Search Our Scientific Publications & Authors

Keio J Med 2021 Jun 8. Epub 2021 Jun 8.

Department of Pediatrics, National Hospital Organization Saitama Hospital, Saitama, Japan.

Infection with Yersinia pseudotuberculosis, a known causal pathogen of human bacterial gastroenteritis, causes various symptoms and complications. A previously healthy 7-year-old girl was admitted because of fever and gastrointestinal symptoms. She was initially diagnosed with intussusception by abdominal ultrasonography. Read More

Cancer Genet 2021 May 24;256-257:106-109. Epub 2021 May 24.

Cancer Genetics and Genomics, Stanford Health Care, United States; Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, United States.

A 35-year-old Filipino woman presented with epigastric pain and was found to have two large jejunal and ileal inflammatory fibroid polyps (IFPs) and dozens of subcentimeter small bowel submucosal nodules. Targeted exon sequencing of PDGFRA on the resected jejunum IFP identified a variant c.1664A>G that was subsequently confirmed in the germline. Read More

J Indian Assoc Pediatr Surg 2021 Mar-Apr;26(2):131-132. Epub 2021 Mar 4.

Department of Pediatric Surgery, Apollo BGS Hospital, Mysore, Karnataka, India.

We report a case of intussusception presenting as bilious vomiting in a term neonate. Intussusception should be considered as a differential diagnosis even in the neonatal period. Ultrasound scan may help in early diagnosis. Read More

Clin J Gastroenterol 2021 Jun 3. Epub 2021 Jun 3.

Department of Internal Medicine, Saint Louis University School of Medicine, 1008 South Spring Ave, Saint Louis, MO, 63110, USA.

Intussusception more commonly occurs in pediatrics but is a rare cause of bowel obstruction and gastrointestinal bleeding in adults. It typically occurs in adults due to a malignancy, which serves as a pathologic lead point. We present a case of a 64-year-old female with nausea, vomiting, and melena who was found to have intussusception associated with a primary jejunal amelanotic melanoma. Read More

Indian J Pediatr 2021 May 31. Epub 2021 May 31.

The INCLEN Trust International, F1/5, Okhla Industrial Area, Phase 1, New Delhi, 110020, India.

Objective: To report background intussusception epidemiology in children under-two years in Coimbatore district of Tamil Nadu state, India, prior to rotavirus vaccine (RVV) introduction.

Methods: Prospective sentinel surveillance was done at four hospitals in Coimbatore during April 2016 to September 2017. The children aged >1 mo and < 24 mo with diagnosed intussusception were recruited and data on clinical, treatment, diet, immunization, and sociodemography were collected. Read More

AEM Educ Train 2021 Jul 23;5(3):e10526. Epub 2020 Sep 23.

Department of Emergency Medicine and Pediatrics University of California San Francisco CA USA.

Objectives: Intussusception is a pediatric medical emergency that can be difficult to diagnose. Radiology-performed ultrasound is the diagnostic study of choice but may lead to delays due to lack of availability. Point-of-care ultrasound for intussusception (POCUS-I) studies have shown excellent accuracy and reduced lengths of stay, but there are limited POCUS-I training materials for pediatric emergency medicine (PEM) providers. Read More

Vaccine 2021 Jun 12;39(27):3633-3640. Epub 2021 May 12.

PATH, India. Electronic address:

Background And Aims: ROTAVAC® (frozen formulation stored at -20 °C) and ROTAVAC 5D® (liquid formulation stable at 2-8 °C) are rotavirus vaccines derived from the 116E human neonatal rotavirus strain, developed and licensed in India. This study evaluated and compared the safety and immunogenicity of these vaccines in an infant population in Zambia.

Methods: We conducted a phase 2b, open-label, randomized, controlled trial wherein 450 infants 6 to 8 weeks of age were randomized equally to receive three doses of ROTAVAC or ROTAVAC 5D, or two doses of ROTARIX®. Read More

Eur Radiol 2021 May 11. Epub 2021 May 11.

Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Objective: To identify predictors of failed enema reduction in children with intussusception.

Methods: PubMed and EMBASE were searched for all studies published over a 20-year time frame, prior to March 25, 2020. Original articles that reported predictors of failed enema reduction were included. Read More

Int J Clin Pract 2021 May 6:e14322. Epub 2021 May 6.

Department of Pediatrics, Faculty of Medicine, Gazi University, Ankara, Turkey.

Aims: We aimed to determine the factors that determine the conditions in cases of invagination with spontaneous reduction.

Methods: Study was conducted retrospectively in the Paediatric Emergency Department (PED) of the tertiary University Hospital in Ankara, Turkey. Invagination cases admitted between January 1, 2019 and December 31, 2019 were included in the study. Read More

Vaccine 2021 05 28;39(22):3018-3024. Epub 2021 Apr 28.

Kawasaki City Institute for Public Health, 3-25-13 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan.

The Japanese immunization program has made considerable progress since 2009: several new vaccines have been introduced and most are included in the National Immunization Program (NIP). In October 2020, the Japanese law on immunization was revised, which resulted in a few laudable achievements. First, rotavirus vaccines were added to the NIP, 10 years after their introduction, and noteworthy studies of vaccine effectiveness and the incidence of intussusception in Japanese children were published. Read More

ANZ J Surg 2021 Apr 27. Epub 2021 Apr 27.

The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China.

Background: To determine risk factors for intestinal necrosis in intussusception cases among children with failed non-surgical reduction for intussusception.

Methods: Totally, 540 hospitalized individuals with unsuccessful air-enema reduction in our hospital between November 2010 and November 2020 were assessed in this retrospective study. The 540 intussusception cases were divided into the intestinal necrosis and non-intestinal necrosis groups. Read More

J Infect Chemother 2021 Jul 15;27(7):940-948. Epub 2021 Apr 15.

Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, 060-8543, Japan.

In Japan, a monovalent rotavirus vaccine (RV1) and a pentavalent rotavirus vaccine (RV5) were launched as voluntary vaccinations in November 2011 and July 2012, respectively. Rotavirus (RV) vaccine coverage in Japan increased from 30.0% in 2012 to 78. Read More

Pediatr Gastroenterol Hepatol Nutr 2021 Mar 4;24(2):135-144. Epub 2021 Mar 4.

Department of Pediatrics, Korea University Ansan Hospital, Ansan, Korea.

Purpose: Although ultrasonography is the gold standard of diagnosing intussusception, plain abdomen radiograph (AXR) is often used to make differential diagnosis for pediatric patients with abdominal pain. In intussusception patients, we aimed to analyze the AXR and clinical data to determine the characteristics of early AXR findings associated with diagnosis of intussusception and recurrence after reduction.

Methods: Between January 2011 and June 2018, 446 patients diagnosed with intussusception based on International Classification of Diseases-10 code of K56. Read More

Pediatr Surg Int 2021 Jul 7;37(7):887-895. Epub 2021 Apr 7.

Department of Neonatal Gastrointestinal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China.

Purpose: Childhood obesity is a worsening epidemic. Little is known about the impact of overweight and obesity (OV-OB) on clinical outcomes after reduction for intussusception in children. The aim of this study was to compare clinical outcomes after primarily air enema reduction for intussusception in grouped OV-OB (body mass index-for-age percentile ≥ 85) pediatric patients compared with no OV-OB patients. Read More

BMJ Case Rep 2021 Mar 16;14(3). Epub 2021 Mar 16.

Department of Paediatrics, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK

Dengue fever is one of the most common neglected tropical diseases with an increasing trend seen in Sri Lanka and many other tropical countries. A number of unusual presentations and complications of dengue fever have been reported, and acute abdomen is one such presentation. However, intussusception as the cause of acute abdomen in a patient with dengue haemorrhagic fever has not been previously reported. Read More

J Clin Ultrasound 2021 Jul 6;49(6):602-604. Epub 2021 Mar 6.

Department of Pediatric Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, P.R. China.

Although gastrointestinal polyps are a common disease, appendiceal orifice polyps are rare and usually found incidentally during autopsy or surgery. Data on the sonographic features of appendiceal orifice polyps in children are limited. We describe the sonographic features of appendiceal orifice polyps in two children. Read More

Front Pediatr 2021 4;9:601492. Epub 2021 Feb 4.

Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Intussusception, the most common abdominal emergency in early childhood, is frequently misdiagnosed at initial presentation. The effect of using point-of-care ultrasonography (POCUS) by emergency medicine physicians on pediatric intussusception misdiagnosis rate remains unclear. Here, we summarize outcomes and misdiagnoses before and after training junior and senior physicians on using POCUS for diagnosing intussusception and compared their performance levels. Read More

Trop Doct 2021 Feb 11:49475521991348. Epub 2021 Feb 11.

Director Professor, Genetic division, Department of Pediatrics, Maulana Azad Medical College, Lok Nayak Hospital, New Delhi, India.

Atypical coeliac disease in young children is frequently missed when it presents atypically as non-gastrointestinal presentations to different specialties. There was a greater delay (54 months) in establishing the diagnosis in those with atypical coeliac disease (p < 0.001). Read More

Front Immunol 2020 21;11:580219. Epub 2021 Jan 21.

Genetics, Vaccines and Pediatric Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS) and Universidad de Santiago de Compostela (USC), Santiago de Compostela, Spain.

Background: Rotavirus (RV) is an enteric pathogen that has devastating impact on childhood morbidity and mortality worldwide. The immunologic mechanism underlying the protection achieved after RV vaccination is not yet fully understood.

Methods: We compared the transcriptome of children affected by community-acquired RV infection and children immunized with a live attenuated RV vaccine (RotaTeq). Read More

Indian J Pediatr 2021 03 5;88(Suppl 1):112-117. Epub 2021 Feb 5.

Department of Pediatrics, Kalinga Institute of Medical Sciences (KIMS), Deemed to be Unversity, Bhubaneswar, Odisha, 751024, India.

Objective: To study the epidemiology of intussusception in children < 2 y of age, postintroduction of Rotavac® (an indigenous oral rotavirus vaccine).

Methods: A multicenter hospital-based surveillance was conducted in Odisha from February 2016 to June 2019. The cases were diagnosed according to Brighton level-1 criteria. Read More

J Emerg Med 2021 May 19;60(5):626-632. Epub 2021 Jan 19.

Department of Emergency Medicine, Mount Sinai Morningside, New York, New York.

Background: Intussusception (INT) is a common cause of bowel obstruction in young children. Delay in diagnosis can lead to significant morbidity and mortality. There have been several studies evaluating early point-of-care ultrasound (POCUS) in the diagnosis of INT by nonradiologists. Read More

Indian J Pediatr 2021 03 16;88(Suppl 1):118-123. Epub 2021 Jan 16.

The Wellcome Trust Research Laboratory, Christian Medical College, Vellore, Tamil Nadu, India.

Objective: To describe epidemiology of intussusception post-introduction of the rotavirus vaccine.

Methods: Hospital-based active surveillance system was set up in three tertiary care hospitals in Chandigarh and Haryana, India, to enroll children <2 y of age admitted with intussusception as per Brighton Collaboration Level-I criteria. The clinical characteristics, treatment modalities, seasonal trends, and outcome of the illness episodes were described. Read More

Indian J Pediatr 2021 03 6;88(Suppl 1):131-137. Epub 2021 Jan 6.

Christian Medical College, Vellore, Tamil Nadu, India.

Objective: To determine the clinical and epidemiological profile of Intussusception in children aged <2 y after introduction of rotavirus vaccine in Universal Immunization Programme of Rajasthan.

Method: This was a hospital-based multi-centric surveillance study conducted at three tertiary care sentinel sites in Rajasthan over a period of 2 y. Children <2 y of age admitted with intussusception as per Brighton's criteria 1 were enrolled. Read More

J Med Ultrason (2001) 2021 Jan 2;48(1):21-29. Epub 2021 Jan 2.

Department of Radiology, Saitama Children's Medical Center, 1-2 Shintoshin, Chuo-ku, Saitama, Saitama, 330-8777, Japan.

Choledochal cyst, which is a congenital dilatation of the bile duct, is a common congenital disease requiring surgical repair. This disease usually occurs in children aged < 10 years, necessitating a relatively long follow-up after repair. The incidence of this congenital disease in Asian countries, including Japan, was reported to be higher than that in other countries. Read More

Health Serv Res 2021 Apr 29;56(2):225-234. Epub 2020 Dec 29.

Division of General Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA.

Objective: To create definitions for complications for 16 serious pediatric conditions using the International Classification of Diseases, 10th Revision, Clinical Modification or Procedure Coding System (ICD-10-CM/PCS), and to assess whether complication rates are similar to those measured with ICD-9-CM/PCS.

Data Sources: The Healthcare Cost and Utilization Project State Emergency Department and Inpatient Databases from five states between 2014 and 2017 were used to identify cases and assess complication rates. Incidences were calculated using population counts from the 5-year American Community Survey. Read More

Postgrad Med J 2020 Dec 11. Epub 2020 Dec 11.

Radiology, Dokkyo Medical University, Shimotsuga-gun, Tochigi, Japan.

J Minim Invasive Gynecol 2021 May 11;28(5):933-935. Epub 2020 Dec 11.

Division of Gynecology, Department of Pediatrics, Obstetrics and Gynecology (Drs. Dubuisson, Benmohamed, and Petignat).

BMJ Case Rep 2020 Dec 9;13(12). Epub 2020 Dec 9.

Department of Pediatrics, Bharati Vidyapeeth Deemed University Medical College, Pune, Maharashtra, India.

Intussusception in children is mainly idiopathic or due to a viral aetiology. Occasionally, pathological lead points like Meckel diverticulum or rarely metabolic causes like hyperglycaemia can result in formation of an intussusception. We describe the case of a boy with diabetic ketoacidosis presenting with abdominal pain. Read More

Pak J Med Sci 2020 Nov-Dec;36(7):1640-1644

Ping Wang, Department of Pediatrics, Hebei Children's Hospital, Shijiazhuang, 050031, Hebei, P.R. China.

Objective: To explore the effect of manipulative reduction combined with air enema on intestinal mucosal immune function in children with intussusception.

Methods: This is a prospective randomized controlled study in which 60 children with primary intussusception admitted to Hebei Children's Hospital from October 2018 to October 2019 were selected for this study. They were randomly divided into two groups. Read More

Vaccine 2021 01 18;39(1):45-58. Epub 2020 Nov 18.

Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong. Electronic address:

Background: Rotavirus is a common cause of severe gastroenteritis in young children in Hong Kong (HK) with a high economic burden. This study aimed to evaluate the cost-effectiveness of introducing rotavirus vaccination into the HK Government's Childhood Immunisation Programme (CIP) and to include the potential protective effect of the vaccine against seizures.

Methods: A decision-support model was customised to estimate the potential impact, cost-effectiveness and benefit-risk of rotavirus vaccination in children below 5 years over the period 2020-2029 in HK. Read More