452,330 results match your criteria Pediatrics Respiratory Distress Syndrome


Early-Stage Translational Research in Perinatal Medicine.

Neonatology 2018 Dec 6;115(2):182-188. Epub 2018 Dec 6.

Liggins Institute, University of Auckland, Auckland, New

Background: Pre-clinical research, which encompasses studies in animals and in the laboratory, has made significant contributions to the improvement of neonatal outcomes.

Methods: Here, we describe examples of how pre-clinical research can be the starting point on the journey to the development of new interventions to improve neonatal care and outcomes and discuss recent progress in ensuring methodological and ethical rigour in pre-clinical research involving animal models.

Results: Studies in pregnant sheep led to the serendipitous discovery that preterm lambs born after exogenous corticosteroid exposure were able to aerate their lungs. Read More

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December 2018
5 Reads

High Circulating Alarin Levels Are Associated with Presence of Metabolic Syndrome.

Cell Physiol Biochem 2018 Dec 6;51(5):2041-2051. Epub 2018 Dec 6.

Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University and Chongqing Clinical Research Center for Geriatrics, Chongqing,

Background/aims: Alarin has been reported to be related with increased food intake and body weight. The relationship of circulating Alarin with insulin resistance or metabolic syndrome (MetS), however, is unknown. This study aimed to investigate the physiological role of Alarin and its association with MetS in humans. Read More

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December 2018
1 Read

Behavioral problems are associated with cognitive and language scores in toddlers born extremely preterm.

Early Hum Dev 2018 Dec 3;128:48-54. Epub 2018 Dec 3.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Objective: To evaluate the relationship of parent-reported child behaviors on the Child Behavior Checklist (CBCL) to cognition, language, and motor skills on the Bayley Scales of Infant and Toddler Development - III (Bayley-III) in toddlers born extremely preterm.

Study Design: Toddlers born extremely preterm (gestational ages 22 0/7 to 26 6/7 weeks) were tested at 22-26 months corrected age with Bayley-III while parents completed the CBCL. Socio-demographic variables and medical history were recorded. Read More

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December 2018
3 Reads

A systematic review of sudden unexpected death in epilepsy (SUDEP) in childhood.

Epilepsy Behav 2018 Dec 3;90:99-106. Epub 2018 Dec 3.

Population, Policy and Practice Unit, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

Background: Sudden Unexpected Death in Epilepsy (SUDEP) is a significant cause of death in childhood epilepsy, and causes considerable concern to patients and their families. Despite this, the condition remains poorly understood. This systematic review investigates the risk factors, pathophysiology, and circumstances associated with childhood SUDEP. Read More

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December 2018
12 Reads

Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells.

Neoplasia 2018 Dec 3;21(1):74-81. Epub 2018 Dec 3.

Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Frankfurt, Germany; German Cancer Consortium (DKTK), Partner Site, Frankfurt, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

Interferons (IFNs) are key players in the tumor immune response and act by inducing the expression of IFN-stimulated genes (ISGs). Here, we identify the mixed-lineage kinase domain-like pseudokinase (MLKL) as an ISG in various cancer cell lines. Both type I and type II IFNs increase the expression of MLKL indicating that MLKL up-regulation is a general feature of IFN signaling. Read More

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December 2018
2 Reads

Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.

Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Non-graft-versus-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. Read More

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December 2018
5 Reads

Are environmental factors for atopic eczema in ISAAC Phase Three due to reverse causation?

J Invest Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Department of Paediatrics, Prince of Wales Hospital, Hong Kong, SAR China.

Some previously described environmental associations for atopic eczema (AE) may be due to reverse causation. We explored the role of reverse causation by comparing individual- and school-level results for multiple AE risk factors. ISAAC Phase Three surveyed children within schools (the sampling unit) on AE symptoms and potential risk factors. Read More

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December 2018
2 Reads

Identification and Modulation of Microenvironment is Crucial for Effective MSC Therapy in Acute Lung Injury.

Am J Respir Crit Care Med 2018 Dec 6. Epub 2018 Dec 6.

The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, Critical Care Medicine, Guangzhou, Guangdong, China.

Rationale: There are controversial reports on applications of mesenchymal stromal cells (MSCs) in patients with acute respiratory distress syndrome (ARDS).

Objective: We hypothesized that lung microenvironment was the main determinant of beneficial versus detrimental effects of MSCs during ARDS.

Methods: Lung proteome was profiled in three models of injury induced by acid instillation and/or mechanical ventilation in mice. Read More

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December 2018
2 Reads

Vaccines for preventing invasive salmonella infections in people with sickle cell disease.

Cochrane Database Syst Rev 2018 Dec 5;12:CD006975. Epub 2018 Dec 5.

Department of Paediatrics, University of Calabar Teaching Hospital, PMB 1115, Calabar, Cross River State, Nigeria, 540261.

Background: Salmonella infections are a common bacterial cause of invasive disease in people with sickle cell disease especially children, and are associated with high morbidity and mortality rates. Although available in some centres, people with sickle cell anaemia are not routinely immunized with salmonella vaccines. This is an update of a previously published Cochrane Review. Read More

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December 2018
4 Reads

Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury.

PLoS One 2018 6;13(12):e0208426. Epub 2018 Dec 6.

Division of Vascular Surgery, Northwestern University, Chicago, IL, United States of America.

Background: The microbiome has a functional role in a number of inflammatory processes and disease states. While neointimal hyperplasia development has been linked to inflammation, a direct role of the microbiota in neointimal hyperplasia has not yet been established. Germ-free (GF) mice are an invaluable model for studying causative links between commensal organisms and the host. Read More

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December 2018
3 Reads

Plasma donor-derived cell-free DNA kinetics after kidney transplantation using a single tube multiplex PCR assay.

PLoS One 2018 6;13(12):e0208207. Epub 2018 Dec 6.

Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.

Background: After transplantation, cell-free DNA derived from the donor organ (ddcfDNA) can be detected in the recipient's circulation. We aimed to quantify ddcfDNA levels in plasma of kidney transplant recipients thereby investigating the kinetics of this biomarker after transplantation and determining biological variables that influence ddcfDNA kinetics in stable and non-stable patients.

Materials And Methods: From 107 kidney transplant recipients, plasma samples were collected longitudinally after transplantation (day 1-3 months) within a multicenter set-up. Read More

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December 2018

Tissue Specificity in Trisomy 22 Mosaicism: A Tale of Caution for Interpretation of Chromosomal Microarray Results.

J Assoc Genet Technol 2018 ;44(4):137-140

Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT.

Objectives: While the complete form of trisomy 22 is seemingly incompatible with life, the mosaic form is a rare syndrome associated with developmental delays, intellectual disability, and dysmorphic features. Due in part to the difficulty of analyzing chromosomal mosaicism, many instances either go undiagnosed or have their diagnosis delayed. We report a case of mosaic trisomy 22 in a diamnionic-dichorionic twin with marked growth discordance and intra-uterine growth restriction, diagnosed in a 2-year-old with developmental delays, sensorineural hearing loss, cardiac and gastrointestinal abnormalities, and osteopenia of prematurity. Read More

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January 2018
6 Reads

Effects of Zinc Combined with Probiotics on Antibiotic-associated Diarrhea Secondary to Childhood Pneumonia.

J Trop Pediatr 2018 Dec 6. Epub 2018 Dec 6.

Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning city, 530021 China.

Aim: The aim of this study was to evaluate the impact of zinc combined with probiotics (Bifico) on antibiotic-associated diarrhea (AAD) secondary to pneumonia.

Methods: A total of 50 patients with AAD secondary to pneumonia were randomly divided into a probiotics group (Bifico) and a combined group (zinc combined with Bifico) and 25 pneumonia patients without AAD as the control group. Serum levels of zinc, diamine oxidase (DAO) activity, D-lactate and intestinal flora [Bifidobacterium, Escherichia coli and Bifidobacterium/E. Read More

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December 2018

Pediatric Office Delivery of Smoking Cessation Assistance for Breast-Feeding Mothers.

Nicotine Tob Res 2018 Dec 6. Epub 2018 Dec 6.

Division of General Academic Pediatrics, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA.

Introduction: National and international organizations have done an excellent job of advocating and promoting breast feeding for all mothers. This study assessed to what extent an intervention increased delivery of cessation assistance to breast-feeding mothers who smoke.

Methods: Data were collected between April and October 2015 in five US states as part of a cluster randomized controlled trial in 10 pediatric practices. Read More

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December 2018
2 Reads

Impact of HLA allele-KIR pairs on HIV clinical outcome in South Africa.

J Infect Dis 2018 Dec 6. Epub 2018 Dec 6.

Department of Paediatrics, University of Oxford, Oxford, United Kingdom.

Background: HLA class I contributes to HIV immune control through antigen presentation to both cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. However, by contrast with investigations of CTL, studies of NK cells in HIV control through HLA-killer immunoglobulin-like receptor (KIR) interactions remain sparse in African cohorts.

Methods: 312 treatment naïve, chronically HIV-infected adults were recruited from South Africa, and the effects of HLA-KIR pairs on clinical outcome were statistically analyzed. Read More

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December 2018
1 Read

One More Chasm to Cross for Telemedicine in the ICU?

Pediatr Crit Care Med 2018 Dec;19(12):1180-1181

Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH Center for Telehealth, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

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December 2018
1 Read

Tranexamic Acid and Seizures in Pediatric Trauma.

Pediatr Crit Care Med 2018 Dec;19(12):1177-1178

Department of Pediatrics, Sections of Pediatric Critical Care and Pediatric Hematology, Oncology and Bone Marrow Transplantation, University of Colorado School of Medicine, Aurora, CO Division of Pediatric Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, CO Section of Pediatric Critical Care, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.

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December 2018
1 Read

PICU Autopsies: Every One Is Important.

Pediatr Crit Care Med 2018 Dec;19(12):1173-1174

Division of Pediatric Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, OH.

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December 2018
1 Read

Evaluating the Impact of Delaying Parenteral Nutrition in Critically Ill Children.

Authors:
Walter J Chwals

Pediatr Crit Care Med 2018 Dec;19(12):1169-1172

Departments of Surgery and Pediatrics, Tufts University School of Medicine, Boston, MA.

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December 2018
1 Read

To PICC or Not to PICC, That Is the Question!

Pediatr Crit Care Med 2018 Dec;19(12):1168-1169

Departments of Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA.

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December 2018
1 Read

Comparing Vasoactive-Inotropic Score Reporting Strategies in the PICU Relative to Mortality Risk.

Pediatr Crit Care Med 2018 Dec;19(12):1130-1136

All authors: Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX.

Objectives: High Vasoactive-Inotropic Scores have demonstrated association with poor outcomes in pediatric cardiac ICUs and are being calculated more frequently in studies of critically ill noncardiac patients. Available studies differ in their approach to assigning Vasoactive-Inotropic Scores, making direct comparisons difficult. The goal of this investigation is to compare multiple approaches to Vasoactive-Inotropic Score assignment to determine their strength of association with mortality in a general pediatric intensive care population. Read More

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December 2018
2 Reads

Role of Prices, Utilization, and Health in Explaining Texas Medicaid Newborn Care Spending Variation.

Med Care 2018 Dec 4. Epub 2018 Dec 4.

Department of Health Services Administration, University of Maryland School of Public Health, College Park, MD.

Background: Newborn care is one of the most frequent types of hospitalization and Medicaid covers over 50% of all births nationwide. However, little is known about regional variation in Medicaid newborn care spending and its drivers.

Objectives: To measure the contribution of market-level prices, utilization, and health risk on regional variation in spending among newborn Medicaid population in Texas. Read More

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December 2018

Inpatients Sign On: An Opportunity to Engage Hospitalized Patients and Caregivers Using Inpatient Portals.

Med Care 2018 Dec 4. Epub 2018 Dec 4.

Department of Pediatrics, University of Wisconsin School of Medicine and Public Health.

Background: Inpatient portals are online patient portals linked to electronic health records that provide hospitalized patients and caregivers secure access to real-time clinical information and tools to enhance their communication with providers and hospital experience.

Objective: The main objective of this commentary was to provide a perspective that inpatient portals are innovative tools poised to engage patients and caregivers during hospitalization and, thus, enhance patient-centered care.

Results: Inpatient portals are desired by patients and caregivers and may contribute to improved recognition of their inpatient care team, knowledge of their treatment plan and overall inpatient experience. Read More

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December 2018

Novel NTRK3 Fusions in Fibrosarcomas of Adults.

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Rare Cancer Center.

NTRK fusions in malignant tumors are therapeutic targets of tyrosine kinase inhibitors. Because they occur only in a small subset of mesenchymal tumors, knowledge regarding the corresponding histology is important to effectively identify patients who could benefit from targeted therapy. In this study, using RNA sequencing, we identified novel NTRK3 fusions involving related partner genes in 2 adult bone and soft tissue tumors that met the current histologic criteria of fibrosarcoma. Read More

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December 2018
3 Reads

Do Mindfulness and Self-Compassion Predict Burnout in Pediatric Residents?

Acad Med 2018 Dec 4. Epub 2018 Dec 4.

K.J. Kemper is founding director, Center for Integrative Health and Wellness and professor of pediatrics, The Ohio State University, Columbus, Ohio. H. McClafferty is director, Pediatric Integrative Medicine in Residency Program and co-director, the Fellowship in Integrative Medicine, The University of Arizona Center for Integrative Medicine, The University of Arizona College of Medicine, Tucson, Arizona. P.M. Wilson is assistant professor, Division of Emergency Medicine, Children's Hospital of Pittsburgh and the University of Pittsburgh, Pittsburgh, Pennsylvania. J.R. Serwint is professor emeritus of pediatrics, Johns Hopkins University, Baltimore, Maryland. M. Batra is associate program director, Pediatric Residency Program and associate professor of pediatrics, Seattle Children's Hospital and the University of Washington in Seattle, Washington. J.D. Mahan is director, Pediatric Residency Program and professor of pediatrics, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio. C.J. Schubert is professor of pediatrics, Cincinnati Children's Hospital Medical Center and The University of Cincinnati, Cincinnati, Ohio. B.B. Staples is director, Pediatric Residency Program and associate professor of pediatrics, Duke University Medical Center, Durham, North Carolina. A. Schwartz is Michael Reese Endowed Professor of Medical Education and director of research, University of Illinois College of Medicine, Chicago, Illinois, and data analyst, Association of Pediatric Program Directors Longitudinal Educational Assessment Research Network.

Purpose: Burnout symptoms are common among health professionals. Gaps remain in understanding both the stability of burnout and compassion over time and relationships among burnout, self-compassion, stress, and mindfulness in pediatric residents.

Method: The authors conducted a prospective cohort study of residents at 31 U. Read More

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December 2018
7 Reads

High-Value Interviewing: A Call for Quality Improvement in the Match Process.

Acad Med 2018 Dec 4. Epub 2018 Dec 4.

B. Frush is a first-year resident in internal medicine-pediatrics, Vanderbilt University Medical Center and Monroe Carell Jr Children's Hospital at Vanderbilt, Nashville, Tennessee. The author was a fourth-year medical student, University of North Carolina School of Medicine, Chapel Hill, North Carolina, at the time of writing. J. Byerley is professor of pediatrics, vice dean for education, and chief education officer, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

Within the Match process, current residency interview practices are inefficient for both applicants and programs. Problems include disorganized interview offers and scheduling, excessive numbers of applicant interviews, unclear postinterview communication policies, and the significant expenses entailed. To address these issues, the authors propose applying a quality improvement approach to create a high-value interview process that would decrease investments of time, money, and energy and improve the quality of the Match experience for both applicants and programs. Read More

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December 2018
1 Read

Using Simulation to Teach Echocardiography: A Systematic Review.

Simul Healthc 2018 Dec;13(6):413-419

From the Department of Medicine, University of Florida, College of Medicine (C.A.R., J.M.M.), University of Florida Health Science Center Libraries (H.F.N.); Division of Medical Education, Department of Pediatrics (E.B.), Division of Cardiovascular Medicine, Department of Medicine (D.E.W.), University of Florida, College of Medicine, Gainesville, FL.

Statement: We identified 24 studies of high-fidelity simulation being used to teach echocardiography. A variety of study designs were used with outcomes ranging from reports of learner self-confidence up to improvement in organizational practice. Most studies were carried out in graduate medical populations, specifically in anesthesia trainees. Read More

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December 2018

Partial Deletion of Tie2 Affects Microvascular Endothelial Responses to Critical Illness in a Vascular Bed and Organ-Specific Way.

Shock 2018 Jul 30. Epub 2018 Jul 30.

Department of Pathology and Medical Biology, Medical Biology section.

Tie2 is a tyrosine kinase receptor that is mainly expressed by endothelial cells. In animal models mimicking critical illness, Tie2 levels in organs are temporarily reduced. Functional consequences of these reduced Tie2 levels on microvascular endothelial behaviour are unknown. Read More

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July 2018
3 Reads

Childhood Hearing Loss in Patients With Sickle Cell Disease in the United States.

J Pediatr Hematol Oncol 2018 Dec 4. Epub 2018 Dec 4.

Departments of Otolaryngology-Head and Neck Surgery.

This study sought to examine if modern medical evaluations including newborn screening and early diagnosis along with better methods of disease control have improved rates of hearing loss in children with sickle cell disease (SCD). Audiometric and medical data for patients with SCD was obtained from the AudGen Database and analyzed for the presence of hearing loss, type of hearing loss, severity of hearing loss, and correlation with comorbid conditions. Children with sickle cell trait (SCT) were used as a comparison group. Read More

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December 2018

Thrombospondin-1 and Vitamin D in Children With Sickle Cell Anemia.

J Pediatr Hematol Oncol 2018 Dec 4. Epub 2018 Dec 4.

Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait.

Background: Thrombospondin-1 (TSP-1) and 25-hydroxyvitamin D (25-OHD) play significant roles in the pathogenesis of sickle cell anemia (SCA). TSP-1 enhances cellular adhesion/inflammation, hence contributing to vaso-occlusive crisis (VOC); vitamin D, in contrast, retards inflammation and may lower rate of pain episodes. We determined serum levels of TSP-1 and 25-OHD in Nigerian children with SCA and their matched hemoglobin AA controls; and assess the relationship between the 2 biomarkers. Read More

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December 2018
1 Read

Surgical Overlap: An Ethical Approach to Empirical Ambiguity.

Int Anesthesiol Clin 2019 ;57(1):18-31

Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

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January 2019
2 Reads

Transient Q-waves in an infant with asymptomatic myocardial infarction due to Kawasaki disease.

Cardiol Young 2018 Dec 6:1-4. Epub 2018 Dec 6.

Department of Pediatrics,Shinshu University School of Medicine,Asahi 3-1-1, Matsumoto,Japan.

Giant coronary artery aneurysms are a complication of Kawasaki disease and can be fatal if associated with thrombosis. We describe the clinical outcome of a boy with Kawasaki disease who exhibited "supergiant" coronary artery aneurysms at the age of 14 months and, despite treatment with anticoagulant and antiplatelet medication, developed a left coronary artery thrombosis and presented following a myocardial infarction at 2 years old. Although his symptoms were minimal, the myocardial infarction was identified by abnormal Q-waves and giant negative T-waves in precordial leads of routine electrocardiography. Read More

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December 2018
1 Read

RNA regulons are essential in intestinal homeostasis.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 6. Epub 2018 Dec 6.

Pediatrics, GI Division, Children's Hospital of Philadelphia, United States.

Intestinal epithelial cells are among the most rapidly proliferating cell types in the human body. There are several different sub-types of epithelial cells, each with unique functional roles in responding to the ever-changing environment. The epithelium's ability for rapid and customized responses to environmental changes requires multi-tiered levels of gene regulation. Read More

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December 2018

Biallelic loss of function variants in PPP1R21 cause a neurodevelopmental syndrome with impaired endocytic function.

Hum Mutat 2018 Dec 6. Epub 2018 Dec 6.

Genome Research Division, Human Genetics department, Radboud University Medical Center Nijmegen and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.

Next-generation sequencing has been instrumental in solving the genetic basis of rare inherited diseases, especially neurodevelopmental syndromes. However, functional workup is essential for precise phenotype definition and to understand the underlying disease mechanisms. Using whole exome and whole genome sequencing in 4 independent families with hypotonia, neurodevelopmental delay, facial dysmorphism, loss of white matter and thinning of the corpus callosum, we identified 4 previously unreported homozygous truncating PPP1R21 alleles: c. Read More

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December 2018

Solving for X: Evidence for sex-specific autism biomarkers across multiple transcriptomic studies.

Am J Med Genet B Neuropsychiatr Genet 2018 Dec 6. Epub 2018 Dec 6.

Centre for Pattern Recognition and Data Analytics (PRaDA), Deakin University, Geelong, Australia.

Autism spectrum disorder (ASD) is a markedly heterogeneous condition with a varied phenotypic presentation. Its high concordance among siblings, as well as its clear association with specific genetic disorders, both point to a strong genetic etiology. However, the molecular basis of ASD is still poorly understood, although recent studies point to the existence of sex-specific ASD pathophysiologies and biomarkers. Read More

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December 2018
1 Read

Comment on: Factors affecting quality of life in children and adolescents with thalassemia in Iraqi Kurdistan.

Saudi Med J 2018 Dec;39(12):1263-1264

Department of Pediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq. E-mail.

[No Abstract Available]. Read More

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December 2018

Safety of Sports for Young Patients With Implantable Cardioverter-Defibrillators.

Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006305

Yale University School of Medicine, New Haven, CT (J.D., C.B., L.S., F.L., R.J.L.).

Background: Despite safety concerns, many young patients with implantable cardioverter-defibrillators (ICDs) participate in sports. We undertook a prospective, multinational registry to determine the incidence of serious adverse events because of sports participation. The primary end points were death or resuscitated arrest during sports or injury during sports because of arrhythmia or shock. Read More

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November 2018
1 Read

Prolonged clonazepam-induced withdrawal symptoms in an NAT2 ultraslow acetylator.

Pharmacogenomics 2018 Dec 6. Epub 2018 Dec 6.

Department of Pediatrics, USF Health South Tampa Center for Advanced Healthcare, Tampa, FL 33606, USA.

Clonazepam undergoes nitroreduction to 7-amino-clonazepam via CYP3A4/5, followed by acetylation to 7-acetamido-clonazepam via N-acetyltransferase-2 (NAT2) enzyme. While no pharmacological activity is attributed to the metabolites of clonazepam, 7-amino-clonazepam has some affinity for the benzodiazepine receptor as a partial agonist for the gamma aminobutyric acid-A receptor and can compete with clonazepam. Interindividual variability in the incidence of adverse events in patients may, in part, be attributable to differences in clonazepam metabolism. Read More

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December 2018
1 Read

An Assessment of the Paediatric Internship at University Hospital Limerick over a 30 Month Period

Ir Med J 2018 08 13;111(7):796. Epub 2018 Aug 13.

Department of Paediatrics, University Hospital Limerick (UHL), Limerick.

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Emergency Admissions of Children and Young People with Mental Health Needs to the Paediatric Ward

Ir Med J 2018 08 13;111(7):795. Epub 2018 Aug 13.

Department of Paediatrics, Wexford General Hospital, Ireland

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Advances in Management of Neonatal Abstinence Syndrome: What’s the score?

Ir Med J 2018 08 13;111(7):785. Epub 2018 Aug 13.

Department of Paediatrics, Midland Regional Hospital, Mullingar, Co. Westmeath

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August 2018
1 Read

Peripheral White Blood Cell Differential Counts In Children With UTI, Is There A Link?

Ir Med J 2018 06 7;111(6):780. Epub 2018 Jun 7.

Department of Paediatrics, NCH, Tallaght, Dublin 24

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June 2018
1 Read

Introduction of an Oral Fluid Challenge Protocol in the Management of Children with Acute Gastroenteritis: A Regional Hospital Experience.

Ir Med J 2018 06 7;111(6):775. Epub 2018 Jun 7.

Academic Department of Paediatrics, National University of Ireland, Galway, Ireland

Oral rehydration therapy (ORT) remains the ideal first line therapy for acute gastroenteritis (AGE). Our aim was to assess the impact of introducing an Oral Fluid Challenge (OFC) protocol on outcomes such as intravenous fluid use and documentation in our institution. A single centre study with data collected retrospectively pre-implementation (April 2015) of the OFC protocol and post implementation (April 2016). Read More

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Outcomes following neonatal portal vein thrombosis: A descriptive, single-center study and review of anticoagulant therapy.

Pediatr Blood Cancer 2018 Dec 5:e27572. Epub 2018 Dec 5.

Division of Neonatology, Department of Pediatrics, McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada.

Background: Neonatal portal vein thrombosis (PVT) is uncommon with potentially serious complications that may manifest in infancy and childhood.

Objective: The primary aim of our study was to describe the short-term and long-term outcomes of neonatal PVT.

Methods: A retrospective chart review was conducted from 2008 to 2016 of neonates diagnosed with PVT. Read More

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December 2018

A novel model for predicting non-responsiveness to intravenous immunoglobulins in Kawasaki disease: The Singapore experience.

J Paediatr Child Health 2018 Dec 5. Epub 2018 Dec 5.

Division of Paediatric Cardiology, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore.

Aim: We aimed to assess the utility of four published risk-scoring methods in predicting intravenous immunoglobulins (IVIG) non-responsiveness in Kawasaki disease (KD) patients from Singapore and develop a new predictive model.

Methods: We reviewed the medical records of 215 KD children. The performance of existing scoring methods in identifying non-responsive cases based on sensitivities (SN) and specificities (SP) was evaluated in 122 Singaporean Chinese. Read More

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December 2018
1 Read

A core outcome set for the evaluation of treatments for twin-twin transfusion syndrome.

Ultrasound Obstet Gynecol 2018 Dec 6. Epub 2018 Dec 6.

Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, Cranmer Terrace, London SW17 0RE, United Kingdom.

Background: A minimum data set, known as a core outcome set, should standardise outcome selection, collection, and reporting across future twin-to-twin transfusion syndrome research.

Methods: An international steering group including healthcare professionals, researchers, and patients, guided the development of this core outcome set. Potential core outcomes, identified through a comprehensive literature review, were entered into a three round Delphi survey. Read More

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December 2018
1 Read

Reply to a correspondence addressing the European guideline for treatment of atopic eczema, functional textiles and the CLOTHES trial.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

Department Dermatology and Allergy Biederstein, Technische Universität München Munich, Germany and Christine Kühne-Center for Allergy Research and Education (CK-CARE)Davos.

We have read with interest the respectfully written correspondence by Wüthrich et al. regarding antimicrobial silk textiles for atopic dermatitis (AD) (1). Though it was submitted as a comment to the European consensus-based S2k guidelines on treatment of atopic eczema (2,3), it is discussing in 70% of its length the CLOTHES trial - published in two non-JEADV-publications which we have neither designed nor authored (4,5). Read More

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December 2018
2 Reads