2,282 results match your criteria Pediatrics Headache


Scrofuloderma with disseminated tuberculosis in an Ethiopian child: a case report.

Authors:
Henok Tadele

J Med Case Rep 2018 Dec 17;12(1):371. Epub 2018 Dec 17.

Department of Pediatrics and Child Health, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Background: Cutaneous tuberculosis represents only 1-2% of extrapulmonary forms of tuberculosis. Scrofuloderma is an endogenous form of cutaneous tuberculosis and can present as isolated or coexist with pulmonary and disseminated forms of tuberculosis. Pathologically confirmed scrofuloderma coexisting with disseminated tuberculosis with a good treatment response is presented and discussed. Read More

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http://dx.doi.org/10.1186/s13256-018-1927-1DOI Listing
December 2018

Pediatric Integrative Medicine in Academia: Stanford Children's Experience.

Children (Basel) 2018 Dec 12;5(12). Epub 2018 Dec 12.

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, School of Medicine, Stanford University, Palo Alto, CA 94304, USA.

Pediatric integrative medicine is an emerging field which, to date, has not been described in detail in academic medical centers in the United States. Early research of pediatric integrative medicine modalities shows promise for the treatment of common pediatric conditions such as irritable bowel syndrome, acute and chronic pain, headache, and allergy, among others. In light of the growing prevalence of pediatric illnesses and patient complexity, it is crucial to emphasize the patient's overall well-being. Read More

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http://dx.doi.org/10.3390/children5120168DOI Listing
December 2018

Clival Chondroid Chordoma: A Case Report and Review of the Literature.

Cureus 2018 Sep 28;10(9):e3381. Epub 2018 Sep 28.

Department of Internal Medicine, Hospital Teodoro Maldonado Carbo / Universidad Catolica De Santiago De Guayaquil, Guayaquil, ECU.

Chordomas are rare, slow-growing, and locally aggressive malignant neoplasms derived from primitive notochord remnants. The chondroid variety represents 14% of all chordomas mainly developing in the spheno-occipital region and presenting between the third and fifth decades of life. When developing intracranially, symptoms can range from headaches and neck pain to cranial nerve neuropathies and facial numbness. Read More

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http://dx.doi.org/10.7759/cureus.3381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263615PMC
September 2018
1 Read

Lassa fever outbreak in adolescents in North Central Nigeria: report of cases.

J Virus Erad 2018 Oct 1;4(4):225-227. Epub 2018 Oct 1.

Department of Paediatrics, Jos university Teaching Hospital, Jos, Nigeria.

Background: Lassa fever (LF) is a viral haemorrhagic fever endemic to West Africa. The clinical presentation and course is variable, making diagnosis difficult.

Aim: To report the outbreak and identify the common clinical presentations of LF in paediatric patients in Jos, Plateau State, North Central, Nigeria. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248838PMC
October 2018
1 Read

T2-blackout effect on DWI as a sign of early bone infarct and sequestration in a patient with sickle cell disease.

Clin Imaging 2018 Nov 15;54:15-20. Epub 2018 Nov 15.

Department of Radiology, University of Florida, Gainesville, FL, United States of America.

Differentiation of bone infarct from osteomyelitis is one of the most challenging issues in the evaluation of acute bone pain in sickle cell patients. The imaging modalities that are currently being used for assessment of bone marrow in this population have several limitations. We present a case of an 18-year-old male with a history of sickle cell disease, who was transferred to our emergency department with progressively severe headache and jaw pain for one-week. Read More

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http://dx.doi.org/10.1016/j.clinimag.2018.11.006DOI Listing
November 2018
3 Reads

Posterior Reversible Encephalopathy Syndrome in a Patient with Variegate Porphyria: A Case Report.

Cureus 2018 Sep 24;10(9):e3351. Epub 2018 Sep 24.

Orthopaedics, Dow University of Health Sciences, Karachi, PAK.

Variegate porphyria (VP) is one of the groups of rare inherited disorders of hemoglobin synthesis called Porphyria. It has two distinct manifestations, that is, those of cutaneous and nervous system. Posterior reversible encephalopathy syndrome (PRES) is a rare complication of porphyria. Read More

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http://dx.doi.org/10.7759/cureus.3351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255715PMC
September 2018
1 Read

Autonomic dysfunction and HPV immunization: an overview.

Immunol Res 2018 Nov 27. Epub 2018 Nov 27.

Rheumatology Department, National Institute of Cardiology, Mexico City, Mexico.

This article reviews the case series reported from several countries describing patients with suspected severe side effects to the HPV vaccines. The described symptom clusters are remarkably similar and include disabling fatigue, headache, widespread pain, fainting, gastrointestinal dysmotility, limb weakness, memory impairment episodes of altered awareness, and abnormal movements. This constellation of symptoms and signs has been labeled with different diagnoses such as complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), small fiber neuropathy (SFN), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), or fibromyalgia. Read More

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http://dx.doi.org/10.1007/s12026-018-9036-1DOI Listing
November 2018
1 Read

Non-Syndromic Craniosynostosis Mimicking Primary Pseudotumor Cerebri Syndrome.

Headache 2018 Nov 25. Epub 2018 Nov 25.

Department of Pediatric Neurology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1111/head.13450DOI Listing
November 2018
1 Read

Cognitive Behavioral Therapy for Pediatric Headache and Migraine: Why to Prescribe and What New Research Is Critical for Advancing Integrated Biobehavioral Care.

Headache 2018 Nov 16. Epub 2018 Nov 16.

Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Purpose Of Review: To highlight current evidence supporting the prescription of cognitive behavioral therapy (CBT) as part of first-line preventive treatment for children and adolescents with headache and discuss a research strategy aimed at: (1) understanding how and why CBT works, and (2) developing effective and efficient approaches for integrating CBT into headache specialty, neurology, and primary care settings.

Recent Findings: Although preventive medications for pediatric headache and migraine are commonly prescribed, recent meta-analyses and an NIH-funded, multi-center clinical trial suggests that the effect of pill-taking therapies may be mostly due to a placebo effect. These findings have led to greater consideration of prescription of non-pharmacological therapies as first-line interventions (either alone or in combination with pill-based therapy). Read More

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http://dx.doi.org/10.1111/head.13438DOI Listing
November 2018
5 Reads

Headache attributed to aeroplane travel: the first multicentric survey in a paediatric population affected by primary headaches.

J Headache Pain 2018 Nov 14;19(1):108. Epub 2018 Nov 14.

Juvenile Headache Centre, University of Padua, via Giustiniani 3, 35128, Padua, Italy.

Background: This multicentric survey investigates the prevalence and characteristics of Airplane Headache in children affected by primary headaches.

Methods: Patients with symptoms of Airplane Headache were recruited from nine Italian Pediatric Headache Centres. Each patient was handed a structured questionnaire which met the ICHD-III criteria. Read More

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https://thejournalofheadacheandpain.biomedcentral.com/articl
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http://dx.doi.org/10.1186/s10194-018-0939-yDOI Listing
November 2018
2 Reads
2.801 Impact Factor

Efficacy of CoQ10 as supplementation for migraine: A meta-analysis.

Acta Neurol Scand 2018 Nov 14. Epub 2018 Nov 14.

Department of Neurology, Shaanxi Provincial People's Hospital, Third Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.

Objectives: Migraine ranks among the most frequent neurological disorders globally. Co-enzyme Q10 (CoQ10) is a nutritional agent that might play a preventative role in migraine. This meta-analysis aimed to investigate the effects of CoQ10 as a supplemental agent in migraine. Read More

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http://doi.wiley.com/10.1111/ane.13051
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http://dx.doi.org/10.1111/ane.13051DOI Listing
November 2018
7 Reads

Ombitasvir/Paritaprevir/Ritonavir With or Without Dasabuvir and With or Without Ribavirin for Adolescents With HCV Genotype 1 or 4.

Hepatol Commun 2018 Nov 5;2(11):1311-1319. Epub 2018 Oct 5.

Department of Pediatrics University of California San Francisco San Francisco CA.

In adults, treatment of hepatitis C virus (HCV) infection with ombitasvir (OBV)/paritaprevir (PTV)/ritonavir (r) with or without dasabuvir (DSV) and ±ribavirin (RBV) results in high rates of sustained virologic response (SVR). However, these regimens have not been investigated in adolescents. This ongoing, open-label, phase 2/3 study evaluated the pharmacokinetics, safety, and efficacy of OBV/PTV/r+DSV±RBV treatment for 12 weeks in adolescents infected with HCV genotype (GT) 1 without cirrhosis (part 1) and the safety and efficacy of OBV/PTV/r±DSV±RBV treatment for 12 or 24 weeks in adolescents infected with GT1 or GT4 without cirrhosis or with compensated cirrhosis (parts 1 and 2). Read More

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http://dx.doi.org/10.1002/hep4.1250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211326PMC
November 2018
5 Reads

Prophylaxis with melatonin for primary stabbing headache in pediatrics: a case report.

Colomb Med (Cali) 2018 Sep 30;49(3):244-248. Epub 2018 Sep 30.

Escuela de Medicina, Facultad de Salud,Universidad del Valle, Cali, Colombia.

Introduction: Primary stabbing headache (or "ice pick headache") is an alteration characterized by brief jabs (short stabs of pain, lasting ~3 seconds), which appear spontaneously, irregularly, and affecting unilaterally or bilaterally. Indomethacin has traditionally been used as the main therapeutic option. However, this drug is ineffective in a considerable percentage of patients and can generate multiple adverse effects that occur at therapeutic doses. Read More

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http://dx.doi.org/10.25100/cm.v49i2.3857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220483PMC
September 2018
6 Reads

Intracranial Ewing sarcoma with whole genome study.

Childs Nerv Syst 2018 Nov 7. Epub 2018 Nov 7.

Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Introduction: Ewing sarcoma (ES) as a primary intracranial tumor is very rare. Recently, CNS embryonal tumors with ES-like genomic change have been reported. Patients and methods We report a case of intracranial Ewing sarcoma in a 13-year-old girl who complained of headache and migraine. Read More

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http://dx.doi.org/10.1007/s00381-018-3997-1DOI Listing
November 2018
1 Read

Telemedicine and Child Neurology.

J Child Neurol 2018 Nov 5:883073818807516. Epub 2018 Nov 5.

3 Departments of Neurology and Pediatrics, University of Washington, Seattle, WA, USA.

Over the past 2 decades, various telehealth technologies, in particular synchronous video teleconferencing between provider and patient, have been incorporated into the practice of neurology. The practice of child neurology is now starting to take advantage of these rapidly evolving resources. This review describes the evolution of tele-neurology, starting with adult tele-stroke services and expanding to the management of both adults and children with a variety of chronic neurologic disorders including epilepsy, headache, movement disorders, and neurodevelopmental disabilities. Read More

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http://dx.doi.org/10.1177/0883073818807516DOI Listing
November 2018
5 Reads

Dual Delayed-Release Dexlansoprazole for Healing and Maintenance of Healed Erosive Esophagitis: A Safety Study in Adolescents.

Dig Dis Sci 2018 Nov 2. Epub 2018 Nov 2.

Takeda Development Center Americas, Inc, Deerfield, IL, USA.

Background: In gastroesophageal reflux disease (GERD), the frequency of heartburn symptoms and erosive esophagitis (EE) increases with age in children and adolescents. Proton pump inhibitor, dexlansoprazole, is approved for healing EE of all grades, maintenance of healed EE, relief of heartburn, and treatment of symptomatic non-erosive GERD in patients ≥ 12 years.

Aim: To assess safety and efficacy of dexlansoprazole dual delayed-release capsule in healing of EE and maintenance of healed EE in adolescents. Read More

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http://dx.doi.org/10.1007/s10620-018-5325-8DOI Listing
November 2018
2 Reads

Neurotoxicity Associated with CD19-Targeted CAR-T Cell Therapies.

CNS Drugs 2018 Dec;32(12):1091-1101

Clinical Research Division and Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Neurotoxicity is an important and common complication of chimeric antigen receptor-T cell therapies. Acute neurologic signs and/or symptoms occur in a significant proportion of patients treated with CD19-directed chimeric antigen receptor-T cells for B-cell malignancies. Clinical manifestations include headache, confusion, delirium, language disturbance, seizures and rarely, acute cerebral edema. Read More

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http://dx.doi.org/10.1007/s40263-018-0582-9DOI Listing
December 2018
2 Reads

Potentially addictive properties of sugar-sweetened beverages among adolescents.

Appetite 2018 Oct 29;133:130-137. Epub 2018 Oct 29.

University of California, Berkeley, Community Health Sciences, School of Public Health, 2121 Berkeley Way, Room 5302, Berkeley, CA, 94720, USA. Electronic address:

Sugar-sweetened beverages (SSBs) increase risk of cardiometabolic disease. Young people consume the largest amounts of SSBs and have experienced the greatest relative gains in obesity in the past several decades. There is evidence of addictive properties of both caffeine and sugar, the primary ingredients in SSBs, but little research into such properties of SSBs in naturally occurring consumption patterns. Read More

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http://dx.doi.org/10.1016/j.appet.2018.10.032DOI Listing
October 2018
1 Read

Physical-Mental Comorbidity of Pediatric Migraine in the Philadelphia Neurodevelopmental Cohort.

J Pediatr 2018 Oct 29. Epub 2018 Oct 29.

Genetic Epidemiology Branch, National Institute of Mental Health, Bethesda, MD. Electronic address:

Objective: To examine the associations between headaches and migraine with physical and mental disorders in a large pediatric registry.

Study Design: In total, 9329 youth aged 8-21 years from the Philadelphia Neurodevelopmental Cohort were included. Physical conditions, including headache, were ascertained from electronic medical records and in-person interviews. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223476183130
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http://dx.doi.org/10.1016/j.jpeds.2018.09.033DOI Listing
October 2018
2 Reads

Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study: A Randomized Clinical Trial.

JAMA Neurol 2018 Oct 29. Epub 2018 Oct 29.

Department of Neurology and Neurological Sciences, Stanford University, Stanford, California.

Importance: Young mouse plasma restores memory in aged mice, but, to our knowledge, the effects are unknown in patients with Alzheimer disease (AD).

Objective: To assess the safety, tolerability, and feasibility of infusions of young fresh frozen plasma (yFFP) from donors age 18 to 30 years in patients with AD.

Design, Setting, And Participants: The Plasma for Alzheimer Symptom Amelioration (PLASMA) study randomized 9 patients under a double-blind crossover protocol to receive 4 once-weekly infusions of either 1 unit (approximately 250 mL) of yFFP from male donors or 250 mL of saline, followed by a 6-week washout and crossover to 4 once-weekly infusions of an alternate treatment. Read More

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaneurol.2018.3288DOI Listing
October 2018
3 Reads

Prevalence, determinants and knowledge of antibacterial self-medication: A cross sectional study in North-eastern Tanzania.

PLoS One 2018 31;13(10):e0206623. Epub 2018 Oct 31.

Department of Microbiology, Immunology and Molecular Biology, Kilimanjaro Christian Medical University College, Moshi, Kilimanjaro, Tanzania.

Self-medication is very common especially in developing countries and is documented to be associated with many health risks including antibiotic resistance. This study investigated the prevalence, determinants and knowledge of self-medication among residents of Siha District in Tanzania. A cross-sectional study was conducted among 300 residents in a rural District of Kilimanjaro region, North-eastern Tanzania from 1st to 28th April 2017. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206623PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209340PMC
October 2018
10 Reads
3.230 Impact Factor

Recurrent Painful Cranial Neuropathy in a Child Involving Multiple Cranial Nerves.

Headache 2018 Oct 31. Epub 2018 Oct 31.

Department of Pediatrics and Neurology, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit, MI, USA.

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http://doi.wiley.com/10.1111/head.13430
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http://dx.doi.org/10.1111/head.13430DOI Listing
October 2018
5 Reads

Pediatric Bilateral Facial Paralysis: An Unusual Presentation of Lyme Disease.

Pediatr Emerg Care 2018 Oct 25. Epub 2018 Oct 25.

Department of Pediatrics and Emergency Medicine, Section of Pediatric Emergency Medicine, Yale University School of Medicine, New Haven, CT.

Pediatric bilateral facial nerve paralysis (FNP) is a rare condition, representing less than 2% of all cases of FNP. The differential diagnosis of FNP is extensive (ranging from infectious, traumatic, neurologic, to idiopathic) and often can present as a diagnostic challenge. In contrast to unilateral presentation, bilateral FNP presents as a manifestation of serious systemic conditions, including meningitis (infectious and neoplastic), brain stem encephalitis, Guillain-Barre syndrome, sarcoidosis, Lyme disease, human immunodeficiency virus infection, leukemia, and vasculitis. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001648DOI Listing
October 2018
15 Reads

A Modern Epidemic: Increasing Pediatric Emergency Department Visits and Admissions for Headache.

Pediatr Neurol 2018 Dec 4;89:19-25. Epub 2018 Aug 4.

A Children's Hospital of Pittsburgh of UPMC, Department of Pediatrics, Pittsburgh, Pennsylvania.

Objective: Headaches represent 0.9% to 2.6% of visits to a pediatric emergency department (PED). Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.07.015DOI Listing
December 2018
1 Read

Urinary Leukotriene E as a Biomarker of Exposure, Susceptibility, and Risk in Asthma: An Update.

Immunol Allergy Clin North Am 2018 11 21;38(4):599-610. Epub 2018 Sep 21.

Department of Pediatrics, Division of Allergy and Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA. Electronic address:

Measurement of urinary leukotriene E (uLTE) is a sensitive and noninvasive method of assaying total body cysteinyl leukotriene (CysLT) production and changes in CysLT production. Recent studies have reported on novel LTE4 receptor interactions and genetic polymorphisms causing CysLT variability. The applications of uLTE as a biomarker continue to expand, including evaluation of environmental exposures, asthma severity risk, aspirin sensitivity, predicting atopy in preschool age children, obstructive sleep apnea, and predicting susceptibility to leukotriene receptor antagonists. Read More

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http://dx.doi.org/10.1016/j.iac.2018.06.011DOI Listing
November 2018
1 Read

Acute pancreatitis associated with indigo naturalis in pediatric severe Crohn's disease.

Intest Res 2018 Oct 16. Epub 2018 Oct 16.

Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea.

The incidence of inflammatory bowel disease (IBD) is rapidly increasing worldwide. Indigo naturalis is known to have an antiinflammatory effect. Indigo naturalis has been traditionally used in the treatment of IBD in China and Japan. Read More

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http://dx.doi.org/10.5217/ir.2018.00104DOI Listing
October 2018
5 Reads

Facial nerve palsy associated with atomoxetine-induced hypertension.

Brain Dev 2018 Oct 9. Epub 2018 Oct 9.

Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan.

Background: Peripheral facial nerve palsy is characterized by unilateral facial paresis due to ipsilateral facial nerve dysfunction. Most cases are idiopathic; however, some have specific etiologies, such as herpesvirus infection, immunological disorders, and hypertension. Atomoxetine is a norepinephrine reuptake inhibitor that is used in the treatment of attention deficit hyperactivity disorder (ADHD). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604183016
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http://dx.doi.org/10.1016/j.braindev.2018.09.009DOI Listing
October 2018
13 Reads

Clinical manifestations of headache in children younger than 7 years.

Korean J Pediatr 2018 Nov 16;61(11):355-361. Epub 2018 Sep 16.

Department of Pediatrics, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.

Purpose: Headache is a common symptom during childhood. It is usually persistent and requires special care. This study aimed to identify the characteristics of headache in children <7 years of age. Read More

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http://kjp.or.kr/journal/view.php?doi=10.3345/kjp.2018.06331
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http://dx.doi.org/10.3345/kjp.2018.06331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258963PMC
November 2018
8 Reads

Diagnostic yield of head CT in pediatric emergency department patients with acute psychosis or hallucinations.

Pediatr Radiol 2018 Oct 5. Epub 2018 Oct 5.

Department of Radiology, Division of Emergency Radiology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 E. 210th St., Bronx, NY, 10467, USA.

Background: Children presenting to the emergency department with acute psychosis or hallucinations sometimes undergo a head CT to evaluate for a causative lesion. The diagnostic yield of head CT in this scenario has not been reported.

Objective: To determine the yield for head CT in children with acute psychosis or hallucinations. Read More

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http://dx.doi.org/10.1007/s00247-018-4265-yDOI Listing
October 2018

Reversible posterior encephalopathy syndrome in a 10-year-old child.

J Bras Nefrol 2018 Sep 21. Epub 2018 Sep 21.

Universidade Federal de Viçosa, Departamento de Medicina e Enfermagem (DEM), Viçosa, MG, Brasil.

Introduction: The posterior reversible encephalopathy (PRES) syndrome encompasses a set of clinical-radiological findings associated with severe systemic arterial hypertension. This case report proposes to discuss the identification, diagnosis, and management of PRES in the pediatric population.

Case Presentation: Female patient, 10 years old, admitted to the emergency room with complaint of oliguria and generalized edema. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/2175-8239-JBN-2018-0111DOI Listing
September 2018
3 Reads

Case 2: Headaches with Recurrent Rash and Mucosal Ulcerations.

Pediatr Rev 2018 Oct;39(10):519-522

Department of Pediatrics, CMC Myers Park Pediatrics/CHS-Levine Children's, Charlotte, NC.

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http://dx.doi.org/10.1542/pir.2017-0231DOI Listing
October 2018
1 Read

Opioid Prescribing Practices for Pediatric Headache.

J Pediatr 2018 Sep 28. Epub 2018 Sep 28.

Center for Policy Research-Emergency Medicine, Department of Emergency Medicine, Oregon Health & Science University, Portland, OR.

Objectives: To characterize the frequency of opioid prescribing for pediatric headache in both ambulatory and emergency department (ED) settings, including prescribing rates by provider type.

Study Design: A retrospective cohort study of Washington State Medicaid beneficiaries, aged 7-17 years, with an ambulatory care or ED visit for headache between January 1, 2012, and September 30, 2015. The primary outcome was any opioid prescribed within 1 day of the visit. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.08.078DOI Listing
September 2018
4 Reads

Therapeutic regimen of L-arginine for MELAS: 9-year, prospective, multicenter, clinical research.

J Neurol 2018 Dec 29;265(12):2861-2874. Epub 2018 Sep 29.

Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan.

Objective: To examine the efficacy and safety of the therapeutic regimen using oral and intravenous L-arginine for pediatric and adult patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS).

Methods: In the presence and absence of an ictus of stroke-like episodes within 6 h prior to efficacy assessment, we correspondingly conducted the systematic administration of oral and intravenous L-arginine to 15 and 10 patients with MELAS in two, 2-year, prospective, multicenter clinical trials at 10 medical institutions in Japan. Subsequently, patients were followed up for 7 years. Read More

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http://dx.doi.org/10.1007/s00415-018-9057-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244654PMC
December 2018
18 Reads

Identifying Persistent Postconcussion Symptom Risk in a Pediatric Sports Medicine Clinic.

Am J Sports Med 2018 Nov 28;46(13):3254-3261. Epub 2018 Sep 28.

The Micheli Center for Sports Injury Prevention, Waltham, Massachusetts, USA.

Background:: Although most children report symptom resolution within a month of a concussion, some patients experience persistent postconcussion symptoms (PPCS) that continues for more than 1 month. Identifying patients at risk for PPCS soon after an injury can provide useful clinical information.

Purpose:: To determine if the Predicting Persistent Post-concussive Problems in Pediatrics (5P) clinical risk score, an emergency department (ED)-derived and validated tool, is associated with developing PPCS when obtained in a primary care sports concussion setting. Read More

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http://dx.doi.org/10.1177/0363546518796830DOI Listing
November 2018
5 Reads

The impact of reactogenicity after the first dose of recombinant zoster vaccine upon the physical functioning and quality of life of older adults: an open phase III trial.

J Gerontol A Biol Sci Med Sci 2018 Sep 25. Epub 2018 Sep 25.

GSK, Wavre, Belgium.

Background: Herpes zoster (HZ) and its related complications are associated with significant medical burden, which negatively impacts patients' quality-of-life (QoL) and daily functioning. The recently licensed recombinant zoster vaccine (RZV) offers high efficacy, but is associated with local and systemic reactions. This study assessed the impact of RZV upon the QoL and daily functioning of participants and implications for caregivers. Read More

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https://academic.oup.com/biomedgerontology/advance-article/d
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http://dx.doi.org/10.1093/gerona/gly218DOI Listing
September 2018
2 Reads

Zika Virus: A Review of Literature.

Cureus 2018 Jul 22;10(7):e3025. Epub 2018 Jul 22.

Pediatrics, Shanghai Jiao Tong University School of Medicine/Shanghai Xin Hua Hospital, Shanghai, CHN.

Zika virus (ZIKV) is an arthropod-borne virus that was first isolated in 1947. Since then, multiple outbreaks of ZIKV have been reported in different countries. It is transmitted mostly by Aedes mosquitoes, and the symptoms of fever, joint pain, red eyes, headache, and maculopapular rash closely resemble chikungunya and dengue. Read More

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http://dx.doi.org/10.7759/cureus.3025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150742PMC

The Effectiveness of Ledipasvir/Sofosbuvir in Youth With Genotype 4 Hepatitis C Virus: A Single Egyptian Center Study.

Pediatr Infect Dis J 2019 Jan;38(1):22-25

Pediatrics, National Hepatology and Tropical Medicine Research Institute (NHTMRI), Cairo, Egypt.

Background: Licensure of ledipasvir/sofosbuvir for chronic hepatitis C virus (HCV) infection in adolescents was based on clinical trials on patients mainly with genotype 1. We aimed to evaluate the effectiveness and short-term safety of this newly approved antiviral in adolescents with HCV genotype 4.

Methods: This was a study of 51 HCV-infected adolescents, who received the adult dose of ledipasvir/sofosbuvir, once daily for 12 weeks, and were followed-up for 12 weeks post-treatment. Read More

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http://dx.doi.org/10.1097/INF.0000000000002189DOI Listing
January 2019

Migraine in children: presentation, disability and response to treatment.

Curr Opin Pediatr 2018 Dec;30(6):775-779

Division of Neurology, Cincinnati Children's Hospital Medical Center.

Purpose Of Review: The current review presents findings from investigations of migraine in children. The presentation of pediatric migraine, related consequences, and medication treatments are reviewed.

Recent Findings: A number of advancements have been made in the study of the presentation, disability, and treatments for migraine in children. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000694DOI Listing
December 2018

Sustained Viral Response in Genotype 4 Chronic Hepatitis C Virus-infected Children and Adolescents Treated With Sofosbuvir/Ledipasvir.

J Pediatr Gastroenterol Nutr 2018 Nov;67(5):626-630

Department of Pediatrics, Kasr Alainy Medical School, Cairo University, Cairo, Egypt.

Objectives: Recently, direct acting antivirals (DAAs), sofosbuvir (SOF) combined with ledipasvir (LED), were approved for treatment of hepatitis C virus (HCV)-infected children 12 years of age and older or weighting at least 35 kg for all HCV genotypes. The aim of this study was to assess the safety and efficacy of SOF/LED in genotype 4 HCV-infected Egyptian children and adolescents.

Methods: This observational study included 40 consecutive HCV-infected children of age 12 to <18 years old or weighing >35 kg, both treatment-naive and treatment-experienced. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002101DOI Listing
November 2018
1 Read

Neurological symptoms in Hypophosphatasia.

Osteoporos Int 2018 Sep 13. Epub 2018 Sep 13.

Department of Pediatrics, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.

Hypophosphatasia (HPP) typically manifests with fractures, tooth loss, and muscle pain. Although mental health diagnoses and neurological symptoms have not been previously well documented in HPP, they occur commonly. The recognition of non-traditional symptoms may improve patient satisfaction, preempt costly evaluation and misdiagnosis, and lead to further treatment options. Read More

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http://link.springer.com/10.1007/s00198-018-4691-6
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http://dx.doi.org/10.1007/s00198-018-4691-6DOI Listing
September 2018
5 Reads

Epidural cerebrospinal fluid collection following lumbar puncture in an adult patient: A case report and literature review.

Surg Neurol Int 2018 22;9:169. Epub 2018 Aug 22.

University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Background: Cerebrospinal fluid (CSF) leakage into the epidural space following lumbar puncture (LP) has been documented in pediatric patients, but there have been no reported cases in adults.

Case Description: We report an epidural CSF leak in an adult who presented with back pain, positional headache, urinary retention, and constipation following an LP performed as a part of a research study. The patient's magnetic resonance (MR) scan showed an extensive epidural CSF collection. Read More

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http://dx.doi.org/10.4103/sni.sni_476_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122281PMC
August 2018
1 Read

Headache due to Spontaneous Spinal Cerebrospinal Fluid Leaks.

Intern Med 2018 Sep 12. Epub 2018 Sep 12.

Department of Pediatrics, National Hospital Organization Fukuyama Medical Center, Japan.

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http://dx.doi.org/10.2169/internalmedicine.1136-18DOI Listing
September 2018

Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis.

N Engl J Med 2018 09;379(11):1017-1027

From the Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital, Boston (T.C.); Montreal Neurological Institute, McGill University, and NeuroRx Research - both in Montreal (D.L.A.); Children's Hospital of Philadelphia (B.B.) and the Center for Neuroinflammation and Experimental Neurotherapeutics and the Department of Neurology (A.B.-O.), Perelman School of Medicine, University of Pennsylvania - all in Philadelphia; the Department of Neuropathology (W.B.) and the Department of Pediatrics and Adolescent Medicine, German Center for Multiple Sclerosis in Childhood and Adolescence (J.G.), University Medical Center Göttingen, Göttingen, and the Division of Pediatric Neurology, Children's Hospital Datteln, Witten/Herdecke University, Datteln (K.R.) - all in Germany; Gallarate Hospital, Gallarate, Italy (A.G.); Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London (G.G.); the University of Texas Southwestern Medical Center, Children's Health, Dallas (B.G.), and McGovern Medical School, University of Texas Health Science Center at Houston, Houston (J.S.W.) - both in Texas; Pediatric Multiple Sclerosis Center at NYU Langone, New York (L.K.); Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Paris (M.T.); the Department of Neurology, University of California at San Francisco, San Francisco (E.W.); Novartis Pharmaceuticals, East Hanover, NJ (T.S., Y.C., N.P.); and Novartis Pharma, Basel, Switzerland (M.M.).

Background: Treatment of patients younger than 18 years of age with multiple sclerosis has not been adequately examined in randomized trials. We compared fingolimod with interferon beta-1a in this population.

Methods: In this phase 3 trial, we randomly assigned patients 10 to 17 years of age with relapsing multiple sclerosis in a 1:1 ratio to receive oral fingolimod at a dose of 0. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1800149
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http://dx.doi.org/10.1056/NEJMoa1800149DOI Listing
September 2018
20 Reads

Benign nocturnal alternating hemiplegia of childhood: A clinical and nomenclatural reappraisal.

Eur J Paediatr Neurol 2018 Aug 15. Epub 2018 Aug 15.

Department of Pediatric Neurology & Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.

Objective: To describe the clinical spectrum of benign nocturnal alternating hemiplegia of childhood (BNAHC) including long-term follow-up data of previously published cases and to propose an underlying genetic cause of this disorder.

Methods: We studied the medical data of two novel patients, reviewed the literature on BNAHC, and gathered information of the most recent follow-up of published cases regarding the course of episodes, further development, attempted drugs, ancillary investigations, and sequelae.

Results: All patients, i. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.07.012DOI Listing
August 2018
2 Reads

Correction: Esparham, A., et al., Pediatric Integrative Medicine: Vision for the Future. Children, 2018, 5, 111.

Children (Basel) 2018 Sep 5;5(9). Epub 2018 Sep 5.

Whole Child Center, Oradell, NJ 07649, USA.

The authors wish to make the following corrections to their paper [... Read More

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http://dx.doi.org/10.3390/children5090123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162747PMC
September 2018

Posttraumatic headache in pediatrics: an update and review.

Authors:
Heidi K Blume

Curr Opin Pediatr 2018 Dec;30(6):755-763

Division of Pediatric Neurology, University of Washington, Seattle Children's Hospital and Research Institute, Seattle, Washington, USA.

Purpose Of Review: Headache following concussion and mild traumatic brain injury is very common in pediatrics. There is significant concern about appropriate management of acute and persistent headache following mild head injuries in children among affected youth, their families and care providers.

Recent Findings: The current article will review definitions and diagnoses of posttraumatic headache (PTHA), recent research regarding risk factors for persistence of postconcussion symptoms and headaches, current recommendations for the evaluation of youth with PTHA, recent data regarding efficacy of treatment options for PTHA, and current recommendations for the treatment of acute and persistent PTHA. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000691DOI Listing
December 2018

Intracranial hypertension: a current review.

Curr Opin Pediatr 2018 Dec;30(6):764-774

Department of Neurology, Nationwide Children's Hospital, Columbus, Ohio, USA.

Purpose Of Review: To provide a current review of recent publications with regards to intracranial hypertension.

Recent Findings: Attempts were made to provide pediatric data; however, the recent completion of the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) has provided a wealth of data with regards to adult intracranial hypertension.The pediatric incidence of intracranial hypertension ranges between 0. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000689DOI Listing
December 2018
9 Reads

Measuring Dynamic Symptom Response in Concussion: Children's Exertional Effects Rating Scale.

J Head Trauma Rehabil 2018 Aug 30. Epub 2018 Aug 30.

Division of Pediatric Neuropsychology, Children's National Health System, and Departments of Pediatrics & Psychiatry and Behavioral Sciences, George Washington University School of Medicine, Washington, District of Columbia.

Objective: To introduce and evaluate a measure of momentary symptom response to cognitive activity, a core feature of concussion.

Setting: Concussion clinic at a large regional children's hospital.

Participants: Individuals aged 5 to 18 years, comprising 3 clinical groups: uninjured (n = 590), recently concussed but clinically recovered (n = 160), and recently concussed but not yet recovered (n = 570). Read More

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http://dx.doi.org/10.1097/HTR.0000000000000424DOI Listing