1,700 results match your criteria Pediatrics Measles


First Report of a Disease by Rhazes 10 Centuries Ago.

Int J Prev Med 2019 15;10. Epub 2019 Jan 15.

Department of Anesthesiology and Intensive Care Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Abu Bakr Mohammad Ibn Zakariya Al-Razi (865-925 CE), who was known as "Rhazes" in the west, was a famous scientist of medieval ages. He has more than 200 books and treatises. His masterpiece on medicine "" contains around 900 case reports. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_216_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360843PMC
January 2019

Protection against varicella with two doses of combined measles-mumps-rubella-varicella vaccine or one dose of monovalent varicella vaccine: 10-year follow-up of a phase 3 multicentre, observer-blind, randomised, controlled trial.

Lancet Infect Dis 2019 Feb 11. Epub 2019 Feb 11.

University of Defence, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic; Charles University, Faculty of Medicine in Hradec Kralove, Department of Social Medicine, Hradec Kralove, Czech Republic.

Background: The duration of protection provided by varicella vaccines is unclear. We assessed the 10-year vaccine efficacy of two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV), one live attenuated varicella vaccine (V) dose given after one measles-mumps-rubella vaccine (MMR) dose (MMR + V), versus two MMR doses (control vaccine) for the prevention of confirmed varicella.

Methods: This was a phase 3b follow-up of an observer-blinded, randomised, controlled trial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14733099183071
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http://dx.doi.org/10.1016/S1473-3099(18)30716-3DOI Listing
February 2019
3 Reads

Early disappearance of maternal anti-measles, mumps, rubella, and varicella antibodies in Indian infants.

Vaccine 2019 Feb 11. Epub 2019 Feb 11.

Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed To Be University), Pune, India. Electronic address:

Background: Immunization of children with vaccines against Measles, Mumps, Rubella, and Varicella (MMRV) is practiced globally with varied recommendations. In India, measles vaccine is administered alone or as MMR at 9 months age. Varicella vaccine is not routinely used. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193011
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http://dx.doi.org/10.1016/j.vaccine.2019.01.043DOI Listing
February 2019
1 Read

Barriers to effective uptake and provision of immunization in a rural district in Uganda.

PLoS One 2019 14;14(2):e0212270. Epub 2019 Feb 14.

Sefako Makgatho Health Sciences University, Pretoria, South Africa.

Introduction: Hoima, one of the largest districts in mid- western Uganda, has persistently performed poorly with low immunization coverage, high immunization drop outs rates and repeated outbreaks of vaccine preventable diseases especially measles. The objectives of this study were to evaluate the state of immunization services and to identify the gaps in immunization health systems that contribute to low uptake and completion of immunization schedules in Hoima District.

Methods: This was a cross sectional mixed methods study, utilizing both qualitative and quantitative approaches. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212270PLOS
February 2019

Vaccination Against Measles, Mumps, and Rubella in the Light of Current Epidemic Threats: Unjustified Postponement.

Adv Exp Med Biol 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatrics with Clinical Assessment Unit, Warsaw Medical University, Warsaw, Poland.

A worrying increase in the number of measles cases has been noted recently in Poland, which may have to do with a decreasing proportion of children vaccinated against measles, mumps, and rubella (MMR) in the second year of life (<95%). For many years, MMR vaccination in children has been associated with a fear of allergy to eggs. This study seeks to define the reason and justification for postponing MMR vaccination in a population of children referred to the outpatient specialist immunization clinic. Read More

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http://dx.doi.org/10.1007/5584_2019_344DOI Listing
February 2019

Indian Academy of Pediatrics (IAP) Advisory Committee on Vaccines and Immunization Practices (ACVIP) Recommended Immunization Schedule (2018-19) and Update on Immunization for Children Aged 0 Through 18 Years.

Indian Pediatr 2018 Dec;55(12):1066-1074

Advisory Committee on Vaccines and Immunization Practices (ACVIP), Indian Academy of Pediatrics, India.

Justification: There is a need to revise/review recommendations regarding existing vaccines in view of current developments in vaccinology.

Process: Advisory Committee on Vaccines and Immunization Practices (ACVIP) of Indian Academy of Pediatrics (IAP) reviewed the new evidence, had two meetings, and representatives of few vaccine manufacturers also presented their data. The recommendations were finalized unanimously. Read More

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December 2018
5 Reads

Measles virus bearing MIBE-derived fusion protein is pathogenic after infection via the respiratory route.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Center for Host-Pathogen Interaction, Columbia University Medical Center, New York, USA

A clinical isolate of measles virus (MeV) bearing a single amino acid alteration in the viral fusion protein (F; L454W) was previously identified in two patients with lethal sequelae of MeV central nervous system (CNS) infection. The mutation dysregulated the viral fusion machinery so that the mutated F protein mediated cell fusion in the absence of known MeV cellular receptors. While this virus could feasibly have arisen via intra-host evolution of the wildtype (wt) virus, it was recently shown that the same mutation emerged under the selective pressure of small molecule antiviral treatment. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.01862-18
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http://dx.doi.org/10.1128/JVI.01862-18DOI Listing
February 2019
3 Reads

Maternal Priming: Bacillus Calmette-Guérin (BCG) Vaccine Scarring in Mothers Enhances the Survival of Their Child With a BCG Vaccine Scar.

J Pediatric Infect Dis Soc 2019 Feb 3. Epub 2019 Feb 3.

Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau.

Background And Hypothesis: Maternal priming might enhance the beneficial nonspecific effects (NSEs) of live measles vaccination (MV). Children with a bacillus Calmette-Guérin (BCG) vaccine scar have a lower mortality rate than those without a scar that is not explained by protection against tuberculosis. We examined the hypothesis that BCG scarring would have a stronger effect on a child if the mother also had a BCG scar. Read More

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http://dx.doi.org/10.1093/jpids/piy142DOI Listing
February 2019
1 Read

Reliability and accuracy of smartphones for paediatric infectious disease consultations for children with rash in the paediatric emergency department.

BMC Pediatr 2019 Jan 31;19(1):40. Epub 2019 Jan 31.

Department of Pediatric Emergency Department, Dr. Behçet Uz Children's Hospital, İzmir, Turkey.

Objective: Smartphones and associated messaging applications have become the most common means of communication among health care workers and the general population. The aim of this study was to evaluate the reliability and accuracy of smartphones for the diagnosis of rash in children admitted to emergency departments during the night shift.

Methods: The images of the children who were admitted to the paediatric emergency department with rash were included in this study, and at least two images taken with smartphones by residents or paediatric infectious disease fellows were re-directed to the chief consultant of the Paediatric-Infectious Department via smartphone. Read More

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http://dx.doi.org/10.1186/s12887-019-1416-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354364PMC
January 2019
1 Read

Subacute sclerosing panencephalitis: clinical phenotype, epidemiology, and preventive interventions.

Dev Med Child Neurol 2019 Jan 25. Epub 2019 Jan 25.

Paediatric Neurology Division, Department of Paediatrics and Child Health, Neuroscience Institute, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.

Subacute sclerosing panencephalitis (SSPE) is a preventable condition reported in 6.5 to 11 per 100 000 cases of measles, and highest in children who contracted measles infection when they were less than 5 years of age. Children residing in areas with poor vaccination coverage and high prevalence of human immunodeficiency virus are at increased risk of developing SSPE. Read More

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http://doi.wiley.com/10.1111/dmcn.14166
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http://dx.doi.org/10.1111/dmcn.14166DOI Listing
January 2019
4 Reads

Subacute Sclerosing Panencephalitis Presenting as Choreoathetosis and Basal Ganglia Hyperintensities.

Neurohospitalist 2019 Jan 16;9(1):26-29. Epub 2018 May 16.

Pediatric Neurology and Neurodevelopment Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Subacute sclerosing panencephalitis is a devastating neurodegenerative disorder characterized by cognitive and memory deterioration, personality changes, behavior abnormalities, and a steady motor decline. Extrapyramidal manifestations are commonly seen in the advanced stage of the disease. We discuss a 10-year-old boy with subacute sclerosing panencephalitis presenting with generalized choreoathetosis, myoclonus, and cognitive decline. Read More

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http://dx.doi.org/10.1177/1941874418776902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327246PMC
January 2019

Does India Need a Universal High-Dose Vitamin A Supplementation Program?

Indian J Pediatr 2019 Jan 14. Epub 2019 Jan 14.

Department of Pediatrics and Clinical Epidemiology, Sitaram Bhartia Institute of Science and Research, Qutab Institutional Area, New Delhi, India.

High dose vitamin A (HDVA) concentrate began to be distributed in India in 1970 as a short-term, stop-gap approach to reduce clinical signs of vitamin A deficiency. As this problem declined globally, the purpose of distributing them changed to the reduction of young child mortality. However, their impact on this has also declined, if not disappeared, as suggested in India by the enormous DEVTA study. Read More

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http://dx.doi.org/10.1007/s12098-018-02851-xDOI Listing
January 2019
1 Read

Complications and risk factors for severe outcome in children with measles.

Arch Dis Child 2019 Jan 12. Epub 2019 Jan 12.

Pediatric Infectious Diseases Unit, Anna Meyer Children's University Hospital, Florence, Italy.

Objective And Design: Risk factors for severe measles are poorly investigated in high-income countries. The Italian Society for Paediatric Infectious Diseases conducted a retrospective study in children hospitalised for measles from January 2016 to August 2017 to investigate the risk factors for severe outcome defined by the presence of long-lasting sequelae, need of intensive care or death.

Results: Nineteen hospitals enrolled 249 children (median age 14. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315290DOI Listing
January 2019
2 Reads

Eradicating measles - a call for an exceptional coordinated global effort.

J Infect Dis 2019 Jan 7. Epub 2019 Jan 7.

Kenya Paediatrics Association, Nairobi, Kenya.

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz011DOI Listing
January 2019
4 Reads
5.997 Impact Factor

No-Notice Mystery Patient Drills to Assess Emergency Preparedness for Infectious Diseases at Community Health Centers in New York City, 2015-2016.

J Community Health 2019 Jan 2. Epub 2019 Jan 2.

Bureau of Healthcare System Readiness, Office of Emergency Preparedness and Response, New York City Department of Health and Mental Hygiene, Queens, NY, USA.

Mystery patient drills using simulated patients have been used in hospitals to assess emergency preparedness for infectious diseases, but these drills have seldom been reported in primary care settings. We conducted three rounds of mystery patient drills designed to simulate either influenza-like illness (ILI) or measles at 41 community health centers in New York City from April 2015 through December 2016. Among 50 drills conducted, 49 successfully screened the patient-actor (defined as provision of a mask or referral to the medical team given concern of infection requiring potential isolation), with 35 (70%) drills completing screening without any challenges. Read More

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http://dx.doi.org/10.1007/s10900-018-00595-5DOI Listing
January 2019

Assessing the timeliness of vaccine administration in children under five years in India, 2013.

Vaccine 2019 Jan 27;37(4):558-564. Epub 2018 Dec 27.

Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Infectious Disease, Michigan Medicine, 1500 E Medical Center Drive, Ann Arbor, MI, USA.

Morbidity from vaccine-preventable diseases is high in India, but precise estimates of vaccination timeliness are difficult to compute because many children lack records of vaccination dates. This study assessed vaccination timeliness after accounting for right and left censoring of data. This cross-sectional study used the 2012-2013 District Level Household and Facility Survey in India. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.12.035DOI Listing
January 2019
2 Reads

Serologic Status of Routine Childhood Vaccines, Cytomegalovirus, and Epstein-Barr Virus in Children With Inflammatory Bowel Disease.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

Section of Paediatric Gastroenterology, Department of Paediatrics, University of Calgary, Calgary, Alberta, Canada.

Background: Data on the serologic status of childhood vaccines, cytomegalovirus (CMV) and Epstein-Barr virus (EBV), are limited in inflammatory bowel disease (IBD). Therefore, we evaluated vaccine coverage and seroprotection, along with CMV and EBV seropositivity, in pediatric IBD.

Methods: In a cross-sectional study, demographic data, IBD history, vaccine records, and serum for antibodies against measles, mumps, rubella, diphtheria, tetanus, varicella, hepatitis B (HBV), CMV, and EBV were collected from children with IBD. Read More

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http://dx.doi.org/10.1093/ibd/izy366DOI Listing
December 2018
3 Reads

Vaccination of healthcare workers: is mandatory vaccination needed?

Expert Rev Vaccines 2018 Dec 1. Epub 2018 Dec 1.

d First Department of Pediatrics , National and Kapodistrian University of Athens , Athens , Greece.

Introduction: Vaccinations of healthcare workers (HCWs) aim to directly protect them from occupational acquisition of vaccine-preventable diseases (VPDs) and to indirectly protect their patients and the essential healthcare infrastructure. However, outbreaks due to VPDs continue to challenge healthcare facilities and HCWs are frequently traced as sources of VPDs to vulnerable patients. In addition, HCWs were disproportionately affected during the current measles outbreak in Europe. Read More

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http://dx.doi.org/10.1080/14760584.2019.1552141DOI Listing
December 2018

IgA targeting on the α-molecular recognition element (α-MoRE) of viral phosphoprotein inhibits measles virus replication by interrupting formation and function of P-N complex intracellularly.

Antiviral Res 2019 Jan 28;161:144-153. Epub 2018 Nov 28.

Mucosal Immunity Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430071, China. Electronic address:

Secretory IgA (SIgA) antibody is unique for its capability to transit through epithelial cells by transcytosis and thus has opportunities and probabilities to interact with all viral components during viral replication which may result in the inhibition of viral replication intracellularly. Here, we report a novel IgA mAb 1D11-IgA against phosphoprotein (P) of measles virus (MV), which is able to interact specifically with P in MV infected Vero-pIgR cells grown in a two-chamber transwell system. The binding epitope of 1D11-IgA involves a key residue proline 23 in P protein, which is among the α-molecular recognition element (α-MoRE) of P and critical for N-P complex. Read More

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http://dx.doi.org/10.1016/j.antiviral.2018.11.014DOI Listing
January 2019
2 Reads

Improving immunization capacity in Ethiopia through continuous quality improvement interventions: a prospective quasi-experimental study.

Infect Dis Poverty 2018 Nov 30;7(1):119. Epub 2018 Nov 30.

Ethiopian Public Health Association, P.O. Box 7117, Addis Ababa, Ethiopia.

Background: Strong scientific evidence is needed to support low-income countries in building effective and sustainable immunization programs and proactively engaging in global vaccine development and implementation initiatives. This study aimed to implement and evaluate the effectiveness of system-wide continuous quality improvement (CQI) interventions to improve national immunization programme performance in Ethiopia.

Methods: The study used a prospective, quasi-experimental design with an interrupted time-series analysis to collect data from 781 government health sectors (556 healthcare facilities, 196 district health offices, and 29 zonal health departments) selected from developing and emerging regions in Ethiopia. Read More

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http://dx.doi.org/10.1186/s40249-018-0502-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267782PMC
November 2018
24 Reads

Analysis of a Subacute Sclerosing Panencephalitis Genotype B3 Virus from the 2009-2010 South African Measles Epidemic Shows That Hyperfusogenic F Proteins Contribute to Measles Virus Infection in the Brain.

J Virol 2019 Feb 5;93(4). Epub 2019 Feb 5.

Division of Medical Virology, Department of Pathology, University of Cape Town and National Health Laboratory Service, Cape Town, South Africa

During a measles virus (MeV) epidemic in 2009 in South Africa, measles inclusion body encephalitis (MIBE) was identified in several HIV-infected patients. Years later, children are presenting with subacute sclerosing panencephalitis (SSPE). To investigate the features of established MeV neuronal infections, viral sequences were analyzed from brain tissue samples of a single SSPE case and compared with MIBE sequences previously obtained from patients infected during the same epidemic. Read More

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http://dx.doi.org/10.1128/JVI.01700-18DOI Listing
February 2019
3 Reads

Prevalence and factors associated with incomplete immunization of children (12-23 months) in Kwabre East District, Ashanti Region, Ghana.

Arch Public Health 2018 19;76:67. Epub 2018 Nov 19.

1Department of Nutritional Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.

Background: Childhood immunization is one of the most cost effective health interventions but its rate has been declining recently in Ghana. Information on immunization coverage and determinants is needed to improve immunization programmes. The objective of this study was to determine the prevalence and factors associated with incomplete immunization of children (12-23 months) in Kwabre East District, Ghana. Read More

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https://archpublichealth.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s13690-018-0315-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240961PMC
November 2018
8 Reads

Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands.

Nat Commun 2018 11 23;9(1):4944. Epub 2018 Nov 23.

Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.

Measles causes a transient immune suppression, leading to increased susceptibility to opportunistic infections. In experimentally infected non-human primates (NHPs) measles virus (MV) infects and depletes pre-existing memory lymphocytes, causing immune amnesia. A measles outbreak in the Dutch Orthodox Protestant community provided a unique opportunity to study the pathogenesis of measles immune suppression in unvaccinated children. Read More

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http://www.nature.com/articles/s41467-018-07515-0
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http://dx.doi.org/10.1038/s41467-018-07515-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251901PMC
November 2018
12 Reads

Determinants of low measles vaccination coverage in children living in an endemic area.

Eur J Pediatr 2019 Feb 14;178(2):243-251. Epub 2018 Nov 14.

Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, Via Pansini 5, 80131, Naples, Italy.

Measles outbreaks were recently reported in Europe due to low immunization rates. In this scenario, identifying the reasons of no vaccination is crucial to set up strategies to improve immunization rate. A cross-sectional study was conducted to investigate the determinants of missed vaccination in children living in Southern Italy, during the 2016 outbreak. Read More

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http://link.springer.com/10.1007/s00431-018-3289-5
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http://dx.doi.org/10.1007/s00431-018-3289-5DOI Listing
February 2019
17 Reads

Implementing Universal Varicella Vaccination in Europe: The Path Forward.

Pediatr Infect Dis J 2019 Feb;38(2):181-188

University of Tampere Medical School, Tampere, Finland.

Varicella is a common vaccine-preventable disease that usually presents as a mild disorder but can lead to severe complications. Before the implementation of universal varicella vaccination (UVV) in some European countries, the burden of varicella disease was broadly similar across the region. Despite this, countries adopted heterogeneous varicella vaccination strategies. Read More

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http://dx.doi.org/10.1097/INF.0000000000002233DOI Listing
February 2019
5 Reads

Measles and Rubella Seroprevalence in Mother-Infant Pairs in Rural Nepal and the United States: Pre- and Post-Elimination Populations.

Am J Trop Med Hyg 2018 Nov;99(5):1342-1345

Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington.

We sought to compare seroprevalence of protective measles and rubella-specific antibody in mother-infant pairs across two populations: a pre-disease elimination Nepal population with recently introduced rubella vaccine and post-disease elimination U.S. population. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.17-0836
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http://dx.doi.org/10.4269/ajtmh.17-0836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221218PMC
November 2018
10 Reads
2.699 Impact Factor

Attitudes and knowledge of healthcare workers on maternity and neonatal wards on measles disease and vaccination in the era of the current European epidemic.

Infect Dis (Lond) 2018 Oct 29:1-3. Epub 2018 Oct 29.

a Department of Paediatrics , University of Patras Medical School , Patras , Greece.

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http://dx.doi.org/10.1080/23744235.2018.1518589DOI Listing
October 2018
1 Read

secretor genotype and susceptibility to infections and chronic conditions in the ALSPAC cohort.

Wellcome Open Res 2018 25;3:65. Epub 2018 Sep 25.

Medical Research Council Integrative Epidemiology Unit, Avon Longitudinal Study of Parents and Children, Population Health Science, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.

The (fucosyltransferase-2) gene determines blood group secretor status. Being homozygous for the inactive "non-secretor" rs601338(A) allele confers resistance to certain infections (e.g. Read More

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https://wellcomeopenresearch.org/articles/3-65/v1
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http://dx.doi.org/10.12688/wellcomeopenres.14636.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171556.2PMC
September 2018
12 Reads

Clinical profile of measles in children with special reference to infants.

Trop Doct 2018 Oct 14:49475518804695. Epub 2018 Oct 14.

4 Junior Resident, Department of Paediatrics, Government Medical College, Kozhikode, Kerala, India.

This study was conducted to analyse the clinical characteristics of measles in infants and to compare them with those in older children. Clinical and sociodemographic details of all hospitalised children with suspected measles were recorded and confirmed cases were analysed further. Twenty-four infants and 34 children aged >1 year were included. Read More

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http://dx.doi.org/10.1177/0049475518804695DOI Listing
October 2018
3 Reads

Hong Kong Institute of Allergy and Hong Kong Society for Paediatric Immunology Allergy & Infectious Diseases joint consensus statement 2018 on vaccination in egg-allergic patients.

Hong Kong Med J 2018 Oct;24(5):527-531

Allergy Centre, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong.

Vaccination of egg-allergic individuals has been a historical concern, particularly for influenza and measles-mumps-rubella-varicella vaccines that are developed in chicken egg embryos or chicken cell fibroblasts. The egg proteins in these vaccines were believed to trigger an immediate allergic reaction in egg-allergic individuals. However, recently published international guidelines have updated their recommendations and now state that these vaccines can be safely administered to egg-allergic individuals. Read More

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http://dx.doi.org/10.12809/hkmj177137DOI Listing
October 2018
8 Reads

A long-term subacute sclerosing panencephalitis survivor treated with intraventricular interferon-alpha for 13 years.

Korean J Pediatr 2018 09 18. Epub 2018 Sep 18.

Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.

Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, and fatal central nervous system disorder resulting from persistent measles virus infection. Long-term data are scarce, with a maximum follow-up period of 10 years. Interferon-alpha (IFN-α) is a protein that exerts its antiviral activity via enhancement of cellular immune response and is reported to be an effective drug for the treatment of SSPE. Read More

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http://dx.doi.org/10.3345/kjp.2018.06730DOI Listing
September 2018
2 Reads

Measles: a disease often forgotten but not gone.

Hong Kong Med J 2018 Oct;24(5):512-520

Department of Pediatrics and Department of Laboratory Medicine and Pathology, The University of Alberta, Edmonton, Alberta, Canada.

Measles (rubeola) is a highly contagious vaccine-preventable disease caused by the measles virus-a virus of the family. The illness typically begins with fever, runny nose, cough, and pathognomonic enanthem (Koplik spots) followed by a characteristic erythematous, maculopapular rash. The rash classically begins on the face and becomes more confluent as it spreads cephalocaudally. Read More

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http://dx.doi.org/10.12809/hkmj187470DOI Listing
October 2018
7 Reads

Structure-Stability-Function Mechanistic Links in the Anti-Measles Virus Action of Tocopherol-Derivatized Peptide Nanoparticles.

ACS Nano 2018 Oct 24;12(10):9855-9865. Epub 2018 Sep 24.

Instituto de Medicina Molecular, Faculdade de Medicina , Universidade de Lisboa , 1649-028 Lisbon , Portugal.

Measles remains one of the leading causes of child mortality worldwide and is re-emerging in some countries due to poor vaccine coverage, concomitant with importation of measles virus (MV) from endemic areas. The lack of specific chemotherapy contributes to negative outcomes, especially in infants or immunodeficient individuals. Fusion inhibitor peptides derived from the MV Fusion protein C-terminal Heptad Repeat (HRC) targeting MV envelope fusion glycoproteins block infection at the stage of entry into host cells, thus preventing viral multiplication. Read More

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http://dx.doi.org/10.1021/acsnano.8b01422DOI Listing
October 2018
7 Reads

Science in the fight to uphold the rights of children.

PLoS Biol 2018 Sep 18;16(9):e3000010. Epub 2018 Sep 18.

Texas Children's Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology and Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America.

The United States is the only major nation to not yet have ratified the United Nations Convention on the Rights of the Child (UNCRC). Recently, there has been an erosion of the rights of children across America, Europe, and elsewhere, but through science, we may have an opportunity to counter some of this alarming trend. In the area of vaccines, the scientific community can raise its voice on the dangers that nonmedical exemptions and delays pose to children at risk for measles, influenza, and other childhood illnesses. Read More

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https://dx.doi.org/10.1371/journal.pbio.3000010
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http://dx.doi.org/10.1371/journal.pbio.3000010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143226PMC
September 2018
2 Reads

Rate of Recurrence of Adverse Events Following Immunization: Results of 19 Years of Surveillance Ii Quebec, Canada.

Pediatr Infect Dis J 2018 Sep 10. Epub 2018 Sep 10.

Department of social and preventive medicine, Laval University, Quebec, Canada.

Background: While adverse events following immunization (AEFI) are frequent, there are limited data on the safety of reimmunizing patients who had a prior AEFI. Our objective was to estimate the rate and severity of AEFI recurrences.

Methods: We analyzed data from the AEFI passive surveillance system in Quebec, Canada that collects information on reimmunization of patients who had a prior AEFI. Read More

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http://Insights.ovid.com/crossref?an=00006454-900000000-9653
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http://dx.doi.org/10.1097/INF.0000000000002162DOI Listing
September 2018
10 Reads

Congenital rubella syndrome surveillance in South Africa using a sentinel site approach: a cross-sectional study.

Clin Infect Dis 2018 Sep 8. Epub 2018 Sep 8.

National Institute for Communicable Diseases, A division of the National Health Laboratory Service, South Africa.

Background: Congenital rubella syndrome (CRS) includes disorders associated with intrauterine rubella infection. Incidence of CRS is higher in countries with no rubella-containing vaccines (RCV) in their immunization schedules. In the World Health Organization African region, RCVs are being introduced as part of the 2012-2020 global measles and rubella strategic plan. Read More

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http://dx.doi.org/10.1093/cid/ciy758DOI Listing
September 2018
14 Reads

Measles outbreak in a French Roma community in the Provence-Alpes-Côte d'Azur region, France, May to July 2017.

Int J Infect Dis 2018 11 7;76:97-101. Epub 2018 Sep 7.

Aix-Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France;

Objectives: To analyse a measles outbreak in a Roma community.

Methods: We describe a community-wide outbreak of genotype D8 measles that took place in southeastern France, between May and July 2017, along with the control measures adopted.

Results: We identified a total of eighteen cases, between six months and 24 years old. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.08.023DOI Listing
November 2018
10 Reads

Multimodal safety assessment of measles-mumps-rubella vaccination after pediatric liver transplantation.

Am J Transplant 2018 Sep 1. Epub 2018 Sep 1.

Department of Pediatrics, Division of General Pediatrics, Children's Hospital, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

Live-attenuated vaccines are currently contraindicated in solid-organ transplant recipients. However, the risk of vaccine-preventable infections is lifelong, and can be particularly severe after transplantation. In this prospective interventional national cohort study, 44 pediatric liver transplant recipients with measles IgG antibodies <150 IU/L (below seroprotection threshold) received measles-mumps-rubella vaccine (MMR) at a median of 6. Read More

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http://dx.doi.org/10.1111/ajt.15101DOI Listing
September 2018
3 Reads

Dominant SCN2A Mutation Causes Familial Episodic Ataxia and Impairment of Speech Development.

Neuropediatrics 2018 Dec 30;49(6):379-384. Epub 2018 Aug 30.

Division of Pediatric Neurology, Department of Pediatrics, University Hospital Cologne, Cologne, Germany.

Mutations in are associated with a heterogeneous clinical spectrum including epilepsy and autism. Here, we have identified a peculiar phenotype associated with vaccination related exacerbations of ataxia. We report the first family with three individuals affected by -associated episodic ataxia (EA) with impaired speech development. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1668141
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http://dx.doi.org/10.1055/s-0038-1668141DOI Listing
December 2018
11 Reads

Seroprevalence of Maternal and Cord Antibodies Specific for Diphtheria, Tetanus, Pertussis, Measles, Mumps and Rubella in Shunyi, Beijing.

Sci Rep 2018 Aug 29;8(1):13021. Epub 2018 Aug 29.

Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Maternal antibodies contribute to the protection of young infants from infectious diseases during the early life. However, vaccinations for women of child-bearing age are not routine in China. Therefore, we investigated the level of protective immunity against vaccine preventable diseases in pregnant women and newborns in China. Read More

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http://dx.doi.org/10.1038/s41598-018-31283-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115429PMC
August 2018
7 Reads
5.080 Impact Factor

[Prevalence of maternal measles, rubella, mumps and varicella antibodies in the first six months of life].

Mikrobiyol Bul 2018 Jul;52(3):324-327

Istanbul University Faculty of Medicine, Department of Medical Microbiology, Division of Virology and Basic Immunology, Istanbul, Turkey.

The protection of infants against infections during the first few months of life is provided mainly by maternal antibodies. The presence of maternal antibodies can decrease vaccine efficacy. The waning time of maternal antibodies shows variations therefore seroepidemiological studies are important for the development of vaccination schedules. Read More

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http://www.mikrobiyolbul.org/linkout.aspx?pmid=30156519
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http://dx.doi.org/10.5578/mb.67169DOI Listing
July 2018
17 Reads

Maintaining Concentration of Ribavirin in Cerebrospinal Fluid by a New Dosage Method; Three Cases of Subacute Sclerosing Panencephalitis Treated Using a Subcutaneous Continuous Infusion Pump.

Pediatr Infect Dis J 2018 Aug 27. Epub 2018 Aug 27.

Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.

Background: Subacute sclerosing panencephalitis (SSPE) is a slow virus infectious disease resulting from persistent infection with mutant measles virus. At present, there is no effective treatment for SSPE. Interferon-α and inosine pranobex have both been used for the treatment of SSPE, and partial success has been reported for the antiviral drug, ribavirin (RBV). Read More

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http://Insights.ovid.com/crossref?an=00006454-900000000-9655
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http://dx.doi.org/10.1097/INF.0000000000002181DOI Listing
August 2018
5 Reads

Usefulness of a systematic approach at listing for vaccine prevention in solid organ transplant candidates.

Am J Transplant 2019 Feb 12;19(2):512-521. Epub 2018 Oct 12.

Department of Pediatrics and Pathology-Immunology, Center for Vaccinology and Neonatal Immunology, Medical Faculty and University Hospitals of Geneva, Geneva, Switzerland.

Solid organ transplant (SOT) candidates may not be immune against potentially vaccine-preventable diseases because of insufficient immunizations and/or limited vaccine responses. We evaluated the impact on vaccine immunity at transplant of a systematic vaccinology workup at listing that included (1) pneumococcal with and without influenza immunization, (2) serology-based vaccine recommendations against measles, varicella, hepatitis B virus, hepatitis A virus, and tetanus, and (3) the documentation of vaccines and serology tests in a national electronic immunization registry (www.myvaccines. Read More

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http://dx.doi.org/10.1111/ajt.15097DOI Listing
February 2019
21 Reads

Risk factors for diagnosed noma in northwest Nigeria: A case-control study, 2017.

PLoS Negl Trop Dis 2018 08 23;12(8):e0006631. Epub 2018 Aug 23.

Public Health Department, Médecins Sans Frontières, Operation Centre Amsterdam, Amsterdam, The Netherlands.

Background: Noma (cancrum oris), a neglected tropical disease, rapidly disintegrates the hard and soft tissue of the face and leads to severe disfiguration and high mortality. The disease is poorly understood. We aimed to estimate risk factors for diagnosed noma to better guide existing prevention and treatment strategies using a case-control study design. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006631
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http://dx.doi.org/10.1371/journal.pntd.0006631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107110PMC
August 2018
16 Reads

IL28B, IL29 and micro-RNA 548 in subacute sclerosing panencephalitis as a rare disease.

Gene 2018 Dec 2;678:73-78. Epub 2018 Aug 2.

Faculty of Medicine, Department of Pediatrics, Bulent Ecevit University, Zonguldak, Turkey.

Subacute sclerosing panencephalitis (SSPE) is a progressive neurodegenerative disease which affects children and young adults, caused by a persistent infection of defective measles virus. IFN-λs (IL-28A, IL-28B and IL-29) are a group of cytokines mediating antiviral responses. It has been shown that IL-29 levels are significantly higher in infected cells with defective measles virus. Read More

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http://dx.doi.org/10.1016/j.gene.2018.07.062DOI Listing
December 2018
2 Reads

Recurrent invasive group A streptococcal infection with four-limb amputation in an immunocompetent child.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.

We report a previously well paediatric patient with two distinct presentations of invasive group A streptococcus (GAS) infection resulting in significant morbidity. The first episode, following GAS pharyngitis, involved multiorgan dysfunction syndrome. This included cardiorespiratory and acute hepatorenal failure and purpura fulminans that eventually necessitated four-limb amputation. Read More

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http://dx.doi.org/10.1136/bcr-2018-225292DOI Listing
July 2018
3 Reads

Pediatricians' vaccine attitudes and practices before and after a major measles outbreak.

J Child Health Care 2018 Jan 1:1367493518786011. Epub 2018 Jan 1.

3 Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA.

The objective of this study was to describe how a sample of pediatricians were impacted by and responded to the Disneyland measles outbreak in the United States. We conducted three repeated cross-sectional, online surveys in 2014 (before the outbreak), 2015, and 2016 (after the outbreak) among members of three state chapters of the American Academy of Pediatrics. We assessed pediatricians' level of willingness and length of time comfortable delaying the measles-mumps-rubella (MMR) vaccine before and after the outbreak. Read More

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http://dx.doi.org/10.1177/1367493518786011DOI Listing
January 2018
4 Reads

Vaccine wastage in The Gambia: a prospective observational study.

BMC Public Health 2018 Jul 11;18(1):864. Epub 2018 Jul 11.

Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia.

Background: Vaccination is a cost-effective and life-saving intervention. Recently several new, but more expensive vaccines have become part of immunization programmes in low and middle income countries (LMIC). Monitoring vaccine wastage helps to improve vaccine forecasting and minimise wastage. Read More

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http://dx.doi.org/10.1186/s12889-018-5762-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042329PMC
July 2018
14 Reads

Subacute sclerosing panencephalitis - current perspectives.

Pediatric Health Med Ther 2018 26;9:67-71. Epub 2018 Jun 26.

Department of Pediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan,

Subacute sclerosing panencephalitis is a progressive neurodegenerative disease. It usually occurs 7-10 years after measles infection. The clinical course is characterized by progressive cognitive decline and behavior changes followed by focal or generalized seizures as well as myoclonus, ataxia, visual disturbance, and later vegetative state, eventually leading to death. Read More

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http://dx.doi.org/10.2147/PHMT.S126293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027681PMC
June 2018
1 Read