519 results match your criteria Pediatrics Meningitis and Encephalitis


The role of CNS macrophages in streptococcal meningoencephalitis.

J Leukoc Biol 2019 Feb 14. Epub 2019 Feb 14.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany.

In the healthy brain, microglia and other CNS macrophages are the most abundant immune cell type. Thus, they form the natural immune cell interface with streptococci, which are the leading cause of bacterial meningitis and encephalitis in infants and young children. In homeostasis, the blood-brain barrier allows for very limited access of immune cells circulating in the periphery. Read More

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http://dx.doi.org/10.1002/JLB.4MR1118-419RDOI Listing
February 2019
1 Read

Human Herpes Virus 6 Positivity on the FilmArray Meningitis/Encephalitis Needs Clinical Interpretation.

Clin Infect Dis 2019 Jan 28. Epub 2019 Jan 28.

Department of Pediatrics, Section of Infectious Diseases, Lehigh Valley Children's Hospital, Allentown, Pennsylvania.

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http://dx.doi.org/10.1093/cid/ciz058DOI Listing
January 2019
1 Read

Neuropsychiatric symptoms following sore throat in a young boy.

BMJ Case Rep 2019 Jan 22;12(1). Epub 2019 Jan 22.

Department of Pediatrics, Jawaharlal Nehru Medical College, Aligarh, Uttar Pradesh, India.

A previously healthy 6-year-old boy was referred to us by his primary provider, with a history of sudden onset behavioural abnormalities including irritability, sleep disturbance and anxiety. Physical examination revealed no significant findings; further analyses were not suggestive of meningitis, encephalitis, metabolic abnormalities, toxicity or any other obvious cause. On rechecking the patient's history, an episode of throat pain 1 week prior to the symptom onset was noted. Read More

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http://dx.doi.org/10.1136/bcr-2018-227540DOI Listing
January 2019
2 Reads

Pediatric West Nile Virus-Associated Neuroinvasive Disease: A Review of the Literature.

Pediatr Neurol 2018 Nov 28. Epub 2018 Nov 28.

Section of Child Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas.

Over the past two decades, West Nile virus has become the most common arbovirus in North America, leading to several outbreaks and infecting thousands of people. Mosquitos help transmit the virus in the majority of cases, but transmission occurs via blood transfusions, organ transplantation, and possibly pregnancy and breastfeeding. While most infected patients experience mild to no symptoms, thousands of West Nile virus-associated neuroinvasive cases have been reported in the United States, with over 700 cases occurring in children from 2003 to 2016. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.07.019DOI Listing
November 2018
1 Read

Epidemiology of Meningitis and Encephalitis in Infants and Children in the United States, 2011-2014.

Pediatr Infect Dis J 2019 Jan;38(1):37-41

bioMérieux, Durham, NC.

Background: Large epidemiologic studies evaluating the etiologies, management decisions and outcomes of infants and children with meningitis and encephalitis in the United States are lacking.

Methods: Children 0-17 years of age with meningitis or encephalitis as assessed by International Classification of Diseases, Ninth Revision, codes available in the Premier Healthcare Database during 2011-2014 were analyzed.

Results: Six thousand six hundred sixty-five patients with meningitis or encephalitis were identified; 3030 (45. Read More

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http://dx.doi.org/10.1097/INF.0000000000002081DOI Listing
January 2019
9 Reads

Posterior Reversible Encephalopathy Syndrome in a Patient with Variegate Porphyria: A Case Report.

Cureus 2018 Sep 24;10(9):e3351. Epub 2018 Sep 24.

Orthopaedics, Dow University of Health Sciences, Karachi, PAK.

Variegate porphyria (VP) is one of the groups of rare inherited disorders of hemoglobin synthesis called Porphyria. It has two distinct manifestations, that is, those of cutaneous and nervous system. Posterior reversible encephalopathy syndrome (PRES) is a rare complication of porphyria. Read More

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http://dx.doi.org/10.7759/cureus.3351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255715PMC
September 2018
1 Read

Tick-borne encephalitis: A 43-year summary of epidemiological and clinical data from Latvia (1973 to 2016).

PLoS One 2018 13;13(11):e0204844. Epub 2018 Nov 13.

Pfizer Vaccines, Medical and Scientific Affairs, Paris, France and Vienna, Austria.

Background: The incidence of tick-borne encephalitis (TBE) varies significantly over time. To better understand the annual incidence of all TBE cases in Latvia we investigated the disease burden in the country from 1973-2016 using several available sources and case definitions.

Methods: We identified cases of TBE from an electronic database (maintained by the Centre for Disease Prevention and Control of Latvia [CDPC]) by the use of ICD-10 diagnosis codes for TBE (A84; A84. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204844PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233910PMC
November 2018
9 Reads

Letter to the editor: economic analysis lacks external validity to support universal syndromic testing for suspected meningitis/encephalitis.

Future Microbiol 2018 11 13;13:1553-1554. Epub 2018 Nov 13.

University of Colorado/Children's Hospital Colorado Department of Pediatrics, Section of Infectious Diseases & Epidemiology. Aurora, CO, 80045, USA.

In Response to: Duff S, et al. "Economic analysis of rapid multiplex polymerase chain reaction testing for meningitis/encephalitis in pediatric patients" Future Microbiology (2018) (Epub ahead of print). Read More

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https://www.futuremedicine.com/doi/10.2217/fmb-2018-0174
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http://dx.doi.org/10.2217/fmb-2018-0174DOI Listing
November 2018
10 Reads

Recognition and management of febrile convulsions in children.

Br J Nurs 2018 Nov;27(20):1156-1162

Consultant Paediatrician, Torbay Hospital, Torquay.

Febrile convulsions (FCs) are characterised by convulsions associated with fever in children aged between 6 months and 6 years. FCs are relatively common and affect 3-4% of children in western countries. This is the most common seizure disorder seen in children. Read More

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http://dx.doi.org/10.12968/bjon.2018.27.20.1156DOI Listing
November 2018
1 Read

Adenovirus-Associated Central Nervous System Disease in Children.

J Pediatr 2019 Feb 6;205:130-137. Epub 2018 Nov 6.

Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada; Division of Infectious Diseases, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

Objective: To characterize the spectrum and salient clinical features of adenovirus-associated neurologic disease in immunocompetent children.

Study Design: Previously healthy children (aged 1 month-18 years) with central nervous system (CNS) disease associated with adenovirus infection were identified via the Encephalitis Registry (1996-2016) and Microbiology Database (2000-2016) at The Hospital for Sick Children, Toronto, and by systematic review of the literature. The data were pooled and analyzed to identify the spectrum of illness, clinical outcome, and risk factors for death or neurologic impairment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223476183136
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http://dx.doi.org/10.1016/j.jpeds.2018.09.036DOI Listing
February 2019
18 Reads

Limited Correlation of Shotgun Metagenomics Following Host Depletion and Routine Diagnostics for Viruses and Bacteria in Low Concentrated Surrogate and Clinical Samples.

Front Cell Infect Microbiol 2018 23;8:375. Epub 2018 Oct 23.

Biology Division, Spiez Laboratory, Swiss Federal Office for Civil Protection, Spiez, Switzerland.

The etiologic cause of encephalitis, meningitis or meningo-encephalitis is unknown in up to 70% of cases. Clinical shotgun metagenomics combined with host depletion is a promising technique to identify infectious etiologies of central nervous system (CNS) infections. We developed a straightforward eukaryotic host nucleic acid depletion method that preserves intact viruses and bacteria for subsequent shotgun metagenomics screening of clinical samples, focusing on cerebrospinal fluid (CSF). Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00375
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http://dx.doi.org/10.3389/fcimb.2018.00375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206298PMC
October 2018
9 Reads

Pediatric Bilateral Facial Paralysis: An Unusual Presentation of Lyme Disease.

Pediatr Emerg Care 2018 Oct 25. Epub 2018 Oct 25.

Department of Pediatrics and Emergency Medicine, Section of Pediatric Emergency Medicine, Yale University School of Medicine, New Haven, CT.

Pediatric bilateral facial nerve paralysis (FNP) is a rare condition, representing less than 2% of all cases of FNP. The differential diagnosis of FNP is extensive (ranging from infectious, traumatic, neurologic, to idiopathic) and often can present as a diagnostic challenge. In contrast to unilateral presentation, bilateral FNP presents as a manifestation of serious systemic conditions, including meningitis (infectious and neoplastic), brain stem encephalitis, Guillain-Barre syndrome, sarcoidosis, Lyme disease, human immunodeficiency virus infection, leukemia, and vasculitis. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001648DOI Listing
October 2018
21 Reads

Strategies to improve detection and management of human parechovirus infection in young infants.

Lancet Infect Dis 2019 Feb 12;19(2):e51-e58. Epub 2018 Oct 12.

Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Vaccine Evaluation Center, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.

Human parechovirus infections are the second most common cause of viral meningitis in children. These infections are most frequently seen in infants younger than 90 days. Clinical manifestations include encephalitis, meningitis, myocarditis, and sepsis, which can lead to serious neurodevelopmental sequelae in young infants. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14733099183028
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http://dx.doi.org/10.1016/S1473-3099(18)30288-3DOI Listing
February 2019
15 Reads

Rapid Therapeutic Response of Eosinophilic Meningoencephalitis in a Toddler With Infection.

WMJ 2018 Aug;117(3):130-132

Department of Hospital Medicine, Children's Hospital of Wisconsin, Milwaukee, Wisconsin.

Introduction: Eosinophilic meningitis is an infrequently encountered condition. (raccoon roundworm) infection, rarely diagnosed in North America, is a known cause of eosinophilic meningitis, often producing death or permanent neurologic damage.

Case Report: We recently encountered a toddler with geophagia and probable exposure to raccoon feces, who presented with eosinophilic meningitis and encephalitis, and was diagnosed with infection and possible Toxocara co-infection. Read More

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August 2018
15 Reads

Coxsackievirus B5 Aseptic Meningitis in Infants in Chiba Prefecture, Japan, in 2016.

J Nippon Med Sch 2018 ;85(3):187-190

Department of Pediatrics, Nippon Medical School Chiba Hokusoh Hospital.

Background: Infantile aseptic meningitis is a rare infection of the central nervous system. Coxsackievirus B5 (CVB5) is an enterovirus that is sometimes associated with aseptic meningitis and encephalitis.

Case Presentation: We report on three isolated infants with aseptic meningitis caused by CVB5 in the spring and summer of 2016 with nearly identical 404-bp CVB5 Viral Capsid Protein 1 (VP1) sequences. Read More

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http://dx.doi.org/10.1272/jnms.JNMS.2018_85-28DOI Listing
October 2018
16 Reads

Acute peripheral facial paralysis following varicella infection: An uncommon complication.

Turk J Pediatr 2018 ;60(1):99-101

Division of Pediatric Infectious Diseases, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Hanalioğlu D, Özsürekci Y, Büyükçam A, Gültekingil-Keser A, Tekşam Ö, Ceyhan M. Acute peripheral facial paralysis following varicella infection: An uncommon complication. Turk J Pediatr 2018; 60: 99-101. Read More

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http://dx.doi.org/10.24953/turkjped.2018.01.016DOI Listing
January 2019
18 Reads

Factors associated with severe neurologic complications in patients with either hand-foot-mouth disease or herpangina: A nationwide observational study in South Korea, 2009-2014.

PLoS One 2018 10;13(8):e0201726. Epub 2018 Aug 10.

Department of Pediatrics, Hanyang University College of Medicine, Seoul, South Korea.

Background: In 2009, a nationwide sentinel surveillance for hand-foot-mouth disease (HFMD) and herpangina (HA) with neurologic complications was initiated in South Korea. We used this surveillance system to investigate the clinical characteristics of patients with either HFMD or HA with neurologic complications, with the aim of determining risk factors for severe neurologic complications.

Methods: A retrospective review of medical records was conducted on all cases of HFMD and HA with neurologic complications that were reported in the national system between April 1, 2009 and December 31, 2014. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201726PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086402PMC
February 2019
9 Reads

Expanding Molecular Diagnostics for Central Nervous System Infections.

Adv Pediatr 2018 Aug 20;65(1):209-227. Epub 2018 Jun 20.

Department of Pediatrics, University of South Florida, College of Medicine, 2 Tampa General Circle, 5th Floor, STC 5016, Tampa, FL 33606, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yapd.2018.04.005DOI Listing
August 2018
3 Reads

Epidemiology and clinical outcomes of viral central nervous system infections.

Int J Infect Dis 2018 Aug 18;73:85-90. Epub 2018 Jun 18.

Department of Medicine, Division of Infectious Diseases, Hamad Medical Corporation, Doha, Qatar; Weill Cornell Medical College, New York, NY, USA and Doha, Qatar.

Background: Central nervous system (CNS) viral infections are an important cause of morbidity and mortality. No data are available regarding their epidemiology in Qatar.

Design: We retrospectively evaluated all cerebrospinal fluid findings from January 2011-March 2015 at Hamad Medical Corporation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712183444
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http://dx.doi.org/10.1016/j.ijid.2018.06.008DOI Listing
August 2018
9 Reads

Complications of Listeria meningitis in two immunocompetent children.

Pediatr Int 2018 May;60(5):491-492

Department of Pediatrics, Kawaguchi Municipal Medical Center, Kawaguchi, Japan.

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http://dx.doi.org/10.1111/ped.13550DOI Listing
May 2018
5 Reads

Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS).

Crit Care 2018 05 31;22(1):143. Epub 2018 May 31.

Institute of Cellular Medicine, Newcastle University, 4th Floor, William Leech Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

Background: Sepsis is one of the main reasons for non-elective admission to pediatric intensive care units (PICUs), but little is known about determinants influencing outcome. We characterized children admitted with community-acquired sepsis to European PICUs and studied risk factors for mortality and disability.

Methods: Data were collected within the collaborative Seventh Framework Programme (FP7)-funded EUCLIDS study, which is a prospective multicenter cohort study aiming to evaluate genetic determinants of susceptibility and/or severity in sepsis. Read More

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http://dx.doi.org/10.1186/s13054-018-2052-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984383PMC
May 2018
10 Reads

Multiplex PCR reveals high prevalence of enterovirus and HHV6 in acellular paediatric cerebrospinal fluid samples.

J Infect 2018 Sep 29;77(3):249-257. Epub 2018 May 29.

Microbiology Department, Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust, Mandeville Road, Bucks HP21 8AL, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S01634453183016
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http://dx.doi.org/10.1016/j.jinf.2018.05.008DOI Listing
September 2018
7 Reads
4.441 Impact Factor

Into Darkness and Silence: What Caused Helen Keller's Deafblindness?

Authors:
Janet R Gilsdorf

Clin Infect Dis 2018 Oct;67(9):1445-1449

Department of Pediatrics, University of Michigan Medical School, Ann Arbor.

In 1882, at 19 months of age, Helen Keller developed a febrile illness that left her both deaf and blind. Historical biographies attribute the illness to rubella, scarlet fever, encephalitis, or meningitis. This analysis of her illness suggests she likely had bacterial meningitis, caused by Neisseria meningitidis or possibly Haemophilus influenzae. Read More

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http://dx.doi.org/10.1093/cid/ciy385DOI Listing
October 2018
9 Reads

Congenital Cytomegalovirus Pneumonitis and Treatment Response Evaluation Using Viral Load during Ganciclovir Therapy: a Case Report.

Jpn J Infect Dis 2018 Jul 27;71(4):309-311. Epub 2018 Apr 27.

Department of Pediatrics, National Center for Global Health and Medicine.

Cytomegalovirus (CMV) is the most common cause of congenital infection. Pneumonitis is considered to be a rare manifestation although congenital CMV infection presents with various non-specific findings. Ganciclovir and valganciclovir are beneficial for improving neurodevelopmental sequelae and hearing outcomes of congenital CMV infection; however, treatment response evaluation is not well reported. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2017.577DOI Listing
July 2018
5 Reads

Does intra-individual neurocognitive variability relate to neuroinvasive disease and quality of life in West Nile Virus?

J Neurovirol 2018 Aug 25;24(4):506-513. Epub 2018 Apr 25.

Baylor College of Medicine, Department of Pediatrics, Section of Pediatric Tropical Medicine, National School of Tropical Medicine, Houston, TX, USA.

West Nile Virus (WNV) can be a neuroinvasive pathogen that may produce persistent mild-to-moderate neurocognitive impairments in some infected persons. Intra-individual variability (IIV) is an index of a person's performance across a neuropsychological test or battery, which is an indicator of neurocognitive control and integrity of prefrontal systems. The present study examined possible associations of IIV to neurological health and well-being in WNV infection. Read More

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http://dx.doi.org/10.1007/s13365-018-0641-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105392PMC
August 2018
14 Reads

Retrospective Evaluation of Infants Aged 1 to 60 Days with Residual Cerebrospinal Fluid (CSF) Tested Using the FilmArray Meningitis/Encephalitis (ME) Panel.

J Clin Microbiol 2018 Jul 25;56(7). Epub 2018 Jun 25.

BioFire Diagnostics, LLC, Salt Lake City, Utah, USA.

In pediatric practice it is common for infants under 2 months of age to undergo evaluation for sepsis when they are ill, often including lumbar puncture to assess for central nervous system (CNS) infection. The FilmArray Meningitis/Encephalitis (ME) panel is a newly approved test for rapid identification of CNS pathogens. Our objective was to study the epidemiology of CNS infection in young infants and the potential impact of rapid multiplex PCR on their care. Read More

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http://jcm.asm.org/lookup/doi/10.1128/JCM.00277-18
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http://dx.doi.org/10.1128/JCM.00277-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018345PMC
July 2018
25 Reads

Acute Motor Axonal Polyneuropathy Following Mumps Infection in a 9-Year-Old Girl.

J Trop Pediatr 2019 Feb;65(1):98-100

Department of Paediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

A 9-year-old girl presented with lower motor neuron type of paralysis involving limbs, trunk and multiple cranial nerves (7, 9 and 10) with preceding history of mumps 1 week before the onset of weakness. There were no features to suggest either a meningitis or encephalitis in the child. Cerebrospinal fluid showed hypoglycorrhachia and mild protein elevation; magnetic resonance imaging of the brain was normal. Read More

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http://dx.doi.org/10.1093/tropej/fmy018DOI Listing
February 2019
4 Reads

Detection of Neisseria meningitidis in a paediatric patient with septic arthritis using multiplexed diagnostic PCR targeting meningitis/encephalitis (ME).

Ann Clin Microbiol Antimicrob 2018 Mar 23;17(1):14. Epub 2018 Mar 23.

Centre for Interventions in Infection, Inflammation & Immunity (4i) and Graduate Entry Medical School, University of Limerick, Limerick, Ireland.

Background: Neisseria meningitidis is associated with meningitis and septicemia. Septic meningococcal arthritis is relatively uncommon and its diagnosis associated with clinical and microbiological challenges. Early recognition and treatment is required to prevent joint destruction. Read More

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https://ann-clinmicrob.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12941-018-0268-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865334PMC
March 2018
14 Reads

Pediatric Acute Severe Neurologic Illness and Injury in an Urban and a Rural Hospital in the Democratic Republic of the Congo.

Am J Trop Med Hyg 2018 May 1;98(5):1534-1540. Epub 2018 Mar 1.

The Ohio State University, Columbus, Ohio.

Empirical knowledge suggests that acute neurologic disorders are common in sub-Saharan Africa, but studies examining the true burden of these diseases in children are scarce. We performed this prospective, observational study to evaluate the prevalence, clinical characteristics, treatment approaches, and outcomes of children suffering acute neurologic illness or injury (ANI) in an urban and rural site in the Democratic Republic of the Congo. Over 12 months, 471 out of 6,563 children admitted met diagnostic criteria for ANI, giving a hospital-based prevalence of 72/1,000 admissions. Read More

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http://dx.doi.org/10.4269/ajtmh.17-0784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953377PMC
May 2018
2 Reads

The association of endothelial nitric oxide synthase gene single nucleotide polymorphisms with paediatric systemic lupus erythematosus.

Clin Exp Rheumatol 2018 May-Jun;36(3):508-512. Epub 2018 Jan 31.

Division of Paediatric Rheumatology, The Affiliated Children's Hospital, Capital Institute of Paediatrics, Beijing, China.

Objectives: Endothelial nitric oxide synthase (eNOS) is a type of nitric oxide synthase that mainly exists in the endothelium. It produces nitric oxide (NO) to regulate the function of endothelial cells. Endothelial dysfunction and increased NO metabolites have been shown in animal models of lupus and in lupus patients, so eNOS gene polymorphisms may be important in the pathogenesis of SLE. Read More

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July 2018
11 Reads

Utility of the Performance of Lumbar Puncture for Febrile Children With Status Epilepticus in the Bacterial Conjugate Vaccine Era.

Pediatr Infect Dis J 2018 Oct;37(10):963-966

From the Department of Pediatrics, School of Medicine, University of Occupational and Environment Health.

Background: The necessity of lumbar puncture for the differentiation of central nervous system infection in children with febrile status epilepticus (FSE) remains controversial. The aim of the present study is to investigate the diagnostic necessity of lumbar puncture for children with FSE after the introduction of bacterial conjugate vaccines into the infant immunization program.

Methods: Our retrospective cohort study was performed in children 6 to 60 months of age who were admitted to the pediatric ward at Kitakyushu General Hospital from January 1, 2011, to December 31, 2015, for seizures with fever. Read More

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http://dx.doi.org/10.1097/INF.0000000000001945DOI Listing
October 2018
12 Reads

Principles of Management of Central Nervous System Infections.

Indian J Pediatr 2019 Jan 15;86(1):52-59. Epub 2018 Jan 15.

Department of Pediatrics, Government Medical College and Hospital, Sector 32, Chandigarh, India.

CNS infections in children are medical emergency and are associated with high mortality and morbidity. For diagnosis, a high index of suspicion is required. Clinical assessment should be supplemented by laboratory investigations including CSF Gram stain and cultures, blood culture, PCR on CSF, serological tests, and imaging. Read More

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http://dx.doi.org/10.1007/s12098-017-2583-yDOI Listing
January 2019
5 Reads

Tropical Fevers in Indian Intensive Care Units: A Prospective Multicenter Study.

Indian J Crit Care Med 2017 Dec;21(12):811-818

Professor Emeritus Pathology, PGIMS, Rohtak, Haryana, India.

Background And Aims: Infections in tropics often present as undifferentiated fevers with organ failures. We conducted this nationwide study to identify the prevalence, profile, resource utilization, and outcome of tropical fevers in Indian Intensive Care Units (ICUs).

Materials And Methods: This was a multicenter prospective observational study done in 34 ICUs across India (July 2013-September 2014). Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_324_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752788PMC
December 2017
5 Reads

Unexpected Ventriculitis Complication of Neonatal Meningitis Caused by Streptococcus gallolyticus Subsp. pasteurianus: a Case Report.

Jpn J Infect Dis 2018 Jan 26;71(1):68-71. Epub 2017 Dec 26.

Department of Bacteriology I, National Institute of Infectious Diseases.

Streptococcus gallolyticus subsp. pasteurianus, previously recognized as S. bovis biotype II/2, is an uncommon yet important cause of invasive infection in young infants. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2017.053DOI Listing
January 2018
10 Reads

Encephalitis in US Children.

Infect Dis Clin North Am 2018 03 8;32(1):145-162. Epub 2017 Dec 8.

Department of Pediatrics, University of Colorado, Children's Hospital Colorado, B055, 13123 East 16th Avenue, Aurora, CO 80045, USA.

Encephalitis is an uncommon but severe disease characterized by neurologic dysfunction with central nervous system inflammation. Children with encephalitis should receive supportive care and empiric therapies for common and treatable causes while prioritizing diagnostic evaluation for common, treatable, and high-risk conditions. Even with an extensive diagnostic workup, an infectious cause is identified in less than half of cases, suggesting a role for postinfectious or noninfectious processes. Read More

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http://dx.doi.org/10.1016/j.idc.2017.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801071PMC
March 2018
8 Reads

Diagnostic Approach to Viral Acute Encephalitis Syndrome (AES) in Paediatric Age Group: A Study from New Delhi.

J Clin Diagn Res 2017 Sep 1;11(9):DC25-DC29. Epub 2017 Sep 1.

Phd Student, Department of Microbiology, Maulana Azad Medical College, New Delhi, New Delhi, India.

Introduction: Acute Encephalitis Syndrome has heralded the emergence of multiple virulent pathogens, which may result in severe morbidity and mortality. In India, encephalitis is not notified and there has been a dearth of analysis for trends in encephalitis death rates and causation. A downward trend has been observed in encephalitis deaths, due to 'known' causes, which can be largely explained by improvement in diagnostic, treatment, and prevention methods. Read More

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http://dx.doi.org/10.7860/JCDR/2017/27413.10648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713729PMC
September 2017
14 Reads

Intracranial complications of midline nasal dermoid cysts.

Acta Chir Belg 2017 Dec 4:1-4. Epub 2017 Dec 4.

a Department of Plastic Surgery , Gent University , Gent , Belgium.

Background: Nasal dermoid cysts are common tumors in children. Due to anomalies in embryologic development of the nasal complex, sometimes an intracranial extension exists. When these cysts become infected they can lead to meningitis, brain abscess and death. Read More

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http://dx.doi.org/10.1080/00015458.2017.1411552DOI Listing
December 2017
12 Reads

Fungal and Parasitic CNS Infections.

Indian J Pediatr 2019 Jan 11;86(1):83-90. Epub 2017 Nov 11.

Pediatric Neurology and Neurodevelopment Unit, Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Central nervous system fungal infections can be broadly divided into those that infect a healthy host such as Cryptococcus, Coccidioides, Histoplasma, Blastomyces, Sporothrix spp., and those that cause opportunistic infections in an immunocompromised host such as Candida, Aspergillus, Zygomycetes, Trichosporon spp. The clinical manifestations of central nervous system fungal infections commonly seen in children in clinical practice include a chronic meningitis or meningoencephalitis syndrome, brain abscess, rhino-cerebral syndrome and rarely, a fungal ventriculitis. Read More

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http://dx.doi.org/10.1007/s12098-017-2487-xDOI Listing
January 2019
12 Reads

Pseudotumoral cerebellitis with acute hydrocephalus as a manifestation of EBV infection.

Rev Neurol (Paris) 2018 Jan - Feb;174(1-2):70-72. Epub 2017 Nov 3.

Department of Paediatrics, CHR Namur, Namur, Belgium.

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http://dx.doi.org/10.1016/j.neurol.2017.06.015DOI Listing
November 2018
2 Reads

Neuropsychological and internalizing problems in acute central nervous system infections: a 1 year follow-up.

Ital J Pediatr 2017 Oct 24;43(1):96. Epub 2017 Oct 24.

Pediatric and Infectious Diseases Unit, IRCCS Bambino Gesù Children Hospital, Rome, Italy.

Background: Acute central nervous system (ACNS) infections such as meningitis, encephalitis and cerebellitis still cause morbidity and mortality among children. The aim of this study was to verify whether neuropsychological impairment may develop in ACNS survivors.

Methods: The study included pediatric patients affected by ACNS disorders, aged 3-16 years admitted to the Bambino Gesù Children Hospital, Rome from June 2013 till June 2015. Read More

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http://dx.doi.org/10.1186/s13052-017-0416-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655874PMC
October 2017
9 Reads

Three children of meningoencephalitis with Kikuchi necrotizing lymphadenitis.

Brain Dev 2018 Mar 16;40(3):251-255. Epub 2017 Oct 16.

Department of Pediatrics, Pusan National University Children's Hospital, Yangsan, Republic of Korea; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea. Electronic address:

Background: Kikuchi necrotizing lymphadenitis (KNL) is a rare and benign cause of lymphadenopathy, most often cervical. The etiology of KNL remains unknown. Central nervous system (CNS) involvement, such as in meningoencephalitis, is a very rare clinical manifestation of KNL, especially in children. Read More

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http://dx.doi.org/10.1016/j.braindev.2017.09.009DOI Listing
March 2018
10 Reads

Post-licensure safety surveillance study of routine use of quadrivalent meningococcal diphtheria toxoid conjugate vaccine.

Vaccine 2017 12 21;35(49 Pt B):6879-6884. Epub 2017 Sep 21.

Kaiser Permanente Vaccine Study Center, 1 Kaiser Plaza 16B, Oakland, CA 94612, USA.

Background: Menactra® vaccine (MenACWY-D) was licensed in the United States in 2005 for persons 11-55years of age. The aim of this study was to assess the safety of MenACWY-D administered as part of routine clinical care to patients at Kaiser Permanente Northern California (KPNC).

Methods: This was an observational, retrospective study that included all KPNC members who received MenACWY-D during the study period. Read More

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http://dx.doi.org/10.1016/j.vaccine.2017.09.032DOI Listing
December 2017
28 Reads

A pediatric case with peripheral facial nerve palsy caused by a granulomatous lesion associated with cat scratch disease.

Brain Dev 2018 Feb 19;40(2):159-162. Epub 2017 Sep 19.

Kofu Municipal Hospital, Kofu, Japan.

Background: Cat scratch disease is a common infectious disorder caused by Bartonella henselae that is transmitted primarily by kittens. It typically exhibits a benign and self-limiting course of subacute regional lymphadenopathy and fever lasting two to eight weeks. The most severe complication of cat scratch disease is involvement of the nervous system, such as encephalitis, meningitis, and polyneuritis. Read More

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http://dx.doi.org/10.1016/j.braindev.2017.09.001DOI Listing
February 2018
13 Reads

Diagnostic Imaging and Invasive Fungal Diseases in Children.

J Pediatric Infect Dis Soc 2017 Sep;6(suppl_1):S22-S31

Transplantation-Oncology Infectious Diseases Program and Departments of Medicine, Pediatrics, Microbiology and Immunology, Weill Cornell Medicine of Cornell University and New York Presbyterian Hospital.

Invasive fungal disease (IFD) is a life-threatening condition, especially in immunocompromised children. The role of diagnostic imaging in children at risk for an IFD is multifactorial, including initially detecting it, evaluating for dissemination of infection beyond the primary site of disease, monitoring the response to antifungal therapy, and assessing for potential relapse. The objective of this review was to synthesize the published literature relevant to the use of various imaging modalities for the diagnosis and management of IFD in children. Read More

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http://dx.doi.org/10.1093/jpids/pix055DOI Listing
September 2017
10 Reads

If You Build It, They Will Come: Initial Experience with a Multi-Disciplinary Pediatric Neurocritical Care Follow-Up Clinic.

Children (Basel) 2017 Sep 19;4(9). Epub 2017 Sep 19.

Division of Pediatric Neurology, Department of Pediatrics, Oregon Health and Science University, 707 SW Gaines St, CDRC-P, Portland, OR 97239, USA.

Pediatric Neurocritical Care diagnoses account for a large proportion of intensive care admissions. Critical care survivors suffer high rates of long-term morbidity, including physical disability, cognitive impairment, and psychosocial dysfunction. To address these morbidities in Pediatric Neurocritical Care survivors, collaboration between Pediatric Neurology and Pediatric Critical Care created a multidisciplinary follow-up clinic providing specialized evaluations after discharge. Read More

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http://dx.doi.org/10.3390/children4090083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615273PMC
September 2017
3 Reads

Emergency Neurologic Life Support: Meningitis and Encephalitis.

Neurocrit Care 2017 Sep;27(Suppl 1):124-133

Department of Internal Medicine, Division of Critical Care, Boone Hospital Center, BJC Health Care, Columbia, MO, USA.

Bacterial meningitis and viral encephalitis, particularly herpes simplex encephalitis, are severe neurological infections that, if not treated promptly and effectively, lead to poor neurological outcome or death. Because of the value of early recognition and treatment, meningitis and encephalitis was chosen as an Emergency Neurological Life Support protocol. This protocol provides a practical approach to recognition and urgent treatment of bacterial meningitis and encephalitis. Read More

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http://dx.doi.org/10.1007/s12028-017-0455-yDOI Listing
September 2017
18 Reads

Severe Complications of Mumps.

Indian Pediatr 2017 08;54(8):689

Department of *Pediatrics and #Medicine Velammal Medical College Hospital and Research Institute, Madurai, Tamilnadu, India.

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August 2017
1 Read

Aseptic meningitis in adults and children: Diagnostic and management challenges.

J Clin Virol 2017 09 4;94:110-114. Epub 2017 Aug 4.

Division of Infectious Diseases, Department of Internal Medicine, University of Texas (UT) Health Science Center, Houston, TX, USA. Electronic address:

Background: Aseptic meningitis represents a common diagnostic and management dilemma to clinicians.

Objectives: To compare the clinical epidemiology, diagnostic evaluations, management, and outcomes between adults and children with aseptic meningitis.

Study Design: We conducted a retrospective study from January 2005 through September 2010 at 9 Memorial Hermann Hospitals in Houston, TX. Read More

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http://dx.doi.org/10.1016/j.jcv.2017.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581214PMC
September 2017
21 Reads

Type 1-skewed neuroinflammation and vascular damage associated with Orientia tsutsugamushi infection in mice.

PLoS Negl Trop Dis 2017 Jul 24;11(7):e0005765. Epub 2017 Jul 24.

Department of Ophthalmology, Institute of Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America.

Background: Scrub typhus is a life-threatening disease, due to infection with O. tsutsugamushi, a Gram-negative bacterium that preferentially replicates in endothelial cells and professional phagocytes. Meningoencephalitis has been reported in scrub typhus patients and experimentally-infected animals; however, the neurological manifestation and its underlying mechanisms remain poorly understood. Read More

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http://dx.doi.org/10.1371/journal.pntd.0005765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542690PMC
July 2017
12 Reads

An outbreak of echovirus 18 encephalitis/meningitis in children in Hebei Province, China, 2015.

Emerg Microbes Infect 2017 06 21;6(6):e54. Epub 2017 Jun 21.

MOE Key Laboratory of Major Diseases in Children, National Key Discipline of Pediatrics, National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.

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http://dx.doi.org/10.1038/emi.2017.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584482PMC
June 2017
10 Reads