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J Dermatol 2018 Oct 27;45(10):1199-1202. Epub 2018 Jul 27.

Department of Pediatrics, Showa General Hospital, Tokyo, Japan.

Infantile hemangiomas grow rapidly during infancy followed by gradual involution. After involution, residual lesions sometimes remain. Despite the prognosis for eventual involution, infantile hemangiomas often cause great psychosocial morbidity that affects patients and their parents. Read More

J Med Virol 2018 Nov 13;90(11):1757-1764. Epub 2018 Aug 13.

HerpeZ, University Teaching Hospital, Lusaka, Zambia.

Background: Human herpesvirus 6B (HHV-6B) is the causative agent of Roseola infantum, and has also been suggested to play a role in the pathogenesis of febrile seizures in young children, a percentage of whom go on to develop febrile status epilepticus (FSE), but the existing data is conflicting and inconclusive. HHV-6A is a distinct species, rarely detected in most parts of the world, but prior studies suggest a higher prevalence in febrile African children. We describe a case-control study comparing the frequency of HHV-6A and/or HHV-6B infections in children with febrile seizures (including FSE) and a control group of febrile children without seizures. Read More

J Med Virol 2018 Oct 10;90(10):1636-1642. Epub 2018 Jul 10.

Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

The objectives of the work are to elucidate the incidence and virological findings of chromosomally integrated human herpesvirus 6 (ciHHV-6) in Japanese population and to analyze an association between ciHHV-6 and the clinical manifestation of exanthema subitum (ES). Real-time polymerase chain reaction was performed to determine HHV-6 DNA loads in 2347 cord blood samples from healthy neonates (cohort A), febrile children less than 5 years old (cohort B), and hematopoietic cell transplant recipients (cohort C). CiHHV-6 was confirmed by detection of high copy numbers of viral DNA in somatic cells. Read More

Neuropathology 2018 Mar 26. Epub 2018 Mar 26.

Department of Pediatrics, Oita University Faculty of Medicine, Yufu, Japan.

Human herpes virus 6 (HHV-6) is known to cause primary encephalitis in the frontal lobes/cerebral hemisphere or reactivated encephalitis in the hippocampus, but the pathogenesis remains unclear. HHV-6B has also been detected in hippocampal samples in patients with mesial temporal lobe epilepsy. A 1 year and 3 months old female, who had been clinically diagnosed with exanthema subitum and febrile convulsion, was found dead on the third day after onset. Read More

Brain Dev 2018 Mar 25;40(3):242-246. Epub 2017 Sep 25.

Department of Pediatrics, Gunma Chuo Hospital, Japan.

Introduction: The relevant literature includes several case reports on cerebral infarction in children with HHV-6 infection; however, there is no report of brain stem infarction.

Case: An 11-month-old girl was hospitalized because of fever. She was unable to stand up and meet her mother's gaze. Read More

Biochem Biophys Res Commun 2017 05 22;486(3):706-711. Epub 2017 Mar 22.

Department of Virology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.

Human herpesvirus 6B (HHV-6B) causes exanthema subitum in infants and is known to be mildly pathogenic. However, HHV-6B infection can induce febrile seizures in a high percentage of patients, and in rare cases, result in encephalitis. We detected higher levels of interleukin (IL)-1β and basic fibroblast growth factor (bFGF) in the cerebrospinal fluid (CFS) of patients with HHV-6B encephalitis when compared to those in patients with non-HHV-6B-induced febrile seizures. Read More

J Med Virol 2017 04 27;89(4):696-702. Epub 2016 Sep 27.

Departments of Virology and Pediatrics, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

The amounts of the DNAs of human herpesviruses-6 (HHV-6) and -7 (HHV-7) in saliva samples were monitored during the acute and convalescent phases of exanthem subitum (ES) to elucidate the kinetics of virus shedding after ES. A total of 247 saliva samples were collected from 17 children (5 males and 12 females: 8-31 months old at onset). The monitoring period ranged from 152 to 721 days after onset, and in 15 children it was longer than 1 year. Read More

Pediatr Int 2016 May 29;58(5):415-417. Epub 2015 Dec 29.

Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.

Enterovirus focal encephalitis is a rare clinical entity that is characterized by focal neurological signs including seizure, hemiparesis, hemichorea, and headache, which are mainly followed by rapid spontaneous improvement. We herein describe the case of a 9-month-old boy who developed Coxsackie virus B5 (CVB5) focal encephalitis with seizure clusters in the eruption stage of roseola infantum-like illness, which were followed by rapid improvement and benign outcome. Lumbar puncture indicated pleocytosis, and CVB5 infection in the cerebrospinal fluid was subsequently identified on genome sequencing and virus isolation. Read More

Brain Dev 2015 Sep 9;37(8):829-32. Epub 2015 Jan 9.

Department of Pediatrics, Asahikawa Medical University, Asahikawa 078-8510, Japan.

Background: Human herpesvirus-6 (HHV-6) is the etiological agent of exanthema subitum-associated encephalopathy, which usually occurs in children younger than 3 years. Brain imaging shows various abnormalities.

Patient: A previously healthy 4-year-old girl developed acute encephalopathy with clinical features consisting of fever, repetitive seizures, and a disturbance of consciousness. Read More

Jundishapur J Microbiol 2014 Sep 1;7(9):e11821. Epub 2013 Sep 1.

Pediatrics Medical Center, Tehran University of Medical Sciences, Tehran, IR Iran.

Background: Encephalitis is swelling and inflammation of brain, usually due to viral infection. Viral encephalitis symptoms could be fever, headache, altered level of consciousness, and seizures.

Objectives: The aim of this study was detection of human herpesvirus-6 (HHV-6) DNA in cerebrospinal fluid (CSF) of patients with symptoms of possible acute encephalitis and without typical signs or symptoms of roseola infantum, using real-time polymerase chain reaction (PCR). Read More

Curr Opin Virol 2014 Dec 14;9:91-6. Epub 2014 Oct 14.

Division of Infectious Diseases, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 690, Rochester, NY 14642, USA. Electronic address:

The roseoloviruses, human herpesvirus-6A -6B and -7 (HHV-6A, HHV-6B and HHV-7) cause acute infection, establish latency, and in the case of HHV-6A and HHV-6B, whole virus can integrate into the host chromosome. Primary infection with HHV-6B occurs in nearly all children and was first linked to the clinical syndrome roseola infantum. However, roseolovirus infection results in a spectrum of clinical disease, ranging from asymptomatic infection to acute febrile illnesses with severe neurologic complications and accounts for a significant portion of healthcare utilization by young children. Read More

Pediatr Neurol 2014 Sep 13;51(3):448-52. Epub 2014 Apr 13.

Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan. Electronic address:

Background: Human herpesvirus 6 is a significant cause of the febrile illness roseola infantum in young children. Infection with human herpesvirus 6 typically causes a self-limited febrile illness but occasionally is associated with central nervous system manifestations, including febrile seizures and encephalitis. Host factors associated with severe manifestations of human herpesvirus 6-associated neurological disease remain poorly characterized. Read More

J Infect Chemother 2014 Nov 21;20(11):716-21. Epub 2014 Aug 21.

Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan.

Human herpesvirus-6 (HHV-6) is a cause of exanthema subitum and, sometimes, of febrile seizures. However, the pathogenesis of febrile seizures associated with HHV-6 infection remains unclear. We investigated serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) levels in infants with HHV-6 infection. Read More

Pediatr Int 2013 Apr 27;55(2):214-8. Epub 2013 Feb 27.

Department of Pediatrics, Cathay General Hospital, Taipei City, Taiwan.

Background: The aim of this study was to identify factors for differentiating roseola infantum from urinary tract infection (UTI) and to describe a cohort of infants diagnosed with roseola infantum and sterile pyuria.

Methods: The medical records of infants diagnosed with roseola infantum or UTI were examined. Multivariate analysis was performed to identify factors associated with UTI. Read More

Tohoku J Exp Med 2012 12;228(4):351-3

Department of Pediatrics, South Miyagi Medical Center, Ogawara, Japan.

Kawasaki Disease (KD) is acute, febrile, multisystem vasculitis of early childhood, the detailed mechanism of which is still unclear. Skin symptoms occur in KD, such as edema of the hands and feet with subsequent desquamation and redness at the inoculation site of bacillus Calmette-Guerin (BCG). The change at the BCG inoculation site has been considered as a specific feature of KD, although its mechanism is not fully understood. Read More

J Clin Microbiol 2012 Apr 25;50(4):1245-51. Epub 2012 Jan 25.

Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

In order to assess the full spectrum of human herpesvirus 6A (HHV-6A)- and HHV-6B-associated diseases, we sought to develop an HHV-6 species-specific serological assay based on immunoblot analysis. The immunodominant proteins encoded by open reading frame U11, p100 for HHV-6A (strain U1102) and 101K for HHV-6B (strain Z29), were selected to generate virus species-specific antigens. Recombinant p100 and 101K were produced in a prokaryotic expression system. Read More

Pediatr Neurol 2010 Apr;42(4):277-9

Department of Pediatrics, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Japan.

The aim of this study was to determine whether seizure susceptibility due to antihistamines is provoked in patients with febrile seizures. The study population comprised 14 patients with simple febrile seizures and 35 patients with complex febrile seizures. Detailed clinical manifestations were compared between patients with and without administration of antihistamine. Read More

Allergol Int 2010 Mar 25;59(1):83-6. Epub 2010 Nov 25.

Department of Pediatrics, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.

Background: Drug-induced hypersensitivity syndrome (DIHS) is a rare but severe disorder due to a systemic hypersensitivity reaction. We report on a case with DIHS-like symptoms following human herpes virus 6 (HHV-6) infection complicated with encephalopathy.

Case Summary: An 11-month-old girl suffered from a human herpes virus 6 (HHV-6) infection (exanthema subitum) complicated with encephalopathy. Read More

Pediatr Neurol 2009 Nov;41(5):353-8

Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

We sought to clarify clinical features of exanthem subitum associated-encephalitis/encephalopathy, generally caused by primary human herpesvirus-6 infection in Japan. A two-part questionnaire was sent to hospitals between January 2003-December 2004. Of 3357 questionnaires, 2357 (70. Read More

Arch Dis Child 2009 Sep 15;94(9):690-2. Epub 2009 Jun 15.

Department of Pediatrics, Assaf Harofeh Medical Center, Zerifin 70300, Israel.

Objective: To determine the aetiologies and clinical characteristics of infants with fever and a bulging fontanelle.

Design: The medical records of all febrile infants with a bulging fontanelle who underwent a lumbar puncture from January 2000 to February 2008 in Assaf Harofeh Medical Center, a university affiliated hospital in central Israel, were identified.

Results: 153 patients met the inclusion criteria. Read More

Pediatr Infect Dis J 2009 Mar;28(3):250-2

Third Department of Pediatrics, Athens University Medical School, Attikon University Hospital, Athens, Greece.

We describe the case of a 12-year-old boy with gloves and socks syndrome caused by coinfection with HHV-6 and PVB19, and review the published cases from 5 to 18 years of age to profile the disease in this age group. The review of the literature yielded 25 cases of gloves and socks syndrome. Most patients were febrile and had acute PVB19 infection. Read More

Brain Dev 2009 Nov 27;31(10):731-8. Epub 2008 Dec 27.

Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan.

Human herpesvirus-6 (HHV-6) is a causative agent of exanthema subitum. The immunological pathogenesis of acute encephalopathy associated with HHV-6 infection is still unclear. We measured the concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, IL-10, and soluble TNF receptor 1 (sTNFR1) in serum and cerebrospinal fluid (CSF) during the acute stage in 15 infants with acute encephalopathy and 12 with febrile seizures associated with HHV-6 infection. Read More

Neuropediatrics 2007 Oct;38(5):253-6

Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.

We found a DE NOVO missense mutation of the gene encoding the alpha1 subunit of the neuro-nal voltage-gated sodium channel, SCN1A, in a patient with repetitive focal seizures. At 5 months of age, the patient had a first seizure characterized by loss of consciousness and clonic convulsions in the left hand followed by secondary generalization lasting for 20 minutes in association with pyrexia. Although valproate was administered, she has had generalized seizures every month, mostly in association with elevated body temperature. Read More

J Child Neurol 2006 Oct;21(10):886-90

Department of Pediatrics, Kitasato University School of Medicine, Kanagawa, Japan.

Generally, West syndrome is an intractable epileptic syndrome in infancy, although spontaneous remission has been reported in some cases. An immunologic response to infection might be one of the factors involved in the remission of West syndrome, but the mechanisms remain unknown. On the other hand, exanthema subitum is a common disease occurring in infancy with the characteristics of fever and rash. Read More

Georgian Med News 2006 May(134):88-90

Research Institute of Pediatrics; REA Research and Rehabilitation Center, Tbilisi, Georgia.

Human herpesvirus 6 (HHV-6) is one of the recently discovered herpesviruses. Primary HHV-6 infection is a causative agent of roseola infantum and is frequently associated with nonspecific febrile seizures in children under the age of 3 years. The goal of our study was the investigation of HHV-6 infection in children with febrile seizures and to evaluate consequent seizures after the first episodes of febrile seizures associated vs. Read More

Nihon Rinsho 2006 Mar;64 Suppl 3:472-5

Department of Pediatrics, Banbuntanehotokukai Hospital, Fujita Health University.

J Neurol Neurosurg Psychiatry 2005 Dec;76(12):1723-5

Department of Paediatrics and Paediatric Neurology, Georg August University Goettingen, Robert-Koch-Str. 40, 37075 Goettingen, Germany.

Background: Baló's concentric sclerosis (BCS) is a demyelinating disorder believed to be a rare variant of multiple sclerosis (MS). Human herpesvirus 6 (HHV-6) is a highly neurotropic virus causing severe central nervous system (CNS) infections predominantly following reactivation of latent HHV-6 in immunocompromised individuals. Primary infection with HHV-6 usually occurs in early childhood manifesting as exanthema subitum. Read More

Brain Dev 2005 Oct;27(7):527-30

Department of Pediatrics, Kyoto Prefectural University of Medicine, Kawaramachi-Horikoji, Kamigyo, Kyoto 602-8566, Japan.

A 1-year-old female with acute bilateral striatal necrosis secondary to exanthema subitum associated with human herpesvirus 6 (HHV-6) infection is reported. The patient was previously healthy. She presented with progressive neurologic signs of oral dyskinesia and involuntary movements, after suffering from exanthema subitum. Read More

Nihon Rinsho 2005 Jul;63 Suppl 7:307-9

Department of Pediatrics, Fujita Health University, Banbuntanehotokukai Hospital.

N Engl J Med 2005 Feb;352(8):768-76

Department of Pediatrics, University of Washington, Seattle, USA.

Background: Serologic studies indicate that human herpesvirus 6 (HHV-6) infects 90 percent of children by two years of age. Little is known about the acquisition, virologic course, and clinical manifestations of HHV-6 infection.

Methods: We prospectively studied a cohort of 277 children from birth through the first two years of life to define the pattern of acquisition of HHV-6. Read More

Rinsho Shinkeigaku 2004 Nov;44(11):849-51

Department of Pediatrics, Fujita Health University School of Medicine.

Human herpesvirus-6 (HHV-6) is the causative agent of the common childhood infectious disease, exanthem subitum. Soon after the virus was isolated from humans it was found to be closely related to human cytomegalovirus, and thus was classified within the beta subgroup of human herpesviruses. HHV-6 possesses neuro-tropism in-vitro, and it has been suggested that primary infection can cause complications of the central nervous system (CNS), including febrile seizures and encephalitis/encephalopathy. Read More

No To Hattatsu 2004 Sep;36(5):385-90

Department of Pediatrics, Kumamoto Regional Medical Center, Kumamoto.

We report here a 1-year-old boy with human herpesvirus 6 (HHV 6) -associated encephalopathy. On the 3rd day of fever, he had a generalized tonic seizure followed by mild disturbance of consciousness, which recovered completely the next day. Two days later, he had skin rash of exanthema subitum, and his consciousness declined frequently. Read More

J Med Virol 2004 Nov;74(3):463-6

Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

A case of neonatal human herpesvirus 6 (HHV-6) B infection is presented. Although HHV-6 B was isolated from peripheral blood at the onset of the illness, a significant increase in viral antibody titers was not observed. The patient had a slight fever with generalized maculopapular skin rash and an increased number of atypical lymphocytes, which is quite different from the typical clinical features of exanthem subitum. Read More

Pediatr Int 2004 Aug;46(4):497-8

Department of Paediatrics, Urayasu-Ichikawa Shimin Hospital, Urayasu-shi, Japan.

Brain Dev 2004 Sep;26(6):377-9

Department of Pediatrics, St Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki 216-8511, Japan.

In general, epileptic seizures become more serious following infections. However, transient and permanent improvement of epileptic seizures has been observed following acute viral infections, without a recent change in anti-epileptic therapy. Questionnaires were sent to 73 institutions, throughout Japan, where pediatric neurologists care for children with epilepsy to characterize this phenomenon through clinician survey. Read More

Nihon Rinsho 2003 Feb;61 Suppl 2:185-9

Department of Pediatrics, Sapporo Medical University School of Medicine.

No To Hattatsu 2003 Jan;35(1):29-35

Department of Pediatrics, Osaka Police Hospital, Osaka.

Delirium in children associated with high fever is defined as an acute and transient confusional state. Clinically it is most important to differentiate delirium from encephalitis or encephalopathy. Electroencephalographic (EEG) tracings were obtained from 17 children with fever and delirium, consisting of 12 boys and 5 girls, aged from 2 to 13 years. Read More

Eur J Paediatr Neurol 2002 ;6(4):221-3

Department of Paediatrics, Otsu Red Cross Hospital, Otsu, Japan.

A 15-month-old girl developed frequent seizures at the eruptive stage of exanthema subitum. The eruption persisted for 2 weeks. Serum immunoglobulin G antibody to human herpes virus type 6 (HHV-6) increased markedly. Read More

Pediatr Infect Dis J 2002 Jun;21(6):569-70

Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

A female infant developed Guillain-Barré syndrome 20 days after having exanthem subitum confirmed serologically as human herpesvirus 6 infection. DNA of human herpesvirus 6 was detected in peripheral blood mononuclear cells collected on admission. Read More

J Pediatr Hematol Oncol 2002 Mar-Apr;24(3):211-4

Department of Pediatrics, Kanazawa National Hospital, Japan.

Purpose: To elucidate the mechanism underlying thrombocytopenia during the acute phase of exanthem subitum (ES), the associated hematological findings were investigated.

Patients And Methods: Five infants with thrombocytopenia during the acute phase of ES serologically confirmed by primary human herpesvirus-6 (HHV-6) were examined and followed-up.

Results: Thrombocytopenia was accompanied by neutropenia, leukopenia, and decreased reticulocyte fraction during the acute phase. Read More

Pediatr Int 2002 Jun;44(3):281-5

Division of Pediatrics,Toyonaka Municipal Hospital, Toyonaka, Osaka, Japan.

Background: Infants are usually protected from various viral infections, including human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7) infections, during the early infantile period by antibodies transferred from their mothers. However, rare cases of exanthem subitum (ES) in neonates have been described in published reports.

Methods: From the infantile patients of febrile illness, HHV-6 and HHV-7 DNA were examined by the polymerase chain reaction method. Read More

Curr Opin Infect Dis 2001 Jun;14(3):343-56

Department of Pediatrics, Division of Infectious Diseases, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23298, USA.

Fifth (erythema infectiosum) and sixth (roseola infantum) diseases are common rash illnesses of childhood that have long been recognized in clinical medicine. The discovery of the viruses that cause these illnesses has revealed relationships with other syndromes. Primary infection with the agent of erythema infectiosum, human parvovirus B19, is associated with transient aplastic crisis in hemolytic anemia, arthropathy in adults, chronic anemia in immunocompromised patients, and nonimmune fetal hydrops in pregnant women. Read More

Brain Dev 2001 Nov;23(7):705-7

Department of Pediatrics, Kyoto University School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. hhat2kuhp.kyoto-u.ac.jp

On a database of the Japanese medical literature between 1970 and 2000, there were 29 patients with West syndrome showing spontaneous remission. In 25/29 (86%) of the patients, spontaneous remission was preceded by viral infections, among which exanthema subitum predominated. In 16/29 (55%), the spasms recurred a median of 2 months later. Read More

J Clin Pathol 2001 Oct;54(10):792-5

Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

A 5 month old girl had typical clinical features of acute myocarditis just after the febrile period of exanthem subitum and died immediately. She had been healthy, with normal development, and there was no family history of particular note. Myocardial postmortem findings were compatible with acute myocarditis. Read More

Clin Infect Dis 2001 Sep 10;33(6):829-33. Epub 2001 Aug 10.

Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA.

The development of techniques for the culture of lymphoid cells and the isolation of viruses that infect these cells led to the discovery of human herpesvirus (HHV) 6 in 1986. At the time, HHV-6 was the first new human herpesvirus to be discovered in roughly a quarter of a century, and its isolation marked the beginning of an era of discovery in herpesvirology, with the identification of HHV-7 and HHV-8 (Kaposi's sarcoma-associated herpesvirus) during the following decade. Like most human herpesviruses, HHV-6 is ubiquitous and capable of establishing a lifelong, latent infection of its host. Read More

Pediatr Int 2001 Aug;43(4):372-8

Department of Pediatrics, Fujita Health University Hospital, Toyoake, Aichi, Japan.

Background: Quantitative analysis of human herpesvirus 6 (HHV-6) genome is important for monitoring active virus infection. The purpose of our study is to evaluate the reliability of a hybridization-based microtiter plate assay (polymerase chain reaction enzyme-linked immunosorbent assay (PCR ELISA)) for quantifying the virus genome.

Methods: Semiquantitative analysis of the virus genome was carried out in 31 (18 male and 13 female) infants with primary HHV-6 infection. Read More

AIDS Patient Care STDS 1998 Nov;12(11):833-42

Department of Pediatrics, University of Rochester School of Medicine and Dentistry, New York, USA.

Human herpesvirus-6 (HHV-6) and HHV-7 are newly recognized ubiquitous human viruses first discovered in patients with AIDS or lymphoproliferative disorders. Much more information is available about the clinical characteristics of infection with HHV-6 than HHV-7. Primary infection with HHV-6 occurs in early childhood and is most commonly manifested as an undifferentiated highly febrile illness, with seizures noted to be the most common complication. Read More

Pediatr Infect Dis J 2001 Apr;20(4):449-50

Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.

Placental transfer of maternal human herpesvirus (HHV) 6 and HHV 7 antibodies to infants was examined simultaneously in 69 paired plasma samples by an indirect immunofluorescence assay. All the mothers had antibodies to both viruses. The mean HHV 6 and HHV 7 antibody titers of infants were significantly higher than those of the mothers. Read More

Pediatr Int 2000 Dec;42(6):631-6

Department of Pediatrics, Mie University School of Medicine, Japan.

Background: Human Herpes virus 6 (HHV-6) is a causative agent of exanthema subitum and replicates mainly in lymphocytes. The aim of present study was to investigate cytotoxicity against HHV-6-infected cells by cord blood mononuclear cells (CBMC) and adult peripheral blood mononuclear cells (PBMC).

Methods: Human herpes virus 6-infected and -uninfected lymphocytes were used as target cells. Read More

Brain Dev 2000 Aug;22(5):307-14

Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

Human herpesvirus-6 (HHV-6) is the causative agent of the common childhood infectious disease, exanthem subitum. After the virus was recently isolated from humans, it was found to be closely related to human cytomegalovirus (CMV), and was thus classified within the beta subgroup of human herpesviruses. HHV-6 possesses neurotropism in vitro, and it has been suggested that primary infection can cause complications of the central nervous system (CNS), including febrile seizures and encephalitis/encephalopathy. Read More