2,781 results match your criteria Pediatrics Kawasaki Disease


Decreased Steroid Hormone Receptor Expression in Kawasaki Disease Before IVIG Treatment.

Front Pediatr 2019 4;7. Epub 2019 Feb 4.

Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Kawasaki disease (KD) is anacute febrile coronary vasculitis disease in children. In general, this disease can be treated with a single dose of 2 g/kg intravenous immunoglobulin (IVIG). However, the best timing for administering steroid treatment in acute-stage KD is still under debate. Read More

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http://dx.doi.org/10.3389/fped.2019.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369254PMC
February 2019

Predictive risk factors of coronary artery aneurysms in Kawasaki disease.

Authors:
Hyang-Ok Woo

Korean J Pediatr 2019 Feb 19. Epub 2019 Feb 19.

Department of Pediatrics, Institute of Health Science, Gyeongsang National University College of Medicine, Jinju, Korea.

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http://dx.doi.org/10.3345/kjp.2019.00073DOI Listing
February 2019

Kawasaki disease: a comprehensive review.

Arch Med Sci Atheroscler Dis 2018 21;3:e41-e45. Epub 2018 Mar 21.

Department of Pediatrics, Robert Reid Cabral Children's Hospital affiliated to the University Iberoamericana UNIBE, School of Medicine, Santo Domingo, Dominican Republic.

Kawasaki disease is an acute systemic vasculitis that was first reported in 1961. Over the last 5 decades multiple papers have been published to further understand this disease. The diagnosis of Kawasaki disease is made based on the clinical findings. Read More

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http://dx.doi.org/10.5114/amsad.2018.74522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374576PMC

New biomarkers of Kawasaki disease identified by urine proteomic analysis.

FEBS Open Bio 2019 Feb 20;9(2):265-275. Epub 2018 Dec 20.

Department of Cardiology Beijing Children's Hospital Capital Medical University Beijing China.

Kawasaki disease (KD) is an acute systemic vasculitis that mainly afflicts infants and young children. The symptoms of KD are similar to those of various febrile diseases. Here, we attempted to develop accurate diagnostic biomarkers of KD by performing urine proteomic analysis of samples from healthy controls, patients with KD, and patients with another febrile disease, pneumonia (two patients). Read More

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http://dx.doi.org/10.1002/2211-5463.12563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356163PMC
February 2019
1 Read

Kawasaki Disease Presenting as Acute Colitis.

Indian J Pediatr 2019 Feb 13. Epub 2019 Feb 13.

Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, The CHILDS Trust Medical Research Foundation, 12-A, Nageswara Road, Nungambakkam, Chennai, Tamilnadu, 600034, India.

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http://dx.doi.org/10.1007/s12098-019-02866-yDOI Listing
February 2019
1 Read

Iron deficiency anemia as a predictor of coronary artery abnormalities in Kawasaki disease.

Korean J Pediatr 2019 Feb 8. Epub 2019 Feb 8.

Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Coronary artery abnormalities (CAA) are the most important complication of Kawasaki disease (KD). Iron deficiency anemia (IDA) is prevalent micronutrient deficiencies and its association with KD remains unknown. We hypothesized the presence of IDA could be a predictor of CAA. Read More

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http://dx.doi.org/10.3345/kjp.2018.06905DOI Listing
February 2019
1 Read

Platelet Activation Dynamics in Kawasaki Disease- Revisited.

Indian J Pediatr 2019 Mar 11;86(3):216-217. Epub 2019 Feb 11.

Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

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http://dx.doi.org/10.1007/s12098-019-02890-yDOI Listing
March 2019
1 Read

Antibiotic Unresponsive Cervical Lymphadenopathy and Node First Presentation of Kawasaki Disease.

Indian J Pediatr 2019 Feb 11. Epub 2019 Feb 11.

Department of Family Medicine, National University Health System, Singapore, Singapore.

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http://dx.doi.org/10.1007/s12098-019-02886-8DOI Listing
February 2019
1 Read

Biomarkers and clinical rating scales for sodium pyruvate therapy in patients with mitochondrial disease.

Mitochondrion 2019 Feb 7. Epub 2019 Feb 7.

Department of Clinical Laboratory, Tokyo Metropolitan Geriatric Hospital, Itabashi-ku, Japan.

Biomarkers and two clinical rating scales-the Japanese mitochondrial disease-rating scale (JMDRS) and Newcastle mitochondrial disease adult scale (NMDAS)-are clinically used when treating patients with mitochondrial disease. We explored the biomarker(s) and clinical rating scale(s) that are appropriate in preparing the protocol for a future clinical trial of sodium pyruvate (SP) therapy. A 48-week, prospective, single-centre, exploratory, clinical study enrolled 11 Japanese adult patients with genetically, biochemically, and clinically confirmed mitochondrial disease; they had intractable lactic acidosis and received SP (0. Read More

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http://dx.doi.org/10.1016/j.mito.2019.02.001DOI Listing
February 2019
1 Read

Myocardial fibrosis after adrenergic stimulation as a long-term sequela in a mouse model of Kawasaki disease vasculitis.

JCI Insight 2019 Feb 7;4(3). Epub 2019 Feb 7.

Departments of Biomedical Sciences and Pediatrics, Divisions of Infectious Diseases and Immunology.

Kawasaki disease (KD), the leading cause of acquired cardiac disease among children, is often associated with myocarditis that may lead to long-term myocardial dysfunction and fibrosis. Although those myocardial changes develop during the acute phase, they may persist for decades and closely correlate with long-term myocardial sequelae. Using the Lactobacillus casei cell wall extract-induced (LCWE-induced) KD vasculitis murine model, we investigated long-term cardiovascular sequelae, such as myocardial dysfunction, fibrosis, and coronary microvascular lesions following adrenergic stimuli after established KD vasculitis. Read More

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https://insight.jci.org/articles/view/126279
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http://dx.doi.org/10.1172/jci.insight.126279DOI Listing
February 2019
2 Reads

Hemodynamic variables in aneurysms are associated with thrombotic risk in children with Kawasaki disease.

Int J Cardiol 2019 Jan 28. Epub 2019 Jan 28.

Departments of Pediatrics, Bioengineering and Institute for Computational and Mathematical Engineering, Stanford University, USA. Electronic address:

Background: Thrombosis is a major adverse outcome associated with coronary artery aneurysms (CAAs) resulting from Kawasaki disease (KD). Clinical guidelines recommend initiation of anticoagulation therapy with maximum CAA diameter (D) ≥8 mm or Z-score ≥ 10. Here, we investigate the role of aneurysm hemodynamics as a superior method for thrombotic risk stratification in KD patients. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.01.092DOI Listing
January 2019
1 Read

Serum Exosomal microRNA Let-7i-3p as Candidate Diagnostic Biomarker for Kawasaki Disease Patients with Coronary Artery Aneurysm.

IUBMB Life 2019 Feb 6. Epub 2019 Feb 6.

Department of Clinical Biological Resource Bank, Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China.

Kawasaki disease (KD) is a systemic vasculitis syndrome that leads to coronary artery aneurysm (CAA). While echocardiography is the most important imaging modality for coronary artery assessment, a specific diagnostic biomarker complementary for CAA has not been reported. We aimed to analyze the profiles of exosomal miRNAs extracted from the serum of KD patients and controls to identify candidate biomarkers for CAA. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/iub.2015
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http://dx.doi.org/10.1002/iub.2015DOI Listing
February 2019
8 Reads
3.143 Impact Factor

An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease.

Dis Markers 2019 3;2019:2849695. Epub 2019 Jan 3.

Clinical Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Background: Kawasaki disease (KD) is an acute vasculitis disease that commonly causes acquired heart disease in children. Coronary artery aneurysm (CAA) is a major complication of KD. However, the pathogenesis of KD remains unclear. Read More

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http://dx.doi.org/10.1155/2019/2849695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335657PMC
January 2019
1 Read
2.174 Impact Factor

Lymph-node-first Kawasaki disease and giant coronary artery aneurysm.

Authors:
Bazlin Ramly

BMJ Case Rep 2019 Feb 1;12(2). Epub 2019 Feb 1.

Paediatric Department, University Hospital Waterford, Waterford, Ireland.

A 8-year-old Irish ethnicity girl presented with 3 days of fever with right-sided neck swelling which was first thought as acute tonsillitis with right-sided lymphadenitis. She was started on intravenous antibiotics. At day 7 of illness, she was diagnosed to have Kawasaki disease with clinical and biochemical evidence. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22689
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http://dx.doi.org/10.1136/bcr-2018-226897DOI Listing
February 2019
5 Reads

Infliximab, Is It Really a New Horizon for the Treatment of Kawasaki Disease?

Korean Circ J 2019 Feb;49(2):192-193

Division of Pediatric Cardiology, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.4070/kcj.2018.0460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351277PMC
February 2019
1 Read

Discontinuation of L-asparaginase and poor response to prednisolone are associated with poor outcome of ETV6-RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia.

Int J Hematol 2019 Jan 28. Epub 2019 Jan 28.

Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.

ETV6-RUNX1-positive B precursor acute lymphoblastic leukemia (B-ALL) is a common subtype of pediatric B-ALL that has shown excellent outcomes in contemporary clinical trials for pediatric B-ALL. Examinations of the possibility of reducing therapeutic intensity may thus be explored. This prospective study examined outcomes in 205 pediatric patients with ETV6-RUNX1-positive B-ALL uniformly treated following the Japan Association of Childhood Leukemia Study Group (JACLS) ALL-02 protocol. Read More

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http://dx.doi.org/10.1007/s12185-019-02599-wDOI Listing
January 2019
1 Read

Kawasaki disease shock syndrome complicated with macrophage activation syndrome in a 5-month old boy: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14203

Department of Pediatric Cardiology, Children's Hospital, Capital Institute of Pediatrics, Beijing, China.

Rationale: Kawasaki disease (KD) is an acute febrile systemic vasculitis of unknown etiology and often occurs in children under 5 years old. During the acute phase, approximately 5% of children with KD develop hypotension and shock, a severe condition termed KD shock syndrome (KDSS). Macrophage activation syndrome (MAS), another life-threatening complication, has been reported to be associated with KD, although rarely. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901250-0004
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http://dx.doi.org/10.1097/MD.0000000000014203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358384PMC
January 2019
4 Reads

Genome-wide transcriptome analysis to further understand neutrophil activation and lncRNA transcript profiles in Kawasaki disease.

Sci Rep 2019 Jan 23;9(1):328. Epub 2019 Jan 23.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Kawasaki disease (KD) is the most common cause of acquired cardiac disease in children in developed countries. However, little is known regarding the role of transcriptomic targets of KD in the disease progression and development of complications, especially coronary artery aneurysms (CAA). The aim of our study was to identify transcripts affected by KD and their potential role in the disease. Read More

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http://dx.doi.org/10.1038/s41598-018-36520-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344526PMC
January 2019
1 Read

Bacteriuria With CTX-M-8 Extended-Spectrum β-Lactamase-Producing in a Patient With Incomplete Kawasaki Disease.

Glob Pediatr Health 2019 9;6:2333794X18821944. Epub 2019 Jan 9.

Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.

We report the case of a 2-month-old infant with incomplete Kawasaki disease that presented as an apparent urinary tract infection. The patient's fever persisted despite antibiotic treatment. Intravenous immunoglobulin and aspirin therapy cured both the incomplete Kawasaki disease and bacterial pyuria. Read More

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http://dx.doi.org/10.1177/2333794X18821944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328953PMC
January 2019
1 Read

Diagnosis and Management of Kawasaki Disease.

JAMA Pediatr 2019 Jan 22. Epub 2019 Jan 22.

Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio.

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http://dx.doi.org/10.1001/jamapediatrics.2018.3307DOI Listing
January 2019
2 Reads

Defective Epstein-Barr virus in chronic active infection and haematological malignancy.

Nat Microbiol 2019 Mar 21;4(3):404-413. Epub 2019 Jan 21.

Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Epstein-Barr virus (EBV) infection is highly prevalent in humans and is implicated in various diseases, including cancer. Chronic active EBV infection (CAEBV) is an intractable disease classified as a lymphoproliferative disorder in the 2016 World Health Organization lymphoma classification. CAEBV is characterized by EBV-infected T/natural killer (NK) cells and recurrent/persistent infectious mononucleosis-like symptoms. Read More

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http://dx.doi.org/10.1038/s41564-018-0334-0DOI Listing
March 2019
18 Reads

Ultrasonic assessment of vascular function in Kawasaki disease.

Authors:
Hiroshi Katayama

J Med Ultrason (2001) 2019 Jan;46(1):1-2

Department of Pediatrics, Osaka Medical College, Osaka, Japan.

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http://dx.doi.org/10.1007/s10396-018-0922-xDOI Listing
January 2019
1 Read

Fertility preservation in adolescent and young adult cancer patients: From a part of a national survey on oncofertility in Japan.

Reprod Med Biol 2019 Jan 20;18(1):97-104. Epub 2018 Nov 20.

Department of Obstetrics and Gynecology St. Marianna University School of Medicine Kawasaki Japan.

Purpose: This study evaluated the current status of reproductive disorders and provision of information on oncofertility to female adolescent and young adult (AYA) cancer patients in Japan.

Methods: A national survey of AYA cancer survivors was conducted. Children were <15 years old, and AYAs were 15-39 years old. Read More

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http://dx.doi.org/10.1002/rmb2.12256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332751PMC
January 2019
2 Reads

Phosphorylated proteomics analysis of human coronary artery endothelial cells stimulated by Kawasaki disease patients serum.

BMC Cardiovasc Disord 2019 Jan 17;19(1):21. Epub 2019 Jan 17.

Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, No.601, West Huangpu Avenue, Guangzhou, 510632, Guangdong, China.

Background: Kawasaki disease (KD) is an acute febrile childhood systemic vasculitis that disturbs coronary arteries. The pathogenesis remains unknown. The study of phosphorylated proteins helps to elucidate the relevant pathophysiological mechanisms of cardiovascular disease. Read More

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https://bmccardiovascdisord.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s12872-018-0982-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337789PMC
January 2019
7 Reads

LAMP-based assay can rectify the diagnosis of Yersinia pseudotuberculosis infections otherwise missed by serology.

J Med Microbiol 2019 Feb 16;68(2):143-147. Epub 2019 Jan 16.

1​Department of Pediatrics, Kawasaki Medical School, Japan.

Background: Despite being a well-known but seldom encountered zoonotic pathogen, diagnosis of Yersinia pseudotuberculosis is not necessarily easy. Infected patients occasionally present with various symptoms resembling Kawasaki disease; thus discriminating the two in the acute phase is challenging. In addition to bacterial culture and serology, novel detection methods based on loop-mediated isothermal amplification (LAMP) are reported in the literature. Read More

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http://dx.doi.org/10.1099/jmm.0.000868DOI Listing
February 2019
1 Read

A case report of refractory kawasaki disease.

Authors:
S H Ng S Roshan

Med J Malaysia 2018 Dec;73(6):410-412

Hospital Sultanah Bahiyah, Department of Paediatrics, Kedah, Malaysia.

Kawasaki disease is an autoimmune disease that commonly affects children below the age of 5 years. It is a vasculitic disease of unknown aetiology effecting the skin, eyes, lymph nodes and mucosal layer. Intravenous Immunoglobulin (IVIG) and aspirin therapy are the mainstay treatment however a number of cases have been shown to be refractory to this treatment. Read More

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December 2018
1 Read

Demonstration of background rates of three conditions of interest for vaccine safety surveillance.

PLoS One 2019 15;14(1):e0210833. Epub 2019 Jan 15.

Public Health Ontario, Toronto, Ontario, Canada.

Introduction: Adverse events following immunization (AEFIs) are unwanted or unexpected health outcomes following vaccination, which may or may not be causally-linked to vaccines. AEFI reporting is important to post-marketing vaccine safety surveillance and has the potential to identify new or rare AEFIs, show increases in known AEFIs, and help to maintain public confidence in vaccine programs. Knowledge of the expected incidence (i. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210833PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333343PMC
January 2019
1 Read

Calcified Saccular Coronary Artery Aneurysm of Kawasaki Disease.

J Clin Rheumatol 2018 Nov 29. Epub 2018 Nov 29.

Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1097/RHU.0000000000000953DOI Listing
November 2018
2 Reads

Multiple Systemic Aneurysms in a Case of Neglected Kawasaki Disease.

J Paediatr Child Health 2019 Jan;55(1):117

Department of Paediatrics KSD Hospital, Kolkata, India.

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http://dx.doi.org/10.1111/jpc.14303DOI Listing
January 2019
1 Read

Coronary artery dilation associated with anti-synthetase syndrome in an adolescent.

Pediatr Rheumatol Online J 2019 Jan 10;17(1). Epub 2019 Jan 10.

Department of Pediatrics, University of Texas McGovern Medical School, 6431 Fannin St. MSB 3.228, Houston, TX, USA.

Background: Idiopathic inflammatory myopathies (IIM) are a group of systemic autoimmune disorders primarily affecting skeletal muscle. Pediatric coronary artery dilation is frequently discussed in Kawasaki disease. However, it has yet to be reported in the IIMs or antisynthetase syndrome. Read More

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https://ped-rheum.biomedcentral.com/articles/10.1186/s12969-
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http://dx.doi.org/10.1186/s12969-019-0304-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329119PMC
January 2019
4 Reads

The Epidemiology and Pathogenesis of Kawasaki Disease.

Front Pediatr 2018 11;6:374. Epub 2018 Dec 11.

Department of Pediatrics, Northwestern University Feinberg School of Medicine, The Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States.

Epidemiologic and clinical features of Kawasaki Disease (KD) strongly support an infectious etiology. KD is worldwide, most prominently in Japan, Korea, and Taiwan, reflecting increased genetic susceptibility among Asian populations. In Hawaii, KD rates are 20-fold higher in Japanese ethnics than in Caucasians, intermediate in other ethnicities. Read More

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http://dx.doi.org/10.3389/fped.2018.00374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298241PMC
December 2018
1 Read

How Should We Classify Kawasaki Disease?

Front Immunol 2018 14;9:2974. Epub 2018 Dec 14.

Rheumatology Unit, Department of Neurosciences, Psychology, Drug Research and Child Health, Meyer Children's Hospital, University of Florence, Florence, Italy.

The exact classification of Kawasaki disease (KD) has been debated. Infectious disease specialists have claimed it as an infection with a classic immune responses to an as yet unidentified pathogen that localizes to the coronary arteries. Others have favored an autoreactive hypothesis that KD is triggered by an antigen that shares homology with structures in the vascular wall, and molecular mimicry resulting in an immune response directed to that tissue. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302019PMC
December 2018
1 Read

Interleukin-6 is prone to be a candidate biomarker for predicting incomplete and IVIG nonresponsive Kawasaki disease rather than coronary artery aneurysm.

Clin Exp Med 2019 Jan 8. Epub 2019 Jan 8.

Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University, No. 218 Ji-Xi Road, Hefei, 230022, People's Republic of China.

Kawasaki disease (KD) is an acute, systemic vasculitis and occurs mainly in childhood. Interleukin-6 (IL-6) is a pleiotropic cytokine synthesized predominantly by neutrophils and monocytes/macrophages and plays an important role in systemic inflammatory disease. However, a little information is currently available on the relationship of serum IL-6 with conventional inflammatory mediators, clinical classification, IVIG response and coronary artery aneurysm (CAA). Read More

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http://dx.doi.org/10.1007/s10238-018-00544-5DOI Listing
January 2019
2 Reads
2.824 Impact Factor

Diagnostic Applications for Clinical and Imaging Data in Kawasaki Disease with Lymphadenopathy-First-Presentation.

Authors:
Jae Sung Son

J Cardiovasc Imaging 2018 Dec 27;26(4):247-249. Epub 2018 Dec 27.

Department of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.4250/jcvi.2018.26.e32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310751PMC
December 2018
2 Reads

Imaging and Clinical Data Distinguish Lymphadenopathy-First-Presenting Kawasaki Disease from Bacterial Cervical Lymphadenitis.

J Cardiovasc Imaging 2018 Dec 24;26(4):238-246. Epub 2018 Dec 24.

Department of Pediatrics, Hallym University Sacred Heart Hospital, Anyang, Korea.

Background: Kawasaki disease (KD) sometimes presents with only fever and cervical lymphadenopathy before other clinical signs materialize. This lymphadenopathy-first-presenting Kawasaki disease (LKD) may be misdiagnosed as bacterial cervical lymphadenitis (BCL). We investigated characteristic imaging and clinical data for factors differentiating LKD from BCL. Read More

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http://dx.doi.org/10.4250/jcvi.2018.26.e29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310750PMC
December 2018
1 Read

Coronary artery status of patients with transient fever 24-36 h after first IVIG infusion did not differ from that seen in responsive patients.

Pediatr Rheumatol Online J 2018 Dec 29;16(1):83. Epub 2018 Dec 29.

Department of Pediatrics, University of Ulsan College of Medicine, Seoul, South Korea.

Background: Current management guidelines for patients with Kawasaki disease (KD) differ in their recommendations for fever observation times when determining resistance to initial intravenous immunoglobulin (IVIG). This retrospective study assessed coronary artery status in patients with transient fever 24-36 h after the completion of a first IVIG infusion.

Methods: Children with KD treated with IVIG between January 2006 and February 2017 were included. Read More

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http://dx.doi.org/10.1186/s12969-018-0301-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311065PMC
December 2018
3 Reads

A novel variant of torque teno virus 7 identified in patients with Kawasaki disease.

PLoS One 2018 28;13(12):e0209683. Epub 2018 Dec 28.

Department of Pediatrics, Japan Community Health Care Organization Osaka Hospital, Osaka, Japan.

Kawasaki disease (KD), first identified in 1967, is a pediatric vasculitis of unknown etiology that has an increasing incidence in Japan and many other countries. KD can cause coronary artery aneurysms. Its epidemiological characteristics, such as seasonality and clinical picture of acute systemic inflammation with prodromal intestinal/respiratory symptoms, suggest an infectious etiology for KD. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209683PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310298PMC
December 2018
8 Reads

Procalcitonin levels predicting the infliximab response of immunoglobulin resistant Kawasaki disease.

Cytokine 2018 Dec 21;114:26-31. Epub 2018 Dec 21.

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Objective: To search the predictive factors of infliximab resistance in intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) patients.

Study Design: Twenty-seven patients with KD who received infliximab after 4-5 g/kg of IVIG therapy from 2013 to 2015 were consecutively recruited in this study. They were divided into two groups: patients who responded to infliximab (infliximab-responsive group, n = 15) and patients who required additional therapy for the disease control (infliximab-resistant group, n = 12). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666183046
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http://dx.doi.org/10.1016/j.cyto.2018.11.025DOI Listing
December 2018
9 Reads

Dynamic evaluation of hemostasis in the acute phase of Kawasaki disease using comprehensive coagulation functional assays.

Thromb Res 2019 Feb 13;174:76-83. Epub 2018 Dec 13.

Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan.

Introduction: Kawasaki disease (KD) is a systemic vasculitis involving coronary arteries, sometimes resulting in aneurysms and myocardial infarction. Hyper-coagulability in the acute-phase of KD is indicated in some circumstances based on changes of individual clotting factors. Comprehensive coagulation assays, clot waveform analysis (CWA) and thrombin/plasmin generation assay (T/P-GA), have been developed to assess physiological hemostasis, but these techniques have not been applied in KD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00493848183065
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http://dx.doi.org/10.1016/j.thromres.2018.12.016DOI Listing
February 2019
15 Reads

P2RY12:rs7637803 TT variant genotype increases coronary artery aneurysm risk in Kawasaki disease in a southern Chinese population.

J Gene Med 2019 Jan 10;21(1):e3066. Epub 2019 Jan 10.

Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.

Background: Activated-platelet increases the risk of thrombosis in Kawasaki disease (KD) patients with a coronary artery aneurysm (CAA). The ADP pathway is one of the platelet activation and aggregation pathways. The P2RY12 gene encodes the ADP receptor that is highly concentrated on platelets. Read More

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http://doi.wiley.com/10.1002/jgm.3066
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http://dx.doi.org/10.1002/jgm.3066DOI Listing
January 2019
4 Reads
2.472 Impact Factor

Clinical aspects of splenomegaly as a possible predictive factor of coronary artery changes in Kawasaki disease.

Cardiol Young 2018 Dec 21:1-6. Epub 2018 Dec 21.

Department of Pediatrics, Samsung Changwon Hospital,Sungkyunkwan University School of Medicine,Changwon,Korea.

Background: Although many clinical features that are not typically included in the diagnostic criteria for Kawasaki disease, such as gall bladder hydrops, are known to occur with Kawasaki disease, splenomegaly is not concerned. We investigated the relationship of splenomegaly with the development of coronary artery lesions in Kawasaki disease.Methods and resultsThis retrospective descriptive study was conducted through a review of medical records of children with Kawasaki disease from March 2011 to February 2017. Read More

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http://dx.doi.org/10.1017/S1047951118002238DOI Listing
December 2018
2 Reads

Early features of Kawasaki disease with pyuria in febrile infants younger than 6 months.

BMC Pediatr 2018 Dec 20;18(1):389. Epub 2018 Dec 20.

Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.

Background: Children with Kawasaki disease (KD) and pyuria have been misdiagnosed with urinary tract infection (UTI). We compared clinical and laboratory features at admission between two groups of infants under 6 months of age who showed initial pyuria, to identify the initial clues suggestive of KD.

Methods: We retrospectively reviewed the medical records of children with fever who were under 6 months of age with pyuria, over a 10-year period (2007-2017). Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-018-1362-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302429PMC
December 2018
15 Reads

Molecular epidemiology of noroviruses in children under 5 years of age with acute gastroenteritis in Yaoundé, Cameroon.

J Med Virol 2018 Dec 20. Epub 2018 Dec 20.

Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.

Norovirus is a common cause of acute gastroenteritis (AGE) among children in developing countries. Limited data on the prevalence and genetic variability of norovirus are available in Cameroon, where early childhood mortality due to AGE is common. We tested 902 fecal specimens from children younger than 5 years of age hospitalized with AGE between January 2010 and December 2013. Read More

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http://dx.doi.org/10.1002/jmv.25380DOI Listing
December 2018
5 Reads

Augmented ILT3/LILRB4 Expression of Peripheral Blood Antibody Secreting Cells in the Acute-Phase of Kawasaki Disease.

Pediatr Infect Dis J 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics, Sendai Medical Center, 2-8-8 Miyagino, Sendai 983-8520, Japan.

Background: Kawasaki disease (KD) is an acute, systemic vasculitis syndrome that occurs in children. The clinical symptoms and epidemiological features of KD strongly suggest that KD is triggered by unidentified infectious agents in genetically predisposed patients. In addition, a number of studies have described the role of B cells in the development of KD. Read More

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http://dx.doi.org/10.1097/INF.0000000000002259DOI Listing
December 2018
3 Reads

A case of incomplete Kawasaki disease with extremely high serum ferritin and interleukin-18 levels.

BMC Pediatr 2018 Dec 12;18(1):386. Epub 2018 Dec 12.

Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1, Oyaguchi, Kami-cho, Itabashi-ku, Tokyo, 173-8610, Japan.

Background: The clinical features and laboratory parameters of patients with Kawasaki disease (KD) and systemic juvenile idiopathic arthritis (sJIA) occasionally overlap. Therefore, serum levels of cytokine and ferritin are used as markers to distinguish between KD and sJIA. KD patients have a high level of interleukin (IL)-6, low level of IL-18, and no elevation of the level of serum ferritin. Read More

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http://dx.doi.org/10.1186/s12887-018-1365-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291954PMC
December 2018
2 Reads

HMGB1 gene polymorphism is associated with coronary artery lesions and intravenous immunoglobulin resistance in Kawasaki disease.

Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.

Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Republic of Korea.

Objectives: Kawasaki disease (KD) is an acute systemic vasculitis of unknown aetiology that affects infants and young children. Recent reports of elevated serum high mobility group box 1 (HMGB1) level during the acute phase of KD and its relationship to poor response to IVIG treatment suggest a possible association of HMGB1 polymorphisms with KD. We investigated the association between the polymorphisms of the HMGB1 gene, KD susceptibility, coronary artery lesions, and KD response to IVIG treatment. Read More

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http://dx.doi.org/10.1093/rheumatology/key356DOI Listing
December 2018
2 Reads

Transient Q-waves in an infant with asymptomatic myocardial infarction due to Kawasaki disease.

Cardiol Young 2019 Feb 6;29(2):231-234. Epub 2018 Dec 6.

Department of Pediatrics,Shinshu University School of Medicine,Asahi 3-1-1, Matsumoto,Japan.

Giant coronary artery aneurysms are a complication of Kawasaki disease and can be fatal if associated with thrombosis. We describe the clinical outcome of a boy with Kawasaki disease who exhibited "supergiant" coronary artery aneurysms at the age of 14 months and, despite treatment with anticoagulant and antiplatelet medication, developed a left coronary artery thrombosis and presented following a myocardial infarction at 2 years old. Although his symptoms were minimal, the myocardial infarction was identified by abnormal Q-waves and giant negative T-waves in precordial leads of routine electrocardiography. Read More

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http://dx.doi.org/10.1017/S1047951118001919DOI Listing
February 2019
12 Reads

A novel model for predicting non-responsiveness to intravenous immunoglobulins in Kawasaki disease: The Singapore experience.

J Paediatr Child Health 2018 Dec 5. Epub 2018 Dec 5.

Division of Paediatric Cardiology, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore.

Aim: We aimed to assess the utility of four published risk-scoring methods in predicting intravenous immunoglobulins (IVIG) non-responsiveness in Kawasaki disease (KD) patients from Singapore and develop a new predictive model.

Methods: We reviewed the medical records of 215 KD children. The performance of existing scoring methods in identifying non-responsive cases based on sensitivities (SN) and specificities (SP) was evaluated in 122 Singaporean Chinese. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jpc.14329
Publisher Site
http://dx.doi.org/10.1111/jpc.14329DOI Listing
December 2018
15 Reads