3,196 results match your criteria Pediatrics Kawasaki Disease


The rs1051931 G>A Polymorphism in the Gene Confers Resistance to Immunoglobulin Therapy in Kawasaki Disease in a Southern Chinese Population.

Front Pediatr 2020 23;8:338. Epub 2020 Jun 23.

Department of Blood Transfusion and Clinical Lab, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, Guangzhou, China.

Kawasaki disease (KD) is a common cardiovascular disease in infants and young children, with fever, rash, and conjunctivitis as the main clinical manifestations, which can lead to the occurrence of coronary aneurysms. Intravenous immunoglobulin (IVIG) is the preferred treatment for KD patients, but 10-20% of patients are resistant to IVIG. Lipoprotein-associated phospholipase A 2 (Lp-PLA2) is a potential therapeutic target for coronary atherosclerotic heart disease, and the polymorphism of Phospholipase A2 Group VII () is closely related to the activity of Lp-PLA2, of which rs1051931 is the strongest. Read More

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http://dx.doi.org/10.3389/fped.2020.00338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324548PMC

Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study.

Lancet Child Adolesc Health 2020 Jul 9. Epub 2020 Jul 9.

Paediatric Intensive Care Unit, St Mary's Hospital, London, UK; Children's Acute Transport Service, Great Ormond Street Hospital NHS Foundation Trust and NIHR Biomedical Research Centre, London, UK.

Background: In April, 2020, clinicians in the UK observed a cluster of children with unexplained inflammation requiring admission to paediatric intensive care units (PICUs). We aimed to describe the clinical characteristics, course, management, and outcomes of patients admitted to PICUs with this condition, which is now known as paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS).

Methods: We did a multicentre observational study of children (aged <18 years), admitted to PICUs in the UK between April 1 and May 10, 2020, fulfilling the case definition of PIMS-TS published by the Royal College of Paediatrics and Child Health. Read More

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http://dx.doi.org/10.1016/S2352-4642(20)30215-7DOI Listing

PEDIATRIC INFLAMMATORY MULTISYSTEM SYNDROME WITH CENTRAL NERVOUS SYSTEM INVOLVEMENT AND HYPOCOMPLEMENTEMIA FOLLOWING SARS-COV-2 INFECTION.

Pediatr Infect Dis J 2020 Jun 24. Epub 2020 Jun 24.

Pediatric Critical Care Unit, Rambam Health Care Campus.

Pediatric inflammatory multisystem syndromes associated with Severe Acute Respiratory Syndrome Coronavirus 2 are emerging in recent reports. We describe a patient with critical illness consistent with atypical Kawasaki disease with cardiac dysfunction and abdominal involvement presenting weeks after Severe Acute Respiratory Syndrome Coronavirus 2 infection. Our patient showed unique central nervous system involvement with small vessel vasculitis and profound hypocomplementemia, both not previously reported in case descriptions and may hint at possible disease mechanisms. Read More

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http://dx.doi.org/10.1097/INF.0000000000002804DOI Listing

Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management.

Children (Basel) 2020 Jul 1;7(7). Epub 2020 Jul 1.

Department of Pediatrics, Division of Neonatology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in the multisystem inflammatory syndrome in children (MIS-C). The clinical presentation of MIS-C includes fever, severe illness, and the involvement of two or more organ systems, in combination with laboratory evidence of inflammation and laboratory or epidemiologic evidence of SARS-CoV-2 infection. Some features of MIS-C resemble Kawasaki Disease, toxic shock syndrome, and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome. Read More

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http://dx.doi.org/10.3390/children7070069DOI Listing

Kawasaki disease in the COVID-19 era: a distinct clinical phenotype?

Lancet Child Adolesc Health 2020 Jul 2. Epub 2020 Jul 2.

Children's Intensive Care Unit, KK Women's and Children's Hospital, Singapore; Duke-NUS Medical School, Singapore. Electronic address:

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http://dx.doi.org/10.1016/S2352-4642(20)30207-8DOI Listing

Emergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis.

Lancet Child Adolesc Health 2020 Jul 2. Epub 2020 Jul 2.

Department of General Paediatrics, Paediatric Internal Medicine, Rheumatology and Infectious Diseases, National Referee Centre for Rheumatic, Autoimmune and Systemic Diseases in Children, Robert Debré University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Université de Paris, UFR de Médecine Paris Nord, Paris, France; Center for Research on Inflammation, INSERM, UMR1149, Paris, France; Biology and Genetics of Bacterial Cell Wall Unit, Pasteur Institute, Paris, France. Electronic address:

Background: Kawasaki disease is an acute febrile systemic childhood vasculitis, which is suspected to be triggered by respiratory viral infections. We aimed to examine whether the ongoing COVID-19 epidemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is associated with an increase in the incidence of Kawasaki disease.

Methods: We did a quasi-experimental interrupted time series analysis over the past 15 years in a tertiary paediatric centre in the Paris region, a French epicentre of the COVID-19 outbreak. Read More

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http://dx.doi.org/10.1016/S2352-4642(20)30175-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332278PMC

Low-Molecular-Weight Heparin vs Warfarin for Thromboprophylaxis in Children with Coronary Artery Aneurysms After Kawasaki Disease: A Pragmatic Registry Trial.

Can J Cardiol 2020 Jul 1. Epub 2020 Jul 1.

Division of Cardiology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

Background: The substantial risk of thrombosis in large coronary artery aneurysms (CAAs) (maximum z-score ≥ 10) after Kawasaki disease (KD) mandates effective thromboprophylaxis. We sought to determine the effectiveness of anticoagulation (low-molecular-weight heparin [LMWH] or warfarin) for thromboprophylaxis in large CAAs.

Methods: Data from 383 patients enrolled in the International KD Registry (IKDR) were used. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.01.016DOI Listing

Reply.

J Pediatr 2020 Jun 30. Epub 2020 Jun 30.

Department of Pediatrics, Rady Children's Hospital, University of California San Diego, San Diego, CA USA.

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http://dx.doi.org/10.1016/j.jpeds.2020.06.072DOI Listing

Anakinra And Etanercept Combination Treatment in a Child With Severe, Nonresponsive Kawasaki Disease.

Pediatr Infect Dis J 2020 Jun 30. Epub 2020 Jun 30.

From the Department of Pediatric Cardiology and Pediatric Intensive Care, Ludwig-Maximilians-University of Munich, Marchioninistr. 15, 81377 Munich, Germany.

Kawasaki disease (KD) patients' resistance to treatment with intravenous immunoglobulins (IVIG) places them at high risk for an unfavorable progression of the disease. In these patients, there has been little evidence that alternative treatments are effective. Nevertheless, biologicals such as an interleukin-1-receptor blocker and tumor-necrosis-factor-α inhibitors increasingly have been used. Read More

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http://dx.doi.org/10.1097/INF.0000000000002810DOI Listing

A case of Kawasaki disease with intussusception.

J Nippon Med Sch 2020 Jun 30. Epub 2020 Jun 30.

Department of Pediatrics, Nippon Medical School Hospital.

Kawasaki disease is a systemic vasculitis of unknown etiology and is known to be associated with various digestive disorders, though only a few cases of intussusception associated with Kawasaki disease have been reported. The case of a 3-year-old boy with intussusception followed by Kawasaki disease is reported. The patient was admitted to our hospital due to severe abdominal pain. Read More

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http://dx.doi.org/10.1272/jnms.JNMS.2020_87-606DOI Listing

Tribute to Dr. Tomisaku Kawasaki - Discoverer of Kawasaki Disease and a Great Pediatrician.

Authors:
Hirohisa Kato

Circ J 2020 Jul 2. Epub 2020 Jul 2.

Emeritus Professor of Pediatrics and Child Health, Kurume University.

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http://dx.doi.org/10.1253/circj.CJ-66-0180DOI Listing

Weather condition, air pollutants, and epidemics as factors that potentially influence the development of Kawasaki disease.

Sci Total Environ 2020 Jun 23;741:140469. Epub 2020 Jun 23.

Department of Pediatrics, National Hospital Organization Beppu Medical Center, 1473 Oaza-Uchikamado, Beppu, Oita 874-0011, Japan. Electronic address:

Environmental factors have been suspected to have effects on the development of Kawasaki disease. However, the associations have been conflicting. The aim of this study was to investigate the effects of air pollution, weather conditions, and epidemic infections on the risks for Kawasaki disease in Japan. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140469DOI Listing

Nationwide survey of systemic chronic active EBV infection in Japan in accordance with the new WHO classification.

Blood Adv 2020 Jul;4(13):2918-2926

Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan.

Systemic chronic active Epstein-Barr virus infection (sCAEBV) was defined as a T- or NK-cell neoplasm in the 2017 World Health Organization (WHO) classification. To clarify the clinical features of sCAEBV under this classification and review the effects of chemotherapy, we performed a nationwide survey in Japan from 2016 through 2018 of patients with sCAEBV newly diagnosed from January 2003 through March 2016. One hundred cases were evaluated. Read More

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http://dx.doi.org/10.1182/bloodadvances.2020001451DOI Listing

Reduced Platelet miR-223 Induction in Kawasaki Disease Leads To Severe Coronary Artery Pathology Through a miR-223/PDGFRβ Vascular Smooth Muscle Cell Axis.

Circ Res 2020 Jun 29. Epub 2020 Jun 29.

Institute of Pediatrics, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, CHINA.

Kawasaki disease (KD) is an acute vasculitis of early childhood that can result in per-manent coronary artery structural damage. The etiology for this arterial vulnerability in up to 15% of KD patients is unknown. Vascular smooth muscle cell (VSMC) dedifferentiation play a key role in the pathophysiology of medial damage and aneurysm formation, recognized arterial pathology in KD. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.120.316951DOI Listing
June 2020
11.019 Impact Factor

Erratum: Significance of Differential Characteristics in Infantile Kawasaki Disease.

Korean Circ J 2020 Jul;50(7):641-643

Department of Pediatrics, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.

This corrects the article on p. 755 in vol. 49, PMID: 31074226. Read More

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http://dx.doi.org/10.4070/kcj.2020.0999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321749PMC

A case of Kawasaki disease complicated by acute disseminated encephalitis.

Pediatr Int 2020 Jun 26. Epub 2020 Jun 26.

Department of Pediatrics, Jichi Medical University, Tochigi, Japan.

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http://dx.doi.org/10.1111/ped.14234DOI Listing

Multisystem Inflammatory Syndrome in Children and Kawasaki Disease: Two Different Illnesses with Overlapping Clinical Features.

Authors:
Anne H Rowley

J Pediatr 2020 Jun 22. Epub 2020 Jun 22.

Department of Pediatrics and of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, The Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2020.06.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308002PMC

Human and novel coronavirus infections in children: a review.

Paediatr Int Child Health 2020 Jun 25:1-20. Epub 2020 Jun 25.

Division of Infectious Diseases, Department of Pediatrics and Internal Medicine, University of Saskatchewan , Saskatoon, Saskatchewan, Canada.

Coronaviruses, seven of which are known to infect humans, can cause a spectrum of clinical presentations ranging from asymptomatic infection to severe illness and death. Four human coronaviruses (hCoVs)-229E, HKU1, NL63 and OC43-circulate globally, commonly infect children and typically cause mild upper respiratory tract infections. Three novel coronaviruses of zoonotic origin have emerged during the past two decades: severe acute respiratory syndrome coronavirus (SARS-CoV-1), Middle East respiratory syndrome coronavirus (MERS-CoV) and the recently discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is the cause of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Read More

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http://dx.doi.org/10.1080/20469047.2020.1781356DOI Listing

COVID-19-associated Hemophagocytic Lymphohistiocytosis and Coagulopathy: Targeting the Duumvirate.

Indian Pediatr 2020 Jun 24. Epub 2020 Jun 24.

Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Context: Preliminary data on coexistence of secondary hemophagocytic lymphohistiocytosis syndrome (HLH) and disseminated intravascular coagulation (DIC) in critically ill children with novel coronavirus disease (COVID-19) are emerging. Herein, we summarize the available literature and fill-in the gaps in this regard.

Evidence Acquisition: We have performed a literature search for articles in PubMed, EMBASE and Google Scholar databases till May 12, 2020, with following keywords: "COVID-19", "SARS-CoV-2", "HLH", "HScore", "coagulopathy", "D-dimer", "cytokine storm", "children" and "pediatrics" with interposition of Boolean operator "AND". Read More

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A Case of Pediatric Multisystem Inflammatory Syndrome Temporally Associated with COVID-19 in South Dakota.

S D Med 2020 Jun;73(6):246-251

Department of Pediatrics and Pediatric Critical Care, Avera McKennan Children's Hospital and University Health Center.

Coronavirus infectious disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was deemed a worldwide pandemic by the World Health Organization in February 2020. The U.S. Read More

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Serology confirms SARS-CoV-2 infection in PCR-negative children presenting with Paediatric Inflammatory Multi-System Syndrome.

medRxiv 2020 Jun 7. Epub 2020 Jun 7.

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, U.K.

Background: During the COVID-19 outbreak, reports have surfaced of children who present with features of a multisystem inflammatory syndrome with overlapping features of Kawasaki disease and toxic shock syndrome - Paediatric Inflammatory Multisystem Syndrome- temporally associated with SARS-CoV-2 pandemic (PIMS-TS). Initial reports find that many of the children are PCR-negative for SARS-CoV-2, so it is difficult to confirm whether this syndrome is a late complication of viral infection in an age group largely spared the worst consequences of this infection, or if this syndrome reflects enhanced surveillance.

Methods: Children hospitalised for symptoms consistent with PIMS-TS between 28 April and 8 May 2020, and who were PCR-negative for SARS-CoV-2, were tested for antibodies to viral spike glycoprotein using an ELISA test. Read More

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http://dx.doi.org/10.1101/2020.06.05.20123117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302282PMC

[Association of rs4638289 and rs7131332 polymorphisms of the serum amyloid A1 gene with Kawasaki disease].

Zhongguo Dang Dai Er Ke Za Zhi 2020 Jun;22(6):614-619

Department of Pediatrics, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Zhuzhou, Hunan 412000, China.

Objective: To study the association of the polymorphisms of the serum amyloid A1 (SAA1) gene at rs4638289 and rs7131332 loci with Kawasaki disease (KD) and its complication coronary artery lesion (CAL) in children.

Methods: A total of 105 Han children with KD who were hospitalized and treated from 2013 to 2017 were enrolled as the KD group. A total of 100 Han children who underwent physical examination were enrolled as the control group. Read More

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Another Compelling Evidence Suggesting Infectious Diseases as the Cause of Kawasaki Disease?

Authors:
Chou-Cheng Lai

J Chin Med Assoc 2020 Jun 15. Epub 2020 Jun 15.

Department of Pediatrics, National Yang-Ming University, Taipei, Taiwan, ROC.

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http://dx.doi.org/10.1097/JCMA.0000000000000373DOI Listing

Kawasaki Disease and Acute Kidney Injury in Pediatric Patients.

Indian J Pediatr 2020 Jun 17. Epub 2020 Jun 17.

Department of Pediatric Rheumatology, Hospital del Niño "Dr. Federico Gómez Santos", Saltillo, Coahuila, Mexico.

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http://dx.doi.org/10.1007/s12098-020-03404-xDOI Listing

Long-term follow-up of coronary artery lesions in children in Kawasaki syndrome.

Eur J Pediatr 2020 Jun 15. Epub 2020 Jun 15.

Rheumatology Unit, A. Meyer Children's University Hospital, University of Florence, Florence, Italy.

To describe clinical and epidemiological characteristics of a Kawasaki syndrome cohort. In a monocentric, retrospective, observational study, between February 1982 and August 2018, we enrolled 361 children, aged 1 month to 24.4 years. Read More

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http://dx.doi.org/10.1007/s00431-020-03712-6DOI Listing

Characteristics, Cardiac involvement, and Outcomes of Multisystem Inflammatory Disease of Childhood (MIS-C) Associated with SARS-CoV-2 Infection.

J Pediatr 2020 Jun 14. Epub 2020 Jun 14.

Department of Pediatrics, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, NY; Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY.

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http://dx.doi.org/10.1016/j.jpeds.2020.06.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293762PMC

Assessment of Platelet Thrombus Formation under Flow Conditions in Patients with Acute Kawasaki Disease.

J Pediatr 2020 Jun 14. Epub 2020 Jun 14.

Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan.

Objective: To assess platelet thrombus formation (T-TAS) under flow conditions in patients with Kawasaki disease. Previously available platelet activation data were limited for non-physiological shear stress condition. The total thrombus-formation analysis system (T-TAS®) was developed for quantitative PTF analysis. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.06.025DOI Listing

CT Coronary Angiography Studies After a Mean Follow-up of 3.8 Years in Children With Kawasaki Disease and Spontaneous Defervescence.

Front Pediatr 2020 28;8:274. Epub 2020 May 28.

Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

There is paucity of literature on follow-up of children with Kawasaki disease (KD) who have spontaneous defervescence during the acute stage and do not receive intravenous immunoglobulin. We report herein the role of computed tomography coronary angiography (CTCA) as an imaging modality in such situations. This prospective observational study was carried out during the period January 2016-June 2017. Read More

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http://dx.doi.org/10.3389/fped.2020.00274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270275PMC

Kawasaki Disease Features and Myocarditis in a Patient with COVID-19.

Pediatr Cardiol 2020 Jun 15. Epub 2020 Jun 15.

Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.

A 10-year-old male with prolonged fever, rash, and conjunctivitis presented to the emergency department with concern for Kawasaki disease, found to have myocarditis and PCR positive for SARS-CoV-2. Read More

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http://dx.doi.org/10.1007/s00246-020-02393-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295325PMC

A 9-year-old girl with Kawasaki disease and pulmonary nodules.

Clin Rheumatol 2020 Jun 12. Epub 2020 Jun 12.

Department of Pediatrics, National Hospital Organization Okayama Medical Center, 1711-1, Tamasu, Kita-ku, Okayama, Okayama, 701-1192, Japan.

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http://dx.doi.org/10.1007/s10067-020-05222-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290145PMC

Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital.

Pediatr Cardiol 2020 Jun 12. Epub 2020 Jun 12.

Department of Cardiology, Birmingham Women's and Children's NHS Foundation Trust, Steelhouse Lane, Birmingham, B4 6NH, UK.

Children were relatively spared during COVID-19 pandemic. However, the recently reported hyperinflammatory syndrome with overlapping features of Kawasaki disease and toxic shock syndrome-"Paediatric Inflammatory Multisystem Syndrome-temporally associated with SARS-CoV-2" (PIMS-TS) has caused concern. We describe cardiac findings and short-term outcomes in children with PIMS-TS at a tertiary children's hospital. Read More

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http://dx.doi.org/10.1007/s00246-020-02391-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289638PMC

Familial Kawasaki disease and acute glomerulonephritis: case report and review of literature.

Sudan J Paediatr 2020 ;20(1):68-72

Mohamed Alamin Hamid Hospital for Children, Omdurman, Sudan.

We report two siblings, a 6-year-old boy and his 4-year-old sister who were admitted with fever for 15 days and features of Kawasaki disease. After admission to the hospital, both patients developed red urine and headache. Blood pressure was found to be high in relation to blood pressure percentiles for both patients. Read More

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http://dx.doi.org/10.24911/SJP.106-1548975790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282432PMC
January 2020

Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort.

Ann Rheum Dis 2020 Jun 11. Epub 2020 Jun 11.

General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris, France

Background: Current data suggest that COVID-19 is less frequent in children, with a milder course. However, over the past weeks, an increase in the number of children presenting to hospitals in the greater Paris region with a phenotype resembling Kawasaki disease (KD) has led to an alert by the French national health authorities.

Methods: Multicentre compilation of patients with KD in Paris region since April 2020, associated with the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ('Kawa-COVID-19'). Read More

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http://dx.doi.org/10.1136/annrheumdis-2020-217960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299653PMC

Kawasaki disease: Shedding light on a mysterious diagnosis.

JAAPA 2020 Jul;33(7):18-22

At the time this article was written, Jana Galuppo and Alexandra Kowker were students in the PA program at the University of Lynchburg in Lynchburg, Va. Ms. Galuppo now practices at Centra Medical Group Neurology Center in Lynchburg, Va. Ms. Kowker practices in pediatrics at Johnson Health Center in Lynchburg, Va. At the University of Lynchburg, Jenna Rolfs is program director and an assistant professor, Joyce Nicholas is director of evaluation, assessment, and compliance and a professor, and Eric Schmidt is an assistant professor. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Kawasaki disease is an acute systemic febrile vasculitis of medium and small arteries, most often occurring in children under age 5 years. This condition is the most common cause of acquired heart disease in children in the developed world. The cause is unclear but is thought to be a hyperimmune reaction to an infectious agent. Read More

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http://dx.doi.org/10.1097/01.JAA.0000668792.41976.f2DOI Listing

Cardiac MRI of Children with Multisystem Inflammatory Syndrome (MIS-C) Associated with COVID-19: Case Series.

Radiology 2020 Jun 9:202288. Epub 2020 Jun 9.

From the Department of imaging, Hôpital Trousseau - Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (E.B., C.S., H.D.L.P.), Laboratoire d'Imagerie Biomédicale, Sorbonne Université, INSERM, CNRS, Paris, France (E.B., A.R.), Pediatric cardiovascular Unit, Hôpital Trousseau - Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (P.P., A.R.), Department of Cardiovascular and Thoracic Imaging and Interventional Radiology, Institute of Cardiology, Hôpital Pitié-Salpêtrière - Assistance Publique-Hôpitaux Parisiens (AP-HP) Sorbonne Université, Paris, France (A.R.), Neonatal and Pediatric Intensive Care Unit, Hôpital Trousseau - Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (L.T., Y.L.), Laboratoire INSERM U955- PHYDES-IMRB - Stratégies pharmacologiques et thérapeutiques de l'ischémie myocardique et l'insuffisance coronaire- Ecole Vétérinaire, Maisons-Alfort (Y.L.), Laboratoire de virologie, Hôpital Trousseau - Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (A.S.), Department of Pediatrics, Hôpital Trousseau - Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (M.L.), Pediatric Emergency Department, Hôpital Trousseau - Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (R.G.).

This case series examines cardiac MRI findings in four children and adolescents admitted to intensive care in April 2020 for multisystem inflammatory syndrome and Kawasaki disease-like features related to COVID-19. Acute myocarditis occurred less than 1 week after onset of fever and gastrointestinal symptoms. Physical examination showed rash and cheilitis/conjunctivitis. Read More

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http://dx.doi.org/10.1148/radiol.2020202288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294821PMC

An uncommon overlap of two common rheumatological disorders.

Lupus 2020 Jun 9:961203320930101. Epub 2020 Jun 9.

Advanced Pediatrics Centre, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Juvenile systemic lupus erythematosus (SLE) is a heterogeneous multisystem autoimmune disease. Kawasaki disease is a common vasculitic disorder in children that manifests with fever and mucocutaneous involvement. While overlap of childhood SLE with other rheumatological disorders has been described, it is extremely unusual in the context of Kawasaki disease. Read More

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http://dx.doi.org/10.1177/0961203320930101DOI Listing
June 2020
2.197 Impact Factor

Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2.

JAMA 2020 Jun 8. Epub 2020 Jun 8.

Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, London, United Kingdom.

Importance: In communities with high rates of coronavirus disease 2019, reports have emerged of children with an unusual syndrome of fever and inflammation.

Objectives: To describe the clinical and laboratory characteristics of hospitalized children who met criteria for the pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PIMS-TS) and compare these characteristics with other pediatric inflammatory disorders.

Design, Setting, And Participants: Case series of 58 children from 8 hospitals in England admitted between March 23 and May 16, 2020, with persistent fever and laboratory evidence of inflammation meeting published definitions for PIMS-TS. Read More

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http://dx.doi.org/10.1001/jama.2020.10369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281356PMC

SARS-CoV-2-Related Inflammatory Multisystem Syndrome in Children: Different or Shared Etiology and Pathophysiology as Kawasaki Disease?

JAMA 2020 Jun 8. Epub 2020 Jun 8.

Johns Hopkins University School of Medicine, Division of Cardiology, Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1001/jama.2020.10370DOI Listing

Outcomes of Kawasaki disease with giant coronary aneurysms: a single-centre study in southwest China.

Cardiol Young 2020 Jun 8;30(6):834-839. Epub 2020 Jun 8.

Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Autonomous Region, PR China.

Background: Giant coronary aneurysms are the most severe complications of Kawasaki disease. There are few reports of outcomes from China. Most previous studies were based only on absolute aneurysmal dimensions. Read More

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http://dx.doi.org/10.1017/S1047951120001134DOI Listing

Defining Association between COVID-19 and the Multisystem Inflammatory Syndrome in Children through the Pandemic.

J Korean Med Sci 2020 06 8;35(22):e204. Epub 2020 Jun 8.

Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3346/jkms.2020.35.e204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279946PMC
June 2020
1.253 Impact Factor

Outcomes in Kawasaki disease patients with coronary artery abnormalities at admission.

Am Heart J 2020 07 3;225:120-128. Epub 2020 May 3.

Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA.

Background: Previous studies demonstrated that coronary artery lesions (CALs) resulting from Kawasaki disease (KD) can improve over time. However, limited information is available on sub-acute outcomes of CALs detected at admission during KD illness.

Methods: The nationwide Japanese KD survey contained substantial information on KD patients with CALs detected at admission and who received standard IVIG treatment within 10 days of disease onset. Read More

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http://dx.doi.org/10.1016/j.ahj.2020.04.019DOI Listing
July 2020
4.463 Impact Factor

Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study.

BMJ 2020 06 3;369:m2094. Epub 2020 Jun 3.

Department of General Paediatrics and Paediatric Infectious Diseases, Necker-Enfants Malades University Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université de Paris, 149 rue de Sèvres, 75015 Paris, France.

Objectives: To describe the characteristics of children and adolescents affected by an outbreak of Kawasaki-like multisystem inflammatory syndrome and to evaluate a potential temporal association with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Design: Prospective observational study.

Setting: General paediatric department of a university hospital in Paris, France. Read More

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http://dx.doi.org/10.1136/bmj.m2094DOI Listing

Correlation of gut microbial compositions to the development of Kawasaki disease vasculitis in children.

Future Microbiol 2020 May 3;15:591-600. Epub 2020 Jun 3.

State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science & Technology, Macau SAR, China.

Here, we hypothesize that dysbiotic gut microbiota might contribute to the development of Kawasaki disease (KD), a pediatric disease with unknown etiology. This is the second report on gut microbiota composition in KD patients. 16S amplicon sequencing was performed on fecal DNA samples and revealed predominance of bacterial pathogens, such as , ,  and , in the gut of KD patients, but absent or suppressed after immunoglobulin/antibiotics therapy. Read More

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http://dx.doi.org/10.2217/fmb-2019-0301DOI Listing

Mapping the Trends of Kawasaki Disease in Hawai'i from 1996 to 2018.

Hawaii J Health Soc Welf 2020 May;79(5 Suppl 1):104-111

Department of Pediatrics, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI (MM, AB).

Kawasaki disease is a systemic vasculitis of unknown etiology and is the leading cause of acquired heart disease in children in the developed world. Historically, Hawai'i has had the highest incidence of Kawasaki disease in the United States, likely due to the population's unique ancestral composition. To analyze the epidemiology, demographics and spatiotemporal distribution of Kawasaki disease in Hawai'i, a retrospective chart review was conducted utilizing data from Kapi'olani Medical Center for Women and Children encompassing the period of 1996-2018. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260882PMC

Aspirin Dose and Treatment Outcomes in Kawasaki Disease: A Historical Control Study in Japan.

Front Pediatr 2020 14;8:249. Epub 2020 May 14.

Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center, Chiba, Japan.

Aspirin has been used as a concomitant drug in the treatment of Kawasaki disease (KD). In recent years, there has been discussion concerning whether high-dose aspirin is appropriate for treatment in the acute phase of KD. We retrospectively investigated the incidence of coronary artery abnormalities (CAAs) and the antipyretic effect of 30 to 50 mg/kg/day aspirin, the minimum and the maximum approved doses in Japan. Read More

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http://dx.doi.org/10.3389/fped.2020.00249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241278PMC

Indian Academy of Pediatrics Position Paper on Kawasaki Disease.

Indian Pediatr 2020 May 28. Epub 2020 May 28.

AJ Institute of Medical Sciences, Mangalore, Karnataka; India.

Objectives: To formulate practice guidelines on diagnosis and management of Kawasaki disease (KD) for Indian children.

Justification: KD is a systemic vasculitis that predominantly affects infants and children less than 5 years of age. Coronary artery abnormalities (CAA) develop in around 15-25% of untreated children with KD. Read More

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Blood Mercury Levels in Children with Kawasaki Disease and Disease Outcome.

Int J Environ Res Public Health 2020 May 25;17(10). Epub 2020 May 25.

Department of Pediatrics and Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.

The risk of ethnic Kawasaki disease (KD) has been proposed to be associated with blood mercury levels in American children. We investigated the blood levels of mercury in children with KD and their association with disease outcome. The mercury levels demonstrated a significantly negative correlation with sodium levels ( = 0. Read More

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http://dx.doi.org/10.3390/ijerph17103726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277186PMC

COVID-19 and Kawasaki disease in children.

Pharmacol Res 2020 May 25;159:104951. Epub 2020 May 25.

Department of Endocrinology and Metabolism, The First Affiliated Hospital, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, 230037, China. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2020.104951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247462PMC

Multisystem Inflammatory Syndrome with Features of Atypical Kawasaki Disease during COVID-19 Pandemic.

Indian J Pediatr 2020 May 28. Epub 2020 May 28.

Department of Pediatrics, Santi Hospital, Omassery, Calicut, Kerala, India.

There is a global concern of increasing number of children presenting with inflammatory syndrome with clinical features simulating Kawasaki disease, during ongoing COVID-19 pandemic. The authors report a very similar case of 5-y-old boy from a COVID-19 hotspot area who presented in late April 2020 with acute febrile illness with abdominal pain and loose stools followed by shock. On examination, child had bulbar conjunctivitis and extremity edema. Read More

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http://dx.doi.org/10.1007/s12098-020-03357-1DOI Listing
May 2020
0.919 Impact Factor