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    Insulin delivery and nocturnal glucose control in children and adolescents with type 1 diabetes.
    Expert Opin Drug Deliv 2017 Aug 18:1-11. Epub 2017 Aug 18.
    a Wellcome Trust-MRC Institute of Metabolic Science , University of Cambridge , Cambridge , UK.
    Introduction: Nocturnal glucose control remains challenging in children and adolescents with type 1 diabetes due to highly variable overnight insulin requirements. The issue may be addressed by glucose responsive insulin delivery based on real-time continuous glucose measurements. Areas covered: This review outlines recent developments of glucose responsive insulin delivery systems from a paediatric perspective. Read More

    Clinical practice guidelines for congenital hyperinsulinism.
    Clin Pediatr Endocrinol 2017 27;26(3):127-152. Epub 2017 Jul 27.
    Department of Pediatric Surgery, Tohoku University, Miyagi, Japan.
    Congenital hyperinsulinism is a rare condition, and following recent advances in diagnosis and treatment, it was considered necessary to formulate evidence-based clinical practice guidelines reflecting the most recent progress, to guide the practice of neonatologists, pediatric endocrinologists, general pediatricians, and pediatric surgeons. These guidelines cover a range of aspects, including general features of congenital hyperinsulinism, diagnostic criteria and tools for diagnosis, first- and second-line medical treatment, criteria for and details of surgical treatment, and future perspectives. These guidelines were generated as a collaborative effort between The Japanese Society for Pediatric Endocrinology and The Japanese Society of Pediatric Surgeons, and followed the official procedures of guideline generation to identify important clinical questions, perform a systematic literature review (April 2016), assess the evidence level of each paper, formulate the guidelines, and obtain public comments. Read More

    Association of Neonatal Glycemia With Neurodevelopmental Outcomes at 4.5 Years.
    JAMA Pediatr 2017 Aug 7. Epub 2017 Aug 7.
    Liggins Institute, The University of Auckland, Auckland, New Zealand.
    Importance: Hypoglycemia is common during neonatal transition and may cause permanent neurological impairment, but optimal intervention thresholds are unknown.

    Objective: To test the hypothesis that neurodevelopment at 4.5 years is related to the severity and frequency of neonatal hypoglycemia. Read More

    [Identification of a novel mutation of AGL gene in two siblings affected with glycogen storage disease type IIIa].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2017 Aug;34(4):499-503
    Department of Pediatrics, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China.
    Objective: To detect potential mutation of the AGL gene in two siblings affected with glycogen storage disease type IIIa.

    Methods: Clinical data of the two siblings was collected and analyzed. Genomic DNA was extracted from peripheral venous blood samples from the patients and their parents. Read More

    Closed-Loop Control Without Meal Announcement in Type 1 Diabetes.
    Diabetes Technol Ther 2017 Aug 2. Epub 2017 Aug 2.
    1 Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute , Troy, New York.
    Objective: A fully closed-loop insulin-only system was developed to provide glucose control in patients with type 1 diabetes without requiring announcement of meals or activity. Our goal was to assess initial safety and efficacy of this system.

    Research Design And Methods: The multiple model probabilistic controller (MMPPC) anticipates meals when the patient is awake. Read More

    Incidence of severe hypoglycemia in children with type 1 diabetes in the Nordic countries in the period 2008-2012: association with hemoglobin A 1c and treatment modality.
    BMJ Open Diabetes Res Care 2017 29;5(1):e000377. Epub 2017 May 29.
    Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Children and Adolescents, Copenhagen University Hospital, Herlev, Denmark.
    Objective: Treatment of type 1 diabetes has been intensified aiming at normalizing blood glucose, which may increase the risk of severe hypoglycemia (SH). We aimed to compare the incidence of SH events in the four Nordic countries Denmark, Iceland, Norway and Sweden, and to assess the influence of hemoglobin A1c (HbA1c) and treatment modalities on the frequency of SH; particularly, to explore if a HbA1c target ≤6.7% (50 mmol/mol) is feasible. Read More

    Successful treatment of a newborn with congenital hyperinsulinism having a novel heterozygous mutation in the ABCC8 gene using subtotal pancreatectomy.
    Ci Ji Yi Xue Za Zhi 2016 Oct-Dec;28(4):162-165. Epub 2016 May 27.
    Department of Pediatrics, MacKay Children Hospital, Taipei, Taiwan.
    Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in newborns and infants. CHI is characterized by unregulated secretion of insulin from pancreatic β: cells. Here, we reported the case of a large-for-gestational-age, full-term newborn that suffered from CHI and developed severe and persistent hypoglycemia at an early stage of life. Read More

    Hereditary Tyrosinemia Type 1 in Turkey.
    Adv Exp Med Biol 2017 ;959:157-172
    Cerrahpasa Medical Faculty, Central Laboratories, Metabolic Diseases Unit, University of Istanbul, 34098, Kocamustafapasa Fatih, Istanbul, Turkey.
    Hereditary tyrosinemia type 1 (HT1, OMIM 276700) is a rare autosomal recessively inherited inborn error of metabolism in the tyrosine catabolic pathway due to deficiency of the enzyme fumarylacetoacetate hydrolase. The clinical features of HT1 are widely heterogenous even within the same family members. Clinical features includes acute or chronic liver disease with increased risk of hepatocellular carcinoma, hypophosphatemic rickets due to renal tubular dysfunction, glomerulosclerosis, failure to thrive, neurological porphyria-like crisis, hypertrophic cardiomyopathy and hypoglycemia due to hyperinsulinism. Read More

    Neurodevelopmental Outcome of Asymptomatic Hypoglycemia Compared With Symptomatic Hypoglycemia and Euglycemia in High-Risk Neonates.
    Pediatr Neurol 2017 Sep 7;74:74-79. Epub 2017 Jun 7.
    Neonatal Unit, Department of Pediatrics, PGIMER, Chandigarh, India.
    Aims: We assessed the neurodevelopmental outcome at one year of age of children with asymptomatic neonatal hypoglycemia and compared their outcome with that of symptomatic hypoglycemic and euglycemic neonates.

    Method: Seventy two hypoglycemic (plasma glucose less than 50 mg/dL) neonates, both symptomatic (n = 27) and asymptomatic (n = 45), and 70 weight- and gestation-matched euglycemic neonates of gestational age greater than 32 weeks were enrolled during the first week of life then assessed for neurodevelopmental outcome at corrected age six and 12 months (n = 67 and 62 in hypoglycemia group and 63 and 54 in euglycemia group, with the rest lost to follow-up, and death = 1).

    Results: At one year, 8% (five of 62, four in symptomatic and one in asymptomatic group) of hypoglycemic neonates developed cerebral palsy. Read More

    Pilot study of propranolol premedication to reduce FDG uptake in brown adipose tissue on PET scans of adolescent and young adult oncology patients.
    Pediatr Hematol Oncol 2017 Jul 20:1-8. Epub 2017 Jul 20.
    a Department of Pediatrics , University of Kentucky , Lexington , Kentucky , USA.
    Objective: Physiologic uptake of (18)F-fluorodeoxyglucose (FDG) in brown adipose tissue (adipose tissue) of cancer patients may confound interpretation of positron emission tomography (PET) scans. Uptake in adipose tissue occurs in up to half of pediatric oncology patients undergoing PET scans, and is especially common in adolescents. adipose tissue is innervated by the sympathetic nervous system, and beta blockers such as propranolol have shown efficacy in reducing adipose tissue uptake on PET scans done in older adult oncology patients. Read More

    Population Pharmacokinetics of Diazoxide in Children with Hyperinsulinemic Hypoglycemia.
    Horm Res Paediatr 2017 Jul 14. Epub 2017 Jul 14.
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.
    Background: Diazoxide is the first-line treatment for pediatric hyperinsulinemic hypoglycemia (HI). This study aimed to elucidate the pharmacokinetics of diazoxide in children with HI.

    Methods: We obtained 81 blood samples from 22 children with HI. Read More

    Assessing the effectiveness of a 3-month day-and-night home closed-loop control combined with pump suspend feature compared with sensor-augmented pump therapy in youths and adults with suboptimally controlled type 1 diabetes: a randomised parallel study protocol.
    BMJ Open 2017 Jul 13;7(7):e016738. Epub 2017 Jul 13.
    Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
    Introduction: Despite therapeutic advances, many individuals with type 1 diabetes are unable to achieve tight glycaemic target without increasing the risk of hypoglycaemia. The objective of this study is to determine the effectiveness of a 3-month day-and-night home closed-loop glucose control combined with a pump suspend feature, compared with sensor-augmented insulin pump therapy in youths and adults with suboptimally controlled type 1 diabetes.

    Methods And Analysis: The study adopts an open-label, multi-centre, multi-national (UK and USA), randomised, single-period, parallel design and aims for 84 randomised patients. Read More

    POSTPRANDIAL DOSING OF BOLUS INSULIN IN PATIENTS WITH TYPE 1 DIABETES: A CROSS-SECTIONAL STUDY USING DATA FROM THE T1D EXCHANGE REGISTRY.
    Endocr Pract 2017 Jul 13. Epub 2017 Jul 13.
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT, US.
    Objective: To assess the prevalence and characteristics of patients with type 1 diabetes who dose bolus insulin postprandial (PostP) versus preprandial (PreP).

    Methods: Data for this cross-sectional study were obtained from 21,533 participants in the T1D Exchange registry. Data were drawn from the enrollment questionnaire. Read More

    Efficacy and safety of octreotide for the treatment of congenital hyperinsulinism: a prospective, open-label clinical trial and an observational study in Japan using a nationwide registry.
    Endocr J 2017 Jul 11. Epub 2017 Jul 11.
    Division of Pediatric Endocrinology and Metabolism, Children's Medical Center, Osaka City General Hospital, Osaka 534-0021, Japan.
    Octreotide, a long-acting somatostatin analog, has been used for treating hypoglycemia caused by congenital hyperinsulinism (CHI). However, octreotide has not been evaluated in clinical trials and has not been approved in any developed country. We aimed to test the efficacy and safety of octreotide for diazoxide-unresponsive CHI through a combination of a single-arm, open-label clinical trial (SCORCH study) and an observational study to collect data on the clinical course of patients treated off-label in Japan (SCORCH registry). Read More

    Maternal use of prednisolone is unlikely to be associated with neonatal adrenal suppression-a single-center study of 16 cases.
    Eur J Pediatr 2017 Aug 10;176(8):1131-1136. Epub 2017 Jul 10.
    Department of Pediatrics, University Medical Center Groningen, Groningen, Netherlands.
    The use of supra-physiological, exogenous corticosteroids in pregnancy may lead to neonatal adrenal suppression. We report on a single-center, case series study carried out between 2006 and 2014, which included all newborns (n = 16) of mothers using prednisolone ≥10 mg/day during pregnancy. Newborns were routinely assessed according to hospital protocol, with follow-up until 6 weeks after birth. Read More

    Where technology does not go: specialised neonatal care in resource-poor and conflict-affected contexts.
    Public Health Action 2017 Jun;7(2):168-174
    Medical Department, Médecins Sans Frontières (MSF) Operational Centre Brussels, Brussels, Belgium.
    Setting: Although neonatal mortality is gradually decreasing worldwide, 98% of neonatal deaths occur in low- and middle-income countries, where hospital care for sick and premature neonates is often unavailable. Médecins Sans Frontières Operational Centre Brussels (MSF-OCB) managed eight specialised neonatal care units (SNCUs) at district level in low-resource and conflict-affected settings in seven countries. Objective: To assess the performance of the MSF SNCU model across different settings in Africa and Southern Asia, and to describe the set-up of eight SNCUs, neonate characteristics and clinical outcomes among neonates from 2012 to 2015. Read More

    Clinical assessment of the lag-time and tmax of pellets with controlled release of glucose: in vitro/in vivo comparison using (13) C-breath test.
    Biopharm Drug Dispos 2017 Jul 3. Epub 2017 Jul 3.
    Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1, 612 00, Brno, Czech Republic.
    Maintaining a stable glycaemia in diabetes mellitus type 1 requires flexible insulin administration and carbohydrate intake to affected individuals. In real life, there might be some situations limiting the insulin-sugar balance control, e.g. Read More

    Screening for Hypoglycemia in Exclusively Breastfed High-risk Neonates.
    Indian Pediatr 2017 Jun;54(6):477-480
    Department of Pediatrics, LLRM Medical College, Meerut, UP; and *Department of Biostatistics, AIIMS, New Delhi; India. Correspondence to: Dr Amit Upadhyay, Department of Pediatrics, LLRM Medical College, Meerut, India.
    Objective: To determine incidence of hypoglycemia in exclusively breastfed, high-risk but healthy newborns, and risk factors for its development.

    Methods: This observational study enrolled 407 exclusively breastfed high-risk (low birth weight newborns (1800-2499 g), late preterms, small-for-gestation, large-for-gestation and infant of diabetic mother), who did not require admission to neonatal intensive care unit and were kept in postnatal wards with mother. Hypoglycemia was defined as blood glucose £46 mg/dL (2. Read More

    Comparable glycemic outcomes for pediatric type 1 diabetes patients in metropolitan and non-metropolitan regions of Western Australia: A population-based study.
    Pediatr Diabetes 2017 Jun 30. Epub 2017 Jun 30.
    Department of Endocrinology and Diabetes, Princess Margaret Hospital, Perth, Australia.
    Background: Pediatric patients diagnosed with type 1 diabetes (T1D) in Western Australia (WA) are managed by a single, specialist multidisciplinary diabetes service based at a central tertiary hospital in the capital city, Perth, which provides outreach care in regional centers.

    Objective: To investigate the hypothesis that outcomes for a contemporary, population-based pediatric T1D cohort, managed by a single tertiary service are similar for metropolitan and non-metropolitan patients using this model of care. To confirm that the cohort is indeed population based, a secondary aim of the study was to determine the case ascertainment of the Western Australian Children's Diabetes Database (WACDD). Read More

    Biopsychosocial Aspects of Weight Management in Type 1 Diabetes: a Review and Next Steps.
    Curr Diab Rep 2017 Aug;17(8):58
    Department of Nutrition, The University of North Carolina Chapel Hill, Chapel Hill, NC, 27599-7461, USA.
    Purpose Of Review: This review aims to summarize the type 1 diabetes (T1D) and weight literature with an emphasis on barriers associated with weight management, the unique T1D-specific factors that impact weight loss success, maladaptive and adaptive strategies for weight loss, and interventions to promote weight loss.

    Recent Findings: Weight gain is associated with intensive insulin therapy. Overweight and obese weight status in individuals with T1D is higher than the general population and prevalence is rising. Read More

    Continuous Glucose Monitoring in Pediatrics: The Gap between Potential Benefits and the Reality of Utility.
    Pediatr Endocrinol Rev 2017 Jun;14(Suppl 2):435-440
    Diabetes Center for Children at The Children's Hospital of Philadelphia, 34th Street and Civic Center Blvd, Philadelphia, PA 19342, USA.
    Continuous Glucose Monitoring (CGM) is rapidly becoming a standard of care in the management of Type 1 diabetes (T1D). Today's devices are nearly as accurate as home glucose meters. They provide glucose data every 5 minutes, alert to high and low blood glucose levels, and allow for remote monitoring of a user's glucose data and patterns. Read More

    Relationship between Measures of Neonatal Glycemia, Neonatal Illness, and 2-Year Outcomes in Very Preterm Infants.
    J Pediatr 2017 Jun 21. Epub 2017 Jun 21.
    Liggins Institute, University of Auckland, Auckland, New Zealand. Electronic address:
    Objectives: To investigate relationships between early neonatal glycemia, neonatal characteristics, neonatal illness, and developmental outcomes in very preterm infants.

    Study Design: A retrospective, observational cohort study of 443 infants born weighing <1500 g or <30 weeks of gestation, and admitted within 24 hours to National Women's Hospital, Auckland, New Zealand. Glucose variability was defined as the standard deviation around the mean after log transformation of all blood glucose concentrations. Read More

    Characterization of the concurrent metabolic changes in brain and plasma during insulin-induced moderate hypoglycemia using (1)H NMR spectroscopy in juvenile rats.
    Neurosci Lett 2017 Jul 14;653:370-375. Epub 2017 Jun 14.
    Division of Neonatology, Department of Pediatrics, University of Minnesota, Mayo Mail Code 39, 420 Delaware Street, SE, Minneapolis, MN 55455, USA; Center for Neurobehavioral Development, University of Minnesota, Mayo Mail Code 39, 420 Delaware Street, SE, Minneapolis, MN 55455, USA. Electronic address:
    Treatment of hypoglycemia in children is currently based on plasma glucose measurements. This approach may not ensure neuroprotection since plasma glucose does not reflect the dynamic state of cerebral energy metabolism. To determine whether cerebral metabolic changes during hypoglycemia could be better characterized using plasma metabolomic analysis, insulin-induced acute hypoglycemia was induced in 4-week-old rats. Read More

    Self-care management of type 1 diabetes has improved in Swedish schools according to children and adolescents.
    Acta Paediatr 2017 Jun 13. Epub 2017 Jun 13.
    Department of Paediatrics, University Hospital Örebro, Örebro, Sweden.
    Aim: Age-appropriate support for diabetes self-care is essential during school time, and we investigated the perceived quality of support children and adolescents received in 2015 and 2008.

    Methods: This national study was based on questionnaires answered by children and adolescents aged 6-15 years of age with type 1 diabetes attending schools or preschools in 2008 (n = 317) and 2015 (n = 570) and separate parental questionnaires. The subjects were recruited by Swedish paediatric diabetes units, with 41/44 taking part in 2008 and 41/42 in 2015. Read More

    Diagnosis of congenital hyperinsulinism: Biochemical profiles during hypoglycemia.
    Pediatr Diabetes 2017 Jun 9. Epub 2017 Jun 9.
    Division of Pediatric Endocrinology and Metabolism, Children's Medical Center, Osaka City General Hospital, Osaka, Japan.
    Objectives: To define the ranges of biochemical markers during hypoglycemia for the diagnosis of congenital hyperinsulinism (CHI), using high sensitivity insulin assays.

    Subjects: A total of 298 patients with CHI and 58 control patients with non-hyperinsulinemic hypoglycemia, who were diagnosed after 2007.

    Methods: The levels of biochemical markers (glucose, insulin, β-hydroxybutyrate [BHB], free fatty acids [FFA], lactate, ammonia) at the time of hypoglycemia were analyzed along with the maximal glucose infusion rate (GIR) to maintain euglycemia and clinical outcomes. Read More

    A 10-second sprint does not blunt hormonal counter-regulation to subsequent hypoglycaemia.
    Diabet Med 2017 Jun 6. Epub 2017 Jun 6.
    Telethon Kids Institute, Perth, WA, Australia.
    Aim: To investigate whether a 10-second (s) sprint impairs the counter-regulatory response to subsequent hypoglycaemia.

    Methods: Nine people (five male, four female) with Type 1 diabetes, aged 21.1 ± 4. Read More

    A heterozygous microdeletion of 20p12.2-3 encompassing PROKR2 and BMP2 in a patient with congenital hypopituitarism and growth hormone deficiency.
    Am J Med Genet A 2017 Aug 6;173(8):2261-2267. Epub 2017 Jun 6.
    Manchester Academic Health Sciences Centre, Centre for Paediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester, UK.
    Congenital growth hormone deficiency is a rare disorder with an incidence of approximately 1 in 4,000 live births. Pituitary development is under the control of a multitude of spatiotemporally regulated signaling molecules and transcription factors. Mutations in the genes encoding these molecules can result in hypopituitarism but for the majority of children with congenital hypopituitarism, the aetiology of their disease remains unknown. Read More

    C-Section Prevalence Among Obese Mothers and Neonatal Hypoglycemia: a Cohort Analysis of the Department of Gynecology and Obstetrics of the University of Lübeck.
    Geburtshilfe Frauenheilkd 2017 May 24;77(5):487-494. Epub 2017 May 24.
    Westpfalz-Klinikum GmbH, Kaiserslautern, Germany.
    Introduction: Data from the World Health Organization (WHO) demonstrates an increasing prevalence of obesity in Western countries. This study investigates the influence of obesity on the mode of delivery and the occurrence of hypoglycemia in newborns.

    Materials And Methods: A retrospective analysis of all deliveries at the Department of Gynecology and Obstetrics of the University of Lübeck, Germany was conducted over a period of eleven years with the primary outcome as non-elective C-sections and hypoglycemia of newborns from obese mothers. Read More

    Treatment with long-acting lanreotide autogel in early infancy in patients with severe neonatal hyperinsulinism.
    Orphanet J Rare Dis 2017 Jun 2;12(1):108. Epub 2017 Jun 2.
    Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital Duesseldorf, Moorenstrasse 5, 40225, Duesseldorf, Germany.
    Background: Treatment of severe diffuse congenital hyperinsulinism (CHI) without sufficient response to diazoxide is complicated by the lack of approved drugs. Therefore, patients are often hospitalized long-term or have to undergo pancreatic surgery if episodes of severe hypoglycaemia cannot be prevented. A long-acting somatostatin analogue, octreotide, has been reported to be an effective treatment option that prevents severe hypoglycaemia in children with CHI, and its off-label use is common in CHI. Read More

    Prevention of complications in glycogen storage disease type Ia with optimization of metabolic control.
    Pediatr Diabetes 2017 Aug 1;18(5):327-331. Epub 2017 Jun 1.
    Glycogen Storage Disease Program, Connecticut Children's Medical Center, Hartford, Connecticut.
    Prior to 1971, type Ia glycogen storage disease was marked by life-threatening hypoglycemia, lactic acidosis, severe failure to thrive, and developmental delay. With the introduction of continuous feeds in the 1970s and cornstarch in the 1980s, the prognosis improved, but complications almost universally developed. Changes in the management of type Ia glycogen storage disease have resulted in improved metabolic control, and this manuscript reviews the increasing evidence that complications can be delayed or prevented with optimal metabolic control as previously was seen in diabetes. Read More

    Recurrent insulinoma in a 10-year-old boy with Down's syndrome.
    Endocrinol Diabetes Metab Case Rep 2017 24;2017. Epub 2017 May 24.
    King Faisal Specialist Hospital and Research Centre, Pediatrics, Jeddah, SASaudi Arabia.
    An insulinoma is a rare tumour with an incidence of four cases per million per year in adults. The incidence in children is not established. There is limited literature available in children with insulinoma, and only one case is reported in association with Down's syndrome in adults. Read More

    Bowel management program for pediatric postoperative fecal incontinence in China: A surgeon's experience.
    Medicine (Baltimore) 2017 Jun;96(22):e7078
    aSouthern Medical University bDepartment of Pediatric Surgery cInstitute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
    The purpose of this article is to report the status of the efficacy of and long-term adherence to the Bowel Management Program (BMP) for fecal incontinence (FI) postoperation in China.Children over 3 years of age with FI postoperation referred to our medical center were included in the study. Evaluations were performed before and 2 years after their clinic visit. Read More

    Sporadic Insulinoma Presenting as Early Morning Night Terrors.
    Pediatrics 2017 Jun;139(6)
    Departments of Pediatrics and
    A 16-year-old boy with a recent diagnosis of night terrors was evaluated for recurrent early morning hypoglycemia after an early morning seizure. Evaluation in clinic with critical laboratories identified hyperinsulinemic hypoglycemia. Additional investigation revealed a sporadic insulinoma as the etiology of his hypoglycemia and all symptoms were resolved after pancreaticoduodenectomy. Read More

    Intractable Hypoglycemia in the Setting of Autoimmune Overlap Syndrome.
    Pediatrics 2017 Jun 10;139(6). Epub 2017 May 10.
    Division of Pediatric Endocrinology and.
    Evaluation of hypoglycemia in a patient with known diabetes mellitus, although usually straightforward, can at times be challenging. We present the case of an 8 year-old Latina girl initially diagnosed with type 1 diabetes mellitus in the setting of multiple autoimmune disorders, including dermatomyositis and lupus nephritis. She subsequently developed signs of insulin resistance and severe hypoglycemia, which was found to be due to insulin-receptor autoantibodies. Read More

    Blood Glucose Control and Related Factors at a Camp for Korean Children and Adolescents with Type 1 Diabetes.
    Compr Child Adolesc Nurs 2017 May 30:1-13. Epub 2017 May 30.
    a Department of Nursing , Inha University , Incheon , South Korea.
    Data about Asian children and adolescents with type 1 diabetes are sparse. This study's objectives were to describe blood glucose (BG) levels and related factors at a camp for Korean children and adolescents with type 1 diabetes. This descriptive study was conducted January 8-10, 2015. Read More

    Atenolol Versus Propranolol for Treatment of Infantile Hemangiomas During the Proliferative Phase: A Retrospective Noninferiority Study.
    Pediatr Dermatol 2017 Jul 28;34(4):413-421. Epub 2017 May 28.
    Department of Cardiology, Connecticut Children's Medical Center, Hartford, Connecticut.
    Background/objectives: The nonselective beta-blocker propranolol is the current criterion standard for treatment of infantile hemangiomas (IHs) and the first therapy that the U.S. Food and Drug Administration has approved for the condition, but concern about adverse effects, such as bronchospasm, hypoglycemia, and sleep disturbances, has sparked interest in the use of alternative agents such as the selective β1 antagonist atenolol. Read More

    Insulin glulisine for continuous subcutaneous insulin infusion in pediatric type 1 diabetes.
    Pediatr Int 2017 May;59(5):647-649
    Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan.
    We evaluated the efficacy and safety of insulin glulisine (GLU) used for continuous s.c. insulin infusion (CSII) in 20 children with type 1 diabetes after 1 year of GLU treatment. Read More

    Dextrose gel treatment does not impair subsequent feeding.
    Arch Dis Child Fetal Neonatal Ed 2017 May 23. Epub 2017 May 23.
    Liggins Institute, University of Auckland, Auckland, New Zealand.
    Background: Dextrose gel is increasingly used as first-line treatment for neonatal hypoglycaemia. Treatment with 400 mg/kg previously has been reported to impair subsequent feeding. We sought to determine if the recommended dose of 200 mg/kg altered feeding. Read More

    Glycated albumin level during late pregnancy as a predictive factor for neonatal outcomes of women with diabetes.
    J Matern Fetal Neonatal Med 2017 Jun 9:1-6. Epub 2017 Jun 9.
    a Department of Pediatrics , Saitama Medical Center Jichi Medical University , Saitama , Japan.
    Purpose: To investigate the association between glycated albumin (GA) in diabetic mothers and complications in their children, and to determine GA cutoff values for predicting complications in infants.

    Materials And Methods: This hospital-based case-control study involved 71 Japanese diabetic mothers and their children. Mean GA values were compared between mothers of infants with and without complications, and relationship with number of complications was analyzed by Pearson's correlation. Read More

    Change in hemoglobin A1c one year following the 2014 American Diabetes Association guideline update.
    Diabetes Res Clin Pract 2017 Jul 10;129:169-172. Epub 2017 May 10.
    Department of Pediatrics, University of Colorado School of Medicine, United States; The Barbara Davis Center for Childhood Diabetes, Aurora, CO, United States.
    Aims: In June 2014, the American Diabetes Association lowered recommended hemoglobin A1c (HbA1c) targets from <8.5% (69mmol/mol) for children <6years of age and from <8.0% (64mmol/mol) for children 6-12years of age to <7. Read More

    Effectiveness of SmartGuard Technology in the Prevention of Nocturnal Hypoglycemia After Prolonged Physical Activity.
    Diabetes Technol Ther 2017 May;19(5):299-304
    1 Department of Pediatrics, University Hospital Motol and 2nd Faculty of Medicine, Charles University in Prague , Czech Republic .
    Background: The prevention of postexercise nocturnal hypoglycemia after prolonged physical activity using sensor-augmented pump (SAP) therapy with predictive low-glucose management (PLGM) has not been well studied. We conducted a study at a pediatric diabetes camp to determine whether a SAP with PLGM reduces the frequency of nocturnal hypoglycemia after prolonged physical activity more effectively than a SAP with a carbohydrate intake algorithm.

    Methods: During a 1-week sport camp, 20 children (aged 10-13 years) with type 1 diabetes (T1D) managed by SAP therapy either with (n = 7) or without PLGM (n = 13) were studied. Read More

    Relationship between Glycemic Levels and Treatment Outcome among Critically Ill Children admitted into Emergency Room in Enugu.
    BMC Pediatr 2017 May 16;17(1):126. Epub 2017 May 16.
    Department of Pediatric, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria.
    Background: Critically ill children are those in need of immediate attention on arrival to an emergency room. The importance of glycemic level measurement as well as maintaining the patency of the airway, effective breathing and circulation cannot be overemphasied. It has been highlighted that the peak hyperglycemia and hypoglycemia predict poor prognosis, longer lengths of hospital stay and higher mortality. Read More

    Real-life experience of patients starting insulin degludec. A multicenter analysis of 1064 subjects from the German/Austrian DPV registry.
    Diabetes Res Clin Pract 2017 Jul 4;129:52-58. Epub 2017 May 4.
    Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.
    Background: The long-acting insulin analogue degludec is a therapeutic option for patients with type 1 (T1D) or type 2 diabetes (T2D). Aim of this analysis was to investigate differences in clinical characteristics of patients before and after initiating degludec use in a cohort of German/Austrian patients.

    Methods: 1064 subjects with T1D/T2D and documented degludec use from the Diabetes-Patient-Follow-Up (DPV) registry were included. Read More

    Continuous Subcutaneous Insulin Infusion in Children: A Pilot Study Validating a Protocol to Avoid Hypoglycemia at Initiation.
    Front Endocrinol (Lausanne) 2017 24;8:84. Epub 2017 Apr 24.
    Endocrinology Service and Diabetes Unit, CHU Sainte-Justine, Montreal, QC, Canada.
    Background: The occurrence of hypoglycemia and hyperglycemia during the first days after transition to continuous subcutaneous insulin infusion (CSII) in patients with type 1 diabetes has not been systematically studied in children. The aim of this prospective study was to demonstrate that the protocol applied in our diabetes clinic is safe at CSII initiation in children.

    Methods: We assessed 22 pediatric patients with type 1 diabetes, using continuous glucose monitoring (CGM) before and after CSII initiation (±3 days). Read More

    Dietary intake and risk of non-severe hypoglycemia in adolescents with type 1 diabetes.
    J Diabetes Complications 2017 Aug 20;31(8):1340-1347. Epub 2017 Apr 20.
    Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA; Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address:
    Aims: To determine the association between dietary intake and risk of non-severe hypoglycemia in adolescents with type 1 diabetes.

    Methods: Type 1 adolescents from a randomized trial wore a blinded continuous glucose monitoring (CGM) system at baseline for one week in free-living conditions. Dietary intake was calculated as the average from two 24-h dietary recalls. Read More

    A Case Report of Hypoglycemia and Hypogammaglobulinemia: DAVID syndrome in a patient with a novel NFKB2 mutation.
    J Clin Endocrinol Metab 2017 May 3. Epub 2017 May 3.
    Division of Allergy, Immunology & Rheumatology, Departments of Pediatrics, Stanford University School of Medicine, Stanford, California.
    Context: DAVID syndrome (Deficient Anterior pituitary with Variable Immune Deficiency) is a rare disorder in which children present with symptomatic ACTH deficiency preceded by hypogammaglobulinemia from B-cell dysfunction with recurrent infections, termed common variable immunodeficiency (CVID). Subsequent whole exome sequencing studies have revealed germline heterozygous C-terminal mutations of NFKB2 as either a cause of DAVID syndrome or of CVID without clinical hypopituitarism. However, to the best of our knowledge there have been no cases in which the endocrinopathy has presented in the absence of a prior clinical history of CVID. Read More

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