1,851 results match your criteria Pediatrics Measles


Incidence and Risk Factors for Severe Pneumonia in Children Hospitalized with Pneumonia in Ujjain, India.

Int J Environ Res Public Health 2020 Jun 27;17(13). Epub 2020 Jun 27.

Department of Pediatrics, Ruxmaniben Deepchand Gardi Medical College, Ujjain 456006, Madhya Pradesh, India.

Childhood pneumonia is a major public health problem. The aim of this prospective hospital-based study is to determine the incidence and risk factors for community-acquired severe pneumonia in children in Ujjain, India. The study includes 270 children, 161 (60%) boys and 109 (40%) girls, aged between 2 months and 5 years with World Health Organization defined and radiologically confirmed severe pneumonia. Read More

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http://dx.doi.org/10.3390/ijerph17134637DOI Listing

A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant.

Cureus 2020 May 23;12(5):e8246. Epub 2020 May 23.

Paediatrics, Penteli Children's Hospital, Athens, GRC.

Measles continues to be a threat in most European countries due to suboptimum vaccination coverage. Although measles leads to several complications, measles-related hemophagocytic lymphohistiocytosis (HLH) has been rarely reported. Herein, we present a case of a four-month-old male infant, the first child of unrelated, healthy parents, with no significant medical history or unexplained infant death in the family, otherwise healthy, who was diagnosed with measles-associated HLH and was successfully treated with IV dexamethasone and IV immunoglobulin (IVIG). Read More

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http://dx.doi.org/10.7759/cureus.8246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308916PMC

Paediatrics in Theresienstadt ghetto.

Cent Eur J Public Health 2020 Jun;28(2):155-160

Faculty of Education, Comenius University, Bratislava, Slovak Republic.

The main objective of this study is to describe the most common childhood diseases occurring in the Theresienstadt ghetto during the Second World War as well as applied anti-epidemic measures. A partial objective is to describe medical and nursing care of sick child prisoners. The data was obtained by the method of synthesis of primary and secondary data with the highest importance after adequate external source criticism using selected monographs, memoirs, survivor diaries, Orders of the day by the Council of the Elders and Reports of the Jewish self-government of the Theresienstadt ghetto from 1941 to 1945, the Archives of the Jewish Museum in Prague, the Ghetto Museum, the Museum of the History of Polish Jews in Warsaw, Post Bellum online electronic collection of oral historical interviews, and witness accounts. Read More

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http://dx.doi.org/10.21101/cejph.a5557DOI Listing

Vaccine acceptance: How to build and maintain trust in immunization.

Can Commun Dis Rep 2020 May 7;46(5):155-159. Epub 2020 May 7.

Quebec National Institute of Public Health, Québec, QC.

In Canada, over 80% of parents choose to vaccinate their children. Although this may appear positive, it is one of the lowest vaccination rates in the western world, and does not meet the 95% coverage rate needed to prevent outbreaks of vaccine-preventable diseases such as measles. A recent national immunization survey showed approximately 50% of parents are concerned about potential side-effects from vaccines, 25% believe that a vaccine can cause the disease it was meant to prevent, and 13% think alternative practices could eliminate the need for vaccines. Read More

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http://dx.doi.org/10.14745/ccdr.v46i05a09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279131PMC

Routine vaccination during covid-19 pandemic response.

BMJ 2020 06 16;369:m2392. Epub 2020 Jun 16.

UCL Great Ormond Street Institute of Child Health, London, UK.

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http://dx.doi.org/10.1136/bmj.m2392DOI Listing

Investigating the etiologic agents of aseptic meningitis outbreak in Iranian children.

J Family Med Prim Care 2020 Mar 26;9(3):1573-1577. Epub 2020 Mar 26.

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Nemazi Hospital, Shiraz, Iran.

Introduction: This study aimed to determine the viral agent (s) and their genome burden associated with an aseptic meningitis outbreak that occurred in Yasuj, Iran.

Materials And Methods: During April to August 2015, 104 CSF samples from 104 patients under 14 years old admitted to the hospital of Yasuj, Iran, with aseptic meningitis associated clinical signs were collected. 200 μl CSF specimens was prepared for DNA and RNA viral genome extraction each and then subjected to diagnostic Taq-man real time PCR assays for the present of Enteroviruses, HSV, VZV, mumps, measles and rubella in the samples. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_1003_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266184PMC

School Nurses on the Front Lines of Healthcare: Infectious Diseases Popularized in the News.

NASN Sch Nurse 2020 Jul 3;35(4):212-216. Epub 2020 Jun 3.

Professor, Departments of Emergency Medicine and Pediatrics, Penn State College of Medicine, Attending Pediatric Emergency Medicine Physician, Penn State Hershey Medical Center, Hershey, PA.

School nurses may deal with students presenting with symptoms associated with infections popularized in the news. Although rare, the implications of missing or misdiagnosing these infections are potentially life-threatening and devastating. We present three students presenting with febrile illnesses associated with neurologic symptoms, a rash, and fatigue, focusing on the initial assessment and management of these students and their associated "hot topic" infection. Read More

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http://dx.doi.org/10.1177/1942602X20921426DOI Listing

Overview: The history and pediatric perspectives of severe acute respiratory syndromes: Novel or just like SARS.

Pediatr Pulmonol 2020 07 1;55(7):1584-1591. Epub 2020 Jun 1.

Division of Pediatric Pulmonology, Miller School of Medicine, University of Miami, Miami, Florida.

Many respiratory viral infections such as influenza and measles result in severe acute respiratory symptoms and epidemics. In the spring of 2003, an epidemic of coronavirus pneumonia spread from Guangzhou to Hong Kong and subsequently to the rest of the world. The WHO coined the acronym SARS (severe acute respiratory syndrome) and subsequently the causative virus as SARS-CoV. Read More

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http://dx.doi.org/10.1002/ppul.24810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301034PMC

Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection.

Cell 2020 05 4;181(5):969-977. Epub 2020 May 4.

Department of Medical Microbiology, University Medical Center Utrecht, University of Utrecht, the Netherlands.

SARS-CoV-2 infection is mild in the majority of individuals but progresses into severe pneumonia in a small proportion of patients. The increased susceptibility to severe disease in the elderly and individuals with co-morbidities argues for an initial defect in anti-viral host defense mechanisms. Long-term boosting of innate immune responses, also termed "trained immunity," by certain live vaccines (BCG, oral polio vaccine, measles) induces heterologous protection against infections through epigenetic, transcriptional, and functional reprogramming of innate immune cells. Read More

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http://dx.doi.org/10.1016/j.cell.2020.04.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196902PMC

A double-blind, randomized, multicenter, controlled study to evaluate the immunogenicity, safety, and tolerability of varicella vaccine (VARIVAX™) passage extension 34 (PE34) process administered concomitantly with measles, mumps, and rubella vaccine (M-M-R™ II).

Hum Vaccin Immunother 2020 May 19:1-7. Epub 2020 May 19.

Merck & Co., Inc., Kenilworth, NJ, USA.

The varicella vaccine passage extension (VAR-PE) process was undertaken to extend the availability of varicella zoster virus (VZV)-containing vaccines. This study (V210-A03; NCT03239873) assessed the immunogenicity, safety, and tolerability of VAR-PE process in comparison with varicella vaccine commercial product 2016 (VAR) randomized 1:1 in 600 healthy children 12 to 23 months of age administered concomitantly with measles-mumps-rubella (MMR) vaccine. The VZV seroconversion rate at 6 weeks Postdose 1 in the PP population was 100% for both groups. Read More

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http://dx.doi.org/10.1080/21645515.2020.1743122DOI Listing

Review of pediatric encephalitis and encephalopathy cases following immunization reported to the Canadian Immunization Monitoring Program Active (IMPACT) from 1992 to 2012.

Vaccine 2020 Jun 12;38(28):4457-4463. Epub 2020 May 12.

Department of Pediatrics, Dalhousie University and Canadian Center for Vaccinology, IWK Health Centre, Halifax, NS, Canada. Electronic address:

Background: Neurological adverse events following immunization (AEFI) remain poorly characterized. Our objective was to describe pediatric acute and chronic encephalopathy and encephalitis cases following immunization reported via active sentinel surveillance from 1992 to 2012.

Methods: This case series provides a descriptive analysis of encephalopathy/encephalitis admissions reported to the Canadian Immunization Monitoring Program ACTive (IMPACT). Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.04.035DOI Listing

Determinants of low uptake of vaccination against influenza, measles, and hepatitis B among healthcare professionals in Greece: a multicenter cross-sectional study.

Hum Vaccin Immunother 2020 May 13:1-7. Epub 2020 May 13.

Department of Paediatrics, Heraklion University Hospital, Heraklion, Greece.

Vaccination is recommended for healthcare professionals (HCPs) to protect them against vaccine-preventable diseases (VPDs); however, uptake rates are low. This study aimed to evaluate HCPs' influenza, hepatitis B, and measles vaccine uptake in all healthcare levels in Crete, Greece. We conducted a questionnaire-based, cross-sectional multicenter study in 2018, including HCPs employed at 18 primary care centers and 3 hospitals. Read More

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http://dx.doi.org/10.1080/21645515.2020.1741311DOI Listing

Anaphylaxis to MMR Vaccine Mediated by IgE Sensitivity to Gelatin.

Mil Med 2020 May 12. Epub 2020 May 12.

Allergy and Immunology, Wilford Hall Medical Center, 59th Medical Group, 2200 Bergquist Drive Lackland Air Force Base, San Antonio, TX 78236.

The measles-mumps-rubella (MMR) vaccine is generally well tolerated, and reports of anaphylaxis to the vaccine are rare. IgE-mediated reactions to vaccines are often caused by additives or residual vaccine components. An inability to obtain proper immunizations can be a disqualifying component to military service. Read More

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http://dx.doi.org/10.1093/milmed/usaa058DOI Listing

Measles, Malnutrition and Mortality: Puerto Rico, 1917-1918.

P R Health Sci J 2020 03;39(1):20-27

School of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, PR.

Objective: Recent measles outbreaks in the United States and Europe have highlighted the threat of the disease. We studied the 1917-1918 epidemic in Puerto Rico to better understand the social and place-specific risk factors and severity of such crises.

Methods: We reviewed medical and government reports, newspapers and private contemporary documents. Read More

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Measles: taking steps forward to prevent going backwards.

Curr Opin Pediatr 2020 Jun;32(3):436-445

Division of Pediatric Emergency Medicine, Cohen Children's Medical Center, Queens, New York, USA.

Purpose Of Review: The measles vaccine, first introduced in 1963, directly led to a dramatic decrease in the incidence of the disease. Measles transitioned from being a common childhood disease, affecting approximately three to four million children annually, to being eradicated in the United States in 2000. What was once an astounding victory for modern medicine, however, has recently seen a dramatic reversal in fortune, with a resurgence of measles cases in the United States. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000895DOI Listing

Control of measles in a juvenile custodial setting in the wake of the recent US outbreak.

Pan Afr Med J 2020 3;35(Suppl 1). Epub 2020 Jan 3.

Department of Pediatrics, John H Stroger Hospital of Cook County, Chicago, Illinois, United States.

The recent US measles outbreak is the largest since 1992. It is just a matter of time before measles is introduced into a juvenile custodial setting. Are we prepared? Should we be prepared? This short article addresses steps institutional settings should take to prevent the spread of measles in a contained setting. Read More

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http://dx.doi.org/10.11604/pamj.supp.2020.35.1.20172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195918PMC
January 2020

Antibodies to measles, mumps, and rubella virus in Thai children after two-dose vaccination at 9 months and 2.5 years: A longitudinal study.

Vaccine 2020 May 21;38(24):4016-4023. Epub 2020 Apr 21.

Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Academy of Science, Royal Society of Thailand, Bangkok, Thailand. Electronic address:

Introduction: Thailand changed the schedule of childhood measles-mumps-rubella (MMR) vaccination in 2014, moving the second dose from the age of 6 years to 2.5 years. There are currently no data on antibody responses to the MMR vaccine since this recommendation. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.04.013DOI Listing

Seroprevalences of antibodies against pertussis, diphtheria, tetanus, measles, mumps and rubella: A cross-sectional study in children following vaccination procedure in Guangzhou, China.

Vaccine 2020 May 19;38(23):3960-3967. Epub 2020 Apr 19.

Department of Pediatrics, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China. Electronic address:

This study investigated the concentrations and seroprevalence of immunoglobulin G (IgG) antibodies against pertussis, diphtheria, tetanus, measles, mumps and rubella among children in Guangzhou, China. We conducted a cross-sectional study focusing on the post-vaccination immune statuses of children on scheduled immunisation. Human IgG antibody against six diseases were measured using commercial enzyme-linked immunosorbent assay kits. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.03.056DOI Listing

Juvenile Paget's Disease From Heterozygous Mutation of SP7 Encoding Osterix (Specificity Protein 7, Transcription Factor SP7).

Bone 2020 Apr 13;137:115364. Epub 2020 Apr 13.

Center For Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110, USA; Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

Juvenile Paget's disease (JPD) became in 1974 the commonly used name for ultra-rare heritable occurrences of rapid bone remodeling throughout of the skeleton that present in infancy or early childhood as fractures and deformity hallmarked biochemically by marked elevation of serum alkaline phosphatase (ALP) activity (hyperphosphatasemia). Untreated, JPD can kill during childhood or young adult life. In 2002, we reported that homozygous deletion of the gene called tumor necrosis factor receptor superfamily, member 11B (TNFRSF11B) encoding osteoprotegerin (OPG) explained JPD in Navajos. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115364DOI Listing

Paediatric respiratory isolation: A challenge for a secondary care hospital! A service innovation project.

J Pak Med Assoc 2020 Apr;70(4):660-666

Department of Pediatrics, Child life Foundation, Karachi, Pakistan.

Objective: The aim of this project was to broaden the secondary care hospital's scope of services and provide safe, effective and quality care for the patient presenting with measles.

Methods: Six Sigma DMAIC [define measure, analyze, improve, and control (DMAIC)] methodology was used in this quality improvement project. The quality project was started in October 2015 using a Gantt chart quality tool. Read More

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http://dx.doi.org/10.5455/JPMA.20647DOI Listing
April 2020
0.403 Impact Factor

Childhood vaccination coverage and equity impact in Ethiopia by socioeconomic, geographic, maternal, and child characteristics.

Vaccine 2020 Apr 3;38(20):3627-3638. Epub 2020 Apr 3.

Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, United Kingdom. Electronic address:

Background: Ethiopia is a priority country of Gavi, the Vaccine Alliance to improve vaccination coverage and equitable uptake. The Ethiopian National Expanded Programme on Immunisation (EPI) and the Global Vaccine Action Plan set coverage goals of 90% at national level and 80% at district level by 2020. This study analyses full vaccination coverage among children in Ethiopia and estimates the equity impact by socioeconomic, geographic, maternal and child characteristics based on the 2016 Ethiopia Demographic and Health Survey dataset. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.03.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171468PMC

Review of Measles in Korea: Quarantine and Elimination.

Authors:
Jin Han Kang

Infect Chemother 2020 Mar;52(1):113-122

Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Strong policies were established to maintain vaccination rate at ≥95% to expedite the eradication and elimination of measles outbreaks; nationwide survey of measles immunity to determine the susceptibility and the mandatory submission of second measles vaccination records when entering primary school. The measles control policies were also implemented to help achieve the goal of eliminating measles after the catch-up vaccination and they can be summarized as strategies for classifying measles patients based on their clinical symptoms while anticipating that weaker symptoms than those in typical cases would be seen; improving the operation of laboratories to world-class level for diagnosis of measles and identification of epidemiological circumstances for strengthen the detection of patients suspected of having measles; and immediate response through a rapid reporting system. With these efforts, Korea became the country to make the declaration of measles elimination by complying with all standards presented by the World Health Organization in 2006, re-verified in 2014. Read More

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http://dx.doi.org/10.3947/ic.2020.52.1.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113451PMC

Utility of enzyme immunoassays to diagnose subacute sclerosing panencephalitis.

Pediatr Int 2020 Apr 2. Epub 2020 Apr 2.

Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Fukushima, Japan.

Background: Subacute sclerosing panencephalitis (SSPE) is a progressive neurologic disorder caused by the measles virus (MV) and is identified by positive MV-specific antibody titers detected mainly by hemagglutination inhibition (HI) tests in the cerebrospinal fluid (CSF). However, an alternative method, the enzyme immunoassay (EIA), has become an increasingly preferred method for detecting MV antibodies. To establish the index for SSPE diagnosis using EIA, we investigated the correlation between HI and EIA titers of MV antibodies in SSPE patients. Read More

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http://dx.doi.org/10.1111/ped.14244DOI Listing

[Coverage rate and adverse reactions of National Immunization Program vaccines in children with spinal muscular atrophy: a cross-sectional retrospective cohort study].

Zhonghua Er Ke Za Zhi 2020 Apr;58(4):308-313

Department of Medical Genetics, Capital Institute of Pediatrics, Beijing 100020, China.

To investigate the coverage rate and the adverse reactions of National Immunization Program vaccines in children with spinal muscular atrophy (SMA). A cross-sectional retrospective cohort study was carried out from July 2016 to June 2019, 192 children (116 boys and 76 girls) with SMA registered by Capital Institute of Pediatrics and 191 healthy children (115 boys and 76 girls) vaccinated in Chaoyang Olympic Village Community Health Service Center from July 2016 to December 2018 were included. Questionnaire survey was designed to investigate the vaccination coverage rate and associated adverse events. Read More

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http://dx.doi.org/10.3760/cma.j.cn112140-20200108-00016DOI Listing

A live-vaccine-last schedule: saving an extra million lives a year?

Authors:
Frank Shann

Clin Infect Dis 2020 Mar 18. Epub 2020 Mar 18.

Department of Paediatrics, University of Melbourne, Australia.

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http://dx.doi.org/10.1093/cid/ciaa292DOI Listing

The History of the Personal Belief Exemption.

Authors:
Elena Conis

Pediatrics 2020 04 17;145(4). Epub 2020 Mar 17.

Graduate School of Journalism and Center for Science, Technology, Medicine, and Society, University of California, Berkeley, Berkeley, California; and Department of Anthropology, History, and Social Medicine, University of California, San Francisco, San Francisco, California

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http://dx.doi.org/10.1542/peds.2019-2551DOI Listing

Transcriptomic profiling of different responder types in adults after a Priorix® vaccination.

Vaccine 2020 Apr 9;38(16):3218-3226. Epub 2020 Mar 9.

AUDACIS, Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing, University of Antwerp, Antwerp, Belgium; Centre for the Evaluation of Vaccination (CEV), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.

Thanks to the recommendation of a combined Measles/Mumps/Rubella (MMR) vaccine, like Priorix®, these childhood diseases are less common now. This is beneficial to limit the spread of these diseases and work towards their elimination. However, the measles, mumps and rubella antibody titers show a large variability in short- and long-term immunity. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.03.004DOI Listing

The nucleic acid positive rate and genotype distribution of human cytomegalovirus in human milk banks in China.

Arch Virol 2020 May 9;165(5):1099-1107. Epub 2020 Mar 9.

Medical School, Anhui University of Science and Technology, Huainan, 232001, Anhui, People's Republic of China.

To determine the status of human cytomegalovirus (HCMV) infection in human milk in China, a total of 510 human milk samples obtained from three provinces, including 211 donor human milk samples from human milk banks and 299 milk samples obtained from the mothers of premature infants, were tested to detect HCMV DNA. Overall, 46.4% of the donated milk samples and 59. Read More

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http://dx.doi.org/10.1007/s00705-020-04573-yDOI Listing

An outbreak of measles in gold miners in River Nile State, Sudan, 2011.

East Mediterr Health J 2020 Feb 24;26(2):152-160. Epub 2020 Feb 24.

Department of Medicine and HIV Metabolic Clinic, Milton Keynes University Hospital NHS, Foundation Trust, Eaglestone, Milton Keynes, United Kingdom.

Background: Despite the wide use of vaccination, measles outbreaks still occur.

Aims: This study assessed cases notified during a measles outbreak in northern Sudan in 2011 and the response of the health authorities to contain the outbreak.

Methods: The records of all measles cases reported to the River Nile State health ministry in 2011 from the Abu Hamad locality, a gold-mining area, were reviewed together with the actions of the health authorities at the time of the outbreak. Read More

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http://dx.doi.org/10.26719/2020.26.2.152DOI Listing
February 2020

A Case of Anaphylaxis to Measles Vaccination in an Infant with Cow's Milk Allergy.

Pediatr Allergy Immunol Pulmonol 2019 Sep 17;32(3):135-138. Epub 2019 Sep 17.

Division of Pediatric Allergy and Immunology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Cow's milk is one of the most common of the foods that cause food allergies in children. Here, we present a 10-month-old male who was diagnosed with having an allergy to cow's milk and who developed an anaphylactic reaction after being recently vaccinated with a measles vaccine. The patient had been diagnosed with atopic dermatitis and cow's milk allergy at 40 days old after a rash appeared on his face and arms while exclusively breastfeeding. Read More

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http://dx.doi.org/10.1089/ped.2019.0993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057048PMC
September 2019

Epidemiological investigation and containment of a measles outbreak in New York: Critical appraisal and public health implications for India.

Authors:
Joseph L Mathew

Natl Med J India 2019 May-Jun;32(3):153-155

Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.4103/0970-258X.278690DOI Listing

Combating vaccine hesitancy and other 21st century social determinants in the global fight against measles.

Curr Opin Virol 2020 Feb 26;41:1-7. Epub 2020 Feb 26.

Department of Health Promotion & Community Health Sciences, Texas A&M School of Public Health, College Station, Texas, USA. Electronic address:

The year 2019 marked the return of measles after almost two decades of unprecedented successes in global vaccination programs. Measles transmission due to sharp declines in measles-mumps-rubella (MMR) vaccination coverage is now widespread among nations that previously saw impressive public health gains including Philippines, DR Congo, Madagascar, Samoa, many in Europe, and the United States and Venezuela in the Americas. Key determinants include the interruption of vaccine health systems due to war, conflict, and political instability; food insecurity and urbanization; and an increasingly globalized vaccine hesitancy or antivaccine movement. Read More

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http://dx.doi.org/10.1016/j.coviro.2020.01.001DOI Listing
February 2020

The factors relevant to partial remission in children with type 1 diabetes mellitus after measles vaccination: A retrospective study.

J Med Virol 2020 Feb 28. Epub 2020 Feb 28.

Department of Pediatric Endocrinology and Metabolism, Istanbul Medipol University, Istanbul, Turkey.

We aimed to identify the determinants of partial remission in patients with type 1 diabetes mellitus (DM), and whether there is an influence of vaccination against measles on partial remission. This was a retrospective study consisting of consecutive patients diagnosed with type 1 DM followed-up from 1 September 2010, through 30 November 2011. The study included children vaccinated within 3 months after diagnosis, and children unvaccinated during the first 12 months of the disease. Read More

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http://dx.doi.org/10.1002/jmv.25734DOI Listing
February 2020

Healthcare Workers' Preparedness: An Exploratory Study for Measles Control in a Middle-Income Country.

Infect Drug Resist 2020 10;13:395-402. Epub 2020 Feb 10.

Medical Microbiology & Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background: Healthcare workers (HCWs) should have an active role in measles control.

Objective: This study aimed to assess the HCWs' measles immune status and its influencing factors; to measure their knowledge, attitude, and practice toward measles infection/vaccination; and to identify factors predicting their vaccination status.

Methods: Data were collected using a semi-tailored questionnaire. Read More

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http://dx.doi.org/10.2147/IDR.S234378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021916PMC
February 2020

What was the real cause of the dramatic increase in measles mortality during the 2015/2016 Mongolian Outbreak?

J Infect Dis 2020 Feb 27. Epub 2020 Feb 27.

New Vaccines Group, Murdoch Children's Research Institute, Melbourne, Australia.

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http://dx.doi.org/10.1093/infdis/jiaa084DOI Listing
February 2020

Increasing incidence of subacute sclerosing panencephalitis in infants: a collateral effect of under-vaccination.

Clin Microbiol Infect 2020 Jun 20;26(6):662-664. Epub 2020 Feb 20.

Paediatric Infectious Diseases Unit, Division of General Paediatrics, Department of Paediatrics, Gynaecology & Obstetrics, University Hospitals of Geneva & University of Geneva's Faculty of Medicine, 6 Rue Willy Donzé, 1211 Geneva, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cmi.2020.02.014DOI Listing

Recent advances of oncolytic virus in cancer therapy.

Hum Vaccin Immunother 2020 Feb 20:1-14. Epub 2020 Feb 20.

Vaccine Research Center, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.

Oncolytic viruses have been taking the front stage in biological therapy for cancer recently. The first and most potent virus to be used in oncolytic virotherapy is human adenovirus. Recently, ongoing extensive research has suggested that other viruses like herpes simplex virus (HSV) and measles virus can also be considered as potential candidates in cancer therapy. Read More

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http://dx.doi.org/10.1080/21645515.2020.1723363DOI Listing
February 2020

Neutrophil/Lymphocyte Ratios, Platelet/Lymphocyte Ratios, and Mean Platelet Volume Values in Patients with Measles.

Cureus 2020 Jan 9;12(1):e6607. Epub 2020 Jan 9.

Pediatrics, Harran University, Şanlıurfa, TUR.

Aim: The purpose of this study was to compare neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV) values of patients with measles within the healthy control group and then determine the utility of these parameters for determination of inflammatory situation in patients with measles.

Materials And Method: A total of 51 pediatric patients who had visited Harran University Medical Faculty Pediatrics Clinic between June 2018 and May 2019 and who had been diagnosed with measles after anamnesis, clinical, and serological evaluations were included our study; 49 healthy children who visited our clinic for various reasons and had taken hemogram tests were also added to our study as the control group.

Results: NLR and PLR values were observed higher than the control group for patients diagnosed with measles; however, the difference between the two groups was not statistically significant (p values 0. Read More

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http://dx.doi.org/10.7759/cureus.6607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008753PMC
January 2020

Update from the Advisory Committee on Immunization Practices.

J Pediatric Infect Dis Soc 2020 Feb;9(1):3-5

Department of Pediatrics, University of Alabama at Birmingham.

The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. There are usually 15 voting members; members' terms are for 4 years. ACIP members and Centers for Disease Control and Prevention staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and results from clinical trials. Read More

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http://dx.doi.org/10.1093/jpids/piaa008DOI Listing
February 2020

Vaccination coverage of general practitioners: a cross-sectional study from Greece.

Public Health 2020 Apr 27;181:110-113. Epub 2020 Jan 27.

Clinic of Social and Family Medicine, School of Medicine, University of Crete, Heraklion, 71003, Greece. Electronic address:

Objectives: Vaccination coverage of general practitioners (GPs) is important for their own and for their colleagues' and patients' protection and has been associated with the coverage of the general population. Our study aims to evaluate the vaccination practices of GPs in Crete, Greece.

Study Design: Cross-sectional, questionnaire-based survey. Read More

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http://dx.doi.org/10.1016/j.puhe.2019.12.012DOI Listing

Comparison of the Seroprevalence of Measles Antibodies among Healthcare Workers in Two Korean Hospitals in 2019.

Infect Chemother 2020 Mar 21;52(1):93-97. Epub 2020 Jan 21.

Department of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea.

We performed a point seroprevalence survey of measles among healthcare workers (HCWs) at two Korean teaching hospitals in 2019. A total of 2,830 HCWs underwent an antibody test. The overall seropositivity of measles was 93. Read More

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http://dx.doi.org/10.3947/ic.2020.52.1.93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113453PMC

Measles recognition during measles outbreak at a paediatric university hospital, Austria, January to February 2017.

Euro Surveill 2020 Jan;25(3)

Department of General Paediatrics, Medical University of Graz, Graz, Austria.

Recognition of measles is crucial to prevent transmissions in the hospital settings. Little is known about the level of recognition of measles and possible causes of not recognising the disease by physicians in the post-vaccine era. We report on a measles outbreak in a paediatric hospital in Austria in January to February 2017 with strikingly high numbers of not recognised cases. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2020.25.3.1900260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988273PMC
January 2020

Live attenuated MMR/V booster vaccines in children with rheumatic diseases on immunosuppressive therapy are safe: Multicenter, retrospective data collection.

Vaccine 2020 Feb 24;38(9):2198-2201. Epub 2020 Jan 24.

Department of Allergology, Rheumatology and Clinical Immunology, University Children's Hospital, University Medical Centre Ljubljana, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Purpose: To collect retrospective data of patients with Juvenile Idiopathic Arthritis (JIA) and other rheumatic diseases who received live attenuated booster measles-mumps-rubella (MMR) or measles-mumps-rubella-varicella (MMR/V) during treatment with immunosuppressive therapy.

Results: Data from 13 pediatric rheumatology centers in 10 countries, including 234 patients, were collected. Mean age at diagnosis was 5 ± 2. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.01.037DOI Listing
February 2020

Diagnosing inborn error of immunity following the presentation of a complicated acquired infection after MMRV vaccine administration.

BMJ Case Rep 2020 Jan 21;13(1). Epub 2020 Jan 21.

Paediatric Critical Care Medicine, Shaikh Khalifa Medical City, Abu Dhabi, United Arab Emirates

Live vaccine-acquired infection should attest for the occurrence of inborn errors of immunity. Autosomal recessive immunodeficiency 31B, a result of a signal transducer and activator of transcription 1 genetic mutation, results in defected interferon pathways: interferon alpha/beta and interferon gamma. These interferons are crucial for the defence against viral and mycobacterial infections. Read More

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http://dx.doi.org/10.1136/bcr-2019-233063DOI Listing
January 2020

Vaccination Programs for Adults in Europe, 2019.

Vaccines (Basel) 2020 Jan 20;8(1). Epub 2020 Jan 20.

Department for Interventions in Health Care Facilities, National Organization of Public Health, 15123 Athens, Greece.

Background: While all European countries implement vaccination programs for children, there are gaps in terms of vaccination programs for adults.

Methods: We studied the 2019 vaccination policies for adults in 42 European countries.

Results: Vaccination programs for adults were in place in all countries. Read More

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http://dx.doi.org/10.3390/vaccines8010034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157239PMC
January 2020

Family Health Days program contributions in vaccination of unreached and under-immunized children during routine vaccinations in Uganda.

PLoS One 2020 17;15(1):e0218239. Epub 2020 Jan 17.

Health Manager, UNICEF Jordan Country Office, Amman, Jordan.

Background: We explored the contributions of the Family Health Days (FHDs) concept, which was developed by the Uganda Ministry of Health (MOH) and UNICEF as a supplementary quarterly outreach program in addition to strengthening the routine expanded program for immunization (EPI), with the aim to increase coverage, through improved access to the unimmunized or unreached and under-immunized children under 5 years.

Method: A cross-sectional descriptive study of the Uganda MOH, Health Management Information Systems (HMIS) and UNICEF in house FHDs data was conducted covering six quarterly implementations of the program between April 2012 and December 2013. The FHDs program was implemented in 31 priority districts with low routine vaccination coverage from seven sub-regions in Uganda in a phased manner using places of worship for service delivery. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218239PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968838PMC

Mandatory Vaccination in Europe.

Pediatrics 2020 02 13;145(2). Epub 2020 Jan 13.

Departments of Epidemiology and.

Background: Mandatory vaccination has been effective in maintaining high vaccination coverage in countries such as the United States. However, there are no peer-reviewed analyses of the association between mandates and both coverage and subsequent incidence of vaccine-preventable disease in Europe.

Methods: Using data from the European Centre for Disease Prevention and Control and the World Health Organization, we evaluated the relationship between country-level mandatory vaccination policies and (1) measles and pertussis vaccine coverage and (2) the annual incidence of these diseases in 29 European countries. Read More

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http://dx.doi.org/10.1542/peds.2019-0620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011108PMC
February 2020

Identification of Viral Signatures Using High-Throughput Sequencing on Blood of Patients With Kawasaki Disease.

Front Pediatr 2019 19;7:524. Epub 2019 Dec 19.

Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva & Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Kawasaki disease is an acute pediatric vasculitis whose etiology remains unknown but epidemiology and clinical presentation suggest a viral etiology. We performed unbiased high-throughput-sequencing on blood of patients with Kawasaki Disease (KD). High-throughput-sequencing was performed directly on blood of children with typical KD. Read More

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http://dx.doi.org/10.3389/fped.2019.00524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930886PMC
December 2019

Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector.

Front Immunol 2019 16;10:2873. Epub 2019 Dec 16.

Department of Microbiology, Infectiology and Immunology, University of Montréal, Montréal, QC, Canada.

NK-cell resistance to transduction is a major technical hurdle for developing NK-cell immunotherapy. By using Baboon envelope pseudotyped lentiviral vectors (BaEV-LVs) encoding eGFP, we obtained a transduction rate of 23.0 ± 6. Read More

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http://dx.doi.org/10.3389/fimmu.2019.02873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927467PMC
December 2019

Worldwide Measles Epidemic Response.

Mo Med 2019 Nov-Dec;116(6):480

Infectious Diseases and Pediatrics, Children's Mercy Kansas City.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913846PMC
February 2020