2,537 results match your criteria Pediatrics Otitis Media


Clinical Profile and Outcome of Brain Abscess in Children from a Tertiary Care Hospital in Eastern Uttar Pradesh.

Ann Indian Acad Neurol 2020 May-Jun;23(3):303-307. Epub 2020 Jun 10.

Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Background And Aims: Brain abscess is a serious and dreadful disease presenting at tertiary centre. The objective of this study was to look into the clinical profile, predisposing conditions, microbiology and outcome of children suffering from brain abscess.

Methods: 30 children up to 18 years with clinical and imaging evidence of brain abscess were taken for study. Read More

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http://dx.doi.org/10.4103/aian.AIAN_425_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313559PMC

Early life bacterial airway colonization, local immune mediator response and risk of otitis media.

J Med Microbiol 2020 Jun 29. Epub 2020 Jun 29.

Department of Food Science, University of Copenhagen, Frederiksberg, Denmark.

Acute otitis media (AOM) is the most common bacterial infection in early childhood, but the underlying mechanisms making some children more susceptible are poorly understood. To examine the associations between bacterial airway colonization in early life and the risk of AOM and tympanostomy tube insertion (TTI), and whether such associations are modulated by an insufficient local immune mediator response to bacterial colonization. Bacterial cultures from hypopharyngeal samples were obtained at 1 week, 1 month and 3 months of age in the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC) cohort comprising 700 children. Read More

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http://dx.doi.org/10.1099/jmm.0.001227DOI Listing

Paediatrics in Theresienstadt ghetto.

Cent Eur J Public Health 2020 Jun;28(2):155-160

Faculty of Education, Comenius University, Bratislava, Slovak Republic.

The main objective of this study is to describe the most common childhood diseases occurring in the Theresienstadt ghetto during the Second World War as well as applied anti-epidemic measures. A partial objective is to describe medical and nursing care of sick child prisoners. The data was obtained by the method of synthesis of primary and secondary data with the highest importance after adequate external source criticism using selected monographs, memoirs, survivor diaries, Orders of the day by the Council of the Elders and Reports of the Jewish self-government of the Theresienstadt ghetto from 1941 to 1945, the Archives of the Jewish Museum in Prague, the Ghetto Museum, the Museum of the History of Polish Jews in Warsaw, Post Bellum online electronic collection of oral historical interviews, and witness accounts. Read More

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http://dx.doi.org/10.21101/cejph.a5557DOI Listing

Decreased expression of autophagy markers in culture-positive patients with chronic otitis media.

J Int Med Res 2020 Jun;48(6):300060520936174

Medical Science Research Institute, Kyung Hee University Medical Center, Seoul, Republic of Korea.

Objective: Abnormal autophagy plays a role in the pathogenesis of various diseases. This study aimed to evaluate associations between the clinical manifestations of chronic otitis media (COM) and expression of autophagy markers.

Methods: Associations between presence of bacteria, otorrhea, and conductive and sensorineural hearing loss and levels of autophagy-related mRNAs were investigated in 47 patients with COM. Read More

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http://dx.doi.org/10.1177/0300060520936174DOI Listing

Extrapulmonary Surfactant Therapy: Review of Available Data and Research/Development Issues.

J Clin Pharmacol 2020 Jun 23. Epub 2020 Jun 23.

Division of Pediatrics and Neonatal Critical Care, Medical Center, "A. Béclère," South Paris University Hospitals, Assistance Publique-Hopitaux de Paris (APHP), Paris, France.

Since the discovery of surfactant, a large amount of knowledge has been accumulated about its biology and pharmacology. Surfactant is the cornerstone of neonatal respiratory critical care, but its proteins and phospholipids are produced in various tissues and organs, with possible roles only partially similar to that played in the alveoli. As surfactant research is focused mainly on its respiratory applications, knowledge about the possible role of surfactant in extrapulmonary disorders has never been summarized. Read More

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http://dx.doi.org/10.1002/jcph.1675DOI Listing

Associations between IFI44L gene variants and rates of respiratory tract infections during early childhood.

J Infect Dis 2020 Jun 19. Epub 2020 Jun 19.

Department of Paediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland.

Background: Genetic heterogeneity in type I interferon related gene IFI44L may account for variable susceptibility to respiratory tract infections (RTIs) in children.

Methods: In two prospective, population-based birth cohorts, the STEPS Study and the FinnBrain Birth Cohort Study, IFI44L genotypes for rs273259 and rs1333969 were determined in relation to the development of RTIs until one and two years of age, respectively. At age 3 months, whole blood transcriptional profiles were analyzed and nasal samples were tested for respiratory viruses in a subset of children. Read More

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http://dx.doi.org/10.1093/infdis/jiaa341DOI Listing

Tympanostomy Tubes-A Visual Guide for the Young Otolaryngologist.

Authors:
Glenn Isaacson

Ear Nose Throat J 2020 Jun 18:145561320929885. Epub 2020 Jun 18.

Departments of Otolaryngology, Head & Neck Surgery and Pediatrics, Lewis Katz, School of Medicine at Temple University, Philadelphia, PA, USA.

Objectives: To illustrate some of the common dilemmas in tympanostomy tube care and describe time-tested ways to address them.

Methods: Computerized literature review.

Results: Issues including the correct diagnosis of recurrent acute otitis media, tympanostomy tube types and techniques for tube placement, management of tube clogging and otorrhea, and methods for tube removal and patching are illustrated. Read More

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http://dx.doi.org/10.1177/0145561320929885DOI Listing

Does Otitis Media Affect Later Language Ability? A Prospective Birth Cohort Study.

J Speech Lang Hear Res 2020 Jun 15:1-12. Epub 2020 Jun 15.

Telethon Kids Institute, The University of Western Australia, Perth.

Purpose The aim of the study was to examine whether otitis media (OM) in early childhood has an impact on language development in later childhood. Methods We analyzed data from 1,344 second-generation (Generation 2) participants in the Raine Study, a longitudinal pregnancy cohort established in Perth, Western Australia, between 1989 and 1991. OM was assessed clinically at 6 years of age. Read More

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http://dx.doi.org/10.1044/2020_JSLHR-19-00005DOI Listing

Allergy and Otitis Media in Clinical Practice.

Curr Allergy Asthma Rep 2020 Jun 6;20(8):33. Epub 2020 Jun 6.

Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milan, Italy.

Purpose Of Review: Otitis media (OM) is a disease with very high prevalence in infancy, substantial burden on healthcare resources, and relevant impact on the quality of life of families. The link between OM and allergy is controversial and still debated. However, a fundamental premise has to be placed before introducing this topic: there is the need to use clear and unambiguous terms. Read More

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http://dx.doi.org/10.1007/s11882-020-00930-8DOI Listing

Otorhinolaryngological manifestations in 61 patients with mucopolysaccharidosis.

Int J Pediatr Otorhinolaryngol 2020 May 27;135:110137. Epub 2020 May 27.

Department of Pediatrics and Adolescent Medicine, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Pediatrics, Thomayer's Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address:

Objectives: The mucopolysaccharidoses (MPS) are inherited lysosomal storage disorders with multisystemic and highly variable clinical manifestation. ENT symptoms are common and early signs of MPS. The most common ENT diagnoses are chronic/recurrent rhinosinusitis, acute otitis media, otitis media with effusion, hearing loss and airway obstruction. Read More

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http://dx.doi.org/10.1016/j.ijporl.2020.110137DOI Listing

Acute mastoiditis in infants younger than 6 months: is an alternative treatment protocol needed?

Eur Arch Otorhinolaryngol 2020 Jun 4. Epub 2020 Jun 4.

Department of Otorhinolaryngology and Head and Neck Surgery, Schneider Children's Medical Center of Israel and Rabin Medical Center, Beilinson Campus, 49202, Petah Tikva, Israel.

Objectives: Several studies have reported that younger children suffer from increased incidence and more severe episodes of acute mastoiditis (AM) than older children, whereas other researchers have found the opposite. The aim of our study was to describe the occurrence, clinical, and microbiological aspects of AM in children 6 months or younger, and compare them with the results in an older reference age band.

Methods: The medical files of children hospitalized with a diagnosis of AM during 2001-2016 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s00405-020-06088-3DOI Listing

A multi-centre, pragmatic, three-arm, individually randomised, non-inferiority, open trial to compare immediate orally administered, immediate topically administered or delayed orally administered antibiotics for acute otitis media with discharge in children: The Runny Ear Study (REST): study protocol.

Trials 2020 Jun 3;21(1):463. Epub 2020 Jun 3.

Bristol Randomised Trial Collaboration (BRTC), part of the Bristol Trial Centre, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS82PS, UK.

Background: Acute otitis media (AOM) is a common painful infection in children, with around 2.8 million cases presenting to primary care in England and Wales annually. Nearly all children who present to their general practitioner (GP) with AOM or AOM with discharge (AOMd) are treated with orally administered antibiotics. Read More

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http://dx.doi.org/10.1186/s13063-020-04419-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268414PMC

Clinical features of 22q11.2 deletion syndrome related to hearing and communication.

Acta Otolaryngol 2020 Jun 4:1-5. Epub 2020 Jun 4.

Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.

Individuals with 22q11.2 deletion syndrome (22q11.2DS) exhibit various phenotypes. Read More

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http://dx.doi.org/10.1080/00016489.2020.1769862DOI Listing

Divergent serotype distribution between children with otitis media and those without in the pneumococcal conjugate vaccine era.

J Microbiol Immunol Infect 2020 May 19. Epub 2020 May 19.

Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Electronic address:

We investigated pneumococcal carriage between children ≦5 years old with otitis media (OM) and those without. Non-PCV13 serotypes were common in both groups; 19A remained the second most common serotype among children with OM despite high PCV13 coverage. This is important when considering a schedule with reduced vaccine doses or reduced valency, and the modification of pneumococcal immunization schedule should be followed up closely to monitor the result of protection against pneumococcal infections. Read More

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http://dx.doi.org/10.1016/j.jmii.2020.05.003DOI Listing
May 2020
2.349 Impact Factor

Nontypeable Haemophilus influenzae Responds to Virus-Infected Cells with a Significant Increase in Type IV Pilus Expression.

mSphere 2020 May 27;5(3). Epub 2020 May 27.

Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA

Nontypeable (NTHI) colonizes the human nasopharynx, but when the host immune response is dysregulated by upper respiratory tract (URT) virus infection, NTHI can gain access to more distal airway sites and cause disease. The NTHI type IV pilus (T4P) facilitates adherence, benign colonization, and infection, and its majority subunit PilA is in clinical trials as a vaccinogen. To further validate the strategy of immunization with PilA against multiple NTHI-induced diseases, it is important to demonstrate T4P expression under microenvironmental conditions that predispose to NTHI infection of the airway. Read More

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http://dx.doi.org/10.1128/mSphere.00384-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253600PMC

10-Valent pneumococcal non-typeable protein D conjugate vaccine (PHiD-CV10) versus 13-valent pneumococcal conjugate vaccine (PCV13) as a booster dose to broaden and strengthen protection from otitis media (PREVIX_BOOST) in Australian Aboriginal children: study protocol for a randomised controlled trial.

BMJ Open 2020 May 24;10(5):e033511. Epub 2020 May 24.

Child Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia

Introduction: and non-typeable (NTHi) are major otitis media pathogens that densely co-colonise the nasopharynx and infect the middle ear of Australian Aboriginal infants from very early in life. Our co-primary hypotheses are that at 18 months of age infants receiving 10-valent pneumococcal protein D conjugate vaccine (PHiD-CV10) compared with those receiving 13-valent pneumococcal conjugate vaccine (PCV13) as a booster at 12 months of age will have higher antibody levels to protein D and that infants receiving PCV13 will have higher antibody levels to PCV13-only serotypes 3, 6A and 19A.

Methods And Analyses: Our randomised controlled trial will enrol 270 Aboriginal children at 12 months of age to a booster dose of either PHiD-CV10 or PCV13. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252982PMC

Analysis of Inflammatory Signaling in Human Middle Ear Cell Culture Models of Pediatric Otitis Media.

Laryngoscope 2020 May 20. Epub 2020 May 20.

Department of Otolaryngology, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A.

Objectives/hypothesis: Cell culture models are valuable tools for investigation of the molecular pathogenesis of diseases including otitis media (OM). Previous study indicates that age-, sex-, and race-associated differences in molecular signaling may impact disease pathophysiology. Currently, a singular immortalized middle ear epithelial (MEE) cell line exists, HMEEC-1, derived from an adult without known middle ear disease. Read More

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http://dx.doi.org/10.1002/lary.28687DOI Listing

A double-blind, randomized, multicenter, controlled study to evaluate the immunogenicity, safety, and tolerability of varicella vaccine (VARIVAX™) passage extension 34 (PE34) process administered concomitantly with measles, mumps, and rubella vaccine (M-M-R™ II).

Hum Vaccin Immunother 2020 May 19:1-7. Epub 2020 May 19.

Merck & Co., Inc., Kenilworth, NJ, USA.

The varicella vaccine passage extension (VAR-PE) process was undertaken to extend the availability of varicella zoster virus (VZV)-containing vaccines. This study (V210-A03; NCT03239873) assessed the immunogenicity, safety, and tolerability of VAR-PE process in comparison with varicella vaccine commercial product 2016 (VAR) randomized 1:1 in 600 healthy children 12 to 23 months of age administered concomitantly with measles-mumps-rubella (MMR) vaccine. The VZV seroconversion rate at 6 weeks Postdose 1 in the PP population was 100% for both groups. Read More

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http://dx.doi.org/10.1080/21645515.2020.1743122DOI Listing

No evidence from a systematic review for the use of probiotics to prevent otitis media.

Acta Paediatr 2020 May 18. Epub 2020 May 18.

Department of Paediatrics, University of Otago Christchurch Campus, Christchurch, New Zealand.

Aim: This systematic review evaluates the current evidence for the use of probiotics in the prevention of acute otitis media (AOM) in children.

Methods: This study is registered with PROSPERO prior to commencement. PubMed, MEDLINE, EMBASE and Cochrane database were searched using relating keywords. Read More

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http://dx.doi.org/10.1111/apa.15368DOI Listing

First report on multidrug-resistant non-encapsulated Streptococcus pneumoniae isolated from a patient with pneumonia.

J Infect Chemother 2020 Jul 12;26(7):749-751. Epub 2020 May 12.

Department of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba, Japan.

The non-encapsulated Streptococcus pneumoniae (NESp) has emerged and increased in the clinical setting. The majority of NESp strains have been isolated from the nasopharynxes of healthy carriers and from respiratory specimens of patients with otitis media. NESp strains were shown to be more effective than encapsulated counterparts at forming biofilms. Read More

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http://dx.doi.org/10.1016/j.jiac.2020.02.009DOI Listing

Long-term effect of middle ear disease on temporal processing and P300 in two different populations of children.

PLoS One 2020 8;15(5):e0232839. Epub 2020 May 8.

Department of Pediatrics, State University of Campinas, Campinas, São Paulo, Brazil.

Background/objective: The effects of otitis media on the function of the central auditory nervous system in different populations is unknown. Understanding how the history of otitis media affects children from different nations will guide health professionals worldwide on the importance of adequate auditory stimulus in childhood. For this reason, the aim of the present study was to investigate the long-term auditory effects of middle ear disease on temporal processing and P300 in two different populations of children: Australian and Brazilian. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232839PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209102PMC

Primary Presentation of Pediatric Hematopoietic Malignancy in the Temporal Bone: Case Report and Review of the Literature.

Ear Nose Throat J 2020 May 8:145561320924146. Epub 2020 May 8.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of New Mexico Hospital, NM, USA.

Malignancy of hematopoietic origin comprises a large portion of all pediatric malignancies; however, it is uncommon for patients with this condition to present only with symptoms related to temporal bone involvement. Here, we report a case of Burkitt Lymphoma of the temporal bone in an 8-year-old patient who initially presented with symptoms of acute otitis media. Additionally, we review the current literature on pediatric hematopoietic malignancy with primary temporal bone involvement and discuss the clinical presentation, management, and outcomes of these rare cases. Read More

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http://dx.doi.org/10.1177/0145561320924146DOI Listing
May 2020
0.881 Impact Factor

A longitudinal hospital-based epidemiology study to assess acute otitis media incidence and nasopharyngeal carriage in Korean children up to 24 months.

Hum Vaccin Immunother 2020 Apr 24:1-8. Epub 2020 Apr 24.

Department of Pediatrics, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.

This study was conducted to assess the nasopharyngeal (NP) carriage and acute otitis media (AOM) occurrence in Korean children who received pneumococcal conjugate vaccines (PCVs). The longitudinal study was conducted through four consecutive visits. At each visit, NP aspirates were obtained and subjects were asked to visit if AOM occurred. Read More

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http://dx.doi.org/10.1080/21645515.2020.1748978DOI Listing

Respiratory Complications in Children Hospitalized with Respiratory Syncytial Virus Infection.

Adv Exp Med Biol 2020 ;1279:113-120

Department of Pediatrics, Medical Center of Postgraduate Medical Education, Warsaw, Poland.

The goal of this study was to define the prevalence of respiratory complications, other than bronchiolitis, such as pneumonia, acute otitis media, and conjunctivitis in children treated in a hospital due to respiratory syncytial virus (RSV) infection, with reference to the plausible risk factors. The study included 111 children, aged up to 22 months (median 3 months). Complications were observed in 68 (61%) children, with 32 (29%) children presenting more than one. Read More

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http://dx.doi.org/10.1007/5584_2020_530DOI Listing
January 2020

Immunization with a Biofilm-Disrupting Nontypeable Vaccine Antigen Did Not Alter the Gut Microbiome in Chinchillas, Unlike Oral Delivery of a Broad-Spectrum Antibiotic Commonly Used for Otitis Media.

mSphere 2020 04 15;5(2). Epub 2020 Apr 15.

Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA

The use of broad-spectrum antibiotics to treat diseases, such as the highly prevalent pediatric disease otitis media (OM), contributes significantly to the worldwide emergence of multiple-antibiotic-resistant microbes, and gut dysbiosis with diarrhea is a common adverse sequela. Moreover, for many diseases, like OM, biofilms contribute significantly to chronicity and recurrence, yet biofilm-resident bacteria are characteristically highly resistant to antibiotics. The most cost-effective way to both prevent and resolve diseases like OM, as well as begin to address the problem of growing antibiotic resistance, would be via the development of novel approaches to eradicate bacterial biofilms. Read More

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http://dx.doi.org/10.1128/mSphere.00296-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160684PMC

Middle ear disease in CF? It's not just about the sinuses anymore!

Int J Pediatr Otorhinolaryngol 2020 Jul 1;134:110032. Epub 2020 Apr 1.

Division of Pediatric Otolaryngology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

Introduction: Historically cystic fibrosis (CF), in contrast to primary ciliary dyskinesia (PCD), has been considered protective of the middle ear from otitis media and rarely were such patients "severely affected" to require tympanostomy tube placement (BMT). Previously the Pittsburgh Otitis Media Research group reported a 10% prevalence of otitis media in the pediatric CF population which is significantly lower than age matched non-CF children. We studied the prevalence of OM in pediatric CF patients to assess if the otologic phenotype has changed in parallel with changes in the diagnosis itself. Read More

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http://dx.doi.org/10.1016/j.ijporl.2020.110032DOI Listing

A rare cause of acute abdominal pain in a patient with Primary ciliary dyskinesia with situs inversus totalis.

Turk J Pediatr 2020 ;62(1):156-159

Departments of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Primary ciliary dyskinesia (PCD) is a rare, genetic disease characterized by ciliary dysfunction. Patients may present with respiratory distress during neonatal period; chronic sinopulmonary disease, bronchiectasis, recurrent otitis media, sinusitis and infertility in later periods. About 50% of PCD patients have situs inversus totalis and 6-12% have situs ambiguous known as heterotaxy syndromes. Read More

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http://dx.doi.org/10.24953/turkjped.2020.01.024DOI Listing
January 2020

Birth by Caesarean section and otitis media in childhood: a retrospective cohort study.

Sci Rep 2020 Mar 23;10(1):5219. Epub 2020 Mar 23.

Perinatal Epidemiology Research Unit, Depts of Obstetrics & Gynaecology and Pediatrics, Dalhousie University, Halifax, NS, Canada.

The objective of the present study was to examine the association between birth by Caesarean section (CS) and otitis media (OM) in childhood. We assembled a retrospective cohort of children born between 2003 and 2007 in Nova Scotia and followed them through to 2014. The cohort was derived through a linkage of the Nova Scotia Atlee Perinatal Database with provincial administrative health data. Read More

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http://dx.doi.org/10.1038/s41598-020-62229-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090017PMC

Influenza a H1N1 associated acute glomerulonephritis in an adolescent.

IDCases 2020 15;19:e00659. Epub 2019 Oct 15.

Department of Pediatrics, Thriasio General Hospital, Athens, Greece.

Influenza virus primarily affects the respiratory system. It rarely causes extrapulmonary complications, with otitis media and febrile seizures being the most common in children. Acute glomerulonephritis as a complication of H1N1 influenza virus infection has been described only sporadically. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093738PMC
October 2019

Prevalence of Hearing Loss among School-Age Children in the North of Iran.

Iran J Otorhinolaryngol 2020 Mar;32(109):85-92

Otorhinolaryngology Research Center, Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Introduction: The present study aimed to investigate the audiological profiles of elementary school-age children in Rasht, Iran, and estimate the prevalence of hearing impairments in this population

Materials And Methods: In this cross-sectional descriptive-analytical study, the hearing threshold was screened using pure tone audiometry (PTA). Hearing impairment was defined as equal to or higher than 20 dB HL. Results of the hearing thresholds were separately reported in the left or right ears and better or worse ears. Read More

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http://dx.doi.org/10.22038/ijorl.2019.36090.2191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085924PMC

[Acute mastoiditis with intracranial complication in a pediatric patient].

Arch Argent Pediatr 2020 04;118(2):e166-e169

Unidad de Infectología Pediátrica, Hospital Infantil Miguel Servet, Zaragoza, España.

Acute mastoiditis is an infection that affects the mastoid air-cell system, usually due to the progression of an acute otitis media. The bacteria most frequently isolated in acute mastoiditis are Streptococcus pneumoniae, Streptococcus pyogenes and Staphylococcus aureus. The mastoid infection can extend affecting contiguous structures and producing intra or extracranial complications. Read More

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http://dx.doi.org/10.5546/aap.2020.e166DOI Listing

Unsolved problems and new medical approaches to otitis media.

Expert Opin Biol Ther 2020 Jul 20;20(7):741-749. Epub 2020 Apr 20.

Pediatric Clinic, Pietro Barilla Children's Hospital, Department of Medicine and Surgery, University of Parma , Parma, Italy.

Introduction: Otitis media (OM) is a spectrum of infectious and inflammatory diseases that involve the middle ear. It includes acute otitis media (AOM), otitis media with effusion (OME) and chronic suppurative otitis media (CSOM).

Areas Covered: This manuscript discusses some of the emerging and unsolved problems regarding OM, and some of the newly developed prophylactic and therapeutic medical measures. Read More

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http://dx.doi.org/10.1080/14712598.2020.1740677DOI Listing

Comparative Usability Analysis and Parental Preferences of Three Web-Based Knowledge Translation Tools: Multimethod Study.

J Med Internet Res 2020 Mar 13;22(3):e14562. Epub 2020 Mar 13.

Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.

Background: Connecting parents to research evidence is known to improve health decision making. However, guidance on how to develop effective knowledge translation (KT) tools that synthesize child-health evidence into a form understandable by parents is lacking.

Objective: The aim of this study was to conduct a comparative usability analysis of three Web-based KT tools to identify differences in tool effectiveness, identify which format parents prefer, and better understand what factors affect usability for parents. Read More

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http://dx.doi.org/10.2196/14562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101501PMC

Efficacy and Effectiveness of the PCV-10 and PCV-13 Vaccines Against Invasive Pneumococcal Disease.

Pediatrics 2020 04 10;145(4). Epub 2020 Mar 10.

Department of Epidemiology, Biostatistics, and Occupational Health and

Context: Pneumococcal conjugate vaccines (PCVs) (pneumococcal 13-valent conjugate vaccine [PCV-13] and pneumococcal 10-valent conjugate vaccine [PCV-10]) are available for prevention of pneumococcal infections in children.

Objective: To determine the vaccine effectiveness (VE) of PCV-13 and PCV-10 in preventing invasive pneumococcal disease (IPD) and acute otitis media (AOM) in children <5 years.

Data Sources: Systematic searches of Medline, Embase, Cumulative Index to Nursing and Allied Health Literature, Web of Science, and Cochrane. Read More

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http://dx.doi.org/10.1542/peds.2019-0377DOI Listing

Gradenigo's Syndrome with Carotid Septic Stenosis.

Case Rep Otolaryngol 2020 19;2020:9439184. Epub 2020 Feb 19.

Department of Otorhinolaryngology-Head and Neck Surgery, Hospital de Braga, Braga, Portugal.

Gradenigo's syndrome was firstly described in 1907 by Giusseppe Gradenigo and is defined as the clinical triad of suppurative otitis media, ipsilateral abducens nerve palsy, and pain in the distribution of the first and the second branches of the trigeminal nerve. Since the advent of antibiotics, the incidence of this potentially life-threatening complication has diminished, but occasional cases still occur. We herein report a pediatric case of otitis media associated with Gradenigo's syndrome complicated by ipsilateral septic cavernous sinus thrombosis and infectious arteritis of the internal carotid artery. Read More

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http://dx.doi.org/10.1155/2020/9439184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053453PMC
February 2020

Early Childhood Antibiotic Treatment for Otitis Media and Other Respiratory Tract Infections Is Associated With Risk of Type 1 Diabetes: A Nationwide Register-Based Study With Sibling Analysis.

Diabetes Care 2020 May 4;43(5):991-999. Epub 2020 Mar 4.

Molecular Epidemiology, Department of Medical Sciences, and Science for Life Laboratory, Uppsala University, Uppsala, Sweden

Objective: The effect of early-life antibiotic treatment on the risk of type 1 diabetes is debated. This study assessed this question, applying a register-based design in children up to age 10 years including a large sibling-control analysis.

Research Design And Methods: All singleton children ( = 797,318) born in Sweden between 1 July 2005 and 30 September 2013 were included and monitored to 31 December 2014. Read More

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http://dx.doi.org/10.2337/dc19-1162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171951PMC

Effect of Class Switch Recombination Defect on the Phenotype of Ataxia-Telangiectasia Patients.

Immunol Invest 2020 Mar 2:1-15. Epub 2020 Mar 2.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, University of Medical Science, Tehran, Iran.

: Ataxia-telangiectasia (A-T) is an autosomal recessive neurodegenerative disorder with multisystem involvement caused by homozygous or compound heterozygous mutations in the gene which encodes a serine/threonine protein kinase. The aims of this study were to investigate class switch recombination (CSR) and to review the clinical and immunologic phenotypes of 3 groups of A-T patients, including A-T patients with CSR defects (CSR-D), A-T patients with selective immunoglobulin A deficiency (IgA-D) and A-T patients with normal Ig level.: In this study, 41 patients with confirmed diagnosis of A-T (16 A-T patients with HIgM, 15 A-T patients with IgA-D, and 10 A-T patients with normal Ig levels) from Iranian immunodeficiency registry center were enrolled. Read More

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http://dx.doi.org/10.1080/08820139.2020.1723104DOI Listing
March 2020
1.903 Impact Factor

Antibiotic Prescribing Patterns for Acute Otitis Media for Children 2 Years and Older.

J Pediatr 2020 May 25;220:109-115.e1. Epub 2020 Feb 25.

Division of Infectious Diseases and Department of Medicine, Denver Health Medical Center, Denver, CO; Department of Internal Medicine-Infectious Diseases, University of Colorado School of Medicine, Aurora, CO.

Objective: To determine the frequency that non-first-line antibiotics, safety-net antibiotic prescriptions (SNAPS), and longer than recommended durations of antibiotics were prescribed for children ≥2 years of age with acute otitis media and examine patient and system level factors that contributed to these outcomes.

Study Design: Children age ≥2 years with acute otitis media seen at Denver Health Medical Center outpatient locations from January to December 2018 were included. The percentages of patients who received first-line antibiotics, SNAPs, and recommended durations of antibiotics were determined. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.01.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249267PMC

How well do we know Gradenigo? A comprehensive literature review and proposal for novel diagnostic categories of Gradenigo's syndrome.

Int J Pediatr Otorhinolaryngol 2020 Feb 8;132:109942. Epub 2020 Feb 8.

Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Divisions of Hospital Medicine, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, USA; Divisions of Infectious Disease, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, USA. Electronic address:

Gradenigo's Syndrome is a rare complication of otitis media and/or mastoiditis resulting in inflammation of the petrous apex of the temporal bone. Here, we highlight an interesting case from our institution, summarize available pediatric cases from the past fifty years to provide an updated diagnostic categorization for this rare condition with confusing nomenclature, and suggest guidance for diagnosis and management. Read More

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http://dx.doi.org/10.1016/j.ijporl.2020.109942DOI Listing
February 2020

Health benefits of GG and subspecies BB-12 in children.

Postgrad Med 2020 Feb 26:1-11. Epub 2020 Feb 26.

Referral Center for Pediatric Gastroenterology and Nutrition, Children's Hospital Zagreb, Zagreb, Croatia.

While the literature indicates that probiotics are effective for the treatment or prevention of several conditions, data in children specifically focusing on individual probiotic strains are still limited. To conduct a narrative review that summarizes data on the efficacy and safety of two common probiotic strains - GG (LGG) and subspecies BB-12 (BB-12) - when administered to children. Our search of the PubMed database identified 13 meta-analyses, three systematic reviews, and 15 randomized, controlled trials that assessed BB-12 and LGG, either alone or in combination, when administered to infants to improve growth or to children of any age to prevent or treat acute gastroenteritis (AGE), antibiotic- or healthcare-associated diarrhea (AAD and HAD, respectively), respiratory infections, otitis media, and functional gastrointestinal (GI) disorders including irritable bowel syndrome (IBS). Read More

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http://dx.doi.org/10.1080/00325481.2020.1731214DOI Listing
February 2020

Clinical Practice Guidelines for Achondroplasia.

Clin Pediatr Endocrinol 2020 9;29(1):25-42. Epub 2020 Jan 9.

Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.

Achondroplasia (ACH) is a skeletal dysplasia that presents with limb shortening, short stature, and characteristic facial configuration. ACH is caused by mutations of the gene, leading to constantly activated FGFR3 and activation of its downstream intracellular signaling pathway. This results in the suppression of chondrocyte differentiation and proliferation, which in turn impairs endochondral ossification and causes short-limb short stature. Read More

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http://dx.doi.org/10.1297/cpe.29.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958518PMC
January 2020

A Case Report of a Japanese Boy with Morquio A Syndrome: Effects of Enzyme Replacement Therapy Initiated at the Age of 24 Months.

Int J Mol Sci 2020 Feb 2;21(3). Epub 2020 Feb 2.

Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima 7348511, Japan.

Background: Morquio A syndrome, mucopolysaccharidosis type IVA (MPS IVA), is a lysosomal storage disorder caused by the deficient activity of N-acetylgalactosamine-6-sulfatase (GalNac6S), due to alterations in the gene. This disorder results in marked abnormalities in bones and connective tissues, and affects multiple organs. Here, we describe the clinical course of a Japanese boy with MPS IVA who began enzyme replacement therapy (ERT) at the age of 24 months. Read More

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http://dx.doi.org/10.3390/ijms21030989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037301PMC
February 2020

Parental Judgement of Hearing Loss in Infants With Cleft Palate.

Authors:
Lucy McAndrew

Cleft Palate Craniofac J 2020 Jul 4;57(7):886-894. Epub 2020 Feb 4.

Spires Cleft Centre Oxford, Level 2, Children's Hospital, John Radcliffe Hospital, Headley Way, Oxford, United Kingdom.

Objective: To investigate whether reported parental concern is supported by hearing assessment findings in children with cleft palate. To describe this population by examining the relationship between cleft type, middle ear status, and hearing loss.

Design: Retrospective consecutive case note review. Read More

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http://dx.doi.org/10.1177/1055665619899743DOI Listing

Comprehensive assessment of respiratory complications in patients with common variable immunodeficiency.

Ann Allergy Asthma Immunol 2020 05 30;124(5):505-511.e3. Epub 2020 Jan 30.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran. Electronic address:

Background: Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by recurrent upper and lower respiratory tract infections and some noninfectious clinical complications.

Objective: To provide a detailed evaluation of respiratory presentations and complications in a cohort of Iranian patients with CVID.

Methods: A retrospective cohort study was conducted on 245 CVID patients who were recorded in the Iranian primary immunodeficiency disorders registry network. Read More

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http://dx.doi.org/10.1016/j.anai.2020.01.019DOI Listing
May 2020
2.599 Impact Factor

Complication of otitis media leads to opisthotonos in a toddler.

Am J Emerg Med 2020 Jun 17;38(6):1296.e5-1296.e7. Epub 2020 Jan 17.

Lehigh Valley Health Network, Department of Emergency and Hospital Medicine/USF, Morsani College of Medicine, Cedar Crest Boulevard & I-78, Allentown, PA 18103, USA.

Opisthotonos, extreme involuntary neck and back extension, is rarely seen in modern emergency departments. Vaccines have prevented the most common causes of this clinical presentation. Alternatively, otitis media is one of the most common pediatric infections and is characteristically non-invasive and harmless. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.01.028DOI Listing

Acute Otitis Media.

JAMA Pediatr 2020 Jan 27. Epub 2020 Jan 27.

Department of Pediatrics, University of Wisconsin-Madison, Madison.

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http://dx.doi.org/10.1001/jamapediatrics.2019.5664DOI Listing
January 2020

Common Variable Immunodeficiency: A Standardized Patient Case for Second-Year Medical Students.

MedEdPORTAL 2019 10 18;15:10837. Epub 2019 Oct 18.

Assistant Professor, Department of Science Education, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell.

Introduction: Common variable immunodeficiency (CVID) is the most common symptomatic antibody deficiency, with a prevalence of 0.6-6.9 depending on the population studied. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974347PMC
October 2019

Quality of Patient Education Sections on Otitis Media Across Different Website Platforms.

Ann Otol Rhinol Laryngol 2020 Jun 24;129(6):591-598. Epub 2020 Jan 24.

Department of Surgery, Section of Otolaryngology, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA.

Objective: To determine the quality, content, and readability of patient education materials pertaining to otitis media across several popular online platforms focused on otolaryngology and pediatric primary care education.

Methods: Online patient materials related to otitis media and directed toward parents were collected from the American Association for Family Practice (AAFP), ENT-Health section of the American Academy of Otolaryngology-Head and Neck Surgery, Healthychildren.org from the American Academy of Pediatrics, KidsHealth from Nemours, WebMD, and Wikipedia. Read More

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http://dx.doi.org/10.1177/0003489420902183DOI Listing

Nasal Delivery of a Commensal Species Inhibits Nontypeable Haemophilus influenzae Colonization and Delays Onset of Otitis Media in Mice.

Infect Immun 2020 03 23;88(4). Epub 2020 Mar 23.

Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Australia

Nasopharyngeal colonization with nontypeable (NTHi) is a prerequisite for developing NTHi-associated infections, including otitis media. Therapies that block NTHi colonization may prevent disease development. We previously demonstrated that , a closely related human commensal, can inhibit NTHi colonization and infection of human respiratory epithelium We have now assessed whether (a rodent commensal from the same family) can prevent NTHi colonization and disease using a murine NTHi otitis media model. Read More

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http://dx.doi.org/10.1128/IAI.00685-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093147PMC