2,147 results match your criteria Pediatrics Pertussis


A previously treated severe haemophilia A patient developed high-titre inhibitor after vaccinations.

Int J Immunopathol Pharmacol 2020 Jan-Dec;34:2058738420934618

Hemophilia Work Group, Hematology Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

The factor VIII (FVIII)-neutralizing antibody (inhibitor) seen in 25%-30% of patients with severe haemophilia A (SHA). Vaccination is a non-genetic risk factor of inhibitor development as 'danger signal' which may provide a pro-inflammatory microenvironment to increase FVIII immunogenicity. We reported a previously treated SHA patient postponed the first vaccination to 15-month age received diphtheria-pertussis-tetanus intramuscularly. Read More

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http://dx.doi.org/10.1177/2058738420934618DOI Listing

Designing a multi-component intervention (P3-MumBubVax) to promote vaccination in antenatal care in Australia.

Health Promot J Austr 2020 Jul 3. Epub 2020 Jul 3.

Murdoch Children's Research Institute, Parkville, Australia.

Issue addressed Coverage of maternal influenza and pertussis vaccines remains suboptimal in Australia, and pockets of low childhood vaccine coverage persist nationwide. Maternal vaccine uptake is estimated to be between 35% and 60% for influenza vaccination and between 65% and 80% for pertussis vaccination. Australian midwives are highly trusted and ideally-placed to discuss vaccines with expectant parents, but there are no evidence-based interventions to optimise these discussions and promote maternal and childhood vaccine acceptance in the Australian public antenatal setting. Read More

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http://dx.doi.org/10.1002/hpja.382DOI Listing

Suboptimal uptake of meningococcal vaccines among older adolescents: Barriers, solutions, and future research directions.

Hum Vaccin Immunother 2020 Jul 2:1-5. Epub 2020 Jul 2.

Yale School of Medicine, Department of Pediatrics , New Haven, CT, USA.

Over the past 15 y, several vaccines have been added to the recommended immunization schedule for adolescents in the United States. In addition to annual influenza vaccination, the Advisory Committee on Immunization Practices recommends tetanus, diphtheria, and pertussis (Tdap), meningococcal conjugate (MenACWY), and human papillomavirus (HPV) vaccine for routine administration at ages 11-12 y, and a second dose of MenACWY at age 16. A vaccine against meningococcal disease caused by serogroup B (MenB) is also available and recommended for shared clinical decision-making. Read More

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http://dx.doi.org/10.1080/21645515.2020.1754052DOI Listing

Active surveillance of acute paediatric hospitalisations demonstrates the impact of vaccination programmes and informs vaccine policy in Canada and Australia.

Euro Surveill 2020 06;25(25)

The IMPACT and PAEDS investigators are acknowledged at the end of this article.

Sentinel surveillance of acute hospitalisations in response to infectious disease emergencies such as the 2009 influenza A(H1N1)pdm09 pandemic is well described, but recognition of its potential to supplement routine public health surveillance and provide scalability for emergency responses has been limited. We summarise the achievements of two national paediatric hospital surveillance networks relevant to vaccine programmes and emerging infectious diseases in Canada (Canadian Immunization Monitoring Program Active; IMPACT from 1991) and Australia (Paediatric Active Enhanced Disease Surveillance; PAEDS from 2007) and discuss opportunities and challenges in applying their model to other contexts. Both networks were established to enhance capacity to measure vaccine preventable disease burden, vaccine programme impact, and safety, with their scope occasionally being increased with emerging infectious diseases' surveillance. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2020.25.25.1900562DOI Listing

Determining Which of Several Simultaneously Administered Vaccines Increase Risk of an Adverse Event.

Drug Saf 2020 Jul 1. Epub 2020 Jul 1.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA, 02120, USA.

Introduction: Childhood immunization schedules often involve multiple vaccinations per visit. When increased risk of an adverse event is observed after simultaneous (same-day) vaccinations, it can be difficult to ascertain which triggered the adverse event. This methods paper discusses a systematic process to determine which of the simultaneously administered vaccine(s) are most likely to have caused an observed increase in risk of an adverse event. Read More

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http://dx.doi.org/10.1007/s40264-020-00967-8DOI Listing

[Children's pertussis immunization strategy in China].

Authors:
Q R Su J K Deng

Zhonghua Er Ke Za Zhi 2020 Jul;58(7):615-617

Department of Infectious Diseases, Shenzhen Children's Hospital, Shenzhen 518038, China.

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http://dx.doi.org/10.3760/cma.j.cn112140-20200509-00483DOI Listing

Impact of pertussis-specific IgA, IgM, and IgG antibodies in mother's own breast milk and donor breast milk during preterm infant digestion.

Pediatr Res 2020 Jun 29. Epub 2020 Jun 29.

Nutrition Program, School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA.

Background: The survival of antibody isotypes specific to pertussis toxin (PT) and filamentous hemagglutinin (FHA) from mother's own milk (MBM) and donor breast milk (DBM) during preterm infant digestion was investigated.

Methods: Feed, gastric, and stool samples were collected from 20 preterm mother-infant pairs at 8-9 days and 21-22 days postpartum. Samples were analyzed via ELISA for anti-FHA or anti-PT immunoglobulin A (IgA), IgM, and IgG. Read More

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http://dx.doi.org/10.1038/s41390-020-1031-2DOI Listing

Current regional consensus recommendations on infant vaccination of the Latin American pediatric infectious diseases society (SLIPE).

Expert Rev Vaccines 2020 Jun 25:1-7. Epub 2020 Jun 25.

Pediatrics Department, Centro Médico UCE , Santo Domingo, República Dominicana.

Introduction: The 1st Regional Experts on Infant Vaccination (REIV) meeting generated updated consensus recommendations to improve the control of various major vaccine preventable diseases (VPD) in Latin America.

Areas Covered: Workshops highlighted recent changes in immunization schedules within the region, experience of countries incorporating combined acellular pertussis vaccines schedules and parenteral inactivated polio vaccine (IPV). The need to definitively replace oral polio vaccine (OPV) by IPV, and potential benefits of introducing new combined vaccines, were extensively discussed. Read More

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http://dx.doi.org/10.1080/14760584.2020.1775078DOI Listing

Control of vaccine preventable diseases in Australian infants: reviewing a decade of experience with DTPa-HBV-IPV/Hib vaccine.

Hum Vaccin Immunother 2020 Jun 23:1-15. Epub 2020 Jun 23.

Vaccine and Immunisation Research Group (Virgo), University of Melbourne, School of Population and Global Health and Murdoch Children's Research Institute , Melbourne, Australia.

The combined vaccine against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, and b (DTPa-HBV-IPV/Hib, Infanrix Hexa, GSK) has been used for childhood immunization in Australia according to a two-, four-, six-month schedule since 2009. We reviewed data available in the Australian National Notifiable Diseases Surveillance System, annual vaccination coverage reports, the Database of Adverse Event Notifications, and peer-reviewed literature to assess vaccine coverage rates, incidence of all six vaccine preventable diseases, and the safety profile of DTPa-HBV-IPV/Hib vaccine in Australian infants over a period of ten years of exclusive use. Between 2009 and 2018 vaccine coverage for infants aged 12 months increased from 91. Read More

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http://dx.doi.org/10.1080/21645515.2020.1764826DOI Listing

Extending Timing of Immunization Against Pertussis During Pregnancy and Protection of Premature Infants from Whooping Cough Disease.

Authors:
Bahaa Abu-Raya

Clin Infect Dis 2020 Jun 22. Epub 2020 Jun 22.

Division of Infectious Diseases, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1093/cid/ciaa831DOI Listing

Routine vaccination during covid-19 pandemic response.

BMJ 2020 06 16;369:m2392. Epub 2020 Jun 16.

UCL Great Ormond Street Institute of Child Health, London, UK.

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http://dx.doi.org/10.1136/bmj.m2392DOI Listing

Paediatric Active Enhanced Disease Surveillance (PAEDS) 2017 and 2018: Prospective hospital-based surveillance for serious paediatric conditions.

Commun Dis Intell (2018) 2020 06 15;44. Epub 2020 Jun 15.

Director, National Centre for Immunisation Research and Surveillance, Kids Research Institute, The Children's Hospital at Westmead, New South Wales; Professor, Discipline of Child and Adolescent Health, University of Sydney, New South Wales; Staff Specialist, Department of Microbiology and Infectious Diseases, The Children's Hospital at Westmead, New South Wales.

Introduction: The Paediatric Active Enhanced Disease Surveillance (PAEDS) network is a hospital-based active surveillance system employing prospective case ascertainment for selected serious childhood conditions, particularly vaccine-preventable diseases and potential adverse events following immunisation (AEFI). This report presents surveillance data for 2017 and 2018.

Methods: Specialist nurses screened hospital admissions, emergency department (ED) records, laboratory and other data on a daily basis in seven paediatric tertiary referral hospitals across Australia to identify children with the conditions under surveillance. Read More

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http://dx.doi.org/10.33321/cdi.2020.44.49DOI Listing

Effectiveness of rapid multiplex polymerase chain reaction for early diagnosis and treatment of pertussis.

J Microbiol Immunol Infect 2020 May 28. Epub 2020 May 28.

Department of Pediatrics, College of Medicine, Yeungnam University, Daegu, South Korea. Electronic address:

Background: Pertussis, is an infectious respiratory disease caused by Bordetella pertussis. The incidence of pertussis has been increasing in South Korea to due to waning vaccine-induced immunity. Culture has a low sensitivity and a long turnaround time (TAT). Read More

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http://dx.doi.org/10.1016/j.jmii.2020.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255742PMC

Active SMS-based surveillance of adverse events following immunisation with influenza and pertussis-containing vaccines in Australian pregnant women using AusVaxSafety.

Vaccine 2020 Jun 2;38(31):4892-4900. Epub 2020 Jun 2.

National Centre for Immunisation Research and Surveillance, Children's Hospital at Westmead, Westmead, New South Wales, Australia; Discipline of Child and Adolescent Health, University of Sydney, Sydney, Australia; Department of Microbiology and Infectious Disease, Children's Hospital at Westmead, Westmead, New South Wales, Australia. Electronic address:

Background: Maternal immunisation is important to protect both mother and baby, but safety concerns can lead to low uptake. AusVaxSafety participant-based surveillance actively monitors adverse events following immunisation (AEFI) in Australia. We aimed to analyse AEFI in the days following vaccination with seasonal inactivated influenza vaccine (IIV) and/or reduced antigen diphtheria-tetanus-acellular pertussis vaccine (dTpa) in pregnant women in Australia. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.04.056DOI Listing

Efficiency of placental transfer of vaccine-elicited antibodies relative to prenatal Tdap vaccination status.

Vaccine 2020 Jun 29;38(31):4869-4876. Epub 2020 May 29.

Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA; Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. Electronic address:

Administration of vaccines during pregnancy provides maternal protection against infectious diseases. This protection is extended to their infants during the first months of life, as pathogen-specific antibodies formed in response to maternal vaccination are transferred across the placenta to the fetus. Notably, Tdap (tetanus-diphtheria-acellular pertussis) vaccination booster is routinely administered to pregnant women both to prevent neonatal tetanus and to ensure that infants have protective levels of pertussis antibodies until they are able to establish their own vaccine-induced levels. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.05.036DOI Listing

An infant who suffered seizures many times after pentavalent vaccination: A case report.

North Clin Istanb 2020 9;7(3):302-304. Epub 2020 Apr 9.

Department of Pediatric Neurology, Ankara Yildirim Beyazit University, Yenimahalle Training and Research Hospital, Ankara, Turkey.

Although rare, serious adverse effects may be seen after vaccination. Especially, the whole-cell pertussis vaccine has been held responsible for neurological side effects, as the most important problem in vaccination. With the advancement in vaccination technologies, whole-cell pertussis vaccine has been replaced by acellular pertussis vaccine, and neurological side effects have been significantly reduced. Read More

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http://dx.doi.org/10.14744/nci.2019.50375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251270PMC

Highlights of the 12th International Bordetella Symposium.

Clin Infect Dis 2020 May 28. Epub 2020 May 28.

Laboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium.

To commemorate the 100th anniversary of the Nobel prize being awarded to Jules Bordet, the discoverer of Bordetella pertussis, the 12th International Bordetella Symposium was held from April 9-12, 2019 at the Université Libre de Bruxelles, where Jules Bordet studied and was Professor of Microbiology. The symposium attracted more than 300 Bordetella experts from 34 countries. They discussed the latest epidemiologic data and clinical aspects of pertussis, Bordetella biology and pathogenesis, immunology and vaccine development, and genomics and evolution. Read More

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http://dx.doi.org/10.1093/cid/ciaa651DOI Listing

Infant antibody levels following 10-valent pneumococcal-protein D conjugate and DTaP-Hib vaccinations in the first year of life after maternal Tdap vaccination: An open-label, parallel, randomised controlled trial.

Vaccine 2020 Jun 21;38(29):4632-4639. Epub 2020 May 21.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands. Electronic address:

Background: Maternal antibody levels after Tdap vaccination during pregnancy may affect infant primary antibody responses to pertussis, Tetanus toxoid (TT), Diphtheria toxoid (DT) vaccinations and pneumococcal vaccines with diphtheria toxin mutants like CRM197 as carrier protein.

Methods: Mothers were recruited in an open label randomised parallel controlled trial in 2014-2016 through midwifes. They received Tdap [Boostrix] at 30-32 weeks of pregnancy (n = 58) or within 48 h after delivery (n = 60). Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.04.001DOI Listing

[Access to complementary tests for the diagnosis of infectious diseases in primary care paediatric clinics].

An Pediatr (Barc) 2020 May 16. Epub 2020 May 16.

CS de Polanco, Cantabria, España.

Introduction: The performing of complementary tests in infectious processes can increase the diagnostic precision, the adequacy of treatments, as well as determining the epidemiology and pattern of bacterial resistance of the community. The Infectious Pathology Group of the Spanish Association of Primary Care Paediatrics (GPI-AEPap) has designed this study in order to determine the availability of complementary tests (CT) for paediatricians working in Primary Care of the public health system as well as their results.

Material And Methods: Observational cross-sectional descriptive national study was carried out using a voluntary self-report questionnaire distributed online to all AEPap members and to the subscribers of the PEDIAP distribution list between the months of April and May 2017. Read More

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http://dx.doi.org/10.1016/j.anpedi.2020.03.015DOI Listing

Perinatal health care providers' approaches to recommending and providing pertussis vaccination in pregnancy: a qualitative study.

CMAJ Open 2020 Apr-Jun;8(2):E377-E382. Epub 2020 May 15.

Vaccine Evaluation Center (Mijović, Greyson, Gemmell, Bettinger), BC Children's Hospital Research Institute, University of British Columbia; Department of Pediatrics (Mijović, Bettinger), Faculty of Medicine, University of British Columbia, Vancouver, BC; Department of Communication (Greyson), University of Massachusetts, Amherst, Mass.; Quebec National Institute of Public Health (Trottier, Vivion, Dubé), Québec, Que.; Department of Pediatrics (Graham), Faculty of Medicine, Dalhousie University, Halifax, NS; Department of Anthropology (Dubé), Université Laval, Québec, Que.

Background: In 2018, the Canadian National Advisory Committee on Immunization and the Society of Obstetricians and Gynaecologists of Canada recommended a single dose of tetanus toxoid, reduced diphtheria toxoid and reduced acellular pertussis (Tdap) vaccine in every pregnancy. To understand how perinatal health care providers in Canada are translating recent recommendations for universal antenatal Tdap vaccine into routine clinical practice, we examined health care providers' perceptions of what influences their ability to recommend and provide Tdap vaccine consistently to pregnant women.

Methods: Between June 2018 and July 2019, we conducted semistructured telephone interviews with perinatal health care providers (nurses, midwives, family physicians and obstetricians) from 5 provinces (British Columbia, Manitoba, Ontario, Quebec and Nova Scotia) representing diverse educational experiences, practice settings and models of care. Read More

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http://dx.doi.org/10.9778/cmajo.20190215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239636PMC

Review of pediatric encephalitis and encephalopathy cases following immunization reported to the Canadian Immunization Monitoring Program Active (IMPACT) from 1992 to 2012.

Vaccine 2020 Jun 12;38(28):4457-4463. Epub 2020 May 12.

Department of Pediatrics, Dalhousie University and Canadian Center for Vaccinology, IWK Health Centre, Halifax, NS, Canada. Electronic address:

Background: Neurological adverse events following immunization (AEFI) remain poorly characterized. Our objective was to describe pediatric acute and chronic encephalopathy and encephalitis cases following immunization reported via active sentinel surveillance from 1992 to 2012.

Methods: This case series provides a descriptive analysis of encephalopathy/encephalitis admissions reported to the Canadian Immunization Monitoring Program ACTive (IMPACT). Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.04.035DOI Listing

Pertussis vaccination in mixed markets: Recommendations from the Global Pertussis Initiative.

Int J Infect Dis 2020 May 12;96:482-488. Epub 2020 May 12.

Krefeld, Germany. Electronic address:

The Global Pertussis Initiative is an expert scientific forum that publishes consensus recommendations concerning pertussis for many regions of the world. Here, we give recommendations for the primary vaccination of infants in those countries where whole-cell pertussis (wP)- and acellular pertussis (aP)-containing combination vaccines are used in parallel. A selective literature review was performed concerning the influence on safety, immunogenicity, and effectiveness of mixing wP- and aP-containing vaccines for primary immunization of infants. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.04.081DOI Listing

Seroprevalence of antibodies against diphtheria, tetanus, and pertussis among healthy Thai adolescents.

Int J Infect Dis 2020 May 6;96:422-430. Epub 2020 May 6.

Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand; Clinical and Molecular Epidemiology of Emerging and Re-emerging Infectious Diseases Cluster, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. Electronic address:

Objective: To determine the seroprevalence of antibodies against of diphtheria, tetanus, and pertussis among Thai adolescents.

Methods: A cross-sectional study was conducted among Thai adolescents aged 11-20 years who had completed five doses of diphtheria, tetanus, and pertussis (DTP)-containing vaccine during childhood, either diphtheria toxoid, tetanus toxoid, whole-cell pertussis (DTwP) or diphtheria toxoid, tetanus toxoid, acellular pertussis (DTaP) vaccine. Protective antibodies against diphtheria, tetanus, and pertussis were defined as anti-diphtheria toxoid IgG ≥0. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.04.088DOI Listing

Allele frequencies of Bordetella pertussis virulence-associated genes identified from pediatric patients with severe respiratory infections.

J Infect Chemother 2020 Jul 22;26(7):765-768. Epub 2020 Apr 22.

Division of Infectious Diseases, Department of Medical Specialties, National Center for Child Health and Development, Tokyo, Japan. Electronic address:

Bordetella pertussis (B. pertussis) infection occasionally causes severe respiratory infections in children. Potential association between virulence-associated gene alleles and severe clinical outcomes has been suggested; however, frequencies of these alleles in pediatric patients with severe pertussis have not been clarified. Read More

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http://dx.doi.org/10.1016/j.jiac.2020.02.016DOI Listing

Antibodies to measles, mumps, and rubella virus in Thai children after two-dose vaccination at 9 months and 2.5 years: A longitudinal study.

Vaccine 2020 May 21;38(24):4016-4023. Epub 2020 Apr 21.

Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Academy of Science, Royal Society of Thailand, Bangkok, Thailand. Electronic address:

Introduction: Thailand changed the schedule of childhood measles-mumps-rubella (MMR) vaccination in 2014, moving the second dose from the age of 6 years to 2.5 years. There are currently no data on antibody responses to the MMR vaccine since this recommendation. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.04.013DOI Listing

Seroprevalences of antibodies against pertussis, diphtheria, tetanus, measles, mumps and rubella: A cross-sectional study in children following vaccination procedure in Guangzhou, China.

Vaccine 2020 May 19;38(23):3960-3967. Epub 2020 Apr 19.

Department of Pediatrics, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China. Electronic address:

This study investigated the concentrations and seroprevalence of immunoglobulin G (IgG) antibodies against pertussis, diphtheria, tetanus, measles, mumps and rubella among children in Guangzhou, China. We conducted a cross-sectional study focusing on the post-vaccination immune statuses of children on scheduled immunisation. Human IgG antibody against six diseases were measured using commercial enzyme-linked immunosorbent assay kits. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.03.056DOI Listing

Vaccination during pregnancy: Canadian maternity care providers' opinions and practices.

Hum Vaccin Immunother 2020 Apr 9:1-11. Epub 2020 Apr 9.

Society of Obstetricians and Gynaecologists of Canada, Ottawa, Canada.

A number of countries have implemented vaccination in pregnancy as a strategy to reduce the burden of influenza and pertussis. The aim of this study was to assess the involvement of Canadian maternity care providers in administration of vaccines to their pregnant patients. A cross-sectional web-based survey was sent to family physicians, obstetricians-gynecologists, midwives, pharmacists, and nurses. Read More

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http://dx.doi.org/10.1080/21645515.2020.1735225DOI Listing

No association between HPV vaccination and infertility in U.S. females 18-33 years old.

Vaccine 2020 May 3;38(24):4038-4043. Epub 2020 Apr 3.

University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Clinical Sciences Center, 600 Highland Ave, Madison, WI 53792, USA. Electronic address:

Background: Human papillomavirus (HPV) vaccines have been recommended as primary prevention of HPV-related cancers for over 10 years in the United States, and evidence reveals decreased incidence of HPV infections following vaccination. However, concerns have been raised that HPV vaccines could decrease fertility. This study examined the relationship between HPV immunization and self-reported infertility in a nationally representative sample. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.03.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255493PMC

Prevalence of B. pertussis infection in children with clinically suspected pertussis.

J Microbiol Immunol Infect 2020 Mar 14. Epub 2020 Mar 14.

Department of Clinical Laboratory, Children's Hospital of Soochow University, China.

Background: Pertussis is an important cause of hospitalization in children. Limited data on pertussis have been reported from China. The aim of this study was to characterize clinically suspected pertussis attributable to Bordetella pertussis among children and determine factors associated with longer duration of hospital stay in B. Read More

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http://dx.doi.org/10.1016/j.jmii.2020.03.006DOI Listing
March 2020
2.349 Impact Factor

A Qualitative Study of Views and Experiences of Women and Health Care Professionals about Free Maternal Vaccinations Administered at Community Pharmacies.

Vaccines (Basel) 2020 Mar 29;8(2). Epub 2020 Mar 29.

Department of Paediatrics: Child and Youth Health, University of Auckland, 2 Park Rd, Auckland 1023, New Zealand.

A policy to extend funding of maternal pregnancy influenza and pertussis vaccinations to community pharmacies could address low pregnancy vaccine uptake. The policy has been implemented in one region in New Zealand. This study explored the views and experiences of women eligible for the vaccines and health care professionals regarding funded maternal vaccinations in pharmacy. Read More

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http://dx.doi.org/10.3390/vaccines8020152DOI Listing

[Coverage rate and adverse reactions of National Immunization Program vaccines in children with spinal muscular atrophy: a cross-sectional retrospective cohort study].

Zhonghua Er Ke Za Zhi 2020 Apr;58(4):308-313

Department of Medical Genetics, Capital Institute of Pediatrics, Beijing 100020, China.

To investigate the coverage rate and the adverse reactions of National Immunization Program vaccines in children with spinal muscular atrophy (SMA). A cross-sectional retrospective cohort study was carried out from July 2016 to June 2019, 192 children (116 boys and 76 girls) with SMA registered by Capital Institute of Pediatrics and 191 healthy children (115 boys and 76 girls) vaccinated in Chaoyang Olympic Village Community Health Service Center from July 2016 to December 2018 were included. Questionnaire survey was designed to investigate the vaccination coverage rate and associated adverse events. Read More

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http://dx.doi.org/10.3760/cma.j.cn112140-20200108-00016DOI Listing

Multiplex Point-of-Care Tests for the Determination of Antibodies after Acellular Pertussis Vaccination.

Diagnostics (Basel) 2020 Mar 27;10(4). Epub 2020 Mar 27.

Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland.

Most of the current serological diagnosis of pertussis is based on pertussis toxin (PT) IgG antibodies and does not differentiate between vaccination and infection-induced antibodies. PT is included in all of acellular pertussis vaccines available in the world. Multiplex testing of non-vaccine antigen-related antibodies has the potential to improve the diagnostic outcome of these assays. Read More

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http://dx.doi.org/10.3390/diagnostics10040187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235718PMC

[Correlation of behavioral performance with expressions of substance P and neurokinin-1 receptor in the L5-S2 spinal cord of chronic prostatitis rats].

Zhonghua Nan Ke Xue 2019 Jun;25(6):489-495

Faculty of Basic Sciences, School of Medicine, Pingdingshan College, Pingdingshan, Henan 467000, China.

Objective: To investigate the correlation between the behavioral performance and the expressions of substance P (SP) and neurokinin-1 receptor (NK-1R) in the posterior horn of the L5-S2 spinal cord in rats with chronic prostatitis (CP).

Methods: A CP model was made in 30 adult male SD rats by intraperitoneal injection of 0.5 ml dyphtheria pertussis tetanus (DPT) vaccine and mixed solution of 1 ml prostatein extract and complete adjuvant in a 1∶1 ratio, and another 10 rats were injected with the same volume of normal saline as controls. Read More

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A live-vaccine-last schedule: saving an extra million lives a year?

Authors:
Frank Shann

Clin Infect Dis 2020 Mar 18. Epub 2020 Mar 18.

Department of Paediatrics, University of Melbourne, Australia.

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http://dx.doi.org/10.1093/cid/ciaa292DOI Listing

Dynamics of pertussis toxin IgG after symptomatic pertussis in children and adults.

Vaccine 2020 Apr 11;38(16):3196-3200. Epub 2020 Mar 11.

Department of Microbiology, University of Tartu, Tartu, Estonia.

Background And Aim: The knowledge of dynamics of pertussis toxin (PT)-IgG after pertussis and the appropriate diagnostic cut-off value is limited. We aimed to describe the dynamics of PT-IgG in children and adults up to three years after symptomatic pertussis.

Methods: Patients with persistent cough of unknown aetiology were prospectively enrolled 2012-2014. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.02.080DOI Listing

Congenital nephrotic syndrome as a complication of whooping cough: a case report.

Oxf Med Case Reports 2020 Feb 28;2020(2):omaa007. Epub 2020 Feb 28.

Resident doctor at the Department of Pediatrics, Aleppo University Hospital, Aleppo, Syria.

Bordetella organisms are responsible for whooping cough, which is an extremely contagious respiratory illness with substantial morbidity in infants. It is also considered one of the 10 predominant reasons for childhood decease globally, particularly before vaccination was available. Congenital nephrotic syndrome (CNS) presents within the first 3 months of life. Read More

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http://dx.doi.org/10.1093/omcr/omaa007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048075PMC
February 2020

[Progress in etiology, pathogenesis and clinical characteristics of pertussis syndrome].

Authors:
J Y Cao J H Pan

Zhonghua Er Ke Za Zhi 2020 Feb;58(2):158-161

Department of Pediatrics, Anhui Provincial Hospital, Hefei 230001, China.

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2020.02.020DOI Listing
February 2020

Factors associated with referring close contacts to an app with individually-tailored vaccine information.

Vaccine 2020 Mar 22;38(13):2827-2832. Epub 2020 Feb 22.

Department of International Health, Johns Hopkins University Bloomberg School of Public Health, United States; Department of Health, Behavior and Society, Johns Hopkins University Bloomberg School of Public Health, United States; Institute for Vaccine Safety, Johns Hopkins University Bloomberg School of Public Health, United States.

Background: Infants too young to be fully vaccinated are vulnerable to potentially deadly influenza and pertussis infections. The cocooning strategy limits this risk by vaccinating those likely to interact with the infant and mother during this vulnerable time, such as close friends and family members. Distribution of accurate and accessible vaccine information through existing social networks could be an important tool in increasing vaccine confidence and coverage. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.02.019DOI Listing

Comparison of the clinical and laboratory characteristics of pertussis or viral lower respiratory tract infections.

J Infect Dev Ctries 2019 09 30;13(9):823-830. Epub 2019 Sep 30.

Department of Pediatric Infectious Diseases, Faculty of Medicine, Ankara University, Ankara, Turkey .

Introduction: Whooping cough-like respiratory tract infections (WCLRTI) caused by factors other than the Bordetella pertussis are available. Clinical picture is difficult to differentiate between the B. pertussis and viral respiratory infections. Read More

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http://dx.doi.org/10.3855/jidc.10558DOI Listing
September 2019

Seroprevalence of Bordetella pertussis antibodies and anti-pertussis antibody response after a single dose of reduced-antigen combined diphtheria, tetanus, and acellular pertussis vaccine (Tdap) in pregnant Thai women.

Vaccine 2020 Mar 16;38(12):2725-2733. Epub 2020 Feb 16.

Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Maternal immunization with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) has recently been implemented to prevent infant pertussis. Tdap is still not routinely recommended in Thailand, and there are limited data to support or challenge this strategy.

Objectives: The primary aim was to determine the seroprevalence of anti-pertussis toxin antibodies (anti-PT IgG) among pregnant Thai women. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.01.074DOI Listing

Waning vaccine immunity and vaccination responses in children treated for acute lymphoblastic leukemia: A Canadian Immunization Research Network Study.

Clin Infect Dis 2020 Feb 18. Epub 2020 Feb 18.

Departments of Pediatrics and Microbiology & Immunology and the Canadian Center for Vaccinology, Dalhousie University, and the IWK Health Centre.

Background: There is no uniform guideline for post-chemotherapy vaccination of children with acute lymphoblastic leukemia (ALL). We evaluated waning immunity to 14 pneumococcal serotypes, pertussis toxin (PT), tetanus toxoid (TT) and varicella, and immunogenicity of post-chemotherapy DTaP-IPV-Hib and pneumococcal vaccination among previously vaccinated children treated for ALL.

Methods: This was a multi-center trial of children with ALL enrolled 4-12 months post-chemotherapy completion. Read More

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http://dx.doi.org/10.1093/cid/ciaa163DOI Listing
February 2020

Safety and effectiveness of acellular pertussis vaccination during pregnancy: a systematic review.

BMC Infect Dis 2020 Feb 13;20(1):136. Epub 2020 Feb 13.

Immunization Unit, Robert Koch Institute, Seestrasse 10, 13353, Berlin, Germany.

Background: Infants < 3 months of age are at highest risk for developing severe complications after pertussis. The majority of pregnant women has low concentrations of pertussis-specific antibodies and thus newborns are insufficiently protected by maternally transferred antibodies. Acellular pertussis vaccination during pregnancy was recently implemented in various countries. Read More

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http://dx.doi.org/10.1186/s12879-020-4824-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020352PMC
February 2020

Order of Live and Inactivated Vaccines and Risk of Non-vaccine-targeted Infections in US Children 11-23 Months of Age.

Pediatr Infect Dis J 2020 03;39(3):247-253

From the Kaiser Permanente Colorado, Institute for Health Research, Aurora, Colorado.

Background: Some findings from observational studies have suggested that recent receipt of live vaccines may be associated with decreased non-vaccine-targeted infection risk and mortality. Our objective was to estimate risk of non-vaccine-targeted infections based on most recent vaccine type (live vaccines only, inactivated vaccines only or both concurrently) received in US children 11-23 months of age.

Methods: We conducted a retrospective cohort study within the Vaccine Safety Datalink. Read More

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http://dx.doi.org/10.1097/INF.0000000000002550DOI Listing

Fever After Influenza, Diphtheria-Tetanus-Acellular Pertussis, and Pneumococcal Vaccinations.

Pediatrics 2020 03 6;145(3). Epub 2020 Feb 6.

Immunization Safety Office, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Administering inactivated influenza vaccine (IIV), 13-valent pneumococcal conjugate vaccine (PCV13), and diphtheria-tetanus-acellular pertussis (DTaP) vaccine together has been associated with increased risk for febrile seizure after vaccination. We assessed the effect of administering IIV at a separate visit from PCV13 and DTaP on postvaccination fever.

Methods: In 2017-2018, children aged 12 to 16 months were randomly assigned to receive study vaccines simultaneously or sequentially. Read More

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http://dx.doi.org/10.1542/peds.2019-1909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055925PMC

Update from the Advisory Committee on Immunization Practices.

J Pediatric Infect Dis Soc 2020 Feb;9(1):3-5

Department of Pediatrics, University of Alabama at Birmingham.

The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. There are usually 15 voting members; members' terms are for 4 years. ACIP members and Centers for Disease Control and Prevention staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and results from clinical trials. Read More

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http://dx.doi.org/10.1093/jpids/piaa008DOI Listing
February 2020

An Investigation of Japanese Neonatal and Maternal Antibody Status against Pertussis.

Jpn J Infect Dis 2020 May 31;73(3):231-234. Epub 2020 Jan 31.

Department of Pediatrics, Konan Kosei Hospital.

To clarify the pertussis immune status of the Japanese population, we investigated levels of serum pertussis toxin (PT)-specific immunoglobulin G (IgG) antibody in infants and mothers between April 2016 and March 2018. A total of 206 infants (n = 22, < 32 weeks of gestational age [wGA]; n = 70, 32-36 wGA; n = 114, ≥ 37 wGA) and 170 mothers were enrolled. The maternal seroprevalence and antibody geometric mean titer (GMT) were 52. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2019.386DOI Listing

Vaccination coverage of general practitioners: a cross-sectional study from Greece.

Public Health 2020 Apr 27;181:110-113. Epub 2020 Jan 27.

Clinic of Social and Family Medicine, School of Medicine, University of Crete, Heraklion, 71003, Greece. Electronic address:

Objectives: Vaccination coverage of general practitioners (GPs) is important for their own and for their colleagues' and patients' protection and has been associated with the coverage of the general population. Our study aims to evaluate the vaccination practices of GPs in Crete, Greece.

Study Design: Cross-sectional, questionnaire-based survey. Read More

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http://dx.doi.org/10.1016/j.puhe.2019.12.012DOI Listing

Determining Factors for Pertussis Vaccination Policy: A Study in Five EU Countries.

Vaccines (Basel) 2020 Jan 26;8(1). Epub 2020 Jan 26.

Institut Pasteur, Unit Biodiversity and Epidemiology of Bacterial Pathogens, 25 rue du Dr Roux, F-75724 Paris CEDEX 15, France.

Pertussis vaccination policy varies across Europe, not only in the type of vaccine-whole cell (wP) vs. acellular (aP1/2/3/5)-but also in the schedule and recommendation for parents. This study aims to investigate the determining factors for the type of vaccine, immunization schedule and maternal immunization recommendation. Read More

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http://dx.doi.org/10.3390/vaccines8010046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158661PMC
January 2020

Impact of maternal dTpa vaccination on the incidence of pertussis in young infants.

PLoS One 2020 28;15(1):e0228022. Epub 2020 Jan 28.

Centro Infant, Department of Pediatrics, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.

Introduction: Pertussis is an important public health problem worldwide, especially in infants. An increase in the incidence in many countries occurred after 2010, including Brazil. In 2013, dTpa vaccine was introduced in the Brazil national immunization schedule of pregnant women. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228022PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986709PMC

Vaccination Programs for Adults in Europe, 2019.

Vaccines (Basel) 2020 Jan 20;8(1). Epub 2020 Jan 20.

Department for Interventions in Health Care Facilities, National Organization of Public Health, 15123 Athens, Greece.

Background: While all European countries implement vaccination programs for children, there are gaps in terms of vaccination programs for adults.

Methods: We studied the 2019 vaccination policies for adults in 42 European countries.

Results: Vaccination programs for adults were in place in all countries. Read More

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http://dx.doi.org/10.3390/vaccines8010034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157239PMC
January 2020