases. Enforcing mandatory vaccinations is one of the strategies that some Countries adopted to protect the community when vaccination coverage is not satisfactory. In Italy, in 2017 vaccination against diphtheria, tetanus, pertussis, hepatitis B, poliovirus, Haemophilus influenzae type b, measles, mumps, rubella and varicella became compulsory in childhood. Read More

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Vaccine-preventable diseases, vaccines and Guillain-Barre' syndrome.

Vaccine 2018 Jun 4. Epub 2018 Jun 4.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Perugia, Italy. Electronic address:

Guillain-Barré syndrome (GBS) is an acute, immune-mediated polyradiculoneuropathy. Infections and vaccines have been hypothesized to play a role in triggering GBS development. These beliefs can play a role in reducing vaccination coverage. Read More

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Update From the Advisory Committee on Immunization Practices.

J Pediatric Infect Dis Soc 2018 May;7(2):93-99

Stanford University School of Medicine, California.

The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, each of whom is appointed to a 4-year term. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Read More

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May 2018
4 Reads

Into Darkness and Silence: What Caused Helen Keller's Deafblindness?

Authors:
Janet R Gilsdorf

Clin Infect Dis 2018 May 5. Epub 2018 May 5.

Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan.

In 1882, at 19 months of age, Helen Keller developed a febrile illness that left her both deaf and blind. Historical biographies attribute the illness to rubella, scarlet fever, encephalitis, or meningitis. This analysis of her illness suggests she likely had bacterial meningitis, caused by N. Read More

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May 2018
2 Reads

Decreased antibodies against rubella in previously vaccinated treatment-naïve childhood systemic lupus erythematous patients: a prospective case-control study.

Scand J Rheumatol 2018 May 9:1-3. Epub 2018 May 9.

a Rheumatology and Infectious Diseases Unit, Second Department of Pediatrics, 'P and A Kyriakou' Children's Hospital, Medical School , National and Kapodestrian University of Athens , Athens , Greece.

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TORCH (toxoplasmosis, rubella, cytomegalovirus, and herpes simplex virus) screening of small for gestational age and intrauterine growth restricted neonates: efficacy study in a single institute in Korea.

Korean J Pediatr 2018 Apr 23;61(4):114-120. Epub 2018 Apr 23.

Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Routine screening for toxoplasmosis, rubella, cytomegalovirus (CMV), and herpes simplex virus (TORCH) in intrauterine growth restriction (IUGR) and small for gestational age (SGA) neonates has become a common practice. However, the incidence of TORCH varies across countries, and the cost of TORCH testing may be disadvantageous compared to disease-specific screening. To evaluate the efficacy of TORCH screening, the medical charts of IUGR or SGA neonates born in a single institution in Bucheon, Korea from 2011 to 2015 were reviewed. Read More

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April 2018
14 Reads

Adherence and immune response to revaccination following hematopoietic stem cell transplantation at a pediatric onco-hematology reference center.

Transpl Infect Dis 2018 Apr 18:e12903. Epub 2018 Apr 18.

Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.

Background: Revaccination after hematopoietic stem cell transplantation (HSCT) is necessary to compensate for the loss of immunological memory. The aims of this study were to evaluate the adherence to revaccination schedule and the humoral immune response to different vaccine antigens in HSCT pediatric and young adult patients.

Methods: Patients submitted to HSCT for over 3 years were recruited. Read More

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April 2018
8 Reads

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome associated with cefotaxime and clindamycin use in a 6 year-old boy: a case report.

Pan Afr Med J 2017 9;28:218. Epub 2017 Nov 9.

Healthy Sciences University, Umraniye Training and Research Hospital, Department of Pediatrics, Istanbul, Turkey.

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially life-threatening idiosyncratic drug reaction. It presents with extensive rash, fever, lymphadenopathy, hematologic abnormalities (eosinophilia and/or atypical lymphocytosis) and internal organ involvement. It has been described in association with more than 50 drugs. Read More

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May 2018
1 Read

The immunization status of children with chronic neurological disease and serological assessment of vaccine-preventable diseases.

Hum Vaccin Immunother 2018 Apr 6:1-7. Epub 2018 Apr 6.

d Eskisehir Osmangazi University Faculty of Medicine , Department of Pediatric Intensive Care Unit , Eskisehir , Turkey.

The aim of this study was to evaluate the age-appropriate immunization coverage in 366 children with chronic neurological disease (CND), to evaluate the use of vaccines not included in routine program, to evaluate serological tests for vaccine-preventable diseases and to describe the related factors in unvaccinated children. 95.6% of all children with had received age-appropriate vaccinations according to the actual National Immunization Program (NIP) during childhood. Read More

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How often do children receive their vaccinations late, and why?

Saudi Med J 2018 Apr;39(4):347-353

Department of Pediatrics, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia. E-mail.

Objectives: To assess vaccination timeliness, risk factors associated with delays and the reasons for delayed vaccinations among children below the age of 3 years in Jeddah, Kingdom of Saudi Arabia.

Methods: This is a cross-sectional study conducted in Jeddah, Saudi Arabia during the period of May 2016 to August 2017. Data were obtained from parents of children under the age of 3 years using a structured questionnaire comprised of questions about sociodemographics, physical well-being of the child and the reasons that are used to justify delayed vaccinations. Read More

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A phase III, open-label, randomised multicentre study to evaluate the immunogenicity and safety of a booster dose of two different reduced antigen diphtheria-tetanus-acellular pertussis-polio vaccines, when co-administered with measles-mumps-rubella vaccine in 3 and 4-year-old healthy children in the UK.

Vaccine 2018 04 22;36(17):2300-2306. Epub 2018 Mar 22.

Bristol Children's Vaccine Centre, University of Bristol, Upper Maudlin Street, Bristol BS2 8AE, UK.

Aim: To evaluate the immunogenicity and safety of a reduced antigen diphtheria-tetanus-acellular pertussis-inactivated poliovirus (dTap-IPV) vaccine (Boostrix-IPV, GSK) as a pre-school booster in 3-4 year old children as compared to dTap-IPV (Repevax, Sanofi Pasteur), when co-administered with mumps-measles-rubella vaccine (MMRV).

Methods: This phase III, open label, randomised study was conducted in the UK between April 2011 and April 2012. Children due their pre-school dTap-IPV booster vaccination were randomised 2:1 to receive one of two different dTap-IPV vaccines (dTap-IPV or dTap-IPV) with blood sample for immunogenicity assessment just prior and one month after vaccination. Read More

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Prevalence and risk factors of measles seronegativity in a cohort of HIV-positive subjects: a retrospective study.

HIV Med 2018 Jul 24;19(6):426-429. Epub 2018 Mar 24.

Infectious Diseases Department, CHU Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium.

Objectives: Measles infection is a vaccine-preventable disease currently resurging in Europe. HIV-infected subjects are at higher risk of complications following measles infection. We investigated the risk factors associated with being seronegative in a cohort of HIV-infected subjects. Read More

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July 2018
1 Read

Imported case of measles in a university setting leading to an outbreak of measles in Edinburgh, Scotland from September to December 2016.

Epidemiol Infect 2018 Apr 22;146(6):741-746. Epub 2018 Mar 22.

National Health Service,Lothian,Directorate of Public Health and Health Policy,Edinburgh,UK.

In September 2016, an imported case of measles in Edinburgh in a university student resulted in a further 17 confirmed cases during October and November 2016. All cases were genotype D8 and were associated with a virus strain most commonly seen in South East Asia. Twelve of the 18 cases were staff or students at a university in Edinburgh and 17 cases had incomplete or unknown measles mumps rubella (MMR) vaccination status. Read More

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April 2018
6 Reads

Rubella seroprevalence among pregnant women in Beijing, China.

BMC Infect Dis 2018 03 15;18(1):130. Epub 2018 Mar 15.

Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Background: Rubella infection in pregnant women can result in serious effects, such as miscarriages, stillbirths, and congenital rubella syndrome (CRS). However, very little is known about the rubella seroprevalence among pregnant women in China.

Methods: This is a cross-sectional and hospital-based study. Read More

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Copper Supplementation in Premature Infants With Parenteral Nutrition-Associated Cholestasis.

Nutr Clin Pract 2018 Mar 12. Epub 2018 Mar 12.

Division of Neonatology, Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA.

The aim of this study was to evaluate the effect of intermittent parenteral copper supplementation (IPC) on serum copper status and biochemical and hematological measures of copper toxicity and deficiency in premature infants with parenteral nutrition (PN)-associated cholestasis (PNAC). We performed a prospective nested observational study in premature infants with PNAC who received IPC after the development of PNAC. Infants with chromosomal disorders, TORCH (toxoplasmosis, parvovirus, syphilis, rubella, cytomegalovirus, herpes, human immunodeficiency virus) infection, metabolic disorder, and/or surgical abnormality of the hepatobiliary system were excluded. Read More

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March 2018
3 Reads

Congenital rubella syndrome: A brief review of public health perspectives.

Indian J Public Health 2018 Jan-Mar;62(1):52-54

Professor, Department of Pediatrics, Division of Neonatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Congenital rubella syndrome (CRS) is one of the most devastating congenital infections and yet the only one which is vaccine preventable and is a public health challenge for clinicians and policymakers across the developing world including India. The clinical manifestations of CRS include growth retardation, cardiac defects, cataracts, and hearing impairment. The World Health Organization (WHO) estimates that worldwide over 100,000 babies are born with CRS every year despite the availability of safe and inexpensive vaccines, thus highlighting the need for broader vaccination coverage programs. Read More

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March 2018
1 Read

Prospective Study of Live Attenuated Vaccines for Patients with Nephrotic Syndrome Receiving Immunosuppressive Agents.

J Pediatr 2018 May 28;196:217-222.e1. Epub 2018 Feb 28.

Department of Pediatrics, Yokohama City University, Yokohama, Japan.

Objective: To conduct a prospective study to evaluate the immunogenicity and safety of live attenuated vaccines in patients with nephrotic syndrome receiving immunosuppressive agents.

Study Design: Patients with nephrotic syndrome receiving immunosuppressive agents with negative or borderline antibody titers (virus-specific IgG levels <4.0) against measles, rubella, varicella, and/or mumps fulfilling the criteria of cellular and humoral immunity were enrolled. Read More

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May 2018
2 Reads

Methods for addressing "innocent bystanders" when evaluating safety of concomitant vaccines.

Pharmacoepidemiol Drug Saf 2018 Apr 13;27(4):405-412. Epub 2018 Feb 13.

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital; Department of Medicine, Harvard Medical School, Boston, MA, USA.

Purpose: The need to develop methods for studying the safety of childhood immunization schedules has been recognized by the Institute of Medicine and Department of Health and Human Services. The recommended childhood immunization schedule includes multiple vaccines in a visit. A key concern is safety of concomitant (same day) versus separate day vaccination. Read More

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April 2018
3 Reads

Long-term Seroprotection Rates Following Second Dose of Measles as MMR Vaccine at 15 months in Indian Children.

Indian Pediatr 2018 May 9;55(5):405-407. Epub 2018 Feb 9.

Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Objective: To find out seropositivity rates at 4-6 and 9-12 years of age; among those who received one-dose measles at 9 months and one-dose MMR at 15 months of age.

Methods: 80 healthy children (53 males) at 4-6 or 9-12 years of age, attending outpatient department for vaccination were enrolled. Antibody titers were estimated using commercially available quantitative-IgG ELISA kits. Read More

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May 2018
1 Read

Case 4-2018: A Newborn with Thrombocytopenia, Cataracts, and Hepatosplenomegaly.

N Engl J Med 2018 Feb;378(6):564-572

From the Departments of Pediatrics and Infection Prevention, Yale New Haven Children's Hospital, and the Departments of Pediatrics and Epidemiology, Yale School of Medicine and Yale School of Public Health, New Haven, CT (R.S.B.); the Departments of Radiology (K.N.), Pediatrics (K.A.S., V.M.P.), and Pathology (V.M.P.), Massachusetts General Hospital, and the Departments of Radiology (K.N.), Pediatrics (K.A.S.), and Pathology (V.M.P.), Harvard Medical School - both in Boston; and the Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (S.A.P.).

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February 2018

Safety and immunogenicity of a meningococcal B recombinant vaccine when administered with routine vaccines to healthy infants in Taiwan: A phase 3, open-label, randomized study.

Hum Vaccin Immunother 2018 May 15;14(5):1075-1083. Epub 2018 Feb 15.

f Research and Development Center, GSK , Siena , Italy.

Neisseria meningitidis is associated with high mortality and morbidity in infants and children worldwide. This phase 3 study (NCT02173704) evaluated safety and immunogenicity of a 4-component serogroup B recombinant meningococcal vaccine (4CMenB) co-administered with routine vaccines in Taiwanese infants. In total, 225 healthy infants were randomized (2 : 1 ) to receive 4CMenB and routine vaccines (4CMenB+Routine) or routine vaccines only (Routine group) at 2, 4, 6 and 12 months of age. Read More

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May 2018
15 Reads

Vaccination titres pre- and post-transplant in paediatric renal transplant recipients and the impact of immunosuppressive therapy.

Pediatr Nephrol 2018 May 10;33(5):897-910. Epub 2018 Jan 10.

Department of Paediatrics I, University Children's Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.

Background: Avoidance of vaccine-preventable infections in paediatric renal allograft recipients is of utmost importance. However, the development and maintenance of protective vaccination titres may be impaired in this patient population owing to their need for immunosuppressive medication.

Methods: In the framework of the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN), we therefore performed a multi-centre, multi-national study and analysed vaccination titres pre- and post-transplant in 155 patients with serial titre measurements in comparison with published data in healthy children. Read More

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May 2018
10 Reads

Campaign Mode MMR Vaccination to Control Outbreak of Mumps in a Highly Vaccinated Population: Evidence-based Medicine viewpoint.

Authors:
Joseph L Mathew

Indian Pediatr 2017 12;54(12):1047-1049

Department of Pediatrics, PGIMER, Chandigarh, India.

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December 2017
3 Reads

Zika Virus: An Emerging Global Health Threat.

Front Cell Infect Microbiol 2017 8;7:486. Epub 2017 Dec 8.

Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, United States.

Zika virus (ZIKV) is an emerging healthcare threat. The presence of the mosquito species across South and Central America in combination with complementary climates have incited an epidemic of locally transmitted cases of ZIKV infection in Brazil. As one of the most significant current public health concerns in the Americas, ZIKV epidemic has been a cause of alarm due to its known and unknown complications. Read More

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December 2017
6 Reads

Immunization Practices of U.S. Obstetrician/Gynecologists for Pregnant Patients.

Am J Prev Med 2018 Feb 13;54(2):205-213. Epub 2017 Dec 13.

Adult and Child Consortium for Health Outcomes Research and Delivery Science, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Introduction: U.S. obstetrician/gynecologists play a critical role as vaccinators of pregnant women. Read More

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February 2018
6 Reads

Fetal Anemia Causing Hydrops Fetalis From an Alpha-Globin Variant: Homozygous Hemoglobin Constant Spring.

J Pediatr Hematol Oncol 2017 Dec 12. Epub 2017 Dec 12.

Center for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Muang, Khon Kaen, Thailand.

Background: Fetal anemia is often assumed to be due to red cell alloimmunization and Parvovirus infection, and can lead to hydrops fetalis and death in utero. Other causes, such as mutations of hemoglobin alpha, are less commonly considered.

Methods: We report 7 cases with fetal anemia causing hydrops fetalis. Read More

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December 2017
11 Reads

Vaccination Practices in Pediatric Dialysis Patients Across Europe. A European Pediatric Dialysis Working Group and European Society for Pediatric Nephrology Dialysis Working Group Study.

Nephron 2018 12;138(4):280-286. Epub 2017 Dec 12.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Data on the immunization practices in pediatric chronic kidney disease (CKD) patients are scarce. The purpose of this study was to evaluate current vaccination practices for children on dialysis across European pediatric nephrology centers.

Methods: A total of 18 tertiary pediatric nephrology centers from 12 European countries were included in the study. Read More

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December 2017
21 Reads

One or two doses of live varicella virus-containing vaccines: Efficacy, persistence of immune responses, and safety six years after administration in healthy children during their second year of life.

Vaccine 2018 01 7;36(3):381-387. Epub 2017 Dec 7.

Vaccine Discovery and Development, GSK, Philadelphia, United States. Electronic address:

Background: This phase III B follow-up of an initial multicenter study (NCT00226499) will evaluate the ten-year efficacy of two doses of the combined measles-mumps-rubella-varicella vaccine (MMRV) and one dose of the live attenuated varicella vaccine (V) versus a measles-mumps-rubella control group (MMR) for the prevention of clinical varicella disease. Here we present efficacy results for six years post-vaccination.

Methods: In phase A of the study, healthy children aged 12-22 months from ten European countries were randomized (3:3:1) and received either two doses of MMRV, or one dose of combined MMR and one dose of monovalent varicella vaccine (MMR+V), or two doses of the MMR vaccine (control), 42 days apart. Read More

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January 2018
10 Reads

The burden of congenital rubella syndrome in the Philippines: results from a retrospective assessment.

Western Pac Surveill Response J 2017 Apr-Jun;8(2):17-24. Epub 2017 Jun 13.

Department of Health, Philippines.

Introduction: In line with the regional aim of eliminating rubella and congenital rubella syndrome (CRS), phased introduction of rubella-containing vaccines (RCV) in the Philippines' routine immunization programme began in 2010. We estimated the burden of CRS in the country before widespread nationwide programmatic RCV use.

Methods: We performed a retrospective chart review in four tertiary hospitals. Read More

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May 2018
2 Reads

Association between false-positive TORCH and antiphospholipid antibodies in healthy pregnant women.

Lupus 2018 Apr 20;27(5):841-846. Epub 2017 Nov 20.

1 Department of Obstetrics, Gynaecology and Pediatrics, Catholic University of Sacred Heart, Rome, Italy.

The present study investigated: (a) the presence of antiphospholipid antibodies and (b) the obstetric outcome in healthy pregnant women showing false-positive TORCH-Toxoplasmosis, Other: syphilis, varicella-zoster, Rubella, Cytomegalovirus (CMV), and Herpes infections-results. Data from 23 singleton healthy pregnancies with false-positive TORCH results were collected. Each woman was systematically screened for TORCH IgG and IgM during the pre-conception assessment and/or at the beginning of pregnancy. Read More

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April 2018
1 Read

Cadherin-related Family Member 3 Genetics and Rhinovirus C Respiratory Illnesses.

Am J Respir Crit Care Med 2018 Mar;197(5):589-594

1 Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

Rationale: Experimental evidence suggests that CDHR3 (cadherin-related family member 3) is a receptor for rhinovirus (RV)-C, and a missense variant in this gene (rs6967330) is associated with childhood asthma with severe exacerbations.

Objectives: To determine whether rs6967330 influences RV-C infections and illnesses in early childhood.

Methods: We studied associations between rs6967330 and respiratory infections and illnesses in the COPSAC (Copenhagen Prospective Studies on Asthma in Childhood 2010) and COAST (Childhood Origins of Asthma Birth Cohort Study) birth cohorts, where respiratory infections were monitored prospectively for the first 3 years of life. Read More

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March 2018
4 Reads

County-level assessment of United States kindergarten vaccination rates for measles mumps rubella (MMR) for the 2014-2015 school year.

Vaccine 2017 11 14;35(47):6444-6450. Epub 2017 Oct 14.

Computational Epidemiology Group, Children's Hospital Informatics Program, Division of Emergency Medicine, Boston Children's Hospital, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. Electronic address:

United States kindergarten measles-mumps-rubella (MMR) vaccination rates are typically reported at the state level by the Centers for Disease Control and Prevention (CDC). The lack of local MMR data prevents identification of areas with low vaccination rates that would be vulnerable to the spread of disease. We collected county-level vaccination rates for the 2014-2015 school year with the objective of identifying these regions. Read More

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November 2017
5 Reads

Update From the Advisory Committee on Immunization Practices.

J Pediatric Infect Dis Soc 2017 Nov;6(4):311-316

Department of Pediatrics, University of Alabama at Birmingham.

The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Read More

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November 2017
1 Read

Screening investigations in small-for-gestational-age near-term and term infants.

Eur J Pediatr 2017 Dec 10;176(12):1707-1712. Epub 2017 Oct 10.

Monash Newborn, Monash Children's Hospital, Melbourne, Australia.

The aims of this study are to examine how frequently near-term and term small-for-gestational-age (SGA) infants were investigated in our clinical practice, whether being born less than the third centile for weight increased the yield of positive investigations, and whether there were additional characteristics in infants with positive investigations. This retrospective cohort study was compiled using a database of a large maternity network, using the search near term and term gestational age (greater than or equal to 35 weeks) over a span of 4 years. SGA babies were further filtered into less than the tenth centile and third centile. Read More

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December 2017
3 Reads

The pathogenesis of microcephaly resulting from congenital infections: why is my baby's head so small?

Eur J Clin Microbiol Infect Dis 2018 Feb 5;37(2):209-226. Epub 2017 Oct 5.

Department of Virology, Faculty of Basic Medical Sciences, Tarbiat Modares University, Tehran, Iran.

The emergence of Zika-virus-associated congenital microcephaly has engendered renewed interest in the pathogenesis of microcephaly induced by infectious agents. Three of the original "TORCH" agents are associated with an appreciable incidence of congenital microcephaly: cytomegalovirus, rubella virus, and Toxoplasma gondii. The pathology of congenital microcephaly is characterized by neurotropic infectious agents that involve the fetal nervous system, leading to brain destruction with calcifications, microcephaly, sensorineural hearing loss, and ophthalmologic abnormalities. Read More

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February 2018
2 Reads

Detection of human parvovirus B19 in serum samples from children under 5 years of age with rash-fever illnesses in the Democratic Republic of the Congo.

Int J Infect Dis 2017 Dec 22;65:4-7. Epub 2017 Sep 22.

University Hospital of Kinshasa, Faculty of Medicine, Department of Microbiology, Kinshasa, Congo; National Institute for Biomedical Research (INRB), Kinshasa, Congo.

Background: It has been demonstrated that infection with human parvovirus B19 (B19V) is associated with rash-fever illnesses. The present study aimed to investigate B19V as an aetiological agent of rash-fever syndromes in Congolese children confirmed as measles and rubella IgM-negative. An ELISA IgM test and PCR were performed to screen for B19V. Read More

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December 2017
4 Reads

Prevention and assessment of infectious diseases among children and adult migrants arriving to the European Union/European Economic Association: a protocol for a suite of systematic reviews for public health and health systems.

BMJ Open 2017 Sep 11;7(9):e014608. Epub 2017 Sep 11.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.

Introduction: The European Centre for Disease Prevention and Control is developing evidence-based guidance for voluntary screening, treatment and vaccine prevention of infectious diseases for newly arriving migrants to the European Union/European Economic Area. The objective of this systematic review protocol is to guide the identification, appraisal and synthesis of the best available evidence on prevention and assessment of the following priority infectious diseases: tuberculosis, HIV, hepatitis B, hepatitis C, measles, mumps, rubella, diphtheria, tetanus, pertussis, poliomyelitis (polio), disease, strongyloidiasis and schistosomiasis.

Methods And Analysis: The search strategy will identify evidence from existing systematic reviews and then update the effectiveness and cost-effectiveness evidence using prospective trials, economic evaluations and/or recently published systematic reviews. Read More

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September 2017
22 Reads

Non-specific effects of measles, mumps, and rubella (MMR) vaccination in high income setting: population based cohort study in the Netherlands.

BMJ 2017 Aug 30;358:j3862. Epub 2017 Aug 30.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment, 3720 BA Bilthoven, Netherlands

 To investigate whether measles, mumps, and rubella (MMR) vaccine has positive non-specific effects in a high income setting and to compare rates of hospital admissions for infections between children aged ≤2 years who received live MMR vaccine and those who received an inactivated vaccine against diphtheria, tetanus, pertussis, polio, and type b (DTaP-IPV-Hib) as their most recent vaccination. Nationwide population based cohort study. In the Netherlands, DTaP-IPV-Hib+pneumococcal vaccination (PCV) is recommended at ages 2, 3, 4, and 11 months and MMR + meningococcal C (MenC) vaccination at age 14 months. Read More

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August 2017
13 Reads

The utility of measles and rubella IgM serology in an elimination setting, Ontario, Canada, 2009-2014.

PLoS One 2017 29;12(8):e0181172. Epub 2017 Aug 29.

Hastings Prince Edward Public Health, Belleville, Ontario, Canada.

In Canada, measles was eliminated in 1998 and rubella in 2000. Effective measles and rubella surveillance is vital in elimination settings, hinging on reliable laboratory methods. However, low-prevalence settings affect the predictive value of laboratory tests. Read More

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October 2017
5 Reads

Infectious causes of microcephaly: epidemiology, pathogenesis, diagnosis, and management.

Lancet Infect Dis 2018 Jan 30;18(1):e1-e13. Epub 2017 Aug 30.

Institute for Global Health, University College London, London, UK.

Microcephaly is an important sign of neurological malformation and a predictor of future disability. The 2015-16 outbreak of Zika virus and congenital Zika infection brought the world's attention to links between Zika infection and microcephaly. However, Zika virus is only one of the infectious causes of microcephaly and, although the contexts in which they occur vary greatly, all are of concern. Read More

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January 2018
3 Reads

Evaluation of Combination Measles-Mumps-Rubella-Varicella Vaccine Introduction in Australia.

JAMA Pediatr 2017 Oct;171(10):992-998

National Centre for Immunisation Research and Surveillance, Sydney, Australia.

Importance: Incorporating combination vaccines, such as the measles-mumps-rubella-varicella (MMRV) vaccine, into immunization schedules should be evaluated from a benefit-risk perspective. Use of MMRV vaccine poses challenges due to a recognized increased risk of febrile seizures (FSs) when used as the first dose in the second year of life. Conversely, completion by age 2 years of measles, mumps, rubella, and varicella immunization may offer improved disease control. Read More

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October 2017
15 Reads

Utility of routine urine CMV PCR and total serum IgM testing of small for gestational age infants: a single center review.

J Perinat Med 2018 Jan;46(1):81-86

Department of Pediatrics, Division of Neonatology, New York University School of Medicine, New York, NY 10016, USA.

Background: Due to the extremely low incidence of TORCH (toxoplasmosis, rubella, CMV, herpes simplex virus) infections, diagnostic testing of all small for gestational age (SGA) infants aimed at TORCH etiologies may incur unnecessary tests and cost.

Objective: To determine the frequency of urine CMV PCR and total IgM testing among infants with birth weight <10% and the rate of test positivity. To evaluate the frequency of alternative etiologies of SGA in tested infants. Read More

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January 2018
1 Read

Chronically ill adolescents are also incompletely vaccinated: A cross-sectional study in France.

Vaccine 2017 08 29;35(36):4707-4712. Epub 2017 Jul 29.

Department of Pediatrics, University of Nantes, Nantes, France; National Institutes of Health and Medical Research, CIC 1413, University Hospital of Nantes, Nantes, France.

Background: Adolescent vaccination coverage tends to be suboptimal, leading to resurgent infectious pathologies and vulnerability to various pathogens. The low frequency of medical consultations and missed opportunities for vaccination are often used to explain the low rate of vaccination. The aim of this study was to assess if the vaccination coverage rate is higher in chronically ill adolescents (CIA) who require a close pediatric specialized follow-up versus the rate in healthy adolescents (HA). Read More

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August 2017
5 Reads

Subacute sclerosing panencephalitis should be eliminated by measles vaccination.

Hum Vaccin Immunother 2017 Sep;13(9):2038-2040

a Department of Pediatrics , Affiliated Hospital of Guizhou Medical University , Guiyang , China.

1 patient with SSPE at 4 y. He had had measles and measles encephalitis at 7.5 months. Read More

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September 2017
9 Reads

Vaccine-preventable diseases in pediatric patients: a review of measles, mumps, rubella, and varicella [digest].

Pediatr Emerg Med Pract 2016 Dec 22;13(12 Suppl Points & Pearls):S1-S2. Epub 2016 Dec 22.

Pediatric Emergency Medicine Chief Fellow, Emergency & Transport Medicine, Children's Hospital Los Angeles, Keck School of Medicine/University of Southern California, Los Angeles, CA.

Vaccine-preventable diseases such as measles, mumps, rubella, and varicella continue to plague children and adults worldwide. Although public health programs have helped decrease the prevalence and sequelae of these diseases, outbreaks still occur. To limit the spread of these diseases, emergency clinicians must be able to readily identify the characteristic presentations of the rashes associated with measles, rubella, and varicella, as well as the common presenting features associated with mumps. Read More

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December 2016
14 Reads

Autoimmune/inflammatory syndrome leading to macrophage activation syndrome: An example of autoinflammatory spectrum disorder?

Isr Med Assoc J 2016 Sep;18(9):571

Department of Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland.

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September 2016
3 Reads

Congenital rubella syndrome: an unusual cause of neonatal fulminant hepatic failure.

Trop Doct 2018 01 5;48(1):66-68. Epub 2017 Jul 5.

2 Associate Professor, Department of Pediatrics, Chacha Nehru Bal Chikitsalaya, Delhi 31, India.

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January 2018
2 Reads

Vaccination in newly arrived immigrants to the European Union.

Vaccine 2017 Jun 8. Epub 2017 Jun 8.

Biovomed, Hradec Kralove, Czech Republic.

The challenge of assimilating millions of immigrants in the European region each year presents significant socioeconomic issues. Among them is the threat of vaccine preventable diseases (VPDs) disease transmission within immigrant groups and the broader population given the permeability of nation state borders. A total of 3. Read More

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June 2017
3 Reads

Media and Measles-Rubella Vaccination Campaign - Musings from Pondicherry.

Indian Pediatr 2017 05;54(5):421-422

Department of Neonatology and #Pediatrics JIPMER, Pondicherry, India.

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May 2017
1 Read