617 results match your criteria Pediatrics Meningitis and Encephalitis


Metagenomic Next-Generation Sequencing for Pathogen Detection and Transcriptomic Analysis in Pediatric Central Nervous System Infections.

Open Forum Infect Dis 2021 Jun 6;8(6):ofab104. Epub 2021 Mar 6.

Rady Children's Institute for Genomic Medicine, San Diego, California, USA.

Background: Pediatric central nervous system (CNS) infections are potentially life-threatening and may incur significant morbidity. Identifying a pathogen is important, both in terms of guiding therapeutic management and in characterizing prognosis. Usual care testing by culture and polymerase chain reaction is often unable to identify a pathogen. Read More

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Assessment of the FilmArray ME panel in 4199 consecutively tested cerebrospinal fluid samples.

Clin Microbiol Infect 2021 May 17. Epub 2021 May 17.

Region Västra Götaland, Sahlgrenska University Hospital, Department of Infectious Diseases, Gothenburg, Sweden; Institute of Biomedicine, Department of Infectious Diseases, University of Gothenburg, Gothenburg, Sweden.

Objectives: In central nervous system infections, early and correct management is of utmost importance. Rapid syndromic panel testing can potentially provide valuable guidance. The FilmArray meningitis/encephalitis (ME) panel detects 14 pathogens through multiplex PCR. Read More

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Varicella zoster virus infection in neurological patients in Bulgaria.

J Neurovirol 2021 04 4;27(2):272-278. Epub 2021 Mar 4.

Infectious Diseases Unit, General Hospital, Pazardjik, Bulgaria.

The clinical manifestations of neurological complications associated with varicella zoster virus (VZV) are non-specific and indistinguishable from those of other viral infections. Therefore, the definite diagnosis requires evidence of VZV infection in cerebrospinal fluid (CSF). The aim of this study was to determine the frequency of VZV DNA detection in CSF of patients with neurological diseases in order to obtain information concerning involvement of VZV infection in neuropathology in the country. Read More

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Outbreak of Enterovirus Infection with Neurological Presentations in a Pediatric Population in Northern Spain: A Clinical Observational Study.

Neuropediatrics 2021 06 3;52(3):192-200. Epub 2021 Mar 3.

Paediatric Neurology Unit, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.

Objective: The study aimed to describe the cases of neurological disease related to the outbreak of enterovirus (EV) in three regions in Northern Spain during 2016.

Materials And Methods: Multicenter retrospective observational study. Clinical, radiological, and microbiological data were analyzed from patients younger than 15 years with confirmed EV-associated neurological disease admitted to 10 hospitals of Asturias, Cantabria, and Castile and Leon between January 1 and December 31, 2016. Read More

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Clinical features of SARS-CoV-2-associated encephalitis and meningitis amid COVID-19 pandemic.

World J Clin Cases 2021 Feb;9(5):1058-1078

Department of Pediatric Neurology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.

Background: Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic, numerous studies have been published on SARS-CoV-2-related encephalitis/meningitis, but it has not been established if there are specific clinical characteristics of encephalitis/meningitis associated with SARS-CoV-2 infection.

Aim: To identify the specific clinical features of cases of encephalitis/meningitis associated with SARS-CoV-2 infection in the context of this virus infection pandemic and investigate their relationship with SARS-CoV-2 infection.

Methods: We searched PubMed, and included single case reports and case series with full text in English, reporting original data of coronavirus disease-19 (COVID-19) patients with encephalitis/meningitis and a confirmed recent SARS-CoV-2 infection. Read More

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February 2021

Acute Meningoencephalitis in a Child Secondary to SARS-CoV-2 Virus.

Authors:
Mukul Pandey

Indian Pediatr 2021 02;58(2):183-184

Department of Pediatrics, St Stephens Hospital, Delhi, India.

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February 2021

Meningoencephalitis Associated with SARS-CoV-2 Infection.

Indian J Pediatr 2021 05 24;88(5):490. Epub 2021 Feb 24.

Department of Pediatrics, Karnataka Institute of Medical Sciences, Hubli, 580021, Karnataka, India.

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MRI Spectrum of Meningoencephalitis in Children.

Ann Indian Acad Neurol 2020 Sep-Oct;23(5):616-620. Epub 2019 Dec 24.

Department of Pediatrics, Medanta, The Medicity, Gurugram, NCR, Haryana, India.

Background And Purpose: type b (Hib) infection occurs mostly in children and is transmitted from person to person through the respiratory pathway. Hib strain is associated with meningitis or encephalitis. It is not an uncommon infection, particularly, in the developing world. Read More

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December 2019

Frequency Distribution of Antibiotic Therapy Intervention According to Lumbar Puncture Cerebrospinal Fluid Outcome in Hospitalized Children.

Maedica (Bucur) 2020 Dec;15(4):454-460

Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

The aim of this study was to evaluate the frequency distribution of antibiotic therapy according to lumbar puncture outcome in hospitalized children. This study was conducted on 94 children undergoing lumbar puncture. All data were extracted from medical records. Read More

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December 2020

REACTIVATION VARICELLA ZOSTER MENINGOENCEPHALITIS AND SINUSITIS IN A SEEMINGLY IMMUNOCOMPETENT ADOLESCENT.

J Paediatr Child Health 2021 02;57(2):307

Department of General Paediatrics, Monash Children's Hospital, Clayton, Victoria, Australia.

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February 2021

Clinical and Genetic Profile of X-Linked Agammaglobulinemia: A Multicenter Experience From India.

Front Immunol 2020 15;11:612323. Epub 2021 Jan 15.

Department of Pediatric Hematology Oncology and Bone Marrow Transplant, Kanchi Kamakoti Childs Trust Hospital, Chennai, India.

Background: There is paucity of literature on XLA from developing countries. Herein we report the clinical and molecular profile and outcome in a multicenter cohort of patients with XLA from India.

Methods: Data on XLA from all regional centers supported by the Foundation for Primary Immunodeficiency Diseases (FPID), USA and other institutions providing care to patients with PIDs were collated. Read More

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January 2021

Bulging fontanel during a measles infection.

Germs 2020 Dec 28;10(4):385-387. Epub 2020 Dec 28.

MD, Yildirim Beyazit University, Faculty of Medicine, Department of General Pediatrics, Ankara City Hospital, Children's Hospital, Üniversiteler Mahallesi 1604., Cadde no: 9, Çankaya, Ankara, Turkey.

Introduction: Introduction Causes of a bulging fontanel in children include viral/bacterial meningitis, encephalitis, hydrocephaly, intracranial bleeding, psedotumor cerebri and central nervous system tumors. A less well-known cause of acutely-developing fontanel bulging is transient intracranial hypertension.

Case Report: A 7-month-old female was brought to our hospital with fever, cough, watery nasal secretion and bulging fontanel for the last 3 days. Read More

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December 2020

Molecular Epidemiology of Enterovirus in Children with Central Nervous System Infections.

Viruses 2021 Jan 13;13(1). Epub 2021 Jan 13.

First Department of Pediatrics, Infectious Diseases and Chemotherapy Research Laboratory, Medical School, National and Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, 11526 Athens, Greece.

Limited recent molecular epidemiology data are available for pediatric Central Nervous System (CNS) infections in Europe. The aim of this study was to investigate the molecular epidemiology of enterovirus (EV) involved in CNS infections in children. Cerebrospinal fluid (CSF) from children (0-16 years) with suspected meningitis-encephalitis (ME) who were hospitalized in the largest pediatric hospital of Greece from October 2017 to September 2020 was initially tested for 14 common pathogens using the multiplex PCR FilmArray ME Panel (FA-ME). Read More

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January 2021

Neurodevelopmental Outcome in Neonates with Acinetobacter Sepsis with Meningitis and/or Ventriculitis at 2-5 years.

Indian J Pediatr 2021 04 7;88(4):400-401. Epub 2021 Jan 7.

Department of Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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Measuring complications of serious pediatric emergencies using ICD-10.

Health Serv Res 2021 Apr 29;56(2):225-234. Epub 2020 Dec 29.

Division of General Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA.

Objective: To create definitions for complications for 16 serious pediatric conditions using the International Classification of Diseases, 10th Revision, Clinical Modification or Procedure Coding System (ICD-10-CM/PCS), and to assess whether complication rates are similar to those measured with ICD-9-CM/PCS.

Data Sources: The Healthcare Cost and Utilization Project State Emergency Department and Inpatient Databases from five states between 2014 and 2017 were used to identify cases and assess complication rates. Incidences were calculated using population counts from the 5-year American Community Survey. Read More

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Acute Meningoencephalitis in a Child Secondary to SARS-CoV-2 Virus.

Authors:
Mukul Pandey

Indian Pediatr 2021 02 19;58(2):183-184. Epub 2020 Dec 19.

Department of Pediatrics, St Stephens Hospital, Delhi, India.

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February 2021

Next-generation Sequencing of Cerebrospinal Fluid for the Diagnosis of Unexplained Central Nervous System Infections.

Pediatr Neurol 2021 02 30;115:10-20. Epub 2020 Oct 30.

Department of Pediatrics, The First Hospital of Jilin University, Changchun, Jilin, PR China. Electronic address:

Background: Central nervous system infections cause substantial morbidity and mortality in pediatric patients. However, in approximately half of the clinical cases, the etiology is unidentified. As an unbiased molecular diagnostic technology, next-generation sequencing is gradually being applied to investigate central nervous system infections. Read More

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February 2021

Clinical features and outcomes of nonconvulsive status epilepticus in a developing country: A 5-year retrospective study.

Epilepsy Behav 2020 12 24;113:107547. Epub 2020 Nov 24.

Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Electroencephalography Unit, Department of Neurosciences, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.

Background: This study aimed to determine the frequency of electrographically confirmed nonconvulsive status epilepticus (NCSE) in a cohort suspected with this condition and to determine the demographic/clinical profile, treatment, and outcomes of these patients in the context of a developing country, the Philippines.

Methods: We conducted a retrospective study among patients with suspected with NCSE admitted in the Philippine General Hospital from 2014 to 2019. Using the Salzberg 2013 criteria to diagnose NCSE, three electroencephalographers independently reviewed the electroencephalogram (EEG) tracings of suspected patients and were blinded from the clinical information. Read More

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December 2020

Clinical characteristics of Epstein-Barr virus infection in the pediatric nervous system.

BMC Infect Dis 2020 Nov 25;20(1):886. Epub 2020 Nov 25.

Department of Neurology, Children's Hospital of Chongqing Medical University, No.136 Zhongshan 2nd Road, Yu Zhong District, Chongqing, 400014, China.

Background: To investigate the clinical characteristics of Epstein-Barr virus (EBV) infection in the pediatric nervous system (NS).

Methods: We retrospectively analyzed the clinical data and follow-up results of 89 children with neurological damage caused by EBV who were hospitalized in the children's hospital of Chongqing Medical University from January 2008 to April 2019.

Results: EBV infection of the NS can occur at any time of the year. Read More

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November 2020

Neurologic Emergencies at the Extremes of Age.

Emerg Med Clin North Am 2021 Feb;39(1):47-65

Department of Emergency Medicine, University of Maryland School of Medicine, 110 S Paca St, 6th Floor, Suite 200, Baltimore, MD 21201, USA; Maryland Emergency Medicine Network, Upper Chesapeake Emergency Medicine, 500 Upper Chesapeake Drive, Bel Air, MD 21014, USA.

The diagnosis and management of neurologic conditions are more complex at the extremes of age than in the average adult. In the pediatric population, neurologic emergencies are somewhat rare and some may require emergent consultation. In older adults, geriatric physiologic changes with increased comorbidities leads to atypical presentations and worsened outcomes. Read More

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February 2021

Impact of a Rapid Diagnostic Meningitis/Encephalitis Panel on Antimicrobial Use and Clinical Outcomes in Children.

Antibiotics (Basel) 2020 Nov 18;9(11). Epub 2020 Nov 18.

Department of Pediatrics, Goryeb Children's Hospital, Atlantic Health System, Morristown, NJ 07960, USA.

Rapid molecular diagnostic assays are increasingly used to guide effective antimicrobial therapy. Data on their effectiveness to decrease antimicrobial use in children have been limited and varied. We aimed to assess the impact of the implementation of the FilmArray Meningitis Encephalitis Panel (MEP) on antimicrobial use and outcomes in children. Read More

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November 2020

Cerebrospinal Fluid Analysis for Viruses by Metagenomic Next-Generation Sequencing in Pediatric Encephalitis: Not Yet Ready for Prime Time?

J Child Neurol 2021 Apr 18;36(5):350-356. Epub 2020 Nov 18.

Division of Infectious Diseases, Department of Pediatrics, 2650Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA.

Background: Metagenomic next-generation sequencing offers an unbiased approach to identifying viral pathogens in cerebrospinal fluid of patients with meningoencephalitis of unknown etiology.

Methods: In an 11-month case series, we investigated the use of cerebrospinal fluid metagenomic next-generation sequencing to diagnose viral infections among pediatric hospitalized patients presenting with encephalitis or meningoencephalitis of unknown etiology. Cerebrospinal fluid from patients with known enterovirus meningitis were included as positive controls. Read More

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A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures.

Ann Neurol 2021 02 3;89(2):327-340. Epub 2020 Dec 3.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Objective: In the absence of controlled trials, treatment of neonatal seizures has changed minimally despite poor drug efficacy. We tested bumetanide added to phenobarbital to treat neonatal seizures in the first trial to include a standard-therapy control group.

Methods: A randomized, double-blind, dose-escalation design was employed. Read More

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February 2021

Point-of-Care Approaches for Meningitis Diagnosis in a Low-Resource Setting (Southwestern Uganda): Observational Cohort Study Protocol of the "PI-POC" Trial.

JMIR Res Protoc 2020 Nov 4;9(11):e21430. Epub 2020 Nov 4.

Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.

Background: A timely differential diagnostic is essential to identify the etiology of central nervous system (CNS) infections in children, in order to facilitate targeted treatment, manage patients, and improve clinical outcome.

Objective: The Pediatric Infection-Point-of-Care (PI-POC) trial is investigating novel methods to improve and strengthen the differential diagnostics of suspected childhood CNS infections in low-income health systems such as those in Southwestern Uganda. This will be achieved by evaluating (1) a novel DNA-based diagnostic assay for CNS infections, (2) a commercially available multiplex PCR-based meningitis/encephalitis (ME) panel for clinical use in a facility-limited laboratory setting, (3) proteomics profiling of blood from children with severe CNS infection as compared to outpatient controls with fever yet not severely ill, and (4) Myxovirus resistance protein A (MxA) as a biomarker in blood for viral CNS infection. Read More

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November 2020

Burden of Neurological Disorders Across the US From 1990-2017: A Global Burden of Disease Study.

JAMA Neurol 2021 Feb;78(2):165-176

Department of Systems, Populations, and Leadership, University of Michigan, Ann Arbor.

Importance: Accurate and up-to-date estimates on incidence, prevalence, mortality, and disability-adjusted life-years (burden) of neurological disorders are the backbone of evidence-based health care planning and resource allocation for these disorders. It appears that no such estimates have been reported at the state level for the US.

Objective: To present burden estimates of major neurological disorders in the US states by age and sex from 1990 to 2017. Read More

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February 2021

Cerebrospinal fluid neopterin as a biomarker of neuroinflammatory diseases.

Sci Rep 2020 10 26;10(1):18291. Epub 2020 Oct 26.

Institut de Recerca Sant Joan de Déu, Barcelona, Spain.

The elevation of neopterin in cerebrospinal fluid (CSF) has been reported in several neuroinflammatory disorders. However, it is not expected that neopterin alone can discriminate among different neuroinflammatory etiologies. We conducted an observational retrospective and case-control study to analyze the CSF biomarkers neopterin, total proteins, and leukocytes in a large cohort of pediatric patients with neuroinflammatory disorders. Read More

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October 2020

Risks of severe hyponatremia in children receiving hypotonic fluids.

Arch Pediatr 2020 Nov 4;27(8):474-479. Epub 2020 Oct 4.

Service de pédiatrie générale, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

Intravenous fluids are frequently used in hospitalized children. Hypotonic fluids have been the standard of care in pediatrics for many years. This might be explained by the empiricism of early recommendations favoring fluids with dextrose, but an insufficient amount of sodium. Read More

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November 2020

A Rare Presentation of Neurobrucellosis in a 6-Year-Old Pediatric Patient with Sagittal Sinus Thrombosis.

Neuropediatrics 2021 02 5;52(1):48-51. Epub 2020 Oct 5.

Department of Pediatric Critical Care Medicine, Bezmialem Vakif University, Istanbul, Turkey.

Brucellosis is one of the most common zoonosis worldwide. It is still endemic in many regions of the world. A 6-year-old female was admitted to the emergency department (ED) due to a sudden change in consciousness, urinary incontinence, vomiting, and difficulty in walking. Read More

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February 2021

Burden of Pediatric Central Nervous System Infection and Cost-Benefit Simulation of Multiplex Polymerase Chain Reaction in Japan.

Jpn J Infect Dis 2021 Mar 30;74(2):144-147. Epub 2020 Sep 30.

Department of Pediatrics, Nara Prefecture General Medical Center, Japan.

To investigate the clinical use of multiplex polymerase chain reaction (mPCR) in Japan, epidemiological and clinical data for central nervous infections are needed. Here, we report on the epidemiology and economic burden of central nervous system infections and a simulation of the cost-benefit analysis of the Filmarray® Meningitis/Encephalitis (FAME) test for possible clinical use in Japan. We performed FAME tests on samples from 27 patients with pleocytosis aged between 0 and 20 years seen in six community hospitals in Nara and Osaka prefectures. Read More

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Acute Meningoencephalitis as Initial Presentation of SARS-CoV-2 Infection in Pediatrics.

Pediatr Infect Dis J 2020 11;39(11):e386-e387

Department of Pediatrics, Universidad de Antioquia, Medellín, Colombia.

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November 2020