236 results match your criteria Pediatrics Hand-Foot-and-Mouth Disease


Clinical characteristics and managements of severe hand, foot and mouth disease caused by enterovirus A71 and coxsackievirus A16 in Shanghai, China.

BMC Infect Dis 2019 Mar 27;19(1):285. Epub 2019 Mar 27.

Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.

Background: Hand, foot and mouth disease (HFMD) is a transmissible infectious disease caused by human enteroviruses (EV). Here, we described features of children with severe HFMD caused by EV-A71 or coxsackievirus A16 (CV-A16) in Shanghai, China.

Methods: Severe EV-A71 or CV-A16 caused HFMD children admitted to the Xinhua Hospital from January 2014 and December 2016, were recruited retrospectively to the study. Read More

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http://dx.doi.org/10.1186/s12879-019-3878-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438032PMC
March 2019
1 Read

Characterization of lymphocyte subsets in peripheral blood cells of children with EV71 infection.

J Microbiol Immunol Infect 2019 Mar 14. Epub 2019 Mar 14.

Virus Laboratory, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 318 Renminzhong Road Yuexiu District, Guangzhou, 510120, China. Electronic address:

Background: Enterovirus 71 (EV71) is one of the major causative pathogens of hand, foot, and mouth disease (HFMD). Immune cells play a critical role in determining the outcomes of virus infection. We aimed to characterize the lymphocyte subsets and transcriptional levels of T lymphocytes-associated transcription factors in peripheral blood cells of children with EV71 infection. Read More

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http://dx.doi.org/10.1016/j.jmii.2019.03.001DOI Listing
March 2019
1 Read

Hand, foot and mouth disease caused by Coxsackie viruses A6 and A16 in Assam, Northeast India: A need for surveillance.

Indian J Dermatol Venereol Leprol 2019 Mar 12. Epub 2019 Mar 12.

Regional Virus Research Diagnostic Laboratory, ICMR-Regional Medical Research Centre, N.E.Region, Dibrugarh, Assam, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_576_17DOI Listing
March 2019
2 Reads

Type III interferon signaling restricts enterovirus 71 infection of goblet cells.

Sci Adv 2019 Mar 6;5(3):eaau4255. Epub 2019 Mar 6.

Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Recent worldwide outbreaks of enterovirus 71 (EV71) have caused major epidemics of hand, foot, and mouth disease with severe neurological complications, including acute flaccid paralysis. EV71 is transmitted by the enteral route, but little is known about the mechanisms it uses to cross the human gastrointestinal tract. Using primary human intestinal epithelial monolayers, we show that EV71 infects the epithelium from the apical surface, where it preferentially infects goblet cells. Read More

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http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aau
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http://dx.doi.org/10.1126/sciadv.aau4255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402847PMC
March 2019
14 Reads

Epidemiologic features of enterovirus associated with hand, foot and mouth disease in 2013 and 2014 in Shenzhen, China.

Sci Rep 2019 Mar 7;9(1):3856. Epub 2019 Mar 7.

Department of Epidemiology, The Key Laboratory of Public Health Safety of Minister of Education, School of Public Health, Fudan University, Shanghai, 200032, China.

Hand, foot and mouth disease (HFMD) is responsible for a heavy economic and social burden in the Asia-Pacific region. Previous studies have shown that coxsackievirus A6 (CVA6) and coxsackievirus A10 (CVA10) have become the predominant agents of HFMD in mainland China in recent years, replacing enterovirus 71 (EV71) and coxsackievirus A16 (CVA16), although it is unclear if this is consistent throughout China. In this study, samples from 253 HFMD cases were collected in Shenzhen, China, from May 2013 through April 2014 to identify the etiological agent of HFMD. Read More

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http://dx.doi.org/10.1038/s41598-019-40402-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405776PMC
March 2019
3 Reads

Recombinant virus-like particle presenting a newly identified coxsackievirus A10 neutralization epitope induces protective immunity in mice.

Antiviral Res 2019 Apr 25;164:139-146. Epub 2019 Feb 25.

Vaccine Research Center, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China; Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. Electronic address:

Coxsackievirus A10 (CVA10) has emerged as one of the major pathogens of hand, foot, and mouth disease in recent years. However, there are no approved vaccines or effective drugs against CVA10. Several experimental CVA10 vaccines have been shown to elicit neutralizing antibodies that could confer protection against viral infection. Read More

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http://dx.doi.org/10.1016/j.antiviral.2019.02.016DOI Listing
April 2019
3 Reads
3.938 Impact Factor

Identifying risk factors for neurological complications and monitoring long-term neurological sequelae: protocol for the Guangzhou prospective cohort study on hand-foot-and-mouth disease.

BMJ Open 2019 Feb 24;9(2):e027224. Epub 2019 Feb 24.

Department of Infectious Diseases, Guangzhou Women and Children's Medical Center, Guangzhou, China.

Introduction: Hand-foot-and-mouth disease (HFMD) is a paediatric infectious disease that is particularly prevalent in China. Severe HFMDs characterised by neurological involvement are fatal and survivors who have apparently fully recovered might still be afflicted later in life with neurocognitive impairments. Only when a well-designed, prospective cohort study is in place can we develop clinical tools for early warning of neurological involvement and can we obtain epidemiological evidence regarding the lingering effects of the sequelea. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443074PMC
February 2019
2 Reads
2.063 Impact Factor

A case report of a teenager with severe hand, foot, and mouth disease with brainstem encephalitis caused by enterovirus 71.

BMC Pediatr 2019 Feb 13;19(1):59. Epub 2019 Feb 13.

Intensive Care Unit, Key Medical Laboratory of Pediatrics, Chongqing Health Bureau, Ministry of Education; Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Background: Hand, foot, and mouth disease (HFMD) is an acute viral infection occurring mostly in infants and children. Enterovirus 71 (EV71) infection mostly occurs in children < 5 years of age. Severe cases, however, are usually encountered in children under the age of 3 years, and exceedingly rare in teenagers > 14 years and adults. Read More

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http://dx.doi.org/10.1186/s12887-019-1428-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373151PMC
February 2019
6 Reads
1.918 Impact Factor

MRI reveals segmental distribution of enterovirus lesions in the central nervous system: a probable clinical evidence of retrograde axonal transport of EV-A71.

J Neurovirol 2019 Feb 7. Epub 2019 Feb 7.

Guangzou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China.

Enterovirus 71 (EV-A71) is a major causative agent for hand, foot, and mouth disease (HFMD), especially severe HFMD characterized by neurologic involvement. The objective of this study is to investigate the relationship between the distribution of neurologic infection and the outcomes of severe HFMD. A total of 139 suspected severe HFMD cases (92 were confirmed as EV-A71 infection) underwent clinical and laboratory diagnosis as well as magnetic resonance imaging (MRI) scans of the nervous system. Read More

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http://dx.doi.org/10.1007/s13365-019-00724-3DOI Listing
February 2019
4 Reads

Profiles of Human Enteroviruses Associated with Hand, Foot, and Mouth Disease in Nanjing, China.

Disaster Med Public Health Prep 2019 Feb 1:1-5. Epub 2019 Feb 1.

Institute of Pediatrics,Children's Hospital of Nanjing Medical University,Nanjing,Jiangsu,China.

Objective: Hand, foot, and mouth disease (HFMD) is a common infectious disease caused by a group of viruses. The causative viruses have changed over time, and there is a need for a more effective protective vaccine. In this study, we investigated the profiles of human enteroviruses that caused HFMD outbreaks in Nanjing in 2015, with the goal of guiding the future prevention and treatment of HFMD. Read More

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https://www.cambridge.org/core/product/identifier/S193578931
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http://dx.doi.org/10.1017/dmp.2018.155DOI Listing
February 2019
9 Reads

Phylogenetic and antigenic analyses of coxsackievirus A6 isolates in Yamagata, Japan between 2001 and 2017.

Vaccine 2019 Feb 22;37(8):1109-1117. Epub 2019 Jan 22.

Department of Microbiology, Yamagata Prefectural Institute of Public Health, Yamagata 1-6-6, Yamagata 990-0031, Japan.

Although coxsackievirus A6 (CV-A6) is generally recognized as a causative agent of herpangina in children, CV-A6 infections globally emerged as a new and major cause of epidemic hand-foot-and-mouth-diseases (HFMDs) around 2008. To clarify the longitudinal epidemiology of CV-A6, we carried out sequence and phylogenetic analyses for the VP1 and partially for the VP4-3D regions as well as antigenic analysis using 115 CV-A6 isolates and 105 human sera in Yamagata, Japan between 2001 and 2017. Phylogenetic analysis revealed that CV-A6 isolates were clearly divided into two clusters; strains in circulation between 2001 and 2008 and those between 2010 and 2017. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.12.065DOI Listing
February 2019
4 Reads

Longitudinal study on enterovirus A71 and coxsackievirus A16 genotype/subgenotype replacements in hand, foot and mouth disease patients in Thailand, 2000-2017.

Int J Infect Dis 2019 Mar 11;80:84-91. Epub 2019 Jan 11.

Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok-noi, Bangkok 10700, Thailand; Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Nakhon Pathom 73170, Thailand. Electronic address:

Background: Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are the major causative agents of hand, foot and mouth disease (HFMD) worldwide, particularly in the Asia-Pacific region. Several strains have emerged, circulated, and faded out over time in recent decades. This study investigated the EV-A71 and CV-A16 circulating strains and replacement of genotypes/subgenotypes in Thailand during the years 2000-2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193001
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http://dx.doi.org/10.1016/j.ijid.2018.12.020DOI Listing
March 2019
5 Reads
2.330 Impact Factor

Casting New Light on Hand-Foot-and-Mouth Disease.

J Pediatr 2019 Apr 14;207:259-259.e1. Epub 2018 Dec 14.

Department of Dermatology and Pediatrics Columbia University New York, New York.

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http://dx.doi.org/10.1016/j.jpeds.2018.11.032DOI Listing

Complete genome analysis demonstrates multiple introductions of enterovirus 71 and coxsackievirus A16 recombinant strains into Thailand during the past decade.

Emerg Microbes Infect 2018 Dec 14;7(1):214. Epub 2018 Dec 14.

Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Nakhon, Pathom, 73170, Thailand.

Hand, foot, and mouth disease (HFMD) caused by enteroviruses remains a public health threat, particularly in the Asia-Pacific region during the past two decades. Moreover, the introduction of multiple subgenotypes and the emergence of recombinant viruses is of epidemiological importance. Based on either the full genome or VP1 sequences, 32 enteroviruses (30 from HFMD patients, 1 from an encephalitic patient, and 1 from an asymptomatic contact case) isolated in Thailand between 2006 and 2014 were identified as 25 enterovirus 71 (EV71) isolates (comprising 20 B5, 1 C2, 2 C4a, and 2 C4b subgenotypes) and 7 coxsackievirus A16 (CA16) isolates (comprising 6 B1a and 1 B1b subgenotypes). Read More

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http://www.nature.com/articles/s41426-018-0215-x
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http://dx.doi.org/10.1038/s41426-018-0215-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294798PMC
December 2018
2 Reads

Case of hand, foot and mouth disease with vesicular Koebner phenomenon on the ankles caused by Coxsackievirus A6 in an adult.

J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1111/1346-8138.14723DOI Listing
December 2018
2 Reads

Acute Kidney Injury Secondary to Severe Hand, Foot and Mouth Disease Caused by Enterovirus-A71: Hypertension Is a Common.

J Trop Pediatr 2018 Nov 19. Epub 2018 Nov 19.

Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Hand, foot and mouth disease (HFMD) is a common infectious disease among children, caused primarily by human enterovirus-A71 (EV-A71) and coxsackievirus-A16 (CV-A16). To date, only two case reports mention that renal involvement can be secondary to or coexisting with CV-A16-associated HFMD. In the present report, we describe a 10-year-old girl who was infected with EV-A71 and subsequently developed a definite acute kidney injury (AKI), mainly based on the characteristic rash, virus isolation, eyelid edema, hypertension, decreased urine output, mild proteinuria and impaired renal function. Read More

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http://dx.doi.org/10.1093/tropej/fmy070DOI Listing
November 2018
2 Reads
0.857 Impact Factor

The gut microbiota of hand, foot and mouth disease patients demonstrates down-regulated butyrate-producing bacteria and up-regulated inflammation-inducing bacteria.

Acta Paediatr 2018 Nov 14. Epub 2018 Nov 14.

Department of Paediatrics, West China Second Hospital, Sichuan University, Chengdu, China.

Aim: This study explored the gut microbiota of children with hand, foot and mouth disease (HFMD).

Methods: We enrolled 15 cases with HFMD admitted to the West China Second Hospital, Sichuan University, China, from July to September 2016 at a median age of three years. The controls were 15 healthy children of a similar age who underwent routine health examinations at the hospital during the same period. Read More

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http://doi.wiley.com/10.1111/apa.14644
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http://dx.doi.org/10.1111/apa.14644DOI Listing
November 2018
23 Reads

Nationwide Survey of Pediatric Inpatients With Hand, Foot, and Mouth Disease, Herpangina, and Associated Complications During an Epidemic Period in Japan: Estimated Number of Hospitalized Patients and Factors Associated With Severe Cases.

J Epidemiol 2018 Nov 10. Epub 2018 Nov 10.

Department of Public Health, Osaka City University Graduate School of Medicine.

Background: Severe pediatric cases of hand, foot, and mouth disease (HFMD), herpangina (HA), and associated complications caused by enterovirus 71 (EV71) infection have brought substantial public health impact in Asia. This study aimed to elucidate the epidemiology of these pediatric cases in Japan.

Methods: A nationwide survey was conducted using stratified random sampling of hospital pediatric departments. Read More

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http://dx.doi.org/10.2188/jea.JE20180060DOI Listing
November 2018
2 Reads

Seroprevalence of antibodies to enterovirus 71 and coxsackievirus A16 among people of various age groups in a northeast province of Thailand.

Virol J 2018 10 16;15(1):158. Epub 2018 Oct 16.

Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, 73170, Thailand.

Background: Hand, foot and mouth disease (HFMD) is endemic among population of young children in Thailand. The disease is mostly caused by enterovirus 71 (EV71) and coxsackievirus A16 (CA16).

Methods: This study conducted serosurveillance for neutralizing (NT) antibodies to EV71 subgenotypes B5 and C4a, and to CA16 subgenotypes B1a and B1b, in 579 subjects of various ages using a microneutralization assay in human rhabdomyosarcoma (RD) cells. Read More

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http://dx.doi.org/10.1186/s12985-018-1074-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192276PMC
October 2018
7 Reads
2.181 Impact Factor

Epidemiological Features of Hand, Foot and Mouth Disease Outbreaks among Chinese Preschool Children: A Meta-analysis.

Iran J Public Health 2018 Sep;47(9):1234-1243

Dept. of Public Health, Xuhui Central Hospital, Shanghai, China.

Background: Hand-foot-mouth disease (HFMD) is a widespread communicable disease and has caused large epidemics in many countries. This meta-analysis aimed to analyze and evaluate the epidemiological features of HFMD outbreaks in Chinese preschools.

Methods: Literature review was based on PubMed, Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases from 2008 to 2015. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174039PMC
September 2018

Chinese guidelines for the diagnosis and treatment of hand, foot and mouth disease (2018 edition).

World J Pediatr 2018 Oct 3;14(5):437-447. Epub 2018 Oct 3.

Department of Pediatrics, Yan'an Hospital of Kunming City, Kunming, China.

Background: Hand, foot, and mouth disease (HFMD) is a common infectious disease in childhood caused by an enterovirus (EV), and which is principally seen in children under 5 years of age. To promote diagnostic awareness and effective treatments, to further standardize and strengthen the clinical management and to reduce the mortality of HFMD, the guidelines for diagnosis and treatment have been developed.

Methods: National Health Commission of China assembled an expert committee for a revision of the guidelines. Read More

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http://dx.doi.org/10.1007/s12519-018-0189-8DOI Listing
October 2018
17 Reads

Small molecules targeting coxsackievirus A16 capsid inactivate viral particles and prevent viral binding.

Emerg Microbes Infect 2018 Sep 26;7(1):162. Epub 2018 Sep 26.

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.

Coxsackievirus A16 (CVA16) is an etiologic agent of hand, foot, and mouth disease (HFMD) that affects young children, and although typically self-limited, severe complications, and fatal cases have been reported. Due to the lack of specific medication and vaccines against CVA16, there is currently a need to develop effective antivirals to better control CVA16 infections in epidemic areas. In this study, we identified the tannins chebulagic acid (CHLA) and punicalagin (PUG) as small molecules that can efficiently disrupt the CVA16 infection of human rhabdomyosarcoma cells. Read More

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http://dx.doi.org/10.1038/s41426-018-0165-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156566PMC
September 2018
5 Reads

Temporal relationship between occurrences of hand, foot and mouth disease, respiratory virus detection and febrile seizures in children in tropical Singapore: a time-series analysis.

Epidemiol Infect 2018 Sep 13:1-6. Epub 2018 Sep 13.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System,Singapore,Singapore.

Febrile seizure (FS) in children is a common complication of infections with respiratory viruses and hand, foot and mouth disease (HFMD). We conducted a retrospective ecological time-series analysis to determine the temporal relationship between hospital attendances for FS and HFMD or respiratory virus infections. Epilepsy attendance was used as a control. Read More

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http://dx.doi.org/10.1017/S0950268818002509DOI Listing
September 2018
9 Reads

Understanding physician antibiotic prescribing behavior for children with enterovirus infection.

PLoS One 2018 7;13(9):e0202316. Epub 2018 Sep 7.

Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background: Our previous study demonstrated that pediatricians prescribe antibiotics without proper clinical justification to patients with enterovirus infection, although antibiotics are not effective in treating the infections caused by these viruses. To improve the quality of healthcare, we aim to evaluate the association of clinical and demographic characteristics of patients and further to identify the determining factors for prescribing antibiotics to children experiencing enterovirus infection.

Methods: We retrospectively reviewed the medical records of children who were hospitalized between January 2008 and December 2016 with a diagnosis of herpangina or hand-foot-mouth disease (HFMD). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202316PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128467PMC
February 2019
12 Reads

Sex differences in common childhood infections in Taiwan.

Int J Infect Dis 2018 Oct 28;75:115-117. Epub 2018 Aug 28.

Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.

Sex differences in childhood infections are commonly reported in case-only studies. In this population-based study of 278000 Taiwanese children followed from 3 months to 18 years of age during the period 2000-2012, age-trajectories of monthly numbers of all-cause healthcare visits and monthly rates of infection-specific healthcare visits were compared between boys and girls. For all-cause healthcare visits and for healthcare visits related to conjunctivitis, respiratory tract infections, enteritis, hand, foot, and mouth disease, and herpangina, there was good resemblance of age trajectories between boys and girls. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.08.014DOI Listing
October 2018
6 Reads

Polymorphism of OAS2 rs739901 C/A Involves the Susceptibility to EV71 Infection in Chinese Children.

Curr Med Sci 2018 Aug 20;38(4):640-647. Epub 2018 Aug 20.

Department of Pediatrics, the Affiliated Hospital of Qingdao University, Qirtgdao, 266000, China.

This study aimed to assess the relationship of OAS2 rs739901 5,-flanking C/A polymorphisms with the susceptibility to Enterovirus-71 (EV71) infection. We investigated 294 hand-foot-mouth disease (HFMD) Chinese children with EV71 infection (165 mild cases and 129 encephalitis cases). The improved multiplex ligation detection reaction (iMLDR) technique was used to test the genotypes. Read More

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http://link.springer.com/10.1007/s11596-018-1925-y
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http://dx.doi.org/10.1007/s11596-018-1925-yDOI Listing
August 2018
25 Reads

Factors associated with severe neurologic complications in patients with either hand-foot-mouth disease or herpangina: A nationwide observational study in South Korea, 2009-2014.

PLoS One 2018 10;13(8):e0201726. Epub 2018 Aug 10.

Department of Pediatrics, Hanyang University College of Medicine, Seoul, South Korea.

Background: In 2009, a nationwide sentinel surveillance for hand-foot-mouth disease (HFMD) and herpangina (HA) with neurologic complications was initiated in South Korea. We used this surveillance system to investigate the clinical characteristics of patients with either HFMD or HA with neurologic complications, with the aim of determining risk factors for severe neurologic complications.

Methods: A retrospective review of medical records was conducted on all cases of HFMD and HA with neurologic complications that were reported in the national system between April 1, 2009 and December 31, 2014. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201726PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086402PMC
February 2019
11 Reads

[Pathogen spectrum in enteroviral infections among children in Beijing from 2010 to 2016].

Zhonghua Er Ke Za Zhi 2018 Aug;56(8):575-581

Laboratory of Virology, Beijing Key Laboratory of Etiology of Viral Diseases in Children, Capital Institute of Pediatrics-Peking University Teaching Hospital, Beijing 100020, China.

To understand the epidemiological and etiological characteristics of enterovirus (EV)-associated diseases among children in Beijing from 2010 to 2016. This was a repeated cross-sectional study. The throat swabs were collected from children with probable EV-associated diseases at the Children' s Hospital Affiliated to Capital Institute of Pediatrics from 2010 to 2016. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.08.004DOI Listing
August 2018
36 Reads

A CpG-adjuvanted intranasal enterovirus 71 vaccine elicits mucosal and systemic immune responses and protects human SCARB2-transgenic mice against lethal challenge.

Sci Rep 2018 Jul 16;8(1):10713. Epub 2018 Jul 16.

Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.

Enterovirus 71 (EV71) is an aetiological agent responsible for seasonal epidemics of hand-foot-and-mouth disease, which causes considerable mortality among young children. Mucosal vaccines can efficiently induce secretory IgA at mucosal surfaces and thereby prevent or limit infection at the site of virus entry. CpG oligodeoxynucleotides (ODNs), which resemble bacterial DNA, can induce the innate immune response through activation of Toll-like receptor 9. Read More

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http://dx.doi.org/10.1038/s41598-018-28281-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048030PMC
July 2018
11 Reads

Genome-wide linear B-cell epitopes of enterovirus 71 in a hand, foot and mouth disease (HFMD) population.

J Clin Virol 2018 08 3;105:41-48. Epub 2018 Jun 3.

Department of pathogen diagnosis and biosafety, Shanghai public health clinical center, Fudan University, Shanghai, 201508, PR China. Electronic address:

Background: Enteroviruses cause hand, foot and mouth disease (HFMD). The host B-cells recognize the viral proteins and provoke humoral responses. Deciphering the B-cell responses to the viral epitopes helps diagnosis and vaccine development. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13866532183015
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http://dx.doi.org/10.1016/j.jcv.2018.06.001DOI Listing
August 2018
13 Reads

Coxsackievirus A6 (CV-A6) Encephalomyelitis in an Immunocompromised Child: a Case Report and Brief Review of the Literature.

Jpn J Infect Dis 2018 Sep 31;71(5):388-389. Epub 2018 May 31.

Manipal center for Virus Research, Manipal Academy of Higher Education.

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http://dx.doi.org/10.7883/yoken.JJID.2018.073DOI Listing
September 2018
1 Read
1.204 Impact Factor

Circulating Salivary miRNA hsa-miR-221 as Clinically Validated Diagnostic Marker for Hand, Foot, and Mouth Disease in Pediatric Patients.

EBioMedicine 2018 May 10;31:299-306. Epub 2018 May 10.

Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System, 5 Science Drive 2, National University of Singapore, 117597, Singapore; Collaborative and Translational Unit for HFMD, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore. Electronic address:

Enhancements in the diagnostic capabilities using host biomarkers are currently much needed where sensitivity and specificity issues plague the diagnosis of Hand, Foot and Mouth Disease (HFMD) in pediatrics clinical samples. We investigated miRNome profiles of HFMD saliva samples against healthy children and developed miRNA-based diagnosis models. Our 6-miRNA scoring model predicted HFMD with an overall accuracy of 85. Read More

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http://dx.doi.org/10.1016/j.ebiom.2018.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014581PMC
May 2018
30 Reads

Crosstalk between Toll-like receptor 3 and Notch signaling contributes to CD14 monocytes activity in enterovirus 71 infected hand, foot, and mouth disease.

Int Immunopharmacol 2018 Jul 24;60:26-33. Epub 2018 Apr 24.

Department of Pediatrics, First Affiliated Hospital of Xinxiang Medical University, Weihui, Xinxiang, Henan Province, PR China. Electronic address:

Interaction between Toll-like receptor (TLR) and Notch signaling contributes to inflammatory response in nephropathy and fungicidal infection, however, the role of this crosstalk remains not fully elucidated in enterovirus 71 (EV71)-induced hand, foot, and mouth disease (HFMD). The aim of this study was to investigate the crosstalk between TLR and Notch in inflammatory regulation in EV71 infection. Thirty-seven EV-71-indcued HFMD (16 mild and 21 severe cases) and eleven normal control (NC) were enrolled. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183018
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http://dx.doi.org/10.1016/j.intimp.2018.04.031DOI Listing
July 2018
9 Reads

Clinical profile and virology analysis of hand, foot and mouth disease cases from North Kerala, India in 2015-2016: A tertiary care hospital-based cross-sectional study.

Indian J Dermatol Venereol Leprol 2018 May-Jun;84(3):328-331

Department of Virus Research, Regional Reference Laboratory for Influenza Viruses and ICMR Virology Network Laboratory-Grade-I, Manipal Academy of Higher Education, Manipal, Karnataka, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_579_17DOI Listing
November 2018
2 Reads

Severity and burden of hand, foot and mouth disease in Asia: a modelling study.

BMJ Glob Health 2018 26;3(1):e000442. Epub 2018 Jan 26.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.

Background: Hand, foot and mouth disease (HFMD) affects millions of children across Asia annually, leading to an increase in implemented control policies such as surveillance, isolation and social distancing in affected jurisdictions. However, limited knowledge of disease burden and severity causes difficulty in policy optimisation as the associated economic cost cannot be easily estimated. We use a data synthesis approach to provide a comprehensive picture of HFMD disease burden, estimating infection risk, symptomatic rates, the risk of complications and death, and overall disability-adjusted life-year (DALY) losses, along with associated uncertainties. Read More

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http://dx.doi.org/10.1136/bmjgh-2017-000442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859810PMC
January 2018
2 Reads

Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia.

Sci Rep 2018 Mar 6;8(1):4087. Epub 2018 Mar 6.

Collaborative and Translation Unit for HFMD, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

Hand, foot and mouth disease (HFMD) is a prevalent contagious childhood disease typically associated with fever, oral lesions and limb exanthema. While HFMD is caused by a plethora of serotypes of viruses under the genus Enterovirus within the Picornaviridae family, Coxsackievirus A16 (CV-A16) and Enterovirus 71 (EV-A71) are considered the main etiological agents. In recent years however, other viruses have also been isolated in considerable numbers from infected individuals in many regions, joining the legion commonly associated with HFMD. Read More

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http://dx.doi.org/10.1038/s41598-018-22379-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840398PMC
March 2018
17 Reads
5.080 Impact Factor

Artemisia capillaris inhibited enterovirus 71-induced cell injury by preventing viral internalization.

Kaohsiung J Med Sci 2018 Mar 6;34(3):150-159. Epub 2017 Dec 6.

Department of Renal Care, College of Medicine, Kaohsiung Medical University, Taiwan; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan. Electronic address:

Artemisia capillaris (A. capillaris) is a common herbal drug used for thousands years in ancient China. A. Read More

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http://dx.doi.org/10.1016/j.kjms.2017.11.005DOI Listing
March 2018
5 Reads

A virus-like particle vaccine protects mice against coxsackievirus A10 lethal infection.

Antiviral Res 2018 04 20;152:124-130. Epub 2018 Feb 20.

Unit of Vaccinology & Antiviral Strategies, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China. Electronic address:

Coxsackievirus A10 (CVA10) has emerged worldwide as one of the main pathogens of hand, foot, and mouth disease (HFMD) in recent years. However, there is currently no commercial vaccine available to prevent CVA10 infection. Here we report the development of a recombinant virus-like particle (VLP) based candidate vaccine for CVA10. Read More

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http://dx.doi.org/10.1016/j.antiviral.2018.02.016DOI Listing
April 2018
4 Reads

Parental perspectives on hand, foot, and mouth disease among children in Hong Kong: a longitudinal study.

Epidemiol Infect 2018 02 1;146(3):324-332. Epub 2018 Feb 1.

Division of Behavioural Sciences,School of Public Health,The University of Hong Kong,Hong Kong,China.

Hand, foot, and mouth disease (HFMD), usually a self-limiting illness for young children, could cause a significant burden for parents because it can take up to 1-2 weeks for a sick child to recover. We conducted a two-wave longitudinal study over one summer peak season (May-July 2014) of HFMD to examine parents' HFMD-related risk perceptions and protective responses. In total, 618 parents with at least one child aged ⩽12 years, recruited using randomly-dialled household telephone calls completed the baseline survey interview, 452 of whom subsequently completed the follow-up survey. Read More

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http://dx.doi.org/10.1017/S0950268818000018DOI Listing
February 2018
38 Reads

Inhibition of EV71 by curcumin in intestinal epithelial cells.

PLoS One 2018 25;13(1):e0191617. Epub 2018 Jan 25.

Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan.

EV71 is a positive-sense single-stranded RNA virus that belongs to the Picornaviridae family. EV71 infection may cause various symptoms ranging from hand-foot-and-mouth disease to neurological pathological conditions such as aseptic meningitis, ataxia, and acute transverse myelitis. There is currently no effective treatment or vaccine available. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191617PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784943PMC
March 2018
2 Reads

Prohibitin plays a critical role in Enterovirus 71 neuropathogenesis.

PLoS Pathog 2018 01 11;14(1):e1006778. Epub 2018 Jan 11.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

A close relative of poliovirus, enterovirus 71 (EV71) is regarded as an important neurotropic virus of serious public health concern. EV71 causes Hand, Foot and Mouth Disease and has been associated with neurological complications in young children. Our limited understanding of the mechanisms involved in its neuropathogenesis has hampered the development of effective therapeutic options. Read More

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http://dx.doi.org/10.1371/journal.ppat.1006778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764453PMC
January 2018
6 Reads

Risk factors for death in children with critical and severe hand-foot-and-mouth disease in Chongqing, China: An observational study.

Medicine (Baltimore) 2017 Dec;96(49):e8934

Infection Department of the Children's Hospital, The Pediatrics Institution of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, The Children's Hospital of Chongqing Medical University, Chongqing, P.R. China.

Hand-foot-and-mouth disease (HFMD) is a common childhood infection that may lead to serious complications and even death. Globally, epidemics of HFMD are increasing each year, especially in China. This study aimed to identify risk factors for death in children with critical and severe HFMD in Chongqing, China. Read More

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http://dx.doi.org/10.1097/MD.0000000000008934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728875PMC
December 2017
61 Reads

Mortality in Children with Severe Hand, Foot and Mouth Disease in Guangxi, China.

Indian Pediatr 2018 02 14;55(2):137-139. Epub 2017 Dec 14.

Departments of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. Correspondence to: Dr Dan Wei, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Objective: To analyze the clinical features of children with hand foot and mouth disease (HFMD) who died.

Methods: 331 deaths due to HFMD between 2010 and 2014 were included in this retrospective study; 15 autopsies were performed.

Results: Most deaths were seen in children aged below 3 y, and with enterovirus 71 infection (91%). Read More

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February 2018
8 Reads

Immunopathogenesis and Virus-Host Interactions of Enterovirus 71 in Patients with Hand, Foot and Mouth Disease.

Front Microbiol 2017 28;8:2249. Epub 2017 Nov 28.

Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.

Enterovirus 71 (EV71) is a global infectious disease that affects millions of people. The virus is the main etiological agent for hand, foot, and mouth disease with outbreaks and epidemics being reported globally. Infection can cause severe neurological, cardiac, and respiratory problems in children under the age of 5. Read More

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http://dx.doi.org/10.3389/fmicb.2017.02249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713468PMC
November 2017
11 Reads

Serum interleukin-6 levels as an indicator of aseptic meningitis among children with enterovirus 71-induced hand, foot and mouth disease.

Postgrad Med 2018 Mar 14;130(2):258-263. Epub 2017 Dec 14.

a Department of Pediatrics , College of Medicine, The Catholic University of Korea , Seoul , Republic of Korea.

Objectives: The enterovirus EV71 is a major pathogen of hand, foot, and mouth disease (HFMD) in children. Aseptic meningitis is the most common neurologic complication of EV71-induced HFMD. Lumbar puncture is a crucial procedure in the diagnosis of aseptic meningitis. Read More

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http://dx.doi.org/10.1080/00325481.2018.1416257DOI Listing
March 2018
14 Reads

Papular Purpuric Gloves and Socks Syndrome because of a Mycoplasma Infection.

J Pediatr 2018 03 6;194:258-258.e2. Epub 2017 Dec 6.

Department of Pediatrics Queen Paola Children's Hospital Antwerp, Belgium; Department of Pediatric Hematology Oncology UZ Brussel Brussels, Belgium.

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http://dx.doi.org/10.1016/j.jpeds.2017.10.050DOI Listing
March 2018
5 Reads

Developing a Machine Learning System for Identification of Severe Hand, Foot, and Mouth Disease from Electronic Medical Record Data.

Sci Rep 2017 Nov 27;7(1):16341. Epub 2017 Nov 27.

Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Children of severe hand, foot, and mouth disease (HFMD) often present with same clinical features as those of mild HFMD during the early stage, yet later deteriorate rapidly with a fulminant disease course. Our goal was to: (1) develop a machine learning system to automatically identify cases with high risk of severe HFMD at the time of admission; (2) compare the effectiveness of the new system with the existing risk scoring system. Data on 2,532 HFMD children admitted between March 2012 and July 2015, were collected retrospectively from a medical center in China. Read More

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http://dx.doi.org/10.1038/s41598-017-16521-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703994PMC
November 2017
9 Reads

MiR-16-5p mediates a positive feedback loop in EV71-induced apoptosis and suppresses virus replication.

Sci Rep 2017 Nov 27;7(1):16422. Epub 2017 Nov 27.

CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.

Enterovirus 71 (EV71) is the predominant causative pathogen of hand-foot-and-mouth disease (HFMD). Contrary to other HFMD-causing enterovirus, EV71 can lead to severe neurological complications, even death. MicroRNAs (miRNAs) are small non-coding RNAs that constitute the largest family of gene regulators participating in numerous biological or pathological processes. Read More

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http://dx.doi.org/10.1038/s41598-017-16616-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703983PMC
November 2017
12 Reads

Interleukin-35 Modulates the Imbalance Between Regulatory T Cells and T Helper 17 Cells in Enterovirus 71-Induced Hand, Foot, and Mouth Disease.

J Interferon Cytokine Res 2017 12 27;37(12):522-530. Epub 2017 Nov 27.

2 Department of Infectious Diseases, The First Affiliated Hospital of Xinxiang Medical University , Weihui, China .

Interleukin (IL)-35 modulates the imbalance between regulatory T cells (Tregs) and T helper (Th) 17 cells, which played vital roles in the pathogenesis of autoimmune and infectious diseases. However, the role of Tregs/Th17 cell imbalance and the regulatory functions of IL-35 have remained largely unknown in enterovirus 71 (EV71)-induced hand, foot, and mouth disease (HFMD). In this study, a total of 47 HFMD patients (30 with mild HFMD and 17 with severe HFMD) and 13 healthy individuals were enrolled. Read More

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http://www.liebertpub.com/doi/10.1089/jir.2017.0080
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http://dx.doi.org/10.1089/jir.2017.0080DOI Listing
December 2017
11 Reads

Acute pancreatitis in hand, foot and mouth disease caused by Coxsackievirus A16: case report.

Korean J Pediatr 2017 Oct 20;60(10):333-336. Epub 2017 Oct 20.

Department of Pediatrics, Hallym University Sacred Heart Hospital, Anyang, Korea.

Coxsackievirus A16 (CA16), which primarily causes hand, foot, and mouth disease (HFMD), is associated with complications, such as encephalitis, acute flaccid paralysis, myocarditis, pericarditis, and shock. However, no case of pancreatitis associated with CA16 has been reported in children. We report a case of CA16-associated acute pancreatitis in a 3-year-old girl with HFMD. Read More

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http://dx.doi.org/10.3345/kjp.2017.60.10.333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687981PMC
October 2017
3 Reads