909 results match your criteria Pediatrics Mumps


Paediatrics in Theresienstadt ghetto.

Cent Eur J Public Health 2020 Jun;28(2):155-160

Faculty of Education, Comenius University, Bratislava, Slovak Republic.

The main objective of this study is to describe the most common childhood diseases occurring in the Theresienstadt ghetto during the Second World War as well as applied anti-epidemic measures. A partial objective is to describe medical and nursing care of sick child prisoners. The data was obtained by the method of synthesis of primary and secondary data with the highest importance after adequate external source criticism using selected monographs, memoirs, survivor diaries, Orders of the day by the Council of the Elders and Reports of the Jewish self-government of the Theresienstadt ghetto from 1941 to 1945, the Archives of the Jewish Museum in Prague, the Ghetto Museum, the Museum of the History of Polish Jews in Warsaw, Post Bellum online electronic collection of oral historical interviews, and witness accounts. Read More

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http://dx.doi.org/10.21101/cejph.a5557DOI Listing

Routine vaccination during covid-19 pandemic response.

BMJ 2020 06 16;369:m2392. Epub 2020 Jun 16.

UCL Great Ormond Street Institute of Child Health, London, UK.

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http://dx.doi.org/10.1136/bmj.m2392DOI Listing

Investigating the etiologic agents of aseptic meningitis outbreak in Iranian children.

J Family Med Prim Care 2020 Mar 26;9(3):1573-1577. Epub 2020 Mar 26.

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Nemazi Hospital, Shiraz, Iran.

Introduction: This study aimed to determine the viral agent (s) and their genome burden associated with an aseptic meningitis outbreak that occurred in Yasuj, Iran.

Materials And Methods: During April to August 2015, 104 CSF samples from 104 patients under 14 years old admitted to the hospital of Yasuj, Iran, with aseptic meningitis associated clinical signs were collected. 200 μl CSF specimens was prepared for DNA and RNA viral genome extraction each and then subjected to diagnostic Taq-man real time PCR assays for the present of Enteroviruses, HSV, VZV, mumps, measles and rubella in the samples. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_1003_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266184PMC

Bilateral Optic Neuritis: A Rare Complication of Mumps.

Cureus 2020 Apr 21;12(4):e7768. Epub 2020 Apr 21.

Pediatrics, United Medical and Dental College, Creek General Hospital, Karachi, PAK.

Mumps is a contagious viral illness that classically presents with fever, parotid gland swelling, headache, and vomiting in unimmunized children. The complications of mumps most commonly include orchitis, pancreatitis, encephalitis, and meningitis. Optic neuritis, which refers to the inflammation of the optic nerve, in rare cases, can present after mumps meningoencephalitis and causes pain in the eye, and a decrease in visual acuity. Read More

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http://dx.doi.org/10.7759/cureus.7768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243626PMC

A double-blind, randomized, multicenter, controlled study to evaluate the immunogenicity, safety, and tolerability of varicella vaccine (VARIVAX™) passage extension 34 (PE34) process administered concomitantly with measles, mumps, and rubella vaccine (M-M-R™ II).

Hum Vaccin Immunother 2020 May 19:1-7. Epub 2020 May 19.

Merck & Co., Inc., Kenilworth, NJ, USA.

The varicella vaccine passage extension (VAR-PE) process was undertaken to extend the availability of varicella zoster virus (VZV)-containing vaccines. This study (V210-A03; NCT03239873) assessed the immunogenicity, safety, and tolerability of VAR-PE process in comparison with varicella vaccine commercial product 2016 (VAR) randomized 1:1 in 600 healthy children 12 to 23 months of age administered concomitantly with measles-mumps-rubella (MMR) vaccine. The VZV seroconversion rate at 6 weeks Postdose 1 in the PP population was 100% for both groups. Read More

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http://dx.doi.org/10.1080/21645515.2020.1743122DOI Listing

Review of pediatric encephalitis and encephalopathy cases following immunization reported to the Canadian Immunization Monitoring Program Active (IMPACT) from 1992 to 2012.

Vaccine 2020 Jun 12;38(28):4457-4463. Epub 2020 May 12.

Department of Pediatrics, Dalhousie University and Canadian Center for Vaccinology, IWK Health Centre, Halifax, NS, Canada. Electronic address:

Background: Neurological adverse events following immunization (AEFI) remain poorly characterized. Our objective was to describe pediatric acute and chronic encephalopathy and encephalitis cases following immunization reported via active sentinel surveillance from 1992 to 2012.

Methods: This case series provides a descriptive analysis of encephalopathy/encephalitis admissions reported to the Canadian Immunization Monitoring Program ACTive (IMPACT). Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.04.035DOI Listing

Anaphylaxis to MMR Vaccine Mediated by IgE Sensitivity to Gelatin.

Mil Med 2020 May 12. Epub 2020 May 12.

Allergy and Immunology, Wilford Hall Medical Center, 59th Medical Group, 2200 Bergquist Drive Lackland Air Force Base, San Antonio, TX 78236.

The measles-mumps-rubella (MMR) vaccine is generally well tolerated, and reports of anaphylaxis to the vaccine are rare. IgE-mediated reactions to vaccines are often caused by additives or residual vaccine components. An inability to obtain proper immunizations can be a disqualifying component to military service. Read More

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http://dx.doi.org/10.1093/milmed/usaa058DOI Listing

Antibodies to measles, mumps, and rubella virus in Thai children after two-dose vaccination at 9 months and 2.5 years: A longitudinal study.

Vaccine 2020 May 21;38(24):4016-4023. Epub 2020 Apr 21.

Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Academy of Science, Royal Society of Thailand, Bangkok, Thailand. Electronic address:

Introduction: Thailand changed the schedule of childhood measles-mumps-rubella (MMR) vaccination in 2014, moving the second dose from the age of 6 years to 2.5 years. There are currently no data on antibody responses to the MMR vaccine since this recommendation. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.04.013DOI Listing

Seroprevalences of antibodies against pertussis, diphtheria, tetanus, measles, mumps and rubella: A cross-sectional study in children following vaccination procedure in Guangzhou, China.

Vaccine 2020 May 19;38(23):3960-3967. Epub 2020 Apr 19.

Department of Pediatrics, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China. Electronic address:

This study investigated the concentrations and seroprevalence of immunoglobulin G (IgG) antibodies against pertussis, diphtheria, tetanus, measles, mumps and rubella among children in Guangzhou, China. We conducted a cross-sectional study focusing on the post-vaccination immune statuses of children on scheduled immunisation. Human IgG antibody against six diseases were measured using commercial enzyme-linked immunosorbent assay kits. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.03.056DOI Listing

Infectious diseases in children and adolescents in China: analysis of national surveillance data from 2008 to 2017.

BMJ 2020 04 2;369:m1043. Epub 2020 Apr 2.

Murdoch Children's Research Institute, Parkville, Victoria, Australia.

Objectives: To outline which infectious diseases in the pre-covid-19 era persist in children and adolescents in China and to describe recent trends and variations by age, sex, season, and province.

Design: National surveillance studies, 2008-17.

Setting: 31 provinces in mainland China. Read More

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http://dx.doi.org/10.1136/bmj.m1043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114954PMC

[Coverage rate and adverse reactions of National Immunization Program vaccines in children with spinal muscular atrophy: a cross-sectional retrospective cohort study].

Zhonghua Er Ke Za Zhi 2020 Apr;58(4):308-313

Department of Medical Genetics, Capital Institute of Pediatrics, Beijing 100020, China.

To investigate the coverage rate and the adverse reactions of National Immunization Program vaccines in children with spinal muscular atrophy (SMA). A cross-sectional retrospective cohort study was carried out from July 2016 to June 2019, 192 children (116 boys and 76 girls) with SMA registered by Capital Institute of Pediatrics and 191 healthy children (115 boys and 76 girls) vaccinated in Chaoyang Olympic Village Community Health Service Center from July 2016 to December 2018 were included. Questionnaire survey was designed to investigate the vaccination coverage rate and associated adverse events. Read More

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http://dx.doi.org/10.3760/cma.j.cn112140-20200108-00016DOI Listing

Fatal Mumps Myocarditis Associated with Left Ventricular Non-Compaction.

Am J Case Rep 2020 Mar 30;21:e921177. Epub 2020 Mar 30.

Department of Forensic Medicine, Kyoto University Graduate School of Medicine, Kyoto City, Kyoto, Japan.

BACKGROUND Myocarditis is a rare but potentially fatal complication of mumps virus infection. Left ventricular non-compaction (LVNC) is a rare congenital abnormality that can lead to development of low cardiac output, cardiac dysfunction, arrhythmias, or sudden cardiac death. To the best of our knowledge, no autopsy cases of mumps myocarditis with LVNC have been reported in the literature. Read More

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http://dx.doi.org/10.12659/AJCR.921177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162560PMC

Infection-Associated Opsoclonus: A Retrospective Case Record Analysis and Review of Literature.

J Child Neurol 2020 Jun 27;35(7):480-484. Epub 2020 Mar 27.

Pediatric Neurology Unit, Department of Pediatrics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Opsoclonus, an uncommon clinical sign, and is often described in the context of opsoclonus myoclonus ataxia syndrome (OMAS). OMAS may be paraneoplastic or postinfectious. However, opsoclonus with or without OMAS may occur in association with a wide gamut of infections. Read More

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http://dx.doi.org/10.1177/0883073820911327DOI Listing
June 2020
1.666 Impact Factor

Transcriptomic profiling of different responder types in adults after a Priorix® vaccination.

Vaccine 2020 Apr 9;38(16):3218-3226. Epub 2020 Mar 9.

AUDACIS, Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing, University of Antwerp, Antwerp, Belgium; Centre for the Evaluation of Vaccination (CEV), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.

Thanks to the recommendation of a combined Measles/Mumps/Rubella (MMR) vaccine, like Priorix®, these childhood diseases are less common now. This is beneficial to limit the spread of these diseases and work towards their elimination. However, the measles, mumps and rubella antibody titers show a large variability in short- and long-term immunity. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.03.004DOI Listing

Combating vaccine hesitancy and other 21st century social determinants in the global fight against measles.

Curr Opin Virol 2020 Feb 26;41:1-7. Epub 2020 Feb 26.

Department of Health Promotion & Community Health Sciences, Texas A&M School of Public Health, College Station, Texas, USA. Electronic address:

The year 2019 marked the return of measles after almost two decades of unprecedented successes in global vaccination programs. Measles transmission due to sharp declines in measles-mumps-rubella (MMR) vaccination coverage is now widespread among nations that previously saw impressive public health gains including Philippines, DR Congo, Madagascar, Samoa, many in Europe, and the United States and Venezuela in the Americas. Key determinants include the interruption of vaccine health systems due to war, conflict, and political instability; food insecurity and urbanization; and an increasingly globalized vaccine hesitancy or antivaccine movement. Read More

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http://dx.doi.org/10.1016/j.coviro.2020.01.001DOI Listing
February 2020

Comparison of the Seroprevalence of Measles Antibodies among Healthcare Workers in Two Korean Hospitals in 2019.

Infect Chemother 2020 Mar 21;52(1):93-97. Epub 2020 Jan 21.

Department of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea.

We performed a point seroprevalence survey of measles among healthcare workers (HCWs) at two Korean teaching hospitals in 2019. A total of 2,830 HCWs underwent an antibody test. The overall seropositivity of measles was 93. Read More

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http://dx.doi.org/10.3947/ic.2020.52.1.93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113453PMC

Live attenuated MMR/V booster vaccines in children with rheumatic diseases on immunosuppressive therapy are safe: Multicenter, retrospective data collection.

Vaccine 2020 Feb 24;38(9):2198-2201. Epub 2020 Jan 24.

Department of Allergology, Rheumatology and Clinical Immunology, University Children's Hospital, University Medical Centre Ljubljana, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Purpose: To collect retrospective data of patients with Juvenile Idiopathic Arthritis (JIA) and other rheumatic diseases who received live attenuated booster measles-mumps-rubella (MMR) or measles-mumps-rubella-varicella (MMR/V) during treatment with immunosuppressive therapy.

Results: Data from 13 pediatric rheumatology centers in 10 countries, including 234 patients, were collected. Mean age at diagnosis was 5 ± 2. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.01.037DOI Listing
February 2020

Diagnosing inborn error of immunity following the presentation of a complicated acquired infection after MMRV vaccine administration.

BMJ Case Rep 2020 Jan 21;13(1). Epub 2020 Jan 21.

Paediatric Critical Care Medicine, Shaikh Khalifa Medical City, Abu Dhabi, United Arab Emirates

Live vaccine-acquired infection should attest for the occurrence of inborn errors of immunity. Autosomal recessive immunodeficiency 31B, a result of a signal transducer and activator of transcription 1 genetic mutation, results in defected interferon pathways: interferon alpha/beta and interferon gamma. These interferons are crucial for the defence against viral and mycobacterial infections. Read More

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http://dx.doi.org/10.1136/bcr-2019-233063DOI Listing
January 2020

Vaccination Programs for Adults in Europe, 2019.

Vaccines (Basel) 2020 Jan 20;8(1). Epub 2020 Jan 20.

Department for Interventions in Health Care Facilities, National Organization of Public Health, 15123 Athens, Greece.

Background: While all European countries implement vaccination programs for children, there are gaps in terms of vaccination programs for adults.

Methods: We studied the 2019 vaccination policies for adults in 42 European countries.

Results: Vaccination programs for adults were in place in all countries. Read More

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http://dx.doi.org/10.3390/vaccines8010034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157239PMC
January 2020

Vaccination rate and immunity of children and adolescents with inflammatory bowel disease or autoimmune hepatitis in Germany.

Vaccine 2020 02 24;38(7):1810-1817. Epub 2019 Dec 24.

University Medical Center Ulm, Department of Pediatrics and Adolescent Medicine, Ulm, Germany. Electronic address:

Background And Aims: Immunosuppressed patients are at risk of severe infections with vaccination preventable diseases. We evaluated vaccination rate and immunity of children and adolescents with inflammatory bowel disease (IBD) and autoimmune hepatitis (AIH).

Methods: Immunization rate of 329 children with IBD (n = 300) and AIH (n = 29) was assessed in seven German centres using vaccination certificates, history of chicken pox and by determining anti-varicella zoster virus (VZV) and anti-measles IgG antibodies. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.12.024DOI Listing
February 2020
3.624 Impact Factor

The 2016 California policy to eliminate nonmedical vaccine exemptions and changes in vaccine coverage: An empirical policy analysis.

PLoS Med 2019 12 23;16(12):e1002994. Epub 2019 Dec 23.

Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America.

Background: Vaccine hesitancy, the reluctance or refusal to receive vaccination, is a growing public health problem in the United States and globally. State policies that eliminate nonmedical ("personal belief") exemptions to childhood vaccination requirements are controversial, and their effectiveness to improve vaccination coverage remains unclear given limited rigorous policy analysis. In 2016, a California policy (Senate Bill 277) eliminated nonmedical exemptions from school entry requirements. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927583PMC
December 2019

Antibodies against measles and rubella virus among different age groups in Thailand: A population-based serological survey.

PLoS One 2019 26;14(11):e0225606. Epub 2019 Nov 26.

Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Measles and rubella are highly contagious viral diseases transmitted via respiratory secretions and aerosolized droplets. Thailand has implemented universal vaccination against measles using the monovalent measles (M) or the trivalent measles-mumps-rubella (MMR) vaccine for the past 30 years. Nevertheless, incidence of measles and rubella remains in some parts of the country. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225606PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879141PMC

Seroprevalence of measles, mumps, and rubella and genetic characterization of mumps virus in Khartoum, Sudan.

Int J Infect Dis 2020 Feb 20;91:87-93. Epub 2019 Nov 20.

Infectious Diseases Research Unit, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg. Electronic address:

Background: In Sudan, neither mumps nor rubella vaccines are currently used and comprehensive data on the seroepidemiology of measles, mumps, and rubella (M.M.R), as well as information about circulating mumps virus genotypes, are lacking. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.11.019DOI Listing
February 2020
4 Reads

Congenital viral infections in England over five decades: a population-based observational study.

Lancet Infect Dis 2020 02 7;20(2):220-229. Epub 2019 Nov 7.

Unit of Health-Care Epidemiology, Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, UK; National Institute for Health Research Oxford Biomedical Research Centre, Oxford, UK.

Background: Congenital viral infections cause substantial long-term morbidity but population-based data about diagnosis rates are scarce. The aim of this study was to assess the long-term trends in congenital viral infections in England and to report on how the rates of these infections might have changed with improved methods for detection, the introduction of the two-dose measles-mumps-rubella (MMR) vaccine in 1996, and the implementation of the Newborn Hearing Screening Programme (NHSP) in 2006.

Methods: For this population-based, observational cohort study, we used national and regional hospitalisation data from 1968 to 2016 in England (Hospital In-Patient Enquiry, Hospital Episode Statistics, and Oxford Record Linkage Study) to calculate annual rates of hospital discharges coded with-and individuals aged younger than 1 month diagnosed with-congenital cytomegalovirus, herpes simplex virus (HSV), varicella zoster virus (VZV), and rubella. Read More

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http://dx.doi.org/10.1016/S1473-3099(19)30416-5DOI Listing
February 2020

Vaccinations and Immunization Status in Pediatric Inflammatory Bowel Disease: A Multicenter Study From the Pediatric IBD Porto Group of the ESPGHAN.

Inflamm Bowel Dis 2019 Nov 5. Epub 2019 Nov 5.

Department of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II," Napoli, Italy; Napoli, Italy.

Background: Vaccine-preventable diseases and opportunistic infections in pediatric inflammatory bowel disease (IBD) are increasingly recognized issues. The aims of this study were to evaluate vaccinations, immunization status, and consequent therapeutic management in children with IBD and to analyze the differences among patients diagnosed before (Group 1) and after June 2012 (Group 2).

Methods: This was a multicenter, retrospective cohort investigation. Read More

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http://dx.doi.org/10.1093/ibd/izz264DOI Listing
November 2019
1 Read

Measles, Mumps, And Communion: A Vision For Vaccine Policy.

Health Aff (Millwood) 2019 11;38(11):1944-1947

Joshua T. B. Williams ( Joshua. org ) is a general pediatrician at Denver Health Medical Center and an assistant professor of pediatrics at the University of Colorado School of Medicine, in Denver, Colorado. He thanks Annie Dominguez, Abraham Nussbaum, and Romana Hasnain-Wynia for their thoughtful and constructive feedback on earlier versions of this essay.

A pediatrician offers a vision for vaccine policy that promotes public health while respecting religious beliefs. Read More

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http://dx.doi.org/10.1377/hlthaff.2019.00446DOI Listing
November 2019
1 Read

Infectious vaccine-derived rubella viruses emerge, persist, and evolve in cutaneous granulomas of children with primary immunodeficiencies.

PLoS Pathog 2019 10 28;15(10):e1008080. Epub 2019 Oct 28.

Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.

Rubella viruses (RV) have been found in an association with granulomas in children with primary immune deficiencies (PID). Here, we report the recovery and characterization of infectious immunodeficiency-related vaccine-derived rubella viruses (iVDRV) from diagnostic skin biopsies of four patients. Sequence evolution within PID hosts was studied by comparison of the complete genomic sequences of the iVDRVs with the genome of the vaccine virus RA27/3. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837625PMC
October 2019

Measles Maternal Antibodies With Low Avidity Do Not Interfere With the Establishment of Robust Quantity and Quality Antibody Responses After the Primary Dose of Measles, Mumps, and Rubella Vaccine Administered at 12-Months of Age.

J Pediatric Infect Dis Soc 2019 Oct 23. Epub 2019 Oct 23.

Department of Pediatrics, Stanford University Medical School, Stanford, California, USA.

In this study, we illustrate, for the first time, that preexisting low-avidity neutralizing measles maternal antibodies do not interfere with the development of high concentrations of high-avidity measles antibodies in children immunized at age 12 months. This suggests that the quality of measles maternal antibodies, rather than the quantity, impacts immunogenicity of primary measles immunization. Read More

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http://dx.doi.org/10.1093/jpids/piz074DOI Listing
October 2019

Vaccination of healthcare personnel in Europe: Update to current policies.

Vaccine 2019 12 14;37(52):7576-7584. Epub 2019 Oct 14.

Director, Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN, United States.

We investigated and compared current national vaccination policies for health-care personnel (HCP) in Europe with results from our previous survey. Data from 36 European countries were collected using the same methodology as in 2011. National policies for HCP immunization were in place in all countries. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.09.061DOI Listing
December 2019
2 Reads

Antibody response to vaccination after haematopoietic cell transplantation in children using a reduced dose schedule-A retrospective cohort study.

Pediatr Transplant 2020 02 16;24(1):e13599. Epub 2019 Oct 16.

The Department of Paediatrics and Adolescent Medicine, Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Children receiving HCT loose protective immunity to vaccines received pre-HCT. Therefore, revaccination post-HCT is of major importance. In Denmark, a vaccination schedule with fewer doses post-HCT has been used, including two doses for diphtheria, tetanus, polio, measles, mumps, and rubella, and one dose only for Haemophilus influenzae type B. Read More

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http://dx.doi.org/10.1111/petr.13599DOI Listing
February 2020
2 Reads

Measles re-emerges and recommendation of vaccination.

J Chin Med Assoc 2020 Jan;83(1):5-7

Department of Pediatrics, Cheng-Hsin General Hospital, Taipei, Taiwan, ROC.

Measles is a highly infectious viral illness and is one of the world's most contagious diseases that can affect all people if they have not been vaccinated or have not had it before. Before measles vaccine became available in 1963, major epidemic occurred approximately every 2 to 3 years and thus 99% of the people were thought to have been infected naturally with measles virus and got immune for life. In 2000, measles was declared eliminated from the United States, and yet 1215 cases have been reported from 30 states as of August 22, 2019. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000210DOI Listing
January 2020
3 Reads

Recurrent immune thrombocytopenia following different vaccines.

BMJ Case Rep 2019 Sep 20;12(9). Epub 2019 Sep 20.

Department of Pediatrics, The University of British Columbia, Vancouver, British Columbia, Canada.

A boy developed immune thrombocytopenia 2 weeks after receiving his measles-mumps-rubella and varicella vaccines at 12 months of age. He then had a recurrent episode 1 week after the booster doses of his quadrivalent diphtheria-tetanus-pertussis-polio, pneumococcal and meningococcal group C vaccines at 5 years of age. On both the occasions he required hospitalisation and treatment with intravenous immunoglobulin. Read More

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http://dx.doi.org/10.1136/bcr-2019-231260DOI Listing
September 2019
4 Reads

The Effect of Maternal Immunisation During Pregnancy on Infant Vaccine Responses.

EClinicalMedicine 2019 Aug 26;13:21-30. Epub 2019 Jul 26.

Department of Paediatrics, The University of Melbourne, Parkville, Australia.

Introduction: Immunisation during pregnancy to protect infants against tetanus, pertussis and influenza is recommended in many countries. However, maternal antibodies can interfere with infant vaccine responses. We investigated the effect of antenatal diphtheria-tetanus-acellular pertussis (dTpa) and trivalent inactivated influenza (TIV) immunisation on specific and heterologous antibody responses to routine immunisations given in the first year of life. Read More

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http://dx.doi.org/10.1016/j.eclinm.2019.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733996PMC
August 2019
5 Reads

Live vaccines after pediatric solid organ transplant: Proceedings of a consensus meeting, 2018.

Pediatr Transplant 2019 11 9;23(7):e13571. Epub 2019 Sep 9.

Division of Infectious Diseases, Department of Paediatrics, Transplant and Regenerative Medicine Centre, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Growing evidence suggests receipt of live-attenuated viral vaccines after solid organ transplant (SOT) has occurred and is safe and needed due to lapses in herd immunity. A 2-day consortium of experts in infectious diseases, transplantation, vaccinology, and immunology was held with the objective to review evidence and create expert recommendations for clinicians when considering live viral vaccines post-SOT. For consideration of VV and MMR post-transplant, evidence exists only for kidney and liver transplant recipients. Read More

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http://dx.doi.org/10.1111/petr.13571DOI Listing
November 2019
5 Reads
1.630 Impact Factor

Preventing Measles in Immunosuppressed Cancer and Hematopoietic Cell Transplantation Patients: A Position Statement by the American Society for Transplantation and Cellular Therapy.

Biol Blood Marrow Transplant 2019 11 5;25(11):e321-e330. Epub 2019 Aug 5.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Pediatrics, Seattle Children's Hospital/University of Washington School of Medicine, Seattle, Washington. Electronic address:

Until recently, measles exposures were relatively rare and so, consequently, were an afterthought for cancer patients and/or blood and marrow transplant recipients and their providers. Declines in measles herd immunity have reached critical levels in many communities throughout the United States due to increasing vaccine hesitancy, so that community-based outbreaks have occurred. The reemergence of measles as a clinical disease has raised serious concerns among immunocompromised patients and those who work within the cancer and hematopoietic cell transplantation (HCT) community. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.07.034DOI Listing
November 2019
2 Reads

Measles-Mumps-Rubella Vaccination in Children with Food Allergy.

Authors:
Anju Aggarwal

Indian J Pediatr 2019 10 7;86(10):883-884. Epub 2019 Aug 7.

Department of Pediatrics, University College of Medical Sciences and Guru Tegh Bahadur Hospital, New Delhi, 110095, India.

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http://dx.doi.org/10.1007/s12098-019-03050-yDOI Listing
October 2019
5 Reads

Long-term preservation of measles and rubella specific-IgG antibodies in children with enthesitis related arthritis on anti-TNFα treatment: a prospective controlled study.

Rheumatology (Oxford) 2019 09;58(9):1686-1688

Infectious Diseases Unit, Second Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, P. & A. Kyriakou Children's Hospital, Athens, Greece.

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http://dx.doi.org/10.1093/rheumatology/kez096DOI Listing
September 2019
3 Reads

Measles: Breakouts and Breakthroughs.

J Pediatric Infect Dis Soc 2019 09;8(4):289-290

Emeritus Professor of Pediatrics, University of Pennsylvania, Vaxconsult, Doylestown, Pennsylvania.

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http://dx.doi.org/10.1093/jpids/piz043DOI Listing
September 2019
2 Reads

Reevaluating immunization delays after red blood cell transfusion.

Transfusion 2019 09 4;59(9):2806-2811. Epub 2019 Jul 4.

Department of Pediatrics, CHU Sainte-Justine, Montreal, Quebec, Canada.

Background: Current American and Canadian guidelines recommend delaying live vaccine immunization by 5 to 6 months after transfusion of red blood cells (RBCs) due to potential interference by serum antibodies. Due to lack of data, the recommendations may be unfounded and prevent valuable vaccination opportunities for children with frequent blood transfusions. The primary aim of this study was to determine measles, mumps, rubella (MMR) vaccine immunogenicity in patients chronically transfused with RBCs. Read More

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http://dx.doi.org/10.1111/trf.15433DOI Listing
September 2019
8 Reads

Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines.

J Exp Med 2019 09 3;216(9):2057-2070. Epub 2019 Jul 3.

Department of Microbiology, Immunology and Transplantation, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium.

Vaccination against measles, mumps, and rubella (MMR) and yellow fever (YF) with live attenuated viruses can rarely cause life-threatening disease. Severe illness by MMR vaccines can be caused by inborn errors of type I and/or III interferon (IFN) immunity (mutations in , , or ). Adverse reactions to the YF vaccine have remained unexplained. Read More

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http://dx.doi.org/10.1084/jem.20182295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719432PMC
September 2019
12 Reads
12.515 Impact Factor

Measles, mumps, rubella (vaccine) and varicella vaccines in pediatric liver transplant: An initial analysis of post-transplant immunity.

Pediatr Transplant 2019 08 20;23(5):e13490. Epub 2019 Jun 20.

Section of Infectious Diseases, Transplant Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas.

Varicella and measles infection represents a significant source of morbidity and mortality for pediatric LT recipients. We evaluated the prevalence and correlates of post-transplant immunity in pediatric LT recipients previously immunized against measles (n = 72) and varicella (n = 67). Sixteen of seventy-two (22%) patients were measles non-immune, and 42/67 (63%) were varicella non-immune after LT. Read More

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http://dx.doi.org/10.1111/petr.13490DOI Listing
August 2019
15 Reads

Trends in varicella and mumps vaccination rates in children under 3 years of age in a tertiary children's hospital in Japan.

Pediatr Int 2019 Sep;61(9):882-888

Division of Infectious Diseases, Department of Pediatrics, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.

Background: In Japan, the voluntary vaccination rate is not known accurately. Although two doses of the measles and rubella vaccines have been part of the universal vaccine program since 2006, the varicella vaccine was added in October 2014 while the mumps vaccine still remains voluntary. The aim of this study was to evaluate trends in the live measles, rubella, varicella and mumps vaccination rates in Japan. Read More

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http://dx.doi.org/10.1111/ped.13916DOI Listing
September 2019
8 Reads

High level antibodies to TORCH in the IVIG preparation from Taiwanese.

J Chin Med Assoc 2019 Jun;82(6):510-514

Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.

Background: Congenital TORCH (toxoplasmosis, other viruses [varicella-zoster virus, VZV, etc.], rubella, cytomegalovirus [CMV], Herpes simplex virus [HSV]) infections are major causes of prenatal, perinatal, and postnatal morbidity and mortality. Although treatment or prevention strategies are available for these pathogens, all drugs may not be safe during the pregnancy. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000043DOI Listing
June 2019
22 Reads

The influence of neonatal Bacille Calmette-Guérin (BCG) immunisation on heterologous vaccine responses in infants.

Vaccine 2019 06 29;37(28):3735-3744. Epub 2019 May 29.

Department of Paediatrics, The University of Melbourne, Parkville, Australia; Infectious Diseases Research Group, Murdoch Children's Research Institute, Parkville, Australia; Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Australia. Electronic address:

Introduction: Bacillus Calmette-Guérin vaccine (BCG), one of the most widely used vaccines, does not only provide protection against tuberculosis and other mycobacterial infections, but also has non-specific (heterologous) immunomodulatory effects. In participants in a randomised trial, we investigated the effect of neonatal BCG immunisation on antibody responses to routine infant vaccines given in the first year of life.

Methods: Antibodies against antigens in the diphtheria, tetanus, pertussis, polio, Haemophilus influenzae type b (Hib), and the 13-valent pneumococcal conjugate vaccines were measured in 91 (45 BCG-vaccinated, 46 BCG-naïve) infants one month after, and in 310 (169 BCG-vaccinated, 141 BCG-naïve) infants seven months after immunisation at 6 weeks, 4 and 6 months of age. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.03.016DOI Listing
June 2019
18 Reads

Child and adolescent health in northwestern Syria: findings from Healthy-Syria 2017 study.

Avicenna J Med 2019 Apr-Jun;9(2):61-74

Department of Pediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Objectives: Since the uprising in 2011, there has been limited health-care data from inside Syria in the academic literature. This study aims to provide an updated account of pediatric health needs in the northwestern part of Syria; this should help inform the management and delivery of health-care services in this population.

Methods: This is a prospective study, using a data registry, of all pediatric patients seen in a single center in northwestern Syria, between February and December 2017. Read More

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http://dx.doi.org/10.4103/ajm.AJM_184_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530271PMC
May 2019
29 Reads

A Third Dose of Measles-Mumps-Rubella Vaccine to Improve Immunity Against Mumps in Young Adults.

J Infect Dis 2020 Mar;221(6):902-909

Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven.

Background: Waning of vaccine-induced immunity is considered to play a central role in the reemergence of mumps among vaccinated young adults. The aim of the present study was to investigate antibody responses and safety of a third dose of measles-mumps-rubella vaccine (MMR-3) in 150 young adults. Antibody levels were related to a surrogate of protection based on preoutbreak serum antibody levels in 31 persons with and 715 without serological evidence of mumps. Read More

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http://dx.doi.org/10.1093/infdis/jiz188DOI Listing
March 2020
6 Reads

Does Food Allergy Require Any Change in Measles-Mumps-Rubella Vaccination?

Indian J Pediatr 2019 10 18;86(10):915-920. Epub 2019 May 18.

Department of Pediatrics, Şişli Hamidiye Etfal Education and Research Hospital, Kazım Karabekir Paşa Mahallesi, Bahçeköy cad. No: 62,34453, Sarıyer/İstanbul, Turkey.

Objectives: To determine the allergic reactions that develop after Measles and Measles-Mumps-Rubella (MMR) vaccination, and whether any delay in the timing of vaccination occurs in children with food allergy.

Methods: Children with food allergy who were admitted to the Şişli Hamidiye Etfal Training and Research Hospital Healthy Child Clinic between 1st January 2015 and 30th June 2018 for Measles or MMR vaccination were studied retrospectively. Their age, delayed days of vaccination, the types of allergic food, the results of the specific IgE and skin tests, and any reaction after the vaccination were recorded. Read More

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http://dx.doi.org/10.1007/s12098-019-02981-wDOI Listing
October 2019
12 Reads

Measles-Rubella Campaign: Could Things Have Been Done Differently?

Authors:
Mukesh Sanklecha

Indian Pediatr 2019 04;56(4):335

Department of Pediatrics, Bombay Hospital Institute of Medical Sciences, Mumbai, Maharashtra, India.

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April 2019
20 Reads

Vaccination Status in Pediatric Solid-Organ Transplant Recipients and Their Household Members.

Exp Clin Transplant 2019 08 2;17(4):429-434. Epub 2019 May 2.

From the Department of Pediatrics, Medical University of Innsbruck, Innsbruck, Austria.

Objectives: Vaccine-preventable diseases remain a major cause of morbidity and mortality in solid-organ transplant candidates and recipients. Newer recommendations include vaccination of all household members to create a herd immunity around the transplant recipient. This study evaluated the vaccination status of pediatric solid-organ transplant recipients and their household members. Read More

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http://dx.doi.org/10.6002/ect.2018.0184DOI Listing
August 2019
12 Reads

Missed Opportunities for Rotavirus Vaccination.

Pediatrics 2019 05;143(5)

Epidemiology, and

Background: Rotavirus remains an important cause of gastroenteritis and has been associated with the hospitalization of 34 to 53 per 10 000 children <5 years of age in the United States annually from 2008 to 2012. Rotavirus vaccines are underused compared with other routine vaccines. We describe rotavirus vaccine coverage and missed opportunities for rotavirus vaccination. Read More

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http://dx.doi.org/10.1542/peds.2018-2498DOI Listing
May 2019
30 Reads