Search Our Scientific Publications & Authors

Cureus 2022 May 25;14(5):e25315. Epub 2022 May 25.

Paediatric Surgery, San Fernando Teaching Hospital, San Fernando, TTO.

Retrograde intussusception (RINT) and giant Meckel's diverticulum (MD) are both rare pathologies and are seldom encountered in surgical practice. Thus, it is exceptional for both conditions to be seen in the same patient, with very few published case reports in the paediatric population. This case describes a three-month-old male who was referred to our paediatric surgery unit following a diagnosis of intussusception on an ultrasound scan. Read More

Am J Emerg Med 2022 Jun 15;58:255-264. Epub 2022 Jun 15.

Department of Emergency Medicine, Rush University Medical Center, Chicago, IL, United States of America.

Objectives: Ileocolic intussusception can be challenging to diagnose due to vague complaints, but rapid diagnosis and treatment can help prevent morbidity and mortality. Prior research has focused on radiologic ultrasound, with more recent studies focusing on point-of-care ultrasonography (POCUS). This systematic review and meta-analysis assesses the diagnostic accuracy of POCUS for children with suspected ileocolic intussusception. Read More

Indian J Pediatr 2022 Jun 21. Epub 2022 Jun 21.

Department of Pediatric Surgery, Calcutta Medical Research Institute, Kolkata, West Bengal, India.

J Pediatric Infect Dis Soc 2022 Jun 17. Epub 2022 Jun 17.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Pentavalent rotavirus vaccine has been associated with a small increase in intussusception, but pre- and post-introduction data are lacking in many low-resource settings. Using chart review and prospective surveillance data, intussusception incidence was estimated in Bamako, Mali. The mean annual intussusception incidence post-introduction was not significantly different from that of pre-introduction. Read More

Eur J Pediatr Surg 2022 Jun 10. Epub 2022 Jun 10.

Department of Pediatric Surgery, Hangzhou Children's Hospital, Xiacheng District, Hangzhou, China.

We conducted a systematic review and meta-analysis to compare the efficacy and safety between laparoscopic reduction (LR) and open reduction (OR) of intussusception in infants and children. Literature searches were conducted to identify studies having compared LR and OR for children with intussusception failed to enema reduction. Parameters such as operative time, time to oral intake, length of hospital stay, overall postoperative complications, and recurrence were pooled and compared by meta-analysis. Read More

Case Rep Pediatr 2022 24;2022:8245139. Epub 2022 May 24.

Department of Pediatrics, Mohammed VI University Hospital, Oujda, Morocco.

Bean syndrome (BS) or blue rubber bleb nevus syndrome is a rare clinical entity characterized by venous malformations mainly in the skin and digestive tract, whose hemorrhagic complications can be life threatening. We report a case of Bean syndrome in a 3-year-old child of nonconsanguineous parents, in whom the diagnosis of miliary hemangiomatosis was initially made in view of a huge mass on the left thigh, taking the knee, and then the progressive appearance of a skin disorder with bluish swellings of variable sizes spread over the whole body. The patient was put on beta-blockers but without improvement. Read More

Lancet Infect Dis 2022 May 16. Epub 2022 May 16.

Division of Epidemiology, Indian Council of Medical Research-National Institute of Cholera and Enteric Diseases, Kolkata, India; Division of Bacteriology, Indian Council of Medical Research-National Institute of Cholera and Enteric Diseases, Kolkata, India. Electronic address:

Background: Rotavirus is the leading cause of severe dehydrating gastroenteritis among children younger than 5 years in low-income and middle-income countries. Two vaccines-Rotavac and Rotasiil-are used in routine immunisation in India. The safety and immunogenicity of these vaccines administered in a mixed regimen is not documented. Read More

Pan Afr Med J 2022 22;41:157. Epub 2022 Feb 22.

WHO Regional Office for Africa (WHO/AFRO), Brazzaville, Republic of Congo.

Surveillance for intussusception (IS) post-rotavirus vaccine introduction in World Health Organization Africa Region (WHO/AFRO) has been restricted mainly to the large referral teaching hospitals. The choice of these facilities for surveillance was made to utilize the abundant expertise of specialists in paediatrics and surgery in these hospitals who can diagnose and manage such patients with IS. The surveillance has been well coordinated by the African Intussusception Surveillance Network established in 2012. Read More

Pediatr Infect Dis J 2022 06 6;41(6):507-513. Epub 2022 May 6.

From the National Centre for Immunisation Research and Surveillance, Westmead, New South Wales.

Background: Multiple studies have shown an association between intussusception (IS) and receipt of monovalent or pentavalent rotavirus vaccine (RV) in the previous 21 days. Disease severity is an important consideration for risk-benefit evaluations of RV, but no studies have compared the severity of IS within 21 days of vaccination (vaccine-associated, VA) and later (not temporally-associated, VNA).

Methods: We used active hospital-based surveillance in the Australian Paediatric Active Enhanced Disease Surveillance (PAEDS) network (July 2007 to February 2018) to identify infants ≤9 months of age meeting Brighton level 1 criteria for IS. Read More

Best Pract Res Clin Gastroenterol 2022 Feb-Mar;56-57:101788. Epub 2022 Feb 24.

Univ. Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000, Lille, France; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Jeanne de Flandre Children's Hospital, CHU Lille, F-59000, Lille, France. Electronic address:

Cystic fibrosis (CF) is the most frequent life-limiting autosomal recessive disease in Caucasians, affecting the respiratory tract, but also the pancreas, gut, and hepatobiliary tract. CF is caused by variants in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. Prognosis of CF has markedly improved over the last 20 years because of the management in CF centers and recent introduction of CFTR modulators, aimed at correcting the defective CFTR protein. Read More

Pediatrics 2022 06;149(6)

Department of Pediatric General Surgery, Regina Margherita Children's Hospital, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy.

Nonrespiratory conditions related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have been largely described. Ileocolic intussusception has been reported in association with SARS-CoV-2 infection in 10 children, raising the possibility of an etiopathologic role for the virus, but none of these cases documented tissue pathology that would have supported SARS-CoV-2 intestinal inflammation. We report 2 cases of intussusception in patients with SARS-CoV-2 infection who were treated at different pediatric tertiary centers in Europe and provide evidence of the presence of the virus in mesenteric and intestinal tissues of the patients. Read More

Am Surg 2022 Mar 18:31348211060431. Epub 2022 Mar 18.

25063Metropolitan Hospital, New York, NY, USA.

Meckel's diverticulum is commonly symptomatic the first 2 years of life. Complications associated with Meckel's diverticulum are due to gastrointestinal (GI) bleeding or obstruction. A 5-day-old male presented to the emergency department (ED) with an episode of bright red blood per rectum (BRBPR) associated with emesis. Read More

J Korean Med Sci 2022 Feb 28;37(8):e60. Epub 2022 Feb 28.

Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Intussusception refers to the invagination of a part of the intestine into itself. The exact cause for this condition is unknown in most cases. The active implementation of coronavirus disease 2019 (COVID-19) infection control guidelines has reduced the spread of COVID-19 and the incidence of other infectious diseases in children. Read More

J Infect Dis 2022 Feb 4. Epub 2022 Feb 4.

Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Australia.

Background: Rotarix (GlaxoSmithKline) oral rotavirus vaccine is licensed as two doses in the first six months of life. In high child-mortality settings, clinical protection conferred by two doses of Rotarix is reduced. We assessed vaccine immune response when an additional dose of Rotarix was given to Australian Aboriginal children 6 to < 12 months old. Read More

J Pediatr 2022 05 31;244:115-119.e1. Epub 2022 Jan 31.

Division of Hepatology, Gastroenterology, and Nutrition and the Reference Center for Congenital and Malformative Esophageal Disorders, Department of Pediatrics, University of Lille, CHU Lille, Lille, France; Inserm, U1286, Institute for Translational Research in Inflammation, University of Lille, CHU Lille, Lille, France.

Objective: To evaluate the feasibility of endoscopic gastrojejunal tube (GJT) placement in infants and children.

Study Design: All children undergoing endoscopic GJT placement between January 2010 and December 2019 were included in this single-center retrospective study. Difficulties with and failure of GJT placement, complication rates, and device longevity, efficacy, and duration were assessed. Read More

Pediatr Gastroenterol Hepatol Nutr 2022 Jan 7;25(1):21-29. Epub 2022 Jan 7.

Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: The objective of this study was to identify the significance of 24-hour post-reduction ultrasonography (US) in pediatric patients with intussusception.

Methods: A total of 229 patients with intussusception who were treated with saline reduction at Severance Children's Hospital between January 2014 and September 2020 were retrospectively reviewed. The 229 patients with successful saline reduction were divided into two groups: a recurrence at 24 hours group (R, n=41) and a non-recurrence group (NR, n=188). Read More

Children (Basel) 2022 Jan 5;9(1). Epub 2022 Jan 5.

Department of Pediatrics, E-Da Hospital, Kaohsiung City 824005, Taiwan.

The common clinical manifestations of Meckel's diverticulum include painless lower gastrointestinal bleeding and intestinal obstruction due to intussusception. Intussusception induced by inverted Meckel's diverticulum has rarely been reported; furthermore, there is no report thus far of chronic nocturnal abdominal pain as a presenting symptom in children with Meckel's diverticulum. A 4-year-and-10-month-old girl with no significant history of previous illness presented with the sole complaint of chronic nocturnal abdominal pain for 3 months. Read More

J Korean Med Sci 2022 Jan 10;37(2):e16. Epub 2022 Jan 10.

Korea University College of Medicine, Seoul, Korea.

Following nonpharmaceutical intervention (NPI) to mitigate coronavirus disease 2019 has led to drastic reduction in incidence of communicable disease. Intussusception is commonly preceded by infectious pathogens. Indirect effect from NPI implementation on incidence of intussusception has not been understood fully. Read More

J Eur Acad Dermatol Venereol 2022 Apr 22;36(4):615-622. Epub 2022 Jan 22.

Department of Dermatology, Taichung Veterans General Hospital, Taichung, Taiwan.

Background: Microbial dysbiosis has been implicated in the development of atopic dermatitis (AD). The risk of development of AD following early-life infections remains unclear.

Objective: To investigate the impact of early-life infections on AD development. Read More

Transl Pediatr 2021 Nov;10(11):2888-2896

Department of Pediatrics, Chung-Ang University Hospital, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.

Background: The occurrences of infection-related systematic diseases, such as Henoch-Schönlein Purpura (HSP), intussusception, and mucocutaneous lymph node syndrome (MCLS) may have decreased, similarly to the decreased occurrence of infectious diseases following the Coronavirus disease 2019 (COVID-19) pandemic. We aimed to investigate whether there was a change in the occurrence of these diseases in South Korea after the spread of the COVID-19 pandemic.

Methods: In this multicenter, retrospective study conducted in 16 medical centers in South Korea patients diagnosed with HSP, intussusception, and MCLS at the age of <18 years between January 2016 and December 2020 were included. Read More

Birth Defects Res 2022 02 29;114(3-4):136-144. Epub 2021 Dec 29.

Gastrointestinal and Neonatal Surgery Department, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation base of Child development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.

Purpose: To investigate the factors that influence the occurrence of anorectal malformations (ARMs).

Methods: From December 2018 to December 2019, 136 children treated for ARMs at the Children's Hospital of Chongqing Medical University were included in the case group. The control group consisted of children with intussusception or perianal abscesses. Read More

BMC Pediatr 2021 12 24;21(1):587. Epub 2021 Dec 24.

Pediatric Surgery Department, Alexandria Faculty of Medicine, Alexandria, 21615, Egypt.

Background: While necrotizing enterocolitis (NEC) is a prevalent condition in preterm neonates admitted to neonatal intensive care unit (NICU), intussusception is exceedingly uncommon and often overlooked. This is due to the fact that they share many clinical characteristics. The initial misdiagnosis of intussusception in preterm neonates (IPN) especially has led to a delay in their management, which increases the risk of developing compromised bowel. Read More

JAMA Netw Open 2021 12 1;4(12):e2139974. Epub 2021 Dec 1.

Ospedale Bambino Gesù IRCCS, Rome, Italy.

Importance: Severe gastrointestinal (GI) manifestations have been sporadically reported in children with COVID-19; however, their frequency and clinical outcome are unknown.

Objective: To describe the clinical, radiological, and histopathologic characteristics of children with COVID-19 presenting with severe GI manifestations to identify factors associated with a severe outcome.

Design, Setting, And Participants: A multicenter retrospective cohort study (February 25, 2020, to January 20, 2021) enrolled inpatient and outpatient children (aged <18 years) with acute SARS-CoV-2 infection, confirmed by positive real-time reverse-transcriptase-polymerase chain reaction on nasopharyngeal swab or fulfilling the US Centers for Disease Control and Prevention criteria for multisystem inflammatory syndrome in children (MIS-C). Read More

BMC Pediatr 2021 12 16;21(1):577. Epub 2021 Dec 16.

Department of Pediatric General Surgery, Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Background: The most critical concern for the management of childhood intussusception is bowel resection due to intestinal ischemia and necrosis. The early prediction of this problem is of great importance. We investigated the value of various combinations of inflammatory factors to predict intestinal necrosis and resection. Read More

J Paediatr Child Health 2021 Dec 16. Epub 2021 Dec 16.

Department of Neurology, Sydney Children's Hospital, Sydney, New South Wales, Australia.

Children (Basel) 2021 Nov 21;8(11). Epub 2021 Nov 21.

Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

Coronavirus disease 2019 (COVID-19) changed the epidemiology of various diseases. The present study retrospectively investigates the epidemiologic and clinical changes in pediatric intussusception for ages ≤ 7 years before (February 2019-January 2020) and after (February 2020-January 2021) the COVID-19 outbreak in a single pediatric emergency department of a university-affiliated tertiary hospital. The incidence of communicable diseases-defined as infectious diseases with the potential for human-to-human transmission via all methods, non-communicable diseases, and intussusception were decreased following the COVID-19 outbreak (15,932 to 3880 (24. Read More

J Pediatr Surg 2022 Jan 5;57(1):147-152. Epub 2021 Oct 5.

Center for Surgical Trials and Evidence-Based Practice (C-STEP), McGovern Medical School, University of Texas Health Science Center, 6431 Fannin Street, MSB 5.256, Houston, TX 77030, United States; Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center, 6431 Fannin Street, MSB 5.246, Houston, TX 77030, United States; Children's Memorial Hermann Hospital, 6411 Fannin Street, Houston, TX 77030, United States. Electronic address:

Background/purpose: We implemented a quality improvement (QI) initiative to safely reduce post-reduction monitoring for pediatric patients with ileocolic intussusception. We hypothesized that there would be decreased length of stay (LOS) and hospital costs, with no change in intussusception recurrence rates.

Methods: A retrospective cohort study was conducted of pediatric ileocolic intussusception patients who underwent successful enema reduction at a tertiary-care pediatric hospital from January 2015 through June 2020. Read More

Ann Med Surg (Lond) 2021 Oct 6;70:102915. Epub 2021 Oct 6.

Intensive Care Unit, Mohammed VI University Hospital Center, Oujda, Morocco.

Introduction: Like other halogenated agents, sevoflurane can potentially cause a toxic reaction including severe hepatic failure which can lead to the death of the patient. However, Halogen immuno-allergic hepatitis is a very rare complication of anesthesia. We reported a 10 months' child who presented a severe hepatic injury after sevoflurane exposure. Read More

World J Surg 2022 02 20;46(2):310-321. Epub 2021 Oct 20.

Austin Precinct, Department of Surgery, University of Melbourne, Melbourne, VIC, Australia.

Introduction: Intussusception is one of the commonest causes of bowel obstruction in infants. Most infants in Low- and Middle-Income Countries (LMICs) undergo an invasive operative intervention. Supported by simulation-based education (SBE), the Air Enema (AE) non-operative technique was introduced in 2016 in Myanmar. Read More

Am J Emerg Med 2022 Apr 9;54:325.e1-325.e2. Epub 2021 Oct 9.

Division of Pediatric Emergency Medicine, University of Minnesota Medical School, Minneapolis, MN, United States of America.

The differential diagnosis for bilious emesis and hematochezia in newborns is broad and includes structural abnormalities (malrotation with volvulus, atresia, pyloric stenosis, intussusception), infectious colitis, necrotizing enterocolitis, milk protein intolerance, vascular malformations, and other bleeding disorders. Here we report a case of bilious emesis and hematochezia in an 8-day-old male infant who was ultimately found to have goat's milk protein intolerance after an extensive workup ruling out other pathology. There have been limited studies that examine goat's milk protein intolerance in pediatric patients, and to our knowledge, our paper presents the youngest patient presenting with bilious emesis related to goat's milk intake. Read More