1,050 results match your criteria Pediatrics Henoch-Schonlein Purpura

Age Related Characteristics Of Children And Adolescent With Henoch Schönlein Purpura And Systems Involvement: An Experience From Tertiary Care Center.

J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):336-340

Department of Paediatrics Aga Khan University Hospital Karachi, Pakistan.

Background: Henoch-Schönlein Purpura (HSP) is the most common vasculitis among children and adolescent characterized by skin, joints, renal and gastrointestinal involvement. There is different presenting feature of Henoch-Schönlein Purpura (HSP) and systemic involvement may vary at a certain age group.

Methods: This was a ten-year retrospective cohort study done at a tertiary care hospital of Pakistan conducted from 2011-2020. Read More

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Serum immunoglobulin profiles in Chinese children with Henoch-Schönlein purpura.

Scand J Immunol 2022 May 10:e13191. Epub 2022 May 10.

Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.

The present study focuses on the associations of serum immunoglobulin with disease activity, relapse/recurrence and renal involvement in Henoch-Schönlein purpura (HSP) children. 1683 Chinese children with HSP were recruited from January 2015 to January 2021. Laboratory data of blood samples and urine tests were collected. Read More

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A 16-Year-Old-Girl With Asthma, Palpable Purpura, and Hypereosinophilia.

Chest 2022 May;161(5):e305-e308

Department of Pediatrics, Government Medical College and Hospital, Chandigarh, India.

Case Presentation: A 16-year-old girl presented to the ED with complaints of loose stools, abdominal pain, and rash over her legs for the last 7 days. There was no history of fever, vomiting, oral ulcers, or mucosal bleeds. In the past, she had received a diagnosis of asthma. Read More

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Efficacy and Safety of Tacrolimus in the Treatment of Pediatric Henoch-Schönlein Purpura Nephritis.

Paediatr Drugs 2022 May 5. Epub 2022 May 5.

Department of Pediatric Nephrology, Lanzhou University Second Hospital, Lanzhou, Gansu, 730030, China.

Background: Children with severe Henoch-Schönlein purpura nephritis (HSPN) may progress to end-stage renal disease without appropriate treatment.

Objective: This study aimed to investigate the efficacy and safety of tacrolimus combined with glucocorticoids in the treatment of pediatric HSPN.

Methods: A total of 87 HSPN patients with urinary protein ≥ 0. Read More

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Additional Refinement of CKD Prognostication Using Lymphatic Vessel Density: IgA Nephropathy as the Role Model?

Kidney Int Rep 2022 Apr 10;7(4):667-670. Epub 2022 Jan 10.

Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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An Evaluation of Choroidal and Retinal Nerve Fiber Layer Thicknesses Using SD-OCT in Children with Childhood IgA Vasculitis.

Diagnostics (Basel) 2022 Apr 5;12(4). Epub 2022 Apr 5.

Department of Pediatrics, School of Medicine, Adıyaman University, Adiyaman 02000, Turkey.

Background: We aimed to evaluate choroidal and retinal nerve fiber layer (RNFL) thicknesses in children undergoing the childhood IgA vasculitis (IgAV).

Methods: Fifty-two patients with IgAV aged 1-6 years and 54 healthy children were included. Cases' age, sex, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), RNFL thicknesses, and choroidal thickness values were recorded. Read More

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Increased circulating innate lymphoid cell (ILC)1 and decreased circulating ILC3 are involved in the pathogenesis of Henoch-Schonlein purpura.

BMC Pediatr 2022 04 12;22(1):201. Epub 2022 Apr 12.

Department of Nephrology, Children's Hospital of Soochow University, No. 92, Zhong Nan Street, Industrial Park, Suzhou, 215003, Jiangsu, China.

Background: Innate lymphoid cell (ILC) dysfunction is involved in numerous immune diseases, but this has not been demonstrated in Henoch-Schonlein purpura (HSP). This study aimed to investigate whether ILC dysfunction or imbalance participate in the pathogenesis of HSP.

Methods: This was a prospective study in patients with HSP who were hospitalized at the Children's Hospital of Soochow University from June to December 2019. Read More

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Blood transthyretin for predicting immunoglobulin A vasculitis nephritis outcome in children.

Int Immunopharmacol 2022 Apr 6;108:108765. Epub 2022 Apr 6.

Pediatrics Department, the Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, China. Electronic address:

Background: IgA vasculitis is characterized by inflammation of the blood vessels, which can result in microvascular destruction and consequently renal damage. Transthyretin is a newly discovered angiogenesis regulator in promoting microvascular regeneration. This indicates that transthyretin may act as a potential predictor of IgAV as well as IgAVN. Read More

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New Insights and Challenges Associated With IgA Vasculitis and IgA Vasculitis With Nephritis-Is It Time to Change the Paradigm of the Most Common Systemic Vasculitis in Childhood?

Front Pediatr 2022 15;10:853724. Epub 2022 Mar 15.

Department of Clincial Sciences and Community Health, University of Milan, Milan, Italy.

What are the challenges ahead and how have we responded so far when it comes to the non-granulomatous systemic vasculitis, characterized mainly by deposits of IgA immune complexes in the endothelium of small blood vessels-IgA vasculitis (IgAV)? That is the question to which we tried to answer. We summarized existing knowledge about epidemiology, pathogenesis, genetics, diagnostic tests and therapy in this somewhat neglected entity in pediatric rheumatology. Since etiopathogenesis of IgA vasculitis is complex, with factors other than galactose-deficient IgA-containing immune complexes also being important, and may involve numerous interactions between environmental and genetic factors, genomics alone cannot explain the entirety of the risk for the disease. Read More

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Half of children with IgA vasculitis-associated nephritis with nephrotic state spontaneously recover.

Nephrology (Carlton) 2022 Apr 1. Epub 2022 Apr 1.

Department of Nephrology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.

Background: The clinical spectrum of Henoch-Schönlein purpura nephritis (HSPN), now known as IgA vasculitis-associated nephritis (IgAVN), ranges from isolated microscopic haematuria to nephrotic syndrome, progressive glomerulonephritis, and kidney failure. The outcome also varies, and the management of IgAVN is controversial. The presence of nephrotic state at disease onset is thought to be a risk factor of a poor prognosis. Read More

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Fluctuation of R2* values in blood oxygenation level-dependent MRI during acute and remission phases of IgA vasculitis with nephritis in children.

Jpn J Radiol 2022 Mar 31. Epub 2022 Mar 31.

Department of Pediatrics, Teikyo University School of Medicine, 2-11-1, Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.

Purpose: Noninvasive assessment of the kidney using blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) has progressed remarkably; indications have expanded to include the evaluation of glomerulonephritis. However, no longitudinal measurements from acute to post-treatment remission phases have been reported. Hence, this study aimed to investigate spin relaxation rate (R2*) values during acute and remission phases in children with glomerulonephritis. Read More

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Biologics for immunoglobulin A vasculitis: targeting vasculitis or comorbid disease?

Intern Emerg Med 2022 Mar 26. Epub 2022 Mar 26.

Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Hacettepe University Vasculitis Research Center, Sihhiye, 06100, Ankara, Turkey.

In this study, we aimed to evaluate the clinical features and treatments, including the use of biological disease-modifying anti-rheumatic drugs (bDMARDs) in a large cohort of pediatric and adult immunoglobulin A vasculitis (IgAV). Since data on the use of bDMARDs in IgAV are very limited, we collated the reasons for use of bDMARDs during the disease course. Patients who were enrolled in the Hacettepe University Vasculitis Research Centre (HUVAC) registry were included. Read More

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Autoimmune hepatitis and acquired partial lipodystrophy.

Frontline Gastroenterol 2022 14;13(2):175-177. Epub 2021 May 14.

Liver Unit (including Small Bowel Transplantation), Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.

The lipodystrophies are an extremely rare group of metabolic conditions which are categorised based on their pathogenesis and phenotype. While primarily known for the striking loss of subcutaneous adipose tissue which they induce, they may also be associated with significant liver injury. In most cases, this results from the secondary deposition of lipid within hepatic parenchyma and is seen predominantly in generalised lipodystrophy. Read More

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Glomerulonephritis with crescents in childhood; etiologies and significance of M2 macrophages.

Turk J Pediatr 2022 ;64(1):59-68

Divisions of Pediatric Pathology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Background: Crescentic glomerulonephritis (CGN) is a rapidly progressive and rare cause of glomerulonephritis in childhood. The aim of this study is to evaluate demographic data of children with crescentic glomerulonephritis, to classify the etiologies and to investigate the correlation between the severity of kidney disease and the expression of CD163+ macrophages.

Methods: Between the years 2000 and 2016 in a single center, patients under 18 years of age with kidney biopsies containing crescents were included in the study. Read More

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The Usefulness of Vanin-1 and Periostin as Markers of an Active Autoimmune Process or Renal Fibrosis in Children with IgA Nephropathy and IgA Vasculitis with Nephritis-A Pilot Study.

J Clin Med 2022 Feb 25;11(5). Epub 2022 Feb 25.

Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland.

This study aimed to evaluate the usefulness of vanin-1 and periostin in urine as markers of the autoimmune process in kidneys and renal fibrosis in IgA nephropathy (IgAN) and IgA vasculitis with nephritis (IgAVN). From a group of 194 patients from the Department of Pediatrics and Nephrology, who were included in the Polish Pediatric Registry of IgAN and IgAVN, we qualified 51 patients (20 with IgAN and 31 with IgAVN) between the ages of 3 and 17, diagnosed based on kidney biopsy, for inclusion in the study. All of the patients received glucocorticosteroids, immunosuppressive drugs, or renoprotective therapy. Read More

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February 2022

Let-7a Targeting TNFAPI3 Promotes Vascular Endothelial Cell Apoptosis of Pediatric Patients with Henoch-Schönlein Purpura via NF-B Signaling Pathway.

J Healthc Eng 2022 26;2022:3889318. Epub 2022 Feb 26.

Department of Pediatrics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No. 42, Wenhuaxi Road, Jinan, Shandong 250011, China.

Objective: We aimed at exploring the role of let-7a in the pathogenesis of pediatric Henoch-Schönlein purpura (HSP) and its related mechanism.

Methods: Fifty-five pediatric HSP patients and 20 paired healthy controls were included. The expressions of let-7a and TNFAIP3 were detected by RT-qPCR or/and western blot. Read More

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Challenges in Evaluating Pediatric Fever and Rash in the Era of COVID-19 and Multisystem Inflammatory Syndrome in Children (MIS-C).

Cureus 2022 Jan 31;14(1):e21764. Epub 2022 Jan 31.

Department of Emergency and Hospital Medicine, University of South Florida Morsani College of Medicine, Lehigh Valley Health Network Campus, Allentown, USA.

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has challenged the medical community to characterize and treat a new illness. Now almost two years after the initial confirmed cases of COVID-19, medical teams are faced with another unique disease process temporally related to the pandemic-multisystem inflammatory syndrome in children (MIS-C). The comparison of these patients' presentations illustrates the new challenges of evaluating a pediatric rash and fever in the era of MIS-C. Read More

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January 2022

Perspective on COVID-19 vaccination in patients with immune-mediated kidney diseases: consensus statements from ERA-IWG and EUVAS.

Nephrol Dial Transplant 2022 Mar 4. Epub 2022 Mar 4.

Department of Medicine, University of Cambridge, UK.

Patients with immune-mediated kidney diseases are at increased risk of severe COVID-19. The international rollout of COVID-19 vaccines has provided varying degrees of protection and enabled the understanding of vaccine efficacy and safety. The immune response to COVID-19 vaccines is lower in most patients with immune-mediated kidney diseases; either related to immunosuppression or to co-morbidities and complications caused by the underlying disease. Read More

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IgA Vasculitis Without Typical Skin Rash Concomitated With c-ANCA Positivity.

Clin Med Insights Case Rep 2022 25;15:11795476221077790. Epub 2022 Feb 25.

Pediatrics, Alhada Armed Forces Hospital, Taif, Kingdom of Saudi Arabia.

We describe a case of IgA vasculitis without typical skin rash concomitated with c-ANCA positivity in a 6-year-old boy who presented with persistent severe generalized colicky abdominal pain, recurrent episodes of vomiting, non-pitting edema of both hands and feet, both knees and ankles arthritis with no associated skin rash following a history of an upper respiratory tract infection 2 weeks before presentation. Initially, he had normal laboratory findings apart from sub-nephrotic range proteinuria and microscopic hematuria in his urine analysis. Two weeks later, he started to have hypertension, gross hematuria, nephrotic range proteinuria, marked elevation of serum urea and creatinine associated with positive serum C-ANCA. Read More

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February 2022

The scope of treatment of pediatric IgA vasculitis nephritis and its outcome: a Pediatric Nephrology Research Consortium study.

Pediatr Nephrol 2022 Mar 2. Epub 2022 Mar 2.

Pediatric Nephrology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Background: IgA vasculitis (IgAV) is the most common type of vasculitis in children. There is a lack of consensus for management of significant IgAV nephritis (IgAVN). This study was designed to identify the most used treatment options and describe their efficacy. Read More

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Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review.

Children (Basel) 2022 Feb 15;9(2). Epub 2022 Feb 15.

Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

Acute hemorrhagic edema of young children, a benign skin-limited vasculitis, predominantly affects children 2 years of age or younger. The prevalence and clinical features of the Köbner and Pastia signs have never been systematically investigated in this vasculitis. To address this issue, we analyzed the data contained in the Acute Hemorrhagic Edema Bibliographic Database, which incorporates all reports on hemorrhagic edema published after 1969. Read More

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February 2022

Henoch-Schönlein Purpura /IgA Vasculitis Complicated by Coronary Artery Aneurysm: A Case Report and Literature Review.

Front Pediatr 2021 3;9:781106. Epub 2022 Feb 3.

Department of Nephrology, Rheumatology and Immunology, Hunan Children's Hospital, Changsha, China.

Henoch-Schönlein purpura (HSP)/ IgA vasculitis (IgAV) is the most common form of systemic vasculitis in children and often involves the skin, gastrointestinal tract, joints, and kidneys, though cardiac involvement rarely occurs. We report on a 6-year-old male child with HSP/IgAV who had renal and cardiac involvement at the initial stage of the disease and in whom we found an extremely rare coronary artery aneurysm. After administration of glucocorticoid combined with mycophenolate mofetil, the renal involvement improved, but the coronary artery aneurysm remained. Read More

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February 2022

Atypical purpura and other features associated with unfavorable outcomes of IgA vasculitis (Henoch-Schönlein purpura) in children: A retrospective study.

Pediatr Dermatol 2022 Feb 17. Epub 2022 Feb 17.

Dermatology Department, National Institute for Pediatrics, Mexico City, Mexico.

The prognosis of IgA vasculitis (also known as Henoch-Schönlein purpura) is determined by renal or other organ involvement. We conducted a retrospective study to identify the initial features of 106 children with IgA vasculitis and their association with unfavorable outcomes. Location of purpura above the waist and an altered urinalysis at diagnosis predicted a more aggressive course of disease. Read More

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February 2022

A predictive system for Henoch-Schönlein purpura nephritis established by multivariate analysis plus nomogram model in Chinese hospitalized children: A retrospective cohort study.

J Am Acad Dermatol 2022 Feb 12. Epub 2022 Feb 12.

Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China. Electronic address:

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February 2022

Lipid metabolism contribute to the pathogenesis of IgA Vasculitis.

Diagn Pathol 2022 Feb 11;17(1):28. Epub 2022 Feb 11.

Institute of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.

Background And Objectives: The underlying mechanism of IgA vasculitis (IgAV) and IgA vasculitis with nephritis (IgAVN) remains unclear. Therefore, there are no accurate diagnostic methods. Lipid metabolism is related to many immune related diseases, so this study set out to explore the relationship of lipids and IgAV and IgAVN. Read More

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February 2022

Integrated Analyses of Gut Microbiome and Host Metabolome in Children With Henoch-Schönlein Purpura.

Front Cell Infect Microbiol 2021 25;11:796410. Epub 2022 Jan 25.

Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.

Recent studies have shown that intestinal microbes and metabolites are involved in the pathogenesis of many diseases. However, whether and how they are related to Henoch-Schönlein purpura (HSP) has yet to be understood. This work is designed to detect gut microbes, intestinal and serum metabolites in children with HSP, trying to discover the etiology and pathogenesis of HSP. Read More

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Prediction of More Severe MEFV Gene Mutations in Childhood.

Turk Arch Pediatr 2021 Nov;56(6):610-617

Department of Pediatric Nephrology, University of Health Sciences School of Medicine, İzmir, Turkey.

Aim: This study aimed to present the demographic, clinical, and laboratory features of children clinically diagnosed with familial Mediterranean fever (FMF) and to predict more severe mutations by evaluating those findings.

Methods: We enrolled cases diagnosed with FMF with a defined variation in at least one allele. The medical charts of the patients were reviewed retrospectively. Read More

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November 2021

A boy with purpura and generalized edema: Answers.

Pediatr Nephrol 2022 Jan 27. Epub 2022 Jan 27.

Division of Rheumatology, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

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January 2022

Comparison and Analysis of Gut Microbiota in Children With IgA Vasculitis With Different Clinical Symptoms.

Front Pediatr 2021 7;9:800677. Epub 2022 Jan 7.

Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.

Henoch-Schönlein purpura, now called immunoglobulin A (IgA) vasculitis, is a common autoimmune disease in children, its association with gut microbiota composition remains unknown. The collected cases were divided into three groups: G1 group of simple skin type, G2 group with no digestive tract expression, G3 group of mixed digestive tract, and C group of healthy children. The fecal samples of each group of children were collected and the sequencing data was processed and analyzed. Read More

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January 2022

Risk factors of renal trauma in children with severe Henoch-Schonlein purpura and effect of mycophenolate mofetil on pediatric renal function.

Transl Pediatr 2021 Dec;10(12):3166-3174

Department of Pediatrics Internal Medicine Shengli Oilfield Central Hospital, Dongying, China.

Background: Renal trauma (RT) is a common feature in children with severe Henoch-Schonlein purpura (HSP), which can elevate the chance of recurrence and trigger end-stage renal disease. The risk factors of RT in children with HSP were explored and research was conducted on relevant treatment methods.

Methods: A total of 120 child patients with severe HSP admitted to our hospital from January 2019 to January 2020 were selected as the research cohort, and divided into a RT group (n=45) and RT-free group (n=75) according to their condition to analyze the risk factors inducing RT in pediatric patients, and mycophenolate mofetil therapy was given to both participant groups to compare their renal function indicators, immune function indicators, and adverse reaction rates (ARR) after treatment. Read More

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December 2021