853 results match your criteria Pediatrics Mumps


Protection against varicella with two doses of combined measles-mumps-rubella-varicella vaccine or one dose of monovalent varicella vaccine: 10-year follow-up of a phase 3 multicentre, observer-blind, randomised, controlled trial.

Lancet Infect Dis 2019 Feb 11. Epub 2019 Feb 11.

University of Defence, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic; Charles University, Faculty of Medicine in Hradec Kralove, Department of Social Medicine, Hradec Kralove, Czech Republic.

Background: The duration of protection provided by varicella vaccines is unclear. We assessed the 10-year vaccine efficacy of two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV), one live attenuated varicella vaccine (V) dose given after one measles-mumps-rubella vaccine (MMR) dose (MMR + V), versus two MMR doses (control vaccine) for the prevention of confirmed varicella.

Methods: This was a phase 3b follow-up of an observer-blinded, randomised, controlled trial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14733099183071
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http://dx.doi.org/10.1016/S1473-3099(18)30716-3DOI Listing
February 2019
3 Reads

Early disappearance of maternal anti-measles, mumps, rubella, and varicella antibodies in Indian infants.

Vaccine 2019 Feb 11. Epub 2019 Feb 11.

Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed To Be University), Pune, India. Electronic address:

Background: Immunization of children with vaccines against Measles, Mumps, Rubella, and Varicella (MMRV) is practiced globally with varied recommendations. In India, measles vaccine is administered alone or as MMR at 9 months age. Varicella vaccine is not routinely used. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193011
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http://dx.doi.org/10.1016/j.vaccine.2019.01.043DOI Listing
February 2019
1 Read

Vaccination Against Measles, Mumps, and Rubella in the Light of Current Epidemic Threats: Unjustified Postponement.

Adv Exp Med Biol 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatrics with Clinical Assessment Unit, Warsaw Medical University, Warsaw, Poland.

A worrying increase in the number of measles cases has been noted recently in Poland, which may have to do with a decreasing proportion of children vaccinated against measles, mumps, and rubella (MMR) in the second year of life (<95%). For many years, MMR vaccination in children has been associated with a fear of allergy to eggs. This study seeks to define the reason and justification for postponing MMR vaccination in a population of children referred to the outpatient specialist immunization clinic. Read More

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http://dx.doi.org/10.1007/5584_2019_344DOI Listing
February 2019

Acute disseminated encephalomyelitis: complication of a vaccine preventable disease.

BMJ Case Rep 2018 Dec 27;11(1). Epub 2018 Dec 27.

Department of Virology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory-demyelinating disease of central nervous system. Several viral infections and vaccines act as precipitating factor for ADEM. We report an 8-year-old girl presenting with acute-onset flaccid paraparesis and bilateral painless vision loss. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22571
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http://dx.doi.org/10.1136/bcr-2018-225710DOI Listing
December 2018
10 Reads

The changing epidemiology of mumps in a high vaccination era.

Lancet Infect Dis 2019 Feb 14;19(2):118-119. Epub 2018 Dec 14.

Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA; Wistar Institute, Philadelphia, PA, USA; Vaxconsult LLC, Doylestown, PA, USA.

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http://dx.doi.org/10.1016/S1473-3099(18)30541-3DOI Listing
February 2019
2 Reads

Serologic Status of Routine Childhood Vaccines, Cytomegalovirus, and Epstein-Barr Virus in Children With Inflammatory Bowel Disease.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

Section of Paediatric Gastroenterology, Department of Paediatrics, University of Calgary, Calgary, Alberta, Canada.

Background: Data on the serologic status of childhood vaccines, cytomegalovirus (CMV) and Epstein-Barr virus (EBV), are limited in inflammatory bowel disease (IBD). Therefore, we evaluated vaccine coverage and seroprotection, along with CMV and EBV seropositivity, in pediatric IBD.

Methods: In a cross-sectional study, demographic data, IBD history, vaccine records, and serum for antibodies against measles, mumps, rubella, diphtheria, tetanus, varicella, hepatitis B (HBV), CMV, and EBV were collected from children with IBD. Read More

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http://dx.doi.org/10.1093/ibd/izy366DOI Listing
December 2018
3 Reads

Implementing Universal Varicella Vaccination in Europe: The Path Forward.

Pediatr Infect Dis J 2019 Feb;38(2):181-188

University of Tampere Medical School, Tampere, Finland.

Varicella is a common vaccine-preventable disease that usually presents as a mild disorder but can lead to severe complications. Before the implementation of universal varicella vaccination (UVV) in some European countries, the burden of varicella disease was broadly similar across the region. Despite this, countries adopted heterogeneous varicella vaccination strategies. Read More

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http://dx.doi.org/10.1097/INF.0000000000002233DOI Listing
February 2019
5 Reads

Atypical Kawasaki Disease in a 4 Years Old Child with Mumps.

JNMA J Nepal Med Assoc 2018 Jul-Aug;56(212):811-814

Department of Pediatrics, Kathmandu Medical College Teaching Hospital, Kathmandu, Nepal.

Kawasaki disease is an acute febrile condition seen in children. However, it is also well recognized that some patients do not fulfill the classic diagnostic criteria for the diagnosis of Kawasaki disease. The incomplete form of Kawasaki disease is termed as 'Incomplete KD' or 'Atypical KD'. Read More

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November 2018
1 Read

Effects of a Public Subsidization Program for Mumps Vaccine on Reducing the Disease Burden in Nagoya City, Japan.

Jpn J Infect Dis 2018 Oct 31. Epub 2018 Oct 31.

Department of Public Health, Osaka City University Graduate School of Medicine.

Nagoya City initiated a public subsidization program for mumps vaccination using either Torii- or Hoshino-strains in August 2010. To demonstrate the effects of the program, we used publicly available information from Nagoya City to investigate the changes in immunization rate and numbers of patients who developed post-immunization adverse reactions, including post-vaccinal aseptic meningitis, in the 7 years since its initiation. We also investigated the numbers of mumps patients reported during this period by sentinel sites in a national database. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2018.276DOI Listing
October 2018
2 Reads

secretor genotype and susceptibility to infections and chronic conditions in the ALSPAC cohort.

Wellcome Open Res 2018 25;3:65. Epub 2018 Sep 25.

Medical Research Council Integrative Epidemiology Unit, Avon Longitudinal Study of Parents and Children, Population Health Science, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.

The (fucosyltransferase-2) gene determines blood group secretor status. Being homozygous for the inactive "non-secretor" rs601338(A) allele confers resistance to certain infections (e.g. Read More

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https://wellcomeopenresearch.org/articles/3-65/v1
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http://dx.doi.org/10.12688/wellcomeopenres.14636.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171556.2PMC
September 2018
12 Reads

Hidden diagnosis behind viral infection: the danger of anchoring bias.

BMJ Case Rep 2018 Oct 21;2018. Epub 2018 Oct 21.

Department of General Pediatrics and Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan.

Anchoring bias is one of the most common diagnostic biases that may lead to closed-minded thinking and could result in unnecessary tests, inappropriate patient management and even misdiagnosis. A 4-year-old boy was brought to the emergency department because of shaking chills. On the basis of bilateral swollen preauricular areas, high level of serum amylase and the prevalence of mumps, he initially received a diagnosis of mumps in spite of the shaking chills. Read More

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http://dx.doi.org/10.1136/bcr-2018-226613DOI Listing
October 2018
5 Reads

Hong Kong Institute of Allergy and Hong Kong Society for Paediatric Immunology Allergy & Infectious Diseases joint consensus statement 2018 on vaccination in egg-allergic patients.

Hong Kong Med J 2018 Oct;24(5):527-531

Allergy Centre, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong.

Vaccination of egg-allergic individuals has been a historical concern, particularly for influenza and measles-mumps-rubella-varicella vaccines that are developed in chicken egg embryos or chicken cell fibroblasts. The egg proteins in these vaccines were believed to trigger an immediate allergic reaction in egg-allergic individuals. However, recently published international guidelines have updated their recommendations and now state that these vaccines can be safely administered to egg-allergic individuals. Read More

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http://dx.doi.org/10.12809/hkmj177137DOI Listing
October 2018
8 Reads

Measles: a disease often forgotten but not gone.

Hong Kong Med J 2018 Oct;24(5):512-520

Department of Pediatrics and Department of Laboratory Medicine and Pathology, The University of Alberta, Edmonton, Alberta, Canada.

Measles (rubeola) is a highly contagious vaccine-preventable disease caused by the measles virus-a virus of the family. The illness typically begins with fever, runny nose, cough, and pathognomonic enanthem (Koplik spots) followed by a characteristic erythematous, maculopapular rash. The rash classically begins on the face and becomes more confluent as it spreads cephalocaudally. Read More

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http://dx.doi.org/10.12809/hkmj187470DOI Listing
October 2018
7 Reads

Safety of Anti-TNF-Alpha Therapy During Pregnancy on Long-term Outcome of Exposed Children: A Controlled, Multicenter Observation.

Inflamm Bowel Dis 2018 Sep 20. Epub 2018 Sep 20.

IBD Clinical and Research Center, ISCARE IVF, a.s., Prague, Czech Republic.

Background: Evidence of the impact of in utero exposure to anti-tumor necrosis factor (TNF)-alpha on long-term childhood development is limited. The aim was to assess the impact of in utero exposure to anti-TNF-alpha due to mothers' inflammatory bowel disease (IBD) on long-term postnatal development of exposed children.

Methods: We included consecutive children (≥12 months of age) born to mothers with IBD (2007-2016) treated with anti-TNF-alpha during pregnancy in 3 centers in the Czech Republic. Read More

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http://dx.doi.org/10.1093/ibd/izy294DOI Listing
September 2018
4 Reads
4.464 Impact Factor

Rate of Recurrence of Adverse Events Following Immunization: Results of 19 Years of Surveillance Ii Quebec, Canada.

Pediatr Infect Dis J 2018 Sep 10. Epub 2018 Sep 10.

Department of social and preventive medicine, Laval University, Quebec, Canada.

Background: While adverse events following immunization (AEFI) are frequent, there are limited data on the safety of reimmunizing patients who had a prior AEFI. Our objective was to estimate the rate and severity of AEFI recurrences.

Methods: We analyzed data from the AEFI passive surveillance system in Quebec, Canada that collects information on reimmunization of patients who had a prior AEFI. Read More

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http://Insights.ovid.com/crossref?an=00006454-900000000-9653
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http://dx.doi.org/10.1097/INF.0000000000002162DOI Listing
September 2018
10 Reads

Measles outbreak in a French Roma community in the Provence-Alpes-Côte d'Azur region, France, May to July 2017.

Int J Infect Dis 2018 11 7;76:97-101. Epub 2018 Sep 7.

Aix-Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France;

Objectives: To analyse a measles outbreak in a Roma community.

Methods: We describe a community-wide outbreak of genotype D8 measles that took place in southeastern France, between May and July 2017, along with the control measures adopted.

Results: We identified a total of eighteen cases, between six months and 24 years old. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.08.023DOI Listing
November 2018
10 Reads

Multimodal safety assessment of measles-mumps-rubella vaccination after pediatric liver transplantation.

Am J Transplant 2018 Sep 1. Epub 2018 Sep 1.

Department of Pediatrics, Division of General Pediatrics, Children's Hospital, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

Live-attenuated vaccines are currently contraindicated in solid-organ transplant recipients. However, the risk of vaccine-preventable infections is lifelong, and can be particularly severe after transplantation. In this prospective interventional national cohort study, 44 pediatric liver transplant recipients with measles IgG antibodies <150 IU/L (below seroprotection threshold) received measles-mumps-rubella vaccine (MMR) at a median of 6. Read More

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http://dx.doi.org/10.1111/ajt.15101DOI Listing
September 2018
3 Reads

Dominant SCN2A Mutation Causes Familial Episodic Ataxia and Impairment of Speech Development.

Neuropediatrics 2018 Dec 30;49(6):379-384. Epub 2018 Aug 30.

Division of Pediatric Neurology, Department of Pediatrics, University Hospital Cologne, Cologne, Germany.

Mutations in are associated with a heterogeneous clinical spectrum including epilepsy and autism. Here, we have identified a peculiar phenotype associated with vaccination related exacerbations of ataxia. We report the first family with three individuals affected by -associated episodic ataxia (EA) with impaired speech development. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1668141
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http://dx.doi.org/10.1055/s-0038-1668141DOI Listing
December 2018
11 Reads

Seroprevalence of Maternal and Cord Antibodies Specific for Diphtheria, Tetanus, Pertussis, Measles, Mumps and Rubella in Shunyi, Beijing.

Sci Rep 2018 Aug 29;8(1):13021. Epub 2018 Aug 29.

Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Maternal antibodies contribute to the protection of young infants from infectious diseases during the early life. However, vaccinations for women of child-bearing age are not routine in China. Therefore, we investigated the level of protective immunity against vaccine preventable diseases in pregnant women and newborns in China. Read More

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http://dx.doi.org/10.1038/s41598-018-31283-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115429PMC
August 2018
7 Reads
5.080 Impact Factor

[Prevalence of maternal measles, rubella, mumps and varicella antibodies in the first six months of life].

Mikrobiyol Bul 2018 Jul;52(3):324-327

Istanbul University Faculty of Medicine, Department of Medical Microbiology, Division of Virology and Basic Immunology, Istanbul, Turkey.

The protection of infants against infections during the first few months of life is provided mainly by maternal antibodies. The presence of maternal antibodies can decrease vaccine efficacy. The waning time of maternal antibodies shows variations therefore seroepidemiological studies are important for the development of vaccination schedules. Read More

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http://www.mikrobiyolbul.org/linkout.aspx?pmid=30156519
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http://dx.doi.org/10.5578/mb.67169DOI Listing
July 2018
17 Reads

Update From the Advisory Committee on Immunization Practices.

J Pediatric Infect Dis Soc 2018 Dec;7(4):270-274

Department of Pediatrics, University of Alabama at Birmingham.

The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Read More

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http://dx.doi.org/10.1093/jpids/piy070DOI Listing
December 2018
1 Read

Recurrent invasive group A streptococcal infection with four-limb amputation in an immunocompetent child.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.

We report a previously well paediatric patient with two distinct presentations of invasive group A streptococcus (GAS) infection resulting in significant morbidity. The first episode, following GAS pharyngitis, involved multiorgan dysfunction syndrome. This included cardiorespiratory and acute hepatorenal failure and purpura fulminans that eventually necessitated four-limb amputation. Read More

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http://dx.doi.org/10.1136/bcr-2018-225292DOI Listing
July 2018
3 Reads

Pediatricians' vaccine attitudes and practices before and after a major measles outbreak.

J Child Health Care 2018 Jan 1:1367493518786011. Epub 2018 Jan 1.

3 Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA.

The objective of this study was to describe how a sample of pediatricians were impacted by and responded to the Disneyland measles outbreak in the United States. We conducted three repeated cross-sectional, online surveys in 2014 (before the outbreak), 2015, and 2016 (after the outbreak) among members of three state chapters of the American Academy of Pediatrics. We assessed pediatricians' level of willingness and length of time comfortable delaying the measles-mumps-rubella (MMR) vaccine before and after the outbreak. Read More

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http://dx.doi.org/10.1177/1367493518786011DOI Listing
January 2018
4 Reads

Immunization Mandates, Vaccination Coverage, and Exemption Rates in the United States.

Open Forum Infect Dis 2018 Jun 2;5(6):ofy130. Epub 2018 Jun 2.

Department of Family Medicine, SUNY Upstate Medical University, Syracuse, New York.

Background: Vaccination coverage among children entering kindergarten in the United States is high, but interstate variations exist. The relationship between state immunization laws and vaccination coverage has not been fully assessed. We evaluated associations of state laws on both measles, mumps, and rubella (MMR) and diphtheria, tetanus, and pertussis (DTaP) vaccination coverage and exemptions to school immunization requirements. Read More

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http://dx.doi.org/10.1093/ofid/ofy130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016709PMC
June 2018
26 Reads

Progress and challenges for the Japanese immunization program: Beyond the "vaccine gap".

Vaccine 2018 07 19;36(30):4582-4588. Epub 2018 Jun 19.

Kawasaki City Institute for Public Health, Kanagawa, Japan, 3-25-13 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821 Japan.

The Japanese immunization program has made considerable recent progress. The introduction of several new vaccines, especially foreign-produced vaccines, and the inclusion of important new vaccines in the National Immunization Program (NIP) are closing the "vaccine gap", i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X183082
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http://dx.doi.org/10.1016/j.vaccine.2018.01.092DOI Listing
July 2018
5 Reads

Mandatory vaccinations in European countries, undocumented information, false news and the impact on vaccination uptake: the position of the Italian pediatric society.

Ital J Pediatr 2018 Jun 14;44(1):67. Epub 2018 Jun 14.

Bambino Gesù Children Hospital, Pediatric and Infectious Diseases Unit, Rome, Italy.

Background: High rates of vaccination coverage are important in preventing infectious diseases. Enforcing mandatory vaccinations is one of the strategies that some Countries adopted to protect the community when vaccination coverage is not satisfactory. In Italy, in 2017 vaccination against diphtheria, tetanus, pertussis, hepatitis B, poliovirus, Haemophilus influenzae type b, measles, mumps, rubella and varicella became compulsory in childhood. Read More

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http://dx.doi.org/10.1186/s13052-018-0504-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001041PMC
June 2018
7 Reads

Vaccine-preventable diseases, vaccines and Guillain-Barre' syndrome.

Vaccine 2018 Jun 4. Epub 2018 Jun 4.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Perugia, Italy. Electronic address:

Guillain-Barré syndrome (GBS) is an acute, immune-mediated polyradiculoneuropathy. Infections and vaccines have been hypothesized to play a role in triggering GBS development. These beliefs can play a role in reducing vaccination coverage. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.05.119DOI Listing
June 2018
5 Reads

Pharyngolaryngeal edema in mumps virus infection: Rare complication.

Pediatr Int 2018 May;60(5):493-494

Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Niigata, Japan.

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http://dx.doi.org/10.1111/ped.13552DOI Listing
May 2018
1 Read

Update From the Advisory Committee on Immunization Practices.

J Pediatric Infect Dis Soc 2018 May;7(2):93-99

Stanford University School of Medicine, California.

The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, each of whom is appointed to a 4-year term. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Read More

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http://dx.doi.org/10.1093/jpids/piy028DOI Listing
May 2018
6 Reads

Mumps: A Pain in the Neck.

J Pediatric Infect Dis Soc 2018 May;7(2):91-92

Emeritus Professor of Pediatrics, University of Pennsylvania, Vaxconsult, Doylestown, Pennsylvania.

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http://dx.doi.org/10.1093/jpids/piy038DOI Listing
May 2018
1 Read

Mumps outbreaks: A problem in need of solutions.

J Infect 2018 Jun 18;76(6):503-506. Epub 2018 Apr 18.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Perugia, Italy. Electronic address:

Objectives: To discuss what is presently known about recent mumps outbreaks and what solutions can be suggested to ensure more complete protection against mumps.

Methods: PubMed was used to search for all of the studies published over the last 15 years using the key words "mumps" or "mumps virus" or "mumps vaccine". More than 1500 articles were found, but only those published in English or providing evidence-based data were included in the evaluation. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.03.002DOI Listing
June 2018
5 Reads

Acute Motor Axonal Polyneuropathy Following Mumps Infection in a 9-Year-Old Girl.

J Trop Pediatr 2019 Feb;65(1):98-100

Department of Paediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

A 9-year-old girl presented with lower motor neuron type of paralysis involving limbs, trunk and multiple cranial nerves (7, 9 and 10) with preceding history of mumps 1 week before the onset of weakness. There were no features to suggest either a meningitis or encephalitis in the child. Cerebrospinal fluid showed hypoglycorrhachia and mild protein elevation; magnetic resonance imaging of the brain was normal. Read More

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http://dx.doi.org/10.1093/tropej/fmy018DOI Listing
February 2019
4 Reads

The immunization status of children with chronic neurological disease and serological assessment of vaccine-preventable diseases.

Hum Vaccin Immunother 2018 14;14(8):1970-1976. Epub 2018 May 14.

d Eskisehir Osmangazi University Faculty of Medicine , Department of Pediatric Intensive Care Unit , Eskisehir , Turkey.

The aim of this study was to evaluate the age-appropriate immunization coverage in 366 children with chronic neurological disease (CND), to evaluate the use of vaccines not included in routine program, to evaluate serological tests for vaccine-preventable diseases and to describe the related factors in unvaccinated children. 95.6% of all children with had received age-appropriate vaccinations according to the actual National Immunization Program (NIP) during childhood. Read More

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http://dx.doi.org/10.1080/21645515.2018.1460986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149706PMC
May 2018
6 Reads

How often do children receive their vaccinations late, and why?

Saudi Med J 2018 Apr;39(4):347-353

Department of Pediatrics, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia. E-mail.

Objectives: To assess vaccination timeliness, risk factors associated with delays and the reasons for delayed vaccinations among children below the age of 3 years in Jeddah, Kingdom of Saudi Arabia.

Methods: This is a cross-sectional study conducted in Jeddah, Saudi Arabia during the period of May 2016 to August 2017. Data were obtained from parents of children under the age of 3 years using a structured questionnaire comprised of questions about sociodemographics, physical well-being of the child and the reasons that are used to justify delayed vaccinations. Read More

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http://dx.doi.org/10.15537/smj.2018.4.21473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938647PMC
April 2018
4 Reads

A phase III, open-label, randomised multicentre study to evaluate the immunogenicity and safety of a booster dose of two different reduced antigen diphtheria-tetanus-acellular pertussis-polio vaccines, when co-administered with measles-mumps-rubella vaccine in 3 and 4-year-old healthy children in the UK.

Vaccine 2018 04 22;36(17):2300-2306. Epub 2018 Mar 22.

Bristol Children's Vaccine Centre, University of Bristol, Upper Maudlin Street, Bristol BS2 8AE, UK.

Aim: To evaluate the immunogenicity and safety of a reduced antigen diphtheria-tetanus-acellular pertussis-inactivated poliovirus (dTap-IPV) vaccine (Boostrix-IPV, GSK) as a pre-school booster in 3-4 year old children as compared to dTap-IPV (Repevax, Sanofi Pasteur), when co-administered with mumps-measles-rubella vaccine (MMRV).

Methods: This phase III, open label, randomised study was conducted in the UK between April 2011 and April 2012. Children due their pre-school dTap-IPV booster vaccination were randomised 2:1 to receive one of two different dTap-IPV vaccines (dTap-IPV or dTap-IPV) with blood sample for immunogenicity assessment just prior and one month after vaccination. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.03.021DOI Listing
April 2018
6 Reads

Prevalence and risk factors of measles seronegativity in a cohort of HIV-positive subjects: a retrospective study.

HIV Med 2018 07 24;19(6):426-429. Epub 2018 Mar 24.

Infectious Diseases Department, CHU Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium.

Objectives: Measles infection is a vaccine-preventable disease currently resurging in Europe. HIV-infected subjects are at higher risk of complications following measles infection. We investigated the risk factors associated with being seronegative in a cohort of HIV-infected subjects. Read More

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http://dx.doi.org/10.1111/hiv.12610DOI Listing
July 2018
2 Reads

Imported case of measles in a university setting leading to an outbreak of measles in Edinburgh, Scotland from September to December 2016.

Epidemiol Infect 2018 04 22;146(6):741-746. Epub 2018 Mar 22.

National Health Service,Lothian,Directorate of Public Health and Health Policy,Edinburgh,UK.

In September 2016, an imported case of measles in Edinburgh in a university student resulted in a further 17 confirmed cases during October and November 2016. All cases were genotype D8 and were associated with a virus strain most commonly seen in South East Asia. Twelve of the 18 cases were staff or students at a university in Edinburgh and 17 cases had incomplete or unknown measles mumps rubella (MMR) vaccination status. Read More

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http://dx.doi.org/10.1017/S0950268818000602DOI Listing
April 2018
8 Reads

Prospective Study of Live Attenuated Vaccines for Patients with Nephrotic Syndrome Receiving Immunosuppressive Agents.

J Pediatr 2018 05 28;196:217-222.e1. Epub 2018 Feb 28.

Department of Pediatrics, Yokohama City University, Yokohama, Japan.

Objective: To conduct a prospective study to evaluate the immunogenicity and safety of live attenuated vaccines in patients with nephrotic syndrome receiving immunosuppressive agents.

Study Design: Patients with nephrotic syndrome receiving immunosuppressive agents with negative or borderline antibody titers (virus-specific IgG levels <4.0) against measles, rubella, varicella, and/or mumps fulfilling the criteria of cellular and humoral immunity were enrolled. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223476173175
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http://dx.doi.org/10.1016/j.jpeds.2017.12.061DOI Listing
May 2018
9 Reads

Methods for addressing "innocent bystanders" when evaluating safety of concomitant vaccines.

Pharmacoepidemiol Drug Saf 2018 Apr 13;27(4):405-412. Epub 2018 Feb 13.

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital; Department of Medicine, Harvard Medical School, Boston, MA, USA.

Purpose: The need to develop methods for studying the safety of childhood immunization schedules has been recognized by the Institute of Medicine and Department of Health and Human Services. The recommended childhood immunization schedule includes multiple vaccines in a visit. A key concern is safety of concomitant (same day) versus separate day vaccination. Read More

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http://dx.doi.org/10.1002/pds.4399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937260PMC
April 2018
8 Reads

Long-term Seroprotection Rates Following Second Dose of Measles as MMR Vaccine at 15 months in Indian Children.

Indian Pediatr 2018 May 9;55(5):405-407. Epub 2018 Feb 9.

Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Objective: To find out seropositivity rates at 4-6 and 9-12 years of age; among those who received one-dose measles at 9 months and one-dose MMR at 15 months of age.

Methods: 80 healthy children (53 males) at 4-6 or 9-12 years of age, attending outpatient department for vaccination were enrolled. Antibody titers were estimated using commercially available quantitative-IgG ELISA kits. Read More

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May 2018
7 Reads
1.010 Impact Factor

Safety and immunogenicity of a meningococcal B recombinant vaccine when administered with routine vaccines to healthy infants in Taiwan: A phase 3, open-label, randomized study.

Hum Vaccin Immunother 2018 05 15;14(5):1075-1083. Epub 2018 Feb 15.

f Research and Development Center, GSK , Siena , Italy.

Neisseria meningitidis is associated with high mortality and morbidity in infants and children worldwide. This phase 3 study (NCT02173704) evaluated safety and immunogenicity of a 4-component serogroup B recombinant meningococcal vaccine (4CMenB) co-administered with routine vaccines in Taiwanese infants. In total, 225 healthy infants were randomized (2 : 1 ) to receive 4CMenB and routine vaccines (4CMenB+Routine) or routine vaccines only (Routine group) at 2, 4, 6 and 12 months of age. Read More

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http://dx.doi.org/10.1080/21645515.2018.1425659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989895PMC
May 2018
25 Reads

Vaccination titres pre- and post-transplant in paediatric renal transplant recipients and the impact of immunosuppressive therapy.

Pediatr Nephrol 2018 May 10;33(5):897-910. Epub 2018 Jan 10.

Department of Paediatrics I, University Children's Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.

Background: Avoidance of vaccine-preventable infections in paediatric renal allograft recipients is of utmost importance. However, the development and maintenance of protective vaccination titres may be impaired in this patient population owing to their need for immunosuppressive medication.

Methods: In the framework of the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN), we therefore performed a multi-centre, multi-national study and analysed vaccination titres pre- and post-transplant in 155 patients with serial titre measurements in comparison with published data in healthy children. Read More

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http://dx.doi.org/10.1007/s00467-017-3868-0DOI Listing
May 2018
24 Reads

Campaign Mode MMR Vaccination to Control Outbreak of Mumps in a Highly Vaccinated Population: Evidence-based Medicine viewpoint.

Authors:
Joseph L Mathew

Indian Pediatr 2017 12;54(12):1047-1049

Department of Pediatrics, PGIMER, Chandigarh, India.

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December 2017
7 Reads

Questionnaire survey on mumps vaccination for parents in Nara prefecture, Japan.

Pediatr Int 2018 Apr 26;60(4):362-365. Epub 2018 Feb 26.

Department of Pediatrics, Nara Prefecture General Medical Center, Nara, Japan.

Background: Although the mumps vaccine has not been included in the national immunization program (NIP) in Japan, it has been shown that a two-dose routine vaccine program would be highly cost-effective. In this study, we carried outa questionnaire-based study to investigate how many Japanese parents want the mumps vaccine to be included in the NIP with proper information.

Methods: The questionnaire was given to parents who visited the Pediatrics or neonatal intensive care unit of Nara Prefecture General Medical Center, Nara City, Japan, between 1 March 2017 and 31 August 2017. Read More

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http://dx.doi.org/10.1111/ped.13502DOI Listing
April 2018
5 Reads

Immunization Practices of U.S. Obstetrician/Gynecologists for Pregnant Patients.

Am J Prev Med 2018 02 13;54(2):205-213. Epub 2017 Dec 13.

Adult and Child Consortium for Health Outcomes Research and Delivery Science, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Introduction: U.S. obstetrician/gynecologists play a critical role as vaccinators of pregnant women. Read More

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http://dx.doi.org/10.1016/j.amepre.2017.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783738PMC
February 2018
10 Reads

Vaccination Practices in Pediatric Dialysis Patients Across Europe. A European Pediatric Dialysis Working Group and European Society for Pediatric Nephrology Dialysis Working Group Study.

Nephron 2018 12;138(4):280-286. Epub 2017 Dec 12.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Data on the immunization practices in pediatric chronic kidney disease (CKD) patients are scarce. The purpose of this study was to evaluate current vaccination practices for children on dialysis across European pediatric nephrology centers.

Methods: A total of 18 tertiary pediatric nephrology centers from 12 European countries were included in the study. Read More

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http://dx.doi.org/10.1159/000485398DOI Listing
December 2017
48 Reads

Asymmetric Oligoarthritis With Enthesitis Associated With Acute Mumps Virus Infection.

Pediatr Infect Dis J 2018 01;37(1):112

Department of Pediatrics, Japanese Red Cross Wakayama Medical Centerm, Wakayama, Japan.

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http://dx.doi.org/10.1097/INF.0000000000001717DOI Listing
January 2018
3 Reads

One or two doses of live varicella virus-containing vaccines: Efficacy, persistence of immune responses, and safety six years after administration in healthy children during their second year of life.

Vaccine 2018 01 7;36(3):381-387. Epub 2017 Dec 7.

Vaccine Discovery and Development, GSK, Philadelphia, United States. Electronic address:

Background: This phase III B follow-up of an initial multicenter study (NCT00226499) will evaluate the ten-year efficacy of two doses of the combined measles-mumps-rubella-varicella vaccine (MMRV) and one dose of the live attenuated varicella vaccine (V) versus a measles-mumps-rubella control group (MMR) for the prevention of clinical varicella disease. Here we present efficacy results for six years post-vaccination.

Methods: In phase A of the study, healthy children aged 12-22 months from ten European countries were randomized (3:3:1) and received either two doses of MMRV, or one dose of combined MMR and one dose of monovalent varicella vaccine (MMR+V), or two doses of the MMR vaccine (control), 42 days apart. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X173172
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http://dx.doi.org/10.1016/j.vaccine.2017.11.081DOI Listing
January 2018
19 Reads

Diagnostic Approach to Viral Acute Encephalitis Syndrome (AES) in Paediatric Age Group: A Study from New Delhi.

J Clin Diagn Res 2017 Sep 1;11(9):DC25-DC29. Epub 2017 Sep 1.

Phd Student, Department of Microbiology, Maulana Azad Medical College, New Delhi, New Delhi, India.

Introduction: Acute Encephalitis Syndrome has heralded the emergence of multiple virulent pathogens, which may result in severe morbidity and mortality. In India, encephalitis is not notified and there has been a dearth of analysis for trends in encephalitis death rates and causation. A downward trend has been observed in encephalitis deaths, due to 'known' causes, which can be largely explained by improvement in diagnostic, treatment, and prevention methods. Read More

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http://dx.doi.org/10.7860/JCDR/2017/27413.10648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713729PMC
September 2017
14 Reads

Early impact of universal varicella vaccination on childhood varicella and herpes zoster hospitalizations in Brazil.

Vaccine 2018 01 1;36(2):280-284. Epub 2017 Dec 1.

Centro Infant, Department of Pediatrics, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga 6690, 2nd floor, ZIP-Code: 90610-000, Porto Alegre, Rio Grande do Sul State, Brazil. Electronic address:

Introduction: The Brazilian childhood National Immunization Program (NIP) introduced live and attenuated varicella vaccination in a single dose, combined as tetraviral vaccine, at 15 months of age in the whole country, during September to December of 2013. The aim of this study was to report trends in incidence of childhood hospital admissions related to varicella and zoster in Brazil from 2003 to 2016, including the first three years after vaccine introduction.

Methods: The number and incidence of hospital admission in patients aged less than 20 years in Brazilian public health system with an admission diagnosis of varicella and zoster from 2003 to 2016 were analyzed and pre (2003-2013) and post-vaccination periods (2014-2016) were compared. Read More

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http://dx.doi.org/10.1016/j.vaccine.2017.11.057DOI Listing
January 2018
41 Reads