818 results match your criteria Pediatrics Henoch-Schonlein Purpura


IgA1 isolated from Henoch-Schonlein Purpura children promotes proliferation of human mesangial cells in vitro.

Cell Biol Int 2019 Apr 8. Epub 2019 Apr 8.

Department of Anatomy, , Anhui Medical University, Hefei, Anhui, China.

Previous studies show that the proliferation of human mesangial cells (HMCs) played a significant part in the pathogenesis of Henoch-Schönlein purpura nephritis (HSPN). The aim of this study was to explore the proliferation of HMCs induced by IgA1 isolated from sera of Henoch-Schönlein purpura (HSP) patients. HMCs were cultured in three different types of media, including IgA1 from patients with HSP (HSP IgA1 group), healthy children (healthy IgA1 group) and medium (control group). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cbin.11142
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http://dx.doi.org/10.1002/cbin.11142DOI Listing
April 2019
2 Reads

Methylprednisolone or cyclosporine a in the treatment of Henoch-Schönlein nephritis: a nationwide study.

Pediatr Nephrol 2019 Apr 6. Epub 2019 Apr 6.

Department of Pediatric Nephrology and Transplantation, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 9, 00290, Helsinki, Finland.

Background: Optimal treatment of Henoch-Schönlein purpura nephritis (HSN) remains unclear. We evaluated outcome of pediatric HSN patients treated initially with either methylprednisolone (MP) or cyclosporine A (CyA) in Finland between 1996 and 2011.

Methods: Outcome of 62 HSN patients was evaluated by screening urine and blood samples (n = 51) or by collecting clinical parameters from medical charts until last follow-up visit (n = 11). Read More

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http://dx.doi.org/10.1007/s00467-019-04238-2DOI Listing
April 2019
3 Reads

European consensus-based recommendations for diagnosis and treatment of immunoglobulin A vasculitis-the SHARE initiative.

Rheumatology (Oxford) 2019 Mar 16. Epub 2019 Mar 16.

Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

Objectives: IgA vasculitis (IgAV, formerly known as Henoch-Schönlein purpura) is the most common cause of systemic vasculitis in childhood. To date, there are no internationally agreed, evidence-based guidelines concerning the appropriate diagnosis and treatment of IgAV in children. Accordingly, treatment regimens differ widely. Read More

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/kez041DOI Listing
March 2019
4 Reads

Analysis of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and mean platelet volume to platelet count ratio in children with acute stage of immunoglobulin A vasculitis and assessment of their suitability for predicting the course of the disease.

Rheumatol Int 2019 Mar 13. Epub 2019 Mar 13.

Department of Paediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, ul. 3-go Maja 13-15, 41-800, Zabrze, Poland.

Immunoglobulin A vasculitis (IgAV) is the most common systemic vasculitis in developmental age. The disease is most often characterized by a self-limiting course and good prognosis, but sometimes serious complications, like gastrointestinal bleeding or glomerulonephritis, may develop. The neutrophil to lymphocyte (NLR) and the platelet to lymphocyte (PLR) ratios are indicators related to clinical outcome in various inflammatory diseases. Read More

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http://dx.doi.org/10.1007/s00296-019-04274-zDOI Listing
March 2019
4 Reads

Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch-Schönlein purpura: a meta-analysis.

J Renin Angiotensin Aldosterone Syst 2019 Jan-Mar;20(1):1470320319836302

Department of Pediatrics, Hangzhou Hospital of Traditional Chinese Medicine, China.

Objective:: Meta-analysis was performed in the current study to evaluate the relationship of the angiotensin-converting enzyme insertion/deletion polymorphism with the risk of the incidence of Henoch-Schönlein purpura.

Methods:: The electronic databases, including Embase, PubMed and Google scholar, were systemically retrieved to search for related articles. Meanwhile, statistical analysis was performed using the odds ratio and the corresponding 95% confidence interval. Read More

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http://dx.doi.org/10.1177/1470320319836302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413430PMC

Exercise-Induced Purpura in Children.

Pediatrics 2019 Apr 7;143(4). Epub 2019 Mar 7.

Penn State Children's Hospital, Hershey, Pennsylvania.

Exercise-induced purpura, which has also been called "golfer's purpura," is a phenomenon that has been rarely reported in the pediatric literature. This is the first case series in which this benign vasculopathy, which is most often associated with warm weather and high-impact activity, is described. In this series, we describe 5 patients, most of whom had an erythematous purpuric rash above the sock line that extended to the knees and was associated with warm weather and prolonged activity. Read More

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http://dx.doi.org/10.1542/peds.2018-2797DOI Listing

Different histological classifications for Henoch-Schönlein purpura nephritis: which one should be used?

Pediatr Rheumatol Online J 2019 Feb 28;17(1):10. Epub 2019 Feb 28.

Department of Pediatrics, Hacettepe University, Ankara, Turkey.

Background: Nephritis is the most important chronic complication of IgA Vasculitis (IgAV)/Henoch-Schönlein purpura (IGAV/HSP) and thus the main prognostic factor of this most common childhood vasculitis. Since the prognosis and treatment selection depends on the mode of interpretation of biopsy material, in this manuscript we have presented several issues related to the uneven application of different histological classifications in IgAV/Henoch-Schönlein purpura nephritis (HSPN). The nephritis of IgAV/IGAV/HSP will be abbreviated as HSPN for this paper. Read More

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http://dx.doi.org/10.1186/s12969-019-0311-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393980PMC
February 2019
1 Read

Pediatric Rheumatology Curriculum for the Pediatrics Resident: A Case-Based Approach to Learning.

MedEdPORTAL 2018 Oct 26;14:10767. Epub 2018 Oct 26.

Assistant Professor, Department of Pediatrics, Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine at Texas Children's Hospital.

Introduction: Pediatric rheumatologic disease occurs more frequently than several other chronic pediatric diseases but is often underrecognized. It is estimated that in the US, one in 250 children has some form of juvenile arthritis and 300,000 children have a form of rheumatologic disease. However, there are only approximately 400 practicing pediatric rheumatologists nationwide. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342410PMC
October 2018
2 Reads

Tubulointerstitial Infiltration of M2 Macrophages in Henoch-Schönlein Purpura Nephritis Indicates the Presence of Glomerular Crescents and Bad Clinical Parameters.

Biomed Res Int 2019 20;2019:8579619. Epub 2019 Jan 20.

Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children, and renal involvement (HSP nephritis, HSPN) is a severe manifestation. HSPN is histologically classified by the International Study of Kidney Disease in Children (ISKDC) based on mesangial hypercellularity and the extent of glomerular crescents. Macrophages, categorized as M1 or M2, frequently infiltrate in various glomerular and tubulointerstitial diseases and infiltration of specific subtypes is associated with disease progression. Read More

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http://dx.doi.org/10.1155/2019/8579619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360621PMC
January 2019
1 Read

[Value of galactose-deficient IgA1 in the early diagnosis of Henoch-Schönlein purpura nephritis in children].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):172-175

Department of Nephrology and Rheumatology, Hunan Children's Hospital/Academy of Pediatrics of University of South China, Changsha 410007, China.

Objective: To explore the value of galactose-deficient IgA1 (Gd-IgA1) in the early diagnosis of Henoch-Schönlein purpura nephritis (HSPN) in children.

Methods: A total of 67 hospitalized children who were definitely diagnosed with HSPN between January and April 2018 and 58 hospitalized children with Henoch-Schönlein purpura (HSP) were enrolled in the study. Twenty children undergoing routine physical examinations served as controls. Read More

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February 2019
1 Read

Clinical course & management of childhood nephrotic syndrome in Germany: a large epidemiological ESPED study.

BMC Nephrol 2019 Feb 7;20(1):45. Epub 2019 Feb 7.

Department of Radiology, Pediatric Radiology, University Hospital of Bonn, Bonn, Germany.

Background: Nephrotic syndrome (NS) is one of the most frequent occurring chronic kidney diseases in childhood, despite its rarely occurrence in the general population. Detailed information about clinical data of NS (e.g. Read More

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http://dx.doi.org/10.1186/s12882-019-1233-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367765PMC
February 2019
10 Reads

Hemorrhagic Bullous Henoch-Schönlein Purpura: Case Report and Review of the Literature.

Front Pediatr 2018 22;6:413. Epub 2019 Jan 22.

Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany.

Henoch-Schönlein Purpura (HSP) or IgA vasculitis is the most common systemic vasculitis of childhood and may affect skin, joints, gastrointestinal tract, and kidneys. Skin manifestations of HSP are characteristic and include a non-thrombocytopenic palpable purpura of the lower extremities and buttocks. Rarely, HSP may initially present as or evolve into hemorrhagic vesicles and bullae. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00413/
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http://dx.doi.org/10.3389/fped.2018.00413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349767PMC
January 2019
17 Reads

The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch-Schonlein purpura: A PRISMA-compliant meta-analysis.

Medicine (Baltimore) 2019 Jan;98(3):e13991

Department of Pediatrics.

Background: To date, the relationship of Th17 and Treg cells to Henoch-Schonlein purpura (HSP) in children remains controversial. Therefore, a systematic review and meta-analysis was conducted to reveal the potential role of the Th17 and Treg cells in children in acute stage of HSP.

Methods: PubMed, Embase, Web of Science and China National Knowledge Internet (CNKI) were systematically searched for eligible studies up to November 03, 2017. Read More

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http://dx.doi.org/10.1097/MD.0000000000013991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370168PMC
January 2019
2 Reads
5.723 Impact Factor

Differential expression of long non-coding RNA and mRNA in children with Henoch-Schönlein purpura nephritis.

Exp Ther Med 2019 Jan 30;17(1):621-632. Epub 2018 Nov 30.

Department of Pediatrics, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110032, P.R. China.

Long non-coding RNAs (lncRNAs) serve an essential role in regulating immunological functions. However, their impact on Henoch-Schönlein purpura nephritis (HSPN), has remained elusive. The present study determined the expression of lncRNAs and mRNAs in the peripheral blood of 6 children with HSPN and recruited 4 healthy children for comparative study. Read More

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http://www.spandidos-publications.com/10.3892/etm.2018.7038
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http://dx.doi.org/10.3892/etm.2018.7038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307475PMC
January 2019
10 Reads

Direct Immunofluorescence Results of the Skin Biopsy and Frequency of Systemic Involvement in Children with Henoch-Schonlein Purpura.

Fetal Pediatr Pathol 2019 Jan 2:1-6. Epub 2019 Jan 2.

b Department of Pathology , Tehran University of Medical Sciences , Tehran , Iran.

Objective: Henoch-Schonlein purpura (HSP) is a common vasculitis in children that can present with multi-organ involvement. The aim of this study is to investigate the correlation between direct immunofluorescence (DIF) results and the systemic involvements of the HSP in pediatric patients.

Material And Methods: Those HSP patients with leukocytoclastic vasculitis on their biopsies who also had documented immunoglobulin/complement deposition by DIF were included in our study. Read More

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http://dx.doi.org/10.1080/15513815.2018.1552733DOI Listing
January 2019
4 Reads

Successful treatment of hemorrhagic bullous Henoch-Schonlein purpura with intravenous immunoglobulins.

Pediatr Dermatol 2019 Jan 18;36(1):e34-e36. Epub 2018 Dec 18.

Department of Paediatrics, Santobono-Pausilipon Children's Hospital, Naples, Italy.

Henoch-Schonlein purpura (HSP) is the most common systemic vasculitis in childhood. There is no consensus about the management for isolated cutaneous manifestations in HSP. We describe a case of HSP presenting with severe skin lesions that did not respond to standard therapy with corticosteroids. Read More

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http://dx.doi.org/10.1111/pde.13715DOI Listing
January 2019
2 Reads

Predisposing factors of childhood Henoch-Schönlein purpura in Anhui province, China.

J Investig Med 2019 Apr 6;67(4):771-778. Epub 2018 Dec 6.

Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Henoch-Schönlein purpura (HSP) is a common autoimmune vasculitis in childhood. The detailed pathogenesis of HSP is still unclear, whereas several types of predisposing factors have been proved to be the initial step. The objectives of present study were to analyze the distribution of predisposing factors, association of the predisposing factors with clinical manifestations and HSP relapse/recurrence. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000906
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http://dx.doi.org/10.1136/jim-2018-000906DOI Listing
April 2019
19 Reads
1.503 Impact Factor

Features distinguishing juvenile idiopathic arthritis among children with musculoskeletal complaints.

World J Pediatr 2018 Nov 29. Epub 2018 Nov 29.

Division of Rheumatology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Background: Musculoskeletal (MSK) complaints in children vary, ranging from benign, self-limited conditions to serious disorders. Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease, initially presenting with MSK complaints. Delayed diagnosis and appropriate treatment have an enormous impact on the long-term outcomes and the level of disability. Read More

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http://dx.doi.org/10.1007/s12519-018-0212-0DOI Listing
November 2018
5 Reads

Rare and striking complication of Henoch-Schönlein purpura.

Arch Dis Child 2018 Nov 23. Epub 2018 Nov 23.

Department of Pediatrics, University Hospitals Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1136/archdischild-2018-316134DOI Listing
November 2018
1 Read

Cord-derived mesenchymal stem cells therapy for liver cirrhosis in children with refractory Henoch-Schonlein purpura: A case report.

Medicine (Baltimore) 2018 Nov;97(47):e13287

Department of Pediatrics, Shandong Provincial Qianfoshan Hospital of Shandong University, Jinan, China.

Rationale: To explore the curative effect of human umbilical cord-derived mesenchymal stem cell (ucMSC) therapy for patients with liver cirrhosis complicated with immune thrombocytopenia and refractory Henoch-Schonlein purpura (HSP).

Patient Concerns: A 12-year-old boy presented to our hospital with an 11-month history of purpura on the skin of both lower limbs accompanied by thrombocytopenia. The patient had a history of repeated swelling and painful dorsum pedis, followed by skin redness. Read More

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http://dx.doi.org/10.1097/MD.0000000000013287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392614PMC
November 2018
23 Reads

Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis.

Pediatr Clin North Am 2019 02;66(1):101-110

Department of Pediatrics, Medical University of South Carolina, 96 Jonathan Lucas Street, 428 CSB, MSC 608, Charleston, SC 29425, USA. Electronic address:

Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are common glomerulopathies in the pediatric population that deserve special attention. In some cases the primary care provider can follow the patient but others need more intensive management. Delaying this treatment can lead to worse morbidity. Read More

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http://dx.doi.org/10.1016/j.pcl.2018.08.008DOI Listing
February 2019
3 Reads

Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study.

Kidney Int Rep 2018 Nov 3;3(6):1373-1384. Epub 2018 Aug 3.

Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, New York, USA.

Introduction: The Cure Glomerulonephropathy Network (CureGN) is a 66-center longitudinal observational study of patients with biopsy-confirmed minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or IgA nephropathy (IgAN), including IgA vasculitis (IgAV). This study describes the clinical characteristics and treatment patterns in the IgA cohort, including comparisons between IgAN versus IgAV and adult versus pediatric patients.

Methods: Patients with a diagnostic kidney biopsy within 5 years of screening were eligible to join CureGN. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24680249183017
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http://dx.doi.org/10.1016/j.ekir.2018.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224619PMC
November 2018
13 Reads

Rituximab treatment for chronic steroid-dependent Henoch-Schonlein purpura: 8 cases and a review of the literature.

Pediatr Rheumatol Online J 2018 Nov 14;16(1):71. Epub 2018 Nov 14.

Department of Pediatrics, Division of Rheumatology, University of Alabama at Birmingham, 1600 7th Ave S, CPPN G10, Birmingham, AL, 35233, USA.

Background: Henoch-Schonlein purpura (HSP) is a small vessel vasculitis that is characterized by non-thrombocytopenic purpura, abdominal pain, arthritis, and glomerulonephritis. Typically, HSP is self-limited requiring only supportive care, but more severe cases may require corticosteroid (CS) treatment. Rarely, a subset of these patients has persistent rash, arthritis, abdominal involvement, or renal disease despite treatment with CS, or has disease recurrence on CS tapering. Read More

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https://ped-rheum.biomedcentral.com/articles/10.1186/s12969-
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http://dx.doi.org/10.1186/s12969-018-0285-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236882PMC
November 2018
36 Reads

CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease.

Am J Kidney Dis 2019 Feb 9;73(2):218-229. Epub 2018 Nov 9.

Center for Translational Science, Children's National Health System, Washington, DC.

Rationale & Objectives: Glomerular diseases, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A (IgA) nephropathy, share clinical presentations, yet result from multiple biological mechanisms. Challenges to identifying underlying mechanisms, biomarkers, and new therapies include the rarity of each diagnosis and slow progression, often requiring decades to measure the effectiveness of interventions to prevent end-stage kidney disease (ESKD) or death.

Study Design: Multicenter prospective cohort study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02726386183093
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http://dx.doi.org/10.1053/j.ajkd.2018.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348011PMC
February 2019
26 Reads

Correlation between endocapillary proliferative and nephrotic-range proteinuria in children with Henoch-Schönlein purpura nephritis.

Pediatr Nephrol 2019 Apr 10;34(4):663-670. Epub 2018 Nov 10.

Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA.

Background: The endocapillary proliferative (EP) lesion is not included in the International Study of Kidney Disease in Children (ISKDC) pathological classification of Henoch-Schönlein purpura nephritis (HSPN). The main objective of the study was to determine the pathological importance of EP in the development of proteinuria in children with Henoch-Schönlein purpura nephritis (HSPN).

Methods: The pathological features of 148 HSPN children with nephrotic-range proteinuria were investigated retrospectively. Read More

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http://link.springer.com/10.1007/s00467-018-4134-9
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http://dx.doi.org/10.1007/s00467-018-4134-9DOI Listing
April 2019
16 Reads
2.860 Impact Factor

Oral microbiota dysbiosis and its association with Henoch-Schönlein Purpura in children.

Int Immunopharmacol 2018 Dec 17;65:295-302. Epub 2018 Oct 17.

Shandong Children's Microbiome Center, Qilu Children's Hospital of Shandong University, Jinan 250022, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Chemistry and Environment, Beihang University, Beijing 100191, China; Qingdao Human Microbiome Center, The Affiliated Central Hospital of Qingdao University, Qingdao 266042, China. Electronic address:

Background: The pathogenesis of microbes in allergic diseases has been demonstrated and our previous research indicates that microbiota causing gut disorders in children is associated with Henoch-Schönlein Purpura. However, the role of oral microbiota in Henoch-Schönlein Purpura remains unknown.

Method: A total of 164 children were enrolled, of which 98 were patients with HSP and 66 were healthy children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183086
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http://dx.doi.org/10.1016/j.intimp.2018.10.017DOI Listing
December 2018
12 Reads
2.470 Impact Factor

Defining significant childhood illness and injury in the Emergency Department: a consensus of UK and Ireland expert opinion.

Emerg Med J 2018 Nov 3;35(11):685-690. Epub 2018 Oct 3.

Department of Paediatric Emergency Medicine, Imperial College NHS Trust, London, UK.

Background: Clarifying whether paediatric early warning scores (PEWS) accurately predict significant illness is a research priority for UK and Ireland paediatric emergency medicine (EM). However, a standardised list of significant conditions to benchmark these scores does not exist.

Objectives: To establish standardised significant illness endpoints for use in determining the performance accuracy of PEWS and safety systems in emergency departments (ED), using a consensus of expert opinion in the UK and Ireland. Read More

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http://dx.doi.org/10.1136/emermed-2018-207802DOI Listing
November 2018
9 Reads

Effect of Montmorillonite powder on intestinal mucosal barrier in children with abdominal Henoch-Schonlein purpura: A randomized controlled study.

Medicine (Baltimore) 2018 Sep;97(39):e12577

Open Laboratory, West China Institute for Women's and Children's Health, Chengdu, Sichuan Province, China.

Background: Our previous studies found that intestinal barrier function has been changed in children with abdominal Henoch-Schonlein purpura (HSP). Montmorillonite has been shown to be protective for digestive tract mucosa.

Objective: The present study aimed to investigate whether Montmorillonite powder could improve the intestinal mucosal barrier function in children with abdominal HSP. Read More

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http://Insights.ovid.com/crossref?an=00005792-201809280-0008
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http://dx.doi.org/10.1097/MD.0000000000012577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181592PMC
September 2018
7 Reads

Risk factors for renal involvement and severe kidney disease in 2731 Chinese children with Henoch-Schönlein purpura: A retrospective study.

Medicine (Baltimore) 2018 Sep;97(38):e12520

Department of Pediatrics.

To identify the risk factors for developing renal involvement and severe kidney disease in Chinese childhood Henoch-Schönlein purpura (HSP) patients.This was a retrospective study of 2731 children with HSP diagnosed between 2012 and 2015. We analyzed their demographic data, clinical manifestations, and laboratory tests retrospectively. Read More

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http://dx.doi.org/10.1097/MD.0000000000012520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160025PMC
September 2018
11 Reads

Analysis of seasonal tendencies in pediatric Henoch-Schönlein purpura and comparison with outbreak of infectious diseases.

Medicine (Baltimore) 2018 Sep;97(36):e12217

Department of Pediatrics.

Henoch-Schönlein purpura (HSP) is one of the most common vasculitis in children. This study was aimed at identifying seasonal trends and epidemiologic features of pediatric HSP patients through public data to analyze the correlation of HSP and prevalence of a specific respiratory or enteric virus.We extracted information on pediatric HSP patients categorized into 4 age groups and data on 8 respiratory and 4 enteric viruses were extracted from national data. Read More

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http://Insights.ovid.com/crossref?an=00005792-201809070-0008
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http://dx.doi.org/10.1097/MD.0000000000012217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133644PMC
September 2018
3 Reads

Vasculitis Pathogenesis: Can We Talk About Precision Medicine?

Front Immunol 2018 14;9:1892. Epub 2018 Aug 14.

Division of Rheumatology, Department of Pediatrics, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey.

Precision medicine is designing the medical care by taking into account the individual variability for each person. We have tried to address whether the existing data may guide precision medicine in primary systemic vasculitides (PSV). We have reviewed genome-wide association studies (GWAS) data, lessons from monogenic mimics of these diseases, and biomarker studies in immunoglobulin A vasculitis/Henoch-Schönlein purpura, Kawasaki disease, anti-neutrophil cytoplasmic antibody-associated vasculitis, polyarteritis nodosa (PAN), Takayasu arteritis, and Behçet's disease (BD). Read More

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http://dx.doi.org/10.3389/fimmu.2018.01892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102378PMC
August 2018
5 Reads

Henoch-Schönlein Purpura Presenting With Subcutaneous Edema: A Case Report and a Proposal to Include Subcutaneous Edema as a Diagnostic Criterion.

J Clin Rheumatol 2018 Aug 23. Epub 2018 Aug 23.

Department of Pediatrics Staten Island University Hospital Northwell Health Staten Island, NY

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http://dx.doi.org/10.1097/RHU.0000000000000811DOI Listing
August 2018
3 Reads

Significance of glomerular fibrinogen deposition in children with Henoch-Schönlein purpura nephritis.

Ital J Pediatr 2018 Aug 16;44(1):97. Epub 2018 Aug 16.

Department of Pathology, Soochow University Affiliated Children's Hospital, Suzhou, Jiangsu, China.

Background: Henoch-Schönlein purpura nephritis (HSPN) is the most common pediatric secondary glomerular disease. This study aimed to investigate the significance of glomerular fibrinogen (Fib) deposition in children with HSPN.

Methods: Eighty-two patients with HSPN were enrolled retrospectively at the Children's Hospital of Soochow University from January 2015 to March 2017. Read More

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http://dx.doi.org/10.1186/s13052-018-0538-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097424PMC
August 2018
12 Reads

Is Henoch-Schönlein purpura a susceptibility factor for functional gastrointestinal disorders in children?

Rheumatol Int 2019 Feb 12;39(2):317-322. Epub 2018 Aug 12.

Department of Pediatric Rheumatology, Cukurova University Faculty of Medicine, Adana, Turkey.

Henoch-Schönlein purpura (HSP), the most common childhood vasculitis is characterized by non-thrombocytopenic palpable purpura, arthritis/arthralgia, abdominal pain and renal involvement. Functional gastrointestinal disorders (FGIDs) are heterogeneous disease spectrum with unclear etiology and include the most common subtypes: functional dyspepsia, irritable bowel syndrome (IBS), functional abdominal pain and functional constipation. Formerly, FGIDs were known as non-organic disorders; however, recent advances revealed that low-grade inflammation may also play a role. Read More

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http://dx.doi.org/10.1007/s00296-018-4129-7DOI Listing
February 2019
18 Reads

Clinicopathological features of pediatric renal biopsies in the plateau regions of China.

J Int Med Res 2018 Nov 20;46(11):4539-4546. Epub 2018 Jul 20.

1 Department of Pediatrics, West China Second University Hospital, Sichuan University, Sichuan Province, China.

Objective: This study aimed to analyze the clinicopathological features of pediatric renal biopsies from plateau regions of China.

Methods: Clinicopathological features of pediatric renal biopsies were compared between plateau and non-plateau regions in patients who were admitted to West China Second University Hospital, Sichuan University between April 2001 and March 2017. Patients were children younger than 18 years. Read More

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http://dx.doi.org/10.1177/0300060518786908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259398PMC
November 2018
11 Reads
1.095 Impact Factor

Pulmonary renal syndrome in Henoch-Schönlein purpura.

Arch Dis Child 2018 Jul 2. Epub 2018 Jul 2.

Department of Paediatric Rheumatology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1136/archdischild-2018-315030DOI Listing
July 2018
2 Reads

Neutrophil-to-lymphocyte ratio to predict gastrointestinal bleeding in Henoch: Schönlein purpura.

Pediatr Int 2018 Sep 5;60(9):791-795. Epub 2018 Sep 5.

Department of Pediatrics, Chonnam National University Hospital, Gwangju, Korea.

Background: Henoch-Schönlein purpura (HSP) is a common form of vasculitis in children. It typically involves small vessels of the skin, the gastrointestinal (GI) tract, joints, and kidneys. GI involvement is the most severe short-term complication and GI bleeding is a major complication of HSP, but there is no established predictive marker of GI bleeding. Read More

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http://dx.doi.org/10.1111/ped.13652DOI Listing
September 2018
17 Reads

What We Know about Henoch-Schönlein Purpura in Children up to Date?

Authors:
Hye Ran Yang

J Korean Med Sci 2018 06 7;33(25):e199. Epub 2018 Jun 7.

Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

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http://dx.doi.org/10.3346/jkms.2018.33.e199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000601PMC
June 2018
6 Reads

Ten-year Nationwide Population-based Survey on the Characteristics of Children with Henoch-Schӧnlein Purpura in Korea.

J Korean Med Sci 2018 Jun 14;33(25):e174. Epub 2018 May 14.

Department of Pediatrics, Inje University College of Medicine, Seoul, Korea.

Background: Henoch-Schӧnlein purpura (HSP) is a common vasculitis of childhood. Though HSP is usually self-limiting, severe complications can occur. The management for this condition has not been established yet. Read More

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http://dx.doi.org/10.3346/jkms.2018.33.e174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000599PMC
June 2018
5 Reads

The Spectrum of Biopsy-Proven Glomerular Diseases among Children in China: A National, Cross-Sectional Survey.

Clin J Am Soc Nephrol 2018 Jul 18;13(7):1047-1054. Epub 2018 Jun 18.

The National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Renal Division, Nanfang Hospital and

Background And Objectives: High-quality epidemiologic data on the spectrum of biopsy-proven glomerular diseases among children are limited. This study aimed to determine the profile of and temporal change in biopsy-proven pediatric glomerular diseases in China.

Design, Setting, Participants, & Measurements: We previously conducted a nationwide kidney biopsy survey including 71,151 patients over an 11-year period from January 2004 to December 2014. Read More

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http://dx.doi.org/10.2215/CJN.11461017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032591PMC
July 2018
55 Reads

Comparing immunoglobulin A vasculitis (Henoch-Schönlein purpura) in children and adults: a single-centre study from Turkey.

Scand J Rheumatol 2018 Nov 18;47(6):481-486. Epub 2018 Jun 18.

a Division of Rheumatology, Department of Pediatrics , Hacettepe University Faculty of Medicine , Ankara , Turkey.

Objective: Immunoglobulin A vasculitis/Henoch-Schönlein purpura (IgAV/HSP) is a systemic vasculitis involving small vessels with the deposition of immune complexes containing IgA. It is the most common primary systemic vasculitis of childhood and is much less common in adults. Our aim was to investigate the differences and similarities between adult and paediatric patients with IgAV/HSP. Read More

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http://dx.doi.org/10.1080/03009742.2018.1448111DOI Listing
November 2018
11 Reads

Unusual presentation of Henöch-Schonlein purpura.

BMJ Case Rep 2018 May 30;2018. Epub 2018 May 30.

Bedford Hospital NHS Trust, Bedford, UK.

We present a rare case of a 4-year-old boy with newly diagnosed Henöch-Schonlein purpura (HSP) affecting the scrotum and penis. The patient presented to the emergency department with palpable purpura symmetrically distributed over the lower limbs. This was associated with arthritis of the right knee, abdominal pain and scrotal swelling. Read More

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http://dx.doi.org/10.1136/bcr-2017-220129DOI Listing
May 2018
6 Reads

Can such an animal model truly represent Henoch-Schönlein purpura?

Arch Dermatol Res 2018 Aug 14;310(6):533. Epub 2018 May 14.

Department of Nephrology and Rheumatology, Children's Hospital of Soochow University, Jingde Street 303, Suzhou, 215000, Jiangsu, China.

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http://dx.doi.org/10.1007/s00403-018-1838-4DOI Listing
August 2018
8 Reads

Down-Regulation of miR-218-5p Promotes Apoptosis of Human Umbilical Vein Endothelial Cells Through Regulating High-Mobility Group Box-1 in Henoch-Schonlein Purpura.

Am J Med Sci 2018 Jul 5;356(1):64-71. Epub 2018 Apr 5.

Department of Pediatrics, Inner Mongolia People's Hospital, Huhhot, Inner Mongolia, China.

Background: Apoptosis of human umbilical vein endothelial cells (HUVECs) plays an important role in the progression of Henoch-Schonlein purpura (HSP). In the present study, we explored the function of miR-218-5p in HUVEC apoptosis and HSP development.

Materials And Methods: HSP rat model was established and peripheral blood mononuclear cells (PBMC) were isolated. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.04.001DOI Listing
July 2018
9 Reads

Henoch-Schönlein purpura with acute pancreatitis: analysis of 13 cases.

BMC Pediatr 2018 05 11;18(1):159. Epub 2018 May 11.

Department of Pediatrics, First Affiliated Hospital of Anhui Medical University, 19th Floor of Medicine and Medical Tech Building, 218 Jixi Road, Hefei, 230022, Anhui, China.

Background: Henoch-Schönlein purpura is a common small vessel vasculitis in children. Acute pancreatitis rarely presents as a complication of Henoch-Schönlein purpura and has not been well characterized.

Methods: We retrospectively reviewed 13 cases of Henoch-Schönlein purpura with acute pancreatitis among 3212 patients who attended our hospital between January 2003 and June 2016 and analyzed their clinical characteristics, laboratory findings, imaging findings, treatment and overall prognosis. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-018-1142-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948829PMC
May 2018
4 Reads

Hemorrhagic bullous lesions in Henoch-Schönlein purpura: a case report and review of the literature.

BMC Pediatr 2018 05 10;18(1):157. Epub 2018 May 10.

Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics, Kaohsiung Veterans General Hospital, No. 386, Dazhong 1st Road, Zuoying District, Kaohsiung City, 813, Taiwan.

Background: Henoch-Schönlein purpura (HSP) is a common vasculitis in childhood characterized by purpura, arthritis, abdominal pain and renal involvement. However, bullous HSP is a rare cutaneous manifestation, and a few cases have been reported.

Case Presentation: Herein, we report a 15-year-old male with bullous HSP who presented with severe abdominal pain and hemorrhagic bullous lesions over his lower extremities. Read More

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http://dx.doi.org/10.1186/s12887-018-1117-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944150PMC
May 2018
4 Reads

Incidence and risk factors for recurrent Henoch-Schönlein purpura in children from a 16-year nationwide database.

Pediatr Rheumatol Online J 2018 Apr 16;16(1):25. Epub 2018 Apr 16.

Department of Medicine, Mackay Medical College, No.45, Minsheng Rd., Tamsui Dist., New Taipei City, 25160, Taiwan.

Background: The recurrence rate of Henoch-Schönlein purpura (HSP) is 2.7%-30%, with varied average intervals between the first and second episodes. Few studies have explored the incidence and risk factors for recurrent HSP. Read More

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http://dx.doi.org/10.1186/s12969-018-0247-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902957PMC
April 2018
16 Reads

Urinary fibrin/fibrinogen degradation products measured using an anti-fibrinogen antibody predict orthostatic proteinuria.

Pediatr Int 2018 Jul;60(7):639-644

Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.

Background: The aim of this study was to assess the diagnostic value of urinary fibrin/fibrinogen degradation products (uFDP) measured using an anti-fibrinogen antibody in patients with orthostatic proteinuria (OP), and their use in differentiating between OP and glomerulonephritis (GN).

Methods: uFDP were measured using first urine in the morning (supine) and non-first urine during a hospital visit (upright) and then normalized to urine creatinine (uFDP/Cr, ng/mgCr). We compared (i) OP patients (n = 16); (ii) those in remission from nephrotic syndrome (NS, n = 14) and from GN (IgA nephropathy [IgAN], n = 14; Henoch-Schönlein purpura nephritis [HSPN], n = 12); and (iii) those with active GN (IgAN, n = 12; HSPN, n = 19). Read More

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http://dx.doi.org/10.1111/ped.13576DOI Listing
July 2018
6 Reads

Henoch Schönlein Purpura Nephritis Developing in a Child with Known IgA Nephropathy.

Indian J Pediatr 2018 09 6;85(9):808-809. Epub 2018 Apr 6.

Fortis Institute of Renal Transplantation Sciences, Fortis Hospital, Vasant Kunj, New Delhi, India.

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http://dx.doi.org/10.1007/s12098-018-2660-xDOI Listing
September 2018
11 Reads
0.920 Impact Factor

Colonoscopic diagnosis and reduction of recurrent intussusception owing to Henoch-Schönlein purpura without purpura.

Paediatr Int Child Health 2018 Apr 6:1-5. Epub 2018 Apr 6.

a Departments of Pediatrics , Kawaguchi Municipal Medical Center , Saitama , Japan.

About 50-75% of patients with Henoch-Schönlein purpura (HSP) develop gastro-intestinal symptoms with surgical complications such as intussusception occurring in 0.7-13.6%. Read More

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http://dx.doi.org/10.1080/20469047.2018.1457273DOI Listing
April 2018
5 Reads