2,119 results match your criteria Pediatrics Measles


Beware of α-lactalbumin as a hidden allergen in measles, mumps, and rubella vaccine in the patients with cow's milk allergy.

Pediatr Allergy Immunol 2022 06;33(6)

Division of Pediatrics, Department of Pediatric Allergy and Immunology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

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Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds.

Viruses 2022 May 29;14(6). Epub 2022 May 29.

Department of Viroscience, Erasmus MC, 3015 GD Rotterdam, The Netherlands.

Measles virus (MV) is a highly contagious respiratory virus responsible for outbreaks associated with significant morbidity and mortality among children and young adults. Although safe and effective measles vaccines are available, the COVID-19 pandemic has resulted in vaccination coverage gaps that may lead to the resurgence of measles when restrictions are lifted. This puts individuals who cannot be vaccinated, such as young infants and immunocompromised individuals, at risk. Read More

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EULAR/PRES recommendations for vaccination of paediatric patients with autoimmune inflammatory rheumatic diseases: update 2021.

Ann Rheum Dis 2022 Jun 20. Epub 2022 Jun 20.

RITA, European Reference Networks, Brussels, Belgium.

Objectives: Recent insights supporting the safety of live-attenuated vaccines and novel studies on the immunogenicity of vaccinations in the era of biological disease-modifying antirheumatic drugs in paediatric patients with autoimmune/inflammatory rheumatic diseases (pedAIIRD) necessitated updating the EULAR recommendations.

Methods: Recommendations were developed using the EULAR standard operating procedures. Two international expert committees were formed to update the vaccination recommendations for both paediatric and adult patients with AIIRD. Read More

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Trends and outcomes of admissions in the Paediatrics ward at a tertiary care hospital of urban Karachi.

J Pak Med Assoc 2022 May;72(5):954-957

Department of Paediatrics, Bahria University Medical and Dental College, Karachi, Pakistan.

In order to improve the health care system in Pakistan, the first step is to assess which diseases are the most prevalent and to what extent among children and lead to hospital admissions. This would help to improve the facilities and management and thus reduce the duration of hospital stay. This study aimed to determine the spectrum of disease presentation and the outcome and duration of hospital stay of patients presenting to the paediatric ward of a tertiary care hospital. Read More

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Risk factors associated with non-vaccination in Gambian children: a population-based cohort study.

Trans R Soc Trop Med Hyg 2022 Jun 13. Epub 2022 Jun 13.

MRC Unit The Gambia at LSHTM, Fajara, 00000, The Gambia.

Background: We determined the risk factors associated with unvaccinated children in rural Gambia.

Methods: We conducted prospective demographic surveillance and recorded immunisations in real time in the Upper River Region, The Gambia. Analysis included residents born from 1 January 2012 to 31 December 2016. Read More

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Immunogenicity after outbreak response immunization activities among young healthcare workers with secondary vaccine failure during the measles epidemic in Korea, 2019.

BMC Infect Dis 2022 Jun 8;22(1):530. Epub 2022 Jun 8.

Division of Infectious Diseases, Department of Medicine, Korea University Ansan Hospital, Korea University College of Medicine, 123 Jeokgeum-ro, Danwon-gu, 15355, Ansan, Republic of Korea.

Background: Despite high vaccination coverage, measles outbreaks have been reported in measles elimination countries, especially among healthcare workers in their 20 and 30 s. This study was designed to identify measles-susceptible individuals and to evaluate whether primary or secondary vaccine failure occurred during measles outbreak response immunization (ORI) activities.

Methods: The study population was divided into three groups as follows: natural immunity group (Group 1), vaccine-induced immunity group (Group 2), and vaccine failure group (Group 3). Read More

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Measles seroprevalence in Thailand: are adolescents and young adults at risk of measles?

Singapore Med J 2022 Jun 2. Epub 2022 Jun 2.

Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand.

Introduction: During the last decade, measles has become an important re-emerging disease in Thailand. The objective of this study was to measure measles seroprevalence and its influencing factors and to plan for an improved vaccination program.

Methods: A total of 600 participants aged between 9 months and 50 years were divided into seven groups those represent birth cohorts that experienced different measles vaccination policies. Read More

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Immunisation status of UK-bound refugees between January, 2018, and October, 2019: a retrospective, population-based cross-sectional study.

Lancet Public Health 2022 May 27. Epub 2022 May 27.

Migrant Health Research Group, Institute for Infection and Immunity, St George's, University of London, London, UK. Electronic address:

Background: WHO's new Immunization Agenda 2030 places a focus on ensuring migrants and other marginalised groups are offered catch-up vaccinations across the life-course. Yet, it is not known to what extent specific groups, such as refugees, are immunised according to host country schedules, and the implications for policy and practice. We aimed to assess the immunisation coverage of UK-bound refugees undergoing International Organization for Migration (IOM) health assessments through UK resettlement schemes, and calculate risk factors for under-immunisation. Read More

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The measles, mumps, rubella, varicella vaccination was safe in children with acute egg food protein-induced enterocolitis syndrome but anxiety was high.

Acta Paediatr 2022 May 17. Epub 2022 May 17.

Department of Life Sciences and Public Health, Pediatric Allergy Unit, Pediatrics Section, Policlinico Gemelli Universitary Foundation IRCCS, Catholic University of Sacre Hearth, Rome, Italy.

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Low post-transplant measles and varicella titers among pediatric liver transplant recipients: A 10-year single-center study.

Pediatr Transplant 2022 May 17:e14322. Epub 2022 May 17.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Mattel Children's Hospital at UCLA Medical Center, Los Angeles, California, USA.

Background: Vaccine preventable illnesses are important sources of morbidity, mortality, and increased healthcare costs in pediatric LT recipients. Our aim was to measure the seroprevalence of antibodies to measles and VZV in this population.

Methods: We conducted a retrospective chart review of 44 patients who received LT before age 18 at UCLA Mattel Children's Hospital from January 2008 to December 2017. Read More

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Influence of measles-mumps-rubella vaccine series initiation and completion on influenza vaccination among adolescents.

Int J Pediatr Adolesc Med 2022 Mar 4;9(1):11-15. Epub 2020 Dec 4.

Department of Pediatrics, Brody School of Medicine, East Carolina University, Greenville, NC, USA.

Background: Influenza vaccine participation in adolescents is low. Barriers to the influenza vaccine may be shared with the measles-mumps-rubella (MMR) vaccine.

Methods: We studied adolescents aged 13-17 years who participated in the National Immunization Survey-Teen between 2011 and 2017 (N = 129,200). Read More

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Update on the Coordinated Efforts of Looking After the Health Care Needs of Children and Young People Fleeing the Conflict Zone of Ukraine Presenting to European Emergency Departments-A Joint Statement of the European Society for Emergency Paediatrics and the European Academy of Paediatrics.

Front Pediatr 2022 26;10:897803. Epub 2022 Apr 26.

Paediatric Emergency Department, Hopital Universitaire Robert-Debre, Paris, France.

This joint statement by the European Society for Emergency Paediatrics and European Academy of Paediatrics aims to highlight recommendations for dealing with refugee children and young people fleeing the Ukrainian war when presenting to emergency departments (EDs) across Europe. Children and young people might present, sometimes unaccompanied, with either ongoing complex health needs or illnesses, mental health issues, and injuries related to the war itself and the flight from it. Obstacles to providing urgent and emergency care include lack of clinical guidelines, language barriers, and lack of insight in previous medical history. Read More

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Interventions for High-Burden Infectious Diseases in Children and Adolescents: A Meta-analysis.

Pediatrics 2022 05;149(Suppl 5)

Institute of Global Health and Development, Aga Khan University, Karachi, Pakistan.

Background: Approximately 2.2 million deaths were reported among school-age children and young people in 2019, and infectious diseases remain the leading causes of morbidity and mortality, especially in low and middle-income countries. We aim to synthesize evidence on interventions for high-burden infectious diseases among children and adolescents aged 5 to 19 years. Read More

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Population immunity to measles in Canada using Canadian Health Measures survey data - A Canadian Immunization Research Network (CIRN) study.

Vaccine 2022 May 28;40(23):3228-3235. Epub 2022 Apr 28.

Public Health Ontario, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Centre for Vaccine Preventable Diseases, University of Toronto, Canada. Electronic address:

We aimed to determine population immunity to measles in Canada, and to assess the risk of future outbreaks. We tested 11,176 sera from Cycles 2 (2009-2011) and 3 (2011-2013) cohorts from the biobank of Statistics Canada's Canadian Health Measures Survey (CHMS) using the BioPlex 2220 MMRV IgG assay. We then tested all BioPlex negative and equivocal samples using a more sensitive Plaque Reduction Neutralization Test (PRNT). Read More

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Parental and provider vaccine hesitancy and non-timely childhood vaccination in Switzerland.

Vaccine 2022 May 26;40(23):3193-3202. Epub 2022 Apr 26.

University of Basel, Basel, Switzerland; University Department of Medicine, Kantonsspital Baselland, Bruderholz, Switzerland. Electronic address:

Objective: Although medical providers are a trusted vaccination information source for parents, they do not universally support vaccination. Complementary medicine (CM) providers are particularly likely to hold vaccine hesitant (VH) views, and VH parents often consult with them. Little research compares VH of parents and providers, and if and how each is associated with uptake of recommended childhood vaccines. Read More

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Clinical advances in oncolytic virotherapy for pediatric brain tumors.

Pharmacol Ther 2022 Apr 26;239:108193. Epub 2022 Apr 26.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:

Malignant brain tumors constitute nearly one-third of cancer diagnoses in children and have recently surpassed hematologic malignancies as the most lethal neoplasm in the pediatric population. Outcomes for children with brain tumors are unacceptably poor and current standards of care-surgical resection, chemotherapy, and radiation-are associated with significant long-term morbidity. Oncolytic virotherapy has emerged as a promising immunotherapy for the treatment of brain tumors. Read More

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Poor Uptake of MMR Vaccine 1-year Post-Measles Outbreak: New York City and Israel.

J Pediatric Infect Dis Soc 2022 Apr 27. Epub 2022 Apr 27.

Department of Pediatrics, Division of Pediatric Infectious Diseases, New York University Grossman School of Medicine, New York, New York, USA.

Background: In 2018-2019, large outbreaks of measles occurred in Israel and in New York City, driven in part by travel of unimmunized children between the 2 communities.

Methods: A retrospective chart review was conducted for children tested for measles (March 2018-September 2019) at NYU Langone Health in New York, NY, and in Ramla subdistrict, Israel. Vaccination records were reviewed to determine vaccination status for measles, mumps, and rubella (MMR) at the time of measles testing and 1-year post-testing. Read More

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Does mothers' and caregivers' access to information on their child's vaccination card impact the timing of their child's measles vaccination in Uganda?

BMC Public Health 2022 04 26;22(1):834. Epub 2022 Apr 26.

Child Health and Development Centre, School of Medicine, Makerere University, Kampala, Uganda.

Introduction: On-time measles vaccination is essential for preventing measles infection among children as early in life as possible, especially in areas where measles outbreaks occur frequently. Characterizing the timing of routine measles vaccination (MCV1) among children and identifying risk factors for delayed measles vaccination is important for addressing barriers to recommended childhood vaccination and increasing on-time MCV1 coverage. We aim to assess the timing of children's MCV1 vaccination and to investigate the association between demographic and healthcare factors, mothers'/caregivers' ability to identify information on their child's vaccination card, and achieving on-time (vs. Read More

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Systematic review of health and disease in Ukrainian children highlights poor child health and challenges for those treating refugees.

Acta Paediatr 2022 Jul 27;111(7):1341-1353. Epub 2022 Apr 27.

Department of Paediatrics, Academic and Research Medical Institute, Sumy State University, Sumy, Ukraine.

Aim: Millions of Ukrainian children have been internally displaced or fled to other countries because of the Russian war. This systematic review focused on their health needs and future challenges for clinicians.

Methods: A systematic literature search of the Medline, Embase and MedRxiv databases from 1 January 2010 to 31 March 2022 identified 1628 papers on the health of Ukrainian children and 112 were relevant to this review. Read More

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Subacute Sclerosing Panencephalitis in Children: The Archetype of Non-Vaccination.

Viruses 2022 03 31;14(4). Epub 2022 Mar 31.

National Measles Reference Laboratory-WHO/LabNet, Department of Infectious Diseases-Istituto Superiore di Sanità (ISS), 00165 Rome, Italy.

Subacute sclerosing panencephalitis (SSPE) is a late complication of measles virus infection that occurs in previously healthy children. This disease has no specific cure and is associated with a high degree of disability and mortality. In recent years, there has been an increase in its incidence in relation to a reduction in vaccination adherence, accentuated by the COVID-19 pandemic. Read More

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Titerphilia - The Irresistible Urge to Measure Postimmunization Antibody Values.

Pediatr Infect Dis J 2022 06 6;41(6):490-491. Epub 2022 May 6.

Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Some physicians and parents request to measure antimeasles serum IgG antibodies after measles-mumps-rubella (MMR) vaccination. Often, vaccine skeptical parents want to know if their child is "immune" after the first dose to avoid the second dose. In the usual healthy child, this should be discouraged for the following reasons. Read More

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Determinants of B-Cell Compartment Hyperactivation in European Adolescents Living With Perinatally Acquired HIV-1 After Over 10 Years of Suppressive Therapy.

Front Immunol 2022 31;13:860418. Epub 2022 Mar 31.

Academic Department of Pediatrics (DPUO), Research Unit of Clinical Immunology and Vaccinology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Background: Despite a successful antiretroviral therapy (ART), adolescents living with perinatally acquired HIV (PHIV) experience signs of B-cell hyperactivation with expansion of 'namely' atypical B-cell phenotypes, including double negative (CD27-IgD-) and termed age associated (ABCs) B-cells (T-bet+CD11c+), which may result in reduced cell functionality, including loss of vaccine-induced immunological memory and higher risk of developing B-cells associated tumors. In this context, perinatally HIV infected children (PHIV) deserve particular attention, given their life-long exposure to chronic immune activation.

Methods: We studied 40 PHIV who started treatment by the 2 year of life and maintained virological suppression for 13. Read More

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Measles Experience, Practice, and Knowledge by Pediatricians in the Context of Resurgent US Outbreaks.

J Pediatr 2022 Jul 12;246:213-219.e1. Epub 2022 Apr 12.

Adult and Child Consortium for Health Outcomes Research and Delivery Science, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.

Objective: To assess measles experience, practice, and knowledge by pediatricians in the context of resurgent US outbreaks in 2018-2019.

Study Design: A nationally representative network of pediatricians were surveyed by email and mail from January to April 2020.

Results: The response rate was 67% (297 of 444). Read More

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Timeliness of routine childhood vaccinations in Indonesian infants in the first year of life.

Vaccine 2022 May 11;40(21):2925-2932. Epub 2022 Apr 11.

Department of Paediatrics, Faculty Medicine, Dentistry and Health Sciences, the University of Melbourne, Melbourne, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.

Background: Vaccines have proven to be one of the most effective strategies to control infectious diseases and contributed to childhood survival. While high vaccine coverages provide individual's and herd immunity, age-appropriate vaccination or vaccine timeliness is important for maximum vaccine's protection, but often not evaluated. We aimed to describe the timeliness of childhood vaccination for Indonesian infants and identify risk factors associated with delayed vaccination. Read More

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Exploring the impact of media and information on self-reported intentions to vaccinate against COVID-19: A qualitative interview-based study.

Hum Vaccin Immunother 2022 Nov 13;18(5):2048623. Epub 2022 Apr 13.

Canadian Center for Vaccinology & Scientific Staff, IWK Health Center, Halifax, Nova Scotia, Canada.

Background: The World Health Organization declared vaccine hesitancy a top threat to global health following resurgence of vaccine-preventable diseases close to eradication in many countries (e.g. measles). Read More

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November 2022

An Informed Approach to Vaccine Hesitancy and Uptake in Children.

Dela J Public Health 2022 Mar 29;8(1):60-64. Epub 2022 Mar 29.

Attending Physician, Divisions of Orthogenetics & Palliative Medicine, Nemours Children's Health; Clinical Associate Professor, Pediatrics, Sidney Kimmel Medical College, Thomas Jefferson University.

The tremendous success of vaccination programs worldwide over the past two centuries has produced a paradoxical effect whereby a lack of exposure to the devastating consequences of vaccine-preventable diseases has created an environment in which fear of the side effects of vaccines can overshadow concerns about the impact of the diseases they are meant to prevent. As vaccine hesitancy grew over the past twenty years, states passed legislation, such as non-medical exemptions from vaccination, that have cultivated pockets of poor vaccine uptake allowing for the return of vaccine-preventable diseases such as measles and pertussis. The COVID-19 pandemic has further intensified mistrust of vaccines, impacting both the reasons for vaccine hesitancy and the attributes of vaccine hesitant parents. Read More

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Immunological Memory and Affinity Maturation After Vaccination in Patients With Propionic Acidemia.

Front Immunol 2022 25;13:774503. Epub 2022 Mar 25.

Department of Child and Adolescent Health, Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria.

Earlier studies have recommended routine childhood immunization in patients with propionic acidemia (PA); however, the literature presents insufficient data on the response to vaccines, notably specific IgG concentrations and avidity maturation, after measles, mumps, rubella (MMR), and diphtheria/tetanus (DiphtTe) vaccinations in this population. In patients with PA, cellular and humoral changes of the immune system (e.g. Read More

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Inadequate protection against measles and rubella among pregnant women in Greece during the last measles outbreak.

J Infect 2022 Jun 7;84(6):e95-e97. Epub 2022 Apr 7.

Second Department of Pediatrics, National and Kapodistrian University of Athens, School of Medicine, 'P. & A. Kyriakou' Children's Hospital, Athens, Greece.

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Physician vaccination practices in mild to moderate inborn errors of immunity and retrospective review of vaccine completeness in IEI: results from the Canadian Immunization Research Network.

Allergy Asthma Clin Immunol 2022 Apr 9;18(1):32. Epub 2022 Apr 9.

Departments of Pediatrics and Community Health and Epidemiology, Canadian Center for Vaccinology, IWK Health Centre, Dalhousie University, Halifax, Canada.

Background And Objectives: Safety and effectiveness concerns may preclude physicians from recommending vaccination in mild/moderate inborn errors of immunity (IEI). This study describes attitudes and practices regarding vaccination among physicians who care for patients with mild/moderate B cell or mild/moderate combined immunodeficiencies (CID) and vaccination completeness among patients diagnosed with IEIs.

Methods: Canadian physicians caring for children with IEI were surveyed about attitudes and practices regarding vaccination in mild/moderate IEI. Read More

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A Predictor of Oxidative Stress in the Children with Measles: Thiol-Disulfide Homeostasis.

Turk Arch Pediatr 2022 Mar;57(2):200-204

Department of Pediatrics, Faculty of Medicine, Harran University, Şanlıurfa, Turkey.

Objective: Measles is an infectious disease, in which oxidative stress increases. Thiols are an antioxidant substance which play a critical role in programmed cell death, detoxification, and regulation of cellular enzymatic activity, and the thiol-disulfide balance is associated with some diseases. The purpose of this study was to evaluate the thiol-disulfide balance in children with measles. Read More

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