1,968 results match your criteria Pediatrics Pertussis


Vaccination Practices Among Obstetrician/Gynecologists for Non-pregnant Patients.

Am J Prev Med 2019 Mar;56(3):429-436

Adult and Child Consortium for Health Outcomes Research and Delivery Science, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Introduction: Many non-pregnant women see obstetrician-gynecologists as their sole source of medical care, yet little is known about vaccination practices of obstetrician-gynecologists for non-pregnant patients. The objectives were to assess, among a national sample of obstetrician-gynecologists, practices related to vaccine delivery in non-pregnant patients and factors associated with stocking and administering more than three different vaccines to non-pregnant patients.

Methods: E-mail and mail surveys were administered July-October 2015, with analyses performed during October-November 2015 and April-June 2018. Read More

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http://dx.doi.org/10.1016/j.amepre.2018.10.025DOI Listing

Enzyme-linked immunosorbent assay for detecting anti-pertussis toxin antibody in mouse.

Clin Exp Vaccine Res 2019 Jan 31;8(1):64-69. Epub 2019 Jan 31.

The Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Although the DTaP and Tdap vaccines used to prevent pertussis have been used for a long time, there is no standard method for measuring pertussis antigens. Therefore, this preliminary study was conducted to develop an enzyme-linked immunosorbent assay method using an animal model for measuring antibodies against pertussis toxin, the most important pertussis pathogenic antigen, in the sera of vaccinated mice.

Materials And Methods: Tohama phase I was cultured for 24-30 hours, and then pertussis toxin was purified from the culture medium by chromatography. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.7774/cevr.2019.8
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http://dx.doi.org/10.7774/cevr.2019.8.1.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369130PMC
January 2019
1 Read

Development and implementation of standardized method for detecting immunogenicity of acellular pertussis vaccines in Korea.

Clin Exp Vaccine Res 2019 Jan 31;8(1):35-42. Epub 2019 Jan 31.

Vaccine Bio Research Institute, The Catholic University of Korea, Seoul, Korea.

Purpose: There is no standard method for confirming the immunogenicity of acellular pertussis vaccines. We tried to develop a local standard method for evaluating the immunogenicity of the three-component of acellular pertussis vaccines which was developed by a Korean local company.

Materials And Methods: The developed pertussis antigens (pertussis toxin, filamentous hemagglutinin, pertactin) were evaluated by in-house enzyme-linked immunosorbent assay (ELISA) using 189 negative sera, 25 positive sera, and 73 paired sera (pre- and post-Tdap [tetanus, diphtheria, and acellular pertussis] vaccinated sera). Read More

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http://dx.doi.org/10.7774/cevr.2019.8.1.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369126PMC
January 2019
2 Reads

Prenatal vaccination of mothers and hepatitis B vaccination of their infants.

Prev Med 2019 Feb 11;121:68-73. Epub 2019 Feb 11.

Center for Interdisciplinary Research in Women's Health, Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0587, USA. Electronic address:

Tetanus, diphtheria, and acellular pertussis (Tdap) vaccination and influenza vaccination are recommended during pregnancy primarily to prevent influenza and pertussis in mothers and their infants. This study examines associations between prenatal Tdap vaccination and influenza vaccination of mothers and hepatitis B vaccination of their infants. A retrospective cohort study was conducted using data from electronic medical records from 15,468 deliveries to 14,925 mothers occurring April 2, 2014-December 3, 2016 at a university hospital in Texas. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.02.013DOI Listing
February 2019

Boosting Teenagers With Acellular Pertussis Vaccines Containing Recombinant or Chemically Inactivated Pertussis Toxin: A Randomized Clinical Trial.

Clin Infect Dis 2018 Jul 26. Epub 2018 Jul 26.

Department of Paediatrics, Children's Hospital of Geneva, University Hospitals of Geneva.

Background: Protection induced by acellular pertussis (aP) vaccines is partial and short-lived, especially in teenagers, calling for novel immunization strategies.

Methods: We conducted an investigator-driven proof-of-concept randomized controlled trial in aP-primed adolescents in Geneva to assess the immunogenicity and reactogenicity of a novel recombinant aP (r-aP) vaccine including recombinant pertussis toxin (PT) and filamentous hemagglutinin (FHA) coadministered with tetanus-diphtheria toxoids (Td), compared to a licensed tetanus-diphtheria-aP vaccine containing chemically detoxified PT (cd/Tdap). The primary immunological endpoints were day 28/365 geometric mean concentrations (GMCs) of total and neutralizing anti-PT antibodies. Read More

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http://dx.doi.org/10.1093/cid/ciy594DOI Listing
July 2018
1 Read

Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy- a prospective, observational cohort study from the UK.

Clin Exp Immunol 2019 Feb 13. Epub 2019 Feb 13.

Section of Paediatrics, Department of Medicine, Imperial College London, UK.

The maternal Tdap (tetanus, diphtheria and acellular pertussis) vaccination program in the UK has successfully reduced cases of pertussis in young infants. In addition to prevention of pertussis cases, it is also important to investigate persistence of maternal antibody during infancy and possible interference of maternal antibodies with infant responses to vaccines. We recruited mother-infant pairs from vaccinated and unvaccinated pregnancies and measured concentrations of IgG against pertussis toxin (PTx), filamentous hemagglutinin (FHA), pertactin (Prn), diphtheria toxin (DTx), tetanus toxoid (TTx) Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae in mothers and infants at birth, and in infants at 7 weeks and at 5 months. Read More

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http://dx.doi.org/10.1111/cei.13275DOI Listing
February 2019

The prevention of severe pertussis and pertussis deaths in young infants.

Authors:
James D Cherry

Expert Rev Vaccines 2019 Feb 8. Epub 2019 Feb 8.

a Department of Pediatrics , David Geffen School of Medicine at UCLA , Los Angeles , CA , USA.

Introduction: Today, in the developed world, virtually all deaths due to Bordetella pertussis illnesses occur in young infants. Therefore, it is important to discuss severe pertussis and its prevention. Areas Covered: These infant deaths are frequently misdiagnosed. Read More

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https://www.tandfonline.com/doi/full/10.1080/14760584.2019.1
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http://dx.doi.org/10.1080/14760584.2019.1581065DOI Listing
February 2019
4 Reads

The use of multiplex PCR for the detection of atypical pathogens in Egyptian children with CAP: a high rate of in early infancy.

J Egypt Public Health Assoc 2019 18;94(1). Epub 2019 Jan 18.

2Department of Clinical Pathology, Faculty of Medicine, Cairo University, 2 Atteia Abd El Hadi St., El Maadi, Cairo, 11562 Egypt.

Background: Atypical pathogen infections played an important role in community-acquired pneumonia (CAP) in children. Pathogen-specific clinical symptoms are often lacking, and it is difficult to detect atypical pathogens by culture methods. The use of multiplex polymerase chain reaction (PCR) methods enables testing for many pathogens simultaneously in a single analysis. Read More

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http://dx.doi.org/10.1186/s42506-018-0003-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338716PMC
January 2019
7 Reads

A Phase III Study to Evaluate the Immunogenicity and Safety of GC1107 (Adult Tetanus Diphtheria Vaccine) in Healthy Adults.

J Korean Med Sci 2019 Jan 16;34(4):e31. Epub 2019 Jan 16.

Department of Pediatrics, Seoul St. Mary's Hosptial, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: This study was conducted to assess the immunogenicity and safety of GC1107 (adult tetanus diphtheria [Td] vaccine). The primary goal was to evaluate the non-inferiority of the immunogenicity of GC1107 compared to the control vaccine. Additionally, the safety profiles of GC1107 and the control vaccine were compared. Read More

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http://dx.doi.org/10.3346/jkms.2019.34.e31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345633PMC
January 2019
2 Reads

Policy support for expanding the adolescent vaccine school mandate in Pennsylvania to include the human papillomavirus (HPV) vaccine.

J Am Assoc Nurse Pract 2019 Jan 11. Epub 2019 Jan 11.

University of Pittsburgh School of Nursing, Pittsburgh, Pennsylvania.

Approximately 27,000 men and women are affected by human papillomavirus (HPV)-related cancer every year. The Advisory Committee for Immunization Practices and the Centers for Disease Control and Prevention (CDC) routinely recommend that adolescents receive HPV, tetanus, diphtheria, and acellular pertussis (tetanus-diphtheria-acellular pertussis [Tdap]) and meningococcal (MCV) vaccines at age 11-12 years. Although the CDC and professional organizations such as the American Academy of Pediatrics make national vaccine recommendations, according to the National Vaccine Information Center, it is the responsibility of "state health departments to make and enforce vaccine mandates for school entry. Read More

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http://dx.doi.org/10.1097/JXX.0000000000000142DOI Listing
January 2019
5 Reads

Post-marketing surveillance to assess the safety and tolerability of a combined diphtheria, tetanus, acellular pertussis and inactivated poliovirus vaccine (DTaP-IPV) in Korean children.

Hum Vaccin Immunother 2019 Jan 22. Epub 2019 Jan 22.

e Department of Pediatrics , Korea University College of Medicine , Seoul , Republic of Korea.

Infanrix-IPV (GSK, Belgium) is a diphtheria, tetanus, acellular pertussis, and inactivated poliovirus combination vaccine (DTaP-IPV) licensed in many countries including Korea. In accordance with Korean regulations, we conducted a post-marketing surveillance (PMS) to evaluate the safety of DTaP-IPV administered to Korean children in routine immunization schedules. Children aged <7 years receiving at least one dose of DTaP-IPV either as part of a primary (3-dose) vaccination series or as a subsequent booster were enrolled. Read More

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http://dx.doi.org/10.1080/21645515.2019.1572406DOI Listing
January 2019
6 Reads

Factors Associated With Rotavirus Vaccine Coverage.

Pediatrics 2019 Jan 17. Epub 2019 Jan 17.

Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Rotavirus vaccines (RVVs) were included in the US immunization program in 2006 and are coadministered with the diphtheria-tetanus-acellular pertussis (DTaP) vaccine, yet their coverage lags behind DTaP. We assessed timing, initiation, and completion of the RVV series among children enrolled in active gastroenteritis surveillance at 7 US medical institutions during 2014-2016.

Methods: We compared coverage and timing of each vaccine series and analyzed characteristics associated with RVV initiation and completion. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-1824DOI Listing
January 2019
8 Reads

Nasal swab bacteriology by PCR during the first 24-months of life: A prospective birth cohort study.

Pediatr Pulmonol 2019 Mar 4;54(3):289-296. Epub 2019 Jan 4.

Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia.

Background: Most respiratory bacterial carriage studies in children are based on cross-sectional samples or longitudinal studies with infrequent sampling points. The prospective Observational Research in Childhood Infectious Diseases birth cohort study intensively evaluated the community-based epidemiology of respiratory viruses and bacteria during the first 2-years of life. Here we report the bacteriologic findings. Read More

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http://dx.doi.org/10.1002/ppul.24231DOI Listing
March 2019
1 Read

Assessing the timeliness of vaccine administration in children under five years in India, 2013.

Vaccine 2019 Jan 27;37(4):558-564. Epub 2018 Dec 27.

Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Infectious Disease, Michigan Medicine, 1500 E Medical Center Drive, Ann Arbor, MI, USA.

Morbidity from vaccine-preventable diseases is high in India, but precise estimates of vaccination timeliness are difficult to compute because many children lack records of vaccination dates. This study assessed vaccination timeliness after accounting for right and left censoring of data. This cross-sectional study used the 2012-2013 District Level Household and Facility Survey in India. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.12.035DOI Listing
January 2019
2 Reads

Comment on "The impact of past vaccination coverage and immunity on pertussis resurgence".

Sci Transl Med 2018 Dec;10(472)

Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Limitations in the data used for a recent modeling study of pertussis resurgence in the US may explain why the results were not consistent with several observational studies demonstrating a shorter duration of protection after acellular pertussis vaccine administration. Read More

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http://dx.doi.org/10.1126/scitranslmed.aau0548DOI Listing
December 2018

Hemolytic uremic syndrome associated with Bordetella pertussis infection in a 2-month-old infant carrying a pathogenic variant in complement factor H.

Pediatr Nephrol 2019 Mar 17;34(3):533-537. Epub 2018 Dec 17.

Pediatric Nephrology Unit, Bordeaux University Hospital, Bordeaux, France.

Background: Hemolytic uremic syndrome (HUS) has been associated with a number of infectious agents. We report here the case of an infant with severe Bordetella pertussis infection who developed HUS.

Case Diagnosis/treatment: A 2-month-old preterm male was admitted for severe Bordetella pertussis infection. Read More

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http://dx.doi.org/10.1007/s00467-018-4174-1DOI Listing
March 2019
2 Reads

Treatment of hemolytic uremic syndrome related to Bordetella pertussis infection -is plasma exchange or eculizumab use necessary?

BMC Nephrol 2018 Dec 17;19(1):365. Epub 2018 Dec 17.

Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.

Background: Bordetella pertussis infection is a known trigger of atypical hemolytic uremic syndrome (HUS). For patients suspected of having atypical HUS, prompt plasma exchange/infusion (PE/PI) or eculizumab (ECZ) treatment is recommended.

Case Presentation: We report a 1-month-old female infant who was admitted with a severe cough and a B. Read More

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http://dx.doi.org/10.1186/s12882-018-1168-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297948PMC
December 2018
2 Reads

Serologic Status of Routine Childhood Vaccines, Cytomegalovirus, and Epstein-Barr Virus in Children With Inflammatory Bowel Disease.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

Section of Paediatric Gastroenterology, Department of Paediatrics, University of Calgary, Calgary, Alberta, Canada.

Background: Data on the serologic status of childhood vaccines, cytomegalovirus (CMV) and Epstein-Barr virus (EBV), are limited in inflammatory bowel disease (IBD). Therefore, we evaluated vaccine coverage and seroprotection, along with CMV and EBV seropositivity, in pediatric IBD.

Methods: In a cross-sectional study, demographic data, IBD history, vaccine records, and serum for antibodies against measles, mumps, rubella, diphtheria, tetanus, varicella, hepatitis B (HBV), CMV, and EBV were collected from children with IBD. Read More

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http://dx.doi.org/10.1093/ibd/izy366DOI Listing
December 2018
3 Reads

The uptake of adolescent vaccinations through the School Immunisation Program in specialist schools in Victoria, Australia.

Vaccine 2019 Jan 3;37(2):272-279. Epub 2018 Dec 3.

The Department of Paediatrics, The University of Melbourne, Melbourne, Australia; Department of General Medicine, The Royal Children's Hospital, Melbourne, Australia; Vaccine and Immunisation Research Group, Murdoch Children's Research Institute, Melbourne, Australia; The School of Population Health, The University of Melbourne, Melbourne, Australia.

Background: As part of the National Immunisation Program (NIP) students in Australia receive adolescent immunisations through the School Immunisation Program at 12 to 13 years. For children with disabilities attending specialist schools, no vaccine uptake data is collected at this time point. We aimed to determine uptake of diphtheria-tetanus-pertussis (dTpa) and Human Papillomavirus (HPV) immunisations amongst young people with disabilities in specialist schools in Victoria. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.11.034DOI Listing
January 2019
2 Reads

Burden of Children Hospitalized With Pertussis in Canada in the Acellular Pertussis Vaccine Era, 1999-2015.

J Pediatric Infect Dis Soc 2018 Dec 8. Epub 2018 Dec 8.

Vaccine Evaluation Center, BC Children's Hospital, University of British Columbia, Vancouver, Canada.

Background: Recent increases in pertussis morbidity and mortality rates among young infants have led to a recommendation in some countries for vaccination against pertussis during pregnancy. Having data on the burden of pediatric pertussis in a large population over time is important for establishing the true burden of disease in the acellular pertussis (aP) vaccine era. Here, we describe age-specific epidemiology and morbidity and mortality rates in children hospitalized with pertussis over 17 years across Canada in the aP vaccine era. Read More

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http://dx.doi.org/10.1093/jpids/piy128DOI Listing
December 2018

Obstetrician-Gynecologists' Strategies to Address Vaccine Refusal Among Pregnant Women.

Obstet Gynecol 2019 Jan;133(1):40-47

Adult and Child Consortium for Health Outcomes Research and Delivery Science, the Department of Pediatrics, and the Department of Community and Behavioral Health, University of Colorado Anschutz Medical Campus, and Children's Hospital Colorado, Aurora, Colorado; the American College of Obstetricians and Gynecologists, Washington, DC; the National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; and the Division of General Internal Medicine, Denver Health, Denver, Colorado.

Objective: To describe 1) obstetrician-gynecologists' (ob-gyns') perceptions of the frequency of vaccine refusal among pregnant patients and perceived reasons for refusal and 2) ob-gyns' strategies used when encountering vaccine refusal and perceived effectiveness of those strategies.

Methods: We conducted an email and mail survey among a nationally representative network of ob-gyns from March 2016 to June 2016.

Results: The response rate was 69% (331/477). Read More

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http://dx.doi.org/10.1097/AOG.0000000000003005DOI Listing
January 2019
2 Reads

Seroprevalence of diphtheria and pertussis immunoglobulin G among children with pneumonia in Ji'nan, China.

BMC Pediatr 2018 Dec 5;18(1):383. Epub 2018 Dec 5.

Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Background: Vaccination is still one of the most important methods to control and prevent childhood infections including diphtheria and pertussis. This study evaluated the level of diphtheria (DT) and pertussis (PT)-related antibodies among children with pneumonia in Ji'nan, China.

Methods: A total of 484 sera of children from 1 day to 13 years of age were collected from 2014 to 2015 in Ji'nan. Read More

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http://dx.doi.org/10.1186/s12887-018-1337-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282317PMC
December 2018
18 Reads

Use of different combination diphtheria-tetanus-acellular pertussis vaccines does not increase risk of 30-day infant mortality. A population-based linkage cohort study using administrative data from the Australian Childhood Immunisation Register and the National Death Index.

Vaccine 2019 Jan 28;37(2):280-288. Epub 2018 Nov 28.

Discipline of Paediatrics, School of Medicine, University of Adelaide, Adelaide, Australia; Robinson Research Institute, University of Adelaide, South Australia, Australia. Electronic address:

Objective: To determine whether differences in combination DTaP vaccine types at 2, 4 and 6 months of age were associated with mortality (all-cause or non-specific), within 30 days of vaccination.

Design: Observational nationwide cohort study.

Setting: Linked population data from the Australian Childhood Immunisation Register and National Death Index. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.11.025DOI Listing
January 2019
1 Read

Attitudes of physicians concerning vaccines not included in the national immunization schedule.

Turk J Pediatr 2018 ;60(3):290-297

Departments of Social Pediatrics, Gazi University Faculty of Medicine, Ankara, Turkey.

Çataklı T, Duyan-Çamurdan A, Aksakal-Baran FN, Güven AE, Beyazova U. Attitudes of physicians concerning vaccines not included in the national immunization schedule. Turk J Pediatr 2018; 60: 290-297. Read More

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http://www.turkishjournalpediatrics.org/doi.php?doi=10.24953
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http://dx.doi.org/10.24953/turkjped.2018.03.009DOI Listing
January 2018
9 Reads

Paediatric and adult bronchiectasis: Vaccination in prevention and management.

Respirology 2019 Feb 26;24(2):107-114. Epub 2018 Nov 26.

School of Medicine, Griffith University, Gold Coast, QLD, Australia.

Bronchiectasis has received increased attention recently, including an emphasis on preventing infective exacerbations that are associated with disease progression and lung function decline. While there are several bacteria and viruses associated with bronchiectasis, licensed vaccines are only currently available for Streptococcus pneumoniae, Haemophilus influenzae (H. influenzae protein D as a conjugate in a pneumococcal vaccine), Mycobacterium tuberculosis, Bordetella pertussis and influenza virus. Read More

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http://doi.wiley.com/10.1111/resp.13446
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http://dx.doi.org/10.1111/resp.13446DOI Listing
February 2019
9 Reads

The Safety of Influenza and Pertussis Vaccination in Pregnancy in a Cohort of Australian Mother-Infant Pairs, 2012-2015: The FluMum Study.

Clin Infect Dis 2019 Jan;68(3):402-408

Menzies School of Health Research, Charles Darwin University, Tiwi, Northern Territory.

Background: Inactivated influenza vaccine (IIV) and pertussis vaccination are recommended in pregnancy. Limited safety data exist for women who received IIV vaccine during the first trimester of pregnancy or received both vaccines in pregnancy. We assessed adverse birth outcomes between vaccinated and unvaccinated pregnancies. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciy517DOI Listing
January 2019
19 Reads

The impact of timing of maternal influenza immunization on infant antibody levels at birth.

Clin Exp Immunol 2019 Feb 2;195(2):139-152. Epub 2018 Dec 2.

Mucosal Infection and Immunity Group, Section of Virology, Department of Medicine, St Mary's Campus, Imperial College London, UK.

Pregnant women and infants are at an increased risk of severe disease after influenza infection. Maternal immunization is a potent tool to protect both these at-risk groups. While the primary aim of maternal influenza vaccination is to protect the mother, a secondary benefit is the transfer of protective antibodies to the infant. Read More

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http://doi.wiley.com/10.1111/cei.13234
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http://dx.doi.org/10.1111/cei.13234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330660PMC
February 2019
7 Reads

Effect of HIV exposure and timing of antiretroviral therapy initiation on immune memory responses to diphtheria, tetanus, whole cell pertussis and hepatitis B vaccines.

Expert Rev Vaccines 2018 Nov 10:1-10. Epub 2018 Nov 10.

a Department of Science and Technology, Health Sciences , National Research Foundation:Vaccine Preventable Diseases University of the Witwatersrand , Johannesburg , South Africa.

Objectives: We evaluated memory responses and antibody persistence to diphtheria-toxoid, tetanus-toxoid, whole-cell-pertussis (DTwP), and Hepatitis-B vaccines in HIV-unexposed, HIV-exposed-uninfected and HIV-infected children previously randomized to initiate time-limited ART at 6-10 weeks (ART-Immed) or when clinically/immunologically indicated (ART-Def).

Methods: All children received DTwP booster at 15-18 months. Antibodies were measured for pertussis-toxoid, filamentous haemagglutinin (FHA), diphtheria-toxoid, tetanus-toxoid, and hepatitis-B prior to booster, 1-2 weeks post-booster and at 24 months of age. Read More

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https://www.tandfonline.com/doi/full/10.1080/14760584.2019.1
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http://dx.doi.org/10.1080/14760584.2019.1547195DOI Listing
November 2018
16 Reads

Persistence of Antibodies against Diphtheria, Tetanus, Pertussis, and Poliovirus Types I, II, and III Following Immunization with DTaP Combined with Inactivated Wild-Type Polio Vaccine (DTaP-wIPV).

Jpn J Infect Dis 2019 Jan 31;72(1):49-52. Epub 2018 Oct 31.

Kawasaki City Institute for Public Health.

A follow-up serological study was conducted involving 47 subjects who received 4 doses of diphtheria and tetanus toxoids, combined with the acellular pertussis vaccine (DTaP) together with Salk-type inactivated polio vaccine (DTaP-wIPV), until 6 years of age. All antibody levels declined more rapidly than expected within 3 years after the completion of primary vaccination with the 4th booster dose, and titers persisted until 6 years of age. The positive rate of the IgG antibody against pertussis toxin (PT) was 31. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2018.314DOI Listing
January 2019
2 Reads

secretor genotype and susceptibility to infections and chronic conditions in the ALSPAC cohort.

Wellcome Open Res 2018 25;3:65. Epub 2018 Sep 25.

Medical Research Council Integrative Epidemiology Unit, Avon Longitudinal Study of Parents and Children, Population Health Science, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.

The (fucosyltransferase-2) gene determines blood group secretor status. Being homozygous for the inactive "non-secretor" rs601338(A) allele confers resistance to certain infections (e.g. Read More

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https://wellcomeopenresearch.org/articles/3-65/v1
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http://dx.doi.org/10.12688/wellcomeopenres.14636.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171556.2PMC
September 2018
12 Reads

Recommendations to control pertussis prioritized relative to economies: A Global Pertussis Initiative update.

Vaccine 2018 11 15;36(48):7270-7275. Epub 2018 Oct 15.

Department of Pediatrics, University of Pennsylvania and Vaxconsult, Doylestown, PA 19104, USA. Electronic address:

Pertussis is a vaccine-preventable disease that causes morbidity and mortality, particularly in infants and children <5 years of age. The Global Pertussis Initiative (GPI) recommendations represent a systematic evaluation and prioritization of strategies to prevent pertussis-related infant and child deaths, reduce global disease burden and prevent resurgence through vaccination strategies and public health policies at national, regional and local levels. The GPI recommendations are based on clinical trials and observational and surveillance data, which are essential in the planning, implementation and evaluation of vaccination practices and best use of available resources. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X183139
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http://dx.doi.org/10.1016/j.vaccine.2018.10.028DOI Listing
November 2018
15 Reads

Clinically Diagnosing Pertussis-associated Cough in Adults and Children: CHEST Guideline and Expert Panel Report.

Chest 2019 Jan 12;155(1):147-154. Epub 2018 Oct 12.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, UMass Memorial Medical Center, Worcester, MA.

Background: The decision to treat a suspected case of pertussis with antibiotics is usually based on a clinical diagnosis rather than waiting for laboratory confirmation. The current guideline focuses on making the clinical diagnosis of pertussis-associated cough in adults and children.

Methods: The American College of Chest Physicians (CHEST) methodologic guidelines and the Grading of Recommendations, Assessment, Development, and Evaluation framework were used. Read More

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http://dx.doi.org/10.1016/j.chest.2018.09.027DOI Listing
January 2019
1 Read

Association Between Third-Trimester Tdap Immunization and Neonatal Pertussis Antibody Concentration.

JAMA 2018 10;320(14):1464-1470

Infectious Disease Section, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Importance: Immunization with tetanus, diphtheria, and acellular pertussis (Tdap) vaccine is recommended in the United States during weeks 27 through 36 of pregnancy to prevent life-threatening infant pertussis. The optimal gestation for immunization to maximize concentrations of neonatal pertussis toxin antibodies is unknown.

Objective: To determine pertussis toxin antibody concentrations in cord blood from neonates born to women immunized and unimmunized with Tdap vaccine in pregnancy and optimal gestational age for immunization to maximize concentrations of neonatal antibodies. Read More

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http://dx.doi.org/10.1001/jama.2018.14298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233794PMC
October 2018
2 Reads

Impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting.

Vaccine 2018 11 5;36(46):7048-7053. Epub 2018 Oct 5.

Department of Global Health, Emory University, Atlanta, Georgia; Department of Epidemiology, Emory University, Atlanta, Georgia; Department of Pediatrics, Emory University, Atlanta, Georgia; Department of Emory Vaccine Center, Emory University, Atlanta, Georgia.

Background: Maternal vaccines against pertussis are not yet recommended in the developing world. Besides unclear burden estimates, another concern is that transplacental transfer of maternal pertussis antibodies could result in attenuation of the immune response to whole cell pertussis (DTwP) primary vaccination series in infants. This study was taken up to determine whether higher levels of maternal pertussis antibodies attenuate immune response of infants to DTwP vaccination series given at 6-10-14 weeks of age. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.09.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219892PMC
November 2018
9 Reads

Antibody persistence after vaccination of adolescents with monovalent and combined acellular pertussis vaccines containing genetically inactivated pertussis toxin: a phase 2/3 randomised, controlled, non-inferiority trial.

Lancet Infect Dis 2018 Nov 25;18(11):1260-1268. Epub 2018 Sep 25.

BioNet-Asia, Bangjak, Prakanong, Bangkok, Thailand.

Background: The immunogenicity of acellular pertussis vaccines and persistence of immunity after vaccination might be improved by using genetically inactivated pertussis toxin (PTgen) instead of chemically inactivated pertussis toxin (PTchem) because of the preservation of conformational epitopes. We assessed the safety and immunogenicity of two vaccines containing PTgen 1 year after vaccination.

Methods: We did a phase 2/3 non-inferiority, randomised, controlled trial involving 450 adolescents (age 12-17 years) enrolled between July 6, 2015, and Aug 20, 2015. Read More

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http://dx.doi.org/10.1016/S1473-3099(18)30375-XDOI Listing
November 2018
8 Reads

Genetically modified pertussis toxin: a quantum leap?

Lancet Infect Dis 2018 Nov 25;18(11):1169-1171. Epub 2018 Sep 25.

Department of Pediatrics, Vanderbilt University, Nashville, TN, USA.

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http://dx.doi.org/10.1016/S1473-3099(18)30426-2DOI Listing
November 2018
4 Reads

Comparative tetanus antibody response of Nigerian children to diphtheria-pertussis-tetanus and pentavalent vaccines.

Niger Postgrad Med J 2018 Jul-Sep;25(3):137-142

Department of Internal Medicine, University of Uyo, Uyo, Nigeria.

Background: In Nigeria and many parts of the world, the pentavalent vaccine is replacing the diphtheria-pertussis-tetanus (DPT) vaccine in tetanus prevention.

Aims And Objectives: The aim of this study was to compare the anti-tetanus immunoglobulin G (IgG) response of children who received DPT with those who received the pentavalent vaccine.

Subjects And Methods: A cross-sectional survey of anti-tetanus IgG levels in children aged 6 months to 5 years who received DPT and in children who received the pentavalent vaccine. Read More

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http://dx.doi.org/10.4103/npmj.npmj_41_18DOI Listing
September 2018
2 Reads

The anaphylatoxin C3a primes model colonic epithelial cells for expression of inflammatory mediators through Gαi.

Mol Immunol 2018 Nov 24;103:125-132. Epub 2018 Sep 24.

Department of Microbiology & Immunology, Dalhousie University, 5850 College Street, Room 7-C, Halifax, NS, B3H 4R2, Canada; Department of Pediatrics, Dalhousie University, IWK Health Centre, 5850 University Avenue, Halifax, NS, B3K 6R8, Canada. Electronic address:

Multiple studies have identified that complement becomes activated during inflammation of the intestines yet it is unclear what roles the split complement molecules play. The epithelium, in particular, may be impacted and accordingly, we first discovered that colonic cell lines indeed possess the C5aR. Here we examined whether these cells also possess the C3aR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01615890183077
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http://dx.doi.org/10.1016/j.molimm.2018.09.008DOI Listing
November 2018
6 Reads
2.973 Impact Factor

Nasopharyngeal isolates and their clinical impact on young children with asthma: a pilot study.

J Asthma Allergy 2018 12;11:233-243. Epub 2018 Sep 12.

Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates,

Introduction: Respiratory infections have significant effects on childhood asthma. Viral respiratory infections, such as rhinovirus and respiratory syncytial virus are likely to be important in the development and exacerbation of asthma. In this study, we investigated the nasopharyngeal colonization in children with asthma to determine the prevalence of pathogens and their contribution to respiratory symptoms and airway resistance during winter. Read More

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https://www.dovepress.com/nasopharyngeal-isolates-and-their-
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http://dx.doi.org/10.2147/JAA.S169966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140756PMC
September 2018
8 Reads

Performance of the new clinical case definitions of pertussis in pertussis suspected infection and other diagnoses similar to pertussis.

PLoS One 2018 20;13(9):e0204103. Epub 2018 Sep 20.

Department of Epidemiology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.

Background: In an effort to improve the pertussis diagnosis, the Global Pertussis Initiative (GPI) proposed an algorithm of the signs/symptoms of pertussis for three age groups: 0-3 months, 4 months to 9 years, and ≥10 years of age.

Methods: We evaluated the accuracy of the clinical case definitions for pertussis proposed by the GPI using laboratory-confirmed pertussis as a reference standard for four groups: clinically suspected pertussis without comorbidity; asthma exacerbation; allergic constitution, and other diagnoses (bronchitis, bronchiolitis, laryngitis, and tracheitis). We included only patients who fulfilled one or more criteria of clinical case definitions for the age groups (0-3 months, 4 months-9 years, and ≥10 years of age). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204103PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147443PMC
September 2018
4 Reads

Reactogenicity and immunogenicity of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant and nonpregnant women.

Vaccine 2018 10 13;36(42):6354-6360. Epub 2018 Sep 13.

Department of Pediatrics, Vanderbilt University, Nashville, TN, USA.

Objective: Tetanus toxoid, reduced diphtheria toxoid, and acellular pertusiss (Tdap) vaccine is recommended during each pregnancy, regardless of prior receipt. Data on reactogenicity and immunogenicity, particularly after repeated Tdap, are limited. We compared local injection-site and systemic reactions and serologic response following Tdap in (1) pregnant and nonpregnant women and (2) pregnant women by self-reported prior Tdap receipt. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.07.012DOI Listing
October 2018
8 Reads

Immunogenicity and Safety of Monovalent Acellular Pertussis Vaccine at Birth: A Randomized Clinical Trial.

JAMA Pediatr 2018 Nov;172(11):1045-1052

National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Westmead, New South Wales, Australia.

Importance: An alternative option to maternal vaccination to prevent severe pertussis in infants is vaccination at birth. Data are needed on the immunogenicity and safety of a birth dose of monovalent acellular pertussis (aP) vaccine.

Objective: To compare IgG antibody responses to vaccine antigens at 6, 10, 24, and 32 weeks of age between newborn infants receiving the aP vaccine and hepatitis B vaccine (HBV) or HBV alone. Read More

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http://archpedi.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamapediatrics.2018.2349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248137PMC
November 2018
14 Reads

Seroprevalence of Maternal and Cord Antibodies Specific for Diphtheria, Tetanus, Pertussis, Measles, Mumps and Rubella in Shunyi, Beijing.

Sci Rep 2018 Aug 29;8(1):13021. Epub 2018 Aug 29.

Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Maternal antibodies contribute to the protection of young infants from infectious diseases during the early life. However, vaccinations for women of child-bearing age are not routine in China. Therefore, we investigated the level of protective immunity against vaccine preventable diseases in pregnant women and newborns in China. Read More

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http://dx.doi.org/10.1038/s41598-018-31283-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115429PMC
August 2018
7 Reads
5.080 Impact Factor

Safety and efficacy of DTaP-IPV vaccine use in healthcare workers for prevention of pertussis.

Vaccine 2018 09 25;36(40):5935-5939. Epub 2018 Aug 25.

Department of Lifetime Clinical Immunology, Graduate School, Tokyo Medical and Dental University, Japan. Electronic address:

Pertussis can be fatal for infants. The best way to prevent infant pertussis is to promote adult immunization. However, Tdap has not been licensed in Japan, so we investigated the effect and safety of the DTaP-IPV vaccine instead. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.08.047DOI Listing
September 2018
4 Reads

Comparison of adverse events following immunisation with acellular and whole-cell pertussis vaccines: A systematic review.

Vaccine 2018 09 22;36(40):6007-6016. Epub 2018 Aug 22.

Vaccines for Africa Initiative, University of Cape Town, South Africa; Department of Paediatrics & Child Health, Groote Schuur Hospital, University of Cape Town, South Africa. Electronic address:

Introduction: Two types of vaccines are currently licensed for use against pertussis: whole-cell (wP) and acellular pertussis (aP). There is evidence that wP confers more durable immunity than aP, however wP has been more frequently associated with adverse events following immunisation (AEFI). A comparison of the frequency of AEFI with the first doses of wP and aP has not yet been clearly documented. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X183113
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http://dx.doi.org/10.1016/j.vaccine.2018.08.022DOI Listing
September 2018
16 Reads

Primary Ovarian Insufficiency and Adolescent Vaccination.

Pediatrics 2018 Sep 21;142(3). Epub 2018 Aug 21.

Immunization Safety Office, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Published case series have suggested a potential association between human papillomavirus (HPV) vaccination and primary ovarian insufficiency (POI). We describe POI incidence and estimate POI risk after HPV; tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis, adsorbed (Tdap); inactivated influenza (II); and meningococcal conjugate (MenACWY) vaccination.

Methods: We searched Kaiser Permanente Northwest electronic health records for outpatient diagnoses suggestive of POI in female patients aged 11 to 34 years between 2006 and 2014. Read More

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http://dx.doi.org/10.1542/peds.2018-0943DOI Listing
September 2018
18 Reads

Adherence to pneumococcal conjugate vaccination schedule and uptake rate as compared to the established diphtheria-tetanus-acellular pertussis vaccination in Cyprus.

Vaccine 2018 09 14;36(38):5685-5691. Epub 2018 Aug 14.

Third Department of Paediatrics, National and Kapodistrian University of Athens, General University Hospital "ATTIKON", Athens, Greece. Electronic address:

Background: Pneumococcus is a common cause of invasive and non-invasive infections in children. In areas with high vaccination coverage, universal infant vaccination with conjugated pneumococcal vaccine (PCV) has significantly decreased the incidence of vaccine type nasopharyngeal carriage and invasive pneumococcal disease. The aim of this study is to examine immunization coverage rate and timely administration of the recently introduced PCV and compare to the established diphtheria-tetanus-acellular pertussis vaccine (DTaP) with similar schedule. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.08.021DOI Listing
September 2018
7 Reads

Discrepancies Between US Food and Drug Administration Vaccine Licensure Indications and Advisory Committee on Immunization Practices Recommendations: Provider Knowledge and Attitudes.

Clin Ther 2018 Aug 11;40(8):1308-1319.e16. Epub 2018 Aug 11.

Division of Pediatric Infectious Disease, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia.

Purpose: In the United States, the Center for Biologics Evaluation and Research at the US Food and Drug Administration (FDA) is responsible for licensure of vaccines. The Advisory Committee on Immunization Practices (ACIP) is a federal advisory committee that provides guidance to the Centers for Disease Control and Prevention (CDC) on use of vaccines. Discrepancies between FDA licensure indications and ACIP/CDC vaccine recommendations exist, challenging health care providers. Read More

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http://dx.doi.org/10.1016/j.clinthera.2018.07.004DOI Listing
August 2018
2 Reads

Prenatal Tetanus, Diphtheria, Acellular Pertussis Vaccination and Autism Spectrum Disorder.

Pediatrics 2018 Sep 13;142(3). Epub 2018 Aug 13.

Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.

: media-1vid110.1542/5803567555001PEDS-VA_2018-0120 BACKGROUND: Increasing vaccination of pregnant women makes it important to assess safety events potentially linked to prenatal vaccination. This study investigates the association between prenatal tetanus, diphtheria, acellular pertussis (Tdap) vaccination and autism spectrum disorder (ASD) risk in offspring. Read More

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http://dx.doi.org/10.1542/peds.2018-0120DOI Listing
September 2018
2 Reads

Could this be whooping cough?

Emerg Med J 2018 Oct 10;35(10):639-642. Epub 2018 Aug 10.

Emergency Department, Whiston Hospital, Prescot, UK.

Whooping cough is a notifiable bacterial respiratory infection caused by It may produce serious disease, especially in immunocompromised individuals and very young children. The number of reported cases increases in the winter months and the incidence peaks every 4-5 years. However, this periodicity is variable and is inconsistent between different geographical regions. Read More

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http://dx.doi.org/10.1136/emermed-2018-207792DOI Listing
October 2018
3 Reads