Search Our Scientific Publications & Authors

Acta Biomed 2021 May 12;92(2):e2021242. Epub 2021 May 12.

Liaquat University of Medicine and Health Sciences, Jamshroo, Pakistan.

Brain Dev 2021 May 10. Epub 2021 May 10.

Department of Pediatrics, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Objective: This study aimed to investigate the associations between psychopathological characteristics of children and adolescents with primary headache, as measured by the Strengths and Difficulties Questionnaire (SDQ), and treatment outcomes.

Methods: A cohort study was conducted on 124 pediatric patients with primary headache. At the first consultation, the SDQ was completed by the parents. Read More

Cephalalgia 2021 May 13:3331024211014612. Epub 2021 May 13.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Adult abrupt severe non-traumatic headache (thunderclap) is often related to serious underlying etiologies such as subarachnoid hemorrhage. However, data are sparse regarding thunderclap headache in the pediatric population.

Objective: The aim of the study was to evaluate the prevalence, characteristics and causes of thunderclap headache in the pediatric and adolescent population, aged 6-18 years, presenting to a pediatric emergency department. Read More

Eur J Sport Sci 2021 May 12:1-36. Epub 2021 May 12.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.

Background: Acute Mountain Sickness (AMS) is a syndrome with nonspecific neurological symptoms that can occur in unacclimatized persons after Rapid Ascent to a High Altitude. Since Repeated Remote Ischaemic Preconditioning (RIPC) can protect remote organs from subsequent hypoxic or ischaemic damage, the aim of the present study was to assess the effectiveness of 4 different RIPC protocols varying in duration and frequency for preventing AMS after Rapid Ascent to a High Altitude.

Methods: We designed a prospective but not blinded study in which we randomly divided participants into five groups. Read More

Eur J Clin Microbiol Infect Dis 2021 May 11. Epub 2021 May 11.

Lyme Center Apeldoorn, Gelre Hospital, Apeldoorn, Netherlands.

We assessed the prevalence of Lyme neuroborreliosis in children with acute facial nerve palsy in a Lyme-endemic region and patient characteristics associated with this. All children visiting one of three participating hospitals between January 2010 and December 2016 were included in the study. Of 104 children referred to the hospital with facial nerve palsy, 43% had Lyme neuroborreliosis and 57% idiopathic facial palsy. Read More

Pain Rep 2021 1;6(1):e916. Epub 2021 Apr 1.

Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.

Introduction: The negative effects of chronic pain and obesity are compounded in those with both conditions. Despite this, little research has focused on the pathophysiology in pediatric samples.

Objective: To examine the effects of comorbid chronic pain and obesity on the concentration of circulating inflammatory biomarkers. Read More

J Korean Med Sci 2021 May 10;36(18):e132. Epub 2021 May 10.

Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea.

Background: Coronavirus disease 2019 (COVID-19) has spread around the globe, and it is important to determine the risk factors of death in the general population. Our study aimed to determine the risk factors of death and severe illness requiring supplemental oxygen therapy based on the demographic and clinical characteristics of COVID-19 patients in Korea.

Methods: In this study, we used data provided by the Korea Disease Control and Prevention Agency (KDCA) and analyzed a total of 5,068 patients with COVID-19, excluding 19 pregnant women and 544 individuals with missing data. Read More

Cureus 2021 May 6;13(5):e14868. Epub 2021 May 6.

Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Migraine is a common neurological disorder associated with or without aura. Although the pathophysiology of migraine is not very well understood, pro-inflammatory cytokines and oxidative stress biomarkers are found to be increased in migraine. Multiple studies have been done to see if alternative medicine such as herbal supplements and nutraceuticals are effective in the prevention and treatment of migraine headaches. Read More

Am J Trop Med Hyg 2021 May 10. Epub 2021 May 10.

2Department of Pediatrics, Hospital Universitario "Dr. José Eleuterio González," Universidad Autonoma de Nuevo León, Monterrey, Mexico.

Granulomatous amebic encephalitis (GAE) caused by Acanthamoeba is a rare infection with central nervous system (CNS) involvement usually with fatal consequences. Currently, information regarding GAE in children is scarce and is limited only to case reports and case series. A 13-year-old immunocompetent male patient with a 6-month history of progressive and intermittent headaches presented to our institution. Read More

Curr Neurol Neurosci Rep 2021 May 10;21(7):33. Epub 2021 May 10.

Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

Purpose Of Review: Headache affects and disables at least 1 billion people worldwide. Patients and providers seek new therapies to relieve headache without the side effects and financial burden of current treatments. This narrative review highlights recent treatment advances in integrative headache medicine: nutraceuticals and behavioral therapies. Read More

Eur J Paediatr Neurol 2021 Apr 30;32:122-127. Epub 2021 Apr 30.

Department of Paediatrics, Medical Centre Leeuwarden, P.O. Box 888, 8901, BR, Leeuwarden, the Netherlands. Electronic address:

Background: Hashimoto's encephalopathy, also known as steroid responsive encephalopathy, is associated with thyroid antibodies (SREAT) and is a rare but serious form of encephalopathy. In this paper, we describe the signs, symptoms, outcome, and treatments as noted in the case reports reviewed.

Methods: We searched PubMed, Embase, and the Cochrane library for articles in which cases of Hashimoto's encephalopathy were described. Read More

Front Hum Neurosci 2021 20;15:640574. Epub 2021 Apr 20.

Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy.

Despite that it is commonly accepted that migraine is a disorder of the nervous system with a prominent genetic basis, it is comorbid with a plethora of medical conditions. Several studies have found bidirectional comorbidity between migraine and different disorders including neurological, psychiatric, cardio- and cerebrovascular, gastrointestinal, metaboloendocrine, and immunological conditions. Each of these has its own genetic load and shares some common characteristics with migraine. Read More

BMC Infect Dis 2021 May 1;21(1):405. Epub 2021 May 1.

Key Laboratory for Pediatrics of Integrated Traditional and Western Medicine, Liaocheng People's Hospital, No. 67 Dongchang West Road, Liaocheng, 252000, Shandong Province, PR China.

Background: Aseptic meningitis is most often caused by enteroviruses (EVs), but EVs associated with aseptic meningitis have not yet been reported in Liaocheng. The aim of this study was to determine the prevalence and genetic characteristics of EVs causing aseptic meningitis in children in Liaocheng.

Methods: We reviewed the epidemiological and clinical characteristics of 504 paediatric cases of aseptic meningitis in Liaocheng from 2018 to 2019 and analysed the phylogeny of the predominant EV types causing this disease. Read More

Pediatr Rev 2021 May;42(5):258-261

Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL.

Behav Sci (Basel) 2021 Apr 14;11(4). Epub 2021 Apr 14.

Department of Life Sciences and Health, Faculty of Health Sciences, Oslo Metropolitan University, 0130 Oslo, Norway.

Migraine is one of the most prevalent headache disorders in children and negatively influences their quality of life. Physical, social, and school functioning are negatively affected. Mood changes are common in migraineurs and may happen before, during, or after a migraine headache. Read More

Indian J Ophthalmol 2021 05;69(5):1319-1321

Department of Ophthalmology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Multi Inflammatory Syndrome (MIS-C) associated with Corona Virus Disease (COVID) in children and young adults presents with a varied clinical spectrum; from that mimicking Kawasaki disease (KD), Incomplete Kawasaki disease to even Hemophagocytic Lymphohistiocytosis. A 14-year-old girl, presented to us, with headache, fever, bilateral uveitis, unilateral cervical lymphadenopathy, oral mucosal changes and abdominal pain. A disproportionate increase in inflammatory markers and Interleukin - 6, in the setting of a negative COVID real-time reverse transcription polymerase chain reaction (RTPCR) and significantly elevated COVID antibody titre confirmed our diagnosis. Read More

Ann Indian Acad Neurol 2021 Jan-Feb;24(1):8-10. Epub 2021 Feb 12.

Department of Pediatrics, Divisions of Pediatric Neurology and Genetics and Behavioral-Developmental Pediatrics, Necmettin Erbakan University, Meram Medical Faculty, Meram, Konya, Turkey.

Headache represents the most common neurologic disorder in the general population including children and is increasingly being recognized as a major source of morbidity in youth related to missed school days and activities. Electronic screens are becoming increasingly important in the lives of preteens and teens. In this review, we discussed effects of electronic screens on primary headache in childhood to emphasize the importance of electronic screen exposure in children with headache. Read More

J Pediatr Hematol Oncol 2021 Apr 26. Epub 2021 Apr 26.

Departments of Pharmacy Pediatrics, Peking University First Hospital Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China.

Background: Eculizumab is indicated for the treatment of paroxysmal nocturnal hemoglobinuria (PNH). This study aimed to evaluate the efficacy and safety of eculizumab in patients with PNH.

Methods: PubMed, EMBASE, The Cochrane Library, and ClinicalTrials. Read More

Pol Merkur Lekarski 2021 Apr;49(290):146-149

Department of Radiological Diagnostics and and Isotope Therapy, University Clinical Hospital of the Military Medical Academy - Central Veterans Hospital, Łódź, Poland.

Cerebral venous infarction also known as cerebral venous thrombosis (CVT) is a rare disease. It is more common in young adults, but three times more common in women than in men. The clinical picture of CVT may vary and non-specific manifestations often delay correct diagnosis. Read More

Headache 2021 Apr;61(4):565-566

Department of Neurology, University of Rochester, Rochester, NY, USA.

Headache 2021 Apr;61(4):563-564

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Ital J Pediatr 2021 Apr 21;47(1):98. Epub 2021 Apr 21.

Department of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II", Via S. Pansini, 5, 80131, Naples, Italy.

Background: Despite ibuprofen widely recognized safety profile, an increase of suspected adverse events has been reported in the last decade in parallel with its growing over-the-counter use. The aims of this study were to assess the therapeutic approach to the feverish child and to evaluate the main indications and the most frequent adverse events related to ibuprofen administration in children.

Methods: A specific questionnaire-form regarding the management of ibuprofen therapy in children was distributed among a sample of pediatricians all over the Italian territory between September and October 2020. Read More

J Child Neurol 2021 Apr 21:8830738211007699. Epub 2021 Apr 21.

2969Children's Hospital of MI, Detroit, MI, USA.

Background: Knowledge of the factors that predispose to postdural puncture headache in children may help reduce the occurrence of this complication.

Materials And Methods: A retrospective cohort study of children who presented to the study institution between 2010 and 2018 was conducted. Children were divided into 2 groups: those who experienced postdural puncture headache and those who did not. Read More

Mikrobiyol Bul 2021 Apr;55(2):180-193

Gaziosmanpasa University Faculty of Medicine, Department of Biostatistics, Tokat, Turkey.

Crimean-Congo hemorrhagic fever (CCHF) is endemic in Tokat province. It is observed in all age groups. The case fatality rate varies 20-30% in hospitalized patients and 0-5% among children. Read More

J Med Case Rep 2021 Apr 21;15(1):184. Epub 2021 Apr 21.

Department of Paediatrics, Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha, Maharashtra, 442001, India.

Introduction/background: Although central nervous system tumors are the most common etiology of malignancies in the pediatric age group, choroid plexus carcinomas are rare, with an annual incidence rate of 0.10 per 100,000 children.

Case Presentation: We report the case of an adolescent male belonging to central India who had presented with a history of persistent headache, projectile vomiting, neck stiffness, and an episode of generalized tonic-clonic seizure. Read More

Int J Infect Dis 2021 Apr 15;106:376-381. Epub 2021 Apr 15.

Internal Medicine, Temple University Hospital, Philadelphia, PA, USA.

Introduction: Concerns are prevailing about the safety and side effects of the BNT162b2 mRNA vaccine for coronavirus disease 2019 (COVID-19).

Methods: A randomized, cross-sectional study was performed to investigate the side effects of the BNT162b2 vaccine using an independent online questionnaire gathering responses from healthcare workers (HCWs) with detailed review of organ systems.

Results: Of all HCWs, 87. Read More

Indian J Med Microbiol 2021 Apr 12;39(2):245-248. Epub 2021 Apr 12.

Department of Centre for Integrative Medicine & Research, AIIMS, New Delhi, India. Electronic address:

Leptospirosis is considered as one of the most neglected zoonotic tropical diseases. Animals and humans acquire this infection through direct contact with contaminated urine or body fluids of infected animals. This prospective study was undertaken to know the proportion of leptospirosis in pediatric patients presented with acute febrile illness at the Post Graduate Department of Microbiology, King George's Medical University, Lucknow, Uttar Pradesh. Read More

Eur J Paediatr Neurol 2021 Apr 2;32:80-85. Epub 2021 Apr 2.

Pediatric Emergency Department, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. Electronic address:

Objectives: Acute strabismus (AS) is the most common ocular motility disorder in children. In the emergency setting evaluation, the primary concern is to exclude a potentially dangerous underlying condition, requiring immediate intervention. Our first aim was to describe the epidemiology, clinical features, and underlying causes of AS in a cohort of children presenting to the emergency department (ED). Read More

Pediatr Endocrinol Diabetes Metab 2021 Apr 15. Epub 2021 Apr 15.

Department of Pediatrics, University Hospital Farhat Hached, Sousse, Tunisia.

Pheochromocytoma is a rare tumor during childhood, originating from the chromafine tissue. The clinical presentation can be variable and assembling many other diseases. This tumor submits specific care problems. Read More

Pediatrics 2021 May 13;147(5). Epub 2021 Apr 13.

Department of Pediatrics, Rush Medical College, Rush University Medical Center, Chicago, Illinois.

A male individual aged 18 years with no significant past medical history presented with fever, headache, dry cough, and chest pain. On clinical examination, he had tachycardia and hypotension needing intravenous fluid resuscitation and inotropic support. A chest radiograph revealed streaky lung opacities, and he was treated with antibiotics for suspected community-acquired pneumonia complicated by septic shock. Read More