1,988 results match your criteria Pediatrics Pertussis


Postvaccination Fever Response Rates in Children Derived Using the Fever Coach Mobile App: A Retrospective Observational Study.

JMIR Mhealth Uhealth 2019 Apr 22;7(4):e12223. Epub 2019 Apr 22.

Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Postvaccination fever is a mild adverse event that naturally improves without complications, but is highly prevalent and can be accompanied by febrile convulsions in some cases. These adverse effects may cause parents to delay or avoid vaccinating their children.

Objective: This study aimed to identify postvaccination fever patterns and the ability of antipyretics to affect changes in these patterns from data collected from a mobile app named Fever Coach. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2196/12223DOI Listing

Respiratory Viruses Frequently Mimic Pertussis in Young Infants.

Pediatr Infect Dis J 2019 May;38(5):e107-e109

Clinical Microbiology Laboratory, Bnai Zion Medical Center, Haifa, Israel.

Bordetella pertussis is prevalent among infants, but its diagnosis is complicated by the fact that its signs and symptoms overlap with respiratory viruses. Indeed, when evaluating the etiology of infants less than 1 year of age suspected of having pertussis, we found that respiratory viruses frequently mimic B. pertussis and are more likely to be the causative agent. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00006454-201905000-0002
Publisher Site
http://dx.doi.org/10.1097/INF.0000000000002223DOI Listing
May 2019
1 Read

Tubercular Abscess near Diphtheria-Pertussis-Tetanus Injection Site: A Rare Complication of Immunization.

Indian J Community Med 2019 Jan-Mar;44(1):64-65

Department of General surgery, A.N. Magadh Medical College, Gaya, Bihar, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijcm.IJCM_220_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437798PMC
April 2019
1 Read

Bacteremia: Clinical Expression and Bacterial Genomics.

Open Forum Infect Dis 2019 Apr 7;6(4):ofz122. Epub 2019 Mar 7.

Institut Pasteur, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France.

Whooping cough's primary etiological agent is . The closely related rarely causes severe disease. Here we report an unusual case of bacteremia caused by , review the literature, and characterize the genomic sequence of the bacterial isolate in comparison with isolates from respiratory infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ofid/ofz122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453521PMC
April 2019
1 Read

Acquisition of specific antibodies and their influence on cell-mediated immune response in neonatal cord blood after maternal pertussis vaccination during pregnancy.

Vaccine 2019 May 5;37(19):2569-2579. Epub 2019 Apr 5.

Laboratory of Medical Investigation (LIM-36), Department of Pediatrics, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Maternal immunization with pertussis acellular vaccine (Tdap) is an intervention that provides protection to newborns. However, it has been reported that high maternal antibody levels may adversely affect the immune response of infants after active immunization. In this study, we evaluated neonatal passive acquisition of pertussis-specific antibodies and their influence on the neonatal cell-mediated immune response. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2019.03.070DOI Listing
May 2019
1 Read

Adolescent vaccinations: updates for the general practitioner.

Curr Opin Pediatr 2019 Apr 1. Epub 2019 Apr 1.

Department of Pediatrics, University of Massachusetts Medical School-Baystate, Springfield, Massachusetts, USA.

Purpose Of Review: Adolescent providers have a unique opportunity to interface with adolescents during a transformative time period. Optimizing vaccinations may protect teens against preventable but potentially deadly diseases. Healthcare providers must be aware of the evolving vaccination data and up-to-date recommendations for vaccinations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOP.0000000000000759DOI Listing
April 2019
3 Reads

Maternal pertussis vaccination and its effects on the immune response of infants aged up to 12 months in the Netherlands: an open-label, parallel, randomised controlled trial.

Lancet Infect Dis 2019 Apr 27;19(4):392-401. Epub 2019 Mar 27.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands. Electronic address:

Background: Maternal tetanus, diphtheria, and acellular pertussis (Tdap) vaccination offers protection for neonates against clinical pertussis until primary vaccinations, but maternal antibodies also interfere with infants' immune responses to primary vaccinations. We investigated the effect of maternal Tdap vaccination on the pertussis antibody responses of infants starting primary vaccinations at age 3 months.

Methods: In an open-label, parallel, randomised, controlled trial, pregnant women aged 18-40 years with a low risk of pregnancy complications were recruited through independent midwives at 36 midwife clinics in the Netherlands and received Tdap vaccination either at 30-32 weeks of pregnancy (maternal Tdap group) or within 48 h after delivery (control group). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1473-3099(18)30717-5DOI Listing
April 2019
3 Reads

Age-related differences in antibody avidities to pertussis toxin and filamentous hemagglutinin in a healthy Japanese population.

Vaccine 2019 Apr 28;37(18):2463-2469. Epub 2019 Mar 28.

Department of Bacteriology II, National Institute of Infectious Diseases, Japan. Electronic address:

To gain insights into the current Japanese pertussis immunization schedule, we examined the distributions of antibody titers and avidities to pertussis toxin (PT) and filamentous hemagglutinin (FHA) in 460 Japanese healthy subjects (aged 1-60 years) based on age category. Our avidity enzyme-linked immunosorbent assays revealed that young children aged 1-2 years, which corresponded to ages after receiving primary and/or booster pertussis vaccinations, had relatively high-avidity anti-PT IgG (mean avidity index [AI], 40.5%) compared with other age groups (AI, 26. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2019.03.055DOI Listing

Maternal Immunization.

Obstet Gynecol 2019 Apr;133(4):739-753

Department of Pediatrics, Baylor College of Medicine, Houston, Texas; and the Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.

Vaccines administered to women during pregnancy can provide protection against serious infectious diseases for the mother, for the newborn, or both. Maternal immunization boosts the concentration of maternal antibodies that can be transferred across the placenta to directly protect infants too young to be immunized. In addition, indirect protection through prevention of maternal infection and through breast milk antibodies can be achieved through maternal immunization. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/AOG.0000000000003161DOI Listing
April 2019
3 Reads

[Antimicrobial susceptibility and antigen genotypes of Bordetella pertussis strains isolated from neonates].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Mar;21(3):208-213

National Center for Children's Health/Beijing Children's Hospital, Capital Medical University/Beijing Pediatric Research Institute/National Key Discipline of Pediatrics (Capital Medical University)/National Clinical Research Center for Respiratory Diseases/Key Laboratory of Major Diseases in Children, Ministry of Education/Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing 100045, China.

Objective: To investigate the alternative antimicrobial drugs for the treatment of neonatal pertussis and the antigen genotypes of Bordetella pertussis (B. pertussis) strains.

Methods: A total of 32 B. Read More

View Article

Download full-text PDF

Source

Effects of sex and birth weight on non-specific health services use following whole-cell pertussis vaccination: a self-controlled case series analysis.

Hum Vaccin Immunother 2019 Mar 4:1-6. Epub 2019 Mar 4.

a Clinical Epidemiology Program , Ottawa Hospital Research Institute , Ottawa , Ontario , Canada.

Previous studies from low-resource countries have highlighted concerns surrounding non-specific effects of whole-cell pertussis vaccination, particularly in females. We sought to examine the effects of sex and birth weight on health services utilization following first exposure to whole-cell pertussis vaccine. Using a self-controlled case series design and by calculating relative incidence ratios (RIRs), we compared the relative incidence of emergency department visits and/or hospital admissions between sexes and between birth weight quintiles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21645515.2019.1586029DOI Listing
March 2019
3 Reads

Parasitic infections during pregnancy need not affect infant antibody responses to early vaccination against Streptococcus pneumoniae, diphtheria, or Haemophilus influenzae type B.

PLoS Negl Trop Dis 2019 02 28;13(2):e0007172. Epub 2019 Feb 28.

Division of Infectious Diseases, Department of Pediatrics, Lucille Packard Children's Hospital at Stanford School of Medicine, Stanford, California, United States of America.

Background: Globally, vaccine-preventable diseases remain a significant cause of early childhood mortality despite concerted efforts to improve vaccine coverage. One reason for impaired protection may be the influence of prenatal exposure to parasitic antigens on the developing immune system. Prior research had shown a decrease in infant vaccine response after in utero parasite exposure among a maternal cohort without aggressive preventive treatment. Read More

View Article

Download full-text PDF

Source
http://dx.plos.org/10.1371/journal.pntd.0007172
Publisher Site
http://dx.doi.org/10.1371/journal.pntd.0007172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413956PMC
February 2019
10 Reads

Pathophysiology, causes and genetics of paediatric and adult bronchiectasis.

Respirology 2019 Feb 25. Epub 2019 Feb 25.

Department of Respiratory Biology, University of Cambridge, Cambridge, UK.

Bronchiectasis has historically been considered to be irreversible dilatation of the airways, but with modern imaging techniques it has been proposed that 'irreversible' be dropped from the definition. The upper limit of normal for the ratio of airway to arterial development increases with age, and a developmental perspective is essential. Bronchiectasis (and persistent bacterial bronchitis, PBB) is a descriptive term and not a diagnosis, and should be the start not the end of the patient's diagnostic journey. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/resp.13509DOI Listing
February 2019
4 Reads

The impact of vaccines on heterologous adaptive immunity.

Clin Microbiol Infect 2019 Feb 20. Epub 2019 Feb 20.

Infectious Diseases Research Group, Murdoch Children's Research Institute, Parkville, Australia; Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Australia.

Background: Vaccines induce antigen-specific memory in adaptive immune cells that enable long-lived protection against the target pathogen. In addition to this, several vaccines have beneficial effects greater than protection against their target pathogen. These non-specific effects are proposed to be the result of vaccine-induced immunomodulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmi.2019.02.016DOI Listing
February 2019
1 Read

The 112-Year Odyssey of Pertussis and Pertussis Vaccines-Mistakes Made and Implications for the Future.

Authors:
James D Cherry

J Pediatric Infect Dis Soc 2019 Feb 22. Epub 2019 Feb 22.

Department of Pediatrics, David Geffen School of Medicine at UCLA.

Effective diphtheria, tetanus toxoids, whole-cell pertussis (DTwP) vaccines became available in the 1930s, and they were put into routine use in the United States in the 1940s. Their use reduced the average rate of reported pertussis cases from 157 in 100 000 in the prevaccine era to <1 in 100 000 in the 1970s. Because of alleged reactions (encephalopathy and death), several countries discontinued (Sweden) or markedly decreased (United Kingdom, Germany, Japan) use of the vaccine. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/jpids/advance-article/doi/10.1093/j
Publisher Site
http://dx.doi.org/10.1093/jpids/piz005DOI Listing
February 2019
27 Reads

The immunomodulatory effects of measles-mumps-rubella vaccination on persistence of heterologous vaccine responses.

Immunol Cell Biol 2019 Feb 21. Epub 2019 Feb 21.

Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.

It is proposed that measles-containing vaccines have immunomodulatory effects which include a reduction in all-cause childhood mortality. The antibody response to heterologous vaccines provides a means to explore these immunomodulatory effects. This is the first study to investigate the influence of measles-mumps-rubella (MMR) vaccine on the persistence of antibodies to a broad range of heterologous infant vaccinations given in the first year of life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/imcb.12246DOI Listing
February 2019
5 Reads

Immunogenicity and safety of the diphtheria, pertussis, tetanus and inactivated poliovirus vaccine when co-administered with the human rotavirus vaccine (Rotarix) in healthy Japanese infants: a phase IV randomized study.

Hum Vaccin Immunother 2019 Feb 20:1-9. Epub 2019 Feb 20.

h Medicines Development Division , GSK , Tokyo , Japan.

Rotavirus infections have been reported to account for 40-50% of all hospitalized acute gastroenteritis cases in young children (<5 years) in Japan. Since 2011, Rotarix containing the live attenuated human rotavirus RIX4414 strain (HRV) has been licensed in Japan for infants. Vaccination against rotavirus is optional in Japan whereas administration of diphtheria, pertussis, tetanus, and inactivated poliovirus (DPT-IPV) vaccine is part of the national routine immunization program. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/21645515.2018.1
Publisher Site
http://dx.doi.org/10.1080/21645515.2018.1564441DOI Listing
February 2019
10 Reads

Neonatal pertussis diagnosis: low procalcitonin level and high lymphocyte count are able to discriminate pertussis from bacterial and viral infections.

New Microbiol 2019 Jan 20;42(1):49-51. Epub 2019 Feb 20.

Dipartimento di Pediatria Sistematica, Pediatria 1, AORN "Santobono-Pausilipon", Napoli, Italy.

Pertussis is quite frequent and severe among infants; therefore, rapid diagnosis and timely targeted therapy are essential. Although a molecular test for etiological diagnosis is now available, it may not be available everywhere, and therefore adjunctive diagnostic tests are still useful for presumptive diagnosis. We describe the use of procalcitonin (PCT) and lymphocyte count to discriminate among pertussis, bacterial and viral infections. Read More

View Article

Download full-text PDF

Source
January 2019
2 Reads

Pertactin-deficient isolates: evidence of increased circulation in Europe, 1998 to 2015.

Euro Surveill 2019 Feb;24(7)

Department of Medical Microbiology, Capital Medical University, Beijing, China.

IntroductionPertussis outbreaks have occurred in several industrialised countries using acellular pertussis vaccines (ACVs) since the 1990s. High prevalence of pertactin (PRN)-deficient isolates has been found in these countries.AimsTo evaluate in Europe: (i) whether proportions of PRN-deficient strains increased in consecutive collections of clinical isolates; (ii) if the frequency of PRN-deficient strains in countries correlated with the time since ACV introduction; (iii) the presence of pertussis toxin (PT)-, filamentous haemagglutinin (FHA)- or fimbriae (Fim)-deficient isolates. Read More

View Article

Download full-text PDF

Source
https://www.eurosurveillance.org/content/10.2807/1560-7917.E
Publisher Site
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.7.1700832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381657PMC
February 2019
17 Reads

Vaccination Practices Among Obstetrician/Gynecologists for Non-pregnant Patients.

Am J Prev Med 2019 Mar;56(3):429-436

Adult and Child Consortium for Health Outcomes Research and Delivery Science, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Introduction: Many non-pregnant women see obstetrician-gynecologists as their sole source of medical care, yet little is known about vaccination practices of obstetrician-gynecologists for non-pregnant patients. The objectives were to assess, among a national sample of obstetrician-gynecologists, practices related to vaccine delivery in non-pregnant patients and factors associated with stocking and administering more than three different vaccines to non-pregnant patients.

Methods: E-mail and mail surveys were administered July-October 2015, with analyses performed during October-November 2015 and April-June 2018. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07493797183238
Publisher Site
http://dx.doi.org/10.1016/j.amepre.2018.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383792PMC
March 2019
10 Reads

Enzyme-linked immunosorbent assay for detecting anti-pertussis toxin antibody in mouse.

Clin Exp Vaccine Res 2019 Jan 31;8(1):64-69. Epub 2019 Jan 31.

The Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Although the DTaP and Tdap vaccines used to prevent pertussis have been used for a long time, there is no standard method for measuring pertussis antigens. Therefore, this preliminary study was conducted to develop an enzyme-linked immunosorbent assay method using an animal model for measuring antibodies against pertussis toxin, the most important pertussis pathogenic antigen, in the sera of vaccinated mice.

Materials And Methods: Tohama phase I was cultured for 24-30 hours, and then pertussis toxin was purified from the culture medium by chromatography. Read More

View Article

Download full-text PDF

Source
https://synapse.koreamed.org/DOIx.php?id=10.7774/cevr.2019.8
Publisher Site
http://dx.doi.org/10.7774/cevr.2019.8.1.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369130PMC
January 2019
11 Reads

Development and implementation of standardized method for detecting immunogenicity of acellular pertussis vaccines in Korea.

Clin Exp Vaccine Res 2019 Jan 31;8(1):35-42. Epub 2019 Jan 31.

Vaccine Bio Research Institute, The Catholic University of Korea, Seoul, Korea.

Purpose: There is no standard method for confirming the immunogenicity of acellular pertussis vaccines. We tried to develop a local standard method for evaluating the immunogenicity of the three-component of acellular pertussis vaccines which was developed by a Korean local company.

Materials And Methods: The developed pertussis antigens (pertussis toxin, filamentous hemagglutinin, pertactin) were evaluated by in-house enzyme-linked immunosorbent assay (ELISA) using 189 negative sera, 25 positive sera, and 73 paired sera (pre- and post-Tdap [tetanus, diphtheria, and acellular pertussis] vaccinated sera). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7774/cevr.2019.8.1.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369126PMC
January 2019
7 Reads

Prenatal vaccination of mothers and hepatitis B vaccination of their infants.

Prev Med 2019 Apr 11;121:68-73. Epub 2019 Feb 11.

Center for Interdisciplinary Research in Women's Health, Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0587, USA. Electronic address:

Tetanus, diphtheria, and acellular pertussis (Tdap) vaccination and influenza vaccination are recommended during pregnancy primarily to prevent influenza and pertussis in mothers and their infants. This study examines associations between prenatal Tdap vaccination and influenza vaccination of mothers and hepatitis B vaccination of their infants. A retrospective cohort study was conducted using data from electronic medical records from 15,468 deliveries to 14,925 mothers occurring April 2, 2014-December 3, 2016 at a university hospital in Texas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ypmed.2019.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399050PMC
April 2019
1 Read

Boosting Teenagers With Acellular Pertussis Vaccines Containing Recombinant or Chemically Inactivated Pertussis Toxin: A Randomized Clinical Trial.

Clin Infect Dis 2018 Jul 26. Epub 2018 Jul 26.

Department of Paediatrics, Children's Hospital of Geneva, University Hospitals of Geneva.

Background: Protection induced by acellular pertussis (aP) vaccines is partial and short-lived, especially in teenagers, calling for novel immunization strategies.

Methods: We conducted an investigator-driven proof-of-concept randomized controlled trial in aP-primed adolescents in Geneva to assess the immunogenicity and reactogenicity of a novel recombinant aP (r-aP) vaccine including recombinant pertussis toxin (PT) and filamentous hemagglutinin (FHA) coadministered with tetanus-diphtheria toxoids (Td), compared to a licensed tetanus-diphtheria-aP vaccine containing chemically detoxified PT (cd/Tdap). The primary immunological endpoints were day 28/365 geometric mean concentrations (GMCs) of total and neutralizing anti-PT antibodies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciy594DOI Listing
July 2018
1 Read

Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy - a prospective, observational cohort study from the United Kingdom.

Clin Exp Immunol 2019 Feb 13. Epub 2019 Feb 13.

Section of Paediatrics, Department of Medicine, Imperial College London, UK.

The maternal Tdap (tetanus, diphtheria and acellular pertussis) vaccination programme in the United Kingdom has successfully reduced cases of pertussis in young infants. In addition to prevention of pertussis cases, it is also important to investigate the persistence of maternal antibodies during infancy and the possible interference of maternal antibodies with infant responses to vaccines. We recruited mother-infant pairs from vaccinated and unvaccinated pregnancies and measured concentrations of immunoglobulin (Ig)G against pertussis toxin (PTx), filamentous haemagglutinin (FHA), pertactin (Prn), diphtheria toxin (DTx), tetanus toxoid (TTx) Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae in mothers and infants at birth, and in infants at 7 weeks and at 5 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cei.13275DOI Listing
February 2019
2 Reads

The prevention of severe pertussis and pertussis deaths in young infants.

Authors:
James D Cherry

Expert Rev Vaccines 2019 Mar 22;18(3):205-208. Epub 2019 Feb 22.

a Department of Pediatrics , David Geffen School of Medicine at UCLA , Los Angeles , CA , USA.

Introduction: Today, in the developed world, virtually all deaths due to Bordetella pertussis illnesses occur in young infants. Areas Covered: Pertussis in young infants is characterized by an afebrile cough illness with coryza, apnea, seizures, cyanosis, and emesis. Severe illness is associated with high leukocyte and lymphocyte counts, rapid respiratory and cardiac rates and pneumonia. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14760584.2019.1
Publisher Site
http://dx.doi.org/10.1080/14760584.2019.1581065DOI Listing
March 2019
10 Reads

The use of multiplex PCR for the detection of atypical pathogens in Egyptian children with CAP: a high rate of in early infancy.

J Egypt Public Health Assoc 2019 18;94(1). Epub 2019 Jan 18.

2Department of Clinical Pathology, Faculty of Medicine, Cairo University, 2 Atteia Abd El Hadi St., El Maadi, Cairo, 11562 Egypt.

Background: Atypical pathogen infections played an important role in community-acquired pneumonia (CAP) in children. Pathogen-specific clinical symptoms are often lacking, and it is difficult to detect atypical pathogens by culture methods. The use of multiplex polymerase chain reaction (PCR) methods enables testing for many pathogens simultaneously in a single analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s42506-018-0003-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338716PMC
April 2019
9 Reads

A Phase III Study to Evaluate the Immunogenicity and Safety of GC1107 (Adult Tetanus Diphtheria Vaccine) in Healthy Adults.

J Korean Med Sci 2019 Jan 16;34(4):e31. Epub 2019 Jan 16.

Department of Pediatrics, Seoul St. Mary's Hosptial, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: This study was conducted to assess the immunogenicity and safety of GC1107 (adult tetanus diphtheria [Td] vaccine). The primary goal was to evaluate the non-inferiority of the immunogenicity of GC1107 compared to the control vaccine. Additionally, the safety profiles of GC1107 and the control vaccine were compared. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3346/jkms.2019.34.e31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345633PMC
January 2019
10 Reads

Policy support for expanding the adolescent vaccine school mandate in Pennsylvania to include the human papillomavirus (HPV) vaccine.

J Am Assoc Nurse Pract 2019 Apr;31(4):263-268

University of Pittsburgh School of Nursing, Pittsburgh, Pennsylvania.

Approximately 27,000 men and women are affected by human papillomavirus (HPV)-related cancer every year. The Advisory Committee for Immunization Practices and the Centers for Disease Control and Prevention (CDC) routinely recommend that adolescents receive HPV, tetanus, diphtheria, and acellular pertussis (tetanus-diphtheria-acellular pertussis [Tdap]) and meningococcal (MCV) vaccines at age 11-12 years. Although the CDC and professional organizations such as the American Academy of Pediatrics make national vaccine recommendations, according to the National Vaccine Information Center, it is the responsibility of "state health departments to make and enforce vaccine mandates for school entry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JXX.0000000000000142DOI Listing
April 2019
11 Reads

Post-marketing surveillance to assess the safety and tolerability of a combined diphtheria, tetanus, acellular pertussis and inactivated poliovirus vaccine (DTaP-IPV) in Korean children.

Hum Vaccin Immunother 2019 Jan 22:1-9. Epub 2019 Jan 22.

e Department of Pediatrics , Korea University College of Medicine , Seoul , Republic of Korea.

Infanrix-IPV (GSK, Belgium) is a diphtheria, tetanus, acellular pertussis, and inactivated poliovirus combination vaccine (DTaP-IPV) licensed in many countries including Korea. In accordance with Korean regulations, we conducted a post-marketing surveillance (PMS) to evaluate the safety of DTaP-IPV administered to Korean children in routine immunization schedules. Children aged <7 years receiving at least one dose of DTaP-IPV either as part of a primary (3-dose) vaccination series or as a subsequent booster were enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21645515.2019.1572406DOI Listing
January 2019
10 Reads

Factors Associated With Rotavirus Vaccine Coverage.

Pediatrics 2019 Feb 17;143(2). Epub 2019 Jan 17.

Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Rotavirus vaccines (RVVs) were included in the US immunization program in 2006 and are coadministered with the diphtheria-tetanus-acellular pertussis (DTaP) vaccine, yet their coverage lags behind DTaP. We assessed timing, initiation, and completion of the RVV series among children enrolled in active gastroenteritis surveillance at 7 US medical institutions during 2014-2016.

Methods: We compared coverage and timing of each vaccine series and analyzed characteristics associated with RVV initiation and completion. Read More

View Article

Download full-text PDF

Source
http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
Publisher Site
http://dx.doi.org/10.1542/peds.2018-1824DOI Listing
February 2019
16 Reads

Nasal swab bacteriology by PCR during the first 24-months of life: A prospective birth cohort study.

Pediatr Pulmonol 2019 Mar 4;54(3):289-296. Epub 2019 Jan 4.

Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia.

Background: Most respiratory bacterial carriage studies in children are based on cross-sectional samples or longitudinal studies with infrequent sampling points. The prospective Observational Research in Childhood Infectious Diseases birth cohort study intensively evaluated the community-based epidemiology of respiratory viruses and bacteria during the first 2-years of life. Here we report the bacteriologic findings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24231DOI Listing
March 2019
7 Reads

Assessing the timeliness of vaccine administration in children under five years in India, 2013.

Vaccine 2019 Jan 27;37(4):558-564. Epub 2018 Dec 27.

Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Infectious Disease, Michigan Medicine, 1500 E Medical Center Drive, Ann Arbor, MI, USA.

Morbidity from vaccine-preventable diseases is high in India, but precise estimates of vaccination timeliness are difficult to compute because many children lack records of vaccination dates. This study assessed vaccination timeliness after accounting for right and left censoring of data. This cross-sectional study used the 2012-2013 District Level Household and Facility Survey in India. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2018.12.035DOI Listing
January 2019
5 Reads

Comment on "The impact of past vaccination coverage and immunity on pertussis resurgence".

Sci Transl Med 2018 Dec;10(472)

Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Limitations in the data used for a recent modeling study of pertussis resurgence in the US may explain why the results were not consistent with several observational studies demonstrating a shorter duration of protection after acellular pertussis vaccine administration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aau0548DOI Listing
December 2018

Hemolytic uremic syndrome associated with Bordetella pertussis infection in a 2-month-old infant carrying a pathogenic variant in complement factor H.

Pediatr Nephrol 2019 Mar 17;34(3):533-537. Epub 2018 Dec 17.

Pediatric Nephrology Unit, Bordeaux University Hospital, Bordeaux, France.

Background: Hemolytic uremic syndrome (HUS) has been associated with a number of infectious agents. We report here the case of an infant with severe Bordetella pertussis infection who developed HUS.

Case Diagnosis/treatment: A 2-month-old preterm male was admitted for severe Bordetella pertussis infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00467-018-4174-1DOI Listing
March 2019
3 Reads

Treatment of hemolytic uremic syndrome related to Bordetella pertussis infection -is plasma exchange or eculizumab use necessary?

BMC Nephrol 2018 Dec 17;19(1):365. Epub 2018 Dec 17.

Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.

Background: Bordetella pertussis infection is a known trigger of atypical hemolytic uremic syndrome (HUS). For patients suspected of having atypical HUS, prompt plasma exchange/infusion (PE/PI) or eculizumab (ECZ) treatment is recommended.

Case Presentation: We report a 1-month-old female infant who was admitted with a severe cough and a B. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-018-1168-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297948PMC
December 2018
3 Reads

Serologic Status of Routine Childhood Vaccines, Cytomegalovirus, and Epstein-Barr Virus in Children With Inflammatory Bowel Disease.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

Section of Paediatric Gastroenterology, Department of Paediatrics, University of Calgary, Calgary, Alberta, Canada.

Background: Data on the serologic status of childhood vaccines, cytomegalovirus (CMV) and Epstein-Barr virus (EBV), are limited in inflammatory bowel disease (IBD). Therefore, we evaluated vaccine coverage and seroprotection, along with CMV and EBV seropositivity, in pediatric IBD.

Methods: In a cross-sectional study, demographic data, IBD history, vaccine records, and serum for antibodies against measles, mumps, rubella, diphtheria, tetanus, varicella, hepatitis B (HBV), CMV, and EBV were collected from children with IBD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ibd/izy366DOI Listing
December 2018
9 Reads

The uptake of adolescent vaccinations through the School Immunisation Program in specialist schools in Victoria, Australia.

Vaccine 2019 Jan 3;37(2):272-279. Epub 2018 Dec 3.

The Department of Paediatrics, The University of Melbourne, Melbourne, Australia; Department of General Medicine, The Royal Children's Hospital, Melbourne, Australia; Vaccine and Immunisation Research Group, Murdoch Children's Research Institute, Melbourne, Australia; The School of Population Health, The University of Melbourne, Melbourne, Australia.

Background: As part of the National Immunisation Program (NIP) students in Australia receive adolescent immunisations through the School Immunisation Program at 12 to 13 years. For children with disabilities attending specialist schools, no vaccine uptake data is collected at this time point. We aimed to determine uptake of diphtheria-tetanus-pertussis (dTpa) and Human Papillomavirus (HPV) immunisations amongst young people with disabilities in specialist schools in Victoria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2018.11.034DOI Listing
January 2019
4 Reads

Burden of Children Hospitalized With Pertussis in Canada in the Acellular Pertussis Vaccine Era, 1999-2015.

J Pediatric Infect Dis Soc 2018 Dec 8. Epub 2018 Dec 8.

Vaccine Evaluation Center, BC Children's Hospital, University of British Columbia, Vancouver, Canada.

Background: Recent increases in pertussis morbidity and mortality rates among young infants have led to a recommendation in some countries for vaccination against pertussis during pregnancy. Having data on the burden of pediatric pertussis in a large population over time is important for establishing the true burden of disease in the acellular pertussis (aP) vaccine era. Here, we describe age-specific epidemiology and morbidity and mortality rates in children hospitalized with pertussis over 17 years across Canada in the aP vaccine era. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jpids/piy128DOI Listing
December 2018
1 Read

Obstetrician-Gynecologists' Strategies to Address Vaccine Refusal Among Pregnant Women.

Obstet Gynecol 2019 Jan;133(1):40-47

Adult and Child Consortium for Health Outcomes Research and Delivery Science, the Department of Pediatrics, and the Department of Community and Behavioral Health, University of Colorado Anschutz Medical Campus, and Children's Hospital Colorado, Aurora, Colorado; the American College of Obstetricians and Gynecologists, Washington, DC; the National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; and the Division of General Internal Medicine, Denver Health, Denver, Colorado.

Objective: To describe 1) obstetrician-gynecologists' (ob-gyns') perceptions of the frequency of vaccine refusal among pregnant patients and perceived reasons for refusal and 2) ob-gyns' strategies used when encountering vaccine refusal and perceived effectiveness of those strategies.

Methods: We conducted an email and mail survey among a nationally representative network of ob-gyns from March 2016 to June 2016.

Results: The response rate was 69% (331/477). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/AOG.0000000000003005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411050PMC
January 2019
5 Reads

Seroprevalence of diphtheria and pertussis immunoglobulin G among children with pneumonia in Ji'nan, China.

BMC Pediatr 2018 Dec 5;18(1):383. Epub 2018 Dec 5.

Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Background: Vaccination is still one of the most important methods to control and prevent childhood infections including diphtheria and pertussis. This study evaluated the level of diphtheria (DT) and pertussis (PT)-related antibodies among children with pneumonia in Ji'nan, China.

Methods: A total of 484 sera of children from 1 day to 13 years of age were collected from 2014 to 2015 in Ji'nan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-018-1337-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282317PMC
December 2018
25 Reads

Use of different combination diphtheria-tetanus-acellular pertussis vaccines does not increase risk of 30-day infant mortality. A population-based linkage cohort study using administrative data from the Australian Childhood Immunisation Register and the National Death Index.

Vaccine 2019 Jan 28;37(2):280-288. Epub 2018 Nov 28.

Discipline of Paediatrics, School of Medicine, University of Adelaide, Adelaide, Australia; Robinson Research Institute, University of Adelaide, South Australia, Australia. Electronic address:

Objective: To determine whether differences in combination DTaP vaccine types at 2, 4 and 6 months of age were associated with mortality (all-cause or non-specific), within 30 days of vaccination.

Design: Observational nationwide cohort study.

Setting: Linked population data from the Australian Childhood Immunisation Register and National Death Index. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2018.11.025DOI Listing
January 2019
3 Reads

Attitudes of physicians concerning vaccines not included in the national immunization schedule.

Turk J Pediatr 2018 ;60(3):290-297

Departments of Social Pediatrics, Gazi University Faculty of Medicine, Ankara, Turkey.

Çataklı T, Duyan-Çamurdan A, Aksakal-Baran FN, Güven AE, Beyazova U. Attitudes of physicians concerning vaccines not included in the national immunization schedule. Turk J Pediatr 2018; 60: 290-297. Read More

View Article

Download full-text PDF

Source
http://www.turkishjournalpediatrics.org/doi.php?doi=10.24953
Publisher Site
http://dx.doi.org/10.24953/turkjped.2018.03.009DOI Listing
February 2019
19 Reads

Paediatric and adult bronchiectasis: Vaccination in prevention and management.

Respirology 2019 Feb 26;24(2):107-114. Epub 2018 Nov 26.

School of Medicine, Griffith University, Gold Coast, QLD, Australia.

Bronchiectasis has received increased attention recently, including an emphasis on preventing infective exacerbations that are associated with disease progression and lung function decline. While there are several bacteria and viruses associated with bronchiectasis, licensed vaccines are only currently available for Streptococcus pneumoniae, Haemophilus influenzae (H. influenzae protein D as a conjugate in a pneumococcal vaccine), Mycobacterium tuberculosis, Bordetella pertussis and influenza virus. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/resp.13446
Publisher Site
http://dx.doi.org/10.1111/resp.13446DOI Listing
February 2019
18 Reads

The Safety of Influenza and Pertussis Vaccination in Pregnancy in a Cohort of Australian Mother-Infant Pairs, 2012-2015: The FluMum Study.

Clin Infect Dis 2019 Jan;68(3):402-408

Menzies School of Health Research, Charles Darwin University, Tiwi, Northern Territory.

Background: Inactivated influenza vaccine (IIV) and pertussis vaccination are recommended in pregnancy. Limited safety data exist for women who received IIV vaccine during the first trimester of pregnancy or received both vaccines in pregnancy. We assessed adverse birth outcomes between vaccinated and unvaccinated pregnancies. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/cid/advance-article/doi/10.1093/cid
Publisher Site
http://dx.doi.org/10.1093/cid/ciy517DOI Listing
January 2019
25 Reads

The impact of timing of maternal influenza immunization on infant antibody levels at birth.

Clin Exp Immunol 2019 Feb 2;195(2):139-152. Epub 2018 Dec 2.

Mucosal Infection and Immunity Group, Section of Virology, Department of Medicine, St Mary's Campus, Imperial College London, UK.

Pregnant women and infants are at an increased risk of severe disease after influenza infection. Maternal immunization is a potent tool to protect both these at-risk groups. While the primary aim of maternal influenza vaccination is to protect the mother, a secondary benefit is the transfer of protective antibodies to the infant. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/cei.13234
Publisher Site
http://dx.doi.org/10.1111/cei.13234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330660PMC
February 2019
8 Reads

Effect of HIV exposure and timing of antiretroviral therapy initiation on immune memory responses to diphtheria, tetanus, whole cell pertussis and hepatitis B vaccines.

Expert Rev Vaccines 2019 01 19;18(1):95-104. Epub 2018 Nov 19.

a Department of Science and Technology, Health Sciences , National Research Foundation:Vaccine Preventable Diseases University of the Witwatersrand , Johannesburg , South Africa.

Objectives: We evaluated memory responses and antibody persistence to diphtheria-toxoid, tetanus-toxoid, whole-cell-pertussis (DTwP), and Hepatitis-B vaccines in HIV-unexposed, HIV-exposed-uninfected and HIV-infected children previously randomized to initiate time-limited ART at 6-10 weeks (ART-Immed) or when clinically/immunologically indicated (ART-Def).

Methods: All children received DTwP booster at 15-18 months. Antibodies were measured for pertussis-toxoid, filamentous haemagglutinin (FHA), diphtheria-toxoid, tetanus-toxoid, and hepatitis-B prior to booster, 1-2 weeks post-booster and at 24 months of age. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14760584.2019.1
Publisher Site
http://dx.doi.org/10.1080/14760584.2019.1547195DOI Listing
January 2019
35 Reads

Persistence of Antibodies against Diphtheria, Tetanus, Pertussis, and Poliovirus Types I, II, and III Following Immunization with DTaP Combined with Inactivated Wild-Type Polio Vaccine (DTaP-wIPV).

Jpn J Infect Dis 2019 Jan 31;72(1):49-52. Epub 2018 Oct 31.

Kawasaki City Institute for Public Health.

A follow-up serological study was conducted involving 47 subjects who received 4 doses of diphtheria and tetanus toxoids, combined with the acellular pertussis vaccine (DTaP) together with Salk-type inactivated polio vaccine (DTaP-wIPV), until 6 years of age. All antibody levels declined more rapidly than expected within 3 years after the completion of primary vaccination with the 4th booster dose, and titers persisted until 6 years of age. The positive rate of the IgG antibody against pertussis toxin (PT) was 31. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7883/yoken.JJID.2018.314DOI Listing
January 2019
3 Reads

secretor genotype and susceptibility to infections and chronic conditions in the ALSPAC cohort.

Wellcome Open Res 2018 25;3:65. Epub 2018 Sep 25.

Medical Research Council Integrative Epidemiology Unit, Avon Longitudinal Study of Parents and Children, Population Health Science, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.

The (fucosyltransferase-2) gene determines blood group secretor status. Being homozygous for the inactive "non-secretor" rs601338(A) allele confers resistance to certain infections (e.g. Read More

View Article

Download full-text PDF

Source
https://wellcomeopenresearch.org/articles/3-65/v1
Publisher Site
http://dx.doi.org/10.12688/wellcomeopenres.14636.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171556.2PMC
September 2018
18 Reads

Recommendations to control pertussis prioritized relative to economies: A Global Pertussis Initiative update.

Vaccine 2018 11 15;36(48):7270-7275. Epub 2018 Oct 15.

Department of Pediatrics, University of Pennsylvania and Vaxconsult, Doylestown, PA 19104, USA. Electronic address:

Pertussis is a vaccine-preventable disease that causes morbidity and mortality, particularly in infants and children <5 years of age. The Global Pertussis Initiative (GPI) recommendations represent a systematic evaluation and prioritization of strategies to prevent pertussis-related infant and child deaths, reduce global disease burden and prevent resurgence through vaccination strategies and public health policies at national, regional and local levels. The GPI recommendations are based on clinical trials and observational and surveillance data, which are essential in the planning, implementation and evaluation of vaccination practices and best use of available resources. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0264410X183139
Publisher Site
http://dx.doi.org/10.1016/j.vaccine.2018.10.028DOI Listing
November 2018
21 Reads