974 results match your criteria Pediatrics Mumps

Temporal Trends in Undervaccination: A Population-Based Cohort Study.

Am J Prev Med 2021 07 30;61(1):64-72. Epub 2021 Apr 30.

Institute for Health Research, Kaiser Permanente Colorado, Aurora, Colorado; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado.

Introduction: Monitoring the trends in undervaccination, including that because of parental vaccine refusal or delay, can inform public health responses directed at improving vaccine confidence and vaccination coverage.

Methods: A retrospective cohort study was conducted in the Vaccine Safety Datalink. The cohort included all children born in 2004-2017 with ≥3 well-child visits between ages 2 and 23 months. Read More

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Live Virus Vaccination of Pediatric Solid-Organ Transplant Candidates Within One Month Prior to Transplantation: A Multi-Center Experience.

Transpl Infect Dis 2021 Jun 18:e13667. Epub 2021 Jun 18.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.

Background: Solid organ transplant (SOT) recipients are at increased risk of vaccine preventable illness due to the high degree of immunosuppression required following transplantation. The current recommendation is to vaccinate with live attenuated vaccines, including Measles, Mumps and Rubella (MMR) and Varicella (VAR) vaccines, at least 4 weeks prior to transplant. However, data to support the time interval between vaccine and transplant is limited. Read More

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Measles, mumps, rubella, varicella and influenza vaccination in children with acute food protein-induced enterocolitis syndrome triggered by egg.

Clin Exp Allergy 2021 Jun 18. Epub 2021 Jun 18.

Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy.

Acute food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy characterized by the onset of delayed repetitive and projectile vomiting accompanied by other clinical manifestations such as pallor, hypotonia, lethargy, hypothermia and/or diarrhea (1). Acute FPIES can be classified as classic or atypical based on the absence or presence of sensitization to the trigger food (2). Read More

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Review of the measles epidemic in children from Central Eastern Europe in the third millennium.

Exp Ther Med 2021 Aug 2;22(2):816. Epub 2021 Jun 2.

Department of Paediatrics, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Measles is an extremely contagious viral disease. Even though a safe vaccine exists for this disease, it remains one of the leading causes of mortality and morbidity in infants and young children. We aimed to create a retrospective descriptive study in which to analyze the evolution of the measles epidemic at the European level. Read More

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Mandatory Infant Vaccinations in France During the COVID-19 Pandemic in 2020.

Front Pediatr 2021 28;9:666848. Epub 2021 May 28.

EPI-PHARE (French National Agency for Medicines and Health Products Safety, ANSM; and French National Health Insurance, CNAM), Saint-Denis, France.

To describe changes in the dispensation of 11 mandatory vaccines to infants in France during the COVID-19 pandemic in 2020, considering the priming doses and boosters separately. With data from the French national health database, all dispensations of priming doses and boosters of 11 mandatory vaccines [penta/hexavalent, measles mumps rubella (MMR), meningococcal conjugate type-C (Men-C-C), 13-valent pneumococcal conjugate (PCV13)] for infants ≤24 months old were aggregated by 4-week periods in 2020. Expected counts in 2020 were estimated according to counts in 2019 weighted by a ratio considering the level of vaccine dispensation before the pandemic onset in 2020. Read More

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Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity.

J Allergy Clin Immunol 2021 May 24. Epub 2021 May 24.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, University Hospital Erlangen, Erlangen, Germany.

Background: Rubella virus-induced granulomas have been described in patients with various inborn errors of immunity. Most defects impair T-cell immunity, suggesting a critical role of T cells in rubella elimination. However, the molecular mechanism of virus control remains elusive. Read More

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Risk of Vaccine-Preventable Infections in Swiss Adults with Inflammatory Bowel Disease.

Digestion 2021 May 10:1-9. Epub 2021 May 10.

Department of Pediatrics, Pediatric Infectious Disease Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

Background: Patients with inflammatory bowel disease (IBD) have a higher risk of infection and are frequently not up to date with their immunizations.

Objectives: This study aims to review vaccination status and evaluate whether age, disease type, or treatment regimen could predict the absence of seroprotection against selected vaccine-preventable infection in adults with IBD.

Methods: Cross-sectional study using questionnaire, immunization records review, and assessment of tetanus-specific, varicella-specific, and measles-specific immunoglobulin G concentrations. Read More

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Changes and remaining challenges for the Japanese immunization program: Closing the vaccine gap.

Vaccine 2021 05 28;39(22):3018-3024. Epub 2021 Apr 28.

Kawasaki City Institute for Public Health, 3-25-13 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan.

The Japanese immunization program has made considerable progress since 2009: several new vaccines have been introduced and most are included in the National Immunization Program (NIP). In October 2020, the Japanese law on immunization was revised, which resulted in a few laudable achievements. First, rotavirus vaccines were added to the NIP, 10 years after their introduction, and noteworthy studies of vaccine effectiveness and the incidence of intussusception in Japanese children were published. Read More

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Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019.

Euro Surveill 2021 Apr;26(17)

Department of Paediatrics and Adolescent Medicine, The Juliane Marie Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

BackgroundHealthcare workers (HCW) have been identified as index cases in disease outbreaks of vaccine-preventable diseases (VPD) in hospitals.AimWe investigated whether Danish paediatric HCW were protected against selected serious VPD.MethodsWe included 90% of staff members from two paediatric departments. Read More

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Ten-year follow-up on efficacy, immunogenicity and safety of two doses of a combined measles-mumps-rubella-varicella vaccine or one dose of monovalent varicella vaccine: Results from five East European countries.

Vaccine 2021 05 12;39(19):2643-2651. Epub 2021 Apr 12.

GSK, Wavre, Belgium. Electronic address:

Background: We assessed the 10-year efficacy, immunogenicity and safety of two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV) or one dose of a monovalent varicella vaccine (V) in children from Czech Republic, Lithuania, Poland, Romania and Slovakia.

Methods: This was a phase IIIB follow-up of an observer-blind, randomized, controlled trial (NCT00226499). In phase A, healthy children aged 12-22 months from 10 European countries were randomized in a 3:3:1 ratio to receive two doses of MMRV (MMRV group), one dose of MMR followed by one dose of V (MMR + V group), or two doses of MMR (MMR; control group), 42 days apart. Read More

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Immunity to varicella, measles, and mumps in patients evaluated for lung transplantation.

Am J Transplant 2021 Apr 11. Epub 2021 Apr 11.

Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA.

Vaccine-preventable viral infections are associated with increased risk of morbidity and mortality in post-transplant patients on immunosuppression regimens. Therefore, we studied rates of immunity against vaccine-preventable viruses in lung transplantation (LTx) candidates and their associations with underlying lung disease and clinical characteristics. We retrospectively studied 1025 consecutive adult patients who underwent first-time evaluation for LTx at a single center between January 2016 and October 2018. Read More

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An Immune Recovery-Based Revaccination Protocol for Pediatric Hematopoietic Stem Cell Transplant Recipients: Revaccination Outcomes Following Pediatric HSCT.

Transplant Cell Ther 2021 Apr 28;27(4):317-326. Epub 2021 Jan 28.

Division of Pediatric Infectious Diseases, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado.

Following hematopoietic stem cell transplant (HSCT), patients are at increased risk of vaccine-preventable diseases (VPDs) and experience worse outcomes of VPDs compared to immunocompetent patients. Therefore, patients are routinely vaccinated post-HSCT to restore VPD immunity. Published guidelines recommend revaccination based on time post-HSCT, although optimal revaccination timing and the value of using other clinical and laboratory variables to guide revaccination remain unclear. Read More

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Immunogenicity and safety of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine administered concomitantly with other paediatric vaccines in toddlers: a phase III randomised study.

Epidemiol Infect 2021 Apr 5;149:e90. Epub 2021 Apr 5.

Global Clinical Sciences, Sanofi Pasteur, Swiftwater, PA, USA.

Invasive meningococcal disease has high morbidity and mortality, with infants and young children among those at greatest risk. This phase III, open-label, randomised study in toddlers aged 12-23 months evaluated the immunogenicity and safety of meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT), a tetanus toxoid conjugated vaccine against meningococcal serogroups A, C, W and Y, when coadministered with paediatric vaccines (measles, mumps and rubella [MMR]; varicella [V]; 6-in-1 combination vaccine against diphtheria, tetanus, pertussis, polio, hepatitis B and Haemophilus influenzae type b [DTaP-IPV-HepB-Hib] and pneumococcal conjugate vaccine [PCV13])(NCT03205371). Immunogenicity to each meningococcal serogroup was assessed by serum bactericidal antibody assay using human complement (hSBA). Read More

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Trends in voluntary vaccination coverage in a Japanese city.

Pediatr Int 2021 Mar 29. Epub 2021 Mar 29.

Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

Background: Large numbers of patients with diseases preventable by voluntary vaccines have been reported in Japan. However, it is difficult to analyze the impact of voluntary vaccination on disease prevention, as the governments do not aggregate the number of recipients of vaccines that are not included in the national immunization program. This study investigated the association between the coverage rates of two voluntary vaccines (rotavirus and mumps vaccines) and the incidence of the diseases preventable by these vaccines. Read More

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Vaccine hesitancy and reported non-vaccination in an Irish pediatric outpatient population.

Eur J Pediatr 2021 Mar 27. Epub 2021 Mar 27.

Department of General Pediatrics, CHI at Temple Street, Dublin, Ireland.

Vaccine hesitancy is defined as a delay in acceptance, or refusal, of vaccines, despite availability. It is a complex and context specific phenomenon and identified as a global health priority. The "Parent Attitudes about Childhood Vaccines" (PACV) questionnaire is a validated tool for identifying vaccine hesitancy. Read More

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Vaccine coverage among children with epilepsy in two Canadian provinces: A Canadian immunization research network study.

Vaccine 2021 04 13;39(15):2117-2123. Epub 2021 Mar 13.

Institute for Clinical Evaluative Sciences, Ottawa, ON, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, ON, Canada.

Objectives: Children with epilepsy are at increased risk of complications from vaccine-preventable infections, yet information on vaccine coverage in these children is scarce. We aimed to compare vaccine coverage among children with epilepsy to children without epilepsy.

Study Design: We conducted a retrospective cohort study including all 2005-2013 births in Manitoba and Ontario, Canada, creating two cohorts: 2-year-olds and 7-year-olds (followed to age 2 and 7 years). Read More

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Clinical Profile and Outcome of Guillain-Barre Syndrome in Pediatric Patients Admitted to a Tertiary Care Centre: A Retrospective Study.

Neurol India 2021 Jan-Feb;69(1):81-84

Department of Pediatrics, Seth G.S. Medical College and KEM Hospital, Parel, Mumbai, Maharashtra, India.

Aims And Objectives: To study clinical profile and outcome in Pediatric Guillain Barre Syndrome (GBS).

Materials And Methods: Retrospective study of 30 patients (age 1 month to 12 years) admitted with GBS enrolled over a period of 2 years (August 2016-July 2018) from Department of Pediatrics of tertiary centre.

Results: Mean age was 5. Read More

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Mumps Antibody Titer in MMR-Vaccinated and Vaccine Naïve Children at a Public Hospital in Delhi.

Indian Pediatr 2021 Feb;58(2):137-139

Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.

Objective: To compare the mumps antibody titers in Measles-Mumps-Rubella (MMR)-vaccinated and vaccine naive children.

Methods: This cross-sectional study was conducted at a tertiary-care public hospital in Delhi from November, 2016 to April, 2018 among 78 healthy children (aged 16 month-12 years) attending the pediatric outpatient department. Serum IgG and IgM rubella antibodies were measured by ELISA for confirmation of MMR vaccination status. Read More

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February 2021

Suboptimal Vaccination Administration in Mothers With Inflammatory Bowel Disease and Their Biologic-Exposed Infants.

Inflamm Bowel Dis 2021 Feb 20. Epub 2021 Feb 20.

Department of Community Health Sciences, University of Calgary, Alberta, Canada.

Background: Pregnant women with inflammatory bowel disease (IBD) are at increased risk of developing complications from vaccine-preventable infections. We investigated the factors influencing vaccine administration in pregnant women with IBD and their infants, in addition to the safety of vaccination in the infants.

Methods: This retrospective cohort study identified individuals from a tertiary referral clinic whose records were linked to a provincial vaccine database. Read More

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February 2021

Hyperbaric Oxygen Therapy for Mumps-Associated Outer Retinitis with Frosted Branch Angiitis.

Ocul Immunol Inflamm 2021 Feb 5:1-4. Epub 2021 Feb 5.

A Department, Hedi Rais Institute of Ophthalmology, Tunis El-Manar University, Tunis, Tunisia.

Purpose: To describe a case of outer retinitis with frosted branch angiitis associated with mumps infection treated with hyperbaric oxygen (HBO) therapy.

Methods: Observational case report.

Case Report: A four-year-old boy with bilateral blindness was diagnosed with necrotizing outer retinitis with frosted branch angiitis associated with serologically confirmed mumps virus infection. Read More

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February 2021

Live attenuated vaccines under immunosuppressive agents or biological agents: survey and clinical data from Japan.

Eur J Pediatr 2021 Jun 1;180(6):1847-1854. Epub 2021 Feb 1.

Department of Development Strategy, Clinical Research Center, National Center for Child Health and Development, Tokyo, Japan.

Live attenuated vaccines are contraindicated for patients on immunosuppressive agents or biological agent, except for live attenuated varicella vaccine, although previous reports showed their effectiveness and safety. This study is the nationwide cross-sectional research about the current utilization of live attenuated vaccines for patients on immunosuppressive agents or biological agents in Japan. We sent questionnaires to pediatric centers and examined whether each institution offered live attenuated vaccines to patients with immunosuppressive agents or biological agents (institutional research). Read More

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Thoughts, beliefs and concepts concerning infectious childhood diseases of physicians practicing homeopathic, anthroposophic and conventional medicine - a qualitative study.

BMC Complement Med Ther 2021 Jan 26;21(1):46. Epub 2021 Jan 26.

Institute for Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin, Luisenstr. 57, 10117, Berlin, Germany.

Background: Physicians who include complementary medicine in their practice are thought to have an understanding of health and disease different from that of colleagues practicing conventional medicine. The aim of this study was to identify and compare the thoughts and concepts concerning infectious childhood diseases (measles, mumps, rubella, chickenpox, pertussis and scarlet fever) of physicians practicing homeopathic, anthroposophic and conventional medicine.

Methods: This qualitative study used semistructured interviews. Read More

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January 2021

Vaccinating Children against Covid-19 - The Lessons of Measles.

N Engl J Med 2021 Feb 20;384(7):589-591. Epub 2021 Jan 20.

From the Department of Journalism, New York University (P.K.), and the Departments of Pediatrics (P.K., A.J.R.) and Microbiology (A.J.R.), and the Division of Pediatric Infectious Diseases (A.J.R.), Grossman School of Medicine, New York University, New York.

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February 2021

A modern measles outbreak: understanding maternal immunity and impact on postpartum vaccination uptake.

Am J Obstet Gynecol MFM 2021 05 13;3(3):100309. Epub 2021 Jan 13.

Department of Obstetrics and Gynecology, New York University Grossman School of Medicine, New York University Langone Health, New York, NY.

Background: In October 2018, a measles (rubeola) outbreak was identified in New York City and Rockland County, and a public health campaign and hospital policy changes were made to increase awareness of the importance of vaccination and increase vaccination rates.

Objective: We describe the prevalence of rubeola immunity in pregnant women and the change in uptake of postpartum measles, mumps, and rubella vaccination before and during the measles outbreak.

Study Design: A multipronged intervention was developed by the health system with the intent of raising awareness of the outbreak, identifying patients at risk of contracting measles during pregnancy, and limiting exposure of inpatients to the disease. Read More

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Suboptimal vaccination coverage of recommended vaccines among French children with recurrent autoinflammatory fever syndromes: a study from the Juvenile Inflammatory Rheumatism cohort.

Clin Rheumatol 2021 Jul 13;40(7):2855-2864. Epub 2021 Jan 13.

Department of General Pediatrics, Versailles Hospital, 177 rue de Versailles, 78150, Le Chesnay, Paris, France.

Introduction/objectives: To determine vaccination coverage among a French cohort of children with recurrent autoinflammatory fever syndromes (RFS).

Method: All RFS children aged 2 to 19 years from the Juvenile Inflammatory Rheumatism cohort and followed at the French Reference Center for Autoinflammatory Diseases, Versailles Hospital, were included in our observational study. Immunisation status at ages 2, 7 and 15 years and at the last outpatient visit was evaluated according to the standard French vaccine schedule and recommended supplementary vaccines for patients with immunosuppressive therapy. Read More

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Modeling human adaptive immune responses with tonsil organoids.

Nat Med 2021 01 11;27(1):125-135. Epub 2021 Jan 11.

Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.

Most of what we know about adaptive immunity has come from inbred mouse studies, using methods that are often difficult or impossible to confirm in humans. In addition, vaccine responses in mice are often poorly predictive of responses to those same vaccines in humans. Here we use human tonsils, readily available lymphoid organs, to develop a functional organotypic system that recapitulates key germinal center features in vitro, including the production of antigen-specific antibodies, somatic hypermutation and affinity maturation, plasmablast differentiation and class-switch recombination. Read More

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January 2021

Infant immunity against viral infections is advanced by the placenta-dependent vertical transfer of maternal antibodies.

Vaccine 2021 Jan 8. Epub 2021 Jan 8.

Division for Experimental Feto-Maternal Medicine, Department of Obstetrics and Prenatal Medicine, University Medical Center of Hamburg-Eppendorf, Germany. Electronic address:

Neonatal passive immunity, derived from transplacental transfer of IgG antibodies from mother to fetus during pregnancy, can mitigate the risk for severe infections in the early postnatal period. Understanding the placenta as the gateway organ in this process, we aimed to evaluate the influence of specific factors modulating the transplacental IgG transfer rate (TPTR) in 141 mother/neonate pairs. We further evaluated the potential health advantage elicited by maternal IgG with regard to respiratory tract infections during infancy and early childhood. Read More

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January 2021

Viral seroprevalence in pediatric kidney transplant recipients.

Turk Pediatri Ars 2020 16;55(4):418-424. Epub 2020 Dec 16.

Division of Pediatric Nephrology, Department of Pediatrics, Akdeniz University Faculty of Medicine, Antalya, Turkey.

Aim: Viral infections commonly affect kidney transplant recipients and may lead to graft failure and death. The aim of this study was to evaluate the antibody seroprevalence against viral agents in kidney transplant recipients.

Material And Methods: The records of children who underwent kidney transplantation between 2008 and 2018 in Akdeniz University Faculty of Medicine were retrospectively reviewed. Read More

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December 2020

Childhood vaccinations: Hidden impact of COVID-19 on children in Singapore.

Vaccine 2021 01 26;39(5):780-785. Epub 2020 Dec 26.

Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore.

Although the direct health impact of Coronavirus disease (COVID-19) pandemic on child health is low, there are indirect impacts across many aspects. We compare childhood vaccine uptake in three types of healthcare facilities in Singapore - public primary care clinics, a hospital paediatric unit, and private paediatrician clinics - from January to April 2020, to baseline, and calculate the impact on herd immunity for measles. We find a 25. Read More

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January 2021