2,394 results match your criteria Pediatrics Pertussis

Association between the COVID-19 pandemic and pertussis derived from multiple nationwide data sources, France, 2013 to 2020.

Euro Surveill 2022 Jun;27(25)

Institut Pasteur, Université Paris Cité, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France.

BackgroundInterventions to mitigate the COVID-19 pandemic may impact other respiratory diseases.AimsWe aimed to study the course of pertussis in France over an 8-year period including the beginning of the COVID-19 pandemic and its association with COVID-19 mitigation strategies, using multiple nationwide data sources and regression models.MethodsWe analysed the number of French pertussis cases between 2013 and 2020, using PCR test results from nationwide outpatient laboratories (Source 1) and a network of the paediatric wards from 41 hospitals (Source 2). Read More

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Safety of tetanus, diphtheria, acellular pertussis (Tdap) vaccination during pregnancy.

Vaccine 2022 Jun 15. Epub 2022 Jun 15.

Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.

The objective of this study was to evaluate the safety of prenatal tetanus, diphtheria, acellular pertussis (Tdap) vaccination. This cohort study was conducted among pregnant members at Kaiser Permanente Southern California (KPSC). The exposed cohort consisted of women who received Tdap vaccine on or after the 27th week of pregnancy between January 2018 and January 2019. Read More

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Knowledge and decisions about maternal immunisation by pregnant women in Aotearoa New Zealand.

BMC Health Serv Res 2022 Jun 14;22(1):779. Epub 2022 Jun 14.

Division of Health Sciences , Kōhatu-Centre for Hauora Māori, Otago Medical School, University of Otago, PO Box 56 , 9054, Dunedin, New Zealand.

Background: Maternal vaccinations for influenza and pertussis are recommended in New Zealand to protect mothers and their infant from infection. However, maternal immunisation coverage in New Zealand is suboptimal. Furthermore, there is unacceptable inequitable maternal immunisation rates across the country with Māori and Pacific women having significantly lower maternal immunisation rates than those of other New Zealanders. Read More

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Do intentions lead to action? Results of a longitudinal study assessing determinants of Tdap vaccine uptake during pregnancy in Quebec, Canada.

BMC Pregnancy Childbirth 2022 Jun 13;22(1):477. Epub 2022 Jun 13.

CHU Sainte-Justine Research Center, Montreal, Qc, Canada.

Background: In Canada, vaccination against pertussis (Tdap) during pregnancy has been recommended since 2018, with suboptimal uptake. We aimed to assess the determinants of intention and uptake of Tdap vaccine among pregnant women in Quebec.

Methods: Participants (< 21 weeks of pregnancy) were recruited in four Quebec regions. Read More

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A retrospective study examining the clinical significance of testing respiratory panels in children who presented to a tertiary hospital in 2019.

Access Microbiol 2022 21;4(3):000332. Epub 2022 Mar 21.

Pediatrics Department, King Hamad University Hospital, Busaiteen, Bahrain.

Respiratory tract infections are a leading cause of hospital visits in the paediatric population and carry significant associated morbidity and mortality in this population. The introduction of respiratory panel testing has been said to guide clinicians in the overall management of patients. We conducted a retrospective study examining all respiratory panels carried out in our hospital during 2019 on paediatric patients. Read More

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Memory B Cell Activation Induced by Pertussis Booster Vaccination in Four Age Groups of Three Countries.

Front Immunol 2022 23;13:864674. Epub 2022 May 23.

National Institute for Public Health and the Environment, Centre for Infectious Disease Control, Bilthoven, Netherlands.

Background: Immunogenicity of acellular pertussis (aP) vaccines is conventionally assessed by measuring antibody responses but antibody concentrations wane quickly after vaccination. Memory B cells, however, are critical in sustaining long-term protection and therefore may be an important factor when assessing pertussis immunity after vaccination.

Aim: We studied pertussis specific memory B cell (re)activation induced by an aP booster vaccination in four different age groups within three countries. Read More

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Maternal Tdap Vaccination during Pregnancy: Impact on Infant Anti-pertussis Antibody Concentrations by Maternal Pertussis Priming Series.

Clin Infect Dis 2022 Jun 1. Epub 2022 Jun 1.

Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

Background: Acellular pertussis (aP) vaccines replaced whole cell pertussis (wP) vaccines for the U.S. childhood primary series in 1997. Read More

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Severe pertussis disease in a paediatric population: The role of age, vaccination status and prematurity.

Acta Paediatr 2022 May 31. Epub 2022 May 31.

Department of Pediatrics, Department of Health Sciences, University of Florence, Florence, Italy.

Aim: To estimate hospitalisation rate and investigate the role of age, prematurity and vaccination status in severe pertussis cases.

Methods: We retrospectively evaluated 200 children aged 0-14 years, admitted to the emergency rooms of Meyer Hospital of Florence and Pisa Hospital with a diagnosis of pertussis from 1 October 2010 to 31 January 2020.

Results: Children younger than 12 months were 63. Read More

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Long-Term Immunogenicity upon Pertussis Booster Vaccination in Young Adults and Children in Relation to Priming Vaccinations in Infancy.

Vaccines (Basel) 2022 Apr 28;10(5). Epub 2022 Apr 28.

National Institute for Public Health and the Environment, Centre for Infectious Disease Control, P.O. Box 1, 3720 BA Bilthoven, The Netherlands.

Booster vaccinations for pertussis are advised in many countries during childhood or adulthood. In a phase IV longitudinal interventional study, we assessed long-term immunity following an extra pertussis booster vaccination in children and adults. Children (9 years of age) were primed in infancy with either the Dutch whole cell pertussis (wP) vaccine ( = 49) or acellular pertussis (aP) vaccines ( = 59), and all children received a preschool aP booster. Read More

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Long-term clinical course and prognosis of vaccine-related persistent itching nodules (1997-2019): An observational study.

Vaccine X 2022 Aug 29;11:100163. Epub 2022 Apr 29.

Department of Paediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Vaccines adsorbed to aluminium can induce long-lasting intensely itching subcutaneous nodules (granulomas) at the injection site as well as contact allergy to aluminium. In clinical trials of a new acellular pertussis vaccine performed in the 1990s (Gothenburg, Sweden) with 76 000 participants, itching nodules were reported in 745 children. A positive patch test to aluminium was verified in 77% of the tested children with itchy nodules. Read More

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Decay of anti-Bordetella pertussis antibodies in women of childbearing age following COVID-19 non-pharmaceutical measures.

Vaccine 2022 Jun 11;40(27):3746-3751. Epub 2022 May 11.

BC Children's Hospital Research Institute, Vancouver, Canada; Department of Pediatrics, University of British Columbia, Vancouver, Canada. Electronic address:

Background: Immunization against Bordetella pertussis during pregnancy reduces morbidity from severe pertussis in young infants via trans-placental transfer of anti-B. pertussis Immunoglobulin G (IgG). Studies have reported a near disappearance of respiratory pathogens including B. Read More

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Development of effective messages to promote maternal immunization in Kenya.

Vaccine 2022 Jun 20;40(27):3761-3770. Epub 2022 May 20.

Emory University, Rollins School of Public Health, Hubert Department of Global Health, 1518 Clifton Rd, Atlanta, GA 30322, United States; Emory University, Rollins School of Public Health, Department of Epidemiology, 1518 Clifton Rd, Atlanta, GA 30322, United States; Emory University, Rollins School of Public Health, Department of Pediatrics, 1518 Clifton Rd, Atlanta, GA 30322, United States; Yale Global Health Institute, New Haven, CT, United States.

Objectives: This study evaluated messages and communication approaches for maternal immunization uptake in Kenya. We identified persuasive communication aspects that would inform maternal immunization attitudes, intent, and vaccine uptake.

Methods: We conducted a two-phased mixed methods study with pregnant women and their male partners in three regions of Kenya. Read More

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Clinical evaluation of a new rapid immunochromatographic test for detection of Bordetella pertussis antigen.

Sci Rep 2022 May 16;12(1):8069. Epub 2022 May 16.

Department of Medical Welfare for Children, Kawasaki University of Medical Welfare, Okayama, Japan.

A more rapid and less complicated test to diagnose pertussis is required in clinical settings. We need to detect Bordetella pertussis, which mainly causes pertussis, as early as possible, because pertussis is more likely to become severe in infants, and people around them can easily become a source of infection due to its strong infectivity. Nevertheless, methods that can detect B. Read More

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Flu and pertussis vaccination during pregnancy in Geneva during the COVID-19 pandemic: A multicentric, prospective, survey-based study.

Vaccine 2022 May 6;40(25):3455-3460. Epub 2022 May 6.

Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva (HUG), Geneva, Switzerland; Faculty of Medicine, University of Geneva, Switzerland. Electronic address:

Objective: To determine pertussis and influenza vaccination coverage during pregnancy among women delivering in all the maternities of Geneva (Switzerland), during the COVID-19 pandemic.

Methods: All women delivering in all the maternity centres of the canton of Geneva from 1st November 2020 to 30th November 2020 (beginning of the flu vaccination season) and from 8th March 2021 to 7th April 2021 (end of the flu vaccination season) had their records checked upon admission to the labour ward regarding pertussis and influenza vaccination during pregnancy. Reasons for non-vaccination were recorded. Read More

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Infants' diminished response to DTaP vaccine is associated with exposure to organophosphate esters.

Sci Total Environ 2022 Sep 6;837:155782. Epub 2022 May 6.

Nicholas School of Environment, Duke University, 9 Circuit Drive, Box 90328, Durham, NC 27708, USA; Children's Health & Discovery Initiative, Duke School of Medicine, Chesterfield Building, 701 W. Main St., Durham, NC 27710, USA. Electronic address:

Organophosphate esters (OPEs) are commonly applied as flame retardants and plasticizers. Toxicological studies suggest exposure effects on immune endpoints, raising concerns as infants' OPE exposures are elevated compared to older children and adults due to hand-to-mouth behavior and breastfeeding. Here, we sought to evaluate the immune responsiveness of infants to a neoantigen (e. Read More

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September 2022

Parental and provider vaccine hesitancy and non-timely childhood vaccination in Switzerland.

Vaccine 2022 May 26;40(23):3193-3202. Epub 2022 Apr 26.

University of Basel, Basel, Switzerland; University Department of Medicine, Kantonsspital Baselland, Bruderholz, Switzerland. Electronic address:

Objective: Although medical providers are a trusted vaccination information source for parents, they do not universally support vaccination. Complementary medicine (CM) providers are particularly likely to hold vaccine hesitant (VH) views, and VH parents often consult with them. Little research compares VH of parents and providers, and if and how each is associated with uptake of recommended childhood vaccines. Read More

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Global spatial dynamics and vaccine-induced fitness changes of .

Sci Transl Med 2022 04 27;14(642):eabn3253. Epub 2022 Apr 27.

Insitut Pasteur, Université Paris Cité, Mathematical Modelling of Infectious Diseases Unit, UMR2000, CNRS, 75015 Paris, France.

As with other pathogens, competitive interactions between strains drive infection risk. Vaccines are thought to perturb strain diversity through shifts in immune pressures; however, this has rarely been measured because of inadequate data and analytical tools. We used 3344 sequences from 23 countries to show that, on average, there are 28. Read More

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Antibiotic Use and Vaccine Antibody Levels.

Pediatrics 2022 05;149(5)

Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, New York.

Background: The majority of children are prescribed antibiotics in the first 2 years of life while vaccine-induced immunity develops. Researchers have suggested a negative association of antibiotic use with vaccine-induced immunity in adults, but data are lacking in children.

Methods: From 2006 to 2016, children aged 6 to 24 months were observed in a cohort study. Read More

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Epidemiology, prevention and control of pertussis in Spain: New vaccination strategies for lifelong protection.

Enferm Infecc Microbiol Clin (Engl Ed) 2022 04;40(4):195-203

Pediatrics, Hospital Materno Infantil, Badajoz, Spain.

Pertussis is a highly contagious, vaccine-preventable respiratory tract infection, with high morbidity and mortality and a particularly severe effect on newborns and infants under 2 months. The first pertussis vaccines were introduced in the 1940s. Since 1980, however, the incidence of cases has risen despite the extensive vaccination programmes and antibiotic adjuvant treatments available. Read More

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An Informed Approach to Vaccine Hesitancy and Uptake in Children.

Dela J Public Health 2022 Mar 29;8(1):60-64. Epub 2022 Mar 29.

Attending Physician, Divisions of Orthogenetics & Palliative Medicine, Nemours Children's Health; Clinical Associate Professor, Pediatrics, Sidney Kimmel Medical College, Thomas Jefferson University.

The tremendous success of vaccination programs worldwide over the past two centuries has produced a paradoxical effect whereby a lack of exposure to the devastating consequences of vaccine-preventable diseases has created an environment in which fear of the side effects of vaccines can overshadow concerns about the impact of the diseases they are meant to prevent. As vaccine hesitancy grew over the past twenty years, states passed legislation, such as non-medical exemptions from vaccination, that have cultivated pockets of poor vaccine uptake allowing for the return of vaccine-preventable diseases such as measles and pertussis. The COVID-19 pandemic has further intensified mistrust of vaccines, impacting both the reasons for vaccine hesitancy and the attributes of vaccine hesitant parents. Read More

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Physician vaccination practices in mild to moderate inborn errors of immunity and retrospective review of vaccine completeness in IEI: results from the Canadian Immunization Research Network.

Allergy Asthma Clin Immunol 2022 Apr 9;18(1):32. Epub 2022 Apr 9.

Departments of Pediatrics and Community Health and Epidemiology, Canadian Center for Vaccinology, IWK Health Centre, Dalhousie University, Halifax, Canada.

Background And Objectives: Safety and effectiveness concerns may preclude physicians from recommending vaccination in mild/moderate inborn errors of immunity (IEI). This study describes attitudes and practices regarding vaccination among physicians who care for patients with mild/moderate B cell or mild/moderate combined immunodeficiencies (CID) and vaccination completeness among patients diagnosed with IEIs.

Methods: Canadian physicians caring for children with IEI were surveyed about attitudes and practices regarding vaccination in mild/moderate IEI. Read More

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Vaccination coverage rates and attitudes towards mandatory vaccinations among healthcare personnel in tertiary-care hospitals in Greece.

Expert Rev Vaccines 2022 Jun 13;21(6):853-859. Epub 2022 Apr 13.

Pathophysiology Department, Medical School, National and Kapodistrian University of Athens, and General Hospital of Athens Laiko, Athens, Greece.

Objectives: Our aim was to estimate vaccination and susceptibility rates against vaccine-preventable diseases among healthcare personnel (HCP) in eight hospitals.

Methods: Cross-sectional survey.

Results: A total of 1284 HCP participated (physicians: 31. Read More

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Episodic apnea: gastroesophageal reflux associated with gastric organo-axial malrotation: a case report.

J Med Case Rep 2022 Apr 5;16(1):133. Epub 2022 Apr 5.

Department of Pediatrics, Faculty of Medicine, Ege University Children's Hospital, Bornova, Izmir, 35100, Turkey.

Background: Gastroesophageal reflux is a normal physiologic process occurring several times a day in healthy infants. On the other hand, symptoms such as failure to thrive, feeding or sleeping problems, chronic respiratory distress, persistent forceful vomiting, and choking may indicate reflux associated with underlying anatomic, neurological, or infectious abnormalities. Gastric malrotation is an extremely rare disorder in the pediatric population and one of the anatomic causes associated with severe reflux, which could lead to serious complications. Read More

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Predicting HPV vaccination among Tdap vaccinated adolescents in Georgia at the county level.

Ann Epidemiol 2022 Jun 28;70:74-78. Epub 2022 Mar 28.

Department of Public Health Sciences, Clemson University, SC.

Purpose: Vaccinations are reported at the state level, but services are delivered at the county level through health departments (HD). This research contributes statistical models to predict county level HPV vaccination.

Methods: Using a cross sectional study design, secondary data were analyzed for the years 2016-2018 for all counties of GA. Read More

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Pertussis toxin neutralizing antibody response after an acellular booster vaccination in Dutch and Finnish participants of different age groups.

Emerg Microbes Infect 2022 Dec;11(1):956-963

Institute of Biomedicine, University of Turku, Turku, Finland.

Pertussis incidence has increased in many countries and the disease occurs among all age groups, suggesting the need for booster immunizations through life. In addition to determining the concentration of anti-pertussis toxin (PT) antibodies, the ability of PT neutralizing antibodies (PTNAs) could be used to assess vaccine responses.Altogether 258 participants [7-10-year-old (N = 73), 11-15-year-old (N = 85), 20-35-year-old (N = 50) and 60-70-year-old (N = 50)] were included. Read More

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December 2022

Evidence of suboptimal maternal vaccination coverage in pregnant New Zealand women and increasing inequity over time: A nationwide retrospective cohort study.

Vaccine 2022 03 2;40(14):2150-2160. Epub 2022 Mar 2.

Kōhatu - Centre for Hauora Māori, Division of Health Sciences, University of Otago, New Zealand.

Background: Adequate maternal vaccination coverage is critical for the prevention and control of infectious disease outbreaks such as pertussis, influenza, and more recently COVID-19. To guide efforts to increase vaccination coverage this study examined the extent of vaccination coverage in pregnant New Zealand women over time by area-level deprivation and ethnicity.

Methods: A retrospective cohort study was used consisting of all pregnant women who delivered between 01 January 2013 and 31 December 2018, using administrative health datasets. Read More

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Safety of primary immunization with a DTwP-HBV/Hib vaccine in healthy infants: a prospective, open-label, interventional, phase IV clinical study.

Expert Rev Vaccines 2022 05 7;21(5):685-692. Epub 2022 Mar 7.

Department of Pediatrics, Philippine General Hospital, University of the Philippines Manila, Philippines.

Objective: This study aimed to assess the safety of a fully liquid DTwP-HBV/Hib pentavalent vaccine (Eupenta) based on the occurrence of adverse events (AEs) following vaccination.

Methods: This was a prospective, open-label, single-arm, interventional phase IV study. A single intramuscular injection of the study vaccine was administered to infants at approximately 6, 10, and 14 weeks of age, and an end-of-study follow-up visit was scheduled at 18 weeks. Read More

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Increasing Uptake of Maternal Pertussis Vaccinations through Funded Administration in Community Pharmacies.

Vaccines (Basel) 2022 Jan 20;10(2). Epub 2022 Jan 20.

Department of Paediatrics, Child and Youth Health, University of Auckland, Auckland 1023, New Zealand.

Although maternal pertussis vaccination is recommended, uptake is suboptimal in New Zealand (NZ), despite full funding in general practice and hospitals. We determined whether funding maternal pertussis vaccination in community pharmacy increases its uptake. Pertussis vaccination during pregnancy was compared between non-contiguous, demographically similar regions of NZ. Read More

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January 2022

Loop-Mediated Isothermal Amplification Coupled With Nanoparticle-Based Lateral Biosensor for Rapid, Sensitive, and Specific Detection of .

Front Bioeng Biotechnol 2021 8;9:797957. Epub 2022 Feb 8.

Experiment Center, Captital Institute of Pediatrics, Beijing, China.

is the most frequent causative agent for pertussis, which is a highly contagious disease. Here, we developed a method based on loop-mediated isothermal amplification (LAMP) and nanoparticle-based lateral flow biosensor (LFB) for the timely diagnosis of infections. A set of six primers was designed for LAMP reactions, and the LAMP results were rapidly and visually indicated using LFB. Read More

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February 2022

Immunization data quality and decision making in pertussis outbreak management in southern Ethiopia: a cross sectional study.

Arch Public Health 2022 Feb 14;80(1):49. Epub 2022 Feb 14.

Department of Paediatrics & Child Health, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

Background: The aim of this study was to investigate the quality of immunization data and monitoring systems in the Dara Malo District (Woreda) of the Gamo Administrative Zone, within the Southern Nations, Nationalities, and Peoples' Region (SNNPR) of Ethiopia.

Methods: A cross-sectional study was conducted from August 4 to September 27, 2019, in Dara Malo District. The district was purposively selected during the management of a pertussis outbreak, based on a hypothesis of 'there is no difference in reported and recounted immunization status of children 7 to 23 months in Dara Malo District of Ethiopia'. Read More

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February 2022