923 results match your criteria Pediatrics Henoch-Schonlein Purpura


Using MEST-C Scores and the International Study of Kidney Disease in Children Classification to Predict Outcomes of Henoch-Schönlein Purpura Nephritis in Children.

Front Pediatr 2021 14;9:658845. Epub 2021 Apr 14.

Department of Pediatrics, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, China.

Henoch-Schönlein purpura nephritis (HSPN) and IgA nephropathy (IgAN) bear similarities in some aspects. The histological classification of HSPN was built on the International Study of Kidney Disease in Children (ISKDC) criteria, while IgAN was established on the 2016 Oxford classification (MEST-C scores). The purpose of this paper was to discuss the predictive value of the ISKDC classification and MEST-C scores in children with HSPN. Read More

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Association of kidney biopsy findings with short- and medium-term outcomes in children with moderate-to-severe IgA vasculitis nephritis.

Eur J Pediatr 2021 May 2. Epub 2021 May 2.

Department of Multidisciplinary Pediatrics, Pediatric Nephrology Unit, Assistance Publique des Hôpitaux de Marseille, Marseille, France.

Assessing the initial severity of immunoglobulin A vasculitis nephritis (IgAV-N) is important due to its determining effect on kidney management and outcomes. This paper describes a multicentre paediatric cohort of IgAV-N patients and discusses relationships among clinical presentation, histological features, and kidney outcome. We retrospectively studied a cohort of 170 children with biopsy-proven IgAV-N, diagnosed between 2007 and 2017. Read More

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Henoch-Schönlein Purpura With Scrotal Involvement: A Case Report and Literature Review.

J Pediatr Hematol Oncol 2021 Apr 21. Epub 2021 Apr 21.

Shandong University of Traditional Chinese Medicine Department of Pediatrics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People's Republic of China.

Henoch-Schönlein purpura (HSP) is the most common vasculitis of childhood and affects the small blood vessels, leading to arthritis, abdominal pain, and renal involvement. However, scrotal involvement is a rare complication of HSP and scrotal pain. Swelling is the most frequent clinical presentation and can be easily confused with testicular torsion. Read More

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[Efficacy and safety of mycophenolate mofetil versus cyclophosphamide in the treatment of Henoch-Schönlein purpura nephritis with nephrotic-range proteinuria in children: a prospective randomized controlled trial].

Zhongguo Dang Dai Er Ke Za Zhi 2021 Apr;23(4):338-342

Department of Nephrology, Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing 100020, China.

Objective: To study the efficacy and safety of mycophenolate mofetil (MMF) versus cyclophosphamide (CTX) in the treatment of children with Henoch-Schönlein purpura nephritis (HSPN) and nephrotic-range proteinuria.

Methods: A prospective clinical trial was conducted in 68 pediatric patients who were admitted to the Department of Nephrology, Children's Hospital Affiliated to Capital Institute of Pediatrics and who were diagnosed with HSPN and nephrotic-range proteinuria from August 2016 to November 2019. The patients were randomly divided into two groups:MMF treatment (=33) and CTX treatment (=35). Read More

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IgA vasculitis with nephritis: update of pathogenesis with clinical implications.

Pediatr Nephrol 2021 Apr 5. Epub 2021 Apr 5.

Division of Pediatric Nephrology and Hypertension, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.

IgA vasculitis with nephritis (IgAVN) shares many pathogenetic features with IgA nephropathy (IgAN). The purpose of this review is to describe our current understanding of the pathogenesis of pediatric IgAVN, particularly as it relates to the four-hit hypothesis for IgAN. These individual steps, i. Read More

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Scabies, incomplete lupus erythematosus and Henoch-Schonlein purpura.

Arch Med Sci 2021 26;17(2):564-568. Epub 2021 Feb 26.

Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

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February 2021

The Use of Fecal Calprotectin Testing in Paediatric Disorders: A Position Paper of the European Society for Paediatric Gastroenterology and Nutrition Gastroenterology Committee.

J Pediatr Gastroenterol Nutr 2021 Apr;72(4):617-640

Neurogastroenterology and Motility, UCL Great Ormond Street Institute of Child Health and Department of Gastroenterology, Great Ormond Street Hospital, London, UK.

Objectives: The aim of the study was to review the evidence regarding the clinical use and value of fecal calprotectin (FC) measurements in different gastrointestinal disorders in children.

Methods: A literature search was conducted in the PubMed, MEDLINE, EMBASE, and Cochrane databases until October 31, 2019. Subtopics were identified and each assigned to individual authors. Read More

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Leukocytoclastic Vasculitis Mimicking Henoch-Schönlein Purpura Preceding Onset of Ulcerative Colitis in a Child.

Indian J Pediatr 2021 May 16;88(5):507-508. Epub 2021 Feb 16.

Department of Pediatrics, Bharati Vidyapeeth University Medical College Hospital & Research Centre, Pune, Maharashtra, 411043, India.

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HLA-DQ and HLA-DRB1 alleles associated with Henoch-Schönlein purpura nephritis in Finnish pediatric population: a genome-wide association study.

Pediatr Nephrol 2021 Feb 16. Epub 2021 Feb 16.

Department of Pediatric Nephrology and Transplantation, New Children's Hospital, University of Helsinki and Helsinki University Hospital, PO Box 347, Stenbäckinkatu 9, 00029 HUS, Helsinki, Finland.

Background: The pathophysiology of Henoch-Schönlein purpura (HSP) is still unclear, but several findings suggest that genetic factors may influence disease susceptibility. We aimed to perform a genome-wide association study (GWAS) in pediatric HSP patients with an emphasis on severe HSP nephritis.

Methods: The study included 46 HSP patients, 42 of whom had undergone kidney biopsy. Read More

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February 2021

IgA vasculitis or Henoch-Schönlein purpura: genetics and beyond.

Pediatr Nephrol 2021 Feb 16. Epub 2021 Feb 16.

Department of Paediatrics, Division of Clinical Immunology, Rheumatology and Allergology, Centre of Reference for Paediatric and Adolescent Rheumatology of Ministry of Health of the Republic Croatia, University of Zagreb School of Medicine, University Hospital Centre Zagreb, Kispaticeva 12, 10 000, Zagreb, Croatia.

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February 2021

Penile involvement of immunoglobulin a vasculitis/Henoch-Schönlein purpura.

J Pediatr Urol 2021 Jan 22. Epub 2021 Jan 22.

Department of Pediatrics, Division of Rheumatology, Hacettepe University School of Medicine, Ankara, Turkey. Electronic address:

Background: Immunoglobulin A vasculitis/Henoch-Schönlein purpura (IgAV/HSP) is a leukocytoclasia vasculitis of childhood, predominantly affecting the skin, joints, gastrointestinal tract, and kidneys. The involvement of the penis is rare.

Objective: We aimed to describe this rare manifestation of IgAV/HSP and to review the previous studies, including similar cases. Read More

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January 2021

Abnormalities of Serum Fatty Acids in Children With Henoch-Schönlein Purpura by GC-MS Analysis.

Front Pediatr 2020 21;8:560700. Epub 2021 Jan 21.

Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.

The objectives of this work were to test the levels of serum medium- and long- chain fatty acids (MLCFAs) in children and to discover their possible relationship with Henoch-Schönlein Purpura (HSP), also known as Immunoglobulin A vasculitis. A total of 57 children with HSP (HSP group) and 28 healthy children (CON group) were recruited for this study. Serum specimens were collected to detect the compositions and contents of MLCFAs by gas chromatography with mass spectrometry (GC-MS) analysis. Read More

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January 2021

MicroRNA profiling in Chinese children with Henoch-Schonlein purpura and association between selected microRNAs and inflammatory biomarkers.

Acta Paediatr 2021 Feb 3. Epub 2021 Feb 3.

Department of Pediatrics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

Aim: This study aimed to profile the microRNA levels in Chinese Henoch-Schonlein purpura (HSP) children and to explore their association with inflammatory factors and T helper 17 (Th17)/regulatory T (Treg).

Methods: Forty-five HSP children and 27 healthy controls were enrolled in this study, and microRNA levels were profiled with a microRNA microarray. The levels of selected microRNAs were determined by quantitative real-time PCR, and the levels of serum IgA, interleukin-6, interleukin-10 and interleukin-17A were detected by enzyme-linked immunosorbent assay. Read More

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February 2021

Attitude toward pediatric rheumatology among residency-trained pediatricians.

Pediatr Int 2021 Jan 29. Epub 2021 Jan 29.

Division of Rheumatology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Pediatric rheumatology (PR) is a relatively new and scarce subspecialty in emerging countries. This study aimed to investigate physicians' attitude toward and real-life clinical practice in PR among residency-trained pediatricians.

Methods: An electronic questionnaire was developed and sent via email to pediatricians that completed their residency training during 2007-2015 from Thailand. Read More

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January 2021

Infant with a rapidly progressing rash.

BMJ Case Rep 2021 Jan 25;14(1). Epub 2021 Jan 25.

Department of Pediatrics, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.

An infant presented to the emergency department with sudden onset of rapidly progressing erythematous macules and distal oedema. The rash was striking in appearance, covering most of the body, which raised concern for pressing infectious (eg, meningococcaemia) and other serious aetiologies. Nevertheless, the infant remained playful and was overall stable and posed a diagnostic and management dilemma. Read More

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January 2021

[Clinical effect and mechanism of total glucosides of paeony in the adjuvant therapy for children with Henoch-Schönlein purpura nephritis: a prospective randomized controlled study].

Zhongguo Dang Dai Er Ke Za Zhi 2021 Jan;23(1):49-54

Department of Pediatrics, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, China.

Objective: To study the clinical effect and mechanism of total glucosides of paeony (TGP) in the adjuvant therapy for children with Henoch-Schönlein purpura nephritis (HSPN).

Methods: Sixty-four HSPN children with moderate proteinuria were divided into a TGP treatment group (=34) and a routine treatment group (=30) using a random number table. Thirty healthy children who underwent physical examination were enrolled as the healthy control group. Read More

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January 2021

Clinical relevance of neutrophil-to-lymphocyte ratio and mean platelet volume in pediatric Henoch-Schonlein Purpura: a meta-analysis.

Bioengineered 2021 Dec;12(1):286-295

Department of Pediatrics, The First Hospital of Lanzhou University , Lanzhou, China.

The association of neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) with the severe gastrointestinal (GI) involvement in pediatric Henoch-Schonlein Purpura (HSP) has been reported in many studies. However, the conclusions from the previous studies were controversial. Therefore, for the first time, we performed a meta-analysis to systematically evaluate the relationship of NLR and MPV to the severe GI involvements. Read More

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December 2021

A child with Henoch-Schonlein purpura secondary to a COVID-19 infection.

BMJ Case Rep 2021 Jan 6;14(1). Epub 2021 Jan 6.

Pediatrics, Bahrain Defence Force Royal Medical Services, Riffa, Bahrain.

Henoch-Schonlein purpura (HSP) is a common IgA-mediated small vessel vasculitis of childhood that affects several systems. It is characterised by a tetrad of dermatological, abdominal, joint and renal manifestations. HSP can occur secondary to upper respiratory tract infections, medications, vaccinations and malignancies. Read More

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January 2021

Henoch-Schönlein Purpura-Associated Hemorrhagic Shock After Secondary Norovirus Infection.

Cureus 2020 Nov 23;12(11):e11653. Epub 2020 Nov 23.

Pediatrics, Children's Hospital of Philadelphia, Philadelphia, USA.

Henoch-Schönlein purpura (HSP) is a small-vessel vasculitis, typically involving the skin, joints, kidneys, and gastrointestinal (GI) tract. Although GI bleeding with HSP can occur, massive GI hemorrhage is rare. It is well documented that HSP can be triggered by a preceding infection, often of the upper respiratory tract. Read More

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November 2020

Therapeutic Potential of Carbon Monoxide (CO) and Hydrogen Sulfide (HS) in Hemolytic and Hemorrhagic Vascular Disorders-Interaction between the Heme Oxygenase and HS-Producing Systems.

Int J Mol Sci 2020 Dec 23;22(1). Epub 2020 Dec 23.

Division of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.

Over the past decades, substantial work has established that hemoglobin oxidation and heme release play a pivotal role in hemolytic/hemorrhagic disorders. Recent reports have shown that oxidized hemoglobins, globin-derived peptides, and heme trigger diverse biological responses, such as toll-like receptor 4 activation with inflammatory response, reprogramming of cellular metabolism, differentiation, stress, and even death. Here, we discuss these cellular responses with particular focus on their mechanisms that are linked to the pathological consequences of hemorrhage and hemolysis. Read More

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December 2020

Posterior lumbar subcutaneous edema as the rare sign of IgA vasculitis (Henoch-Schönlein purpura): A case of a child.

Radiol Case Rep 2021 Mar 17;16(3):438-440. Epub 2020 Dec 17.

Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kyoto, 602-8566, Japan.

Posterior lumbar subcutaneous edema (PLSE) is often found on MRI in adults with obesity or various lumbar conditions. We report a case of a 6-year-old boy with IgA vasculitis (Henoch-Schönlein purpura) along with PSLE observed on CT and MRI. The finding is markedly rare in patients with IgA vasculitis, with only limited cases previously reported in the literature. Read More

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A Bladder Mass in a Patient with Henoch-Schönlein Purpura.

J Pediatr 2021 04 13;231:289-290. Epub 2020 Dec 13.

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.

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Clinical spectrum and outcome of immunoglobulin A vasculitis in children: A 10-year clinical study.

Int J Clin Pract 2021 Apr 9;75(4):e13930. Epub 2021 Jan 9.

Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Background: Immunoglobulin A (IgA) vasculitis is the most common vasculitides of childhood. The aim of this study was to characterise the disease and identify clinical and laboratory factors associated with renal involvement.

Methods: Medical records of children aged ≤18 years with the diagnosis of IgA vasculitis according to the EULAR/PRES criteria were retrospectively reviewed for demographic data, clinical manifestations and laboratory tests. Read More

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Involvement of activated cytotoxic T lymphocytes and natural killer cells in Henoch-Schönlein purpura nephritis.

Clin Transl Immunology 2020 24;9(11):e1212. Epub 2020 Nov 24.

Department of Pediatrics Graduate School of Medical Sciences Kyushu University Fukuoka Japan.

Objectives: Immunoglobulin A vasculitis/Henoch-Schönlein purpura (IgAV/HSP) is a major cause of vasculitis in children. It is often accompanied by nephritis (HSPN) and could progress to chronic kidney disease. Galactose-deficient IgA was recently reported to be involved in the pathogenesis of HSPN, for which immunosuppressive drugs are considered key treatment. Read More

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November 2020

Influence of transitional nursing on the compliance behavior and disease knowledge of children with purpura nephritis.

World J Clin Cases 2020 Nov;8(21):5213-5220

Department of Healthcare Center, Hainan Provincial People's Hospital, Haikou 570000, Hainan Province, China.

Background: Purpura nephritis, also called Henoch-Schönlein purpura nephritis, is a systemic disease with small dead vasculitis as the main pathological change.

Aim: To observe the influence of transitional nursing activities on the compliance behaviors and disease knowledge of children with purpura nephritis.

Methods: A total of 82 children with purpura nephritis were included and divided into a general nursing group (41 children) and transitional nursing group (41 children) using the envelope method. Read More

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November 2020

Pediatric Granulomatosis With Polyangiitis Mimicking IgA Vasculitis: A Case Report.

Clin Med Insights Arthritis Musculoskelet Disord 2020 2;13:1179544120967371. Epub 2020 Nov 2.

Department of Pediatric Rheumatology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Granulomatosis with polyangiitis (GPA) is a systemic vasculitis of the upper and lower respiratory tract along with glomerulonephritis and is very rare in childhood. Its renal manifestations similarity with IgA vasculitis can be misleading.

Case Presentation: Herein, we report a 12-years-old girl with the clinical picture of IgA vasculitis and renal involvement at the time of presentation, over time, elevated cytoplasmic Anti-neutrophil Cytoplasmic Antibody (C-ANCA) and tissue biopsy confirmed GPA. Read More

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November 2020

Purpurona: A Novel Report of COVID-19-Related Henoch-Schonlein Purpura in a Child.

Pediatr Infect Dis J 2021 02;40(2):e93-e94

From the Department of Pediatrics.

The coronavirus disease 2019 global pandemic is reshaping our understanding of medicine, including the diagnostic approach to common medical presentations. We describe a novel case of a 3-year-old male with a clinical diagnosis of Henoch-Schonlein Purpura vasculitis with concurrent SARS-CoV-2 infection. This case highlights a potentially newly described presentation of coronavirus disease 2019 infection. Read More

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February 2021

From Skin to Kidneys: Cutaneous Clues of Renal Disease in Children.

Dermatol Pract Concept 2020 Oct 26;10(4):e2020095. Epub 2020 Oct 26.

Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy.

Background: The skin is often seen as a world apart, but not rarely do cutaneous manifestations reveal signs of systemic disease.

Objectives: The aim of this review is to include in one paper all the possible correlations between nephrological and dermatological manifestations of the same disease in pediatric patients while also keeping in mind that in apparent exclusively dermatological diseases there can be nephrological manifestations as part of the same disorder and vice versa.

Methods: We searched on PubMed for a possible link between skin and kidney matching the following terms and correlated MeSH terms: dermatology, skin, kidney, renal disease, nephrology, pediatrics, child, childhood, vasculitis, and cancer. Read More

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October 2020

Acute haemorrhagic oedema of infancy: a condition that is not always benign.

BMJ Case Rep 2020 Nov 2;13(11). Epub 2020 Nov 2.

Department of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', University of Messina, Messina, Sicilia, Italy

Acute haemorrhagic oedema of infancy (AHOI) is a rare condition and an unusual diagnosis for the paediatrician, as approximately 300 cases have been reported in literature so far. Although it was considered for years a less serious variant of Henoch-Schönlein purpura, nowadays it is thought to be a different entity, with his own characteristics and clinical outcome. In literature it is described as a benign condition, self-limiting and without any systemic involvement in most of the cases. Read More

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November 2020

A delayed diagnosis of late-onset pulmonary hemorrhage in a toddler with Henoch-Schönlein purpura after regression of skin rash: A case report and literature review.

Medicine (Baltimore) 2020 Oct;99(44):e23025

Department of Pediatrics.

Rationale: Pulmonary hemorrhage is a rare but fatal complication of Henoch-Schönlein purpura (HSP), and more easily ignored in children than in adults due to the absence of clinically evident hemoptysis. Moreover, despite being sporadically reported, given that pulmonary hemorrhage may develop after regression and even disappearance of skin rash, the asynchronous progression of skin and lung lesions poses escalating challenges in the timely diagnosis. We herein presented a delayed diagnosis of late-onset pulmonary hemorrhage in a child with HSP after regression of purpuric rash. Read More

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October 2020