3,201 results match your criteria Pediatrics Hypoglycemia


The GLOW study does not light up the true PES recommendations for management of hypoglycemia in newborns.

J Pediatr 2020 Jun 27. Epub 2020 Jun 27.

Emeritus Professor and Chair, Dept of Pediatrics, University of Pittsburgh Professorial Lecturer, Pediatric Endocrinology and Diabetes Icahn School of Medicine at Mt Sinai, NY.

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http://dx.doi.org/10.1016/j.jpeds.2020.06.070DOI Listing

A Korean child diagnosed with malonic aciduria harboring a novel start codon mutation following presentation with dilated cardiomyopathy.

Mol Genet Genomic Med 2020 Jun 30:e1379. Epub 2020 Jun 30.

Department of Laboratory Medicine, Kyung Hee University School of Medicine, Seoul, Korea.

Background: Malonic aciduria (MA, OMIM#248360) is an extremely rare inherited metabolic disorder caused by the deficiency of malonyl-CoA decarboxylase. The phenotype exhibited by patients with MA is variable, but may include symptoms, such as developmental delay in early childhood, seizures, vomiting, metabolic acidosis, hypoglycemia, ketosis, and cardiomyopathy. We describe the first case of a Korean child with MA who presented with dilated cardiomyopathy (DCMP) at the age of 3 months. Read More

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http://dx.doi.org/10.1002/mgg3.1379DOI Listing

Longitudinal Auxological recovery in a cohort of children with Hyperinsulinaemic Hypoglycaemia.

Orphanet J Rare Dis 2020 Jun 24;15(1):162. Epub 2020 Jun 24.

Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Oxford Road, Manchester, M13 9WL, UK.

Background: Hypoglycaemia due to hyperinsulinism (HI) is the commonest cause of severe, recurrent hypoglycaemia in childhood. Cohort outcomes of HI remain to be described and whilst previous follow up studies have focused on neurodevelopmental outcomes, there is no information available on feeding and auxology.

Aim: We aimed to describe HI outcomes for auxology, medications, feeding and neurodevelopmental in a cohort up to age 5 years. Read More

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http://dx.doi.org/10.1186/s13023-020-01438-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313198PMC

Exenatide ER in patients with Type 1 diabetes with and without residual insulin production.

Diabetes Obes Metab 2020 Jun 23. Epub 2020 Jun 23.

Department of Medicine (Endocrinology), SUNY Upstate Medical University, Syracuse, New York, United States.

Background: Glucagon-like peptide-1 receptor agonists (GLP1RA) have activity that may benefit patients with Type 1 diabetes (T1D). Studies of GLP1RAs in T1D had mixed outcomes possibly because their effects in patients with residual insulin production were not been specifically addressed.

Methods: We performed a randomized placebo controlled trial of exenatide ER in participants with T1D with and without detectable levels of C-peptide. Read More

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http://dx.doi.org/10.1111/dom.14121DOI Listing

Management of adult patients with type 1 diabetes mellitus in Africa: A post-hoc cohort analysis of 12 African countries participating in the International Diabetes Management Practices Study (Wave 7).

Medicine (Baltimore) 2020 Jun;99(25):e20553

Clinical Pharmacology & Toxicology, University Hospital / Inselspital Bern, Bern, Switzerland.

There is a paucity of information on real world management of African adult patients with type 1 diabetes mellitus (T1DM). We aimed to describe a cohort of African adults with T1DM.The International Diabetes Management Practices Study is an observational survey conducted from 2005 to 2017. Read More

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http://dx.doi.org/10.1097/MD.0000000000020553DOI Listing

Characterization of a mouse model of islet transplantation using MIN-6 cells.

Islets 2020 Jun 22:1-16. Epub 2020 Jun 22.

Department of Pediatrics, Georgetown University , Washington, DC, USA.

Immortalized beta cells are an abundant source of insulin-producing cells. Although MIN-6 cells have similar characteristics as normal islets , the use of MIN-6 cells has not been fully described. This study characterizes mouse models of MIN-6 transplantation and rejection. Read More

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http://dx.doi.org/10.1080/19382014.2020.1763719DOI Listing

Recreational diving in persons with type 1 and type 2 diabetes: Advancing capabilities and recommendations.

Diving Hyperb Med 2020 Jun;50(2):135-143

Department of Kinesiology, Université Laval, Quebec, Canada.

Diving by persons with diabetes has long been conducted, with formal guidelines published in the early 1990s. Subsequent consensus guidelines produced following a 2005 workshop helped to advance the recognition of relevant issues and promote discussion. The guidelines were intended as an interim step in guidance, with the expectation that revisions should follow the gathering of additional data and experience. Read More

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http://dx.doi.org/10.28920/dhm50.2.135-143DOI Listing

Feasibility of neonatal haemoglobin A1C as a biomarker for retinopathy of prematurity.

Biomarkers 2020 Jun 28:1-6. Epub 2020 Jun 28.

Zietchick Research Institute (ZRI), Plymouth, MI, USA.

Retinopathy of prematurity (ROP) is a potentially serious eye disorder affecting very preterm infants. Non-proliferative ROP (NP-ROP), also known as Early Stage ROP, is characterized by deficient retinal angiogenesis. Proliferative ROP (P-ROP), also known as Late Stage ROP, is characterized by pathologic angiogenesis. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1783573DOI Listing

[Study of the quality of life and adherence to treatment in patients from 2 to 16 years-old with type 1 diabetes mellitus in Andalusia, Spain].

An Pediatr (Barc) 2020 Jun 12. Epub 2020 Jun 12.

Unidad de Endocrinología Pediátrica, Hospital Materno Infantil de Málaga, Málaga, España.

Introduction: Diabetes mellitus 1 is the second most frequent chronic disease, and the most frequent endocrine-metabolic disorder in childhood. The estimated prevalence is between 1.1 and 1. Read More

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http://dx.doi.org/10.1016/j.anpedi.2020.03.016DOI Listing

Congenital hyperinsulinsim: case report and review of literature.

Pan Afr Med J 2020 24;35:53. Epub 2020 Feb 24.

Department of pediatrics, Military Teaching Hospital Mohammed V, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.

Neonatal hypoglycemia (NH) is one of the most common abnormalities encountered in the newborn. Hypoglycemia continues to be an important cause of morbidity in neonates and children. Prompt diagnosis and management of the underlying hypoglycemia disorder is critical for preventing brain damage and improving outcomes. Read More

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http://dx.doi.org/10.11604/pamj.2020.35.53.16604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250230PMC
February 2020

Comparative meta-analysis of Kabuki syndrome with and without hyperinsulinemic hypoglycemia.

Clin Endocrinol (Oxf) 2020 Jun 13. Epub 2020 Jun 13.

Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital Düsseldorf, Medical Faculty, Düsseldorf, Germany.

Background And Objective: Kabuki syndrome (KS), caused by pathogenic variants in KMT2D or KDM6A, is associated with hyperinsulinemic hypoglycemia (HH) in 0.3-4% of patients. We characterized the clinical, biochemical and molecular data of children with KS and HH compared to children with KS without HH in a multicenter meta-analysis. Read More

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http://dx.doi.org/10.1111/cen.14267DOI Listing

Kabuki syndrome with midgut malrotation and hyperinsulinemic hypoglycemia: A rare co-occurrence from Thailand.

Am J Med Genet A 2020 Jun 11. Epub 2020 Jun 11.

Division of Medical Genetics, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Kabuki syndrome (KS) is a rare heterogeneous phenotypic genetic syndrome, characterized by hypotonia, developmental delay and/or intellectual disability with typical facial features. It is challenging to diagnose KS in newborn and young infant. We report a Thai girl who presented with two rare co-occurrence phenotypes, hyperinsulinemic hypoglycemia and midgut malrotation. Read More

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http://dx.doi.org/10.1002/ajmg.a.61723DOI Listing

Continuous glucose monitoring in adults with type 1 diabetes: Real-World Data from the German/Austrian DPV Registry.

Diabetes Technol Ther 2020 Jun 10. Epub 2020 Jun 10.

University of Ulm, Institute of Epidemiology and Medical Biometry, Albert-Einstein-Allee 41, Ulm, Germany, 89081;

Background: To analyze key indicators of metabolic control in adults with type 1 diabetes (T1D) using real-time or intermittent scanning continuous glucose monitoring (rtCGM/iscCGM) during real-life care, based on the German/Austrian/Swiss Prospective Diabetes Follow-up (DPV) registry.

Methods: Cross-sectional analysis including 233 adults with T1D using CGM. We assessed CGM metrics by sex, age group (18-<30 vs. Read More

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http://dx.doi.org/10.1089/dia.2020.0019DOI Listing

Continuous Glucose Monitoring Decreases Hypoglycemia Avoidance Behaviors, but not Worry in Parents of Youth With New Onset Type 1 Diabetes.

J Diabetes Sci Technol 2020 Jun 10:1932296820929420. Epub 2020 Jun 10.

Nemours Children's Health System, Jacksonville, FL, USA.

Background: Existing research shows that hypoglycemia fear (HF) is common in parents of children with established type 1 diabetes (T1D). We examined parental HF in the T1D recent-onset period and evaluated whether continuous glucose monitoring (CGM) adoption relates to improved outcomes of parental HF.

Methods: In , a prospective study of five- to nine-year olds with recent-onset T1D, parents completed the Hypoglycemia Fear Survey-Parents (HFS-P) at baseline (T1) and 6 (T2) and 12 (T3) months post-baseline. Read More

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http://dx.doi.org/10.1177/1932296820929420DOI Listing

Fast-Acting Insulin Aspart Use with the MiniMed™ 670G System.

Diabetes Technol Ther 2020 Jun 10. Epub 2020 Jun 10.

Stanford University, 6429, Division of Endocrinology, Department of Pediatrics, Stanford, California, United States.

BACKGROUND This study assessed the efficacy and safety of ultra-rapid insulin Fiasp® in the hybrid closed-loop MiniMed™ 670G system. METHODS This was a pilot randomized, double-blinded, cross-over study among established MiniMed™ 670G users comparing percent time in range (TIR) and hypoglycemia for Novolog® and Fiasp®. Following two weeks optimization with their home insulin, participants were randomized to receive Novolog® or Fiasp® for two weeks, followed by the other insulin for the next two weeks. Read More

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http://dx.doi.org/10.1089/dia.2020.0083DOI Listing

Molecular and clinical characteristics of very-long-chain acyl-CoA dehydrogenase deficiency: A single-center experience in Saudi Arabia.

Saudi Med J 2020 Jun;41(6):590-596

Department of Pediatrics, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To describe the clinical and molecular characteristics of patients with very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency.   Methods: A retrospective observational cross-sectional analysis was conducted on all patients with VLCAD deficiency at  (Genetic/Metabolic Section), Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia from 2000 to 2019. Demographic, clinical, and laboratory data were abstracted from the electronic hospital records using a case report form. Read More

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http://dx.doi.org/10.15537/smj.2020.6.25131DOI Listing

Glucagon Administration by Nasal and Intramuscular Routes in Adults With Type 1 Diabetes During Insulin-Induced Hypoglycaemia: A Randomised, Open-Label, Crossover Study.

Diabetes Ther 2020 Jul 8;11(7):1591-1603. Epub 2020 Jun 8.

Profil, Mainz, Germany.

Introduction: Many commercially available glucagon products for treatment of severe hypoglycaemia require cumbersome reconstitution and potentially intimidating injection during an emergency. Nasal glucagon (NG) is a novel drug-device combination product consisting of a single-use dosing device that delivers glucagon dry powder through nasal administration. The present study assessed whether 3 mg NG was non-inferior to 1 mg intramuscular glucagon (IMG) in adults with type 1 diabetes. Read More

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http://dx.doi.org/10.1007/s13300-020-00845-7DOI Listing

Emerging roles of autophagy in hepatic tumorigenesis and therapeutic strategies in glycogen storage disease type Ia: A review.

J Inherit Metab Dis 2020 May 31. Epub 2020 May 31.

Glycogen Storage Disease Program, Department of Pediatrics, University of Connecticut School of Medicine, Farmington, Connecticut, USA.

Glycogen storage disease type Ia (GSD-Ia) is an inherited metabolic disease caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC) which plays a critical role in blood glucose homeostasis by catalyzing the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate in the terminal step of glycogenolysis and gluconeogenesis. Patients with GSD-Ia manifest life-threatening fasting hypoglycemia along with the excessive accumulation of hepatic glycogen and triglycerides which results in hepatomegaly and a risk of long-term complications such as hepatocellular adenoma and carcinoma (HCA/HCC). The etiology of HCA/HCC development in GSD-Ia, however, is unknown. Read More

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http://dx.doi.org/10.1002/jimd.12267DOI Listing
May 2020
3.365 Impact Factor

Clinical, biochemical, molecular and therapeutic characteristics of four new patients of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency.

Clin Chim Acta 2020 May 26;509:83-90. Epub 2020 May 26.

Department of Endocrinology, Genetics and Metabolism, Beijing Children's Hospital, Beijing 100045, China. Electronic address:

Thirty patients with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS) deficiency, which is a rare autosomal recessive disorder caused by HMGCS2 gene mutation are known. Here, we present four new patients with this disease. The characteristics including several metabolites of patients were recorded. Read More

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http://dx.doi.org/10.1016/j.cca.2020.04.004DOI Listing
May 2020
2.824 Impact Factor

Assessment of distance from skin surface to muscle for evaluation of the risk of inadvertent intramuscular insulin injection at potential injection sites among patients attending a tertiary care children's hospital in Sri Lanka-an observational study.

Arch Pediatr 2020 Jul 24;27(5):244-249. Epub 2020 May 24.

Department of Pharmacology and Pharmacy, Faculty of Medicine, University of Colombo, Sri Lanka.

Background: Insulin therapy is essential for type 1 diabetes. While a reasonable glycemic control prevents complications, inadvertent intramuscular (IM) insulin injection results in hypoglycemia and fluctuations of blood glucose levels.

Objective: To assess the subcutaneous thickness (SCt) at the potential insulin injection sites, in order to determine the suitable needle length. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.05.008DOI Listing

Report: central diabetes insipidus and schwannoma in a male with X-linked congenital adrenal hypoplasia.

BMC Endocr Disord 2020 May 27;20(1):73. Epub 2020 May 27.

Department of Pediatrics, Gyeongsang National University School of Medicine, 92 Chilam-dong, Jinju, Gyeongnam, 660-751, South Korea.

Background: DAX1 mutations are related to the X-linked form of adrenal hypoplasia congenita (AHC) in infancy and to hypogonadotropic hypogonadism (HH) in puberty. We report a male patient affected by X-linked AHC who presented with central diabetes insipidus and schwannoma in adulthood, which has not been described in association with AHC.

Case Presentation: A 36-day-old male infant who presented with severe dehydration was admitted to the intensive care unit. Read More

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http://dx.doi.org/10.1186/s12902-020-00553-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254651PMC

Electroclinical spectrum of childhood epilepsy secondary to neonatal hypoglycemic brain injury in a low resource setting: A 10-year experience.

Seizure 2020 Jul 20;79:90-94. Epub 2020 May 20.

Neurology Division, Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India.

Purpose: Neonatal hypoglycemic brain injury (NHBI) is being increasingly recognized as an important cause of drug resistant childhood epilepsy in low resource settings. We report the electro-clinical spectrum of children with epilepsy secondary to NHBI.

Methods: This was a retrospective study of children enrolled in the Epilepsy Clinic from January 2009 to August 2019. Read More

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http://dx.doi.org/10.1016/j.seizure.2020.05.010DOI Listing
July 2020
2.059 Impact Factor

Frequency of Abnormal Glucose Tolerance Test Suggestive of Dumping Syndrome Following Oesophageal Atresia Repair.

J Pediatr Gastroenterol Nutr 2020 Jun;70(6):820-824

This work is dedicated in memoriam of Dr Laurent Michaud.

Objectives: Dumping syndrome (DS) is mostly described as a complication of antireflux surgery in oesophageal atresia (OA) but we previously reported 2 cases of DS before any other surgery in infants operated at birth for OA. The objectives of the present study were to assess the prevalence of abnormal oral glucose tolerance test (OGTT) at 3 months of age in infants operated at birth with type C OA, to describe symptoms and clinical features, and to assess risk factors in infants presenting with abnormal OGTT suggestive of DS.

Methods: A prospective case series study including infants with type C OA without fundoplication, born between 2013 and 2016 in 8 centres was conducted. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002651DOI Listing

Effectiveness and Safety of Fast Enteral Advancement in Preterm Infants Between 1000 and 2000 g of Birth Weight.

JPEN J Parenter Enteral Nutr 2020 May 22. Epub 2020 May 22.

Pediatrics Department, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Cra 7#40-62, Bogotá, 11001, Colombia.

Background: The advancement of enteral nutrition in premature infants is still controversial. Clinicians must provide adequate caloric intake but avoiding feeding intolerance and necrotizing enterocolitis (NEC). The aim of this study was to establish the safety and effectiveness of fast enteral advancement by comparing it with traditional advancement. Read More

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http://dx.doi.org/10.1002/jpen.1925DOI Listing

Acute Disulfiram Poisoning in a Child: A Case Report and Review of Literature.

Indian J Crit Care Med 2020 Mar;24(3):203-205

Department of Pharmacology, Pandit Bhagwat Dayal Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.

Aim: To determine the significance of acute disulfiram poisoning in pediatric population.

Background: Disulfiram poisoning in children is uncommon, can occur in children who have ingested large amount of drug because of careless and unsafe storage. Only few cases have been reported in literature. Read More

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http://dx.doi.org/10.5005/jp-journals-10071-23371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225768PMC

Efficacy and Safety of Insulin Glargine 300 Units/mL (Gla-300) Versus Insulin Glargine 100 Units/mL (Gla-100) in Children and Adolescents (6-17 years) With Type 1 Diabetes: Results of the EDITION JUNIOR Randomized Controlled Trial.

Diabetes Care 2020 Jul 19;43(7):1512-1519. Epub 2020 May 19.

UMC - University Children's Hospital and Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Objective: To compare efficacy and safety of insulin glargine 300 units/mL (Gla-300) and 100 units/mL (Gla-100) in children and adolescents (6-17 years old) with type 1 diabetes.

Research Design And Methods: EDITION JUNIOR was a noninferiority, international, open-label, two-arm, parallel-group, phase 3b trial. Participants were randomized 1:1 to Gla-300 or Gla-100, titrated to achieve fasting self-monitored plasma glucose levels of 90-130 mg/dL (5. Read More

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http://dx.doi.org/10.2337/dc19-1926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305011PMC

The ketogenic diet for infants: How long can you go?

Epilepsy Res 2020 Aug 6;164:106339. Epub 2020 May 6.

Department of Pediatrics and Adolescent Health, Medical University Vienna, Austria.

Purpose: Ketogenic diets (KD) are high-fat, low-carbohydrate therapies, established in the treatment for drug-resistant epilepsy in childhood since the 1920ies. This review focuses on the use of ketogenic diet therapies in young childhood with an emphasis on the most recent advances.

Findings: The KD has been used effectively and safely in childhood, and has increasingly been offered in infancy during the last decade. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2020.106339DOI Listing

Nasal glucagon - a new way to treat severe hypoglycemia in patients with diabetes.

Pediatr Endocrinol Diabetes Metab 2020 May 18:45-57. Epub 2020 May 18.

Medical University of Lodz, Department of Pediatrics, Diabetology, Endocrinology and Nephrology, Poland.

Hypoglycaemia is the most frequent acute complication of diabetes in patients treated with insulin. Severe hypoglycaemia can lead to life-threatening disorders. In addition, fear of hypoglycaemia remains a major obstacle to achieving therapeutic goals in diabetics, espe-cially with type 1. Read More

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http://dx.doi.org/10.5114/pedm.2020.94390DOI Listing

Neonatal Hypoglycemia: GLOW at the End of the Tunnel?

J Pediatr 2020 May 13. Epub 2020 May 13.

Congenital Hyperinsulinism Center, Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2020.03.056DOI Listing

Depression as a predictor of hypoglycemia worry in parents of youth with recent-onset type 1 diabetes.

Pediatr Diabetes 2020 Aug 29;21(5):909-916. Epub 2020 May 29.

Center for Healthcare Delivery Science, Nemours Children's Health System, Jacksonville, Florida, USA.

Background: During the recent-onset period of type 1 diabetes (T1D), parents may be at increased risk for depression, stress, and hypoglycemia fear; however, current studies have not examined the parental psychological experience and anxiety from hypoglycemia fear (ie, hypoglycemia worry) over time. This study examined the trajectory of parental hypoglycemia worry (Hypoglycemia Fear Survey-Worry [HFS-Worry]) in families of children with recent-onset T1D and the effects of baseline parental depression on parents' trajectory of HFS-Worry.

Methods: We enrolled 128 families of children ages 5- to 9-years-old with recent onset T1D in this study. Read More

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http://dx.doi.org/10.1111/pedi.13039DOI Listing

Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD): a phase 2, multicentre, double-blind, randomized, placebo-controlled trial.

Wellcome Open Res 2020 20;5:49. Epub 2020 Mar 20.

Islet Transplant Research Group, Nuffield Department of Surgical Sciences, Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, OX3 9DU, UK.

Type 1 diabetes is a common autoimmune disease due to destruction of pancreatic β cells, resulting in lifelong need for insulin. Evidence suggest that maintaining residual β-cell function can improve glucose control and reduce risk of hypoglycaemia and vascular complications. Non-clinical, preclinical and some preliminary clinical data suggest that low-dose interleukin-2 (IL-2) therapy could block pancreatic β cells destruction by increasing the number of functional regulatory T cells (Tregs) that inhibit islet-specific autoreactive effector T cells (Teffs). Read More

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http://dx.doi.org/10.12688/wellcomeopenres.15697.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194454PMC

A novel frameshift PHKA2 mutation in a family with glycogen storage disease type IXa: A first report in Vietnam and review of literature.

Clin Chim Acta 2020 May 7;508:9-15. Epub 2020 May 7.

Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet str., Cau Giay, Hanoi 100000, Viet Nam; Institute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet str., Cau Giay, Hanoi 100000, Viet Nam. Electronic address:

Background: Glycogen storage diseases (GSDs) are clinically and genetically heterogeneous disorders. Overlapping features between liver GSDs are a major challenge in the clinical diagnosis of them. Genetic testing can provide an early and accurate diagnosis of patients suspected with GSDs. Read More

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http://dx.doi.org/10.1016/j.cca.2020.05.010DOI Listing
May 2020
2.824 Impact Factor

Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study.

Sci Rep 2020 May 8;10(1):7804. Epub 2020 May 8.

Department of Pediatrics, Kyorin University, Tokyo, Japan.

Our aim was to evaluate the association between ritodrine and magnesium sulfate (MgSO) and the occurrence of neonatal hyperkalemia or hypoglycemia among late preterm infants in a retrospective cohort study. We used a nationwide obstetrical database from 2014. A total of 4,622 live preterm infants born at 32-36 gestational weeks participated. Read More

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http://dx.doi.org/10.1038/s41598-020-64687-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210882PMC

PERSISTENT ASYMPTOMATIC SEVERE HYPOGLYCAEMIA DUE TO TYPE 0A GLYCOGENOSIS - GENERAL AND ORO-DENTAL ASPECTS.

Acta Endocrinol (Buchar) 2019 Oct-Dec;15(4):526-530

"Alessandrescu-Rusescu" National Institute for Mother and Child Health - Romanian Medical Association - Research, Bucharest, Romania.

Background: Type 0 glycogenosis is a genetic metabolic disorder characterized by the absence of glycogen synthesis of hepatic synthase and hence of liver glycogen stores in normal amounts. It is an extremely rare condition.

Case Study: This case is a 5-year and 11-month-old female child with asymptomatic severe hypoglycemia in the last two years. Read More

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http://dx.doi.org/10.4183/aeb.2019.526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200112PMC

Risk Factor Assessment and the Incidence of Neonatal Hypoglycemia in the Postnatal Period.

Sisli Etfal Hastan Tip Bul 2019 28;53(4):389-394. Epub 2019 Nov 28.

Department of Pediatrics, Division of Neonatology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Objectives: The aim of this study was to evaluate risk factors used for the assessment of neonatal hypoglycemia and to examine the follow-up outcomes observed in the first 48 hours of postnatal life.

Methods: The records of infants born between 2015 and 2017 (3 years) at Şişli Hamidiye Etfal Training and Research Hospital who had a blood glucose level test performed within the first 24 hours after birth and who had follow-up results for 48 hours were included in the study. Data of gestational age; birth weight; gender; antenatal, natal and postnatal characteristics; blood glucose measurement method and time during the first 48 hours postpartum; glucose values and follow-up; nutritional status; and the need for hospitalization due to a low blood glucose value were recorded. Read More

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http://dx.doi.org/10.14744/SEMB.2019.08634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192288PMC
November 2019

Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance.

Nat Commun 2020 May 1;11(1):2165. Epub 2020 May 1.

Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, 77030, USA.

Brain glucose-sensing neurons detect glucose fluctuations and prevent severe hypoglycemia, but mechanisms mediating functions of these glucose-sensing neurons are unclear. Here we report that estrogen receptor-α (ERα)-expressing neurons in the ventrolateral subdivision of the ventromedial hypothalamic nucleus (vlVMH) can sense glucose fluctuations, being glucose-inhibited neurons (GI-ERα) or glucose-excited neurons (GE-ERα). Hypoglycemia activates GI-ERα neurons via the anoctamin 4 channel, and inhibits GE-ERα neurons through opening the ATP-sensitive potassium channel. Read More

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http://dx.doi.org/10.1038/s41467-020-15982-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195451PMC

Clinical and Sociodemographic Factors Associated With Human Donor Milk Supplementation in Term Newborns.

Hosp Pediatr 2020 Jun 1;10(6):489-495. Epub 2020 May 1.

Department of Pediatrics, Doernbecher Children's Hospital, Portland, Oregon

Objectives: To identify differences between healthy term newborns supplemented with human donor milk (HDM) and those supplemented with infant formula. We hypothesized that sociodemographic and clinical distinctions exist between newborns receiving different milk types.

Methods: This retrospective study included term newborns admitted to the postpartum unit between March 2017 and April 2019 with ≥1 supplemental feeding with HDM or formula for indications other than hypoglycemia. Read More

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http://dx.doi.org/10.1542/hpeds.2019-0259DOI Listing

A Randomized Control Trial of Oral Sucrose Solution for Prevention of Hypoglycemia in High Risk Infants.

In Vivo 2020 May-Jun;34(3):1493-1497

Department of Pediatrics, Phramongkutklao Hospital and Phramongkutklao College of Medicine, Bangkok, Thailand

Background: Neonatal hypoglycemia is found in up to 15% of neonates and 50% of those with risk factors. Hypoglycemia can cause brain damage and increase risk of developmental delay. Nevertheless, the data regarding hypoglycemia prevention by oral sucrose are still limited. Read More

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http://dx.doi.org/10.21873/invivo.11935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279851PMC
February 2020

Assessing heart rate variability in type 1 diabetes mellitus-Psychosocial stress a possible confounder.

Ann Noninvasive Electrocardiol 2020 Apr 30:e12760. Epub 2020 Apr 30.

Department of Clinical Physiology, Region Kalmar County, Kalmar, Sweden.

Background: Autonomic neuropathy (AN) commonly arises as a long-term complication in diabetes mellitus and can be diagnosed from heart rate variability (HRV), calculated from electrocardiogram recordings. Psychosocial stress also affects HRV and could be one of several confounders for cardiac AN. The present work investigated the impact of psychosocial stress on HRV in individuals with type 1 diabetes mellitus (T1DM) and assessed the use of salivary cortisol as a biomarker for psychosocial stress in this context. Read More

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http://dx.doi.org/10.1111/anec.12760DOI Listing

Pregnancy outcomes in women with onset of type 1 diabetes mellitus less than 18 years of age.

BMJ Open Diabetes Res Care 2020 Apr;8(1)

Department of Paediatrics, University Hospital Limerick, Dooradoyle, Limerick, Ireland.

Background: Pregnancy in women with type 1 diabetes mellitus (T1DM) is associated with an increased risk of congenital malformations, obstetric complications and neonatal morbidity. This study aims to investigate maternal, perinatal and neonatal outcomes of pregnancies in women with onset of T1DM less than 18 years of age.

Methods: This retrospective cohort study extracted data regarding prenatal, intrapartum and postnatal outcomes of pregnancies in women with onset of T1DM<18 years identified from the diabetes in pregnancy register at University Maternity Hospital Limerick, treated from July 1, 2007 to July 1, 2017. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-001080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213751PMC

Rare association of Beckwith-Wiedemann syndrome with Hirschsprung's disease in an infant with hypoglycemia.

BMJ Case Rep 2020 Apr 26;13(4). Epub 2020 Apr 26.

Department of Pediatrics, Jehangir Hospital, Pune, Maharashtra, India.

Hypoglycaemic due to congenital hyperinsulinism in Beckwith-Wiedemann syndrome is commonly seen. It is usually transient and is managed by enteral feeds, high glucose-containing intravenous fluids and medications like diazoxide. We describe a case of an infant with genetically proven Beckwith-Wiedemann syndrome with prolonged hyperinsulinemic hypoglycaemia. Read More

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http://dx.doi.org/10.1136/bcr-2020-235121DOI Listing

A novel homozygous missense mutation in three CACT-deficient patients: clinical and autopsy data.

Hum Genome Var 2020 16;7:11. Epub 2020 Apr 16.

1Department of Child Health and Welfare (Pediatrics), Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa Japan.

Carnitine-acylcarnitine translocase (CACT) deficiency is a fatty acid ß-oxidation disorder of the carnitine shuttle in mitochondria, with a high mortality rate in childhood. We evaluated three patients, including two siblings, with neonatal-onset CACT deficiency and revealed identical homozygous missense mutations of p.Arg275Gln within the gene. Read More

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http://dx.doi.org/10.1038/s41439-020-0098-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162975PMC

Type 1 diabetes and epilepsy in childhood and adolescence: Do glutamic acid decarboxylase autoantibodies play a role? Data from the German/Austrian/Swiss/Luxembourgian DPV Registry.

Pediatr Diabetes 2020 Aug 7;21(5):766-773. Epub 2020 May 7.

Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology, University of Ulm, Ulm, Germany.

Aims: We aimed to analyze the relationship between epilepsy and glutamic acid decarboxylase autoantibodies (GADA) in patients with type 1 diabetes mellitus (T1DM) and the impact of GADA on demographic, clinical, and metabolic data in T1DM patients with epilepsy.

Methods: We searched for patients with T1DM ≤20 years and GADA measurements, and within this group for patients with epilepsy. We formed groups: T1DM + Epilepsy + GADA positive; T1DM + Epilepsy + GADA negative; T1DM + GADA positive; T1DM + GADA negative. Read More

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http://dx.doi.org/10.1111/pedi.13034DOI Listing

Diabetes management in Wolcott-Rallison syndrome: analysis from the German/Austrian DPV database.

Orphanet J Rare Dis 2020 Apr 22;15(1):100. Epub 2020 Apr 22.

Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany.

Background: Wolcott-Rallison syndrome (WRS) is characterized by permanent early-onset diabetes, skeletal dysplasia and several additional features, e.g. recurrent liver failure. Read More

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http://dx.doi.org/10.1186/s13023-020-01359-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178620PMC

Insulin/carbohydrates ratio during the first 6-month therapy with insulin degludec in a paediatric population with type 1 diabetes previously treated with insulin glargine. An observational longitudinal study.

Endocrinol Diabetes Metab 2020 Apr 12;3(2):e00121. Epub 2020 Mar 12.

Department of Pediatrics University of Chieti Chieti Italy.

Background: No data exist about the changes induced by the transition from first-generation long-acting insulins to second-generation long-acting analogues in the paediatric population.

Objective: To assess changes in insulin/carbohydrate ratio (I:CHO) after the first 6 months of degludec therapy in a paediatric population with type 1 diabetes previously treated with glargine U100.

Subjects: All patients treated with degludec under routine clinical practice conditions were retrospectively analysed. Read More

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http://dx.doi.org/10.1002/edm2.121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170455PMC

Effectiveness and safety of flexible therapeutic schemes including first- and secondgeneration basal insulins during a pediatric summer diabetes camp.

Pediatr Rep 2020 Feb 7;12(1):8254. Epub 2020 Apr 7.

Department of Pediatrics University of Chieti.

Outcomes of insulin analogues in pediatric diabetes camps are poorly investigated; no data is available about insulin degludec (IDeg).Our aim was to assess impact of insulin therapy adopted by the participants to a 4-day diabetes camp held in 2017, hypothesizing a possible excess risk of hypoglycemia in patients treated with IDeg. Overall, 40 children with type 1 diabetes (mean age 13. Read More

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http://dx.doi.org/10.4081/pr.2020.8254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160858PMC
February 2020

Episodes of severe hypoglycemia is associated with a progressive increase in hemoglobin A1c in children and adolescents with type 1 diabetes.

Pediatr Diabetes 2020 Aug 4;21(5):808-813. Epub 2020 May 4.

Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.

Objective: To investigate the trajectory in glycemic control following episodes of severe hypoglycemia (SH) among children and adolescents with type 1 diabetes (T1D).

Methods: A Danish national population-based study comprising data from 2008-17. SH was defined according to the 2014 ISPAD guidelines. Read More

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http://dx.doi.org/10.1111/pedi.13020DOI Listing

Hypoglycaemia: a hidden risk in paediatric colonoscopy.

Arch Dis Child 2020 Apr 17. Epub 2020 Apr 17.

Department of Anaesthetics, Oxford University Hospitals NHS Trust, Oxford, Oxfordshire, UK.

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http://dx.doi.org/10.1136/archdischild-2019-318713DOI Listing

Continuous glucose monitor use with and without remote monitoring in pregnant women with type 1 diabetes: A pilot study.

PLoS One 2020 16;15(4):e0230476. Epub 2020 Apr 16.

Barbara Davis Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.

Background: To examine whether continuous glucose monitoring (CGM) with remote monitoring by followers (family/friends) changes glucose management, follower interventions, and health outcomes compared to CGM alone in pregnant women with diabetes.

Methods: We prospectively stratified first trimester pregnant women with Type 1 Diabetes to CGM Share (remote monitoring) or CGM Alone. We enrolled a main follower per woman. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230476PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162510PMC

Treating neutropenia and neutrophil dysfunction in glycogen storage disease IB with an SGLT2-inhibitor.

Blood 2020 Apr 15. Epub 2020 Apr 15.

Walloon Excellence in Lifesciences and Biotechnology, B-1200 Brussels, Belgium., Belgium.

Neutropenia and neutrophil dysfunction cause serious infections and inflammatory bowel disease in glycogen storage disease Ib (GSD-Ib). Our discovery that accumulating 1,5-anhydroglucitol-6-phosphate causes neutropenia in a G6PC3-deficient mouse model and in the two rare diseases (GSD-Ib and G6PC3-deficiency) led us to repurpose the widely used antidiabetic drug empagliflozin, an inhibitor of the renal glucose co-transporter SGLT2. Off-label use of empagliflozin in four GSD-Ib patients with incomplete response to granulocyte colony stimulating factor (GCSF) treatment decreased serum 1,5-anhydroglucitol and neutrophil 1,5-anhydroglucitol-6-phosphate levels within one month. Read More

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http://dx.doi.org/10.1182/blood.2019004465DOI Listing