2,874 results match your criteria Pediatrics Hypoglycemia


Sotos Syndrome Presenting with Neonatal Hyperinsulinaemic Hypoglycaemia, Extensive Thrombosis, and Multisystem Involvement.

Horm Res Paediatr 2019 Mar 15:1-7. Epub 2019 Mar 15.

Department of Endocrinology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.

Initially described as an uncommon presenting feature of Sotos syndrome (SoS), over the last decades, congenital hyperinsulinaemic hypoglycaemia (CHI) has been increasingly reported in association with this condition. The mechanism responsible for CHI in SoS is unclear. We report the case of a neonate presenting with CHI and extensive venous and arterial thrombosis associated with kidney, heart, liver, skeleton, and brain abnormalities and finally diagnosed with SoS on whole genome sequencing. Read More

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http://dx.doi.org/10.1159/000496545DOI Listing

Pregnancy Outcomes of Women Additionally Diagnosed as Gestational Diabetes by the International Association of the Diabetes and Pregnancy Study Groups Criteria.

Diabetes Metab J 2019 Feb 28. Epub 2019 Feb 28.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background: We investigated the pregnancy outcomes in women who were diagnosed with gestational diabetes mellitus (GDM) by the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria but not by the Carpenter-Coustan (CC) criteria.

Methods: A total of 8,735 Korean pregnant women were identified at two hospitals between 2014 and 2016. Among them, 2,038 women participated in the prospective cohort to investigate pregnancy outcomes. Read More

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https://e-dmj.org/DOIx.php?id=10.4093/dmj.2018.0192
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http://dx.doi.org/10.4093/dmj.2018.0192DOI Listing
February 2019
1 Read

The Genetic and Molecular Mechanisms of Congenital Hyperinsulinism.

Front Endocrinol (Lausanne) 2019 26;10:111. Epub 2019 Feb 26.

Division of Endocrinology, Department of Paediatric Medicine, Sidra Medicine, Doha, Qatar.

Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic hypoglycaemia. The severity of hypoglycaemia varies depending on the underlying molecular mechanism and genetic defects. The genetic and molecular causes of CHI include defects in pivotal pathways regulating the secretion of insulin from the beta-cell. Read More

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http://dx.doi.org/10.3389/fendo.2019.00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401612PMC
February 2019

Morbidity Patterns of Late Preterm Babies Born Small for Gestation.

Indian J Pediatr 2019 Mar 13. Epub 2019 Mar 13.

Department of Pediatrics, Armed Forces Medical College, Pune, India.

Objective: To compare hypoglycemia and the other early neonatal morbidities (from birth till hospital discharge) of late preterm babies born small for gestational age (LP SGA) with their appropriate for age (LP AGA) counterparts.

Methods: LP SGA and LP AGA, as defined by Fenton charts, were prospectively followed-up to assess development of predefined morbidities, mortality and readmission rates at one month. All live inborn late preterm babies (34 to 36 weeks, n = 238) were included. Read More

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http://dx.doi.org/10.1007/s12098-019-02925-4DOI Listing
March 2019
0.919 Impact Factor

Bezafibrate Enhances AAV Vector-Mediated Genome Editing in Glycogen Storage Disease Type Ia.

Mol Ther Methods Clin Dev 2019 Jun 10;13:265-273. Epub 2019 Feb 10.

Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

Glycogen storage disease type Ia (GSD Ia) is a rare inherited disease caused by mutations in the glucose-6-phosphatase (G6Pase) catalytic subunit gene (). Absence of G6Pase causes life-threatening hypoglycemia and long-term complications because of the accumulations of metabolic intermediates. Bezafibrate, a pan-peroxisome proliferator-activated receptor (PPAR) agonist, was administered in the context of genome editing with a zinc-finger nuclease-containing vector (AAV-ZFN) and a G6Pase donor vector (AAV-RoG6P). Read More

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http://dx.doi.org/10.1016/j.omtm.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395830PMC

Lower plasma insulin levels during overnight closed-loop in school children with type 1 diabetes: Potential advantage? A randomized cross-over trial.

PLoS One 2019 8;14(3):e0212013. Epub 2019 Mar 8.

Pediatric Clinic, Centre Hospitalier de Luxembourg, Luxembourg, GD de Luxembourg.

Background: Studies have shown that overnight closed-loop insulin delivery can improve glucose control and reduce the risk of hypoglycemia and hence may improve metabolic outcomes and reduce burden for children with type 1 diabetes and their families. However, research so far has not reported insulin levels while comparing closed-loop to open-loop insulin delivery in children. Therefore, in this study we obtained glucose levels as well as plasma insulin levels in children with type 1 diabetes to evaluate the efficacy of a model-based closed-loop algorithm compared to an open-loop administration. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212013PLOS
March 2019
2 Reads

Glycemic control and complications in glycogen storage disease type I: Results from the Swiss registry.

Mol Genet Metab 2019 Feb 28. Epub 2019 Feb 28.

Department of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland; radiz - Rare Disease Initiative Zurich, Clinical Research Priority Program for Rare Diseases, University of Zurich, Switzerland. Electronic address:

Background: Regular carbohydrate intake to avoid hypoglycemia is the mainstay of dietary treatment in glycogen storage disease type I (GSDI). The aim of this study was to evaluate the quality of dietary treatment and glycemic control in a cohort of GSDI patients, in relation to the presence of typical long-term complications.

Methods: Data of 25 patients (22 GSD subtype Ia and 3 GSDIb, median age 20y) from the Swiss hepatic glycogen storage disease registry was analyzed cross-sectionally. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10967192193003
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http://dx.doi.org/10.1016/j.ymgme.2019.02.008DOI Listing
February 2019
6 Reads

Hypoglycemia in unmonitored full-term newborns-a surveillance study.

Paediatr Child Health 2018 Dec 10;23(8):509-514. Epub 2018 Mar 10.

Department of Pediatrics, Queen's University.

Background And Objectives: Hypoglycemia monitoring is not recommended for most full-term newborns. We wished to determine the incidence, presentation and case characteristics of hypoglycemia in low-risk newborns.

Methods: With the assistance of the Canadian Paediatric Surveillance Program, we conducted a national study of severe hypoglycemia in apparently low-risk full-term newborns. Read More

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https://academic.oup.com/pch/article/23/8/509/4925979
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http://dx.doi.org/10.1093/pch/pxy025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242033PMC
December 2018
4 Reads

A Feasibility Study to Detect Neonatal Hypoglycemia in Infants of Diabetic Mothers Using Real-Time Continuous Glucose Monitoring.

Diabetes Technol Ther 2019 Mar 6. Epub 2019 Mar 6.

1 Department of Pediatrics, Division of Pediatric Endocrinology, Stanford University, Stanford, California.

Background: Infants born to mothers with diabetes commonly experience asymptomatic hypoglycemia after birth. Continuous glucose monitors (CGM) can detect asymptomatic hypoglycemia in this population without the need for painful glucose checks.

Methods: Infants born after 34 weeks of gestation to mothers with diabetes had a CGM placed after birth. Read More

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http://dx.doi.org/10.1089/dia.2018.0337DOI Listing

The effects of the treatment conditions on the dissolution profile of ethylcellulose coated pellets.

Eur J Pharm Sci 2019 Feb 28;132:86-95. Epub 2019 Feb 28.

Department of Pharmaceutics, University of Veterinary and Pharmaceutical Sciences, Palackeho tr. 1946/1, 612 42 Brno, Czech Republic.

Due to the additional particle coalescence in the coating, changes in the dissolution profile occur over time in the formulations coated by aqueous ethylcellulose latex. Dry thermal treatment (DT) of the coating can be used as a prevention of this process. Alternatively, it is advisable to take advantage of the synergistic effect of high humidity during wet treatment (WT), which substantially accelerates the film formation. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.02.034DOI Listing
February 2019
1 Read
3.350 Impact Factor

Hypoglycemia in the Newborn.

Pediatr Clin North Am 2019 04 1;66(2):333-342. Epub 2019 Feb 1.

Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

This article covers several aspects of the clinical management of neonatal hypoglycemia that have recently evolved, reviewing the evidence informing these recommended changes in practice. Topics covered include use of buccal dextrose gel, rationale for avoiding the traditional "mini dextrose bolus," and benefits of direct breastfeeding for the treatment of asymptomatic hypoglycemia in at-risk newborns. The reasons for increasing use of more accurate point-of-care devices for measuring neonatal glucose concentrations are discussed, as well as the implications of different published opinions regarding the determination of readiness for discharge and the most important considerations when making this determination. Read More

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http://dx.doi.org/10.1016/j.pcl.2018.12.004DOI Listing
April 2019
1 Read

Hypovolemic Shock in a Child: A Pediatric Simulation Case.

MedEdPORTAL 2018 Mar 16;14:10694. Epub 2018 Mar 16.

Professor, Department of Pediatrics, Robert Larner, MD, College of Medicine at the University of Vermont.

Introduction: Volume depletion is a common problem in pediatrics. Interns need to be able to recognize critical illness such as hypovolemic shock, obtain access, and manage complications. This simulation case involves a child with hypovolemic shock who requires intraosseous (IO) needle placement. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342355PMC
March 2018
2 Reads

Alleles of Insm1 determine whether RIP1-Tag2 mice produce insulinomas or nonfunctioning pancreatic neuroendocrine tumors.

Oncogenesis 2019 Feb 22;8(3):16. Epub 2019 Feb 22.

Raymond and Beverly Sackler Foundation Laboratory, New Brunswick, NJ, USA.

The two most common types of pancreatic neuroendocrine tumors (PanNETs) are insulinomas and nonfunctioning PanNETs (NF-PanNETs). Insulinomas are small, rarely metastatic tumors that secrete high amounts of insulin, and nonfunctioning PanNETs are larger tumors that are frequently metastatic but that do not secrete hormones. Insulinomas are modeled by the highly studied RIP1-Tag2 (RT2) transgenic mice when bred into a C57Bl/6 (B6) genetic background (also known as RT2 B6 mice). Read More

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http://dx.doi.org/10.1038/s41389-019-0127-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386750PMC
February 2019

Short-Term Adverse Outcomes Associated With Hypoglycemia in Critically Ill Children.

Crit Care Med 2019 Feb 14. Epub 2019 Feb 14.

Division of Medical Critical Care, Department of Pediatrics, Boston Children's Hospital, Boston, MA.

Objectives: Previous studies report worse short-term outcomes with hypoglycemia in critically ill children. These studies relied on intermittent blood glucose measurements, which may have introduced detection bias. We analyzed data from the Heart And Lung Failure-Pediatric INsulin Titration trial to determine the association of hypoglycemia with adverse short-term outcomes in critically ill children. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003699DOI Listing
February 2019
2 Reads

[Hypoglycaemia unawareness in patients with type 1 diabetes].

Pediatr Endocrinol Diabetes Metab 2018 ;2018(3):126-134

Chair and Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, Poland.

Hypoglycaemia unawareness, defined at the onset of neuroglycopenia before the appearance of autonomic warning symptoms, is an serious problem in type 1 diabetes mellitus. It is often caused by recurrent or severe hypoglycaemia, which leads to the failure of the autonomic nervous system (hypoglycaemia-associated autonomic failure - HAAF). The hypoglycaemia awareness can be restored by avoiding episodes of hypoglycaemia. Read More

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http://dx.doi.org/10.5114/pedm.2018.80994DOI Listing
January 2018
2 Reads

Hyperinsulinaemic hypoglycaemia: A new presentation of 16p11.2 deletion syndrome.

Clin Endocrinol (Oxf) 2019 Feb 18. Epub 2019 Feb 18.

Endocrinology Department, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1111/cen.13951DOI Listing
February 2019
1 Read
3.457 Impact Factor

Whole exome sequencing revealed mutations in FBXL4, UNC80, and ADK in Thai patients with severe intellectual disabilities.

Gene 2019 Feb 14;696:21-27. Epub 2019 Feb 14.

Center of Excellence for Medical Genomics, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand; Excellence Center for Medical Genetics, King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok 10330, Thailand.

Intellectual disabilities (ID) are etiologically heterogeneous. Advanced molecular techniques could be helpful in identification of the underlying genetic defects. We aimed to characterize clinical and molecular features of three Thai patients with ID. Read More

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http://dx.doi.org/10.1016/j.gene.2019.01.049DOI Listing
February 2019

Assessing patient-reported outcomes for automated insulin delivery systems: the psychometric properties of the INSPIRE measures.

Diabet Med 2019 Feb 14. Epub 2019 Feb 14.

Bournemouth University, Bournemouth, UK.

Aim: Participants in clinical trials assessing automated insulin delivery systems report perceived benefits and burdens that reflect their experiences and may predict their likelihood of uptake and continued use of this novel technology. Despite the importance of understanding their perspectives, there are no available validated and reliable measures assessing the psychosocial aspects of automated insulin delivery systems. The present study assesses the initial psychometric properties of the INSPIRE measures, which were developed for youth and adults with Type 1 diabetes, as well as parents and partners. Read More

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http://dx.doi.org/10.1111/dme.13930DOI Listing
February 2019
1 Read

Impact of NBS for VLCAD deficiency on genetic, enzymatic and clinical outcomes.

J Inherit Metab Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Metabolic Diseases, Dutch Fatty Acid Oxidation Expertise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: Most infants with very-long-chain acyl-CoA dehydrogenase deficiency (VLCADD) identified by newborn screening (NBS) are asymptomatic at the time of diagnosis and remain asymptomatic. If this outcome is due to prompt diagnosis and initiation of therapy, or because of identification of individuals with biochemical abnormalities who will never develop symptoms, is unclear.

Methods: A 10 year longitudinal national cohort study of genetically confirmed VLCADD patients born before and after introduction of NBS. Read More

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http://dx.doi.org/10.1002/jimd.12075DOI Listing
February 2019
5 Reads

School Nurses on the Front Lines of Medicine: Emergencies Associated With Sport and Physical Activities: Part 1.

NASN Sch Nurse 2019 Feb 9:1942602X18819223. Epub 2019 Feb 9.

Professor, Departments of Emergency Medicine and Pediatrics, Penn State College of Medicine.

Illness and injury associated with sport and physical activities may occur in the school setting. Although most sport-related illness and injury in students are considered minor emergencies, life- and limb-threatening illnesses or injuries may occur, such as sudden cardiac arrest, heat stroke, status asthmaticus, catastrophic brain or cervical spine injuries, hypoglycemia, blunt chest/abdominal injuries, or extremity fractures requiring surgery. It is important for the school nurse to recognize potential life- and limb-threatening emergencies associated with sport and physical activity, to initiate stabilization of the student with life- and limb-threatening symptoms, and to triage these students to an appropriate level of care (back to the classroom, home with their guardian with follow up at their primary healthcare provider's office, or directly to the closest emergency department via emergency medical services). Read More

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http://dx.doi.org/10.1177/1942602X18819223DOI Listing
February 2019
2 Reads

Mitochondrial disorders.

Ann Transl Med 2018 Dec;6(24):475

Children's Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Primary mitochondrial disorders are a group of clinically variable and heterogeneous inborn errors of metabolism (IEMs), resulting from defects in cellular energy, and can affect every organ system of the body. Clinical presentations vary and may include symptoms of fatigue, skeletal muscle weakness, exercise intolerance, short stature, failure to thrive, blindness, ptosis and ophthalmoplegia, nystagmus, hearing loss, hypoglycemia, diabetes mellitus, learning difficulties, intellectual disability, seizures, stroke-like episodes, spasticity, dystonia, hypotonia, pain, neuropsychiatric symptoms, gastrointestinal reflux, dysmotility, gastrointestinal pseudo-obstruction, cardiomyopathy, cardiac conduction defects, and other endocrine, renal, cardiac, and liver problems. Most phenotypic manifestations are multi-systemic, with presentations varying at different age of onset and may show great variability within members of the same family; making these truly complex IEMs. Read More

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http://dx.doi.org/10.21037/atm.2018.12.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331360PMC
December 2018
3 Reads

Glycogen metabolism and glycogen storage disorders.

Ann Transl Med 2018 Dec;6(24):474

Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Glucose is the main energy fuel for the human brain. Maintenance of glucose homeostasis is therefore, crucial to meet cellular energy demands in both - normal physiological states and during stress or increased demands. Glucose is stored as glycogen primarily in the liver and skeletal muscle with a small amount stored in the brain. Read More

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http://dx.doi.org/10.21037/atm.2018.10.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331362PMC
December 2018
3 Reads

Fatty acid oxidation disorders.

Ann Transl Med 2018 Dec;6(24):473

Department of Pediatrics and Adolescent Medicine, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI, USA.

Fatty acid oxidation disorders (FAODs) are inborn errors of metabolism due to disruption of either mitochondrial β-oxidation or the fatty acid transport using the carnitine transport pathway. The presentation of a FAOD will depend upon the specific disorder, but common elements may be seen, and ultimately require a similar treatment. Initial presentations of the FAODs in the neonatal period with severe symptoms include cardiomyopathy, while during infancy and childhood liver dysfunction and hypoketotic hypoglycemia are common. Read More

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http://dx.doi.org/10.21037/atm.2018.10.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331364PMC
December 2018
1 Read

International Consensus on Risk Management of Diabetic Ketoacidosis in Patients with Type 1 Diabetes Treated with Sodium-Glucose Cotransporter (SGLT) Inhibitors.

Diabetes Care 2019 Feb 6. Epub 2019 Feb 6.

Diabetes Centre for Children and Adolescents, AUF DER BULT, Kinder- und Jugendkrankenhaus, Hannover, Germany.

Sodium glucose cotransporter (SGLT) inhibitors are new oral antidiabetic medications shown to effectively reduce glycated hemoglobin (A1C) and glycemic variability, blood pressure and body weight without intrinsic properties to cause hypoglycemia in people with type 1 diabetes. However, recent studies, particularly in individuals with type 1 diabetes, have demonstrated increases in the absolute risk of diabetic ketoacidosis (DKA). Some cases presented with near-normal blood glucose levels or mild hyperglycemia, complicating the recognition/diagnosis of DKA and potentially delaying treatment. Read More

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-231
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http://dx.doi.org/10.2337/dc18-2316DOI Listing
February 2019
14 Reads

SIADH versus adrenal insufficiency: a life-threatening misdiagnosis.

Ital J Pediatr 2019 Feb 6;45(1):23. Epub 2019 Feb 6.

University of Trieste, Piazzale Europa, 1, 34127, Trieste, Italy.

Background: Primary adrenal insufficiency (PAI) in children is an uncommon but severe condition which can be either inherited or acquired. It consists in clinical manifestation of defective production or ineffective action of endogenous glucocorticoids; deficiency in mineralocorticoids and adrenal androgens may coexist. Diagnosis of PAI in children and young people can be challenging; while adrenal crisis (acute decompensation) is a life-threatening condition, with patient presenting with characteristic features of hypoglycemia, hypotension, collapse and coma, chronic adrenal insufficiency may present with vague and non-specific symptoms, making the diagnosis more difficult. Read More

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http://dx.doi.org/10.1186/s13052-019-0614-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366080PMC
February 2019
7 Reads

Hyperinsulinemic hypoglycemia in seven patients with de novo NSD1 mutations.

Am J Med Genet A 2019 Apr 4;179(4):542-551. Epub 2019 Feb 4.

Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Sotos syndrome is an overgrowth syndrome characterized by distinctive facial features and intellectual disability caused by haploinsufficiency of the NSD1 gene. Genotype-phenotype correlations have been observed, with major anomalies seen more frequently in patients with 5q35 deletions than those with point mutations in NSD1. Though endocrine features have rarely been described, transient hyperinsulinemic hypoglycemia (HI) of the neonatal period has been reported as an uncommon presentation of Sotos syndrome. Read More

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http://dx.doi.org/10.1002/ajmg.a.61062DOI Listing
April 2019
6 Reads

Malglycemia is associated with poor outcomes in pediatric and adolescent hematopoietic stem cell transplant patients.

Blood Adv 2019 Feb;3(3):350-359

Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO.

Malglycemia (hypoglycemia, hyperglycemia, and/or glycemic variability) in adult hematopoietic stem cell transplant (HSCT) recipients is associated with increased infection, graft-versus-host disease, organ dysfunction, delayed engraftment, and mortality. Malglycemia has not been studied in pediatric HSCT recipients. This study aimed to characterize the incidence and consequences of malglycemia in this population. Read More

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http://www.bloodadvances.org/lookup/doi/10.1182/bloodadvance
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http://dx.doi.org/10.1182/bloodadvances.2018021014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373732PMC
February 2019
5 Reads

Home Use of Day and Night Hybrid Closed Loop Insulin Delivery in Very Young Children: A Multicenter 3-Week, Randomized Trial.

Diabetes Care 2019 Jan 28. Epub 2019 Jan 28.

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

Objective: We aimed to assess the feasibility and safety of hybrid closed loop insulin delivery in children with type 1 diabetes aged 1-7 years as well as evaluate the role of diluted insulin on glucose control.

Research Design And Methods: In an open-label, multicenter, multinational, randomized crossover study, 24 children with type 1 diabetes on insulin pump therapy (median age 5 years [interquartile range 3-6] and mean ± SD HbA 7.4 ± 0. Read More

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http://dx.doi.org/10.2337/dc18-1881DOI Listing
January 2019
2 Reads

Hyperinsulinemic Hypoglycemia in a Neonate.

Clin Chem 2019 Feb;65(2):351-353

Department of Metabolic Biochemistry, Rouen University Hospital, Rouen, France;

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http://dx.doi.org/10.1373/clinchem.2018.292326DOI Listing
February 2019
1 Read

Incidence of hypoglycemia in newborn infants identified as at risk.

J Matern Fetal Neonatal Med 2019 Jan 27:1-6. Epub 2019 Jan 27.

b Department of Pediatrics and Adolescent Medicine , Landeskrankenhaus Feldkirch , Feldkirch , Austria.

Background: Temporary low plasma glucose concentrations are common in healthy newborns. Although there is no uniform definition of neonatal hypoglycemia, there is a consensus in the current literature that plasma glucose concentrations should be measured in infants at risk. Known risk groups for transient neonatal hypoglycemia include infants of diabetic mothers (IDM), large (LGA) or small (SGA) for gestational age and late preterm (LPT) infants. Read More

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http://dx.doi.org/10.1080/14767058.2019.1568985DOI Listing
January 2019

Maternal BMI in Twin Pregnancies and Impact on Neonatal Outcomes in the Level I Unit: A Retrospective Cohort Study.

J Obstet Gynaecol Can 2019 Jan 24. Epub 2019 Jan 24.

Department of Paediatrics, Mount Sinai Hospital, Toronto, ON; Department of Paediatrics, University of Toronto, Toronto, ON; Maternal-Infant Care Research Centre, Mount Sinai Hospital, Toronto, ON. Electronic address:

Objective: With maternal obesity rates and twin pregnancies on the rise, the aim of this study was to assess the impact of pre-pregnancy or first trimester BMI on short-term neonatal morbidities in twins admitted to a level I unit.

Methods: This retrospective single-centre cohort study was conducted on twins born between January 1, 2010 and December 31, 2013 and admitted to the level I unit at Mount Sinai Hospital in Toronto, Ontario. Twin pairs were categorized according to maternal BMI: underweight (<18. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.11.011DOI Listing
January 2019
2 Reads

Exome sequencing identifies a de novo FOXA2 variant in a patient with syndromic diabetes.

Pediatr Diabetes 2019 Jan 26. Epub 2019 Jan 26.

Pediatric Endocrine and Diabetes Unit, Department of Pediatrics, University Hospitals of Geneva, Geneva, Switzerland.

Objective: When diabetes is associated with congenital malformations, without autoimmune antibodies, a genetic cause is suspected. Here, we aimed to identify a defective gene that led to diabetes.

Research Design And Methods: We performed an exome analysis of an index case and his healthy parents. Read More

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http://doi.wiley.com/10.1111/pedi.12814
Publisher Site
http://dx.doi.org/10.1111/pedi.12814DOI Listing
January 2019
7 Reads

Evaluation of Maternal Functioning in Mothers of Infants Admitted to the Neonatal Intensive Care Unit.

J Womens Health (Larchmt) 2019 Jan 25. Epub 2019 Jan 25.

8 College of Medicine, University of Toledo, Toledo, Ohio.

Objective: Factors associated with maternal functioning in biological mothers whose infants were admitted to a Neonatal Intensive Care Unit (NICU) were identified as measured by a modified version of the Barkin Index of Maternal Functioning.

Materials And Methods: This multivariable regression analysis explored sociodemographic and clinical data from 146 mother-infant dyads admitted to a Level III NICU between February 2015 and May 2016. Eligible dyads included: (1) adult biological mothers with singleton infants discharged home alive after NICU admission meeting criteria and (2) infants discharged home alive from the NICU with adult, biological mothers after a minimum 6-day admission. Read More

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http://dx.doi.org/10.1089/jwh.2018.7168DOI Listing
January 2019
2 Reads

Data electronically extracted from the electronic health record require validation.

J Perinatol 2019 Mar 24;39(3):468-474. Epub 2019 Jan 24.

Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Objectives: Determine sources of error in electronically extracted data from electronic health records.

Study Design: Categorical and continuous variables related to early-onset neonatal hypoglycemia were preselected and electronically extracted from records of 100 randomly selected neonates within 3479 births with laboratory-proven early-onset hypoglycemia. Extraction language was written by an information technologist and data validated by blinded manual chart review. Read More

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http://dx.doi.org/10.1038/s41372-018-0311-8DOI Listing

Absence of gut microbial colonization attenuates the sympathoadrenal response to hypoglycemic stress in mice: implications for human neonates.

Pediatr Res 2019 Mar 14;85(4):574-581. Epub 2019 Jan 14.

Departments of Pediatrics, Biochemistry and Molecular Biology, Division of Newborn Medicine, New York Medical College, Valhalla, NY, 10595, USA.

Background: Gut microbiota plays an important role during early development via bidirectional gut-brain signaling. Catecholamines provide a survival advantage allowing adaptation to common postnatal stressors. We aimed to explore the potential link between gut microbiota/gut-derived metabolites and sympathoadrenal stress responsivity. Read More

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http://dx.doi.org/10.1038/s41390-018-0270-yDOI Listing
March 2019
2 Reads

Is there an optimal strategy for real-time continuous glucose monitoring in pediatrics? A 12-month French multi-center, prospective, controlled randomized trial (Start-In!).

Pediatr Diabetes 2019 Jan 20. Epub 2019 Jan 20.

Pediatric Endocrinology and Diabetology Department and Centre de Référence des Maladies Endocriniennes Rares de la Croissance, CHU Robert Debré, AP-HP, Paris, France.

Aim: To compare the efficacy of three strategies for real-time continuous glucose monitoring (RT-CGM) over 12 months in children and adolescents with type 1 diabetes.

Methods: A French multicenter trial (NCT00949221) with a randomized, controlled, prospective, open, and parallel-group design was conducted. After 3 months of RT-CGM, patients were allocated to one of three groups: return to self-monitoring of blood glucose, continuous CGM (80% of the time), or discontinuous CGM (40% of the time). Read More

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http://dx.doi.org/10.1111/pedi.12820DOI Listing
January 2019
3 Reads

Safety assessment during initiation and maintenance of propranolol therapy for infantile hemangiomas.

Adv Clin Exp Med 2019 Jan 15. Epub 2019 Jan 15.

Department of Pediatric Surgery and Urology, Wroclaw Medical University, Poland.

Background: Propranolol is an effective method of treatment for infantile hemangiomas (IH). A recent concern is a shift of the therapy into outpatient settings.

Objectives: The aim of the study was to evaluate the safety of initiating and maintaining propranolol therapy for IH. Read More

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http://dx.doi.org/10.17219/acem/94136DOI Listing
January 2019
2 Reads

State of Type 1 Diabetes Management and Outcomes from the T1D Exchange in 2016-2018.

Diabetes Technol Ther 2019 Feb 18;21(2):66-72. Epub 2019 Jan 18.

8 Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado.

Objective: To provide a snapshot of the profile of adults and youth with type 1 diabetes (T1D) in the United States and assessment of longitudinal changes in T1D management and clinical outcomes in the T1D Exchange registry.

Research Design And Methods: Data on diabetes management and outcomes from 22,697 registry participants (age 1-93 years) were collected between 2016 and 2018 and compared with data collected in 2010-2012 for 25,529 registry participants.

Results: Mean HbA1c in 2016-2018 increased from 65 mmol/mol at the age of 5 years to 78 mmol/mol between ages 15 and 18, with a decrease to 64 mmol/mol by age 28 and 58-63 mmol/mol beyond age 30. Read More

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https://www.liebertpub.com/doi/10.1089/dia.2018.0384
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http://dx.doi.org/10.1089/dia.2018.0384DOI Listing
February 2019
10 Reads

Outcomes of Delaying Parenteral Nutrition for 1 Week vs Initiation Within 24 Hours Among Undernourished Children in Pediatric Intensive Care: A Subanalysis of the PEPaNIC Randomized Clinical Trial.

JAMA Netw Open 2018 Sep 7;1(5):e182668. Epub 2018 Sep 7.

Department of Pediatrics and Pediatric Surgery, Intensive Care Unit, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Importance: Undernourishment has been associated with poor outcomes of critical illness in children. The effects of withholding parenteral nutrition (PN) for 1 week in undernourished critically ill children are unknown.

Objective: To assess the outcome effects of withholding PN for 1 week in undernourished critically ill children. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2018.2668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324499PMC
September 2018
16 Reads

Preserved glucose response to low-dose glucagon after exercise in insulin-pump-treated individuals with type 1 diabetes: a randomised crossover study.

Diabetologia 2019 Apr 14;62(4):582-592. Epub 2019 Jan 14.

Department of Endocrinology, Copenhagen University Hospital Hvidovre, Kettegaard Alle 30, 2650, Hvidovre, Denmark.

Aims/hypothesis: This study aimed to compare the increase in plasma glucose after a subcutaneous injection of 200 μg glucagon given after 45 min of cycling with resting (study 1) and to investigate the effects of glucagon when injected before compared with after 45 min of cycling (study 2). We hypothesised that: (1) the glucose response to glucagon would be similar after cycling and resting; and (2) giving glucagon before the activity would prevent the exercise-induced fall in blood glucose during exercise and for 2 h afterwards.

Methods: Fourteen insulin-pump-treated individuals with type 1 diabetes completed three visits in a randomised, placebo-controlled, participant-blinded crossover study. Read More

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http://dx.doi.org/10.1007/s00125-018-4807-8DOI Listing
April 2019
2 Reads

Optimization of insulin regimen and glucose outcomes with short-term real-time continuous glucose monitoring (RT-CGM) in type 1 diabetic children with sub-optimal glucose control on multiple daily injections: The pediatric DIACCOR study.

Arch Pediatr 2019 Feb 12;26(2):95-101. Epub 2019 Jan 12.

Unité endocrinologie et diabétologie pédiatrique, université Bordeaux, CHU Bordeaux, 33000 Bordeaux, France. Electronic address:

Background: The impact of 7-day real-time continuous glucose monitoring (RT-CGM) on type 1 diabetes (T1D) management remains unknown in youths with suboptimal control by multiple daily injections (MDI). The DIACCOR Study aimed to describe treatment decisions and glucose outcomes after a short-term RT-CGM sequence in real-life conditions.

Methods: This French multicenter longitudinal observational study included T1D youths with HbA1c>7. Read More

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http://dx.doi.org/10.1016/j.arcped.2018.11.010DOI Listing
February 2019
3 Reads

Use of Continuous Glucose Monitoring Trends to Facilitate Exercise in Children with Type 1 Diabetes.

Diabetes Technol Ther 2019 Jan;21(1):51-55

1 Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, Australia.

Diabetes care during exercise frequently requires interruptions to activity and adds extra challenges particularly for young individuals with type 1 diabetes (T1D). This study investigated the use of a carbohydrate (CHO) intake algorithm based on continuous glucose monitoring (CGM) trends during physical activity. Children with T1D diagnosed for >1 year, ages 8-12 years, with a glycated hemoglobin of <10% were recruited into a randomized crossover study. Read More

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http://dx.doi.org/10.1089/dia.2018.0292DOI Listing
January 2019
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A Feasibility Study of Paired Continuous Glucose Monitoring Intrapartum and in the Newborn in Pregnancies Complicated by Type 1 Diabetes.

Diabetes Technol Ther 2019 Jan;21(1):20-27

2 Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom.

Aim: To describe the continuous glucose monitoring (CGM) profiles of type 1 diabetes (T1D) offspring in the early neonatal period and its association with maternal intrapartum glucose control.

Methods: A prospective observational study of T1D pregnant women and their neonatal offspring. Women had a CGM sensor inserted 2-3 days before delivery. Read More

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http://dx.doi.org/10.1089/dia.2018.0221DOI Listing
January 2019
1 Read

Mindfulness, Worries, and Parenting in Parents of Children With Type 1 Diabetes.

J Pediatr Psychol 2018 Dec 24. Epub 2018 Dec 24.

Department of Experimental, Clinical and Health Psychology, Ghent University.

Objective: Parents of children with type 1 diabetes (T1D) often experience distress and worries, which may negatively impact their parenting behaviors. The current study investigates parental mindfulness (i.e. Read More

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http://dx.doi.org/10.1093/jpepsy/jsy094DOI Listing
December 2018
2 Reads

Characteristics of Automated Insulin Suspension and Glucose Responses with the Predictive Low-Glucose Management System.

Diabetes Technol Ther 2019 Jan 26;21(1):28-34. Epub 2018 Dec 26.

1 Children's Diabetes Center, Telethon Kids Institute, The University of Western Australia, Perth, Australia.

Background: The Predictive Low-Glucose Management (PLGM) system suspends basal insulin when hypoglycemia is predicted and reduces hypoglycemia. The aim of this analysis was to explore the characteristics of automated insulin suspension and sensor glucose (SG) responses following PLGM-initiated pump suspension.

Research Design And Methods: Children and adolescents with type 1 diabetes used the Medtronic MiniMed™ 640G pump as part of a randomized controlled trial. Read More

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http://dx.doi.org/10.1089/dia.2018.0205DOI Listing
January 2019
3 Reads

Worse Metabolic Control and Dynamics of Weight Status in Adolescent Girls Point to Eating Disorders in the First Years after Manifestation of Type 1 Diabetes Mellitus: Findings from the Diabetes Patienten Verlaufsdokumentation Registry.

J Pediatr 2018 Dec 20. Epub 2018 Dec 20.

Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology (ZIBMT), University of Ulm, Ulm, Germany; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.

Objective: To assess indications of eating disorders in girls with type 1 diabetes mellitus (T1DM).

Study Design: In total 31 556 girls aged >6 months and <23 years of age with T1DM from the Diabetes Patienten Verlaufsdokumentation (DPV) cohort were analyzed including 155 (0.49%) girls with anorexia nervosa, 85 (0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223476183168
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http://dx.doi.org/10.1016/j.jpeds.2018.11.037DOI Listing
December 2018
6 Reads

Characterization of diabetes following pancreatic surgery in patients with congenital hyperinsulinism.

Orphanet J Rare Dis 2018 12 22;13(1):230. Epub 2018 Dec 22.

Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany.

Background: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycaemia in infancy that leads to unfavourable neurological outcome if not treated adequately. In patients with severe diffuse CHI it remains under discussion whether pancreatic surgery should be performed or intensive medical treatment with the acceptance of recurrent episodes of mild hypoglycaemia is justified. Near-total pancreatectomy is associated with high rates of insulin-dependent diabetes mellitus and exocrine pancreatic insufficiency. Read More

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http://dx.doi.org/10.1186/s13023-018-0970-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304089PMC
December 2018
2 Reads

Oral dextrose gel to treat neonatal hypoglycaemia: Clinician survey.

J Paediatr Child Health 2018 Nov 22. Epub 2018 Nov 22.

Liggins Institute, University of Auckland, Auckland, New Zealand.

Aims: To determine the use of oral dextrose gel to treat neonatal hypoglycaemia in New Zealand (NZ), to identify barriers and enablers to the implementation of the guideline and to determine if there is variation in management between clinical disciplines caring for at-risk babies.

Methods: An online survey was distributed to clinicians (including doctors, midwives and nurses) caring for babies with neonatal hypoglycaemia via stakeholders and maternity hospitals.

Results: A total of 251 clinicians from all 20 District Health Boards (DHBs) completed the survey. Read More

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http://dx.doi.org/10.1111/jpc.14306DOI Listing
November 2018
3 Reads

A Case of Reye Syndrome Caused by Influenza A Virus.

Ochsner J 2018 ;18(4):425-427

The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.

Background: Reye syndrome is a rare and potentially life-threatening disease characterized by liver failure and hepatic encephalopathy. Multiple possible etiologies have been suggested, but only aspirin (acetylsalicylic acid) has been statistically proven to be a causative factor. We describe a case of Reye syndrome secondary to influenza A virus. Read More

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http://www.ochsnerjournal.org/lookup/doi/10.31486/toj.18.009
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http://dx.doi.org/10.31486/toj.18.0098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292460PMC
January 2018
13 Reads