573,573 results match your criteria Pediatrics Limp

In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains.

Nature 2021 Jun 21. Epub 2021 Jun 21.

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Rapidly-emerging variants jeopardize antibody-based countermeasures against SARS-CoV-2. While cell culture experiments have demonstrated loss of potency of several anti-spike neutralizing antibodies against SARS-CoV-2 variant strains, the in vivo significance of these results remains uncertain. Using a panel of monoclonal antibodies (mAbs) corresponding to many in advanced clinical development by Vir Biotechnology, AbbVie, AstraZeneca, Regeneron, and Lilly, we report the impact on protection in animals against authentic SARS-CoV-2 variants including viruses with B. Read More

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The KAG motif of HLA-DRB1 (β71, β74, β86) predicts seroconversion and development of type 1 diabetes.

EBioMedicine 2021 Jun 18;69:103431. Epub 2021 Jun 18.

Department of Clinical Sciences, Lund University CRC, Skåne University Hospital, Jan Waldenströms gata 35, Skåne University Hospital SUS, Malmö SE-205 02, Sweden. Electronic address:

Background: HLA-DR4, a common antigen of HLA-DRB1, has multiple subtypes that are strongly associated with risk of type 1 diabetes (T1D); however, some are risk neutral or resistant. The pathobiological mechanism of HLA-DR4 subtypes remains to be elucidated.

Methods: We used a population-based case-control study of T1D (962 patients and 636 controls) to decipher genetic associations of HLA-DR4 subtypes and specific residues with susceptibility to T1D. Read More

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Endotrophin: Nominated for best supporting actor in the fibro-inflammatory saga.

EBioMedicine 2021 Jun 18;69:103447. Epub 2021 Jun 18.

Touchstone Diabetes Center, Department of Internal Medicine, the University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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Cognitive and neurological outcome of patients in the Dutch pyridoxine-dependent epilepsy (PDE-ALDH7A1) cohort, a cross-sectional study.

Eur J Paediatr Neurol 2021 Jun 7;33:112-120. Epub 2021 Jun 7.

Department of Paediatric Neurology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:

Background: Pyridoxine monotherapy in PDE-ALDH7A1 often results in adequate seizure control, but neurodevelopmental outcome varies. Detailed long-term neurological outcome is unknown. Here we present the cognitive and neurological features of the Dutch PDE-ALDH7A1 cohort. Read More

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Enterovirus D68 in hospitalized children with respiratory symptoms in Guangdong from 2014 to 2018: Molecular epidemiology and clinical characteristics.

J Clin Virol 2021 Jun 4;141:104880. Epub 2021 Jun 4.

Innovation Platform for Public Health of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, China; Department of Medical Laboratory, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong 510515, China. Electronic address:

Background: Enterovirus D68 (EV-D68) is an emerging pathogen in humans. EV-D68 causes a wide range of respiratory symptoms in children and has the propensity to cause severe complications. EV-D68 outbreaks are rarely investigated in mainland China. Read More

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Implementation Science to Improve Quality of Neurological Care.

Pediatr Neurol 2021 May 15;121:67-74. Epub 2021 May 15.

Department of Psychiatry & Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Behavioral Health QUERI, Little Rock, Arkansas.

Neurological disorders are the leading cause of disability and the second leading cause of death globally. To challenge this enormous disease burden, scientists are pursuing innovative solutions to maintain and improve the quality of neurological care. Despite the availability of many effective evidence-based practices, many patients with neurological disorders cannot access these (or receive them inefficiently after a long delay) and may be exposed to unnecessary, expensive, and potentially harmful treatments. Read More

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Consensus Statement for the Management and Treatment of Sturge-Weber Syndrome: Neurology, Neuroimaging, and Ophthalmology Recommendations.

Pediatr Neurol 2021 May 6;121:59-66. Epub 2021 May 6.

Department of Dermatology, University of California, Irvine School of Medicine, Irvine, California. Electronic address:

Background: Sturge-Weber syndrome (SWS) is a sporadic, neurocutaneous syndrome involving the skin, brain, and eyes. Because of the variability of the clinical manifestations and the lack of prospective studies, consensus recommendations for management and treatment of SWS have not been published.

Objective: This article consolidates the current literature with expert opinion to make recommendations to guide the neuroimaging evaluation and the management of the neurological and ophthalmologic features of SWS. Read More

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Magnetic Resonance Imaging Findings in Preterm Infants With Bilirubin Encephalopathy Beyond Three Years Corrected Age.

Pediatr Neurol 2021 May 28;121:56-58. Epub 2021 May 28.

Department of Pediatrics and Child Health, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.

Background: Magnetic resonance imaging (MRI) abnormalities in preterm infants with bilirubin encephalopathy (BE) become less clear as the infants age. We assessed MRI findings in children with preterm BE older than 36 months corrected age (CA).

Methods: In a previous questionnaire survey, hospitals were asked to provide head MRI data of patients older than 36 months CA. Read More

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Clinical and radiological outcomes of corrective exercises and neuromuscular electrical stimulation in children with flexible flatfeet: A randomized controlled trial.

Gait Posture 2021 Jun 12;88:297-303. Epub 2021 Jun 12.

Department of Physical Therapy For Pediatrics, Faculty of Physical Therapy, Cairo University, Egypt.

Background: Flexible flatfeet are common among children being scarcely symptomatic requires no specific treatment and resolves spontaneously. However, flexible flatfoot tends to advance and deteriorate overtime and eventually resulting in significant impairments such as plantar fasciitis and patellofemoral pain syndrome.

Research Question: What is the effect of corrective exercises and neuromuscular electrical stimulation in children with flexible flatfeet?

Method: This is a randomized controlled trial with 72 children, seven to twelve yearsold, randomly assigned to either intervention or control group (36 children for each group) and engaged in a four months (3 sessions/week) of corrective exercise and neuromuscular electrical stimulation or corrective exercise and sham neuromuscular electrical stimulation respectively. Read More

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Paranasal mucoceles in children with cystic fibrosis: Management of a not so rare clinical condition.

Am J Otolaryngol 2021 Jun 16;42(6):103107. Epub 2021 Jun 16.

Unit of Pediatric Otorhinolaryngology, Spedali Civili, Brescia, Italy. Electronic address:

Purpose: Paranasal mucocele (PM) is reported as a complication in children with cystic fibrosis (CF) in up to 4% of patients. The objective of this study was to identify PMs in the personal large series of children with CF and to assess their diagnosis and treatment.

Material And Methods: Medical records of children with CF and PM who were admitted and treated by means of endoscopic nasal surgery between 2004 and 2020 were retrospectively reviewed. Read More

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The European multistakeholder PanCareFollowUp project: novel, person-centred survivorship care to improve care quality, effectiveness, cost-effectiveness and accessibility for cancer survivors and caregivers.

Eur J Cancer 2021 Jun 18;153:74-85. Epub 2021 Jun 18.

Princess Máxima Centre for Paediatric Oncology, Heidelberglaan 25, Utrecht, 3584 CS, the Netherlands.

Background: The majority of childhood cancer survivors are at risk of treatment-related adverse health outcomes. Survivorship care to mitigate these late effects is endorsed, but it is not available for many adult survivors of childhood cancer in Europe. The PanCareFollowUp project was initiated to improve their health and quality of life (QoL) by facilitating person-centred survivorship care. Read More

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Concomitant use of combined hormonal contraceptives and antifibrinolytic agents for the management of heavy menstrual bleeding: A practice pattern survey.

Thromb Res 2021 Jun 11;204:95-100. Epub 2021 Jun 11.

Division of Hematology Oncology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.

Introduction: Concomitant antifibrinolytic agents and combined hormonal contraceptives (CHC) have been anecdotally used to manage refractory heavy menstrual bleeding (HMB). Yet, there remains uncertainty among clinicians regarding the safety of this therapeutic option as concomitant CHC is listed as a contraindication to tranexamic acid use in the United States.

Aim: To describe current treatment practices and physician-reported safety and effectiveness of concomitant antifibrinolytics and CHCs. Read More

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On the origin of germ cell neoplasia in situ: Dedifferentiation of human adult Sertoli cells in cross talk with seminoma cells in vitro.

Neoplasia 2021 Jun 18;23(7):731-742. Epub 2021 Jun 18.

Department of Internal Medicine, Member of the German Center for Lung Research (DZL), Germany; Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Member of the DZL, Member of CPI, Bad Nauheim, Germany; Institute for Lung Health (ILH), Justus-Liebig-University, Giessen, Germany. Electronic address:

Germ cell neoplasia in situ (GCNIS) is the noninvasive precursor of testicular germ cell tumors type II, the most common cancer in young men, which originates from embryonic germ cells blocked in their maturation. GCNIS is associated with impaired Sertoli cells (SCs) that express fetal keratin 18 (KRT18) and the pluripotency factor SRY-Box transcription factor 2 (SOX2). According to the current theory concerning the origin of GCNIS, these SCs are prepubertal cells arrested in their maturation due to (epi)genetic anomalies and/or environmental antiandrogens. Read More

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Analysis of cold activation of the contact system in hereditary angioedema with normal C1 inhibitor.

Mol Immunol 2021 Jun 18;136:150-160. Epub 2021 Jun 18.

Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States.

Hereditary angioedema (HAE) attacks are caused by excessive activation of the contact system. Understanding how the contact system is activated in HAE, especially in patients with normal C1 inhibitor (HAEnCI), is essential to effectively treat this disease. Contact system activation involves the cleavage of several proteins including Factor XII (FXII), high molecular weight kininogen (HK), prekallikrein, sgp120 (ITIH4) and C1 inhibitor (C1-INH) before the subsequent generation of bradykinin that mediates HAE. Read More

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Clinical outcomes for young children diagnosed with asthma versus reactive airway disease.

Acad Pediatr 2021 Jun 18. Epub 2021 Jun 18.

University of Rochester School of Medicine and Dentistry, Rochester, NY. Electronic address:

Objective: Clinical diagnoses of asthma and reactive airway disease (RAD) in young children are subjective. We examined how often children were diagnosed with asthma vs RAD, and whether preventive care and 2-year clinical outcomes differed based on initial diagnosis.

Methods: We conducted a retrospective cohort analysis of children (2-7 years) from a university-based general pediatrics practice who had been diagnosed with RAD or asthma. Read More

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Parenting Pediatric Residents.

Susan Walker

Acad Pediatr 2021 Jun 18. Epub 2021 Jun 18.

Renaissance School of Medicine at Stony Brook University, Division of General Pediatrics, 600 Main Street, Suite A, Center Moriches, NY 11934, United States. Electronic address:

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Status of Antimicrobial Stewardship Programs in Korean hospitals including small to medium-sized hospitals with the awareness and demands by physicians: A nationwide survey in 2020.

J Glob Antimicrob Resist 2021 Jun 18. Epub 2021 Jun 18.

Division of Infectious Diseases, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Objectives: This study aimed at identifying the status of ASPs in Korean hospitals with medium- to small-sized hospitals, as well as the awareness and demands about ASPs by physicians.

Methods: The questionnaire was designed based on a questionnaire from a previous nationwide survey in 2018 targeting large hospitals in Korea, and modified to reflect the results of in-depth interviews with non-infectious diseases physicians at secondary care hospitals. The survey targeted all hospitals with ≥ 150 beds in South Korea and performed in May-June 2020. Read More

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The Risk of Allergic Reaction to SARS-CoV-2 Vaccines and Recommended Evaluation and Management: A Systematic Review, Meta-analysis, GRADE Assessment, and International Consensus Approach.

J Allergy Clin Immunol Pract 2021 Jun 18. Epub 2021 Jun 18.

Department of Paediatrics, Royal College of Surgeons, Dublin, Ireland.

Concerns for anaphylaxis may hamper SARS-CoV-2 immunization efforts. We convened a multi-disciplinary group of international experts in anaphylaxis comprised of allergy, infectious disease, emergency medicine, and front-line clinicians to systematically develop recommendations regarding SARS-CoV-2 vaccine immediate allergic reactions. Medline, EMBASE, Web of Science, the WHO global coronavirus database, and the grey literature (inception-March 19, 2021) were systematically searched. Read More

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Feasibility and Preliminary Validity of Mobile Spirometry in Pediatric Asthma.

J Allergy Clin Immunol Pract 2021 Jun 18. Epub 2021 Jun 18.

Department of Pediatrics, University of Cincinnati College of Medicine; Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center.

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Recognition of Hematopoietic Stem Cell Transplant and Cellular Therapy Expertise to Promote Care Accessibility: A Formally Credentialed Area of Focus Competence in Canada.

Transplant Cell Ther 2021 Jun 18. Epub 2021 Jun 18.

University of Calgary, Alberta, Canada; Division of Nephrology, University of Ottawa, Ontario, Canada; Section of Pediatric Oncology/BMT, Departments of Oncology or Pediatrics, Cumming School of Medicine.

Background: Hematopoietic stem cell transplantation (HSCT) and cellular therapy (CT) exploit the therapeutic potential of manipulated or unmanipulated hematopoietic cells to treat diseases. While initially dedicated to the treatment of hematological malignancies and disorders, its efficacy is currently being investigated in several diseases and cancers. Indications are currently booming. Read More

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Allogenic hematopoietic stem cell transplantation is feasible in pediatric patients with an active or recently diagnosed invasive fungal infection.

Transplant Cell Ther 2021 Jun 18. Epub 2021 Jun 18.

Hematopoietic stem cell transplantation unit, Princess Maxima Center for Pediatric Oncology/Wilhelmina Children's hospital, UMC Utrecht, University Utrecht, The Netherlands.

Background: Data on the outcome of allogenic hematopoietic stem cell transplantation (HSCT) in pediatric patients with a history of invasive fungal infection (IFI) is limited.

Objective: The aim of this study was to report on the feasibility and outcome of allogenic HSCT in pediatric patients with an active or recently diagnosed IFI.

Study Design: In this retrospective single center study 317 children underwent an allogenic HSCT (January 2012 - June 2020), of which 23 patients had an active or recent (Read More

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Reduction in late mortality among patients with Multiple Myeloma treated with Autologous Peripheral Blood Stem Cell Transplantation - a BMTSS Report.

Transplant Cell Ther 2021 Jun 18. Epub 2021 Jun 18.

Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL; Division of Hematology-Oncology, Department of Pediatrics, University of Alabama at Birmingham, AL. Electronic address:

Background: Therapeutic practices for multiple myeloma (MM) have evolved, such that novel-agent-based therapy and autologous peripheral blood stem cell transplantation (aPBSCT) is the current standard. Whether cause-specific mortality has changed with time remains unclear.

Objective: we examined late cause-specific mortality among patients with MM receiving aPBSCT from 1989-2014. Read More

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Sulforaphane improves mitochondrial metabolism in fibroblasts from patients with fragile X-associated tremor and ataxia syndrome.

Neurobiol Dis 2021 Jun 18:105427. Epub 2021 Jun 18.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, United States of America; Medical Investigations of Neurodevelopmental Disorders (M.I.N.D.) Institute, University of California Davis, CA 95817, USA. Electronic address:

CGG expansions between 55 and 200 in the 5'-untranslated region of the fragile-X mental retardation gene (FMR1) increase the risk of developing the late-onset debilitating neuromuscular disease Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS). While the science behind this mutation, as a paradigm for RNA-mediated nucleotide triplet repeat expansion diseases, has progressed rapidly, no treatment has proven effective at delaying the onset or decreasing morbidity, especially at later stages of the disease. Here, we demonstrated the beneficial effect of the phytochemical sulforaphane (SFN), exerted through NRF2-dependent and independent manner, on pathways relevant to brain function, bioenergetics, unfolded protein response, proteosome, antioxidant defenses, and iron metabolism in fibroblasts from FXTAS-affected subjects at all disease stages. Read More

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Acceptability of Small-Sized Oblong tablets in Comparison to Syrup and Mini-tablets in Infants and Toddlers: A Randomized Controlled Trial.

Eur J Pharm Biopharm 2021 Jun 18. Epub 2021 Jun 18.

Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Moorenstrasse 5, 40225 Düsseldorf, Germany. Electronic address:

Objective: There is limited evidence for the acceptability of various drug formulations holding the potential to improve medicines administration to children. Suitable formulations need to meet the requirements of pediatric patients. Previous studies have demonstrated the acceptance of mini-tablets. Read More

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Loss of regulatory capacity in T regulatory cells upon rhinovirus infection.

J Allergy Clin Immunol 2021 Jun 18. Epub 2021 Jun 18.

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. Electronic address:

Background: Respiratory infections with rhinoviruses (RV) are strongly associated with the development and exacerbations of asthma and pose an additional health risk for allergic subjects.

Objective: How RV infections and chronic allergic diseases are linked, and which role RV plays in the breaking of tolerance in T regulatory cells (Tregs) is unknown. Therefore this study aims to investigate the effects of RV on Tregs. Read More

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Chronic non-cancer pain in adolescents - a narrative review.

Braz J Anesthesiol 2021 Jun 18. Epub 2021 Jun 18.

Centro Hospitalar e Universitário de Coimbra, Serviço de Anestesiologia, Departamento de Pediatria, Coimbra, Portugal.

Introduction: Chronic pain is defined as a pain lasting more than 3-6 months. It is estimated that 25% of the pediatric population may experience some kind of pain in this context. Adolescence, corresponding to a particular period of development, seems to present the ideal territory for the appearance of maladaptive mechanisms that can trigger episodes of persistent or recurrent pain. Read More

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Production of functional human fetal hemoglobin in Nicotiana benthamiana for development of hemoglobin-based oxygen carriers.

Int J Biol Macromol 2021 Jun 18. Epub 2021 Jun 18.

Department of Plant Breeding, Swedish University of Agricultural Sciences, Alnarp, Sweden. Electronic address:

Hemoglobin based oxygen carriers (HBOCs) have long been pursued to meet clinical needs by using native hemoglobin (Hb) from human or animal blood, or recombinantly produced Hb, but the development has been impeded by safety and toxicity issues. Herewith we report the successful production of human fetal hemoglobin (HbF) in Nicotiana benthamiana through Agrobacterium tumefaciens mediated transient expression. HbF is a heterotetrameric protein composed of two identical α- and two identical γ-subunits, held together by hydrophobic interactions, hydrogen bonds, and salt bridges. Read More

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NPHP1 gene-associated nephronophthisis is associated with an occult retinopathy.

Kidney Int 2021 Jun 18. Epub 2021 Jun 18.

Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Electronic address:

Biallelic deletions in the NPHP1 gene are the most frequent molecular defect of nephronophthisis, a kidney ciliopathy and leading cause of hereditary end-stage kidney disease. Nephrocystin 1, the gene product of NPHP1, is also expressed in photoreceptors where it plays an important role in intra-flagellar transport between the inner and outer segments. However, the human retinal phenotype has never been investigated in detail. Read More

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Distinct antiretroviral mechanisms elicited by a viral mutagen.

J Mol Biol 2021 Jun 18:167111. Epub 2021 Jun 18.

Institute for Molecular Virology, University of Minnesota - Twin Cities, Minneapolis, Minnesota 55455, USA; Division of Basic Sciences, School of Dentistry, University of Minnesota - Twin Cities, Minneapolis, Minnesota 55455, USA; Comparative Molecular Biosciences Graduate Program, University of Minnesota - Twin Cities, Minneapolis, Minnesota 55455, USA; Veterinary Medicine Graduate Program, University of Minnesota - Twin Cities, Minneapolis, Minnesota 55455, USA; Masonic Cancer Center, University of Minnesota - Twin Cities, Minneapolis, Minnesota 55455, USA; Center for Drug Design, University of Minnesota - Twin Cities, Minneapolis, Minnesota 55455, USA. Electronic address:

5-aza-cytidine (5-aza-C) has been shown to be a potent human immunodeficiency virus type 1 (HIV-1) mutagen that induces G-to-C hypermutagenesis by incorporation of the reduced form (i.e., 5-aza-dC, 5-aza-dCTP). Read More

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Carboxylesterase 1d (Ces1d) does not contribute to cholesteryl ester hydrolysis in the liver.

J Lipid Res 2021 Jun 18:100093. Epub 2021 Jun 18.

Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada; Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Mouse carboxylesterase 1d (Ces1d) and its human ortholog CES1 have been described to possess lipase activity and play a role in hepatic triacylglycerol (TG) metabolism and very-low density lipoprotein (VLDL) assembly. Liver is a central organ regulating cholesterol synthesis, storage, transport, and elimination. It has been proposed that Ces1d/CES1 might also catalyze cholesteryl ester (CE) hydrolysis in the liver and be responsible for the hydrolysis of high-density lipoprotein (HDL)-derived CE, thus contributing to the final step in the reverse cholesterol transport (RCT) pathway, where cholesterol is secreted from the liver into bile and feces, either directly or after conversion to water-soluble bile salts. Read More

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