2,592 results match your criteria Pediatrics Headache


Symptom profiles and postural control after concussion in female artistic athletes.

Brain Inj 2020 May 22:1-6. Epub 2020 May 22.

Department of Orthopedics, University of Colorado School of Medicine , Aurora, CO, USA.

Objectives: The purpose of our investigation was to compare post-concussion symptom profiles and postural control measures among female youth artistic athletes (gymnasts and cheerleaders) relative to female ball sport athletes (volleyball or basketball).

Methods/findings: We compared 27 artistic athletes (median age = 15.0 years; evaluated median = 13 days post-injury) and 49 ball sport athletes (median age = 15. Read More

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http://dx.doi.org/10.1080/02699052.2020.1763464DOI Listing

[Vasovagal syncope or postural orthostatic tachycardia syndrome in children with neurological symptoms at disease onset: a clinical analysis of 88 cases].

Zhongguo Dang Dai Er Ke Za Zhi 2020 May;22(5):488-493

Department of Pediatrics, Second Xiangya Hospital of Central South University, Changsha 410011, China.

Objective: To study the clinical features of vasovagal syncope (VVS) and postural orthostatic tachycardia syndrome (POTS) in children with neurological symptoms at disease onset.

Methods: A retrospective analysis was performed on the medical data of 88 children with the initial symptoms of the nervous system, such as transient loss of consciousness, dizziness, headache, and convulsion, who were finally diagnosed with VVS or POTS.

Results: Of the 88 children, there were 35 boys (40%) and 53 girls (60%), with an age of 4-15 years. Read More

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Diagnostic and therapeutic aspects of hemiplegic migraine.

J Neurol Neurosurg Psychiatry 2020 May 19. Epub 2020 May 19.

Dipartimento di Neuroscienze Salute Mentale e Organi di Senso (NESMOS), University of Rome La Sapienza Faculty of Medicine and Psychology, Roma, Lazio, Italy

Hemiplegic migraine (HM) is a clinically and genetically heterogeneous condition with attacks of headache and motor weakness which may be associated with impaired consciousness, cerebellar ataxia and intellectual disability. Motor symptoms usually last <72 hours and are associated with visual or sensory manifestations, speech impairment or brainstem aura. HM can occur as a sporadic HM or familiar HM with an autosomal dominant mode of inheritance. Read More

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http://dx.doi.org/10.1136/jnnp-2020-322850DOI Listing

Antimicrobial sensitivity profile and bacterial isolates among suspected pyogenic meningitis patients attending at Hawassa University Hospital: Cross-sectional study.

BMC Microbiol 2020 May 19;20(1):125. Epub 2020 May 19.

Department of Neurology, Hawassa University College of Medicine and Health Sciences, Hawassa, Ethiopia.

Background: Bacterial meningitis is a serious inflammation of the meninges. Antimicrobial therapy on early cerebrospinal fluid (CSF) examination has an important role in diagnosis. The disease is still challenging in developing countries because of poor (diagnostic set-up, socioeconomic conditions, management), and misuse of antimicrobial therapy results in emerging antimicrobial-resistant strains. Read More

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http://dx.doi.org/10.1186/s12866-020-01808-5DOI Listing

Too Much of a Good Thing? Cerebral Sinovenous Thrombosis Due to Excessive Milk Intake Associated Anemia.

J Child Neurol 2020 May 19:883073820923807. Epub 2020 May 19.

Division of Child Neurology, Department of Neurology, Medical College of Wisconsin, Children's Wisconsin, Milwaukee, WI, USA.

Introduction: In young children, excessive cow's milk intake causes iron-deficiency anemia, which is associated with hypercoagulable states. We present a case series of 4 toddlers with excessive milk intake iron-deficiency anemia and cerebral sinovenous thrombosis.

Methods: Retrospective chart review of 4 patients was performed for patients with cerebral sinovenous thrombosis and iron-deficiency anemia secondary to excessive milk intake. Read More

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http://dx.doi.org/10.1177/0883073820923807DOI Listing

NMDAR Encephalitis Associated With Acute Chikungunya Virus Infection: A New Trigger?

Front Pediatr 2020 30;8:176. Epub 2020 Apr 30.

Faculdade Israelita de Ciências da Saúde Albert Einstein, São Paulo, Brazil.

Anti-NMDAR encephalitis is the most frequent cause of autoimmune encephalitis. Chikungunya (CHIK) is an arbovirus responsible for outbreaks of fever, cutaneous rash and arthritis in underdeveloped countries, and a trigger for autoimmunity. We report a five-year-old male patient with fever, myalgia, headache and conjunctivitis for 5 days. Read More

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http://dx.doi.org/10.3389/fped.2020.00176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204150PMC

Evaluation and Treatment of Primary Headaches in Adolescents.

Prim Care 2020 Jun 20;47(2):241-256. Epub 2020 Feb 20.

Department of Emergency Medicine, WVU Medicine, West Virginia University, 1 Medical Center Drive, Morgantown, WV, 26505, USA.

Headache is a common episodic and chronic pain syndrome in adolescents. Evaluation of headaches in primary care requires a comprehensive assessment including lifestyle behaviors and physical examination, as well as an understanding of when to pursue appropriate testing. Primary headache disorders seen in adolescents include migraine and tension-type headache. Read More

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http://dx.doi.org/10.1016/j.pop.2020.02.004DOI Listing

Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infants.

Cochrane Database Syst Rev 2020 May 18;5:CD011505. Epub 2020 May 18.

C/O Department of Paediatrics, RCSI & UCD Malaysia Campus (formerly Penang Medical College), George Town, Malaysia.

Background: Many women express concern about their ability to produce enough milk, and insufficient milk is frequently cited as the reason for supplementation and early termination of breastfeeding. When addressing this concern, it is important first to consider the influence of maternal and neonatal health, infant suck, proper latch, and feeding frequency on milk production, and that steps be taken to correct or compensate for any contributing issues. Oral galactagogues are substances that stimulate milk production. Read More

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http://dx.doi.org/10.1002/14651858.CD011505.pub2DOI Listing

ED and Inpatient Management of Headache in Children and Adolescents.

Curr Neurol Neurosci Rep 2020 May 14;20(6):15. Epub 2020 May 14.

Department of Pediatrics (Neurology), University of Colorado School of Medicine and Children's Hospital of Colorado, 13123 E. 16th Ave, B155, Aurora, CO, 80045, USA.

Purpose Of Review: Pediatric migraine is common, and appropriate abortive treatment is important to limit impact on school performance and mental health. This review will describe the latest evidence for abortive treatment in the emergency department and inpatient settings.

Recent Findings: It is recognized that a protocol for emergency department treatment can increase efficacy and prevent admissions. Read More

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http://dx.doi.org/10.1007/s11910-020-01035-5DOI Listing

Patient characteristics of suspected mast-cell activation syndrome with sinonasal obstruction: a single institution experience.

Int Forum Allergy Rhinol 2020 May 14. Epub 2020 May 14.

Rick and Tina Caruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA.

Background: Mast-cell activation syndrome (MCAS) is increasingly recognized. Sinonasal obstruction is common among these patients. There is a paucity of literature describing the characteristics of MCAS and treatment outcomes. Read More

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http://dx.doi.org/10.1002/alr.22558DOI Listing

Fatal Eosinophilic Myocarditis in a Healthy 17-Year-Old Male with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2c).

Fetal Pediatr Pathol 2020 May 13:1-6. Epub 2020 May 13.

Department of Pediatrics, Children's Hospital of New Orleans, New Orleans, Louisiana, USA.

Cardiac damage is frequently referred to in patients with SARS-CoV-2, is usually diagnosed by enzyme elevations, and is generally thought to be due to underlying coronary artery disease. There are references to cardiomyopathies accompanying coronavirus, but there has been no histologic confirmation. A previously healthy 17 year male old presented in full cardiac arrest to the emergency department after a 2 day history of headache, dizziness, nausea and vomiting. Read More

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http://dx.doi.org/10.1080/15513815.2020.1761491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232882PMC

Trametinib-based Treatment of Pediatric CNS Tumors: A Single Institutional Experience.

J Pediatr Hematol Oncol 2020 May 8. Epub 2020 May 8.

Department of Neurosciences, University of California and Rady Children's Hospital.

MEK inhibitors are an emerging therapy with increasing use in mitogen-activated protein kinase-driven central nervous system (CNS) tumors. There is limited data regarding efficacy and toxicity in pediatric patients. We report our clinical experience with trametinib-based therapy for the treatment of 14 consecutive pediatric patients with recurrent low-grade glioma (N=11) or high-grade CNS tumors (N=3) with MAP kinase pathway mutations. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001819DOI Listing

COVID-19 in Children, Pregnancy and Neonates: A Review of Epidemiologic and Clinical Features.

Pediatr Infect Dis J 2020 06;39(6):469-477

Department of Paediatrics, The University of Melbourne, Parkville, Australia.

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has spread rapidly across the globe. In contrast to initial reports, recent studies suggest that children are just as likely as adults to become infected with the virus but have fewer symptoms and less severe disease. In this review, we summarize the epidemiologic and clinical features of children infected with SARS-CoV-2 reported in pediatric case series to date. Read More

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http://dx.doi.org/10.1097/INF.0000000000002700DOI Listing

PREVALENCE AND OUTCOME OF LASSA FEVER AMONG HOSPITALIZED PATIENTS IN EBONYI STATE, NIGERIA, 2018 - 2019.

Virus Res 2020 May 4:198000. Epub 2020 May 4.

Department of Applied Microbiology, Faculty of Science, Ebonyi State University, P.M.B. 053, Abakaliki, Ebonyi State, Nigeria.

Lassa fever (LF) is a viral hemorrhagic illness endemic in West Africa. Annually, about 300,000 - 500,000 people are being infected, with about 5,000 deaths. Symptoms of LF include high grade fever, headache, malaise, abdominal pain, vomiting, diarrhea, or sore throat. Read More

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http://dx.doi.org/10.1016/j.virusres.2020.198000DOI Listing

Nonspecific Symptoms in Children Referred to a Lyme Borreliosis Center.

Pediatr Infect Dis J 2020 May 1. Epub 2020 May 1.

From the Lyme Center Apeldoorn.

Background: Nonspecific symptoms in children suspected of Lyme borreliosis (LB) are challenging for clinicians. We assessed whether nonspecific symptoms are more prevalent among children with positive immunoglobulin G (IgG) serology or a history of clinical LB.

Methods: We included children (<18 years) suspected of LB who visited the Lyme Center Apeldoorn of Gelre Hospital between 2008 and 2017. Read More

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http://dx.doi.org/10.1097/INF.0000000000002675DOI Listing

Sensory processing patterns affect headache severity among adolescents with migraine.

J Headache Pain 2020 May 6;21(1):48. Epub 2020 May 6.

Occupational Therapy Department, University of Haifa, Haifa, Israel.

Objective: To evaluate the relationship between pain catastrophizing level, sensory processing patterns, and headache severity among adolescents with episodic migraine.

Background: Catastrophizing about pain is a critical variable in how we understand adjustment to pain and has a unique contribution in predicting pain intensity. Recent reports found that migraine is also related to enhanced sensory sensitivity. Read More

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http://dx.doi.org/10.1186/s10194-020-01119-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203579PMC

ACR Appropriateness Criteria® Cerebrovascular Disease-Child.

J Am Coll Radiol 2020 May;17(5S):S36-S54

Specialty Chair, Riley Hospital for Children Indiana University, Indianapolis, Indiana.

Stroke is an uncommon but an important and under-recognized cause of morbidity and mortality in children. Strokes may be due to either brain ischemia or intracranial hemorrhage. Common symptoms of pediatric acute stroke include headache, vomiting, focal weakness, numbness, visual disturbance, seizures, and altered consciousness. Read More

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http://dx.doi.org/10.1016/j.jacr.2020.01.036DOI Listing

Dural based primary central nervous system lymphoma with bone invasion: a case report.

World Neurosurg 2020 Apr 30. Epub 2020 Apr 30.

Department of Neurosurgery, and Pathology.

Primary central nervous system lymphoma (PCNSL) occurs frequently in a deep intraparenchymal location. It rarely occurs in the meninges, and bone invasion is uncommon. A 12-year-old boy was admitted to our hospital with a history of headache and seizures. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.164DOI Listing

Clinical and imaging features of children with autoimmune encephalitis and MOG antibodies.

Neurol Neuroimmunol Neuroinflamm 2020 Jul 1;7(4). Epub 2020 May 1.

From the Department of Radiology (A.W.-P., R.C.), Children's Hospital Datteln, University Witten/Herdecke; Department of Pediatrics (E.-M.W.), Olgahospital, Klinikum Stuttgart, Germany; Division of Pediatric Neurology (M. Baumann, C.L.), Department of Pediatrics I, Medical University of Innsbruck, Austria; Department of Pediatric Neurology (A.B., K.R.), Children's Hospital Datteln, University Witten/Herdecke; Department of Pediatrics (M.H.), Division of Neuropediatrics and Social Pediatrics, Medical University RWTH Aachen, Germany; Charité-Universitätsmedizin Berlin (E.K.), Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Germany; Department of Neuropediatrics (E.K.), Berlin, Germany; Department of Pediatrics and Adolescent Medicine (E.R.-F., M. Breu), Medical University of Vienna; St. Anna Children´s Hospital (E.R.-F.), Vienna, Austria; Klinik für Kinder und Jugendmedizin (Ö.S.), Evangelisches Krankenhaus Hamm, Germany; Department of Neuropediatrics (A.D.M.), Developmental Neurology and Social Pediatrics, Children's Hospital, University of Duisburg-Essen, Germany; Department of Pediatrics (R.P.), Christliches Kinderhospital Osnabrück, Germany; Department of Pediatric Neurology (M.P.), Children's Hospital Auf der Bult, Hannover Germany; Department of Neonatology (C.R.), Pediatric Intensive Care, Sleep Medicine, Children's Hospital Datteln, University Witten/Herdecke, Germany; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Neuroimmunology (F.L.), Institute of Clinical Chemistry and Department of Neurology, Christian-Albrechts-University Kiel and Medical University Hospital Schleswig-Holstein, Germany; and Clinical Department of Neurology (M.R.), Medical University of Innsbruck, Austria.

Objective: To describe the presentations, radiologic features, and outcomes of children with autoimmune encephalitis associated with myelin oligodendrocyte glycoprotein antibodies (MOG abs).

Methods: Identification of children fulfilling the diagnostic criteria for possible autoimmune encephalitis (AE) and testing positive for serum MOG abs. Chart review and comprehensive analysis of serum MOG abs using live cell assays and rat brain immunohistochemistry. Read More

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http://dx.doi.org/10.1212/NXI.0000000000000731DOI Listing

Pediatric Post-Traumatic Headache and Implications for Return to Sport: A Narrative Review.

Headache 2020 May 1. Epub 2020 May 1.

Department of Neurology, Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA.

Background: Headache attributed to mild traumatic injury of the head (aka: mild traumatic brain injury, mTBI), frequently abbreviated to Post-Traumatic Headache (PTH), is one of the most common and disabling symptoms after a head injury. PTH often phenotypes to migraine. Evidence for treating PTH in the pediatric population is limited. Read More

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http://dx.doi.org/10.1111/head.13824DOI Listing

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease.

Nat Genet 2020 May 27;52(5):482-493. Epub 2020 Apr 27.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Read More

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http://dx.doi.org/10.1038/s41588-020-0610-9DOI Listing
May 2020
29.352 Impact Factor

Effectiveness of low-dose riboflavin as a prophylactic agent in pediatric migraine.

Brain Dev 2020 Apr 23. Epub 2020 Apr 23.

Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo, Japan.

Background: Riboflavin may prevent migraine episodes; however, there is limited evidence of its effectiveness in pediatric populations. This study investigated the effectiveness of riboflavin and clinical predictors of response in children with migraines.

Methods: We retrospectively reviewed data from 68 Japanese children with migraines, of whom 52 also exhibited another type of headache. Read More

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http://dx.doi.org/10.1016/j.braindev.2020.04.002DOI Listing

A systematic review of surgical treatments of idiopathic intracranial hypertension (IIH).

Neurosurg Rev 2020 Apr 25. Epub 2020 Apr 25.

Department of Neurological Surgery, New York Presbyterian Hospital/Weill Cornell Medical Center, New York, NY, USA.

Idiopathic intracranial hypertension denotes raised intracranial pressure in the absence of an identifiable cause and presents with symptoms relating to elevated ICP, namely headaches and visual deterioration. Treatment of IIH aims at reducing intracranial pressure, relieving headache and salvaging patients' vision. Surgical interventions are recommended for medically refractory IIH and include CSF diversion techniques, optic nerve sheath fenestration, bariatric surgery and venous sinus stenting. Read More

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http://dx.doi.org/10.1007/s10143-020-01288-1DOI Listing

Factors associated with negative conversion of viral RNA in patients hospitalized with COVID-19.

Sci Total Environ 2020 Apr 22;728:138812. Epub 2020 Apr 22.

Municipal Centre of Disease Control and Prevention of Qingdao, Qingdao Institute of Prevention Medicine, Qingdao, Shandong Province, China. Electronic address:

Factors associated with negative conversion of SARS-CoV-2 RNA in hospitalized patients have not yet been systematically determined. We conducted a retrospective cohort study of COVID-19 patients in Qingdao, China. Both univariate and multivariate analysis were performed to identify independent factors for time to viral RNA negative conversion. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.138812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175870PMC

Alterations in Brain Function After Cognitive Behavioral Therapy for Migraine in Children and Adolescents.

Headache 2020 Apr 23. Epub 2020 Apr 23.

Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Objectives: This basic mechanistic study examined the changes in brain activation and resting-state connectivity after 8 weeks of CBT in youth with migraine.

Background: Cognitive behavioral therapy (CBT) is a psychological intervention that is effective in reducing pain in migraine patients. However, the neural mechanisms underlying CBT in adolescents with migraine are not yet known. Read More

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http://dx.doi.org/10.1111/head.13814DOI Listing

Digital Therapeutic Self-Management Intervention in Adolescents With Migraine: Feasibility and Preliminary Efficacy of "Migraine Manager".

Headache 2020 Apr 22. Epub 2020 Apr 22.

Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Objective: The objective of this study was to design, code, and pilot test the feasibility and preliminary efficacy of a self-management digital therapeutic tool for adolescents with migraine.

Background: Self-management of migraine in adolescents is complex and has important implications for health outcomes. A comprehensive and accessible approach to self-management is needed for youth with migraine, their parents, and clinicians. Read More

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http://dx.doi.org/10.1111/head.13805DOI Listing

Development of a pediatric Lyme meningitis symptom measurement instrument using a Delphi technique.

Ticks Tick Borne Dis 2020 Mar 23:101418. Epub 2020 Mar 23.

Division of Emergency Medicine, Harvard Medical School; Boston, MA and Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, USA.

Published Lyme meningitis treatment studies are limited by outcome measures that cannot capture day-to-day differences in clinical improvement. Our goal was to use expert consensus to develop a daily measurement instrument for assessing clinical improvement in children with Lyme meningitis. We assembled a panel of 24 nationally recognized Lyme disease experts to develop a pediatric daily symptom measurement instrument. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2020.101418DOI Listing

Very late recurrence of B-cell acute lymphoblastic leukemia masquerading as a pituitary tumor.

Pediatr Hematol Oncol 2020 Apr 16:1-7. Epub 2020 Apr 16.

Aflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.

Involvement of the pituitary gland by leukemic infiltration is exceedingly rare. Here, we describe a very late recurrence of B-cell acute lymphoblastic leukemia masquerading as a pituitary tumor and review the literature for previously reported cases. Our female patient presented 13 years after completion of therapy for B-ALL with headache, amenorrhea, galactorrhea and a pituitary mass. Read More

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http://dx.doi.org/10.1080/08880018.2020.1751754DOI Listing

Safety and tolerability of transcranial magnetic and direct current stimulation in children: Prospective single center evidence from 3.5 million stimulations.

Brain Stimul 2020 May - Jun;13(3):565-575. Epub 2019 Dec 30.

Calgary Pediatric Stroke Program, University of Calgary, Calgary, Alberta, Canada; Departments of Pediatrics and Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada; Department of Neurosciences, University of Calgary, Calgary, Alberta, Canada; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: Non-invasive brain stimulation is being increasingly used to interrogate neurophysiology and modulate brain function. Despite the high scientific and therapeutic potential of non-invasive brain stimulation, experience in the developing brain has been limited.

Objective: To determine the safety and tolerability of non-invasive neurostimulation in children across diverse modalities of stimulation and pediatric populations. Read More

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http://dx.doi.org/10.1016/j.brs.2019.12.025DOI Listing
December 2019

Gender equality and global health: intersecting political challenges.

J Glob Health 2020 Jun;10(1):010701

Department of Pediatrics and Center for Population Health Sciences, Stanford University School of Medicine, Stanford, California, USA.

Background: Women's and men's health outcomes are different. Some differences are biological, related to male and female sex, while others are related to their gender. Sex- and gender-related issues require different solutions, but policy makers lack straightforward heuristic strategies to identify gender-related health inequities. Read More

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http://dx.doi.org/10.7189/jogh.10.010701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101083PMC

Periodic syndrome associated with the mutation of the receptor gene of the tumor necrosis factor (clinical case).

Wiad Lek 2020 ;73(2):405-409

Medical Biology and Genetics Department, Higher State Educational Establishment of Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine.

The paper deals with a case of TRAPS in a Ukrainian family. The manifestations of this syndrome appeared at the age of 2,5 years and gradually the attacks of fever became morefrequent and the recurrence was typical of this diagnosis. Classically, besides fever, there was an intense abdominal pain, such as an "acute abdomen", arthralgia in the right hip and headache. Read More

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A correlation analysis between clinical manifestations, therapeutic strategies, and the prognosis of children with cryptococcal meningitis in China.

Int J Infect Dis 2020 Mar 31;95:241-245. Epub 2020 Mar 31.

Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; Hunan Intellectual and Developmental Disabilities Research Center of Children, Changsha 410008, Hunan, China. Electronic address:

Objective: This aim of this study was to analyze the correlations between clinical manifestations, treatment strategies, and the prognosis in cryptococcal meningitis (CM) in China.

Methods: This was a retrospective analysis of the clinical data of CM patients treated during the years 2002-2019. The clinical features and supplementary examinations, treatment strategies, and prognosis were summarized and then a correlation analysis was performed. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.03.068DOI Listing

A case report of empty Sella syndrome secondary to Hantaan virus infection and review of the literature.

Medicine (Baltimore) 2020 Apr;99(14):e19734

Department of Infectious Diseases, The First Hospital, Jilin University, Changchun, Jilin, China.

Rationale: Bleeding in the anterior pituitary lobe leading to tissue necrosis occurs in the acute stage of severe clinical forms of hemorrhagic fever with renal syndrome (HFRS), while atrophy of the anterior pituitary lobe with diminution of the gland function occurs after the recovery stage. The relationship between Hantaan virus infection and empty Sella syndrome (ESS) has rarely been reported.

Patient Concerns: This patient was a 54-year-old previously healthy Chinese male. Read More

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http://dx.doi.org/10.1097/MD.0000000000019734DOI Listing

Migraine Care in the Era of COVID-19: Clinical Pearls and Plea to Insurers.

Headache 2020 05 3;60(5):833-842. Epub 2020 Apr 3.

Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, VA, USA.

Objective: To outline strategies for the treatment of migraine which do not require in-person visits to clinic or the emergency department, and to describe ways that health insurance companies can remove barriers to quality care for migraine.

Background: COVID-19 is a global pandemic causing widespread infections and death. To control the spread of infection we are called to observe "social distancing" and we have been asked to postpone any procedures which are not essential. Read More

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http://dx.doi.org/10.1111/head.13810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228371PMC

Young Girl With Headache.

Ann Emerg Med 2020 04;75(4):e21-e22

Division of Emergency Medicine, Boston Children's Hospital, Boston, MA.

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http://dx.doi.org/10.1016/j.annemergmed.2019.10.023DOI Listing

Decadron, Diamox, and Zantac: A Novel Combination for Ventricular Shunt Failure in Pediatric Neurosurgical Patients.

Pediatr Emerg Care 2020 Mar 12. Epub 2020 Mar 12.

Division of Emergency Medicine and Department of Pediatrics, Children's Hospital of Philadelphia.

Objective: Cerebral ventricular shunt failure is common and presents with symptoms that range from headaches to death. The combination of Diamox (acetazolamide), Decadron (dexamethasone), and Zantac (ranitidine) (DDZ) is used at our institution to medically stabilize pediatric patients presenting with symptomatic shunt failure before shunt revision. We describe our experience of this drug combination as a temporizing measure to decrease symptoms associated with shunt failure. Read More

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http://dx.doi.org/10.1097/PEC.0000000000002070DOI Listing

Republished: A lumbar arteriovenous fistula presenting with intraventricular hemorrhage and hydrocephalus.

J Neurointerv Surg 2020 May 17;12(5):e5. Epub 2020 Mar 17.

Department of Radiology, University of Kentucky, Lexington, Kentucky, USA.

Pediatric spinal vascular malformations are rare entities that typically present with symptoms from their effect on surrounding structures. Here we report a unique case of lumbar spinal dural/perimedullary arteriovenous fistula (AVF) that presented with intraventricular hemorrhage and hydrocephalus. The previously healthy child presented with lethargy and headache, and initial imaging revealed only ventriculomegaly with trace intraventricular blood. Read More

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http://dx.doi.org/10.1136/neurintsurg-2019-015631.repDOI Listing

Use of Eltrombopag in Children With Chronic Immune Thrombocytopenia (ITP): A Real Life Retrospective Multicenter Experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP).

Front Med (Lausanne) 2020 28;7:66. Epub 2020 Feb 28.

Pediatric Unit, Department of Biomedical Science and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.

The thrombopoietin receptor agonist eltrombopag has been shown to be safe and effective for children with chronic immune thrombocytopenia (ITP). The aim of the present study was to characterize eltrombopag use in current clinical practice. This is a retrospective multicenter study conducted in 17 centers affiliated to the Italian Association of Pediatric Hematology and Oncology (AIEOP). Read More

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http://dx.doi.org/10.3389/fmed.2020.00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059456PMC
February 2020

Epidemiology, clinical and laboratory findings of leptospirosis in Southwestern Greece.

Infect Dis (Lond) 2020 Jun 17;52(6):413-418. Epub 2020 Mar 17.

Department of Internal Medicine, Division of Infectious Diseases, University Hospital of Patras, Patras, Greece.

Leptospirosis is a zoonosis with global distribution. The aim of the present study was to determine epidemiological, clinical and laboratory characteristics of leptospirosis in Greece. We retrospectively reviewed the clinical and laboratory profile as well as the outcome of all adults with confirmed leptospirosis in our Tertiary Referral centre in Southwestern Greece from 2013 to 2017. Read More

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http://dx.doi.org/10.1080/23744235.2020.1739745DOI Listing

The safety of combined triple drug therapy with ivermectin, diethylcarbamazine and albendazole in the neglected tropical diseases co-endemic setting of Fiji: A cluster randomised trial.

PLoS Negl Trop Dis 2020 03 16;14(3):e0008106. Epub 2020 Mar 16.

Tropical Diseases Research Group, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.

Lymphatic filariasis has remained endemic in Fiji despite repeated mass drug administration using the well-established and safe combination of diethylcarbamazine and albendazole (DA) since 2002. In certain settings the addition of ivermectin to this combination (IDA) remains a safe strategy and is more efficacious. However, the safety has yet to be described in scabies and soil-transmitted helminth endemic settings like Fiji. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098623PMC

Cervical Noninvasive Vagus Nerve Stimulation for Migraine and Cluster Headache: A Systematic Review and Meta-Analysis.

Neuromodulation 2020 Mar 12. Epub 2020 Mar 12.

Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Background: Noninvasive vagus nerve stimulation (nVNS) has been proposed as a new neuromodulation therapy to treat primary headache disorders. The purpose of this study was to analyze the effectiveness and safety of peripheral nerve stimulation of the cervical branch of the vagal nerve for primary headache disorders.

Methods: A systematic review and meta-analysis of the literature was carried out on randomized controlled trials of nVNS for treating headaches. Read More

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http://dx.doi.org/10.1111/ner.13122DOI Listing
March 2020
1.785 Impact Factor

Motion sickness: an overview.

Drugs Context 2019 13;8. Epub 2019 Dec 13.

Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.

Background: Motion sickness is a common phenomenon that affects almost everybody at some point in their lifetime. Clinicians should be familiar with the proper management of this condition.

Objective: To provide an update on the current understanding of the pathophysiology and management of motion sickness. Read More

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http://dx.doi.org/10.7573/dic.2019-9-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048153PMC
December 2019

Feasibility of a Nonmydriatic Ocular Fundus Camera in an Outpatient Neurology Clinic.

Neurologist 2020 Mar;25(2):19-23

Ophthalmology and Neurology, Emory University, Atlanta, GA.

Objective: To determine the feasibility of nonmydriatic fundus photography in the neurology outpatient setting and to record frequency of clinically relevant fundus findings.

Methods: Over 5 weeks, fundus photographs were obtained using a nonmydriatic fundus camera in both eyes of adult patients attending our general neurology and headache clinics. A neurologist, who had received 15 minutes of training on the use of the camera, took the photographs. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000259DOI Listing

Expanding Cyst of the Septum Pellucidum - Endoscopic Observations on the Mechanism of Development and Results of Treatment.

Neurol Med Chir (Tokyo) 2020 Apr 5;60(4):202-208. Epub 2020 Mar 5.

Department of Pediatrics, Endocrinology, Cardiology and Metabolic Diseases, Pomeranian Medical University in Szczecin.

Cysts of the septum pellucidum (CSP) are usually asymptomatic; however, in some cases they can begin expanding and cause neurological deterioration. The mechanism leading to the formation of an expanding cyst of the septum pellucidum (ECSP) is not known. Based on observations made during endoscopic treatment of ECSP we analyzed intraoperative findings in respect to cyst formation mechanism and treatment prognosis. Read More

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http://dx.doi.org/10.2176/nmc.oa.2019-0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174244PMC

A lumbar arteriovenous fistula presenting with intraventricular hemorrhage and hydrocephalus.

BMJ Case Rep 2020 Mar 3;13(3). Epub 2020 Mar 3.

Department of Radiology, University of Kentucky, Lexington, Kentucky, USA.

Pediatric spinal vascular malformations are rare entities that typically present with symptoms from their effect on surrounding structures. Here we report a unique case of lumbar spinal dural/perimedullary arteriovenous fistula (AVF) that presented with intraventricular hemorrhage and hydrocephalus. The previously healthy child presented with lethargy and headache, and initial imaging revealed only ventriculomegaly with trace intraventricular blood. Read More

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http://dx.doi.org/10.1136/bcr-2019-015631DOI Listing

Correlation between the total number of features of paediatric pseudotumour cerebri syndrome and cerebrospinal fluid pressure.

Childs Nerv Syst 2020 Mar 2. Epub 2020 Mar 2.

Paediatric Neurology, Department of Paediatrics, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, CB2 0QQ, UK.

Purpose: Accurate diagnosis of pseudotumour cerebri syndrome (PTCS) in children is challenging. We aimed to see if the clinical and radiological assessment that is carried out before lumbar puncture could predict subsequently recorded CSF pressures, and thus whether it could be used to increase diagnostic certainty of paediatric PTCS.

Methods: We used internationally recognised diagnostic criteria to derive a list of clinical, brain neuroimaging and venography features that were accepted to be associated with a diagnosis of PTCS. Read More

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http://dx.doi.org/10.1007/s00381-020-04537-2DOI Listing

[Clinical analysis of 31 cases of 2019 novel coronavirus infection in children from six provinces (autonomous region) of northern China].

Zhonghua Er Ke Za Zhi 2020 Apr;58(4):269-274

Department of Pediatric Internal Medicine, Xi'an Children's Hospital, Xi'an 710003, China.

To analyze the epidemiological history, clinical manifestations, treatment and the short-term prognosis of 31 cases of 2019 novel coronavirus (2019-nCoV) infection in children from six provinces (autonomous region) in northern China. A retrospective analysis of the epidemiological history, clinical symptoms, signs, laboratory examinations, chest imaging, treatment and the short-term prognosis of 31 cases of 2019-nCoV was conducted. The patients were diagnosed between January 25th, 2020 and February 21st, 2020 in 21 hospitals in 17 cities of six provinces (autonomous region) of Shaanxi, Gansu, Ningxia, Hebei, Henan and Shandong. Read More

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http://dx.doi.org/10.3760/cma.j.cn112140-20200225-00138DOI Listing

Manifestation of migraine in adolescents: Does it change in puberty?

Eur J Paediatr Neurol 2020 Feb 20. Epub 2020 Feb 20.

Department of Pediatric Neurology, Children's Hospital Datteln, University of Witten Herdecke, Germany.

Purpose: To analyze the association between pubertal stage, menstrual cycle and migraine attacks in girls with migraine. In addition, headache frequency, accompanying symptoms, duration and onset in relation to the specific phase of the cycle were investigated.

Methods: Girls between 7 and 18 years old, diagnosed with headaches that met "International Classification of Headache Disorders II" diagnostic criteria for migraine without aura, kept a daily headache and menstrual cycle diary over 8 weeks. Read More

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http://dx.doi.org/10.1016/j.ejpn.2020.02.006DOI Listing
February 2020