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Pediatrics 2019 Feb 12. Epub 2019 Feb 12.

Divisions of Emergency Medicine and.

A 2-year-old girl with a past medical history of cutaneous mastocytosis and eczema presented with 1 day of yellow-green, nonbloody vomiting, bradycardia, and listlessness. She was evaluated by her pediatrician and sent to the emergency department because of concern for dehydration. In the emergency department, she improved with fluid rehydration but still had decreased energy and bradycardia. Read More

J Pediatr Health Care 2019 Jan 16. Epub 2019 Jan 16.

Pediatr Emerg Care 2019 Jan;35(1):72-74

Department of Radiology, Faculty of Medicine, University of Toronto.

Diagnostic dilemmas are ubiquitous in pediatric emergency medicine because of the varied and often insidious presentations of many pediatric conditions. Point-of-care ultrasound (POCUS) in emergency departments is being used for some of these diagnostic challenges and can often provide rapid and valuable information to supplement a physician's clinical assessment. Intussusception is a pediatric condition that may be challenging to recognize because of its subtle and varied presenting symptoms. Read More

J Pediatr Gastroenterol Nutr 2018 Dec 19. Epub 2018 Dec 19.

St Mark's Hospital Polyposis Registry UK.

Peutz-jeghers syndrome (PJS) is a well-described inherited syndrome, characterised by the development of gastrointestinal polyps and characteristic mucocutaneous freckling. Development of small bowel intestinal polyps may lead to intussusception in children may require emergency laparotomy with potential loss of bowel. Gastrointestinal (GI) polyps may lead to bleeding and anaemia. Read More

Pediatr Int 2018 Dec 19. Epub 2018 Dec 19.

Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.

Children with cancer are at increased risk of life-threatening emergencies, either from the cancer itself or related to the cancer treatment. These conditions need to be assessed and treated as early as possible to minimize morbidity and mortality. Cardiothoracic emergencies encompass a variety of pathologies, including pericardial effusion and cardiac tamponade, massive hemoptysis, superior vena cava syndrome, pulmonary embolism, and pneumonia. Read More

J Clin Ultrasound 2019 Feb 14;47(2):97-99. Epub 2018 Dec 14.

Department of Ultrasound, Qilu Children's Hospital of Shandong University, Jinan, PR China.

An ileal adenomyoma leading to intussusception is very rare. We describe the case of a 4-month-old boy who presented with hematochezia. He was diagnosed with ileal adenomyoma by sonography, which was confirmed by histopathology. Read More

Vaccine 2018 Nov 7;36(50):7593-7598. Epub 2018 Nov 7.

Centers for Disease Control and Prevention, Atlanta, USA.

Intussusception is the invagination of one segment of the bowel into a distal segment, characterized by symptoms of bloody stool, vomiting, and abdominal pain. Previous studies have found regional differences in incidence but the etiology of most intussusception cases is unknown. Rotavirus vaccines were associated with a slightly of increased risk of intussusception in post-licensure evaluations in high- and middle-income countries, but not in low income African countries. Read More

Forensic Sci Med Pathol 2018 Nov 5. Epub 2018 Nov 5.

Institute of Forensic Medicine "Milovan Milovanović", University of Belgrade - School of Medicine, 31a Deligradska str., Belgrade, 11000, Serbia.

Intussusception is one of the most common causes of intestinal obstructions in younger children, especially infants. Though rare, fatalities due to intussusception are known to be caused by intestinal obstruction associated with peritonitis, generalized sepsis and shock from intestinal infarction due to disruption in blood supply or electrolyte and fluid imbalance. An eight-month-old female infant, who initially presented with a single episode of vomiting and fever (37. Read More

Pan Afr Med J 2018 11;30:105. Epub 2018 Jun 11.

Service de Chirurgie Viscérale, Hôpital Militaire Mouly Ismail Meknes, Maroc.

Intussusception is a very common condition in pediatrics, while in adults it is rare and accounts for only 10% of intussusceptions and 4% of intestinal occlusions. Colonic lymphoma revealed by intussusception is a very rare disease. We report the case of a 21-year old woman admitted with intestinal subocclusion to the Emergency Department at the Military Hospital Moulay Ismail, Meknes Morocco. Read More

J Pediatr Surg 2018 Sep 25. Epub 2018 Sep 25.

Department of Surgery, Children's Mercy Hospital, Kansas City, MO 64108. Electronic address:

Purpose: Pediatric intussusception's first line treatment consists of fluoroscopic guided air enema reduction. Postprocedure, these patients are usually admitted overnight for observation. The purpose of our study was to document the results of emergency department (ED) observation and discharge protocol after successful reduction of ileocolic intussusception. Read More

J Microbiol Immunol Infect 2018 Sep 24. Epub 2018 Sep 24.

Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-Kung road, Neihu, Taipei, Taiwan. Electronic address:

Bacterial enteritis has been reported to be a risk factor for childhood intussusception. However, no case report concerning children with concurrent Campylobactor bacteremia and intussusception were found in the literature. Herein, we report a 5-year-old male preschool child who presented symptoms of infectious diarrhea, and ileocecal type intussuscepton and Campylobactor jejuni bacteremia were found after a series of investigations. Read More

Balkan Med J 2019 01 5;36(1):66-67. Epub 2018 Oct 5.

Department for Health Studies, University of Zadar, Zadar, Croatia

J Emerg Med 2018 Nov 28;55(5):e125-e127. Epub 2018 Sep 28.

Emergency Department, Naval Medical Center San Diego, San Diego, California.

Background: Autoamputation of the appendix is a condition associated with the Ladd's procedure, a pediatric surgical technique for correction of intestinal malrotation. A 4-year-old male patient with a history of a Ladd's procedure performed as a newborn was brought in by his mother for "passing intestine" just prior to arrival. She reported that for several weeks her son had intermittent, crampy abdominal pain that resolved after the unusual-appearing bowel movement. Read More

ANZ J Surg 2018 Aug 22. Epub 2018 Aug 22.

Department of Paediatric Surgery, Urology and Surgical Simulation, Monash Children's Hospital, Melbourne, Victoria, Australia.

Background: Intussusception is a common, potentially life-threatening paediatric condition. Non-operative treatment with an air enema has been established as the clinical gold standard. There is no validated model for the training of this procedure. Read More

Iran J Med Sci 2018 Jul;43(4):432-435

Department of Pediatrics, CSI Kalyani Multispeciality Hospital, Mylapore, Chennai, India.

Ascariasis is a common worm infestation in developing and under-developed countries. It is caused by the ingestion of food contaminated with Ascaris eggs from faeces and is more common in places with poor sanitation. Almost 25% of the world population is infested by Ascaris lumbricoides. Read More

Sci Rep 2018 Jul 25;8(1):11194. Epub 2018 Jul 25.

Murdoch Children's Research Institute, Melbourne, Victoria, Australia.

In 2012, Fiji introduced rotavirus vaccine (Rotarix, GSK) into the national immunisation schedule. We describe the intussusception epidemiology prior to rotavirus vaccine, temporal association of intussusception cases to administration of rotavirus vaccine, and estimate the additional number of intussusception cases that may be associated with rotavirus vaccine. A retrospective review of intussusception cases for children aged <24 months old was undertaken between January 2007 and October 2012 pre-vaccine. Read More

ACG Case Rep J 2018 18;5:e53. Epub 2018 Jul 18.

Department of Pediatrics, University of Campinas School of Medical Sciences, Campinas, São Paulo, Brazil.

Distal intestinal obstruction syndrome (DIOS) is a relatively common intestinal complication in cystic fibrosis (CF), and it can eventually lead to intussusception, a less frequent complication in CF. Intussusception is classically associated with gastrointestinal symptoms that overlap those of DIOS. We describe a young woman with oligosymptomatic intussusception diagnosed after resolution of DIOS symptoms. Read More

Arch Argent Pediatr 2018 Aug;116(4):e599-e602

Department of Pediatrics, Allergology and Gastroenterology CM Bydgoszcz, NCU Torun, Poland.

Bloody diarrhea is a common problem in early childhood, typically caused by anal fissures, infectious enteritis, allergic proctocolitis, swallowed maternal blood and intussusception. More rarely, it can also be caused by volvulus, coagulopathies, necrotizing enterocolitis, polyps, Meckel diverticulitis and inflammatory bowel disease (IBD). The incidence of IBD is on the rise in children, even affecting infants. Read More

Cardiol Young 2018 Aug 2;28(8):1070-1073. Epub 2018 Jul 2.

3Department of Pediatric Cardiology,Ankara Yuksek İhtisas Education and Research Hospital,Ankara,Turkey.

Kawasaki disease is an acute febrile multisystem vasculitis. The term Incomplete Kawasaki disease is used in the presence of a minimum of two diagnostic criteria of clinical Kawasaki syndrome accompanied by at least 5 days of fever, the absence of any other reasons characterising the disease, and the presence of severe systemic inflammation findings. Gastrointestinal symptoms, notably diarrhoea, abdominal pain, and vomiting, frequently occur, and elevated serum aminotransferases, gallbladder hydrops, and rarely other forms of gastrointestinal involvement such as ischaemic colitis, intussusception, hepatic necrosis, splenic infarct, intestinal pseudo-obstruction, colitis, and colon oedema are also reported. Read More

J Korean Med Sci 2018 Jun 14;33(25):e174. Epub 2018 May 14.

Department of Pediatrics, Inje University College of Medicine, Seoul, Korea.

Background: Henoch-Schӧnlein purpura (HSP) is a common vasculitis of childhood. Though HSP is usually self-limiting, severe complications can occur. The management for this condition has not been established yet. Read More

Surg Radiol Anat 2018 Aug 21;40(8):963-965. Epub 2018 May 21.

Service de Chirurgie Infantile, Hôpital de la Timone, 13005, Marseille Cedex 20, France.

Ectopic pancreas also known as heterotopic pancreas (HP) is a rare congenital anomaly, mainly found as incidental finding during autopsy or abdominal exploration for an other condition. Incidence rate is probably underestimated as patients are mostly asymptomatic; otherwise, it is capable of producing symptoms depending on its location, size, often appearing in the 4th-to-6th decades. Complications such as inflammation, obstruction, bleeding, and malignancy degeneration must be considered. Read More

Paediatr Child Health 2018 May 3;23(3):173-175. Epub 2018 Feb 3.

Division of Paediatric Medicine, Department of Paediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario.

J Surg Case Rep 2018 May 14;2018(5):rjy090. Epub 2018 May 14.

Department of Radiology, Otsu Red Cross Hospital, Otsu, Japan.

Gastrointestinal Burkitt lymphoma (BL) is a highly aggressive malignancy in childhood, and early treatment is critical for its favorable prognosis. Ultrasonography is a widely accepted initial imaging workup; therefore, recognition of the sonographic features of BL should contribute to its early diagnosis and initiation of treatment. We present a 4-year-old boy with primary jejunal BL with intussusception mimicking presentation, in which initial abdominal US allowed sustainable detection and characterization of the intestinal lesion. Read More

Arch Dis Child 2018 Apr 26. Epub 2018 Apr 26.

Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

N Engl J Med 2018 Apr;378(16):1521-1528

From the Centers for Disease Control and Prevention, Atlanta (J.E.T., M.M.C., B.A.L., C.Y., H.G., U.D.P.); the World Health Organization (WHO) Regional Office for Africa, Brazzaville, Republic of Congo (J.M.M., R.M., F.R.Z., R.M.M.); the Noguchi Memorial Institute for Medical Research (G.A.) and the School of Medicine and Dentistry, College of Health Sciences (C.E.-L.), University of Ghana, and Korle Bu Teaching Hospital (H.G.-A.), Accra, Komfo Anokye Teaching Hospital, Kumasi (D.A.), and the School of Public Health, University of Health and Allied Sciences, Hohoe (C.T.N.) - all in Ghana; the WHO Country Office (B.J.) and Muhimbili National Hospital (M.M.), Dar es Salaam, Kilimanjaro Christian Medical Center, Moshi (D.M.), and Mbeya Zonal Referral Hospital, Mbeya (L.M.) - all in Tanzania; Kenya Medical Research Institute, Center for Global Health Research, Kisumu (R.O., B.O.), the Department of Surgery, School of Medicine, University of Nairobi, Nairobi (F.O.), and the School of Medicine, Moi University, Eldoret (P.S.) - all in Kenya; the WHO Country Office (A.A., T.K., F.T.) and the School of Medicine, Addis Ababa University (A.T.), Addis Ababa, Ethiopia; Harare Central Hospital (H.M., B.M.), the Department of Pediatrics and Child Health, University of Zimbabwe (H.M.), the WHO Intercountry Support Team (G.W.), and Epidemiology and Disease Control, Ministry of Health and Child Care (P.M.), Harare, Zimbabwe; the Children's Hospital (E.M.), Adult Hospital, Virology Laboratory (J.S.), and Adult Hospital, Department of Surgery, Pediatric Surgical Unit (B.B.), University Teaching Hospitals, Lusaka, Zambia; the College of Medicine, University of Malawi, Blantyre (B.N.); and the Centre for Global Vaccine Research, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom (N.C.).

Background: Postlicensure evaluations have identified an association between rotavirus vaccination and intussusception in several high- and middle-income countries. We assessed the association between monovalent human rotavirus vaccine and intussusception in lower-income sub-Saharan African countries.

Methods: Using active surveillance, we enrolled patients from seven countries (Ethiopia, Ghana, Kenya, Malawi, Tanzania, Zambia, and Zimbabwe) who had intussusception that met international (Brighton Collaboration level 1) criteria. Read More

Sci Rep 2018 Apr 17;8(1):6064. Epub 2018 Apr 17.

Center of Evidence-based Medicine, Second Hospital of Shandong University, Jinan, China.

The Chinese government has issued the policy of promulgating the clinical use of antibacterial drugs since 2011. Prophylactic antibiotic use is a challenging problem among young children with intussusception after successful air enema reduction. There were limited data regarding the clinical value of prophylactic antibiotics for intussusception with low-risk infections. Read More

Paediatr Int Child Health 2018 Apr 6:1-5. Epub 2018 Apr 6.

a Departments of Pediatrics , Kawaguchi Municipal Medical Center , Saitama , Japan.

About 50-75% of patients with Henoch-Schönlein purpura (HSP) develop gastro-intestinal symptoms with surgical complications such as intussusception occurring in 0.7-13.6%. Read More

N Engl J Med 2018 02;378(8):719-730

From the RV3 Rotavirus Vaccine Program, Murdoch Children's Research Institute (J.E.B., A.H., E.W., D.C., J.S., F.J., G.B., K.J.L., G.L.B., K.B., N.B.-S., D.P., R.F.B., C.D.K., J.P.B.), the Department of Paediatrics, University of Melbourne (J.E.B., D.C., K.J.L., G.L.B., R.F.B., C.D.K., J.P.B.), and the Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital Melbourne (J.E.B., J.S.), Parkville, the Departments of Paediatrics and of Epidemiology and Preventive Medicine, Monash University, and the Department of Infection and Immunity, Monash Children's Hospital, Clayton (J.P.B.), and Medicines Development for Global Health (A.H.) and Global BioSolutions (J.A.), Melbourne - all in Victoria, Australia; the Department of Pharmacology and Therapy (J.A.T.), the Pediatric Research Office, Department of Paediatrics (C.D.S., A.V.I., Y.S.), and the Department of Microbiology (H.N.), Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, and PT Bio Farma, Bandung (N.S.B.) - all in Indonesia; and the Bill and Melinda Gates Foundation, Seattle (C.D.K.).

Background: A strategy of administering a neonatal rotavirus vaccine at birth to target early prevention of rotavirus gastroenteritis may address some of the barriers to global implementation of a rotavirus vaccine.

Methods: We conducted a randomized, double-blind, placebo-controlled trial in Indonesia to evaluate the efficacy of an oral human neonatal rotavirus vaccine (RV3-BB) in preventing rotavirus gastroenteritis. Healthy newborns received three doses of RV3-BB, administered according to a neonatal schedule (0 to 5 days, 8 weeks, and 14 weeks of age) or an infant schedule (8 weeks, 14 weeks, and 18 weeks of age), or placebo. Read More

Am J Surg Pathol 2018 04;42(4):529-533

Departments of Pathology.

Immunoglobulin A (IgA) vasculitis or Henoch-Schönlein purpura (HSP) typically occurs in the pediatric population, although rare cases also occur in adults. Gastrointestinal (GI) involvement is common. The "classic" histologic finding in IgA vasculitis (HSP) is leukocytoclastic vasculitis (LCV); other histologic features in biopsies of IgA vasculitis (HSP) have only been rarely described. Read More

Gastroenterology 2018 Feb 18;154(3):e4-e7. Epub 2018 Jan 18.

Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Pediatr Emerg Care 2019 Feb;35(2):121-124

Division of Pediatric Emergency Medicine, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Background: Intussusception is the most common cause of intestinal obstruction in young children, and delayed diagnosis may lead to bowel perforation. The objective of this study was to determine the prevalence of fever in patients with ileocolic intussusception and to determine its utility as a predictive symptom.

Methods: This was a 3-year retrospective study, at a tertiary care center, of children aged 1 month to 6 years, presenting with possible intussusception. Read More

Indian J Crit Care Med 2017 Nov;21(11):789-792

Department of Pediatrics, CSI Kalyani Hospital, Chennai, Tamil Nadu, India.

Meckel's diverticulum is a remnant of the proximal part of the vitellointestinal duct and is the most common congenital anomaly of the gastrointestinal tract. It may either remain asymptomatic or present with myriad of clinical presentations. Gastrointestinal bleeding is the most common presentation in children whereas it is intestinal obstruction in the case of adults. Read More

Hum Vaccin Immunother 2018 04 18;14(4):1027-1034. Epub 2018 Jan 18.

a Julius Center for Health Sciences, University Medical Center Utrecht , Utrecht , The Netherlands.

The Fifth European Expert Meeting on Rotavirus Vaccination was convened in Utrecht, The Netherlands, in March 2017. The 2-day meeting included invited lectures as well as original oral and poster presentations and brought together experts from 21 countries. Summary findings of the meeting include: Rotavirus vaccination programmes in Europe have resulted in reductions of 60-90% in rotavirus outpatient visits and hospitalizations. Read More

Vaccine 2018 Dec 21;36(51):7836-7840. Epub 2017 Nov 21.

Janak Medical and Research Center, Balaju, Kathmandu, Nepal; B & B Hospital, Gwarko, Lalitpur, Nepal.

Background: Rotavirus is the most common cause of severe diarrhea in Nepali children, accounting for 25-33% of childhood diarrhea hospitalizations. Two rotavirus vaccines recommended for inclusion in national immunization programs have been associated with a low risk of intussusception in post-marketing studies conducted in several countries. Data on the epidemiology of intussusception hospitalizations are lacking in Nepal. Read More

Can Fam Physician 2017 11;63(11):863-865

Associate Professor in the Department of Paediatrics at the University of Toronto and a staff physician in the Division of Paediatric Emergency Medicine at the Hospital for Sick Children.

Clin Endosc 2017 Nov 18;50(6):605-608. Epub 2017 Oct 18.

Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Heterotopic gastric mucosa (HGM) is a rare anomaly in the small bowel and may be the cause of intussusception when it gets a lead point in the jejunum. All cases of intussusception due to intestinal HGM have been treated with surgical resection. A 5-year-old girl presented with chief complaints of vomiting and abdominal pain for 2 weeks. Read More

Children (Basel) 2017 Oct 19;4(10). Epub 2017 Oct 19.

Department of Pediatrics, Okmeydani Education & Training Hospital, Istanbul 34384, Turkey.

Although intussusception and food allergy are common health problems in childhood, the relation between these two diseases remain obscure. The aim of this study is to investigate the relationship between food allergy and intussusception, and the factors associated with both. Patients diagnosed with intussusception by the Brighton Collaboration Intussusception Working Group criteria were prospectively investigated for food allergy per the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Guideline. Read More

J Emerg Med 2017 Dec 21;53(6):815-818. Epub 2017 Oct 21.

Rady Children's Hospital, University of California, San Diego, California.

Background: Currently, no laboratory test can identify children with intussusception. Lactic acid is a marker of ischemia in gastrointestinal emergencies.

Objectives: We present a case series comparing lactic acid levels in children with suspected and confirmed intussusception. Read More

J Pediatr Surg 2017 Dec 5;52(12):2093-2096. Epub 2017 Sep 5.

Department of Surgery, Florida International University, Sacred Heart Medical Group, Pensacola, FL. Electronic address:

Legend holds that treating the hundreds of children injured in the Halifax explosion of December 6, 1917, compelled Dr. William E. Ladd (1880-1967) to dedicate his career to the surgical care of infants and children. Read More

J Korean Med Sci 2017 Oct;32(10):1647-1656

Department of Pediatrics, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.

We investigated the adenoviral etiology and seasonal epidemic trends in intussusception and each adenoviral subgroup. Also we confirmed whether we can use the adenovirus data of Acute Infectious Agents Laboratory Surveillance Report (AIALSR) as an epidemic predictor of intussusception. Patients with intussusception (n = 126), < 5 years old, were enrolled and matched by age and sex with controls suffering acute gastroenteritis without intussusception (n = 106), all recruited at 8 centers. Read More

Gastroenterology 2017 Sep 3;153(3):e10-e11. Epub 2017 Aug 3.

Department of Pediatrics, Pediatric Nephrology, Ghent University Hospital, De Pintelaan, Belgium.

Arch Dis Child 2017 Dec 29;102(12):1117. Epub 2017 Jul 29.

Department of Paediatrics, Hywel Dda University Health Board, Glangwili General Hospital, Carmarthen, UK.

Vaccine 2018 Dec 11;36(51):7775-7779. Epub 2017 Jul 11.

Department of Paediatrics & Child Health, Aga Khan University, Karachi, Pakistan. Electronic address:

Background: Rotavirus vaccination introduction in routine immunization is under consideration in Pakistan. Data on the baseline epidemiology of intussusception will inform surveillance strategies for intussusception after rotavirus vaccine introduction in Pakistan. We describe the epidemiology of intussusception-associated hospitalizations among children <2years of age in Karachi, Pakistan. Read More

Indian J Pediatr 2018 Jan 16;85(1):53-59. Epub 2017 Jun 16.

Department of Pediatrics, Advanced Pediatric Centre (APC), Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.

Pertussis and rotavirus vaccines have been the subject of several controversies over the years. In this paper the authors discuss facts and myths behind these controversies and also suggest solutions to overcome some limitations of these vaccines. The whole-cell pertussis vaccine (wPV) came into disrepute due to the associated adverse reactions, resulting in its replacement by acellular pertussis vaccine (aPV) in industrialized nations in 1990s. Read More

Heliyon 2017 May 16;3(5):e00302. Epub 2017 May 16.

Indian Institute of Technology, New Delhi, India.

A phase III randomized double-blind placebo-controlled trial was conducted in the urban neighborhoods of Delhi to assess whether Oral Rotavirus Vaccine ROTAVAC interferes with the immune response to childhood vaccines when coadministered. Infants aged 6 weeks were randomized to receive three doses of either ROTAVAC or placebo along with childhood vaccines: Oral Polio Vaccine and vaccines against Diphtheria, Pertussis, Tetanus, Hepatitis B and type b given as Pentavalent at 6, 10, 14 weeks of age. Blood specimens were collected from all infants at baseline and 4 weeks post dose 3 to assess the immune response to antigens in Oral Polio Vaccine, Pentavalent and ROTAVAC vaccines. Read More

Dtsch Arztebl Int 2017 Apr;114(15):255-262

Immunization Unit, Robert Koch Institute Berlin, Robert Koch Institute Berlin; Institute of Social Paediatrics and Adolescent Medicine, Ludwig-Maximilians-Universität München.

Background: In 2013, the German Standing Committee on Vaccination (Ständige Impfkommission, STIKO) recommended rotavirus (RV) vaccination for all infants while stating that this mildly increased the risk of intussusception, a potentially life-threatening event. Since this recommendation was issued, multiple observational studies on this topic designed as self-controlled case series (SCCS) have been published. The SCCS design is particularly suitable for the study of rare adverse effects of medications. Read More

Pediatr Dev Pathol 2018 Jul-Aug;21(4):401-405. Epub 2017 Apr 18.

4 Department of Paediatric Surgery, Birmingham Children's Hospital, Birmingham, UK.

Lipoblastoma is a benign adipose tumor typically presenting in infancy in superficial soft tissues of extremities. Intestinal complications secondary to intraabdominal or retroperitoneal involvement are exceedingly rare. We describe a unique case of a primary intestinal lipoblastoma arising from the submucosa of the transverse colon in an otherwise healthy 18-month-old boy. Read More

J Med Imaging Radiat Oncol 2017 Dec 17;61(6):711-717. Epub 2017 Apr 17.

Monash Imaging, Monash Health, Clayton, Victoria, Australia.

There is variable international practice regarding the technique used for image-guided enema reduction in paediatric intussusception. A recent meta-analysis found pneumatic reduction to be more effective than hydrostatic techniques. Clinical practice variation may impact on perforation rates, ionizing radiation exposure and requirement for surgery. Read More

J Pediatr 2017 07 10;186:208-208.e1. Epub 2017 Apr 10.

Department of PediatricsNew York University School of Medicine New York, New York.

Yonsei Med J 2017 May;58(3):631-636

Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital, Seoul, Korea.

Purpose: Despite withdrawal of RotaShield® and the development of second generation live attenuated rotavirus vaccines, concerns remain regarding the relationship between rotavirus vaccine and intussusception. Nevertheless, since there is no study in Korea, we reviewed data from cases at Severance Children's Hospital to determine the association between rotavirus vaccine and intussusception.

Materials And Methods: Patients coded as intussusception and following a prescription of RotaTeq® from 2007 to 2013 were reviewed. Read More