1,169 results match your criteria Pediatrics Rubella

Risk of Vaccine-Preventable Infections in Swiss Adults with Inflammatory Bowel Disease.

Digestion 2021 May 10:1-9. Epub 2021 May 10.

Department of Pediatrics, Pediatric Infectious Disease Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

Background: Patients with inflammatory bowel disease (IBD) have a higher risk of infection and are frequently not up to date with their immunizations.

Objectives: This study aims to review vaccination status and evaluate whether age, disease type, or treatment regimen could predict the absence of seroprotection against selected vaccine-preventable infection in adults with IBD.

Methods: Cross-sectional study using questionnaire, immunization records review, and assessment of tetanus-specific, varicella-specific, and measles-specific immunoglobulin G concentrations. Read More

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Needle Fear among Children during Mass Measles Rubella (MR) Injectable Vaccination Campaign in North India: an Observational Study.

J Child Adolesc Trauma 2021 Apr 24:1-6. Epub 2021 Apr 24.

Surveillance Medical Unit Office, World Health Organization, Panchkula, Haryana India.

The cross-sectional observational study evaluated the prevalence and predictors of needle-fear among school-going children during mass Measles-Rubella (MR) immunization campaign (year 2017) in the north Indian city of Chandigarh. Fear of needle was assessed using a single-item self-report global question, anxiety was assessed using the Likert scale (score 1-5) and the standardized "Children Faces Scale" where facial responses were graded from 0 to 4. Out of a total sample of 2568 school children, 1225 (47. Read More

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Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019.

Euro Surveill 2021 Apr;26(17)

Department of Paediatrics and Adolescent Medicine, The Juliane Marie Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

BackgroundHealthcare workers (HCW) have been identified as index cases in disease outbreaks of vaccine-preventable diseases (VPD) in hospitals.AimWe investigated whether Danish paediatric HCW were protected against selected serious VPD.MethodsWe included 90% of staff members from two paediatric departments. Read More

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Ten-year follow-up on efficacy, immunogenicity and safety of two doses of a combined measles-mumps-rubella-varicella vaccine or one dose of monovalent varicella vaccine: Results from five East European countries.

Vaccine 2021 May 12;39(19):2643-2651. Epub 2021 Apr 12.

GSK, Wavre, Belgium. Electronic address:

Background: We assessed the 10-year efficacy, immunogenicity and safety of two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV) or one dose of a monovalent varicella vaccine (V) in children from Czech Republic, Lithuania, Poland, Romania and Slovakia.

Methods: This was a phase IIIB follow-up of an observer-blind, randomized, controlled trial (NCT00226499). In phase A, healthy children aged 12-22 months from 10 European countries were randomized in a 3:3:1 ratio to receive two doses of MMRV (MMRV group), one dose of MMR followed by one dose of V (MMR + V group), or two doses of MMR (MMR; control group), 42 days apart. Read More

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An Immune Recovery-Based Revaccination Protocol for Pediatric Hematopoietic Stem Cell Transplant Recipients: Revaccination Outcomes Following Pediatric HSCT.

Transplant Cell Ther 2021 Apr 28;27(4):317-326. Epub 2021 Jan 28.

Division of Pediatric Infectious Diseases, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado.

Following hematopoietic stem cell transplant (HSCT), patients are at increased risk of vaccine-preventable diseases (VPDs) and experience worse outcomes of VPDs compared to immunocompetent patients. Therefore, patients are routinely vaccinated post-HSCT to restore VPD immunity. Published guidelines recommend revaccination based on time post-HSCT, although optimal revaccination timing and the value of using other clinical and laboratory variables to guide revaccination remain unclear. Read More

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Immunogenicity and safety of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine administered concomitantly with other paediatric vaccines in toddlers: a phase III randomised study.

Epidemiol Infect 2021 Apr 5;149:e90. Epub 2021 Apr 5.

Global Clinical Sciences, Sanofi Pasteur, Swiftwater, PA, USA.

Invasive meningococcal disease has high morbidity and mortality, with infants and young children among those at greatest risk. This phase III, open-label, randomised study in toddlers aged 12-23 months evaluated the immunogenicity and safety of meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT), a tetanus toxoid conjugated vaccine against meningococcal serogroups A, C, W and Y, when coadministered with paediatric vaccines (measles, mumps and rubella [MMR]; varicella [V]; 6-in-1 combination vaccine against diphtheria, tetanus, pertussis, polio, hepatitis B and Haemophilus influenzae type b [DTaP-IPV-HepB-Hib] and pneumococcal conjugate vaccine [PCV13])(NCT03205371). Immunogenicity to each meningococcal serogroup was assessed by serum bactericidal antibody assay using human complement (hSBA). Read More

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Three-Year Clinical Follow-Up of Children Intrauterine Exposed to Zika Virus.

Viruses 2021 03 22;13(3). Epub 2021 Mar 22.

Pediatrics Department, Jundiaí Medical School, Jundiaí 13202-550, Brazil.

Congenital Zika virus (ZIKV) infection may present with a broad spectrum of clinical manifestations. Some sequelae, particularly neurodevelopmental problems, may have a later onset. We conducted a prospective cohort study of 799 high-risk pregnant women who were followed up until delivery. Read More

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Association between Viral Infections and Risk of Autistic Disorder: An Overview.

Int J Environ Res Public Health 2021 03 10;18(6). Epub 2021 Mar 10.

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.

Autism spectrum disorder (ASD) is a neurodevelopmental condition of the central nervous system (CNS) that presents with severe communication problems, impairment of social interactions, and stereotypic behaviours. Emerging studies indicate possible associations between viral infections and neurodegenerative and neurobehavioural conditions including autism. Viral infection during critical periods of early in utero neurodevelopment may lead to increased risk of autism in the offspring. Read More

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Vaccine hesitancy and reported non-vaccination in an Irish pediatric outpatient population.

Eur J Pediatr 2021 Mar 27. Epub 2021 Mar 27.

Department of General Pediatrics, CHI at Temple Street, Dublin, Ireland.

Vaccine hesitancy is defined as a delay in acceptance, or refusal, of vaccines, despite availability. It is a complex and context specific phenomenon and identified as a global health priority. The "Parent Attitudes about Childhood Vaccines" (PACV) questionnaire is a validated tool for identifying vaccine hesitancy. Read More

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Vaccine coverage among children with epilepsy in two Canadian provinces: A Canadian immunization research network study.

Vaccine 2021 Apr 13;39(15):2117-2123. Epub 2021 Mar 13.

Institute for Clinical Evaluative Sciences, Ottawa, ON, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, ON, Canada.

Objectives: Children with epilepsy are at increased risk of complications from vaccine-preventable infections, yet information on vaccine coverage in these children is scarce. We aimed to compare vaccine coverage among children with epilepsy to children without epilepsy.

Study Design: We conducted a retrospective cohort study including all 2005-2013 births in Manitoba and Ontario, Canada, creating two cohorts: 2-year-olds and 7-year-olds (followed to age 2 and 7 years). Read More

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Mumps Antibody Titer in MMR-Vaccinated and Vaccine Naïve Children at a Public Hospital in Delhi.

Indian Pediatr 2021 Feb;58(2):137-139

Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.

Objective: To compare the mumps antibody titers in Measles-Mumps-Rubella (MMR)-vaccinated and vaccine naive children.

Methods: This cross-sectional study was conducted at a tertiary-care public hospital in Delhi from November, 2016 to April, 2018 among 78 healthy children (aged 16 month-12 years) attending the pediatric outpatient department. Serum IgG and IgM rubella antibodies were measured by ELISA for confirmation of MMR vaccination status. Read More

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February 2021

Adverse events associated with Measles and Rubella vaccination campaign 2019 in India.

Clin Exp Vaccine Res 2021 Jan 31;10(1):44-46. Epub 2021 Jan 31.

Department of Paediatrics, Kamla Raja Hospital, Gajra Raja Medical College, Gwalior, India.

Purpose: The purpose of this study is to study the various adverse reactions caused post measles and rubella vaccination done during measles rubella (MR) vaccine campaign in India.

Materials And Methods: Prospective, observational study was done in a government tertiary care pediatric intensive care unit. Children aged between 9 months to 15 years, who presented with adverse effects (severe enough to warrant admission) within 7 days of MR vaccine administration. Read More

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January 2021

Suboptimal Vaccination Administration in Mothers With Inflammatory Bowel Disease and Their Biologic-Exposed Infants.

Inflamm Bowel Dis 2021 Feb 20. Epub 2021 Feb 20.

Department of Community Health Sciences, University of Calgary, Alberta, Canada.

Background: Pregnant women with inflammatory bowel disease (IBD) are at increased risk of developing complications from vaccine-preventable infections. We investigated the factors influencing vaccine administration in pregnant women with IBD and their infants, in addition to the safety of vaccination in the infants.

Methods: This retrospective cohort study identified individuals from a tertiary referral clinic whose records were linked to a provincial vaccine database. Read More

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February 2021

The Importance of Advancing Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines in Children.

Clin Infect Dis 2021 02;72(3):515-518

Department of Pediatrics, Emory University School of Medicine, Emory + Children's Pediatric Institute, Atlanta, Georgia, USA.

While the role of children in the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains to be defined, children likely play an important role based on our knowledge of other respiratory viruses. Children are more likely to be asymptomatic or have milder symptoms and less likely to present for healthcare and be tested for SARS-CoV-2. Thus, our current estimates are likely under-representative of the true burden of SARS-CoV-2 in children. Read More

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February 2021

Assessing the burden of congenital rubella syndrome in China and evaluating mitigation strategies: a metapopulation modelling study.

Lancet Infect Dis 2021 Jan 27. Epub 2021 Jan 27.

National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: A rubella vaccine was licensed in China in 1993 and added to the Expanded Programme on Immunization in 2008, but a national cross-sectional serological survey during 2014 indicates that many adolescents remain susceptible. Maternal infections during the first trimester often cause miscarriages, stillbirths, and, among livebirths, congenital rubella syndrome. We aimed to evaluate possible supplemental immunisation activities (SIAs) to accelerate elimination of rubella and congenital rubella syndrome. Read More

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January 2021

Thoughts, beliefs and concepts concerning infectious childhood diseases of physicians practicing homeopathic, anthroposophic and conventional medicine - a qualitative study.

BMC Complement Med Ther 2021 Jan 26;21(1):46. Epub 2021 Jan 26.

Institute for Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin, Luisenstr. 57, 10117, Berlin, Germany.

Background: Physicians who include complementary medicine in their practice are thought to have an understanding of health and disease different from that of colleagues practicing conventional medicine. The aim of this study was to identify and compare the thoughts and concepts concerning infectious childhood diseases (measles, mumps, rubella, chickenpox, pertussis and scarlet fever) of physicians practicing homeopathic, anthroposophic and conventional medicine.

Methods: This qualitative study used semistructured interviews. Read More

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January 2021

Vaccinating Children against Covid-19 - The Lessons of Measles.

N Engl J Med 2021 Feb 20;384(7):589-591. Epub 2021 Jan 20.

From the Department of Journalism, New York University (P.K.), and the Departments of Pediatrics (P.K., A.J.R.) and Microbiology (A.J.R.), and the Division of Pediatric Infectious Diseases (A.J.R.), Grossman School of Medicine, New York University, New York.

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February 2021

Arthritis associated with Mycoplasma pneumoniae in a pediatric patient: A case report.

Medicine (Baltimore) 2021 Jan;100(2):e24316

Department of Pediatrics.

Introduction: Mycoplasma pneumoniae (MP) infection in infants is usually overlooked and it might result in important complications if left untreated. MP-induced arthritis is probably the least common extrapulmonary manifestation and frequently leads to delays in the diagnosis.

Patient Concerns: We report the case of a 2-year-old female child admitted in our clinic for prolonged fever (onset 2 weeks before the admission), for which the general practitioner established the diagnosis of acute pharyngitis and recommended antibiotics. Read More

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January 2021

A modern measles outbreak: understanding maternal immunity and impact on postpartum vaccination uptake.

Am J Obstet Gynecol MFM 2021 Jan 13;3(3):100309. Epub 2021 Jan 13.

Department of Obstetrics and Gynecology, New York University Grossman School of Medicine, New York University Langone Health, New York, NY.

Background: In October 2018, a measles (rubeola) outbreak was identified in New York City and Rockland County, and a public health campaign and hospital policy changes were made to increase awareness of the importance of vaccination and increase vaccination rates.

Objective: We describe the prevalence of rubeola immunity in pregnant women and the change in uptake of postpartum measles, mumps, and rubella vaccination before and during the measles outbreak.

Study Design: A multipronged intervention was developed by the health system with the intent of raising awareness of the outbreak, identifying patients at risk of contracting measles during pregnancy, and limiting exposure of inpatients to the disease. Read More

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January 2021

Suboptimal vaccination coverage of recommended vaccines among French children with recurrent autoinflammatory fever syndromes: a study from the Juvenile Inflammatory Rheumatism cohort.

Clin Rheumatol 2021 Jan 13. Epub 2021 Jan 13.

Department of General Pediatrics, Versailles Hospital, 177 rue de Versailles, 78150, Le Chesnay, Paris, France.

Introduction/objectives: To determine vaccination coverage among a French cohort of children with recurrent autoinflammatory fever syndromes (RFS).

Method: All RFS children aged 2 to 19 years from the Juvenile Inflammatory Rheumatism cohort and followed at the French Reference Center for Autoinflammatory Diseases, Versailles Hospital, were included in our observational study. Immunisation status at ages 2, 7 and 15 years and at the last outpatient visit was evaluated according to the standard French vaccine schedule and recommended supplementary vaccines for patients with immunosuppressive therapy. Read More

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January 2021

Modeling human adaptive immune responses with tonsil organoids.

Nat Med 2021 01 11;27(1):125-135. Epub 2021 Jan 11.

Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.

Most of what we know about adaptive immunity has come from inbred mouse studies, using methods that are often difficult or impossible to confirm in humans. In addition, vaccine responses in mice are often poorly predictive of responses to those same vaccines in humans. Here we use human tonsils, readily available lymphoid organs, to develop a functional organotypic system that recapitulates key germinal center features in vitro, including the production of antigen-specific antibodies, somatic hypermutation and affinity maturation, plasmablast differentiation and class-switch recombination. Read More

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January 2021

Infant immunity against viral infections is advanced by the placenta-dependent vertical transfer of maternal antibodies.

Vaccine 2021 Jan 8. Epub 2021 Jan 8.

Division for Experimental Feto-Maternal Medicine, Department of Obstetrics and Prenatal Medicine, University Medical Center of Hamburg-Eppendorf, Germany. Electronic address:

Neonatal passive immunity, derived from transplacental transfer of IgG antibodies from mother to fetus during pregnancy, can mitigate the risk for severe infections in the early postnatal period. Understanding the placenta as the gateway organ in this process, we aimed to evaluate the influence of specific factors modulating the transplacental IgG transfer rate (TPTR) in 141 mother/neonate pairs. We further evaluated the potential health advantage elicited by maternal IgG with regard to respiratory tract infections during infancy and early childhood. Read More

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January 2021

Viral seroprevalence in pediatric kidney transplant recipients.

Turk Pediatri Ars 2020 16;55(4):418-424. Epub 2020 Dec 16.

Division of Pediatric Nephrology, Department of Pediatrics, Akdeniz University Faculty of Medicine, Antalya, Turkey.

Aim: Viral infections commonly affect kidney transplant recipients and may lead to graft failure and death. The aim of this study was to evaluate the antibody seroprevalence against viral agents in kidney transplant recipients.

Material And Methods: The records of children who underwent kidney transplantation between 2008 and 2018 in Akdeniz University Faculty of Medicine were retrospectively reviewed. Read More

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December 2020

Childhood vaccinations: Hidden impact of COVID-19 on children in Singapore.

Vaccine 2021 01 26;39(5):780-785. Epub 2020 Dec 26.

Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore.

Although the direct health impact of Coronavirus disease (COVID-19) pandemic on child health is low, there are indirect impacts across many aspects. We compare childhood vaccine uptake in three types of healthcare facilities in Singapore - public primary care clinics, a hospital paediatric unit, and private paediatrician clinics - from January to April 2020, to baseline, and calculate the impact on herd immunity for measles. We find a 25. Read More

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January 2021

Changes in awareness and knowledge concerning mother-to-child infections among Japanese pregnant women between 2012 and 2018.

PLoS One 2021 6;16(1):e0244945. Epub 2021 Jan 6.

Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.

This study aimed to investigate the long-term changes in awareness of and knowledge about mother-to-child infections across 6 years in Japan. A questionnaire survey was conducted at our facility from October 2012 to January 2018, and the study periods were divided into 4 phases comprising 16 months each. A multiple-choice questionnaire assessed participants' awareness of the following 13 pathogens of mother-to-child infections: cytomegalovirus (CMV), Toxoplasma gondii (T. Read More

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Newborn with bilateral congenital cataracts: Never forget congenital rubella syndrome.

Paediatr Child Health 2020 Mar 16;25(2):72-76. Epub 2019 Mar 16.

Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario.

A term, growth-restricted newborn presented with a sepsis-like picture, persistent pulmonary hypertension and bilateral cataracts. Initial review of prenatal and family history, as well as microbiological investigations were noncontributory. Following lenticular extraction, viral examination of the lenses confirmed the presence of rubella. Read More

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50 Years Ago in TheJournalofPediatrics: The Status of Measles and Rubella Immunization in the United States.

Scott D Krugman

J Pediatr 2021 01;228:154

Herman & Walter Samuelson Children's Hospital at Sinai, Baltimore, Maryland.

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January 2021

Fetal Rhesus Monkey First Trimester Zika Virus Infection Impacts Cortical Development in the Second and Third Trimesters.

Cereb Cortex 2021 Mar;31(5):2309-2321

Department of Psychiatry and Behavioral Science, School of Medicine, University of California, Davis, Davis, CA 95817, USA.

Zika virus is a teratogen similar to other neurotropic viruses, notably cytomegalovirus and rubella. The goal of these studies was to address the direct impact of Zika virus on fetal development by inoculating early gestation fetal rhesus monkeys using an ultrasound-guided approach (intraperitoneal vs. intraventricular). Read More

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Clinical profile and outcome of early surgery in neonatal-onset glaucoma presenting over a 5-year period.

Br J Ophthalmol 2020 Dec 2. Epub 2020 Dec 2.

Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Neonatal-onset glaucoma (NOG) is a severe form of childhood glaucoma and is not always due to primary congenital glaucoma (PCG). Due to advances in neonatal care, the incidence of NOG is rising, but it remains an under-reported entity. The objective of the paper was to study the clinical profiles, surgical and visual outcomes of NOG at least 1 year following early surgery. Read More

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December 2020