873 results match your criteria Pediatrics Henoch-Schonlein Purpura


Recurrent Henoch-Schönlein Purpura with bullous rash and pulmonary nodules.

Pediatr Rheumatol Online J 2020 May 24;18(1):40. Epub 2020 May 24.

Department of Pediatrics, Duke University Hospital, 2301 Erwin Rd, Durham, NC, 27705, USA.

Background: Henoch-Schönlein purpura (HSP) is the most common vasculitis of childhood. It has a characteristic rash described as palpable purpura that most frequently affects the distal lower extremities and buttocks. HSP rarely presents with bullous rash nor pulmonary nodules. Read More

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http://dx.doi.org/10.1186/s12969-020-00436-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245848PMC

Erythema multiforme in a 14-year-old girl with Henoch-Schönlein purpura and pancolitis: a relationship with mesalazine?

J Dtsch Dermatol Ges 2020 May;18(5):496-498

Institute of Dermatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

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http://dx.doi.org/10.1111/ddg.14089DOI Listing

Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch-Schönlein purpura nephritis.

Pediatr Res 2020 May 14. Epub 2020 May 14.

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

Background: To evaluate the apoptosis inhibitor of macrophage (AIM) deposition patterns on the kidneys of children with IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephritis (HSPN) and to investigate the clinical usefulness of serum and/or urinary AIM levels as biomarkers for the disease activity.

Methods: Immunohistochemical study was performed in the kidneys of 37 patients with IgAN and 10 patients with HSPN. Serum and urinary AIM levels in the patients and 20 healthy controls (HCs) were quantified by enzyme-linked immunosorbent assay. Read More

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http://dx.doi.org/10.1038/s41390-020-0951-1DOI Listing

Activation of Complement System in Henoch-Schönlein Purpura Nephritis.

Fetal Pediatr Pathol 2020 May 13:1-8. Epub 2020 May 13.

Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

We studied the association between Henoch-Schönlein purpura nephritis (HSPN) and complement system activation. We retrospectively reviewed the pathologic findings and medical records of 35 children and 12 adults with HSPN and compared the differences according to C4d positivity in three groups consisting of total 47 patients, 35 pediatric and 12 adult patients, respectively. C4d staining of renal biopsy was additionally performed at the time of diagnosis or retrospectively using archival biopsy material. Read More

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http://dx.doi.org/10.1080/15513815.2020.1761914DOI Listing
May 2020
0.398 Impact Factor

Henoch-Schönlein Purpura in Children: An Updated Review.

Curr Pediatr Rev 2020 May 7. Epub 2020 May 7.

Pediatric Institute, Kuala Lumpur General Hospital, Kuala Lumpur. Malaysia.

Background: Henoch-Schönlein purpura (HSP) is an IgA-mediated systemic small-vessel vasculitis with a predilection for the skin, gastrointestinal tract, joints, and kidneys. It is the most common form of systemic vasculitis in children.

Objective: To familiarize physicians with the etiopathogenesis, etiology, clinical manifestations, evaluation, and management of children with Henoch-Schönlein purpura. Read More

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http://dx.doi.org/10.2174/1573396316666200508104708DOI Listing

IgA vasculitis with nephritis in children.

Adv Clin Exp Med 2020 Apr;29(4):513-519

Chair and Department of Pediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Poland.

Immunoglobulin A vasculitis (IgAV), formerly known as Henoch-Schönlein purpura (HSP), is the most common form of systemic vasculitis in children. Although the first case of IgAV was described more than 200 years ago, its etiology still remains unclear. Nephrological symptoms are observed in 30-50% of children during the course of the disease, and in up to 91% of cases within 6 weeks of the onset of the first symptoms. Read More

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http://dx.doi.org/10.17219/acem/112566DOI Listing

Childhood vasculitis.

Authors:
Seza Ozen Erdal Sag

Rheumatology (Oxford) 2020 May;59(Supplement_3):iii95-iii100

Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey.

Vasculitis is a challenging disease for paediatricians. Certain vasculitides are quite common in children whereas others are much rarer compared with adults. The most common vasculitides in childhood are IgA-associated vasculitis (Henoch-Schönlein purpura) and Kawasaki disease, which are usually self-limiting vasculitides although children do develop complications as a result. Read More

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http://dx.doi.org/10.1093/rheumatology/kez599DOI Listing
May 2020
4.475 Impact Factor

Intramuscular Hematoma as a Manifestation of IgA Vasculitis.

Pediatrics 2020 May 14;145(5). Epub 2020 Apr 14.

Eastern Virginia Medical School and Children's Hospital of The King's Daughters, Norfolk, Virginia.

We describe an atypical pediatric case of immunoglobulin A vasculitis (IgAV), also referred to as Henoch-Schönlein purpura, in which formation of spontaneous hematoma of the paraspinal muscles developed. Spontaneous or unprovoked hematomas rarely occur in IgAV. These manifestations have not been described specifically in the pediatric literature as coinciding with IgAV. Read More

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http://dx.doi.org/10.1542/peds.2019-1668DOI Listing

Henoch-Schönlein Purpura Presenting in Association With Neuroblastoma: A Case Report.

Front Pediatr 2020 28;8:77. Epub 2020 Feb 28.

Division of Pediatric Rheumatology, University of Minnesota, Minneapolis, MN, United States.

Henoch-Schönlein purpura (HSP) is a common systemic vasculitis affecting children. It is managed in the outpatient setting and rarely associated with malignancy. We present a case of neuroblastoma in a 7-year-old boy diagnosed after suspected HSP. Read More

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http://dx.doi.org/10.3389/fped.2020.00077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093007PMC
February 2020

Predictive role of neutrophil to lymphocyte ratio and mean platelet volume in Henoch-Schönlein purpura related gastrointestinal and renal involvement.

Arch Argent Pediatr 2020 Apr;118(2):139-142

Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.

Background: Henoch-Schönlein purpura (HSP) is a systemic small-vessel vasculitis that occurs mainly in children. The aim was to evaluate the blood neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) in patients with HSP and to investigate the relationship with gastrointestinal and renal involvement.

Methods: Children with HSP and healthy individuals as controls were included. Read More

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http://dx.doi.org/10.5546/aap.2020.eng.139DOI Listing

Urinary proteomics of Henoch-Schönlein purpura nephritis in children using liquid chromatography-tandem mass spectrometry.

Clin Proteomics 2020 12;17:10. Epub 2020 Mar 12.

1Department of Pediatrics, Jinling Hospital, the First School of Clinical Medicine, Southern Medical University, No. 305 Zhongshan East Road, Nanjing, 210002 Jiangsu China.

Background: Henoch-Schönlein purpura nephritis (HSPN) is the principal cause of morbidity and mortality in children with Henoch-Schönlein purpura (HSP). However, the criteria for risk assessment currently used is not satisfactory. The urine proteome may provide important clues to indicate the development of HSPN. Read More

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http://dx.doi.org/10.1186/s12014-020-09274-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066733PMC

Clinical outcome in pediatric refractory gastrointestinal Henoch-Schönlein purpura treated with mycophenolate mofetil.

Eur J Pediatr 2020 Mar 6. Epub 2020 Mar 6.

Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, People's Republic of China.

The aim of the present study was to investigate the clinical outcome of mycophenolate mofetil in pediatric refractory gastrointestinal (GI) Henoch-Schönlein purpura (HSP). Most of the HSP patients with GI symptoms may benefit from early introduction of glucocorticoid; however, a number of patients still do not achieve remission following the administration of steroids. Therefore, the present study was to investigate the clinical features and the clinical outcome of mycophenolate mofetil in refractory GI HSP. Read More

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http://dx.doi.org/10.1007/s00431-020-03592-wDOI Listing

Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia.

BMC Nephrol 2020 Feb 26;21(1):65. Epub 2020 Feb 26.

Department of Pediatrics, University Hospital Centre Split, 21000, Split, Croatia.

Background: Information about renal diseases in children is available from national registries of renal biopsies. Aim of the study was to compare the clinical presentation of glomerular diseases and tubulointerstitial space diseases with pathohistological diagnosis of indicated renal biopsies from pediatric population in the Croatian region of Dalmatia.

Methods: Out of 231 pediatric patients with suspected glomerular and tubulointerstitial diseases, 54 underwent ultrasound-guided renal biopsy at University Hospital of Split. Read More

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http://dx.doi.org/10.1186/s12882-020-01727-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045640PMC
February 2020

Serosal surface small vessel vasculitis in Henoch-Schonlein purpura.

Pediatr Neonatol 2020 Jan 25. Epub 2020 Jan 25.

Island Hospital, Macalister Road, George Town, 10450, Penang, Malaysia.

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http://dx.doi.org/10.1016/j.pedneo.2020.01.002DOI Listing
January 2020

Beneficial Effects of Qingzixiaoban Granule on Henoch-Schönlein Purpura Nephritis Mice through Inhibiting Immune Complex Deposition and Th2 Immunodeviation.

Evid Based Complement Alternat Med 2019 16;2019:3050248. Epub 2019 Oct 16.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: Henoch-Schönlein purpura nephritis (HSPN) is the principal cause of morbidity and mortality in Henoch-Schönlein purpura (HSP). However, there is no absolute consensus for the best management of severe HSPN till now. Qingzixiaoban Granule (QZXB GR), a traditional Chinese medicine formula, has been applied to treat HSP in clinical in China. Read More

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http://dx.doi.org/10.1155/2019/3050248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817923PMC
October 2019

Treatment of refractory IgA vasculitis with dapsone: a systematic review.

Clin Exp Pediatr 2020 May 24;63(5):158-163. Epub 2019 Sep 24.

Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.

IgA vasculitis, formerly known as Henoch-Schönlein purpura, is a systemic IgA-mediated vasculitis of the small vessels commonly seen in children. The natural history of IgA vasculitis is generally self-limiting; however, one-third of patients experience symptom recurrence and a refractory course. This systematic review examined the use of dapsone in refractory IgA vasculitis cases. Read More

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http://dx.doi.org/10.3345/kjp.2019.00514DOI Listing

Preventive Effect of Tonsillectomy on Recurrence of Henoch-Schönlein Purpura Nephritis after Intravenous Methylprednisolone Pulse Therapy.

Tohoku J Exp Med 2020 01;250(1):61-69

Department of Pediatrics, The Jikei University School of Medicine.

Henoch-Schönlein purpura (HSP) is regarded as a benign and self-limiting vasculitis characterized by purpura, arthritis, and gastrointestinal symptoms; however, about one third of the patients develop HSP nephritis (HSPN), the most serious long-term complication. Since 2013, we have proposed that tonsillectomy in addition to intravenous methylprednisolone pulse therapy (IVMP) be performed in all patients with HSPN, similar to immunoglobulin A nephropathy (IgAN) patients because both diseases are considered to a share common pathogenesis. Herein, we retrospectively reviewed the clinical courses of 71 Japanese children with HSPN (34 boys; median age at diagnosis, 6. Read More

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http://dx.doi.org/10.1620/tjem.250.61DOI Listing
January 2020

Henoch-Schonlein purpura in pediatrics: Ten years of experience at a moderate risk office of a general hospital.

Arch Argent Pediatr 2020 02;118(1):31-37

Moderate Risk Office, Department of Pediatrics. Hospital Nacional "Profesor Dr. Alejandro Posadas," Department of Pediatrics.

Introduction: Henoch-Schonlein purpura (HSP) is the most common small vessel leukocytoclastic vasculitis during childhood. It is characterized by palpable purpura and/or joint, abdominal or renal involvement.

Objective: To describe the epidemiological, clinical, laboratory, and evolutionary characteristics of patients with HSP. Read More

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http://dx.doi.org/10.5546/aap.2020.eng.31DOI Listing
February 2020

Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura) - a dramatic presentation for a benign disease.

F1000Res 2019 17;8:1771. Epub 2019 Oct 17.

Department of Pediatrics, Pugliese Ciaccio Hospital, Catanzaro, Italy.

We present a case of an 11-month-old girl who was referred to our unit for an erythematous rash that appeared on the face and extremities. Personal and family history was not relevant. Laboratory tests were normal. Read More

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http://dx.doi.org/10.12688/f1000research.20645.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944248PMC

Hemotologic Indices for Predicting Internal Organ Involvement in Henoch-Schönlein Purpura (IgA vasculitis).

J Pediatr Hematol Oncol 2020 Jan;42(1):e46-e49

Division of Pediatric Hematology/Oncology.

Henoch-Schönlein purpura is the most common vasculitis of childhood. This study investigated the values of hematologic indices that can help predict internal organ involvement. The study included 112 patients followed up between January 2007 and May 2017 and 81 healthy children. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001571DOI Listing
January 2020

Correlation of urine protein/creatinine ratios to 24-h urinary protein for quantitating proteinuria in children.

Pediatr Nephrol 2020 03 7;35(3):463-468. Epub 2019 Dec 7.

Department of Anesthesia, Stanford University School of Medicine, Palo Alto Veterans Institute for Research, Stanford, CA, USA.

Background: The purpose of this study was to evaluate the correlation and consistency between urine protein/creatinine ratio (UPCR) and 24-h urine protein (24HUPr) in children, and to determine cutoff values of UPCR relative to 24HUPr at 100 mg/m/d (≥ 100 mg/m/d as pathological proteinuria) and 1000 mg/m/d (≥ 1000 mg/m/d as nephrotic-range proteinuria).

Methods: Three hundred sixty-six children were enrolled, including 81 controls, 109 with Henoch-Schönlein purpura nephritis, 167 with nephrotic syndrome, 5 with IgA nephropathy, and 4 with lupus nephritis. Patients were divided into three groups: normal group; non-nephrotic-range proteinuria group; nephrotic-range proteinuria group. Read More

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http://dx.doi.org/10.1007/s00467-019-04405-5DOI Listing

Immune deposits in skin vessels of patients with acute hemorrhagic edema of young children: A systematic literature review.

Pediatr Dermatol 2020 Jan 22;37(1):120-123. Epub 2019 Nov 22.

Pediatric Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona, Switzerland.

Background: Acute hemorrhagic edema of young children is a benign skin-limited vasculitis mainly affecting children 2 to 24 months of age, which is often considered the infantile variant of immunoglobulin A vasculitis (Henoch-Schönlein purpura). In most cases, the diagnosis is made on a clinical basis without a skin biopsy.

Methods: A systematic review of the literature was performed to examine the reported prevalence of vascular immune deposits in skin biopsies of patients with acute hemorrhagic edema of young children. Read More

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http://dx.doi.org/10.1111/pde.14041DOI Listing
January 2020

Obesity is associated with Henoch-Schönlein Purpura Nephritis and development of end-stage renal disease in children.

Ren Fail 2019 Nov;41(1):1016-1020

Department of Pediatrics, Fujian Provincial Hospital, Fujian Medical University Shengli Clinical Medical College, Fuzhou, China.

To explore the association of obesity with the occurrence of Henoch-Schönlein Purpura Nephritis (HSPN) and development of end-stage renal disease (ESRD) in children with Henoch-Schönlein Purpura (HSP). This was a retrospective study of 446 pediatric patients with diagnosed HSP. All patients' demographic characteristics, clinical features, and laboratory data were collected from the electronic medical records in hospitals from January 2008 to December 2014, and the prognosis was followed up till December 2018. Read More

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http://dx.doi.org/10.1080/0886022X.2019.1685545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882475PMC
November 2019

Predictive role of laboratory markers and clinical features for recurrent Henoch-Schönlein Purpura in childhood: A study from Turkey.

Mod Rheumatol 2020 Feb 3:1-6. Epub 2020 Feb 3.

Ege University Faculty of Medicine, Department of Pediatrics, General Pediatrics Unit, Ege University, Bornova, Turkey.

Henoch Schönlein Purpura is the most common systemic vasculitis of the childhood. The objective of this study was to evaluate whether there is a clinical significance of laboratory parameters and clinical features on the prediction of the recurrent Henoch Schönlein Purpura in children. For recurrent Henoch Schönlein Purpura, several laboratory results and clinical features were examined to identify the predictor factors via the logistic regression model in 99 children with Henoch Schönlein Purpura. Read More

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http://dx.doi.org/10.1080/14397595.2019.1690966DOI Listing
February 2020

Changes of inflammatory mediators and oxidative stress indicators in children with Henoch-Schönlein purpura and clinical effects of hemoperfusion in the treatment of severe Henoch-Schönlein purpura with gastrointestinal involvement in children.

BMC Pediatr 2019 11 4;19(1):409. Epub 2019 Nov 4.

Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.

Background: To explore the changes of inflammatory and oxidative stress responses in Henoch-Schönlein purpura (HSP) children, and further analyzed the therapeutic effects and mechanisms of hemoperfusion (HP) on HSP with severe gastrointestinal (GI) involvement.

Methods: There were 200 children with HSP were divided into three groups according to their clinical manifestations: 60 in HSP without GI and renal involvement group, 60 in HSP with GI involvement group, and 80 in HSPN group. The HSP with GI involvement group was subdivided into conventional treatment (n = 30) and HP (n = 30) groups. Read More

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http://dx.doi.org/10.1186/s12887-019-1802-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827241PMC
November 2019

[Clinical effect of double filtration plasmapheresis combined with glucocorticoid and immunosuppressant in treatment of children with severe Henoch-Schönlein purpura nephritis].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Oct;21(10):955-959

Department of Pediatrics, Harrison International Peace Hospital, Hengshui, Hebei 053000, China.

Objective: To study the clinical effect and safety of double filtration plasmapheresis (DFPP) combined with double pulse therapy with methylprednisolone (MP) and cyclophosphamide (CTX) in the treatment of children with severe Henoch-Schönlein purpura nephritis (HSPN).

Methods: A total of 60 children with severe HSPN who were admitted to the hospital from January 2014 to March 2018 were enrolled and were randomly divided into an observation group and a control group (n=30 each). In addition to routine treatment, the children in the control group were given MP+CTX pulse therapy. Read More

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October 2019
7 Reads

Unusual presentation of Henoch-Schönlein purpura.

J Biol Regul Homeost Agents 2019 Sep-Oct;33(5 Suppl. 1):69-74

Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Unit of Emergency Pediatrics, University of Messina, Policlinico "G. Martino" Messina, Italy.

Henoch Schonlein Purpura (HSP) is a systematic IgA-mediated vasculitic disease that affects the small vessels of the skin, the joints, the gastrointestinal tract and the kidneys (1). It is the most common childhood vaculitis, with an incidence estimated at 3-26 per 100,000 children, and with a male-to-female ratio of 2:1 (2-6). The 90% of patients are under 10 years of age, with a mean age of 4 years (4). Read More

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November 2019
2 Reads

Dapsone in immunoglobulin A-associated vasculitis.

Eur J Pediatr 2019 12 19;178(12):1913-1914. Epub 2019 Oct 19.

Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.1007/s00431-019-03472-yDOI Listing
December 2019

Henoch-Schönlein Purpura Nephritis and Cerebral Venous Sinus Thrombosis Due to Hereditary Deficiency of Antithrombin III.

Indian J Pediatr 2020 02 17;87(2):163-164. Epub 2019 Oct 17.

Department of Pediatrics, Jinling Hospital, Southern Medical University, Nanjing, China.

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http://link.springer.com/10.1007/s12098-019-03081-5
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http://dx.doi.org/10.1007/s12098-019-03081-5DOI Listing
February 2020
2 Reads

National Trends in the Epidemiology and Resource Use for Henoch-Schönlein Purpura (IgA Vasculitis) Hospitalizations in the United States From 2006 to 2014.

Hosp Pediatr 2019 11 1;9(11):888-896. Epub 2019 Oct 1.

Section of Neonatology, Valley Children's Healthcare, Madera, California

Objectives: We examined the trends in the rate of Henoch-Schönlein purpura (HSP) hospitalizations and the associated resource use among children in the United States from 2006 through 2014.

Methods: Pediatric hospitalizations with HSP were identified by using , code 287.0 from the National Inpatient Sample. Read More

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http://dx.doi.org/10.1542/hpeds.2019-0131DOI Listing
November 2019

Risk factors associated with IgA vasculitis with nephritis (Henoch-Schönlein purpura nephritis) progressing to unfavorable outcomes: A meta-analysis.

PLoS One 2019 1;14(10):e0223218. Epub 2019 Oct 1.

Department of Nephrology, Children's Hospital, Chongqing Medical University, Chongqing, China.

Objective: To identify risk factors associated with unfavorable outcomes in children with IgA vasculitis with nephritis (Henoch-Schőnlein purpura nephritis)(IgA-VN).

Methods: PubMed, Embase, and Web of Science databases were searched for studies, published in English through February 2019. The data were extracted to perform pooled analysis, heterogeneity testing, subgroup analysis, sensitivity analysis, and publication bias analysis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223218PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772070PMC
March 2020
4 Reads

Early recognition and treatment of Henoch-Schönlein purpura in children.

Authors:
Ann Wilkinson

Nurs Child Young People 2019 Sep;31(5):36-40

Gresleydale Healthcare Centre, Derbyshire, England.

Henoch-Schönlein purpura (HSP) is characterised by a non-blanching rash, which commonly affects the lower limbs of children aged 3-15 years. It is the most common vasculitis in children. HSP often develops after an upper respiratory tract infection and is more likely to present in autumn, winter and spring. Read More

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http://dx.doi.org/10.7748/ncyp.2019.e1118DOI Listing
September 2019
2 Reads

Serum levels of selected cytokines [interleukin (IL)-17A, IL-18, IL-23] and chemokines (RANTES, IP10) in the acute phase of immunoglobulin A vasculitis in children.

Rheumatol Int 2019 Nov 29;39(11):1945-1953. Epub 2019 Aug 29.

Department of Paediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, ul. 3-go Maja 13-15, 41-800, Zabrze, Poland.

The pathogenesis of the immunoglobulin A vasculitis (IgAV) is still unknown. The available data shows that interleukin (IL)-17, IL-18, IL-23, regulated on activation, normal T cell expressed and secreted (CCL 5, RANTES), and interferon (IFN)-γ-inducible protein 10 (IP10) participate in the pathogenesis of IgAV by influencing the recruitment of leukocytes to the site of inflammation. The aim of this study was to analyze the serum concentration of IL-17A, IL-18, IL-23, RANTES, and IP10 in patients with acute IgAV compared to healthy children. Read More

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http://dx.doi.org/10.1007/s00296-019-04415-4DOI Listing
November 2019
3 Reads

Rituximab-induced Henoch-Schonlein purpura in a patient with mantle cell lymphoma.

J Allergy Clin Immunol Pract 2020 Feb 10;8(2):783-785.e1. Epub 2019 Aug 10.

Division of Allergy and Immunology, Department of Internal Medicine, Washington University School of Medicine in St Louis, St Louis, Mo. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2019.07.041DOI Listing
February 2020
5 Reads

Does MEST-C score predict outcomes in pediatric Henoch-Schönlein purpura nephritis?

Pediatr Nephrol 2019 12 11;34(12):2583-2589. Epub 2019 Aug 11.

Section of Nephrology, Department of Pediatrics, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Background: Children with Henoch-Schönlein purpura nephritis (HSPN) have an increased risk of chronic kidney disease (CKD). Renal biopsy diagnostic of HSPN is graded using the International Study of Kidney Disease in Children criteria, which do not predict outcomes. The 2016 Oxford Classification's MEST-C scoring system predicts outcomes in adults with histologically identical IgA nephropathy, but evidence of its utility in pediatric HSPN is lacking. Read More

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http://dx.doi.org/10.1007/s00467-019-04327-2DOI Listing
December 2019
7 Reads

Lupus anticoagulant-hypoprothrombinemia syndrome and immunoglobulin-A vasculitis: a report of Japanese sibling cases and review of the literature.

Rheumatol Int 2019 Oct 7;39(10):1811-1819. Epub 2019 Aug 7.

Department of Pediatric Hematology/Oncology, Okayama University Hospital, 2-5-1, Shikatacho, Kitaku, Okayama, 700-8558, Japan.

Lupus anticoagulant-hypoprothrombinemia syndrome (LAHPS) is a rare bleeding disorder caused by antiprothrombin antibodies. LAHPS is associated with systemic lupus erythematosus (SLE) or infections. We describe two Japanese brothers with immunoglobulin-A vasculitis (IgAV) who met the diagnostic criteria of LAHPS. Read More

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http://dx.doi.org/10.1007/s00296-019-04404-7DOI Listing
October 2019
3 Reads

Role of p300 in the pathogenesis of Henoch-Schonlein purpura nephritis and as a new target of glucocorticoid therapy in mice.

Chin Med J (Engl) 2019 Aug;132(16):1942-1950

Department of Pediatrics, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China.

Background: Henoch-Schonlein purpura nephritis (HSPN) is a very common secondary kidney disease of childhood. Its pathogenesis and the treatment mechanism of glucocorticoid have not been fully elucidated. The aim of this study was to determine the relationship between p300 and the pathogenesis, glucocorticoid therapy in mice with HSPN, respectively. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708694PMC
August 2019
3 Reads
1.016 Impact Factor

50 Years Ago in TheJournal ofPediatrics: Anaphylactoid Purpura: Streptococcal Antibody Titers and β-Globulin Levels.

Authors:
Philip J Hashkes

J Pediatr 2019 Aug;211:111

Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1016/j.jpeds.2019.01.029DOI Listing
August 2019
2 Reads

Hemotological Indices for Predicting Internal Organ Involvement in Henoch-Schönlein Purpura (IgA vasculitis).

J Pediatr Hematol Oncol 2019 Jul 23. Epub 2019 Jul 23.

Division of Pediatric Hematology/Oncology.

Henoch-Schönlein purpura is the most common vasculitis of childhood. This study investigated the values of hematological indices that can help predict internal organ involvement. The study included 112 patients followed up between January 2007 and May 2017 and 81 healthy children. Read More

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http://Insights.ovid.com/crossref?an=00043426-900000000-9750
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http://dx.doi.org/10.1097/MPH.0000000000001571DOI Listing
July 2019
3 Reads

Association of the infectious triggers with childhood Henoch-Schonlein purpura in Anhui province, China.

J Infect Public Health 2020 Jan 20;13(1):110-117. Epub 2019 Jul 20.

Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, China. Electronic address:

Background: Although the specific etiology of Henoch-Schonlein purpura (HSP) is still unknown, several kinds of infectious triggers have been proved to participate in its pathogenesis. The objectives of present study were to analyze the association of the infectious triggers with childhood HSP in Anhui province, China.

Methods: 1200 HSP children were recruited from January 2015 to December 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18760341193023
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http://dx.doi.org/10.1016/j.jiph.2019.07.004DOI Listing
January 2020
8 Reads

Inflammasomes and autoimmune and rheumatic diseases: A comprehensive review.

J Autoimmun 2019 09 17;103:102299. Epub 2019 Jul 17.

Department of Internal Medicine IV, Medical University Innsbruck, Innsbruck, Austria.

Inflammasomes are a multi-protein platform forming a part of the innate immune system. Inflammasomes are at standby status and can be activated when needed. Inflammasome activation is an important mechanism for the production of active interleukin (IL)-1β and IL-18, which have important roles to instruct adaptive immunity. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.06.010DOI Listing
September 2019
8 Reads
8.410 Impact Factor

[Analysis of relevant risk factors to Henoch-Schönlein purpura in Tibetan children].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Jun;31(6):742-745

Department of Pediatric Intensive Care Unit, Anhui Provincial Children's Hospital, Hefei 230051, Anhui, China. Xu Yuanyuan is working on the Department of Pediatrics, Shannan People's Hospital of Tibet Autonomous Region, Shannan 856000, Tibet Autonomous Region, China. Corresponding author: Xu Yuanyuan, Email:

Objective: To analyze probable risk factors to Henoch-Schönlein purpura (HSP) in Tibetan children so as to bring evidences for correct identification of high-risk children in plateau areas.

Methods: 140 high-altitude Tibetan children with HSP admitted to Shannan People's Hospital of Tibet Autonomous Region from October 2015 to October 2018 were enrolled, and 140 high-altitude Tibetan healthy children and 140 plain area HSP children were selected as the control. Gender, age, family history, allergy, past history (rheumatic disease, autoimmune disease, asthma), clinical phenotype, biochemical markers (antibody positive rate, platelet count and hemoglobin), clinical efficacy and recurrence were retrospective analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.06.016DOI Listing
June 2019
8 Reads

Functional Immunoregulation by Heme Oxygenase 1 in Juvenile Autoimmune Diseases.

Curr Gene Ther 2019 ;19(2):110-116

Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, 410013, China.

An autoimmune disease is an inflammatory condition in which the human body's immune system attacks normal cells, resulting in decreased and abnormal immune function, which eventually leads to tissue damage or organ dysfunction. In the field of medicine, especially in pediatrics, knowledge about autoimmune diseases is still inadequate. Some common juvenile autoimmune diseases such as Henoch-Schonlein purpura, systemic juvenile idiopathic arthritis, mucocutaneous lymph node syndrome, and autoimmune encephalitis cause considerable public concern. Read More

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http://dx.doi.org/10.2174/1566523219666190710092935DOI Listing
January 2019
13 Reads

Indications and efficiency of dapsone in IgA vasculitis (Henoch-Schonlein purpura): case series and a review of the literature.

Eur J Pediatr 2019 Aug 22;178(8):1275-1281. Epub 2019 Jun 22.

Department of Pediatrics, Hôpital Civil Marie Curie, CHU of Charleroi, 140 Chaussée de Bruxelles, 6042, Charleroi (Lodelinsart), Belgium.

Immunoglobulin A (IgA) vasculitis (Henoch-Schonlein purpura (HSP)) is the most common vasculitis in children. It is characterized by purpuric rash, arthritis, gastrointestinal, and/or renal involvement. Spontaneous resolution is the typical outcome. Read More

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http://dx.doi.org/10.1007/s00431-019-03409-5DOI Listing
August 2019
17 Reads

Changes in clinical features in Henoch-Schönlein purpura during three decades: an observational study at a single hospital in Korea.

Clin Rheumatol 2019 Oct 8;38(10):2811-2818. Epub 2019 Jun 8.

Departments of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Objective: It is unknown whether epidemiological or clinical characteristics of Henoch-Schönlein purpura (HSP) have changed over time. This study aimed at evaluating the epidemiological and clinical changes of HSP during 3 decades.

Methods: We retrospectively analyzed the data of 515 children with HSP (0-15 years of age) between 1987 and 2015. Read More

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http://dx.doi.org/10.1007/s10067-019-04628-9DOI Listing
October 2019
8 Reads

A case of acute encephalophathy with residual neurological sequelae induced by immunoglobulin A vasculitis.

J Clin Neurosci 2019 Sep 11;67:270-271. Epub 2019 Jun 11.

Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.

Immunoglobulin A vasculitis (IgAV) occasionally induces central nervous system (CNS) involvement, which is usually transient with no sequelae except for hemorrhagic stroke. It is thought to be useful to measure serum and cerebrospinal fluid (CSF) cytokine levels for better understanding the pathological condition in encephalopathy, but there have been no reports in acute encephalopathy with IgAV. We describe an 8-year-old boy with IgAV who had neurological sequelae after complication of acute encephalopathy, focusing on the cytokine profiles and unique biphasic findings of magnetic resonance imaging. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.05.061DOI Listing
September 2019
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A Presumed Etiology of Kawasaki Disease Based on Epidemiological Comparison With Infectious or Immune-Mediated Diseases.

Front Pediatr 2019 21;7:202. Epub 2019 May 21.

Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Kawasaki disease (KD) may be associated with infection of unknown pathogen(s). For predicting of the etiology of KD, we evaluated epidemiological characteristics in KD, common infectious diseases and immune-mediated diseases in childhood. We respectively, reviewed the data of patients with KD, influenza, aseptic meningitis, exanthem subitum (ES), (MP) pneumonia, acute pyelonephritis (APN), Henoch-Schönlein purpura (HSP), acute poststreptococcal glomerulonephritis (APSGN), and childhood asthma. Read More

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http://dx.doi.org/10.3389/fped.2019.00202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536658PMC
May 2019
27 Reads

RhACE2 - playing an important role in inhibiting apoptosis induced by Ang II in HUVECs.

Medicine (Baltimore) 2019 May;98(22):e15799

Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Background: Henoch-Schonlein purpura (HSP) is a common hemorrhagic disease, which manifests the inflammation in the body's most microvasculars. Angiotensin II (Ang II) can induce the damage and apoptosis of vascular endothelial cells while angiotensin converting enzyme 2 (ACE2) can antagonist the action of Ang II. However, the effect of ACE2 on Ang II-induced endothelial damage remains unknown. Read More

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http://dx.doi.org/10.1097/MD.0000000000015799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708613PMC
May 2019
22 Reads

Efficacy and Safety of Chinese Herbs for the Prevention of the Risk of Renal Damage in Henoch-Schonlein Purpura in Children: Meta-Analysis of Randomized Controlled Trials and GRADE Evaluation.

Evid Based Complement Alternat Med 2019 18;2019:4089184. Epub 2019 Apr 18.

Department of Pediatrics, First Affiliated Hospital, Henan University of Chinese Medicine, Zhengzhou, Henan 450000, China.

To evaluate the efficacy and safety of traditional Chinese medicine in preventing kidney damage caused by Henoch-Schonlein Purpura (HSP) in Children by meta-analysis. We systematically searched the main Chinese and English electronic databases and collected randomized controlled trials of Chinese herbs in children with HSP until July 2018. Then we used the bias risk assessment tool in Cochrane Handbook 5. Read More

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http://dx.doi.org/10.1155/2019/4089184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500638PMC
April 2019
5 Reads