88 results match your criteria Pediatrics Limp


Breath-Holding Spells in Pediatrics: A Narrative Review of the Current Evidence.

Curr Pediatr Rev 2018 Nov 12. Epub 2018 Nov 12.

Department of Paediatrics, The Chinese University of Hong Kong, Shatin. Hong Kong.

Background: Breath-holding spells are common, frightening, but fortunately benign events. Familiarity with this condition is important so that an accurate diagnosis can be made.

Objective: To familiarize physicians with the clinical manifestations, diagnosis, evaluation, and management of children with breath-holding spells. Read More

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http://dx.doi.org/10.2174/1573396314666181113094047DOI Listing
November 2018
1 Read

A novel homozygous W99G mutation in CLDN-16 gene causing familial hypomagnesemic hypercalciuric nephrocalcinosis in Turkish siblings.

Turk J Pediatr 2018 ;60(1):76-80

Departments of Pediatric Nephrology, İzmir Tepecik Training and Research Hospital, , Izmir.

Alparslan C, Öncel EP, Akbay S, Alaygut D, Mutlubaş F, Tatlı M, Konrad M, Yavaşcan Ö, Kasap-Demir B. A novel homozygous W99G mutation in CLDN-16 gene causing familial hypomagnesemic hypercalciuric nephrocalcinosis in Turkish siblings. Turk J Pediatr 2018; 60: 76-80. Read More

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http://dx.doi.org/10.24953/turkjped.2018.01.011DOI Listing
January 2018
24 Reads

Irritable Hip as the Inaugural Symptom for Neuroblastoma.

Case Rep Orthop 2018 28;2018:7428350. Epub 2018 Jun 28.

Pediatrics Department, Centro Hospitalar Tâmega e Sousa, Guilhufe, Portugal.

Case Report: A four-year-old girl presented with fever and a painful limp in the left hip. Pain characteristics and anemia detected in the blood analyses were the first warning signs that the hip process was not standard. Although the primary suspicion was of septic arthritis, a CT scan of the abdomen revealed an adrenal neuroblastoma. Read More

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http://dx.doi.org/10.1155/2018/7428350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046166PMC
June 2018
1 Read

Scurvy: A rare cause for limp in a child with autism spectrum disorder.

J Paediatr Child Health 2018 Dec 27;54(12):1375-1377. Epub 2018 Jun 27.

Department of Radiology, Sunshine Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/jpc.14098DOI Listing
December 2018
3 Reads

Two-Year-Old With a Limp and Suspected Nonaccidental Injury.

J Pediatr Gastroenterol Nutr 2018 Jul;67(1):e11

Center for Nutrition at Boston Children's Hospital, Harvard Medical School, MA.

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http://dx.doi.org/10.1097/MPG.0000000000001161DOI Listing
July 2018
1 Read

Closed Reduction, Osteotomy, and Fibular Graft Are Effective in Treating Pediatric Femoral Neck Pseudarthrosis After Infection.

Clin Orthop Relat Res 2018 Jul;476(7):1479-1490

R. K. Kanojia, S. Gupta, Department of Orthopaedics, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India A. Kumar, Department of Paediatrics and Neonatology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India B. K. Reddy, Department of Orthopaedics, Ashwini Hospital CDA Sector 1, Cuttack, Orissa, India.

Background: When treatment of acute septic arthritis of the hip is delayed, severe sequelae can occur. This may take the form of coxa breva, vara, or valga. Pseudoarthrosis of the femoral neck is a rare complication with only a few studies to guide treatment. Read More

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http://dx.doi.org/10.1097/01.blo.0000533616.93007.46DOI Listing
July 2018
14 Reads
2.770 Impact Factor

A 13-year-old girl with fever and limp.

Paediatr Child Health 2017 Mar 30;22(1):35-36. Epub 2017 Mar 30.

Section of Hospital Pediatrics, Alberta Children's Hospital, University of CalgaryCalgary, Alberta.

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http://dx.doi.org/10.1093/pch/pxw005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804967PMC
March 2017
3 Reads

Acute Septic Arthritis of the Knee Caused by in a 5-Year-Old Cameroonian Boy.

Front Pediatr 2017 6;5:230. Epub 2017 Nov 6.

Research Unit on Infectious and Emerging Tropical Diseases (URMITE), UM63, CNRS 7278, IRD 198, INSERM 1095, Aix-Marseille Université, IHU Méditerranée Infection, Marseille, France.

is an important cause of invasive infections in young children from Western countries. Although increasing reports indicate that this organism is the leading agent of bone and joint infections in early childhood, data on infections from resource-limited settings are scarce, and none has yet been reported in Africa. We herein report the diagnostic and epidemiological investigations of the first case of arthritis identified in a child from sub-Saharan Africa. Read More

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http://dx.doi.org/10.3389/fped.2017.00230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681518PMC
November 2017
11 Reads

Non-traumatic limping in Paediatric Emergencies: Epidemiology, evaluation and results.

Rev Esp Cir Ortop Traumatol 2018 Mar - Apr;62(2):127-133. Epub 2017 Nov 12.

Servicio de Pediatría, Sección Urgencias Pediátricas, Hospital Clínico Universitario de Valencia, Valencia, España.

Introduction: Non-traumatic limping is a common reason for consultation in paediatric emergencies. Although transient synovitis of the hip (TS) is the most frequent diagnosis, there are cases of limping secondary to serious pathologies. The aim of this review is to describe the variables related to non-traumatic limp that come to the paediatric emergency department to establish the best management protocol, making the most of resources and speeding up emergency care. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18884415173015
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http://dx.doi.org/10.1016/j.recot.2017.10.004DOI Listing
October 2018
4 Reads

Point-of-Care Ultrasound Identification of a Psoas Abscess in a Child Presenting With Hip Pain.

Authors:
Julia K Deanehan

Pediatr Emerg Care 2017 Jun;33(6):437-439

From the Division of Pediatric Emergency Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Johns Hopkins Children's Center, Baltimore, MD.

This case-report describes a 4-year-old girl brought to the emergency department for the evaluation of limp and elevated inflammatory markers. The patient's history and physical examination did not reveal a clear source of pathology. Point-of-care ultrasound identified a right-sided psoas abscess that was confirmed with computed tomography scan. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001159DOI Listing
June 2017
8 Reads

Early diagnosis of scurvy based on radiology and dietary history.

Pediatr Int 2017 Mar;59(3):357-358

Department of Radiology, Tokyo Metropolitan Children's Medical Center, Fuchu, Tokyo, Japan.

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http://dx.doi.org/10.1111/ped.13183DOI Listing
March 2017
5 Reads

Obstructed Infradiaphragmatic Total Anomalous Pulmonary Venous Return in a 13-Day-Old Infant Presenting Acutely to the Emergency Department: A Case Report.

J Emerg Med 2017 Jun 10;52(6):e239-e243. Epub 2017 Mar 10.

Department of Emergency Medicine, University of Arizona College of Medicine, Tucson, Arizona; Department of Pediatrics, University of Arizona College of Medicine, Tucson, Arizona.

Background: Total anomalous pulmonary venous return (TAPVR) is an uncommon congenital heart defect. Obstructed forms are more severe, and typically present earlier in life, usually in the immediate newborn period, with symptoms of severe cyanosis and respiratory failure.

Case Report: A 13-day-old boy presented to the emergency department (ED) with respiratory extremis. Read More

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http://dx.doi.org/10.1016/j.jemermed.2017.01.051DOI Listing
June 2017
9 Reads

Growing Pains.

Sports Health 2017 Mar/Apr;9(2):132-138. Epub 2017 Feb 8.

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.

Context: The term growing pains describes a common, benign syndrome of recurrent discomfort that occurs in young children. First described in the 1800s, the etiology of this condition remains unclear. The peak incidence does not correspond to a time of rapid growth. Read More

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http://dx.doi.org/10.1177/1941738117692533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349398PMC
July 2017
2 Reads

Significant Sleep Dysregulation in a Toddler With Developmental Delay.

J Dev Behav Pediatr 2017 Feb/Mar;38 Suppl 1:S23-S25

*Division of Child Development and Community Health, University of California San Diego, Rady Children's Hospital, San Diego, CA; †Alpert Medical School at Brown University, Providence, RI; ‡East Bay Pediatrics (Berkeley, California), Clinical Professor of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA.

Case: Derrick's parents made an appointment with a new pediatrician for a second opinion about disordered sleep. Now 22-months old, he was evaluated at 18 months of age for developmental delay when he was found to have "a regulatory disorder associated with delays in language and motor development, hypotonia and significant sleep problems." The parents are now most concerned about his sleeping pattern. Read More

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http://dx.doi.org/10.1097/DBP.0000000000000391DOI Listing
December 2017
8 Reads

Primary psoas abscess caused by group A streptococcus in a child: Case report with microbiologic findings.

J Infect Chemother 2016 Dec 28;22(12):811-814. Epub 2016 Sep 28.

Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address:

Primary abscess of the iliopsoas muscle in children is uncommon, especially due to Streptococcus pyogenes (group A streptococcus: GAS), which causes a variety of diseases ranging from pharyngitis to invasive life-threatening infection. We present primary iliopsoas abscess in a nine-year-old boy presenting with fever, mild disturbance of consciousness, limp, and pain in the right loin. Magnetic resonance imaging and isolation of GAS from both blood and abscess samples led us to the confirmative diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1341321X163009
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http://dx.doi.org/10.1016/j.jiac.2016.06.011DOI Listing
December 2016
15 Reads

Pediatric pelvic pyomyositis: initial MRI can be misleading.

J Pediatr Orthop B 2016 Nov;25(6):520-524

aDepartment of Surgery, Division of Pediatric Surgery, Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, TennesseebDepartment of Orthopedic Surgery & Rehabilitation, William Beaumont Army Medical CentercDepartment of Pediatrics, El Paso Children's HospitaldDepartment of Orthopedic Surgery, Texas Tech University Health Science Center, El Paso, TexaseDepartment of Anesthesiology, University of Arizona College of Medicine, Tucson, Arizona, USA.

Pelvic pyomyositis is an infection of the skeletal muscles around the hip joint. Fever, hip pain, limp, and leukocytosis are common; however, the clinical picture is often vague. MRI is the current gold-standard imaging for pyomyositis. Read More

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http://dx.doi.org/10.1097/BPB.0000000000000295DOI Listing
November 2016
1 Read

Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice.

J Biol Chem 2016 Apr 23;291(16):8414-27. Epub 2016 Feb 23.

From the Division of Neonatology and

The Hermansky Pudlak syndromes (HPS) constitute a family of disorders characterized by oculocutaneous albinism and bleeding diathesis, often associated with lethal lung fibrosis. HPS results from mutations in genes of membrane trafficking complexes that facilitate delivery of cargo to lysosome-related organelles. Among the affected lysosome-related organelles are lamellar bodies (LB) within alveolar type 2 cells (AT2) in which surfactant components are assembled, modified, and stored. Read More

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http://dx.doi.org/10.1074/jbc.M116.720201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861416PMC
April 2016
10 Reads

2-Year-Old with a Limp and Suspected Non-Accidental Injury.

J Pediatr Gastroenterol Nutr 2016 Feb 9. Epub 2016 Feb 9.

*Medical Student, Emory University School of Medicine, Atlanta, GA†Medical School Graduate, Aga Khan University, Karachi, Pakistan‡Professor of Pediatrics, Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine, Atlanta, GA§Advanced Nutrition Fellow, Boston Children's Hospital, Harvard Medical School, Boston Massachusetts.

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http://dx.doi.org/10.1097/MPG.0000000000001161DOI Listing
February 2016
2 Reads

Advances in GBA-associated Parkinson's disease--Pathology, presentation and therapies.

Neurochem Int 2016 Feb 30;93:6-25. Epub 2015 Dec 30.

DST/NWU Preclinical Drug Development Platform, North-West University, Potchefstroom, 2520, South Africa.

GBA mutations are to date the most common genetic risk factor for Parkinson's disease. The GBA gene encodes the lysomal hydrolase glucocerebrosidase. Whilst bi-allelic GBA mutations cause Gaucher disease, both mono- and bi-allelic mutations confer risk for Parkinson's disease. Read More

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http://dx.doi.org/10.1016/j.neuint.2015.12.004DOI Listing
February 2016
5 Reads

Brief Report: Scurvy as a Manifestation of Food Selectivity in Children with Autism.

J Autism Dev Disord 2016 Apr;46(4):1464-70

Center for Nutrition, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.

Scurvy was diagnosed in seven children at Boston Children's Hospital. All of the children had a developmental disorder and autism was the most common. They had a long-standing history of food selectivity with diets devoid of fruits and vegetables, and none of the children were supplemented with a multivitamin. Read More

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http://dx.doi.org/10.1007/s10803-015-2660-xDOI Listing
April 2016
11 Reads

Infantile Apparent Life-Threatening Events, an Educational Review.

Emerg (Tehran) 2015 ;3(1):8-15

Emergency Medicine Department, Mazandaran University of Medical Sciences, Sari, Iran.

Many physicians have received a frantic call from anxious parents stating that their child had stopped breathing, become limp, or turned blue but then had recovered quickly. An apparent life-threatening event (ALTE) is defined as "an episode that is frightening to the observer, and is characterized by some combination of apnea, color change, marked change in muscle tone, choking, gagging, or coughing". The incidence of ALTE is reported to be 0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614610PMC
October 2015
2 Reads

A 6-Year-Old With Leg Cramps.

Pediatrics 2015 Oct 14;136(4):732-9. Epub 2015 Sep 14.

Departments of Pediatrics, and Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; and.

A 6-year-old girl presented with a history of leg pain and cramping that progressively worsened over a 2- to 3-week period of time. Her examination was notable for normal vital signs, limited range of motion of her left hip, and a limp. Inflammatory markers were slightly elevated, but the serum electrolytes, calcium, and magnesium, complete blood cell count and differential, and creatine kinase level were normal. Read More

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http://dx.doi.org/10.1542/peds.2015-0332DOI Listing
October 2015
6 Reads

An atypical limping teenager.

BMJ Case Rep 2015 Aug 14;2015. Epub 2015 Aug 14.

Paediatrics Emergency Department, Chelsea and Westminster NHS Foundation Trust, London, UK.

A 13-year-old boy presented with a 5-day history of left-sided limp of gradual onset. There was no history of trauma. He developed a fever and rigours a few days before presenting to the paediatric emergency department. Read More

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http://dx.doi.org/10.1136/bcr-2014-208469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550926PMC
August 2015
3 Reads

Bartonella Osteomyelitis of the Acetabulum: Case Report and Review of the Literature.

Vector Borne Zoonotic Dis 2015 Aug;15(8):463-7

2 Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio.

Introduction: Bartonella henselae commonly involves the mononuclear phagocyte system (MPS), and its most common presentation is lymphadenitis. Rarely, it can cause isolated osteomyelitis. We present a case of a 3 year old with constitutional symptoms and new onset of limp. Read More

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http://dx.doi.org/10.1089/vbz.2014.1758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628211PMC
August 2015
3 Reads

Tumor-induced rickets in a child with a central giant cell granuloma: a case report.

Pediatrics 2015 Jun;135(6):e1518-23

Departments of Pediatrics.

Tumor-induced osteomalacia/rickets is a rare paraneoplastic disorder associated with a tumor-producing fibroblast growth factor 23 (FGF23). We present a child with symptoms of rickets as the first clinical sign of a central giant cell granuloma (CGCG) with high serum levels of FGF23, a hormone associated with decreased phosphate resorption. A 3-year-old boy presented with a limp and 6 months later with painless growth of the jaw. Read More

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http://dx.doi.org/10.1542/peds.2014-2218DOI Listing
June 2015
12 Reads

Establishing the research priorities of paediatric emergency medicine clinicians in the UK and Ireland.

Emerg Med J 2015 Nov 12;32(11):864-8. Epub 2015 Feb 12.

Emergency Department, Bristol Royal Hospital for Children, Bristol, UK Academic Department of Emergency Care, University of the West of England, Bristol, UK.

Objective: Paediatric Emergency Research in the UK and Ireland (PERUKI) is a collaborative clinical studies group established in August 2012. It consists of a network of 43 centres from England, Ireland, Northern Ireland, Scotland and Wales, and aims to improve the emergency care of children through the performance of robust collaborative multicentre research within emergency departments. A study was conducted regarding the research priorities of PERUKI, to establish the research agenda for paediatric emergency medicine in the UK and Ireland. Read More

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http://emj.bmj.com/lookup/doi/10.1136/emermed-2014-204484
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http://dx.doi.org/10.1136/emermed-2014-204484DOI Listing
November 2015
6 Reads

The role of ultrasound in the emergency department evaluation of the acutely painful pediatric hip.

Pediatr Emerg Care 2015 Jan;31(1):54-8; quiz 59-61

Assistant Professor of Pediatrics and Director of Emergency Ultrasound (Plumb), Professor of Pediatrics (Bolte), *Division of Pediatric Emergency Medicine; Assistant Professor of Surgery and Director Emergency Ultrasound (Mallin), †Division of Emergency Medicine, University of Utah School of Medicine, Salt Lake City, UT.

Children presenting with hip pain or a limp are a diagnostic challenge for the clinician. The differential diagnosis is extensive, and the workup can be broad. This review focuses on differentiating between transient synovitis and septic arthritis of the hip. Read More

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/PEC.0000000000000332DOI Listing
January 2015
1 Read

Teriparatide as a systemic treatment for lower extremity nonunion fractures: a case series.

Endocr Pract 2015 Feb;21(2):136-42

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Objective: To investigate the effect of teriparatide (parathyroid hormone [1-34]) on the healing of long bone nonunion fractures.

Methods: We performed a retrospective chart review of patients with fracture nonunion, aged 10 to 99 years who were treated with teriparatide at the Children's Hospital of Philadelphia or the Hospital of the University of Pennsylvania between November 2002 and January 2013. The primary endpoints were radiographic evidence of callus formation and fracture union, ability to bear weight without affected limb limp, and normal range of motion and strength. Read More

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http://dx.doi.org/10.4158/EP14315.ORDOI Listing
February 2015
13 Reads

The LIMP-2/SCARB2 binding motif on acid β-glucosidase: basic and applied implications for Gaucher disease and associated neurodegenerative diseases.

J Biol Chem 2014 Oct 8;289(43):30063-74. Epub 2014 Sep 8.

From the Division of Human Genetics, Cincinnati Children's Hospital Medical Center, and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 and

The acid β-glucosidase (glucocerbrosidase (GCase)) binding sequence to LIMP-2 (lysosomal integral membrane protein 2), the receptor for intracellular GCase trafficking to the lysosome, has been identified. Heterologous expression of deletion constructs, the available GCase crystal structures, and binding and co-localization of identified peptides or mutant GCases were used to identify and characterize a highly conserved 11-amino acid sequence, DSPIIVDITKD, within human GCase. The binding to LIMP-2 is not dependent upon a single amino acid, but the interactions of GCase with LIMP-2 are heavily influenced by Asp(399) and the di-isoleucines, Ile(402) and Ile(403). Read More

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http://dx.doi.org/10.1074/jbc.M114.593616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208013PMC
October 2014
6 Reads

The muscle findings in a pediatric patient with live attenuated oral polio vaccine-related flaccid monoplegia.

Vaccine 2014 Sep 12;32(42):5379-81. Epub 2014 Aug 12.

Department of Pediatrics and Child Neurology, Oita University Faculty of Medicine, Oita 879-5593, Japan.

A pediatric patient, who was given live-attenuated oral polio vaccine twice without distinct gait disturbance during infancy, begun to present limp at 3 years. His gait disturbance became remarkable with aging. At 7 years, he was unable to dorsiflex the left ankle, and presented flaccid monoplegia of the left lower extremity, and the left Achilles tendon reflex was diminished. Read More

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http://dx.doi.org/10.1016/j.vaccine.2014.07.089DOI Listing
September 2014
10 Reads
3.624 Impact Factor

Imaging of nontraumatic acute hip pain in children: multimodality approach with attention to the reduction of medical radiation exposure.

Semin Ultrasound CT MR 2014 Aug 14;35(4):394-408. Epub 2014 May 14.

Tufts University School of Medicine, Baystate Medical Center, Springfield, MA.

Nontraumatic acute hip pain in children is common. However, the presentation and etiology is variable, including difficulty with weight bearing and abnormal gait. Barriers in communication, multiple possible etiologies, and age-specific anatomical variations of the pediatric hip make the evaluation of hip pain in children a difficult clinical diagnosis. Read More

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http://dx.doi.org/10.1053/j.sult.2014.05.001DOI Listing
August 2014
2 Reads

Slipped capital femoral epiphysis, fixation by single screw in situ: A kinematic and radiographic study.

Clin Biomech (Bristol, Avon) 2014 May 12;29(5):523-30. Epub 2014 Apr 12.

The Royal Children's Hospital, Australia; Murdoch Childrens Research Institute, Australia; The University of Melbourne, Department of Paediatrics, Australia.

Background: Slipped capital femoral epiphysis is known to produce characteristic deformities in the proximal femur, which affect hip motion and may cause a limp. This paper assessed the 3D gait kinematics in adolescents after single screw fixation of moderate to severe, stable, unilateral slipped capital femoral epiphysis. Our goals were to characterize the 3D kinematic patterns and to investigate the correlation between the severity of radiological deformity and severity of gait disturbance. Read More

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http://dx.doi.org/10.1016/j.clinbiomech.2014.03.012DOI Listing
May 2014
3 Reads
1.880 Impact Factor

The use of ultrasound to detect occult or unsuspected fractures in child abuse.

Pediatr Emerg Care 2014 Jan;30(1):43-6

From the *Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY; and †Division of Pediatric Emergency Medicine, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL.

Occult fractures due to child abuse can be difficult to identify because there is usually no history of trauma, and chief complaints are vague. In addition, the osseous injuries are often subtle, becoming obvious only after healing begins. Missed injuries can lead to inappropriate disposition of a patient and can cause children to be placed at high risk for further injury and death. Read More

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http://dx.doi.org/10.1097/PEC.0000000000000064DOI Listing
January 2014
3 Reads

Lysosomal integral membrane protein 2 (LIMP-2) restricts the invasion of Trypanosoma cruzi extracellular amastigotes through the activity of the lysosomal enzyme β-glucocerebrosidase.

Microbes Infect 2014 Mar 20;16(3):253-60. Epub 2013 Nov 20.

Department of Microbiology, Immunology and Parasitology, Escola Paulista de Medicina, UNIFESP, São Paulo, Brazil.

Lysosomal integral membrane protein 2 (LIMP-2, SCARB2) is directly linked to β-glucocerebrosidase enzyme (βGC) and mediates the transport of this enzyme from the Golgi complex to lysosomes. Active βGC cleaves the β-glycosidic linkages of glucosylceramide, an intermediate in the metabolism of sphingoglycolipids, generating ceramide. In this study we used mouse embryonic fibroblasts (MEFs) deficient for LIMP-2 and observed that these cells were more susceptible to infection by extracellular amastigotes of the protozoan parasite Trypanosoma cruzi when compared to wild-type (WT) fibroblasts. Read More

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http://dx.doi.org/10.1016/j.micinf.2013.11.004DOI Listing

Pulmonary hypertension associated with scurvy and vitamin deficiencies in an autistic child.

Pediatrics 2013 Dec 4;132(6):e1699-703. Epub 2013 Nov 4.

Boston Children's Hospital, Division of Critical Care Medicine, Department of Anesthesia, 300 Longwood Ave, Boston, MA 02115.

Restricted dietary intake is common among children with behavioral issues. Here we report a case of a severely autistic child who presented initially with limp but who soon developed cough, tachypnea, hypoxia, and tachycardia. An echocardiogram revealed evidence of pulmonary hypertension (PH) with severely dilated right ventricle and elevated right-sided pressures. Read More

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http://dx.doi.org/10.1542/peds.2012-3054DOI Listing
December 2013
6 Reads
5.473 Impact Factor

Avascular necrosis of femoral head as the initial manifestation of CML.

Pediatr Hematol Oncol 2014 Sep 2;31(6):568-73. Epub 2013 Oct 2.

Hematology-Oncology Unit, Department of Pediatrics, Advanced Pediatric Center, Postgraduate Institute of Medical Education and Research , Chandigarh , India.

A 12-year-old female is reported who presented with right hip pain for 6 months. With massive splenohepatomegaly and leukocytosis, CML was suspected and confirmed on bone-marrow examination and cytogenetics. Further investigations confirmed avascular necrosis (AVN) of the right femoral head. Read More

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http://dx.doi.org/10.3109/08880018.2013.831961DOI Listing
September 2014
8 Reads
2 Citations
0.963 Impact Factor

Pediatric hip: pearls and pitfalls.

Authors:
Kara G Gill

Semin Musculoskelet Radiol 2013 Jul 20;17(3):328-38. Epub 2013 Jun 20.

Division of Pediatric Radiology, Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792-3252, USA.

Pediatric hip pathology varies depending on patient age. Newborns are often screened for developmental dysplasia of the hip, whereas toddlers and older children can present later with pain, leg length discrepancy, or limp. Young children may have hip pain related to transient synovitis, septic arthritis, or Legg-Calvé-Perthes disease. Read More

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http://dx.doi.org/10.1055/s-0033-1348099DOI Listing
July 2013
3 Reads

Evaluation of interobserver agreement of apgar scoring in preterm infants.

Pediatrics 2012 Oct 24;130(4):e982-7. Epub 2012 Sep 24.

Department of Pediatrics, Division of Neonatology, Rainbow Babies and Children's Hospital, 11100 Euclid Ave, RBC Suite 3100, Cleveland, OH 44106, USA.

Background And Objectives: Apgar scoring is accepted by medical professionals both as a measure of the infant's clinical status and the infant's response to resuscitation. Recent studies, however, have suggested significant variability when used for scoring preterm infants. We hypothesized that agreement in Apgar scoring would improve with increasing gestational age and at low levels of respiratory support. Read More

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http://pediatrics.aappublications.org/content/pediatrics/130
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http://pediatrics.aappublications.org/cgi/doi/10.1542/peds.2
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http://dx.doi.org/10.1542/peds.2012-0368DOI Listing
October 2012
3 Reads

Traumatic hip dislocation in children.

Authors:
Nguyen Ngoc Hung

J Pediatr Orthop B 2012 Nov;21(6):542-51

Vietnam National Hospital of Pediatrics, Hanoi, Vietnam.

The aim of this study was to evaluate the outcomes of reduction in the treatment of traumatic posterior hip dislocation in children. Data of 22 pediatric patients (22 hips) with traumatic hip dislocation from January 1995 to December 2007 were analyzed. The clinical evaluation focused on symptoms, physical findings, and range of motion. Read More

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http://dx.doi.org/10.1097/BPB.0b013e328356371bDOI Listing
November 2012
2 Reads

An unusual cause of limp.

BMJ Case Rep 2012 Apr 4;2012. Epub 2012 Apr 4.

Department of Paediatrics, Maidstone Hospital, Maidstone, UK.

Limp is a common clinical presentation in children, seen both in acute and community practice. The incidence is thought to vary between countries with suggested figures between 1.5 and 3. Read More

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http://dx.doi.org/10.1136/bcr.11.2011.5229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339175PMC
April 2012
3 Reads

[Burkitt's lymphoma presenting as an intermittent limp].

Reumatol Clin 2011 Mar-Apr;7(2):139-40. Epub 2011 Feb 12.

Sección de Oncología Pediátrica, Hospital Universitario Doce de Octubre, Madrid, España.

Musculoskeletal pain is a frequent complaint in pediatrics usually related to benign conditions. However, it may also represent the initial symptom of serious diseases such as infections, malignancies or orthopedic emergencies. We present the case of a child diagnosed with Burkitt's lymphoma whose initial presentation was a limp. Read More

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http://dx.doi.org/10.1016/j.reuma.2010.07.006DOI Listing
February 2012
2 Reads

Factors associated with a longer time to access pediatric rheumatologists in Canadian children with juvenile idiopathic arthritis.

J Rheumatol 2010 Nov 17;37(11):2415-21. Epub 2010 Aug 17.

Department of Paediatrics, University of British Columbia and BC Children's Hospital, Vancouver, BC, Canada.

Objective: The Research on Arthritis in Canadian Children Emphasizing Outcomes (ReACCh Out) cohort is a prospective inception cohort of patients with newly diagnosed juvenile idiopathic arthritis (JIA) seen in 16 Canadian pediatric rheumatology (PR) centers. We used data from this cohort to explore factors associated with longer time from symptom onset to the first visit to (PR), and with longer time from first visit to a diagnosis of JIA.

Methods: We included children enrolled in ReACCh Out within 6 months of JIA diagnosis, for whom the dates of symptom onset and first PR visit were recorded. Read More

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http://www.jrheum.org/content/37/11/2415.full.pdf
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http://www.jrheum.org/cgi/doi/10.3899/jrheum.100083
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http://dx.doi.org/10.3899/jrheum.100083DOI Listing
November 2010
5 Reads

Short-term bisphosphonate therapy could ameliorate osteonecrosis: a complication in childhood hematologic malignancies.

Case Rep Med 2010 10;2010:206132. Epub 2010 Jun 10.

Pediatric Endocrinology and Adolescence, Department of Pediatrics, Hospital-University of Padova, 35128 Padova, Italy.

Osteonecrosis (ON) is a critical complication in the treatment of childhood leukemia and lymphoma. It particularly affects survivors of acute lymphoblastic leukemia and non-Hodgkin lymphoma reflecting the cumulative exposure to glucocorticosteroid therapy. ON is often multiarticular and bilateral, specially affecting weight-bearing joints. Read More

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http://www.hindawi.com/journals/crim/2010/206132/
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http://dx.doi.org/10.1155/2010/206132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892653PMC
July 2011
1 Read

[Musculoskeletal pain: a common initial sign of acute lymphoblastic leukaemia].

An Pediatr (Barc) 2010 Jun 22;72(6):428-31. Epub 2010 Apr 22.

Sección de Reumatología Infantil, Servicio de Pediatría, Hospital Doce de Octubre, Madrid, España.

Musculoskeletal pain is a common complaint in paediatrics usually due to benign diseases. Nevertheless neoplasms, particularly acute leukaemia, must be considered in the differential diagnosis. During the last 9 months 4 of the 9 patients diagnosed with acute leukaemia at our hospital presented with a limp, arthralgias, lumbar or bony pain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S16954033100012
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http://dx.doi.org/10.1016/j.anpedi.2010.01.014DOI Listing
June 2010
1 Read

Primary subacute Salmonella osteomyelitis of the navicular bone in a child with normal immunity.

J Pediatr Orthop B 2009 Sep;18(5):225-7

Department of Pediatrics, Ankara Diskapi Child Health Training and Research Hospital, Ministry of Health, Ankara, Turkey.

Primary subacute haematogenous osteomyelitis is one of the causes of limp. It usually involves tubular bones. Flat and small bones are affected less commonly. Read More

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http://dx.doi.org/10.1097/BPB.0b013e32832e9639DOI Listing
September 2009
1 Read

11-month-old child refuses to sit up.

Pediatr Ann 2008 May;37(5):290-3

Department of Pediatrics, University of Nebraska Medical Center, Nebraska, USA.

Discitis and vertebral osteomyelitis are rare in children and require a high index of suspicion for the timely diagnosis. The diagnosis should be considered in a child who develops a limp or in an infant who displays a postural or positional preference. Read More

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May 2008
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Are laboratory tests necessary in making the diagnosis of limb pains typical for growing pains in children?

Pediatr Int 2007 Dec;49(6):833-5

Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: The present study was conducted to determine if performing laboratory tests are necessary to exclude other possible diagnoses in a child with limb pains typical for growing pains according to history and physical examination.

Methods: A matched case-control study was carried out on children with limb pains who attended the Motahary clinic, Shiraz, Iran, in a 2 year period. The inclusion criteria were limb pains, which were recurrent and lasted for more than 3 months. Read More

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http://dx.doi.org/10.1111/j.1442-200X.2007.02447.xDOI Listing
December 2007
1 Read

Bone scan update.

Authors:
Helen R Nadel

Semin Nucl Med 2007 Sep;37(5):332-9

Division of Nuclear Medicine, Department of Radiology, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada.

The radionuclide bone scan is one of the most commonly performed pediatric nuclear medicine procedures. Bone scintigraphy is used as the diagnostic procedure of choice for diagnosis of bone and soft-tissue infection and can aid in the diagnosis of occult trauma without radiographic findings. There is a complimentary role for bone scintigraphy in the assessment of a child with suspected nonaccidental injury. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2007.06.001DOI Listing
September 2007
5 Reads

Chronic recurrent multifocal osteomyelitis is a differential of childhood limp.

Arch Dis Child 2006 Jan;91(1):30

Department of Paediatrics, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, UK.

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http://dx.doi.org/10.1136/adc.2004.071225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2083092PMC
January 2006